Pub Date : 2024-09-17DOI: 10.1080/19491034.2024.2398450
Yee Mon Thu
Sumoylation, a process in which SUMO (small ubiquitin like modifier) is conjugated to target proteins, emerges as a post-translational modification that mediates protein−protein interactions, prote...
{"title":"Multifaceted roles of SUMO in DNA metabolism","authors":"Yee Mon Thu","doi":"10.1080/19491034.2024.2398450","DOIUrl":"https://doi.org/10.1080/19491034.2024.2398450","url":null,"abstract":"Sumoylation, a process in which SUMO (small ubiquitin like modifier) is conjugated to target proteins, emerges as a post-translational modification that mediates protein−protein interactions, prote...","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":"47 1","pages":"2398450"},"PeriodicalIF":3.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142261520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-16DOI: 10.1080/19491034.2024.2399247
Atsushi Matsuda,Abdullah Mansour,Mohammad R K Mofrad
The nuclear pore complex (NPC) is a critical gateway regulating molecular transport between the nucleus and cytoplasm. It allows small molecules to pass freely, while larger molecules require nuclear transport receptors to traverse the barrier. This selective permeability is maintained by phenylalanine-glycine-rich nucleoporins (FG-Nups), intrinsically disordered proteins that fill the NPC's central channel. The disordered and flexible nature of FG-Nups complicates their spatial characterization with conventional structural biology techniques. To address this challenge, polymer physics offers a valuable framework for describing FG-Nup behavior, reducing their complex structures to a few key parameters. In this review, we explore how polymer physics models FG-Nups using these parameters and discuss experimental efforts to quantify them in various contexts, providing insights into the conformational properties of FG-Nups.
{"title":"Deciphering the intrinsically disordered characteristics of the FG-Nups through the lens of polymer physics.","authors":"Atsushi Matsuda,Abdullah Mansour,Mohammad R K Mofrad","doi":"10.1080/19491034.2024.2399247","DOIUrl":"https://doi.org/10.1080/19491034.2024.2399247","url":null,"abstract":"The nuclear pore complex (NPC) is a critical gateway regulating molecular transport between the nucleus and cytoplasm. It allows small molecules to pass freely, while larger molecules require nuclear transport receptors to traverse the barrier. This selective permeability is maintained by phenylalanine-glycine-rich nucleoporins (FG-Nups), intrinsically disordered proteins that fill the NPC's central channel. The disordered and flexible nature of FG-Nups complicates their spatial characterization with conventional structural biology techniques. To address this challenge, polymer physics offers a valuable framework for describing FG-Nup behavior, reducing their complex structures to a few key parameters. In this review, we explore how polymer physics models FG-Nups using these parameters and discuss experimental efforts to quantify them in various contexts, providing insights into the conformational properties of FG-Nups.","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":"10 1","pages":"2399247"},"PeriodicalIF":3.7,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142261523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The second FASEB conference on Nuclear Bodies: Hubs of Genome Activity was held June 2-7, 2024, at Niagara Falls, NY. The central theme was how these protein and RNA-protein complexes that are situated in the nucleus outside the genome support and regulate gene expression. Topics included their relevance to disease, especially cancer, their molecular dynamics, and their phase separation transition properties. The meeting included numerous trainees as speakers and session chairs, hosted a memorable Keynote talk on diversity, and a vibrant career development session.
{"title":"Nuclear bodies: concentrating at an aqueous site, with momentum.","authors":"Ling-Ling Chen,Erica Larschan,A Gregory Matera,Amy Strom,Thoru Pederson","doi":"10.1080/19491034.2024.2404677","DOIUrl":"https://doi.org/10.1080/19491034.2024.2404677","url":null,"abstract":"The second FASEB conference on Nuclear Bodies: Hubs of Genome Activity was held June 2-7, 2024, at Niagara Falls, NY. The central theme was how these protein and RNA-protein complexes that are situated in the nucleus outside the genome support and regulate gene expression. Topics included their relevance to disease, especially cancer, their molecular dynamics, and their phase separation transition properties. The meeting included numerous trainees as speakers and session chairs, hosted a memorable Keynote talk on diversity, and a vibrant career development session.","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":"18 1","pages":"2404677"},"PeriodicalIF":3.7,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142261521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-11DOI: 10.1080/19491034.2024.2310452
Erin R. Butterfield, Samson O. Obado, Simon R. Scutts, Wenzhu Zhang, Brian T. Chait, Michael P. Rout, Mark C. Field
The nuclear envelope (NE) separates translation and transcription and is the location of multiple functions, including chromatin organization and nucleocytoplasmic transport. The molecular basis fo...
核膜（NE）将翻译和转录分开，是染色质组织和核细胞质运输等多种功能的所在地。其分子基础是...
{"title":"A lineage-specific protein network at the trypanosome nuclear envelope","authors":"Erin R. Butterfield, Samson O. Obado, Simon R. Scutts, Wenzhu Zhang, Brian T. Chait, Michael P. Rout, Mark C. Field","doi":"10.1080/19491034.2024.2310452","DOIUrl":"https://doi.org/10.1080/19491034.2024.2310452","url":null,"abstract":"The nuclear envelope (NE) separates translation and transcription and is the location of multiple functions, including chromatin organization and nucleocytoplasmic transport. The molecular basis fo...","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":"164 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140589161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-10DOI: 10.1080/19491034.2024.2339214
Isabella E. Perales, Samuel D. Jones, Katherine M. Piaszynski, Pamela K. Geyer
The nuclear lamina (NL) changes composition for regulation of nuclear events. We investigated changes that occur in Drosophila oogenesis, revealing switches in NL composition during germ cell diffe...
{"title":"Developmental changes in nuclear lamina components during germ cell differentiation","authors":"Isabella E. Perales, Samuel D. Jones, Katherine M. Piaszynski, Pamela K. Geyer","doi":"10.1080/19491034.2024.2339214","DOIUrl":"https://doi.org/10.1080/19491034.2024.2339214","url":null,"abstract":"The nuclear lamina (NL) changes composition for regulation of nuclear events. We investigated changes that occur in Drosophila oogenesis, revealing switches in NL composition during germ cell diffe...","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":"51 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140602752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-09DOI: 10.1080/19491034.2024.2339220
Maiko Kitaoka, Yukiko M. Yamashita
Species’ continuity depends on gametogenesis to produce the only cell types that can transmit genetic information across generations. Spermiogenesis, which encompasses post-meiotic, haploid stages ...
{"title":"Running the gauntlet: challenges to genome integrity in spermiogenesis","authors":"Maiko Kitaoka, Yukiko M. Yamashita","doi":"10.1080/19491034.2024.2339220","DOIUrl":"https://doi.org/10.1080/19491034.2024.2339220","url":null,"abstract":"Species’ continuity depends on gametogenesis to produce the only cell types that can transmit genetic information across generations. Spermiogenesis, which encompasses post-meiotic, haploid stages ...","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":"5 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140589581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-21DOI: 10.1080/19491034.2024.2320656
Maria Kristha Fernandez, Molika Sinha, Mia Zidan, Malte Renz
The view on nuclear filaments formed by non-skeletal β-actin has significantly changed over the decades. Initially, filamentous actin was observed in amphibian oocyte nuclei and only under specific...
{"title":"Nuclear actin filaments – a historical perspective","authors":"Maria Kristha Fernandez, Molika Sinha, Mia Zidan, Malte Renz","doi":"10.1080/19491034.2024.2320656","DOIUrl":"https://doi.org/10.1080/19491034.2024.2320656","url":null,"abstract":"The view on nuclear filaments formed by non-skeletal β-actin has significantly changed over the decades. Initially, filamentous actin was observed in amphibian oocyte nuclei and only under specific...","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":"72 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139922420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.1080/19491034.2024.2307665
Martin Rey-Millet, Kerstin Bystricky, the International Nucleome Consortium
DNA sequencing is not enough to grasp the complexity of genome organization and function. The four-dimensional (three in space, one in time) configuration of the eukaryotic nucleus varies with cell...
{"title":"The genome in space and time comes of age","authors":"Martin Rey-Millet, Kerstin Bystricky, the International Nucleome Consortium","doi":"10.1080/19491034.2024.2307665","DOIUrl":"https://doi.org/10.1080/19491034.2024.2307665","url":null,"abstract":"DNA sequencing is not enough to grasp the complexity of genome organization and function. The four-dimensional (three in space, one in time) configuration of the eukaryotic nucleus varies with cell...","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":"37 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139668942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-14DOI: 10.1080/19491034.2023.2293604
Mark S. Geisler, James P. Kemp Jr., Robert J. Duronio
Histone locus bodies (HLBs) are biomolecular condensates that assemble at replication-dependent (RD) histone genes in animal cells. These genes produce unique mRNAs that are not polyadenylated and ...
{"title":"Histone locus bodies: a paradigm for how nuclear biomolecular condensates control cell cycle regulated gene expression","authors":"Mark S. Geisler, James P. Kemp Jr., Robert J. Duronio","doi":"10.1080/19491034.2023.2293604","DOIUrl":"https://doi.org/10.1080/19491034.2023.2293604","url":null,"abstract":"Histone locus bodies (HLBs) are biomolecular condensates that assemble at replication-dependent (RD) histone genes in animal cells. These genes produce unique mRNAs that are not polyadenylated and ...","PeriodicalId":19392,"journal":{"name":"Nucleus","volume":"9 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138629326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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