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Adipose triglyceride lipase gene expression in peripheral blood mononuclear cells of subjects with obesity and its association with insulin resistance, inflammation and lipid accumulation in liver 肥胖患者外周血单核细胞脂肪甘油三酯脂肪酶基因表达及其与胰岛素抵抗、炎症和肝脏脂质积累的关系
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-10-15 DOI: 10.1002/osp4.716
Samira Ezzati‐Mobaser, Sahar Yarahmadi, Nikta Dadkhah Nikroo, Mohammad Hasan Maleki, Zeynab Yousefi, Pegah Golpour, Mona Nourbakhsh, Mitra Nourbakhsh
Abstract Introduction Adipose triglyceride lipase (ATGL) is a crucial enzyme responsible for the release of fatty acids from various tissues. The expression of ATGL is regulated by insulin and this enzyme is linked to insulin resistance. On the other hand, ATGL‐mediated lipolysis is connected to macrophage function and thus ATGL is involved in inflammation and the pathogenesis of lipid‐related disorders. This study aims to investigate the correlation between ATGL, obesity, metabolic syndrome, and inflammation. Methods A total of 100 participants, including 50 individuals with obesity and 50 healthy particiapnts, were recruited for this study and underwent comprehensive clinical evaluations. Blood samples were collected to measure plasma lipid profiles, glycemic indices, and liver function tests. Additionally, peripheral blood mononuclear cells (PBMCs) were isolated and used for the assessment of the gene expression of ATGL, using real‐time PCR. Furthermore, PBMCs were cultured and exposed to lipopolysaccharides (LPS) with simultaneous ATGL inhibition, and the gene expression of inflammatory cytokines, along with the secretion of prostaglandin E2 (PGE2), were measured. Results The gene expression of ATGL was significantly elevated in PBMCs obtained from participants with obesity and was particularly higher in those diagnosed with metabolic syndrome. It exhibited a correlation with insulin levels and Homeostatic Model Assessment for Insulin Resistance (HOMA‐IR), and it was associated with lipid accumulation in the liver. Stimulation with LPS increased ATGL expression in PBMCs, while inhibition of ATGL attenuated the inflammatory responses induced by LPS. Conclusions Obesity and metabolic syndrome were associated with dysregulation of ATGL. ATGL might play a role in the upregulation of inflammatory cytokines and act as a significant contributor to the development of metabolic abnormalities related to obesity. This article is protected by copyright. All rights reserved.
脂肪甘油三酯脂肪酶(ATGL)是一种重要的酶,负责从各种组织中释放脂肪酸。ATGL的表达受胰岛素调控,该酶与胰岛素抵抗有关。另一方面,ATGL介导的脂肪分解与巨噬细胞功能有关,因此ATGL参与炎症和脂质相关疾病的发病机制。本研究旨在探讨ATGL与肥胖、代谢综合征和炎症的相关性。方法共招募100名受试者,包括50名肥胖个体和50名健康受试者,进行综合临床评估。采集血液样本测量血脂、血糖指数和肝功能测试。此外,分离外周血单个核细胞(PBMCs)并使用实时PCR技术评估ATGL基因表达。此外,培养PBMCs并将其暴露于同时抑制ATGL的脂多糖(LPS)中,测量炎症因子的基因表达以及前列腺素E2 (PGE2)的分泌。结果ATGL基因表达在肥胖参与者的pbmc中显著升高,在诊断为代谢综合征的参与者中尤其高。它与胰岛素水平和胰岛素抵抗稳态模型评估(HOMA‐IR)相关,并与肝脏脂质积累有关。LPS刺激增加了pbmc中ATGL的表达,而抑制ATGL则减轻了LPS诱导的炎症反应。结论肥胖和代谢综合征与ATGL异常相关。ATGL可能在炎症细胞因子的上调中发挥作用,并在与肥胖相关的代谢异常的发展中发挥重要作用。这篇文章受版权保护。版权所有。
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引用次数: 0
Lipid Accumulation Product and Visceral Adiposity Index for Incidence of Cardiovascular Diseases and Mortality; Results From 13 Years Follow‐up in Isfahan Cohort Study 脂质积累积和内脏脂肪指数与心血管疾病发病率和死亡率的关系伊斯法罕队列研究13年随访结果
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-10-02 DOI: 10.1002/osp4.713
Mohammad Fakhrolmobasheri, Amir Parsa Abhari, Maryam Heidarpour, Saina Paymannejad, Mahsa Pourmahdi‐Boroujeni, Amir Sepehr Saffari, Paria Okhovat, Hamidreza Roohafza, Masoumeh Sadeghi, Najmeh Rabanipour, Davood Shafie, Nizal Sarrafzadehgan
Abstract Background /Aims: Visceral adiposity index (VAI) and lipid accumulation product (LAP) are novel anthropometric indices that have shown an association with metabolic syndrome; however, limited data are available regarding the predictive performance of these indices for the incidence of cardiovascular diseases (CVD) and mortality. Methods This study was performed on the data retrieved from Isfahan Cohort Study (ICS). ICS is an ongoing population‐based cohort study conducted in 3 counties in central Iran. Pearson correlation analysis was performed between LAP, VAI, and metabolic parameters. Cox regression analysis and receiver operative characteristics (ROC) curve analysis were performed in order to evaluate the ability of VAI and LAP for the incidence of CVD, CVD‐associated mortality, and all‐cause mortality. We further compared the predictive performance of VAI and LAP with body mass index (BMI). Results LAP and VAI were significantly correlated with all metabolic variables, including blood pressure, fasting blood glucose, and lipid profile components. Univariate regression analysis indicated a significant association between LAP and VAI and CVD incidence. In multivariate analysis, only VAI was significantly associated with CVD incidence. Regarding CVD mortality, only VAI in the multivariate analysis revealed a significant association. Interestingly, Both VAI and LAP were negatively associated with all‐cause mortality. ROC curve analysis indicated the superior performance of LAP and VAI for predicting CVD incidence compared to BMI; however, BMI was better in predicting all‐cause mortality. Conclusion Compared to BMI, LAP and VAI have better predictive performance for the incidence of CVD. In contrast, BMI was superior to VAI and LAP in the prediction of all‐cause mortality.
背景/目的:内脏脂肪指数(VAI)和脂质积累产物(LAP)是一种新的人体测量指标,已显示与代谢综合征相关;然而,关于这些指标对心血管疾病(CVD)发病率和死亡率的预测性能的数据有限。方法本研究的数据来源于Isfahan队列研究(ICS)。ICS是一项正在伊朗中部3个县进行的基于人口的队列研究。对LAP、VAI和代谢参数进行Pearson相关分析。为了评估VAI和LAP对CVD发生率、CVD相关死亡率和全因死亡率的影响,我们进行了Cox回归分析和受试者手术特征(ROC)曲线分析。我们进一步比较了VAI和LAP与身体质量指数(BMI)的预测性能。结果LAP和VAI与所有代谢变量,包括血压、空腹血糖和血脂组分均显著相关。单因素回归分析显示LAP和VAI与CVD发病率有显著相关性。在多变量分析中,只有VAI与CVD发病率显著相关。关于CVD死亡率,在多变量分析中只有VAI显示出显著的相关性。有趣的是,VAI和LAP都与全因死亡率呈负相关。ROC曲线分析显示LAP和VAI在预测心血管疾病发病率方面优于BMI;然而,BMI在预测全因死亡率方面效果更好。结论与BMI相比,LAP和VAI对心血管疾病发病率的预测效果更好。相比之下,BMI在预测全因死亡率方面优于VAI和LAP。
{"title":"Lipid Accumulation Product and Visceral Adiposity Index for Incidence of Cardiovascular Diseases and Mortality; Results From 13 Years Follow‐up in Isfahan Cohort Study","authors":"Mohammad Fakhrolmobasheri, Amir Parsa Abhari, Maryam Heidarpour, Saina Paymannejad, Mahsa Pourmahdi‐Boroujeni, Amir Sepehr Saffari, Paria Okhovat, Hamidreza Roohafza, Masoumeh Sadeghi, Najmeh Rabanipour, Davood Shafie, Nizal Sarrafzadehgan","doi":"10.1002/osp4.713","DOIUrl":"https://doi.org/10.1002/osp4.713","url":null,"abstract":"Abstract Background /Aims: Visceral adiposity index (VAI) and lipid accumulation product (LAP) are novel anthropometric indices that have shown an association with metabolic syndrome; however, limited data are available regarding the predictive performance of these indices for the incidence of cardiovascular diseases (CVD) and mortality. Methods This study was performed on the data retrieved from Isfahan Cohort Study (ICS). ICS is an ongoing population‐based cohort study conducted in 3 counties in central Iran. Pearson correlation analysis was performed between LAP, VAI, and metabolic parameters. Cox regression analysis and receiver operative characteristics (ROC) curve analysis were performed in order to evaluate the ability of VAI and LAP for the incidence of CVD, CVD‐associated mortality, and all‐cause mortality. We further compared the predictive performance of VAI and LAP with body mass index (BMI). Results LAP and VAI were significantly correlated with all metabolic variables, including blood pressure, fasting blood glucose, and lipid profile components. Univariate regression analysis indicated a significant association between LAP and VAI and CVD incidence. In multivariate analysis, only VAI was significantly associated with CVD incidence. Regarding CVD mortality, only VAI in the multivariate analysis revealed a significant association. Interestingly, Both VAI and LAP were negatively associated with all‐cause mortality. ROC curve analysis indicated the superior performance of LAP and VAI for predicting CVD incidence compared to BMI; however, BMI was better in predicting all‐cause mortality. Conclusion Compared to BMI, LAP and VAI have better predictive performance for the incidence of CVD. In contrast, BMI was superior to VAI and LAP in the prediction of all‐cause mortality.","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135790227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Home access to a weight scale in the Hispanic/Latino population attending a community‐based free clinic 参加社区免费诊所的西班牙裔/拉丁裔人群的家庭体重秤
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-09-30 DOI: 10.1002/osp4.711
Ken Fujioka, Jacob Fujioka, Kaley Mafong, Nicole Wetherhold, Sally Kim, Amin Rasul, Alyssa Lopez, Kevin Cummins
Abstract Background Daily weighing has been shown to help with weight management. In primary care, the majority of virtual visits will ask patients about their weight. However, little is known about whether patients, especially those in the Hispanic/Latino population, have access to a weight scale. Our aim was to determine scale access and perceived height and weight in the Hispanic/Latino population attending a volunteer, no cost, community clinic. Methods Questionnaires were issued to patients attending the community clinic and a comparator group attending a medically insured primary care practice. Results Only 52% of the Hispanic/Latino patients attending the community clinic had access to a scale compared with 85% of patients in the primary care office. Patients underreported weight and overreported height leading to underreporting body mass index by 0.6 ± 3.2 kg/m 2 . Conclusions Healthcare providers who care for uninsured Hispanic/Latino patients in community clinics may need to be aware that patients may not have access to a scale.
每日称重已被证明有助于体重管理。在初级保健中,大多数虚拟访问将询问患者的体重。然而,对于患者,特别是西班牙裔/拉丁裔人群,是否有机会使用体重秤,我们知之甚少。我们的目的是确定西班牙裔/拉丁裔人群参加志愿者,免费社区诊所的规模访问和感知身高和体重。方法对在社区诊所就诊的患者和在医疗保险初级保健诊所就诊的对照组进行问卷调查。结果在社区诊所就诊的西班牙裔/拉丁裔患者中,仅有52%的患者获得了量表,而在初级保健办公室就诊的患者中,这一比例为85%。患者低报体重,高报身高,导致体重指数低报0.6±3.2 kg/ m2。结论:在社区诊所照顾未参保西班牙裔/拉丁裔患者的医疗保健提供者可能需要意识到患者可能无法获得量表。
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引用次数: 0
Effect of overweight/obesity and metabolic syndrome on frailty in middle‐aged and older Japanese adults 超重/肥胖和代谢综合征对日本中老年成年人虚弱的影响
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-09-27 DOI: 10.1002/osp4.714
Yuki Nishida, Yosuke Yamada, Satoshi Sasaki, Eiichiro Kanda, Yoshihiko Kanno, Tatsuhiko Anzai, Kunihiko Takahashi, Keita Yamauchi, Fuminori Katsukawa
Abstract Background The potential for developing frailty exists in middle‐aged and older adults. While obesity and metabolic syndrome (MetS) increase the risk of frailty in older adults, this relationship remains unclear in middle‐aged adults, who are prone to developing lifestyle‐related diseases. Objective To examine the effect of overweight/obesity and MetS on frailty development in middle‐aged and older Japanese adults using real‐world data. Methods This nationwide cohort study used exhaustive health insurance claims data of 3,958,708 Japanese people from 2015 to 2019 provided by the Japan Health Insurance Association. Participants aged ≥35 and < 70 years who received health checkups in 2015 were included. Multivariate logistic regression was used to assess the effect of body mass index (BMI) and MetS or MetS components (i.e., diabetes, hypertension, and dyslipidemia) in 2015 on frailty risk assessed using the hospital frailty risk score in 2019. Additionally, a subgroup analysis was performed to examine the interaction effects of MetS components and 4‐year weight change (%) on frailty risk among participants who were overweight and obese (BMI ≥25 kg/m 2 ). Results In 2019, 7204 (0.2%) and 253,671 (6.4%) participants were at high and intermediate frailty risks, respectively. Obesity and MetS were independently associated with intermediate/high frailty risk (odds ratio (OR) 1.36, p < 0.05; OR 1.23, p < 0.05, respectively) and high frailty risk (OR 1.80, p < 0.05; OR 1.37, p < 0.05, respectively) in all participants. Although all MetS components were frailty risk factors, these effects diminished with age in both sexes. Subgroup analysis of patients with diabetes revealed that 5%–10% weight loss was associated with reduced frailty risk in both sexes. Conclusions Obesity, MetS, and MetS components were independent frailty risk factors in middle‐aged and older Japanese adults. Weight loss of up to 10% over 4 years prevented frailty in patients with diabetes who were overweight and obese.
背景:中老年人存在发生虚弱的可能性。虽然肥胖和代谢综合征(MetS)会增加老年人的虚弱风险,但这种关系在中年人中仍不清楚,中年人容易患上与生活方式相关的疾病。目的利用真实数据研究超重/肥胖和MetS对日本中老年成年人虚弱发展的影响。方法:本全国性队列研究使用了日本健康保险协会提供的2015年至2019年3,958,708名日本人的健康保险索赔数据。参与者年龄≥35岁;其中包括2015年接受健康检查的70人。采用多变量logistic回归评估2015年体重指数(BMI)和MetS或MetS成分(即糖尿病、高血压和血脂异常)对2019年医院衰弱风险评分评估的衰弱风险的影响。此外,还进行了亚组分析,以检查超重和肥胖(BMI≥25 kg/ m2)的参与者中MetS成分和4年体重变化(%)对衰弱风险的相互作用。结果2019年,7204名(0.2%)和253671名(6.4%)参与者分别处于高度和中度虚弱风险。肥胖和MetS与中/高衰弱风险独立相关(优势比(OR) 1.36, p <0.05;OR 1.23, p <高脆弱风险(OR 1.80, p <0.05;OR 1.37, p <0.05)。尽管所有的代谢代谢成分都是脆弱的危险因素,但这些影响在两性中随着年龄的增长而减弱。糖尿病患者的亚组分析显示,在两性中,体重减轻5%-10%与衰弱风险降低有关。结论:肥胖、MetS和MetS成分是日本中老年成年人的独立衰弱危险因素。超重和肥胖的糖尿病患者在4年内体重减轻10%,可防止身体虚弱。
{"title":"Effect of overweight/obesity and metabolic syndrome on frailty in middle‐aged and older Japanese adults","authors":"Yuki Nishida, Yosuke Yamada, Satoshi Sasaki, Eiichiro Kanda, Yoshihiko Kanno, Tatsuhiko Anzai, Kunihiko Takahashi, Keita Yamauchi, Fuminori Katsukawa","doi":"10.1002/osp4.714","DOIUrl":"https://doi.org/10.1002/osp4.714","url":null,"abstract":"Abstract Background The potential for developing frailty exists in middle‐aged and older adults. While obesity and metabolic syndrome (MetS) increase the risk of frailty in older adults, this relationship remains unclear in middle‐aged adults, who are prone to developing lifestyle‐related diseases. Objective To examine the effect of overweight/obesity and MetS on frailty development in middle‐aged and older Japanese adults using real‐world data. Methods This nationwide cohort study used exhaustive health insurance claims data of 3,958,708 Japanese people from 2015 to 2019 provided by the Japan Health Insurance Association. Participants aged ≥35 and < 70 years who received health checkups in 2015 were included. Multivariate logistic regression was used to assess the effect of body mass index (BMI) and MetS or MetS components (i.e., diabetes, hypertension, and dyslipidemia) in 2015 on frailty risk assessed using the hospital frailty risk score in 2019. Additionally, a subgroup analysis was performed to examine the interaction effects of MetS components and 4‐year weight change (%) on frailty risk among participants who were overweight and obese (BMI ≥25 kg/m 2 ). Results In 2019, 7204 (0.2%) and 253,671 (6.4%) participants were at high and intermediate frailty risks, respectively. Obesity and MetS were independently associated with intermediate/high frailty risk (odds ratio (OR) 1.36, p < 0.05; OR 1.23, p < 0.05, respectively) and high frailty risk (OR 1.80, p < 0.05; OR 1.37, p < 0.05, respectively) in all participants. Although all MetS components were frailty risk factors, these effects diminished with age in both sexes. Subgroup analysis of patients with diabetes revealed that 5%–10% weight loss was associated with reduced frailty risk in both sexes. Conclusions Obesity, MetS, and MetS components were independent frailty risk factors in middle‐aged and older Japanese adults. Weight loss of up to 10% over 4 years prevented frailty in patients with diabetes who were overweight and obese.","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135477021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends in the burden of most common obesity‐related cancers in 16 Southern Africa Development Community countries, 1990‐2019. Findings from the Global Burden of Disease Study 1990 - 2019年南部非洲发展共同体16个国家最常见肥胖相关癌症负担趋势来自全球疾病负担研究的发现
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-09-27 DOI: 10.1002/osp4.715
Philimon Gona, Clara Gona, Suha Ballout, Chabila Mapoma, Sowmya Rao, Ali Mokdad
Abstract Background Obesity‐related cancers in the 16 Southern African Development Community (SADC) countries is quite prominent. The changes and time trends of the burden of obesity‐related cancers in developing countries like SADC remain largely unknown. A descriptive epidemiological analysis was conducted to assess the burden of obesity‐related cancers, (liver, esophageal, breast, prostate, colon/rectal, leukemia, ovarian, uterine, pancreatic, kidney, gallbladder/biliary tract, and thyroid cancers) in SADC countries. Methods Data from the 2019 Global Burden of Diseases (GBD) Study was used. Deaths extracted from vital registration, verbal autopsies and ICD codes. Cancer‐type, mortality and prevalence per 100,000 population and 95% uncertainty intervals (UIs) were calculated using the Cause of Death Ensemble model (CODEm) and Spatio‐Temporal Gaussian process with mixed effects regression models. Annual rates of change (AROCs) between 1990 and 2019 and the corresponding UIs were calculated. Results The top age‐standardized mortality rates per 100,000 in 2019 for males were leukemia, 20.1(14.4‐26.4), esophageal cancer, 15.1 (11.2‐19.1), and colon and rectal cancer, 10.3 (8.6‐12.6). For females, breast cancer, 20.6 (16.6‐25.0), leukemia, 17.1 (11.4‐23.7), and esophageal cancer, 8.3(5.5‐10.7), had the leading mortality rates. For males, AROC substantial (p<0.05) increase for kidney cancer for 11 of the countries (AROC from 0.41‐1.24%), colon cancer for eight of the countries (from 0.39‐0.92%), and pancreatic cancer for seven countries (from 0.26‐1.01%). In females, AROC showed substantial increase for pancreatic cancer for 13 of the countries from (0.34‐1.67%), nine countries for kidney cancer (from 0.27‐1.02%), seven countries each for breast cancer (0.35‐1.13%), and ovarian cancer (from 0.33‐1.21%). Conclusions There is need for location‐specific and culturally appropriate strategies for better nutrition and weight control, and improved screening for all cancers. Health promotion messaging should target kidney, colon, pancreatic, and breast cancers and encourage clinically tested methods of reducing BMI such as increasing personal physical activity and adoption of effective dietary regimes. This article is protected by copyright. All rights reserved.
背景:肥胖相关癌症在南部非洲发展共同体(SADC) 16个国家中相当突出。在南共体等发展中国家,肥胖相关癌症负担的变化和时间趋势在很大程度上仍然未知。对南共体国家肥胖相关癌症(肝癌、食道癌、乳腺癌、前列腺癌、结肠/直肠癌、白血病、卵巢癌、子宫癌、胰腺癌、肾癌、胆囊/胆道癌和甲状腺癌)的负担进行了描述性流行病学分析。方法使用2019年全球疾病负担(GBD)研究的数据。从生命登记、口头尸检和疾病分类代码中提取的死亡人数。使用死亡原因集合模型(CODEm)和时空高斯过程混合效应回归模型计算癌症类型、每10万人的死亡率和患病率以及95%的不确定性区间(ui)。计算了1990年至2019年的年变化率(AROCs)和相应的ui。结果2019年男性年龄标准化死亡率最高的是白血病,20.1(14.4‐26.4),食管癌,15.1(11.2‐19.1),结肠癌和直肠癌,10.3(8.6‐12.6)。女性死亡率最高的是乳腺癌,20.6(16.6‐25.0),白血病,17.1(11.4‐23.7),食管癌,8.3(5.5‐10.7)。对于男性而言,11个国家肾癌的AROC显著(p<0.05)增加(AROC从0.41‐1.24%),8个国家结肠癌(从0.39‐0.92%),7个国家胰腺癌(从0.26‐1.01%)。在女性AROC中,13个国家的胰腺癌发病率从(0.34‐1.67%)大幅增加,9个国家的肾癌发病率从(0.27‐1.02%)大幅增加,7个国家的乳腺癌发病率从(0.35‐1.13%)大幅增加,卵巢癌发病率从(0.33‐1.21%)大幅增加。结论:需要针对特定地区和文化的策略来更好地控制营养和体重,并改进所有癌症的筛查。健康促进信息应针对肾癌、结肠癌、胰腺癌和乳腺癌,并鼓励临床试验的降低BMI的方法,如增加个人体育活动和采用有效的饮食制度。这篇文章受版权保护。版权所有。
{"title":"Trends in the burden of most common obesity‐related cancers in 16 Southern Africa Development Community countries, 1990‐2019. Findings from the Global Burden of Disease Study","authors":"Philimon Gona, Clara Gona, Suha Ballout, Chabila Mapoma, Sowmya Rao, Ali Mokdad","doi":"10.1002/osp4.715","DOIUrl":"https://doi.org/10.1002/osp4.715","url":null,"abstract":"Abstract Background Obesity‐related cancers in the 16 Southern African Development Community (SADC) countries is quite prominent. The changes and time trends of the burden of obesity‐related cancers in developing countries like SADC remain largely unknown. A descriptive epidemiological analysis was conducted to assess the burden of obesity‐related cancers, (liver, esophageal, breast, prostate, colon/rectal, leukemia, ovarian, uterine, pancreatic, kidney, gallbladder/biliary tract, and thyroid cancers) in SADC countries. Methods Data from the 2019 Global Burden of Diseases (GBD) Study was used. Deaths extracted from vital registration, verbal autopsies and ICD codes. Cancer‐type, mortality and prevalence per 100,000 population and 95% uncertainty intervals (UIs) were calculated using the Cause of Death Ensemble model (CODEm) and Spatio‐Temporal Gaussian process with mixed effects regression models. Annual rates of change (AROCs) between 1990 and 2019 and the corresponding UIs were calculated. Results The top age‐standardized mortality rates per 100,000 in 2019 for males were leukemia, 20.1(14.4‐26.4), esophageal cancer, 15.1 (11.2‐19.1), and colon and rectal cancer, 10.3 (8.6‐12.6). For females, breast cancer, 20.6 (16.6‐25.0), leukemia, 17.1 (11.4‐23.7), and esophageal cancer, 8.3(5.5‐10.7), had the leading mortality rates. For males, AROC substantial (p<0.05) increase for kidney cancer for 11 of the countries (AROC from 0.41‐1.24%), colon cancer for eight of the countries (from 0.39‐0.92%), and pancreatic cancer for seven countries (from 0.26‐1.01%). In females, AROC showed substantial increase for pancreatic cancer for 13 of the countries from (0.34‐1.67%), nine countries for kidney cancer (from 0.27‐1.02%), seven countries each for breast cancer (0.35‐1.13%), and ovarian cancer (from 0.33‐1.21%). Conclusions There is need for location‐specific and culturally appropriate strategies for better nutrition and weight control, and improved screening for all cancers. Health promotion messaging should target kidney, colon, pancreatic, and breast cancers and encourage clinically tested methods of reducing BMI such as increasing personal physical activity and adoption of effective dietary regimes. This article is protected by copyright. All rights reserved.","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135536098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real world evidence on the characteristics of regular and intermittent users of a very‐low calorie diet program and associations with measures of program success, health, and quality of life 关于定期和间歇性极低卡路里饮食计划使用者特征的真实世界证据,以及与计划成功、健康和生活质量测量的关联
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-09-20 DOI: 10.1002/osp4.712
Patrice Jones, Michelle Blumfield, Emma Beckett, Skye Marshall, Kylie Abbott, Emily Duve, Flavia Fayet‐Moore
Abstract Background Very low‐calorie diet (VLCD) programs are readily available in Australia. However, there is a lack of real‐world evidence describing the characteristics related to positive outcomes. Aims To examine the demographic, eating, self‐efficacy and program engagement characteristics of VLCD users in Australia, and the associations between user characteristics and program success, weight loss, quality of life (QOL) and health. Method Cross‐sectional data from Australian adults; regular users (n=189: VLCD user ≥4 days/week for >4 weeks) and intermittent users (n=111, VLCD user <4 weeks and/or <4 days/week). Self‐reported data on demographics, VLCD program use, support, eating behaviour, weight‐related QOL, mental health, physical health, self‐efficacy, and physical activity. Descriptive and inferential statistics were performed in R. Results Compared to regular users, intermittent users reported lower percentage weight loss (15.1%±SD 9.8 vs. 9.9%±SD 6.8, relative to starting weight), fewer reported their VLCD program as very successful (44% vs. 35%), higher depressive symptom scores (8.7±SD 2.8 vs. 6.7±SD 5.1), and lower general self‐efficacy (23.9±SD 4.7 vs. 29.4±SD5.7), nutrition self‐efficacy (11.9± SD 2.0 vs. 14.5± SD 3.1) and weight‐related QOL scores (60.9±SD 22.2 vs. 65.0±SD 11.8; p<0.001 for all). In regular users, older age and longer program duration were associated with greater total weight loss, support, and program success (p<0.001 for all). In intermittent users, program success was greater when dietitian support was used (OR 6.50) and for those with higher BMIs (OR 1.08, p<0.001 for all). In both groups, more frequent support was associated with better weight‐related QOL (p<0.001). Conclusion This study provides real‐world evidence that regular VLCD users had greater success and weight loss over intermittent program users. Findings may be used to tailor and improve the delivery of VLCD programs in Australia and other countries with retail access to VLCDs. This article is protected by copyright. All rights reserved.
背景极低热量饮食(VLCD)计划在澳大利亚很容易获得。然而,缺乏真实世界的证据来描述与积极结果相关的特征。目的研究澳大利亚VLCD用户的人口统计学、饮食、自我效能和项目参与特征,以及用户特征与项目成功、体重减轻、生活质量和健康之间的关系。方法:澳大利亚成年人的横断面数据;常规用户(n=189: VLCD用户≥4天/周,持续>4周)和间歇性用户(n=111, VLCD用户<4周和/或<4天/周)人口统计、VLCD程序使用、支持、饮食行为、体重相关生活质量、心理健康、身体健康、自我效能和身体活动的自我报告数据。结果与常规使用者相比,间歇性使用者报告的体重减轻百分比较低(相对于初始体重,15.1%±SD 9.8 vs 9.9%±SD 6.8), VLCD计划非常成功的报告较少(44% vs 35%),抑郁症状评分较高(8.7±SD 2.8 vs 6.7±SD 5.1),一般自我效能较低(23.9±SD 4.7 vs 29.4±SD5.7)。营养自我效能(11.9±SD 2.0 vs. 14.5±SD 3.1)和体重相关生活质量评分(60.9±SD 22.2 vs. 65.0±SD 11.8);P<均为0.001)。在常规用户中,年龄越大和项目持续时间越长,总体减重、支持和项目成功程度越高(p<0.001)。在间歇性使用者中,当使用营养师支持时(OR 6.50)和那些bmi较高的人(OR 1.08, p<0.001),计划的成功更大。在两组中,更频繁的支持与更好的体重相关生活质量相关(p<0.001)。结论:这项研究提供了真实世界的证据,证明定期使用VLCD的人比间歇性使用VLCD的人减肥更成功。研究结果可用于定制和改进澳大利亚和其他零售访问VLCD的国家的VLCD计划的交付。这篇文章受版权保护。版权所有。
{"title":"Real world evidence on the characteristics of regular and intermittent users of a very‐low calorie diet program and associations with measures of program success, health, and quality of life","authors":"Patrice Jones, Michelle Blumfield, Emma Beckett, Skye Marshall, Kylie Abbott, Emily Duve, Flavia Fayet‐Moore","doi":"10.1002/osp4.712","DOIUrl":"https://doi.org/10.1002/osp4.712","url":null,"abstract":"Abstract Background Very low‐calorie diet (VLCD) programs are readily available in Australia. However, there is a lack of real‐world evidence describing the characteristics related to positive outcomes. Aims To examine the demographic, eating, self‐efficacy and program engagement characteristics of VLCD users in Australia, and the associations between user characteristics and program success, weight loss, quality of life (QOL) and health. Method Cross‐sectional data from Australian adults; regular users (n=189: VLCD user ≥4 days/week for >4 weeks) and intermittent users (n=111, VLCD user <4 weeks and/or <4 days/week). Self‐reported data on demographics, VLCD program use, support, eating behaviour, weight‐related QOL, mental health, physical health, self‐efficacy, and physical activity. Descriptive and inferential statistics were performed in R. Results Compared to regular users, intermittent users reported lower percentage weight loss (15.1%±SD 9.8 vs. 9.9%±SD 6.8, relative to starting weight), fewer reported their VLCD program as very successful (44% vs. 35%), higher depressive symptom scores (8.7±SD 2.8 vs. 6.7±SD 5.1), and lower general self‐efficacy (23.9±SD 4.7 vs. 29.4±SD5.7), nutrition self‐efficacy (11.9± SD 2.0 vs. 14.5± SD 3.1) and weight‐related QOL scores (60.9±SD 22.2 vs. 65.0±SD 11.8; p<0.001 for all). In regular users, older age and longer program duration were associated with greater total weight loss, support, and program success (p<0.001 for all). In intermittent users, program success was greater when dietitian support was used (OR 6.50) and for those with higher BMIs (OR 1.08, p<0.001 for all). In both groups, more frequent support was associated with better weight‐related QOL (p<0.001). Conclusion This study provides real‐world evidence that regular VLCD users had greater success and weight loss over intermittent program users. Findings may be used to tailor and improve the delivery of VLCD programs in Australia and other countries with retail access to VLCDs. This article is protected by copyright. All rights reserved.","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136374480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Higher BMI is Strongly Linked to Poor Outcomes in Adult COVID‐19 Hospitalizations: A National Inpatient Sample Study 高BMI与成人COVID - 19住院治疗的不良结果密切相关:一项全国住院患者样本研究
Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-09-11 DOI: 10.1002/osp4.692
Ahmed Elkhapery, Ali Abdelhay, Hemanth Krishna Boppana, Zeinab Abdalla, Mohamed Mohamed, Omar Al‐Ali, Anas Hashem, Amir Mahmoud, Eisa Mahmoud, Chengu Niu, Rami Dalbah, Ming‐Yan Chow
Abstract Aims The coronavirus disease 2019 (COVID‐19) pandemic has resulted in more than 6 million deaths worldwide. Studies on the impact of obesity on patients hospitalized with COVID‐19 pneumonia have been conflicting, with some studies describing worse outcomes in patients with obesity, while other studies reporting no difference in outcomes. Previous studies on obesity and critical illness have described improved outcomes in patients with obesity, termed the “obesity paradox.” The study assessed the impact of obesity on the outcomes of COVID‐19 hospitalizations, using a nationally representative database. Materials and Methods ICD‐10 code U071 was used to identify all hospitalizations with the principal diagnosis of COVID‐19 infection in the National Inpatient Database 2020. ICD‐10 codes were used to identify outcomes and comorbidities. Hospitalizations were grouped based on body mass index (BMI). Multivariable logistic regression was used to adjust for demographic characteristics and comorbidities. Results A total of 56,033 hospitalizations were identified. 48% were male, 49% were white and 22% were black. Patients hospitalized with COVID‐19 pneumonia in the setting of obesity and clinically severe obesity were often younger. Adjusted for differences in comorbidities, there was a significant increase in mortality, incidence of mechanical ventilation, shock, and sepsis with increased BMI. The mortality was highest among hospitalizations with BMI ≥60, with an adjusted odds ratio of 2.66 (95% Confidence interval 2.18–3.24) compared to hospitalizations with normal BMI. There were increased odds of mechanical ventilation across all BMI groups above normal, with the odds of mechanical ventilation increasing with increasing BMI. Conclusion The results show that obesity is independently associated with worse patient outcomes in COVID‐19 hospitalizations and is associated with higher in‐patient mortality and higher rates of mechanical ventilation. The underlying mechanism of this is unclear, and further studies are needed to investigate the cause of this.
2019冠状病毒病(COVID - 19)大流行已导致全球600多万人死亡。关于肥胖对COVID - 19肺炎住院患者影响的研究一直存在矛盾,一些研究描述肥胖患者的预后较差,而另一些研究报告结果没有差异。先前关于肥胖和危重疾病的研究描述了肥胖患者的改善结果,称为“肥胖悖论”。该研究使用具有全国代表性的数据库评估了肥胖对COVID - 19住院治疗结果的影响。材料和方法使用ICD‐10代码U071对国家住院患者数据库2020中主要诊断为COVID‐19感染的所有住院患者进行识别。使用ICD‐10代码来确定结果和合并症。根据身体质量指数(BMI)对住院情况进行分组。使用多变量逻辑回归来调整人口统计学特征和合并症。结果共发现56033例住院病例。其中48%为男性,49%为白人,22%为黑人。在肥胖和临床重度肥胖的情况下,因COVID - 19肺炎住院的患者往往更年轻。根据合并症的差异进行调整后,随着BMI的增加,死亡率、机械通气、休克和败血症的发生率显著增加。BMI≥60的住院患者死亡率最高,与BMI正常的住院患者相比,校正优势比为2.66(95%可信区间2.18-3.24)。在所有BMI组中,机械通气的几率都高于正常水平,并且机械通气的几率随着BMI的增加而增加。结论肥胖与COVID - 19住院患者预后较差独立相关,并与较高的患者死亡率和机械通气率相关。其潜在的机制尚不清楚,需要进一步的研究来调查其原因。
{"title":"Higher BMI is Strongly Linked to Poor Outcomes in Adult COVID‐19 Hospitalizations: A National Inpatient Sample Study","authors":"Ahmed Elkhapery, Ali Abdelhay, Hemanth Krishna Boppana, Zeinab Abdalla, Mohamed Mohamed, Omar Al‐Ali, Anas Hashem, Amir Mahmoud, Eisa Mahmoud, Chengu Niu, Rami Dalbah, Ming‐Yan Chow","doi":"10.1002/osp4.692","DOIUrl":"https://doi.org/10.1002/osp4.692","url":null,"abstract":"Abstract Aims The coronavirus disease 2019 (COVID‐19) pandemic has resulted in more than 6 million deaths worldwide. Studies on the impact of obesity on patients hospitalized with COVID‐19 pneumonia have been conflicting, with some studies describing worse outcomes in patients with obesity, while other studies reporting no difference in outcomes. Previous studies on obesity and critical illness have described improved outcomes in patients with obesity, termed the “obesity paradox.” The study assessed the impact of obesity on the outcomes of COVID‐19 hospitalizations, using a nationally representative database. Materials and Methods ICD‐10 code U071 was used to identify all hospitalizations with the principal diagnosis of COVID‐19 infection in the National Inpatient Database 2020. ICD‐10 codes were used to identify outcomes and comorbidities. Hospitalizations were grouped based on body mass index (BMI). Multivariable logistic regression was used to adjust for demographic characteristics and comorbidities. Results A total of 56,033 hospitalizations were identified. 48% were male, 49% were white and 22% were black. Patients hospitalized with COVID‐19 pneumonia in the setting of obesity and clinically severe obesity were often younger. Adjusted for differences in comorbidities, there was a significant increase in mortality, incidence of mechanical ventilation, shock, and sepsis with increased BMI. The mortality was highest among hospitalizations with BMI ≥60, with an adjusted odds ratio of 2.66 (95% Confidence interval 2.18–3.24) compared to hospitalizations with normal BMI. There were increased odds of mechanical ventilation across all BMI groups above normal, with the odds of mechanical ventilation increasing with increasing BMI. Conclusion The results show that obesity is independently associated with worse patient outcomes in COVID‐19 hospitalizations and is associated with higher in‐patient mortality and higher rates of mechanical ventilation. The underlying mechanism of this is unclear, and further studies are needed to investigate the cause of this.","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135938176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to "Maternal vitamin D status in relation to infant BMI growth trajectories up to 2 years of age in two prospective pregnancy cohorts". 修正了“在两个预期怀孕队列中,母亲维生素D状态与婴儿2岁前BMI增长轨迹的关系”。
IF 2.2 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-08-01 DOI: 10.1002/osp4.664

[This corrects the article DOI: 10.1002/osp4.602.].

[更正文章DOI: 10.1002/osp4.602.]。
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引用次数: 0
An intervention to decrease sedentary behavior in older adults: A secondary analysis of a randomized controlled trial. 减少老年人久坐行为的干预措施:一项随机对照试验的二次分析。
IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-06-15 eCollection Date: 2023-10-01 DOI: 10.1002/osp4.687
Nikita Abraham, Kate Lyden, Robert Boucher, Guo Wei, Victoria Gonce, Judy Carle, Katalin Fornadi, Mark A Supiano, Jesse Christensen, Srinivasan Beddhu

Background: Sedentary behaviors are associated with adverse health outcomes in older adults. The feasibility of behavioral interventions in this population is unclear.

Methods: In the Sit Less, Interact, Move More (SLIMM) trial of 106 participants who had obesity, those randomized to the SLIMM intervention (N = 54) were instructed to replace sedentary activities with stepping. An accelerometer was used to measure physical activity. In this secondary analysis, mixed effect models were used to examine the effects of the SLIMM intervention on sedentary and stepping durations and steps/day by age (<70 and ≥ 70 years).

Results: Mean ages in the <70 years (N = 47) and ≥70 years (N = 59) groups were 58 ± 11 and 78 ± 5. In the older subgroup, compared to standard-of-care (N = 29), the SLIMM intervention (N = 30) significantly increased stepping duration (13, 95%CI 1-24 min/d, p = 0.038) and steps per day (1330, 95% CI 322-2338, p = 0.01) and non-significantly decreased sedentary duration by (28,95% CI -61-5 min/d, p = 0.09). In the age <70 subgroup, there was no separation between the standard of care (N = 23) and SLIMM (N = 24) groups.

Discussion: In older adults who had obesity, SLIMM intervention significantly increased stepping duration and steps per day. Interventions targeting sedentary behaviors by promoting low intensity physical activity may be feasible in this population.

背景:久坐行为与老年人的不良健康后果有关。行为干预在这一人群中的可行性尚不清楚。方法:在对106名肥胖参与者进行的“少坐、多互动、多运动”(SLIMM)试验中,随机接受SLIMM干预的参与者(N=54)被指示用踏步代替久坐活动。加速度计被用来测量身体活动。在这项二次分析中,使用混合效应模型来检验SLIMM干预对久坐和步行持续时间以及按年龄划分的步数/天的影响(结果:N=47)和≥70岁(N=59)组的平均年龄分别为58±11和78±5。在老年亚组中,与标准护理(N=29)相比,SLIMM干预(N=30)显著增加了步进持续时间(13,95%CI 1-24 min/d,p=0.038)和每日步数(1330,95%CI 322-2338,p=0.01),而久坐持续时间(28,95%CI-61-5 min/d,p=0.09)无显著减少。在年龄N=23)和SLIMM(N=24)组中。讨论:在患有肥胖症的老年人中,SLIMM干预显著增加了步行时间和每天的步数。通过促进低强度体育活动来针对久坐行为的干预措施在这一人群中可能是可行的。
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引用次数: 0
Geographic differences in the magnitude of black-white disparities in having obesity. 黑人和白人肥胖程度差异的地理差异。
IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-05-26 eCollection Date: 2023-10-01 DOI: 10.1002/osp4.679
Steven A Cohen, Monique J Brown, Furong Xu, Caitlin C Nash, Mary L Greaney

Background: Obesity disparities in the United States are well documented, but the limited body of research suggests that geographic factors may alter the magnitude of these disparities. A growing body of evidence has identified a "rural mortality penalty" where morbidity and mortality rates are higher in rural than urban areas, even after controlling for other factors. Black-White differences in health and mortality are more pronounced in rural areas than in urban areas.

Objective: Therefore, the purpose of this study was to explore how rural-urban status and region moderate Black-White health disparities in obesity.

Methods: Data were abstracted from the 2012 Behavioral Risk Factor Surveillance System, with the sample being restricted to Black and White respondents (n = 403,231). Respondents' county of residence was linked to US Census information to obtain the county-level Index of Relative Rurality (IRR) and Census division. Crude and adjusted logistic regression models were utilized to assess the magnitude of Black-White disparities in having obesity (yes/no) by IRR quartile and by Census division.

Results: Overall, Black-White differences in obesity were wider in rural than in urban counties, with a significant linear trend (p < 0.001). Furthermore, when stratified by US Census division, results revealed that disparities were significantly wider in rural than urban areas for respondents living in the Middle Atlantic and South Atlantic divisions. In contrast, the association was reversed for the remaining divisions (New England, East North Central, West North Central, Mountain, and Pacific), where the magnitude of the Black-White difference was the largest in urban areas.

Conclusion: Findings highlight the need to understand and account for critical place-based factors that exacerbate racial obesity disparities to develop and maximize the effectiveness of policies and programs designed to reduce racial inequalities and improve population health.

背景:美国的肥胖差异有充分的记录,但有限的研究表明,地理因素可能会改变这些差异的程度。越来越多的证据表明,即使在控制了其他因素后,农村地区的发病率和死亡率也高于城市地区的“农村死亡率”。黑人和白人在健康和死亡率方面的差异在农村地区比在城市地区更为明显。目的:因此,本研究的目的是探讨城乡地位和地区如何调节黑人和白人在肥胖方面的健康差异。方法:数据取自2012年行为风险因素监测系统,样本仅限于黑人和白人受访者(n=403231)。受访者的居住县与美国人口普查信息相关联,以获得相对道德县级指数(IRR)和人口普查划分。使用粗略和调整后的逻辑回归模型,通过IRR四分位数和人口普查划分来评估黑人和白人在肥胖方面的差异程度(是/否)。结果:总体而言,黑人和白人在农村地区的肥胖差异比城市县更大,具有显著的线性趋势(p<0.001)。此外,根据美国人口普查部门进行分层时,结果显示,对于生活在中大西洋和南大西洋地区的受访者来说,农村地区的差异比城市地区大得多。相比之下,其余分区(新英格兰、中北部东部、中北部西部、山区和太平洋)的关联性发生了逆转,这些分区的黑白差异在城市地区最大。结论:研究结果强调,需要了解和解释加剧种族肥胖差距的关键地方因素,以制定和最大限度地提高旨在减少种族不平等和改善人口健康的政策和计划的有效性。
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引用次数: 0
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Obesity Science & Practice
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