Nutrition最新文献

{"title":"Re. Mazza et al. “Portable bioimpedance analyzer for remote body composition monitoring: A clinical investigation under controlled conditions”","authors":"Emanuele Cereda M.D., Ph.D. , Riccardo Caccialanza M.D. , Analiza M. Silva Ph.D.","doi":"10.1016/j.nut.2024.112657","DOIUrl":"10.1016/j.nut.2024.112657","url":null,"abstract":"","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"131 ","pages":"Article 112657"},"PeriodicalIF":3.2,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarc-Global: a new sarcopenia screening tool in older adults","authors":"Natalia Correia Lopes MS ,&nbsp;Ana Carolina Costa Vicedomini MS ,&nbsp;Natália Vieira Magalhães MS ,&nbsp;Dan Linetzky Waitzberg MD, PhD ,&nbsp;Wilson Jacob MD ,&nbsp;Alexandre Busse MD ,&nbsp;Douglas Ferdinando MS ,&nbsp;Rosa Maria Rodrigues Pereira MD ,&nbsp;Raquel Torrinhas MD ,&nbsp;Giliane Belarmino MD","doi":"10.1016/j.nut.2024.112654","DOIUrl":"10.1016/j.nut.2024.112654","url":null,"abstract":"<div><h3>Background</h3><div>Sarcopenia is associated with clinical complications that increase mortality in older adults. Current screening tools, such as Sarc-F and Sarc-CalF, focus primarily on muscular performance but have limited sensitivity in identifying elderly individuals at risk of sarcopenia. The present study aims to develop a more comprehensive sarcopenia risk screening tool, Sarc-Global, which integrates additional anthropometric and clinical variables to enhance the sensitivity and accuracy of sarcopenia risk assessment in older adults.</div></div><div><h3>Methods</h3><div>The aim of this cross-sectional study was to develop a sarcopenia risk screening tool, named Sarc-Global, with enhanced sensitivity, incorporating factors pertinent to the overall health of elderly individuals. Utilizing the criteria established by EWGSOP2 for diagnosing sarcopenia, we evaluated 395 community-dwelling elderly individuals. This evaluation served as a reference for assessing the efficacy of two validated questionnaires, Sarc-F and Sarc-CalF, and our newly developed Sarc-Global.</div></div><div><h3>Results</h3><div>Multiple logistic regression revealed that Sarc-Global integrates variables such as sex, age, medication use, body mass index, arm circumference, and handgrip strength, which are significantly associated with sarcopenia (<em>p</em>&lt;0.001). When combined with Sarc-CalF, these variables form the basis of the Sarc-Global model. In screening for sarcopenia risk, Sarc-Global demonstrated superior accuracy, specificity, and sensitivity (74%), outperforming Sarc-F (21%) and Sarc-CalF (34%).</div></div><div><h3>Conclusion</h3><div>Sarc-Global proves to be an effective tool for identifying elderly individuals at risk of sarcopenia.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"131 ","pages":"Article 112654"},"PeriodicalIF":3.2,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of feeding the medium-chain triacylglycerol on GLP-1 secretion in aged Brd4-heterozygous mice, which are a mouse model of aging","authors":"Musashi Kawamura M.S. ,&nbsp;Natsuyo Hariya Ph.D. ,&nbsp;Shiori Ishiyama Ph.D. ,&nbsp;Yuji Tanaka Ph.D. ,&nbsp;Keiko Ozato Ph.D. ,&nbsp;Kazuki Mochizuki Ph.D.","doi":"10.1016/j.nut.2024.112656","DOIUrl":"10.1016/j.nut.2024.112656","url":null,"abstract":"<div><h3>Objectives</h3><div>Gastrointestinal hormones, such as glucagon-like peptide 1 (GLP-1), gastric inhibitory polypeptide, and peptide YY (PYY) are important for reducing malnutrition at older ages because they are related to assimilation and feeding behavior. Medium-chain triacylglycerol (MCT) ameliorates metabolic symptoms and frailty in adults; however, whether it has the same effect in old age is unknown. To address this, we examined the changes in insulin and gastrointestinal hormones in aged <em>Brd4</em> (+/–) mice exhibiting symptoms of old age.</div></div><div><h3>Research Methods and Procedures</h3><div>Aged male wild-type and <em>Brd4</em> (+/–) mice were fed a long-chain triacylglycerol (LCT)- or MCT diet. Feeding, blood glucose, and plasma active GLP-1 protein concentrations were determined at 9 weeks using a meal tolerance test, and those gastrointestinal hormone genes were determined at 10 weeks.</div></div><div><h3>Results</h3><div>The liver and stomach weights and mRNA expression of <em>Gcg</em> (encodes GLP-1 protein) and <em>Pyy</em> in the colon were lower in LCT-fed <em>Brd4</em> (+/–) mice than those in LCT-fed wild-type mice; these were restored by the MCT diet. The blood concentration of active GLP-1 protein at 15 and 30 minutes postload was higher in MCT-fed <em>Brd4</em> (+/–) mice than that in those fed an LCT diet.</div></div><div><h3>Conclusions</h3><div>Aged <em>Brd4</em> (+/–) mice showed lower mRNA expression of <em>Gcg</em> and <em>Pyy</em> genes, and active GLP-1 protein secretion in the blood, which were as restored and enhanced with MCT feeding.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"131 ","pages":"Article 112656"},"PeriodicalIF":3.2,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food protein–induced enterocolitis syndrome after involuntary gluten transgression in celiac children: A new increasingly common complication?","authors":"Carlos Trillo Belizón,&nbsp;Claudia García Barrionuevo,&nbsp;Adrián Muñoz-Cruzado Rosete,&nbsp;Alicia Ramos Rodríguez,&nbsp;Gema Lozano Sánchez,&nbsp;Jose Manuel Ramón Salguero","doi":"10.1016/j.nut.2024.112642","DOIUrl":"10.1016/j.nut.2024.112642","url":null,"abstract":"<div><div>Among the possible adverse reactions to gluten, celiac disease, non-celiac gluten sensitivity, and IgE-mediated wheat allergy have been classically described. A non–IgE-mediated reaction similar to food protein–induced enterocolitis syndrome (FPIES) after inadvertent gluten ingestion in a celiac patient was recently reported. We present three children affected by celiac disease with exquisite control, including appropriate adherence to an exclusion diet, who suffered a severe adverse food reaction after unappreciated outdoor ingestion of gluten, meeting the criteria for a definitive diagnosis of FPIES. The strict and prolonged exclusion of gluten from the diet is postulated as the possible trigger for this serious entity after an involuntary transgression. Although the first published cases are recent, we might be witnessing an increase in the frequency of presentation. Therefore, we believe emergency services must be alert to the possibility of diagnosis of FPIES in celiac patients due to involuntary transgressions. The determination of gluten glycoimmunopeptides in urine or stool samples may be useful for certifying the inadvertent consumption of wheat as the cause of FPIES.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"131 ","pages":"Article 112642"},"PeriodicalIF":3.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of ultra-processed foods on excess weight and dyslipidemia in schoolchildren","authors":"Cynthia Gonçalves Silva M.Sc. Human Nut. ,&nbsp;Claudia Saunders Ph.D. Public Health ,&nbsp;Luiz Felipe da Cruz Rangel Ph.D.Nut.Sci. (Researcher) ,&nbsp;Alessandra Alegre de Matos M.Sc. Human Nut. ,&nbsp;Francisco Martins Teixeira Ph.D. Immunology ,&nbsp;Beatriz Gonçalves Ribeiro Ph.D. Appl. Human Nut.","doi":"10.1016/j.nut.2024.112638","DOIUrl":"10.1016/j.nut.2024.112638","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the impact of the association between the consumption of ultra-processed foods (UPF), excess weight, and dyslipidemia in schoolchildren.</div></div><div><h3>Methods</h3><div>This is a cross-sectional study in which 420 schoolchildren aged 6 to 10 years from public schools in the municipality of Rio das Ostras, Brazil, were evaluated. Food consumption was assessed using the Previous Day Food Questionnaire (PDFQ-3), and physical activity (PA) was assessed using the Previous Day Physical Activity and Food Questionnaire (PDPAFQ). The following parameters were also evaluated: body weight, height, body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR); serum concentrations of triglycerides (TG), total cholesterol (TC), LDL-cholesterol (LDL-c), HDL-cholesterol (HDL-c), and non-HDL-cholesterol. All foods and UPF groups were categorized according to the NOVA classification, and UPF consumption was expressed as a score and classified into tertiles. For statistical analysis, binary logistic regression models were tested and crude and adjusted Odds Ratios (OR) for PA were estimated with 95% confidence intervals (CI).</div></div><div><h3>Results</h3><div>Among the schoolchildren, 98.2% reported consuming UPFs the previous day. The schoolchildren in the “high consumption” tertile evidenced a higher intake of sugary beverages (SB), bread and savory crackers, and french fries. French fries consumption was higher among schoolchildren in the “high consumption” group compared to those in the lower tertiles (<em>p</em>&lt;0.001). The bread and savory crackers group and yogurt were more consumed by those in the “moderate and high consumption” tertiles compared to the “low consumption” tertile (<em>p</em>&lt;0.001). Schoolchildren in the high consumption tertile were more active (43.75% vs. 20.14%) (<em>p</em>&lt;0.001), while those in the low consumption tertile were less active (44.72% vs. 21.14%) (<em>p</em>&lt;0.001). A high prevalence of dyslipidemia (82.96%), excess weight (30.08%), abdominal obesity (AO) (18.3%), and no direct association between UPF consumption and excess weight and dyslipidemia were observed even after adjustment for PA (<em>p</em>&gt;0.05).</div></div><div><h3>Conclusions</h3><div>Despite the high prevalence of dyslipidemia, excess weight, and abdominal obesity observed, no direct association between UPF consumption and these conditions was identified. The practical implications of this study highlight the relevance of public policies and educational strategies aimed at promoting healthier eating habits and encouraging the practice of physical activities among school-age children.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"131 ","pages":"Article 112638"},"PeriodicalIF":3.2,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of adding heparin to parenteral nutrition on catheter intraluminal obstruction based on scanning electron microscopy in preterm neonates: A non-inferiority, randomized controlled trial","authors":"Jiao Li M.D. ,&nbsp;Jing Shi M.D. ,&nbsp;Jing Zhao M.D. ,&nbsp;Tingting Zhu M.D. ,&nbsp;Haiting Liu M.D. ,&nbsp;Xueshi Sun B.S. ,&nbsp;Linan Zeng Ph.D. ,&nbsp;Xiaoyan Yang M.D. ,&nbsp;Hongju Chen M.D. ,&nbsp;Junjie Ying Ph.D. ,&nbsp;Li Zhang M.D. ,&nbsp;Tao Xiong M.D. ,&nbsp;Jun Tang M.D. ,&nbsp;Dezhi Mu M.D.","doi":"10.1016/j.nut.2024.112655","DOIUrl":"10.1016/j.nut.2024.112655","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to assess the need for adding heparin to parenteral nutrition (PN) on reducing catheter intraluminal obstruction based on scanning electron microscopy (SEM) of peripherally inserted central catheter (PICC) in preterm neonates.</div></div><div><h3>Methods</h3><div>In this randomized controlled blinded non-inferiority trial, neonates with gestational age &lt;32 weeks requiring PICC to receive PN were enrolled and randomly divided into two groups. In the heparin group, 0.5 IU/mL heparin was added to PN for continuous infusion through PICC; while in the no-heparin group, there was no heparin added. All catheter tips were collected for SEM of catheter intraluminal obstruction. The primary outcome was the ratio of intraluminal obstructed area at catheter tip calculated by SEM. A non-inferiority margin of 0.1 was chosen. The duration of catheter patency, incidence of catheter-related complications, and heparin-related side effects were analyzed.</div></div><div><h3>Results</h3><div>Between June 1, 2021, and May 31, 2022, 91 neonates (gestational age of 28.17 ± 1.77 weeks) were ultimately enrolled. In the intention-to-treat analysis, the average ratio of intraluminal obstructed area at catheter tip indicated by SEM in no-heparin group was 0.313, and 0.362 in the heparin group (95% confidence intervals of the differences was –0.028 to 0.147). The lower bound of the one-side 95% confidence intervals was greater than –0.1, indicating non-inferiority. No statistically significant differences existed in the duration of catheter patency, the incidence of catheter-related complications between two groups.</div></div><div><h3>Conclusions</h3><div>PN without heparin was non-inferior to the addition of 0.5 IU/mL heparin to PN during infusion on reducing catheter intraluminal obstruction based on SEM of PICC in preterm neonates. These findings could reduce the unnecessary exposure to heparin in preterm neonates.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"131 ","pages":"Article 112655"},"PeriodicalIF":3.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between nutrient intake and inflammatory bowel disease risk: Insights from NHANES data and dose-response analysis","authors":"Nuoya Xiong M.M. ,&nbsp;Wei Zhang Ph.D. ,&nbsp;Yajie Zhang M.M. ,&nbsp;Chunlai Nie Ph.D. ,&nbsp;Hongxia Dan D.M.D.","doi":"10.1016/j.nut.2024.112632","DOIUrl":"10.1016/j.nut.2024.112632","url":null,"abstract":"<div><h3>Background</h3><div>The role of dietary and nutritional factors in inflammatory bowel disease (IBD) remains poorly understood, necessitating further investigation. This study aims to explore the association between nutrient intake and the risk of IBD.</div></div><div><h3>Methods</h3><div>This cross-sectional study utilized data from the 2009–2010 NHANES cycle, focusing on individuals with complete 24-hour dietary intake records and clinically assessed IBD information. Nutrient intake was assessed through dietary recalls and supplement data. Associations between nutrient intake and IBD risk were analyzed by propensity score matching (PSM) with balanced baseline characteristics and logistic regression. Dose-response relationships were examined by restricted cubic splines (RCS). Statistical significance was set at <em>P</em> &lt; 0.05, and analyses were conducted using R software.</div></div><div><h3>Results</h3><div>The study included 4,072 participants with clinically assessed IBD and complete nutrient intake data. In adjusted analyses, lower intake of vitamin B3, copper, phosphorus, selenium, sodium, and protein below the recommended dietary allowance may increase the risk of developing IBD. Similarly, reduced intake of vitamin B6, vitamin E, and total PUFA is associated with elevated susceptibility to IBD.</div></div><div><h3>Conclusion</h3><div>This study elucidates the intricate relationship between nutrient intake and the onset of IBD, underscoring the importance of maintaining a balanced diet for gastrointestinal health. These findings emphasize the significance of informed dietary choices in promoting intestinal wellness and potentially reducing the risk of IBD development.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"131 ","pages":"Article 112632"},"PeriodicalIF":3.2,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tri-Ponderal Mass Index—A reliable anthropometric index for early screening of adolescent obesity in a school-based setting: A cross-sectional study","authors":"Anugya Bharti Ph.D. ,&nbsp;Archana Kushwaha Ph.D. ,&nbsp;Surabhi Singh Yadav M.Sc.","doi":"10.1016/j.nut.2024.112639","DOIUrl":"10.1016/j.nut.2024.112639","url":null,"abstract":"<div><h3>Objective</h3><div>This study was designed to examine the reliability of the Tri-Ponderal Mass Index (TMI) for early screening of adolescent obesity compared with anthropometric measures such as hip circumference, neck circumference, waist circumference, waist-height ratio, waist-hip ratio, and body mass index.</div></div><div><h3>Methods</h3><div>A school-based, cross-sectional study was conducted between July and December 2019 among 1101 school-going adolescents (both sexes) aged 12 to 17 years, in Rudrapur, Uttarakhand, India. Anthropometric measurements were collected using well-calibrated equipment, and age- and sex-specific BMI percentile cutoff values recommended by the Indian Academy of Pediatrics were used to define overweight and obesity. Statistical analysis was done using SPSS software version 16.0. Receiver operating characteristic curve analysis was conducted, and optimal cutoff values for anthropometric measurements were determined using the Youden Index (sensitivity + specificity – 1).</div></div><div><h3>Results</h3><div>Of 1101 study participants, 71.5% (n = 787) and 28.5% (n = 314) were males and females, respectively. The prevalences of overweight and obesity were 10.4% and 4.1%, respectively. Receiver operating characteristic curve analysis was conducted and TMI exhibited the highest Youden Index both in terms of overweight (0.835) and obesity (0.869) among adolescents. The optimal TMI cutoff values for overweight and obese males and females were &gt;12 kg/m³ and &gt;14 kg/m³ and &gt;13 kg/m³ and &gt;16 kg/m³, respectively. The TMI demonstrated superior predictive capacity for early screening of adolescent obesity, as indicated by high discriminative power, sensitivity, and specificity.</div></div><div><h3>Conclusions</h3><div>The TMI can be used as a simple, reliable tool for early screening of overweight and obesity among adolescents.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"131 ","pages":"Article 112639"},"PeriodicalIF":3.2,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dark chocolate's impact on low-grade endotoxemia in metabolic dysfunction-associated steatohepatitis","authors":"Arianna Pannunzio M.D. ,&nbsp;Francesco Baratta M.D. ,&nbsp;Enrico Maggio M.D. ,&nbsp;Ilaria Maria Palumbo M.D. ,&nbsp;Arianna Magna M.D. ,&nbsp;Chiara Trivigno M.D. ,&nbsp;Roberto Carnevale Ph.D. ,&nbsp;Bartimoccia Simona Ph.D. ,&nbsp;Vittoria Cammisotto Ph.D. ,&nbsp;Gianpaolo Vidili M.D. ,&nbsp;Pasquale Pignatelli M.D. ,&nbsp;Maria Del Ben M.D. ,&nbsp;Francesco Violi M.D. ,&nbsp;Lorenzo Loffredo M.D.","doi":"10.1016/j.nut.2024.112643","DOIUrl":"10.1016/j.nut.2024.112643","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Cocoa may have prebiotic effects and improve gut barrier function. However, it remains unclear whether dark chocolate can reduce lipopolysaccharide (LPS) levels in patients with metabolic dysfunction–associated steatohepatitis (MASH). This study aims to evaluate the effect of dark chocolate compared to milk chocolate on endotoxemia in patients with MASH.</div></div><div><h3>Methods and Results</h3><div>Nineteen patients with MASH were randomly assigned in a crossover design to consume either 40 g/d of dark chocolate (&gt;85% cocoa) or 40 g/d of milk chocolate (&lt;35% cocoa) for 2 weeks to evaluate circulating levels of LPS and zonulin. A significant difference between treatments was observed in LPS (<em>P</em> = 0.04) and zonulin (<em>P</em> = 0.02) levels based on the ANOVA conducted on the crossover study data. Pairwise comparisons revealed that, compared to baseline, after 14 days of dark chocolate consumption, LPS levels decreased from 22 ± 4 to 19 ± 4 pg/dL (–15%), and zonulin levels decreased from 3.2 ± 0.9 to 2.5 ± 0.8 pg/mL (–20%). Linear correlation analysis indicated that the change (Δ) in LPS values before and after chocolate intake correlated with the change (Δ) in zonulin levels (<em>R</em> = 0.340, <em>P</em> = 0.03).</div></div><div><h3>Conclusions</h3><div>This study demonstrates that dark chocolate reduces circulating levels of LPS and zonulin in patients with MASH.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"131 ","pages":"Article 112643"},"PeriodicalIF":3.2,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and factors associated with vitamin D deficiency in children and adolescents with type 1 diabetes mellitus: Baseline data from a clinical trial in Rio de Janeiro","authors":"Carolina Ferraz Figueiredo Moreira ,&nbsp;Ana Carolina Proença da Fonseca ,&nbsp;Aline Alves Ferreira ,&nbsp;Bárbara Folino Nascimento ,&nbsp;Beatriz Bastos de Araújo ,&nbsp;Dayana Rodrigues Farias ,&nbsp;Mario Campos Junior ,&nbsp;Jorge Luiz Luescher ,&nbsp;Patricia de Carvalho Padilha","doi":"10.1016/j.nut.2024.112634","DOIUrl":"10.1016/j.nut.2024.112634","url":null,"abstract":"<div><h3>Objectives</h3><div>The therapeutic potential of vitamin D has been studied regarding adjuvant interventions. Some studies have evaluated the factors associated with vitamin D deficiency (VDD) in healthy populations, but they are scarce in children and adolescents with type 1 diabetes mellitus (T1DM). The objective of this study was to describe the prevalence of and factors associated with VDD in children and adolescents with T1DM.</div></div><div><h3>Methods</h3><div>This was a cross-sectional analysis of the baseline data from a controlled clinical trial. Participants were between 7 and 16 y old, diagnosed with T1DM for at least 1 y, and classified as having VDD when 25-hydroxyvitamin D (25[OH]D) was less than 30 ng/mL. The following data were collected: sociodemographic, clinical, laboratory, lifestyle, anthropometric, and Fok-I polymorphism (rs2228570). A multivariable logistic regression model was developed to adjust the effect of potential confounders. The odds ratio (OR) with 95% confidence interval (CI) was used. The significance level used was 5%.</div></div><div><h3>Results</h3><div>A total of 143 children and adolescents were enrolled; 51% were female and the mean age was 11.5 ± 2.2 y old. The prevalence of VDD was 79% and the mean 25(OH)D of participants with VDD was 19.2 ± 6.1 ng/mL. The factors associated with VDD were low level of physical activity (OR, 2.9, 95% CI, 1.1–7.6, <em>P</em> = 0.031), poor glycemic control (OR, 5.0, 95% CI, 1.9–13.2, <em>P</em> = 0.001), and excess weight (OR, 3.6, 95% CI, 1.1–11.1, <em>P</em> = 0.029).</div></div><div><h3>Conclusions</h3><div>A high prevalence of VDD was observed as well as some associated lifestyle and clinical variables. Recommendations for children and adolescents with T1DM include monitoring their 25(OH)D and encouraging healthy eating practices and routine physical exercise.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"131 ","pages":"Article 112634"},"PeriodicalIF":3.2,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}