Pub Date : 2025-12-26DOI: 10.1016/j.nut.2025.113080
Luísa Martins Trindade, Amanda Dias Borges, Rodrigo Dias de Oliveira Carvalho, Bianca Fernandes Gomes, Mariana Teixeira da Silva, Nayara Salgado Vieira Sette, Luiza Rogério, Gregório Grama Cavalcanti, Ana Paula Vargas Garcia, Geovanni Dantas Cassali, Vasco Ariston Azevedo, Valbert Nascimento Cardoso, Sílvia Fernandes Maurício, Luciana Bastos Rodrigues, Samanta Thomas Valdés, Rodrigo Gomes da Silva, Simone de Vasconcelos Generoso
Background: Patients undergoing major surgeries, such as intestinal resections for colorectal cancer (CRC), present an increased risk of developing gut dysbiosis, which may be related to postoperative complications. However, biotherapeutic agents, such as symbiotics, are able to maintain intestinal homeostasis. We therefore explored the impact of preoperative symbiotic supplementation on the intestinal microbiota (IM) of patients with colorectal cancer undergoing surgical treatment.
Methods: This was a single-center, parallel, triple-masked, randomized clinical trial carried out at Federal University of Minas Gerais Hospital, Belo Horizonte, Minas Gerais, Brazil (https://clinicaltrials.gov/study/NCT04874883) comprised of adult patients diagnosed with CRC for tumor resection surgery. Patients were randomized to receive two sachets (6 g each) of symbiotic (S group) or maltodextrin (C group) twice a day for 4-10 d prior to surgery. All patients underwent nutritional and anthropometric assessments, as well as food consumption, bowel function, and digestive complaint assessments during the pre- and postoperative periods. Stools were collected before treatment (T1), after surgery (T2), and before hospital discharge (T3) to assess IM diversity and short-chain fatty acids. Normal tissue and tumor tissue fragments were collected during surgery for evaluation.
Results: A total of 46 patients were enrolled in the study, with 23 subjects in each group. No differences were seen between the groups regarding clinical or infectious complications (P > 0.05). The IM of stools collected at T2 showed a significant increment for the phylum Firmicutes, family Bacillaceae, and genus Blautia in the S group compared with the C group (P < 0.05). Furthermore, in those patients with infectious complications, the relative abundance of the Proteobacteria phylum was significantly lower in the S group compared with the C group (P < 0.05). Higher butyrate production was found at T2 and T3 in the S group, while acetate and propionate production were increased at T2 (P < 0.05). Additionally, the S group showed increased mucus production in the tumor tissue (P > 0.05).
Conclusion: Preoperative symbiotic supplementation in patients with CRC undergoing tumor resection positively altered IM diversity, and increased short-chain fatty acid and mucus production.
{"title":"Preoperative symbiotic supplementation modulates the intestinal microbiota of patients with colorectal cancer: Evidence from a randomized clinical trial.","authors":"Luísa Martins Trindade, Amanda Dias Borges, Rodrigo Dias de Oliveira Carvalho, Bianca Fernandes Gomes, Mariana Teixeira da Silva, Nayara Salgado Vieira Sette, Luiza Rogério, Gregório Grama Cavalcanti, Ana Paula Vargas Garcia, Geovanni Dantas Cassali, Vasco Ariston Azevedo, Valbert Nascimento Cardoso, Sílvia Fernandes Maurício, Luciana Bastos Rodrigues, Samanta Thomas Valdés, Rodrigo Gomes da Silva, Simone de Vasconcelos Generoso","doi":"10.1016/j.nut.2025.113080","DOIUrl":"https://doi.org/10.1016/j.nut.2025.113080","url":null,"abstract":"<p><strong>Background: </strong>Patients undergoing major surgeries, such as intestinal resections for colorectal cancer (CRC), present an increased risk of developing gut dysbiosis, which may be related to postoperative complications. However, biotherapeutic agents, such as symbiotics, are able to maintain intestinal homeostasis. We therefore explored the impact of preoperative symbiotic supplementation on the intestinal microbiota (IM) of patients with colorectal cancer undergoing surgical treatment.</p><p><strong>Methods: </strong>This was a single-center, parallel, triple-masked, randomized clinical trial carried out at Federal University of Minas Gerais Hospital, Belo Horizonte, Minas Gerais, Brazil (https://clinicaltrials.gov/study/NCT04874883) comprised of adult patients diagnosed with CRC for tumor resection surgery. Patients were randomized to receive two sachets (6 g each) of symbiotic (S group) or maltodextrin (C group) twice a day for 4-10 d prior to surgery. All patients underwent nutritional and anthropometric assessments, as well as food consumption, bowel function, and digestive complaint assessments during the pre- and postoperative periods. Stools were collected before treatment (T1), after surgery (T2), and before hospital discharge (T3) to assess IM diversity and short-chain fatty acids. Normal tissue and tumor tissue fragments were collected during surgery for evaluation.</p><p><strong>Results: </strong>A total of 46 patients were enrolled in the study, with 23 subjects in each group. No differences were seen between the groups regarding clinical or infectious complications (P > 0.05). The IM of stools collected at T2 showed a significant increment for the phylum Firmicutes, family Bacillaceae, and genus Blautia in the S group compared with the C group (P < 0.05). Furthermore, in those patients with infectious complications, the relative abundance of the Proteobacteria phylum was significantly lower in the S group compared with the C group (P < 0.05). Higher butyrate production was found at T2 and T3 in the S group, while acetate and propionate production were increased at T2 (P < 0.05). Additionally, the S group showed increased mucus production in the tumor tissue (P > 0.05).</p><p><strong>Conclusion: </strong>Preoperative symbiotic supplementation in patients with CRC undergoing tumor resection positively altered IM diversity, and increased short-chain fatty acid and mucus production.</p>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"145 ","pages":"113080"},"PeriodicalIF":3.0,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-26DOI: 10.1016/j.nut.2025.113081
Daniel de Luis, David Primo, Olatz Izaola, Angela Cebria, Eduardo Godoy, Juan José López Gómez
Objectives: Follistatin-like protein-1 (FSTL-1) is emerging as a myokine linking skeletal and muscle biology. We investigated the relationship between circulating FSTL-1 levels and muscle mass and quality, using an artificial intelligence (AI)-enhanced ultrasonographic evaluation of the rectus femoris in patients with cancer-related disease-related malnutrition.
Methods: A total of 91 patients diagnosed with cancer and disease-related malnutrition were included in the study. Muscle mass assessment was performed through US evaluation of the rectus femoris, using an AI-based analytical ultrasound system. Complementary evaluations comprised BIA to determine skeletal muscle mass, appendicular skeletal muscle mass, and the appendicular skeletal muscle mass index, with determination of circulating FSTL-1 concentrations.
Results: Thirty-seven women and 54 men, with a mean age of 69.5 ± 10.6 years were enrolled. Sarcopenia was identified in 41 individuals (45.9%). Patients with sarcopenia showed significantly reduced values: body weight (-4.1 ± 1.0 kg; P = 0.02), calf circumference (-2.5 ± 0.3 cm; P = 0.03), phase angle (-0.7 ± 0.2°; P = 0.01), and reactance (-6.3 ± 1.3 Ω; P = 0.03), skeletal muscle mass (-2.3 ± 0.3 kg; P = 0.03), appendicular skeletal muscle mass (-3.7 ± 0.1 kg; P = 0.02), and appendicular skeletal muscle mass index (-1.3 ± 0.3 kg/m²; P = 0.02), cross-sectional area (-0.4 ± 0.2 cm²; P = 0.04), and y-axis (-0.27 ± 0.1 cm; P = 0.03), and pennation angle (-1.1 ± 0.2°; P = 0.02). Circulating levels of FSTL-1 were markedly reduced in patients with sarcopenia. In the multivariate logistic regression model, lower FSTL-1 concentrations remained significantly associated with an increased likelihood of sarcopenia (OR = 1.63, 95% CI: 1.10-4.21; P = 0.03. FSTL-1 demonstrated a moderate discriminative capacity for identifying sarcopenia, with an area under the receiver operating characteristic curve of 0.69 (95% CI: 0.51-0.73; P = 0.03).
Conclusions: Reduced circulating FSTL-1 levels were independently associated with sarcopenia in patients with cancer-related malnutrition. These results indicate that FSTL-1 may act as a biomarker of impaired muscle quality and mass, as reflected by AI-assisted ultrasound and bioimpedance parameters.
{"title":"Serum FSTL-1 and AI-assessed muscle parameters in cancer-related malnutrition.","authors":"Daniel de Luis, David Primo, Olatz Izaola, Angela Cebria, Eduardo Godoy, Juan José López Gómez","doi":"10.1016/j.nut.2025.113081","DOIUrl":"https://doi.org/10.1016/j.nut.2025.113081","url":null,"abstract":"<p><strong>Objectives: </strong>Follistatin-like protein-1 (FSTL-1) is emerging as a myokine linking skeletal and muscle biology. We investigated the relationship between circulating FSTL-1 levels and muscle mass and quality, using an artificial intelligence (AI)-enhanced ultrasonographic evaluation of the rectus femoris in patients with cancer-related disease-related malnutrition.</p><p><strong>Methods: </strong>A total of 91 patients diagnosed with cancer and disease-related malnutrition were included in the study. Muscle mass assessment was performed through US evaluation of the rectus femoris, using an AI-based analytical ultrasound system. Complementary evaluations comprised BIA to determine skeletal muscle mass, appendicular skeletal muscle mass, and the appendicular skeletal muscle mass index, with determination of circulating FSTL-1 concentrations.</p><p><strong>Results: </strong>Thirty-seven women and 54 men, with a mean age of 69.5 ± 10.6 years were enrolled. Sarcopenia was identified in 41 individuals (45.9%). Patients with sarcopenia showed significantly reduced values: body weight (-4.1 ± 1.0 kg; P = 0.02), calf circumference (-2.5 ± 0.3 cm; P = 0.03), phase angle (-0.7 ± 0.2°; P = 0.01), and reactance (-6.3 ± 1.3 Ω; P = 0.03), skeletal muscle mass (-2.3 ± 0.3 kg; P = 0.03), appendicular skeletal muscle mass (-3.7 ± 0.1 kg; P = 0.02), and appendicular skeletal muscle mass index (-1.3 ± 0.3 kg/m²; P = 0.02), cross-sectional area (-0.4 ± 0.2 cm²; P = 0.04), and y-axis (-0.27 ± 0.1 cm; P = 0.03), and pennation angle (-1.1 ± 0.2°; P = 0.02). Circulating levels of FSTL-1 were markedly reduced in patients with sarcopenia. In the multivariate logistic regression model, lower FSTL-1 concentrations remained significantly associated with an increased likelihood of sarcopenia (OR = 1.63, 95% CI: 1.10-4.21; P = 0.03. FSTL-1 demonstrated a moderate discriminative capacity for identifying sarcopenia, with an area under the receiver operating characteristic curve of 0.69 (95% CI: 0.51-0.73; P = 0.03).</p><p><strong>Conclusions: </strong>Reduced circulating FSTL-1 levels were independently associated with sarcopenia in patients with cancer-related malnutrition. These results indicate that FSTL-1 may act as a biomarker of impaired muscle quality and mass, as reflected by AI-assisted ultrasound and bioimpedance parameters.</p>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"145 ","pages":"113081"},"PeriodicalIF":3.0,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24DOI: 10.1016/j.nut.2025.113082
Em Canh Pham M.Pharm. , Tuong Vi Thi Le M.Pharm. , Tuoi Thi Hong Do Ph.D. , Thanh Chi Le M.P.H. , Hien Duc Le B.Pharm. , Nam Tran Nguyen M.D. , Tien Minh Nguyen M.D.
Objectives
Dietary supplements (DS) are increasingly used in pediatric care to address nutritional deficiencies and support treatment, yet their prescribing patterns in low- and middle-income settings are understudied. The aim of this study was to characterize patterns of pediatric DS use and to evaluate the appropriateness of prescribing practices.
Methods
A 2024 cross-sectional study of 1000 Vietnamese pediatric outpatients examined DS use by age, nutritional status, and disease, and assessed age and dosage adherence.
Results
Monotherapy dominated (69.0%), primarily in children aged 1–10 y (53.1%), with probiotics (20.5%) and multivitamin–mineral–amino acid complexes (8.1%) prevalent, driven by respiratory (58.8%) and infectious diagnoses. Poly-supplementation (31.0%) was common in mid-childhood, with zinc–probiotic combinations (4.8%) addressing multifaceted needs; however, complex regimens posed dosing challenges. Nutritional status revealed conservative prescribing, with underweight children (6.9%) receiving minimal DS despite evidence supporting multi-nutrient interventions for growth recovery. Age appropriateness was high (99.1%), with minor deviations in infants (0.5%) linked to digestive disorders (adjusted OR = 22.90, P = 0.0006). Dosage compliance was lower (91.0%), with 9.0% exceedances, particularly in complex formulations (e.g., 24.8% for multivitamins–minerals–amino acids). Normal-weight children (74.5%) dominated DS use, reflecting demographic proportionality rather than targeted needs, while overweight (18.6%) and underweight groups showed potential underutilization of corrective DS, such as zinc for malnutrition or vitamin D for obesity-related deficits. Logistic regression highlighted prescription multiplicity (dual DS: adjusted OR = 1.85, P = 0.0150; triple DS: adjusted OR = 2.72, P = 0.0226) and digestive diagnoses as key non-compliance predictors.
Conclusions
These findings underscore a probiotic-centric, conservative DS paradigm, with gaps in addressing high-risk groups and dosing accuracy. Enhanced guidelines, clinician training, and electronic prescribing tools are critical to optimize DS efficacy and safety, aligning with evidence-based standards to improve pediatric outcomes in resource-constrained contexts.
膳食补充剂（DS）越来越多地用于儿科护理，以解决营养缺乏和支持治疗，但其在低收入和中等收入环境中的处方模式尚未得到充分研究。本研究的目的是表征儿童DS使用的模式，并评估处方实践的适当性。方法对1000名越南儿科门诊患者进行2024年横断面研究，根据年龄、营养状况和疾病情况检查DS的使用情况，并评估年龄和剂量依从性。结果单药治疗占主导地位（69.0%），以1-10岁儿童为主（53.1%），其次是益生菌（20.5%）和多种维生素-矿物质-氨基酸复合物（8.1%），其次是呼吸道（58.8%）和感染性诊断。复合补充剂（31.0%）在儿童中期很常见，锌-益生菌组合（4.8%）解决了多方面的需求；然而，复杂的治疗方案带来了剂量方面的挑战。营养状况显示处方保守，体重不足的儿童（6.9%）接受最低限度的退行性退行，尽管有证据支持多种营养干预以促进生长恢复。年龄适宜性高（99.1%），与消化系统疾病相关的婴儿有轻微偏差（0.5%）（校正OR = 22.90, P = 0.0006）。剂量依从性较低（91.0%），超过9.0%，特别是在复杂配方中（例如，复合维生素-矿物质-氨基酸为24.8%）。体重正常的儿童（74.5%）主要使用补给品，这反映了人口比例而非目标需求，而超重（18.6%）和体重不足的儿童显示出对纠正补给品的潜在利用不足，如锌治疗营养不良或维生素D治疗肥胖相关缺陷。Logistic回归强调处方多重性（双DS：调整OR = 1.85, P = 0.0150；三DS：调整OR = 2.72, P = 0.0226）和消化诊断是关键的不合规预测因素。这些发现强调了以益生菌为中心的保守DS模式，在高危人群和剂量准确性方面存在差距。加强指南、临床医生培训和电子处方工具对于优化DS的有效性和安全性至关重要，并与循证标准保持一致，以改善资源受限环境下的儿科结果。
{"title":"Prescribing patterns and appropriateness of dietary supplements in pediatric outpatients by age, nutritional status, and clinical diagnoses","authors":"Em Canh Pham M.Pharm. , Tuong Vi Thi Le M.Pharm. , Tuoi Thi Hong Do Ph.D. , Thanh Chi Le M.P.H. , Hien Duc Le B.Pharm. , Nam Tran Nguyen M.D. , Tien Minh Nguyen M.D.","doi":"10.1016/j.nut.2025.113082","DOIUrl":"10.1016/j.nut.2025.113082","url":null,"abstract":"<div><h3>Objectives</h3><div>Dietary supplements (DS) are increasingly used in pediatric care to address nutritional deficiencies and support treatment, yet their prescribing patterns in low- and middle-income settings are understudied. The aim of this study was to characterize patterns of pediatric DS use and to evaluate the appropriateness of prescribing practices.</div></div><div><h3>Methods</h3><div>A 2024 cross-sectional study of 1000 Vietnamese pediatric outpatients examined DS use by age, nutritional status, and disease, and assessed age and dosage adherence.</div></div><div><h3>Results</h3><div>Monotherapy dominated (69.0%), primarily in children aged 1–10 y (53.1%), with probiotics (20.5%) and multivitamin–mineral–amino acid complexes (8.1%) prevalent, driven by respiratory (58.8%) and infectious diagnoses. Poly-supplementation (31.0%) was common in mid-childhood, with zinc–probiotic combinations (4.8%) addressing multifaceted needs; however, complex regimens posed dosing challenges. Nutritional status revealed conservative prescribing, with underweight children (6.9%) receiving minimal DS despite evidence supporting multi-nutrient interventions for growth recovery. Age appropriateness was high (99.1%), with minor deviations in infants (0.5%) linked to digestive disorders (adjusted OR = 22.90, <em>P</em> = 0.0006). Dosage compliance was lower (91.0%), with 9.0% exceedances, particularly in complex formulations (e.g., 24.8% for multivitamins–minerals–amino acids). Normal-weight children (74.5%) dominated DS use, reflecting demographic proportionality rather than targeted needs, while overweight (18.6%) and underweight groups showed potential underutilization of corrective DS, such as zinc for malnutrition or vitamin D for obesity-related deficits. Logistic regression highlighted prescription multiplicity (dual DS: adjusted OR = 1.85, <em>P</em> = 0.0150; triple DS: adjusted OR = 2.72, <em>P</em> = 0.0226) and digestive diagnoses as key non-compliance predictors.</div></div><div><h3>Conclusions</h3><div>These findings underscore a probiotic-centric, conservative DS paradigm, with gaps in addressing high-risk groups and dosing accuracy. Enhanced guidelines, clinician training, and electronic prescribing tools are critical to optimize DS efficacy and safety, aligning with evidence-based standards to improve pediatric outcomes in resource-constrained contexts.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"145 ","pages":"Article 113082"},"PeriodicalIF":3.0,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146036641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24DOI: 10.1016/j.nut.2025.113079
Natasha Nalucha Mwala M.Sc. , Jos W. Borkent Ph.D. , Barbara S. van der Meij Ph.D. , Marian A.E. de van der Schueren Ph.D.
Objectives
Unintentional weight loss (UWL) is an important clinical indicator of malnutrition risk. Risk factors for UWL may differ by body size, measured by body mass index (BMI), and identifying at-risk individuals can be challenging in those with overweight/obesity.
Methods
Data from ∼125 000 adults (≥18 y) in the Dutch Lifelines cohort were analyzed to examine whether associations between 21 potential risk factors spanning sociodemographic, psychological stress, disease, dietary, and quality-of-life domains and UWL differ by BMI group. Participants were classified as having a healthy weight (45.8%) or overweight/obesity (54.2%). Multivariable Poisson regression models estimated prevalence ratios for UWL, with sensitivity analyses to test robustness. Statistical significance was set at P < 0.05.
Results
UWL was reported by 4.9% of participants with a healthy weight and 2.7% of those with overweight/obesity. Positive associations with UWL were observed for female sex, (healthy-weight group only), absence from work due to disease, psychological stress in the past year, chronic obstructive pulmonary disease, depression, and poor quality-of-life indicators (physical functioning, perceived health, emotional well-being, vitality, and social functioning). Effect modification by BMI was suggested for 10 risk factors (P < 0.1), with associations generally more pronounced in the healthy-weight group. After sensitivity analyses, only higher educational attainment, psychological stress in the past year, and poor physical functioning retained significant modification.
Conclusions
Most risk factors for UWL were consistent between BMI groups. Differences in higher educational attainment, psychological stress in the past year, and physical functioning suggest that although the factors are similar, their impact may differ by BMI.
{"title":"Unintentional weight loss: Most risk factors do not differ between individuals with a healthy weight and those with overweight or obesity","authors":"Natasha Nalucha Mwala M.Sc. , Jos W. Borkent Ph.D. , Barbara S. van der Meij Ph.D. , Marian A.E. de van der Schueren Ph.D.","doi":"10.1016/j.nut.2025.113079","DOIUrl":"10.1016/j.nut.2025.113079","url":null,"abstract":"<div><h3>Objectives</h3><div>Unintentional weight loss (UWL) is an important clinical indicator of malnutrition risk. Risk factors for UWL may differ by body size, measured by body mass index (BMI), and identifying at-risk individuals can be challenging in those with overweight/obesity.</div></div><div><h3>Methods</h3><div>Data from ∼125 000 adults (≥18 y) in the Dutch Lifelines cohort were analyzed to examine whether associations between 21 potential risk factors spanning sociodemographic, psychological stress, disease, dietary, and quality-of-life domains and UWL differ by BMI group. Participants were classified as having a healthy weight (45.8%) or overweight/obesity (54.2%). Multivariable Poisson regression models estimated prevalence ratios for UWL, with sensitivity analyses to test robustness. Statistical significance was set at <em>P</em> < 0.05.</div></div><div><h3>Results</h3><div>UWL was reported by 4.9% of participants with a healthy weight and 2.7% of those with overweight/obesity. Positive associations with UWL were observed for female sex, (healthy-weight group only), absence from work due to disease, psychological stress in the past year, chronic obstructive pulmonary disease, depression, and poor quality-of-life indicators (physical functioning, perceived health, emotional well-being, vitality, and social functioning). Effect modification by BMI was suggested for 10 risk factors (<em>P</em> < 0.1), with associations generally more pronounced in the healthy-weight group. After sensitivity analyses, only higher educational attainment, psychological stress in the past year, and poor physical functioning retained significant modification.</div></div><div><h3>Conclusions</h3><div>Most risk factors for UWL were consistent between BMI groups. Differences in higher educational attainment, psychological stress in the past year, and physical functioning suggest that although the factors are similar, their impact may differ by BMI.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"145 ","pages":"Article 113079"},"PeriodicalIF":3.0,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24DOI: 10.1016/j.nut.2025.113083
Piotr Wlaź DVM, PhD , Karolina Skonieczna-Żydecka PhD , Adrian Wiater PhD , Daniel Styburski PhD , Małgorzata Majewska PhD , Anna Boguszewska-Czubara MD, PhD , Elżbieta Wyska PhD , Alan González-Ibarra PhD , Nikola Gapińska MSc , Dorota Luchowska-Kocot MD, PhD , Renata Żelazowska MD, PhD , Marcin Grąz PhD , Katarzyna Socała PhD
Objective
Accumulating preclinical and clinical evidence suggests potential beneficial effects of probiotic supplementation in the management of epilepsy. Here, we aimed to investigate the effect of two distinct bacterial strains, Bifidobacterium longum R0175 and Lacticaseibacillus rhamnosus JB-1, on seizure susceptibility, the antiseizure efficacy of sodium valproate, behavioral and neurochemical parameters, and gut metabolomic profiles in mice.
Methods
Mice received daily oral administration of either B. longum R0175 or L. rhamnosus JB-1 for 28 d. Seizure thresholds were assessed using the maximal electroshock seizure threshold (MEST) test, the 6 Hz seizure threshold test, and the intravenous (iv) pentylenetetrazole (PTZ) seizure test. The efficacy of sodium valproate was evaluated in the subcutaneous (sc) PTZ seizure test. Additional assessments included anxiety-related behavior, neuromotor functions, brain neurochemical and inflammatory markers, fecal short-chain fatty acids (SCFAs), and untargeted metabolomic profiling of fecal samples.
Results
B. longum R0175 and L. rhamnosus JB-1 did not affect the thresholds for tonic seizures in the MEST test and for psychomotor seizures in the 6 Hz test. B. longum R0175 slightly increased the threshold for myoclonic seizures in the ivPTZ. Both strains enhanced the antiseizure efficacy of sodium valproate without altering its serum or brain concentrations. No significant effects were observed on anxiety-related behavior, neuromotor function, neurochemical or inflammatory markers. Both probiotics increased the concentration of butyrate and total SCFAs in fecal samples. Metabolomic analysis revealed variations in the metabolism of bile acids, polyphenols, fatty acids, and amino acids.
Conclusions
The probiotics alone had minimal effects on seizure thresholds, but they enhanced the antiseizure efficacy of valproate, which may be linked to increased SCFA production and altered gut metabolism. These findings support further studies on probiotics as a complementary strategy in epilepsy treatment.
{"title":"Influence of dietary supplementation with two distinct probiotic strains, Bifidobacterium longum R0175 and Lacticaseibacillus rhamnosus JB-1, on seizure susceptibility and valproate response: Behavioral and biochemical studies in mice","authors":"Piotr Wlaź DVM, PhD , Karolina Skonieczna-Żydecka PhD , Adrian Wiater PhD , Daniel Styburski PhD , Małgorzata Majewska PhD , Anna Boguszewska-Czubara MD, PhD , Elżbieta Wyska PhD , Alan González-Ibarra PhD , Nikola Gapińska MSc , Dorota Luchowska-Kocot MD, PhD , Renata Żelazowska MD, PhD , Marcin Grąz PhD , Katarzyna Socała PhD","doi":"10.1016/j.nut.2025.113083","DOIUrl":"10.1016/j.nut.2025.113083","url":null,"abstract":"<div><h3>Objective</h3><div>Accumulating preclinical and clinical evidence suggests potential beneficial effects of probiotic supplementation in the management of epilepsy. Here, we aimed to investigate the effect of two distinct bacterial strains, <em>Bifidobacterium longum</em> R0175 and <em>Lacticaseibacillus rhamnosus</em> JB-1, on seizure susceptibility, the antiseizure efficacy of sodium valproate, behavioral and neurochemical parameters, and gut metabolomic profiles in mice.</div></div><div><h3>Methods</h3><div>Mice received daily oral administration of either <em>B. longum</em> R0175 or <em>L. rhamnosus</em> JB-1 for 28 d. Seizure thresholds were assessed using the maximal electroshock seizure threshold (MEST) test, the 6 Hz seizure threshold test, and the intravenous (<em>iv</em>) pentylenetetrazole (PTZ) seizure test. The efficacy of sodium valproate was evaluated in the subcutaneous (<em>sc</em>) PTZ seizure test. Additional assessments included anxiety-related behavior, neuromotor functions, brain neurochemical and inflammatory markers, fecal short-chain fatty acids (SCFAs), and untargeted metabolomic profiling of fecal samples.</div></div><div><h3>Results</h3><div><em>B. longum</em> R0175 and <em>L. rhamnosus</em> JB-1 did not affect the thresholds for tonic seizures in the MEST test and for psychomotor seizures in the 6 Hz test. <em>B. longum</em> R0175 slightly increased the threshold for myoclonic seizures in the <em>iv</em>PTZ. Both strains enhanced the antiseizure efficacy of sodium valproate without altering its serum or brain concentrations. No significant effects were observed on anxiety-related behavior, neuromotor function, neurochemical or inflammatory markers. Both probiotics increased the concentration of butyrate and total SCFAs in fecal samples. Metabolomic analysis revealed variations in the metabolism of bile acids, polyphenols, fatty acids, and amino acids.</div></div><div><h3>Conclusions</h3><div>The probiotics alone had minimal effects on seizure thresholds, but they enhanced the antiseizure efficacy of valproate, which may be linked to increased SCFA production and altered gut metabolism. These findings support further studies on probiotics as a complementary strategy in epilepsy treatment.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"145 ","pages":"Article 113083"},"PeriodicalIF":3.0,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146036716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutritional therapy is crucial for managing chronic kidney disease (CKD), with protein restriction in the non-dialysis stages being vital for slowing disease progression. Moreover, limiting ultra-processed foods (UPF) is necessary due to the health risks associated with these foods, including the advancement of CKD. This study aims to evaluate the impact of routine nutritional care on UPF intake and biochemical markers in non-dialysis CKD patients.
Methods
Dietary intake, anthropometric, and biochemical data were measured at baseline and post-1 mo of routine nutritional care for patients with non-dialysis CKD patients. Dietary intake data were collected using a 24-h dietary recall and a Food Frequency Questionnaire. NOVA classification was used to evaluate UPF intake.
Results
The study included 83 participants (53% men; 62 [25.5] years old; body mass index 29 [6.77] kg/m2; estimated glomerular filtration rate of 36 [25.6] mL/min/1.73 m2). After 1 mo of the nutritional intervention, there was significantly decreased caloric intake from UPF (P = 0.011) globally. In addition, patients with adequate protein intake showed decreased UPF intake and increased intake of in natura and minimally processed foods compared to those with inadequate protein intake (P < 0.05). There was an increase in the estimated glomerular filtration rate (P < 0.001) and albumin (P = 0.009) after 1 mo. A reduction in serum potassium levels (P = 0.013), sodium (P = 0.007), glucose (P = 0.018), and glycated hemoglobin (P = 0.021) was also observed.
Conclusions
The 1-mo nutritional intervention reduced the intake of UPF and increased intake of in natura and minimally processed foods, improving biochemical parameters in non-dialysis CKD patients.
{"title":"Short-term effects of routine nutritional care on dietary patterns and biochemical parameters in non-dialysis chronic kidney disease patients","authors":"Larissa Braga Lisboa M.Sc. , Lyandra Pereira da Silva B.Sc. , Isabela S.C. Brum M.Sc. , Marcelo Ribeiro-Alves Ph.D. , Ludmila FMF Cardozo Ph.D. , Denise Mafra Ph.D. , Livia Alvarenga Ph.D.","doi":"10.1016/j.nut.2025.113073","DOIUrl":"10.1016/j.nut.2025.113073","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Nutritional therapy is crucial for managing chronic kidney disease (CKD), with protein restriction in the non-dialysis stages being vital for slowing disease progression. Moreover, limiting ultra-processed foods (UPF) is necessary due to the health risks associated with these foods, including the advancement of CKD. This study aims to evaluate the impact of routine nutritional care on UPF intake and biochemical markers in non-dialysis CKD patients.</div></div><div><h3>Methods</h3><div>Dietary intake, anthropometric, and biochemical data were measured at baseline and post-1 mo of routine nutritional care for patients with non-dialysis CKD patients. Dietary intake data were collected using a 24-h dietary recall and a Food Frequency Questionnaire. NOVA classification was used to evaluate UPF intake.</div></div><div><h3>Results</h3><div>The study included 83 participants (53% men; 62 [25.5] years old; body mass index 29 [6.77] kg/m<sup>2</sup>; estimated glomerular filtration rate of 36 [25.6] mL/min/1.73 m<sup>2</sup>). After 1 mo of the nutritional intervention, there was significantly decreased caloric intake from UPF (<em>P</em> = 0.011) globally. In addition, patients with adequate protein intake showed decreased UPF intake and increased intake of <em>in natura</em> and minimally processed foods compared to those with inadequate protein intake (<em>P</em> < 0.05). There was an increase in the estimated glomerular filtration rate (<em>P</em> < 0.001) and albumin (<em>P</em> = 0.009) after 1 mo. A reduction in serum potassium levels (<em>P</em> = 0.013), sodium (<em>P</em> = 0.007), glucose (<em>P</em> = 0.018), and glycated hemoglobin (<em>P</em> = 0.021) was also observed.</div></div><div><h3>Conclusions</h3><div>The 1-mo nutritional intervention reduced the intake of UPF and increased intake of <em>in natura</em> and minimally processed foods, improving biochemical parameters in non-dialysis CKD patients.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"144 ","pages":"Article 113073"},"PeriodicalIF":3.0,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146019495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-23DOI: 10.1016/j.nut.2025.113084
Pincheng Luo M.B., B.Ch., B.A.O. , Shanshan Cai Ph.D. , Huanlin Zhou B.S. , Junhui Zhu M.Ed. , Yule Yang M.Ed. , Yanxue Lian Ph.D.
Objectives
To examine the association between a novel sarcopenia index and cancer incidence among Chinese adults aged ≥45 y.
Methods
Data were derived from the China Health and Retirement Longitudinal Study. The sarcopenia index was calculated as the ratio of serum creatinine (mg/L) to serum cystatin C (mg/L), multiplied by 100. Incident cancer was identified through self-reported physician diagnosis. Cox proportional hazards models were used to estimate the association between the sarcopenia index and cancer risk, evaluated both continuously and by tertiles. Dose–response and linearity were assessed using restricted cubic spline regression and likelihood ratio tests, respectively.
Results
A total of 10 446 participants (median age, 59 y) were included. During a median follow-up of 8.92 y, 248 participants developed cancer. The sarcopenia index was linearly associated with cancer risk. Each 1.0–SD increase in the index was associated with a 2% reduction in cancer risk. Compared with the lowest tertile (T1), adjusted hazard ratios (HRs) were 0.97 (95% CI, 0.73–1.29; P = 0.83) for T2 and 0.58 (95% CI, 0.41–0.83; P < 0.01) for T3 (P for trend < 0.01). Using T3 as the reference, HRs were 1.67 (95% CI, 1.18–2.36; P < 0.01) for T2 and 1.72 (95% CI, 1.21–2.46; P < 0.01) for T1 (P for trend < 0.01).
Conclusions
A significant inverse association was observed between the sarcopenia index and incident cancer risk in middle-aged and older adults, highlighting the potential role of skeletal muscle health in cancer prevention.
目的探讨中国≥45岁成人中新型肌肉减少症指数与癌症发病率的关系。方法数据来源于中国健康与退休纵向研究。肌少症指数计算为血清肌酐（mg/L）与血清胱抑素C （mg/L）之比乘以100。偶发性癌症是通过自我报告的医生诊断来确定的。Cox比例风险模型用于估计肌肉减少症指数与癌症风险之间的关系，采用连续评估和按位数评估两种方法。剂量-响应和线性分别采用限制三次样条回归和似然比检验进行评估。结果共纳入10446例受试者，中位年龄59岁。在平均8.92年的随访期间，248名参与者患上了癌症。肌肉减少指数与癌症风险呈线性相关。该指数每增加1.0个标准差，癌症风险就会降低2%。与最低分位数（T1）相比，T2的校正风险比（hr）为0.97 (95% CI, 0.73-1.29; P = 0.83)， T3的校正风险比（hr）为0.58 (95% CI, 0.41-0.83; P < 0.01) （P为趋势值<； 0.01）。以T3为参照，T2的hr为1.67 (95% CI, 1.18-2.36; P < 0.01)， T1的hr为1.72 (95% CI, 1.21-2.46; P < 0.01) （P为趋势；lt; 0.01）。结论中老年人骨骼肌减少指数与癌症发生风险呈显著负相关，提示骨骼肌健康在预防癌症中的潜在作用。
{"title":"Association between sarcopenia index based on the serum creatinine to cystatin C ratio and cancer incidence in middle-aged and older adults in China: A nationwide cohort study","authors":"Pincheng Luo M.B., B.Ch., B.A.O. , Shanshan Cai Ph.D. , Huanlin Zhou B.S. , Junhui Zhu M.Ed. , Yule Yang M.Ed. , Yanxue Lian Ph.D.","doi":"10.1016/j.nut.2025.113084","DOIUrl":"10.1016/j.nut.2025.113084","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine the association between a novel sarcopenia index and cancer incidence among Chinese adults aged ≥45 y.</div></div><div><h3>Methods</h3><div>Data were derived from the China Health and Retirement Longitudinal Study. The sarcopenia index was calculated as the ratio of serum creatinine (mg/L) to serum cystatin C (mg/L), multiplied by 100. Incident cancer was identified through self-reported physician diagnosis. Cox proportional hazards models were used to estimate the association between the sarcopenia index and cancer risk, evaluated both continuously and by tertiles. Dose–response and linearity were assessed using restricted cubic spline regression and likelihood ratio tests, respectively.</div></div><div><h3>Results</h3><div>A total of 10 446 participants (median age, 59 y) were included. During a median follow-up of 8.92 y, 248 participants developed cancer. The sarcopenia index was linearly associated with cancer risk. Each 1.0–SD increase in the index was associated with a 2% reduction in cancer risk. Compared with the lowest tertile (T1), adjusted hazard ratios (HRs) were 0.97 (95% CI, 0.73–1.29; <em>P</em> = 0.83) for T2 and 0.58 (95% CI, 0.41–0.83; <em>P</em> < 0.01) for T3 (<em>P</em> for trend < 0.01). Using T3 as the reference, HRs were 1.67 (95% CI, 1.18–2.36; <em>P</em> < 0.01) for T2 and 1.72 (95% CI, 1.21–2.46; <em>P</em> < 0.01) for T1 (<em>P</em> for trend < 0.01).</div></div><div><h3>Conclusions</h3><div>A significant inverse association was observed between the sarcopenia index and incident cancer risk in middle-aged and older adults, highlighting the potential role of skeletal muscle health in cancer prevention.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"145 ","pages":"Article 113084"},"PeriodicalIF":3.0,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of this study was to investigate the trajectory of malnutrition and predictors during chemotherapy among adults with cancer.
Methods
A prospective longitudinal study was conducted on 400 adults from February 2024 to April 2025. Measurements were taken at three intervals: prior to initiation of chemotherapy (T0), midcycle (T1), and upon completion of treatment (T2). Nutritional status was evaluated using the Patient-Generated Subjective Global Assessment. A mixed-effects ordinal regression was employed to identify the trend and predictors of malnutrition.
Results
Overall, 38% of patients did not complete chemotherapy. Among the sub-cohorts that completed treatment, severe malnutrition was 39% at baseline (T0), 37.5% midcycle (T1), and 31.7% end-cycle (T2), showing no significant change (P = 0.867). However, the prevalence of underweight (BMI < 18.5 kg/m²) and thinness (midupper arm circumference [MUAC] < 24 cm) declined significantly during chemotherapy. Severe malnutrition was associated with lack of physical activity (AOR = 1.95), low MUAC (AOR = 3.26), upper GI cancer (AOR = 11.3), comorbidities (AOR = 2.93), poor dietary diversity (AOR = 2.62), anemia (AOR = 1.86), and poor ECOG (AOR = 2.28). Conversely, prior surgery (AOR = 0.37) reduced the odds of severe malnutrition. Moreover, severe malnutrition at chemotherapy initiation increased the risk of dropout from treatment (AOR = 2.0).
Conclusions
Given the attrition among nutritionally vulnerable groups, it was observed that within the sub-groups that completed treatment, nutritional status remained stable, while BMI and MUAC showed improvements. These findings underscore the critical importance of early and regular nutritional assessments and addressing modifiable risk factors.
{"title":"Trends and predictors of malnutrition during chemotherapy among adults with cancer in Ethiopia: A prospective longitudinal study","authors":"Awole Seid MSc , Zelalem Debebe MD , Abebe Ayelign PhD , Bilal Shikur Endris PhD , Mathewos Assefa MD , Ahmedin Jemal PhD","doi":"10.1016/j.nut.2025.113075","DOIUrl":"10.1016/j.nut.2025.113075","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this study was to investigate the trajectory of malnutrition and predictors during chemotherapy among adults with cancer.</div></div><div><h3>Methods</h3><div>A prospective longitudinal study was conducted on 400 adults from February 2024 to April 2025. Measurements were taken at three intervals: prior to initiation of chemotherapy (<em>T</em><sub>0</sub>), midcycle (<em>T</em><sub>1</sub>), and upon completion of treatment (<em>T</em><sub>2</sub>). Nutritional status was evaluated using the Patient-Generated Subjective Global Assessment. A mixed-effects ordinal regression was employed to identify the trend and predictors of malnutrition.</div></div><div><h3>Results</h3><div>Overall, 38% of patients did not complete chemotherapy. Among the sub-cohorts that completed treatment, severe malnutrition was 39% at baseline (<em>T</em><sub>0</sub>), 37.5% midcycle (<em>T</em><sub>1</sub>), and 31.7% end-cycle (<em>T</em><sub>2</sub>), showing no significant change (<em>P</em> = 0.867). However, the prevalence of underweight (BMI < 18.5 kg/m²) and thinness (midupper arm circumference [MUAC] < 24 cm) declined significantly during chemotherapy. Severe malnutrition was associated with lack of physical activity (AOR = 1.95), low MUAC (AOR = 3.26), upper GI cancer (AOR = 11.3), comorbidities (AOR = 2.93), poor dietary diversity (AOR = 2.62), anemia (AOR = 1.86), and poor ECOG (AOR = 2.28). Conversely, prior surgery (AOR = 0.37) reduced the odds of severe malnutrition. Moreover, severe malnutrition at chemotherapy initiation increased the risk of dropout from treatment (AOR = 2.0).</div></div><div><h3>Conclusions</h3><div>Given the attrition among nutritionally vulnerable groups, it was observed that within the sub-groups that completed treatment, nutritional status remained stable, while BMI and MUAC showed improvements. These findings underscore the critical importance of early and regular nutritional assessments and addressing modifiable risk factors.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"144 ","pages":"Article 113075"},"PeriodicalIF":3.0,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-22DOI: 10.1016/j.nut.2025.113074
Giulia Andreani , Giovanni Sogari , Adriano Daniele , Miguel I Gómez
Objective
Front-of-package (FOP) labeling schemes could be adopted to provide consumers with timely and credible information and to promote healthy and sustainable food consumption. In addition, when defining healthy and sustainable food behaviors, international authorities agree that reducing meat consumption could be of benefit to both human health and the planet. Given the increasing interest in plant-based meat alternatives (PBMAs) and FOP labels, we investigate in this study how interpretative FOP labels—the Nutri Score (NS) and Eco Score (ES)—impact consumers' sensory expectations and purchase intention of a meat product and its plant-based counterpart.
Method
Using eye-tracking data, we analyzed whether and to what extent attention to these labels affects participants’ behaviors (n = 76). In addition, to explore differences across consumer segments we divided our sample based on the Meat Attachment Questionnaire (MAQ) to classify subjects according to their bond towards meat consumption.
Results
Results showed that attention to the NS or ES did not impact participants with higher MAQ scores (i.e., with a more positive bond toward meat consumption); however, sensory expectations of both the meat and plant-based product were influenced by consumer visual attention for participants with a lower meat attachment level (i.e., with lower MAQ scores). Specifically, we found a positive relationship between the attention paid to the positive ES of the plant-based product and the expectation of liking it (abreviated as "expected liking"), and a positive interaction between the attention paid to the negative NS of the animal product and its expected liking.
Conclusions
We show that favorable sustainable labels can positively shape consumers’ expectations for PBMAs, while negative labels do not undermine expected liking or purchase intention for animal products, and discuss our results to provide insights for future research and implications for both food industries and policymakers.
{"title":"Role of Nutri-Score and Eco-Score in shaping consumers’ sensory expectations and purchase intention: An eye-tracking study on animal- and plant-based foods","authors":"Giulia Andreani , Giovanni Sogari , Adriano Daniele , Miguel I Gómez","doi":"10.1016/j.nut.2025.113074","DOIUrl":"10.1016/j.nut.2025.113074","url":null,"abstract":"<div><h3>Objective</h3><div>Front-of-package (FOP) labeling schemes could be adopted to provide consumers with timely and credible information and to promote healthy and sustainable food consumption. In addition, when defining healthy and sustainable food behaviors, international authorities agree that reducing meat consumption could be of benefit to both human health and the planet. Given the increasing interest in plant-based meat alternatives (PBMAs) and FOP labels, we investigate in this study how interpretative FOP labels—the Nutri Score (NS) and Eco Score (ES)—impact consumers' sensory expectations and purchase intention of a meat product and its plant-based counterpart.</div></div><div><h3>Method</h3><div>Using eye-tracking data, we analyzed whether and to what extent attention to these labels affects participants’ behaviors (n = 76). In addition, to explore differences across consumer segments we divided our sample based on the Meat Attachment Questionnaire (MAQ) to classify subjects according to their bond towards meat consumption.</div></div><div><h3>Results</h3><div>Results showed that attention to the NS or ES did not impact participants with higher MAQ scores (i.e., with a more positive bond toward meat consumption); however, sensory expectations of both the meat and plant-based product were influenced by consumer visual attention for participants with a lower meat attachment level (i.e., with lower MAQ scores). Specifically, we found a positive relationship between the attention paid to the positive ES of the plant-based product and the expectation of liking it (abreviated as \"expected liking\"), and a positive interaction between the attention paid to the negative NS of the animal product and its expected liking.</div></div><div><h3>Conclusions</h3><div>We show that favorable sustainable labels can positively shape consumers’ expectations for PBMAs, while negative labels do not undermine expected liking or purchase intention for animal products, and discuss our results to provide insights for future research and implications for both food industries and policymakers.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"145 ","pages":"Article 113074"},"PeriodicalIF":3.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146065374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study evaluated the relationship between picky eating, mindful eating (ME), orthorexia nervosa (ON) tendency, and diet quality in adults. The secondary aim was to examine whether picky eating mediates the effect of ME on ON tendency.
Methods
A total of 541 adults (mean age 26.6 ± 10.54 y, 50.6% women) participated. Data were collected using a structured questionnaire via face-to-face interviews and convenience sampling. Picky eating (PE) was assessed with the Adult Picky Eating Questionnaire, ME with the ME Inventory (MEI), ON tendency with the Test of ON-17 (TON-17), and diet quality with the Healthy Eating Index-2020. Dietary intake was measured using a 24-h dietary recall.
Results
Among participants, 5.2% had ON, and 41.6% had inadequate diet quality. MEI was positively associated with PE (β = 0.108; P = 0.013) and TON-17 (β = 0.093; P = 0.025). PE was positively associated with TON-17 (β = 0.213; P < 0.001) and negatively associated with Healthy Eating Index-2020 (β = –0.126; P = 0.003). The indirect effect of MEI on TON-17 via PE accounted for 19.8% of the total effect, indicating that PE partially mediated this relationship.
Conclusions
The findings suggest that ME is associated with healthier dietary behavior; however, they may also be related to increased orthorexic tendencies. It also showed that PE mediates between MEI and TON-17. Addressing selective eating behaviors and encouraging balanced, ME in public health strategies may help improve diet quality and reduce eating related problems.
目的：探讨成人挑食、正念饮食（ME）、神经性厌食症（ON）倾向与饮食质量的关系。第二个目的是检验挑食是否介导ME对on倾向的影响。方法：541名成人（平均年龄26.6±10.54岁，女性50.6%）参与研究。数据收集采用面对面访谈和方便抽样的结构化问卷。采用成人挑食问卷（PE）、ME量表（MEI）、ON-17量表（TON-17）和健康饮食指数（Healthy eating Index-2020）评估饮食质量。采用24小时饮食回忆法测量膳食摄入量。结果：在参与者中，5.2%患有ON， 41.6%饮食质量不佳。MEI与PE （β = 0.108; P = 0.013）、TON-17 （β = 0.093; P = 0.025）呈正相关。PE与TON-17呈正相关（β = 0.213, P < 0.001），与健康饮食指数-2020呈负相关（β = -0.126, P = 0.003）。MEI通过PE对TON-17的间接影响占总影响的19.8%，说明PE在其中起到了部分中介作用。结论：研究结果表明ME与更健康的饮食行为有关；然而，它们也可能与增加的正交性倾向有关。PE在MEI和TON-17之间起中介作用。在公共卫生策略中解决选择性饮食行为和鼓励均衡饮食可能有助于改善饮食质量和减少与饮食有关的问题。
{"title":"More mindful, more selective, more disordered? A mediation analysis of picky eating in the link between mindful eating and orthorexia nervosa tendency","authors":"Gizem Özata-Uyar Ph.D. , Serkan Aslan Ph.D. , Merve Arslan M.Sc. , Ayşe Çamli M.Sc. , Osman Bozkurt Ph.D. , Betül Kocaadam-Bozkurt Ph.D.","doi":"10.1016/j.nut.2025.113078","DOIUrl":"10.1016/j.nut.2025.113078","url":null,"abstract":"<div><h3>Aim</h3><div>This study evaluated the relationship between picky eating, mindful eating (ME), orthorexia nervosa (ON) tendency, and diet quality in adults. The secondary aim was to examine whether picky eating mediates the effect of ME on ON tendency.</div></div><div><h3>Methods</h3><div>A total of 541 adults (mean age 26.6 ± 10.54 y, 50.6% women) participated. Data were collected using a structured questionnaire via face-to-face interviews and convenience sampling. Picky eating (PE) was assessed with the Adult Picky Eating Questionnaire, ME with the ME Inventory (MEI), ON tendency with the Test of ON-17 (TON-17), and diet quality with the Healthy Eating Index-2020. Dietary intake was measured using a 24-h dietary recall.</div></div><div><h3>Results</h3><div>Among participants, 5.2% had ON, and 41.6% had inadequate diet quality. MEI was positively associated with PE (<em>β</em> = 0.108; <em>P</em> = 0.013) and TON-17 (<em>β</em> = 0.093; <em>P</em> = 0.025). PE was positively associated with TON-17 (<em>β</em> = 0.213; <em>P</em> < 0.001) and negatively associated with Healthy Eating Index-2020 (<em>β</em> = –0.126; <em>P</em> = 0.003). The indirect effect of MEI on TON-17 via PE accounted for 19.8% of the total effect, indicating that PE partially mediated this relationship.</div></div><div><h3>Conclusions</h3><div>The findings suggest that ME is associated with healthier dietary behavior; however, they may also be related to increased orthorexic tendencies. It also showed that PE mediates between MEI and TON-17. Addressing selective eating behaviors and encouraging balanced, ME in public health strategies may help improve diet quality and reduce eating related problems.</div></div>","PeriodicalId":19482,"journal":{"name":"Nutrition","volume":"143 ","pages":"Article 113078"},"PeriodicalIF":3.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145864054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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