Pub Date : 2003-08-01DOI: 10.11263/JSOTP1982.22.91
Kuniko Tohyama, H. Nakai, Kiyotaka Uenaka, K. Sakata
{"title":"A study on the classification and use of dental drugs","authors":"Kuniko Tohyama, H. Nakai, Kiyotaka Uenaka, K. Sakata","doi":"10.11263/JSOTP1982.22.91","DOIUrl":"https://doi.org/10.11263/JSOTP1982.22.91","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"22 1","pages":"91-99"},"PeriodicalIF":0.0,"publicationDate":"2003-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63818653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-08-01DOI: 10.11263/JSOTP1982.22.61
M. Koshikawa, Kuniaki Suzuki, Y. Sugawara, J. Iida
Bisphosphonates are potent inhibitors of bone resorption. Although the majority of studies have focused on the effects of bisphosphonates on osteoclasts, recent findings suggest that they may also have a direct action on osteoblasts. We studied the effects of long-term exposure to bisphosphonates, YM-529 and etidronate, on cell growth, alkaline phosphatase (ALP) activity and calcification of an osteoblastic cell line, MC3T3-E1 cells. The addition of 10-10M or 10-14M YM-529 increased the ALP activity in comparison with the control at 35 and 25 days after confluence respectively without marked effects on cell growth or appearance. The addition of 10-6M etidronate also increased the activity at 15 days after confluence. The result of calcium staining of the cells and matrices suggested that calcification was promoted at 35 days after confluence by exposure to 10-10 or 10-14M YM-529. These results suggest that proper concentrations of bisphosphonates promote calcification of osteoblastic cells and that bisphosphonates directly act on the function of osteoblasts as well as on osteoclasts.
{"title":"Long-term effects of bisphosphonates on mineralization of osteoblastic cell, MC3T3-E1","authors":"M. Koshikawa, Kuniaki Suzuki, Y. Sugawara, J. Iida","doi":"10.11263/JSOTP1982.22.61","DOIUrl":"https://doi.org/10.11263/JSOTP1982.22.61","url":null,"abstract":"Bisphosphonates are potent inhibitors of bone resorption. Although the majority of studies have focused on the effects of bisphosphonates on osteoclasts, recent findings suggest that they may also have a direct action on osteoblasts. We studied the effects of long-term exposure to bisphosphonates, YM-529 and etidronate, on cell growth, alkaline phosphatase (ALP) activity and calcification of an osteoblastic cell line, MC3T3-E1 cells. The addition of 10-10M or 10-14M YM-529 increased the ALP activity in comparison with the control at 35 and 25 days after confluence respectively without marked effects on cell growth or appearance. The addition of 10-6M etidronate also increased the activity at 15 days after confluence. The result of calcium staining of the cells and matrices suggested that calcification was promoted at 35 days after confluence by exposure to 10-10 or 10-14M YM-529. These results suggest that proper concentrations of bisphosphonates promote calcification of osteoblastic cells and that bisphosphonates directly act on the function of osteoblasts as well as on osteoclasts.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"22 1","pages":"61-68"},"PeriodicalIF":0.0,"publicationDate":"2003-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63818404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Kaneko, J. Sasaki, H. Sakamoto, Yusuke Mori, N. Nakatogawa, I. Arai, T. Oikawa, I. Kawada, Y. Ishida, N. Sato, M. Fujita, T. Yamashita, Yoritoshi Nakajima, E. Amari, K. Nozaka, Teruko Sato, Yuriko Suruga, K. Shiiki, N. Yamane, T. Shirai, D. Watanabe, K. Michi, K. Ohno, Koji Takahashi, Yoh Ohsone, Yasunobu Busujima, K. Ohno, Y. Idaira, Tomohide Takahashi, S. Kawachi, Tohru Nohara, R. Sekiya, Tadashi Yamamoto, A. Kaetsu, J. Machida, Jun Ishii, Ayumi Yoshioka, T. Ishikawa, M. Sugiyama, H. Sunakawa, H. Hiratsuka, Manabu Kishaba, K. Kudoh, R. Sasa, Koya Shiba, K. Sunakawa
{"title":"Clinical evaluation of Cefditoren pivoxil in the treatment of pediatric oral infections","authors":"A. Kaneko, J. Sasaki, H. Sakamoto, Yusuke Mori, N. Nakatogawa, I. Arai, T. Oikawa, I. Kawada, Y. Ishida, N. Sato, M. Fujita, T. Yamashita, Yoritoshi Nakajima, E. Amari, K. Nozaka, Teruko Sato, Yuriko Suruga, K. Shiiki, N. Yamane, T. Shirai, D. Watanabe, K. Michi, K. Ohno, Koji Takahashi, Yoh Ohsone, Yasunobu Busujima, K. Ohno, Y. Idaira, Tomohide Takahashi, S. Kawachi, Tohru Nohara, R. Sekiya, Tadashi Yamamoto, A. Kaetsu, J. Machida, Jun Ishii, Ayumi Yoshioka, T. Ishikawa, M. Sugiyama, H. Sunakawa, H. Hiratsuka, Manabu Kishaba, K. Kudoh, R. Sasa, Koya Shiba, K. Sunakawa","doi":"10.11263/JSOTP1982.22.1","DOIUrl":"https://doi.org/10.11263/JSOTP1982.22.1","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"22 1","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63818335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-04-01DOI: 10.11263/JSOTP1982.22.42
Shigeo Irimajiri, S. Abe, H. Furuya
The objectives of this study are to assess the effectiveness of topical application of capsaicin cream on nerve conduction and to assess it clinically on human patients with facial pain. 1. A 0.075% capsaicin cream was repeatedly applied daily to the upper right lateral maxillary gingiva of rats. They were divided into seven groups consisting of a control group, a five-day treatment group, and one, two, three, four, and five-week treatment groups. Trigeminal sensory evoked potentials were measured in order to provide an objective assessment of its effect on nerve conduction. 2. Fifteen patients, who suffer from facial pain, were instructed to apply the capsaicin cream twice daily to the painful area and were asked about the subjective effect of its application by using a pain score (0-10). At five days it was observed that the capsaisin was already having an effect on suppressing amplitude, and at two weeks the effect was very pronounced. Out of the ten patients suffering from trigeminal neuralgia, six reported a reduction in pain. Out of the five patients suffering from CRPS, four reported a reduction in pain. These results suggested that the topical application of capsaicin cream to oral mucosa causes nerve conduction suppression and the topical application of it to facial pain areas can be used as a means of supplementary pain control for patients suffering from trigeminal neuralgia and CRPS.
{"title":"The Effect of Repeated Topical Application of Capsaicin on Nerve Conduction","authors":"Shigeo Irimajiri, S. Abe, H. Furuya","doi":"10.11263/JSOTP1982.22.42","DOIUrl":"https://doi.org/10.11263/JSOTP1982.22.42","url":null,"abstract":"The objectives of this study are to assess the effectiveness of topical application of capsaicin cream on nerve conduction and to assess it clinically on human patients with facial pain. 1. A 0.075% capsaicin cream was repeatedly applied daily to the upper right lateral maxillary gingiva of rats. They were divided into seven groups consisting of a control group, a five-day treatment group, and one, two, three, four, and five-week treatment groups. Trigeminal sensory evoked potentials were measured in order to provide an objective assessment of its effect on nerve conduction. 2. Fifteen patients, who suffer from facial pain, were instructed to apply the capsaicin cream twice daily to the painful area and were asked about the subjective effect of its application by using a pain score (0-10). At five days it was observed that the capsaisin was already having an effect on suppressing amplitude, and at two weeks the effect was very pronounced. Out of the ten patients suffering from trigeminal neuralgia, six reported a reduction in pain. Out of the five patients suffering from CRPS, four reported a reduction in pain. These results suggested that the topical application of capsaicin cream to oral mucosa causes nerve conduction suppression and the topical application of it to facial pain areas can be used as a means of supplementary pain control for patients suffering from trigeminal neuralgia and CRPS.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"22 1","pages":"42-48"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63818358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-04-01DOI: 10.11263/JSOTP1982.22.18
H. Shoji, Hiroyuki Miyazaki, Fumihiko Yoshino, Yoichi Omori, Shun-suke Takahashi, K. Todoki, Masaichi-chang-il Lee
{"title":"Application of an in vivo ESR imaging system to measure the distribution of nitroxyl spin probe in the maxillofacial region of a living mouse","authors":"H. Shoji, Hiroyuki Miyazaki, Fumihiko Yoshino, Yoichi Omori, Shun-suke Takahashi, K. Todoki, Masaichi-chang-il Lee","doi":"10.11263/JSOTP1982.22.18","DOIUrl":"https://doi.org/10.11263/JSOTP1982.22.18","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"22 1","pages":"18-24"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63818269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-04-01DOI: 10.11263/JSOTP1982.22.25
Kyoko Watanabe, Y. Azuma, M. Daito, K. Ohura
{"title":"Possible interaction of endomorphins with antineoplastic agents in human monocytic leukemia THP-1","authors":"Kyoko Watanabe, Y. Azuma, M. Daito, K. Ohura","doi":"10.11263/JSOTP1982.22.25","DOIUrl":"https://doi.org/10.11263/JSOTP1982.22.25","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"22 1","pages":"25-31"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63818276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-04-01DOI: 10.11263/JSOTP1982.22.36
Masaru Sato, Hitoshi Tanaka, R. Yamaguchi, C. Tokuda
{"title":"Antibacterial activity of a newly isolated isoflavonoid against Gram-positive oral bacteria","authors":"Masaru Sato, Hitoshi Tanaka, R. Yamaguchi, C. Tokuda","doi":"10.11263/JSOTP1982.22.36","DOIUrl":"https://doi.org/10.11263/JSOTP1982.22.36","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"22 1","pages":"36-41"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11263/JSOTP1982.22.36","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63818319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-04-01DOI: 10.11263/JSOTP1982.22.49
Yoshiaki Ninomiya, Yoshiaki Itoh, H. Tohmori, K. Ohta, H. Nishi, S. Inoue, M. Sugiyama, T. Ishikawa
{"title":"Clinicostatistical analyses of methicillin-resistant Staphylococcus aureus (MRSA) detected in inpatients","authors":"Yoshiaki Ninomiya, Yoshiaki Itoh, H. Tohmori, K. Ohta, H. Nishi, S. Inoue, M. Sugiyama, T. Ishikawa","doi":"10.11263/JSOTP1982.22.49","DOIUrl":"https://doi.org/10.11263/JSOTP1982.22.49","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"22 1","pages":"49-54"},"PeriodicalIF":0.0,"publicationDate":"2003-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63818372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2002-08-01DOI: 10.11263/JSOTP1982.21.47
T. Ogawa, H. Kamoi, M. Kanda, Chiri Hirosawa, Yu Ikeda, S. Ishiduka, K. Kamoi
{"title":"Application of antibacterial agents for periodontopathic bacteria","authors":"T. Ogawa, H. Kamoi, M. Kanda, Chiri Hirosawa, Yu Ikeda, S. Ishiduka, K. Kamoi","doi":"10.11263/JSOTP1982.21.47","DOIUrl":"https://doi.org/10.11263/JSOTP1982.21.47","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"21 1","pages":"47-52"},"PeriodicalIF":0.0,"publicationDate":"2002-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63817884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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