Hidehiko Okada, R. Takeuchi, H. Matsumoto, Y. Akimoto, A. Fujii
{"title":"Effect of 18α-Glycyrrhetinic acid on the growth of nifedipine responder cell","authors":"Hidehiko Okada, R. Takeuchi, H. Matsumoto, Y. Akimoto, A. Fujii","doi":"10.11263/JSOTP1982.26.1","DOIUrl":"https://doi.org/10.11263/JSOTP1982.26.1","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"26 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2007-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63820052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Takahiro Miyai, Chiaki Arai, Gaku Tamazawa, J. Nasu, N. Tominaga, Kazuhiko Omata, T. Miyasaka, T. Matsuno, T. Satoh
{"title":"Changes in serum cytokine levels in experimental fractured mice models","authors":"Takahiro Miyai, Chiaki Arai, Gaku Tamazawa, J. Nasu, N. Tominaga, Kazuhiko Omata, T. Miyasaka, T. Matsuno, T. Satoh","doi":"10.11263/JSOTP1982.26.9","DOIUrl":"https://doi.org/10.11263/JSOTP1982.26.9","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"26 1","pages":"9-13"},"PeriodicalIF":0.0,"publicationDate":"2007-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63820246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-04-01DOI: 10.11263/JSOTP1982.26.14
I. Kikuchi, R. Wadachi, T. Yoshioka, H. Suda
The purpose of this study was to investigate the removability of calcium hydroxide dressed in root canals. Three types of calcium hydroxide pastes were used: Calfee paste ðF, Caicipex, ðF and Caicipex II ðF. Five single-rooted human extracted teeth were used. After removing the tooth crowns, the canals were prepared by NiTi files with 0.06 taper using the conventional method, and the roots were sectioned in the bucco-lingual direction so that repositionable root canal models could be obtained. After root canal dressing of the calcium hydroxide pastes, the root canals were irrigated by the following three methods: alternative irrigation with 1.5mL of 3% hydrogen peroxide and 1.5mL of 6 % sodium hypochlorite (NaClO), solely with 3.OmL of NaC1O, or 3.OmL of NaCIO with ultrasonics. Then, the canal model assemblies were dismantled, and the images of the canal wall surfaces were taken with a digital microscope. The ratio of the area occupied by calcium hydroxide pastes to the total canal wall surface area within 3 mm from the root apex was calculated as a percentage for each canal model. Statistical analysis showed that the removability of Calfee paste R was the highest among the three calcium hydroxide pastes (p < 0.05). There were no statistically significant differences among the irrigation methods used (p > 0.05).
{"title":"Removability of three intracanal calcium hydroxide pastes from the root canal","authors":"I. Kikuchi, R. Wadachi, T. Yoshioka, H. Suda","doi":"10.11263/JSOTP1982.26.14","DOIUrl":"https://doi.org/10.11263/JSOTP1982.26.14","url":null,"abstract":"The purpose of this study was to investigate the removability of calcium hydroxide dressed in root canals. Three types of calcium hydroxide pastes were used: Calfee paste ðF, Caicipex, ðF and Caicipex II ðF. Five single-rooted human extracted teeth were used. After removing the tooth crowns, the canals were prepared by NiTi files with 0.06 taper using the conventional method, and the roots were sectioned in the bucco-lingual direction so that repositionable root canal models could be obtained. After root canal dressing of the calcium hydroxide pastes, the root canals were irrigated by the following three methods: alternative irrigation with 1.5mL of 3% hydrogen peroxide and 1.5mL of 6 % sodium hypochlorite (NaClO), solely with 3.OmL of NaC1O, or 3.OmL of NaCIO with ultrasonics. Then, the canal model assemblies were dismantled, and the images of the canal wall surfaces were taken with a digital microscope. The ratio of the area occupied by calcium hydroxide pastes to the total canal wall surface area within 3 mm from the root apex was calculated as a percentage for each canal model. Statistical analysis showed that the removability of Calfee paste R was the highest among the three calcium hydroxide pastes (p < 0.05). There were no statistically significant differences among the irrigation methods used (p > 0.05).","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"26 1","pages":"14-18"},"PeriodicalIF":0.0,"publicationDate":"2007-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-04-01DOI: 10.11263/JSOTP1982.26.19
Morito Suzuki
The effects of tetracyclines in organotypic cocultures using human gingival epithelial cells (NDUSD-1 cells) and human periodontal ligament fibroblasts (Pelt cells) were investigated. The organotypic cocultures were treated with tetracycline (TC) or minocycline (MINO) at 10-300ƒÊM for 1 week and multilayered epithelial cells were examined by hematoxylin-eosin staining and immunohistochemistry. Treatment with TC at 30ƒÊM did not affect multilayer formation of epithelial cells, but the formation was inhibited by treatment with TC at 100ƒÊM or more. Treatment with MINO at 10ƒÊM did not affect the multilayer formation, but the formation was inhibited by treatment with MINO at 30 ƒÊM or more. These values were greater than their MIC90 concentrations for periodontopathic bacteria, including Porphyromonas gingivalis, Prevotella intermedia, and Actinobacillus actinomycetemcomitans. These results suggested that topical administration of TC or MINO to the periodontal pocket at their MIC90 concentration for periodontopathic bacteria would have few adverse effects on the growth of the periodontal ligament.
{"title":"Effect of tetracyclines in organotypic cocultures using human gingival epithelial cells and human periodontal ligament fibroblasts","authors":"Morito Suzuki","doi":"10.11263/JSOTP1982.26.19","DOIUrl":"https://doi.org/10.11263/JSOTP1982.26.19","url":null,"abstract":"The effects of tetracyclines in organotypic cocultures using human gingival epithelial cells (NDUSD-1 cells) and human periodontal ligament fibroblasts (Pelt cells) were investigated. The organotypic cocultures were treated with tetracycline (TC) or minocycline (MINO) at 10-300ƒÊM for 1 week and multilayered epithelial cells were examined by hematoxylin-eosin staining and immunohistochemistry. Treatment with TC at 30ƒÊM did not affect multilayer formation of epithelial cells, but the formation was inhibited by treatment with TC at 100ƒÊM or more. Treatment with MINO at 10ƒÊM did not affect the multilayer formation, but the formation was inhibited by treatment with MINO at 30 ƒÊM or more. These values were greater than their MIC90 concentrations for periodontopathic bacteria, including Porphyromonas gingivalis, Prevotella intermedia, and Actinobacillus actinomycetemcomitans. These results suggested that topical administration of TC or MINO to the periodontal pocket at their MIC90 concentration for periodontopathic bacteria would have few adverse effects on the growth of the periodontal ligament.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"26 1","pages":"19-27"},"PeriodicalIF":0.0,"publicationDate":"2007-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-12-01DOI: 10.11263/JSOTP1982.25.69
Tomohiro Yamada, K. Mishima, Tatsushi Matsumura, T. Sugahara
{"title":"Treatment with perioperative high-dose γ-globulin for a case of mouth floor carcinoma associated with idiopathic thrombocytopenic purpura","authors":"Tomohiro Yamada, K. Mishima, Tatsushi Matsumura, T. Sugahara","doi":"10.11263/JSOTP1982.25.69","DOIUrl":"https://doi.org/10.11263/JSOTP1982.25.69","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"25 1","pages":"69-72"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63820012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-12-01DOI: 10.11263/JSOTP1982.25.73
J. Yamane, Naoto Sato, Hidehiko Okada, M. Hori, Akihiko Gunji, Kosuke Hakozaki, A. Fujii
In order to clarify the correlation between the analgesic and antipyretic effects of aspirin and salicylic acid concentration, a jaw-opening reflex test and pyrogenic test were performed under the presence of aspirin, and the corresponding plasma concentration of salicylic acid was measured using rabbits. The analgesic effect of aspirin determined by jaw-opening reflex was significantly dependent on plasma level. The antipyretic effect of aspirin obtained by the pyrogenic test was also significantly dependent on plasma level. A closer correlation was demonstrated between the integral antipyretic effect and integral plasma level of salicylic acid.
{"title":"Correlation between the analgesic and antipyretic effects of aspirin and salicylic acid concentration in rabbits","authors":"J. Yamane, Naoto Sato, Hidehiko Okada, M. Hori, Akihiko Gunji, Kosuke Hakozaki, A. Fujii","doi":"10.11263/JSOTP1982.25.73","DOIUrl":"https://doi.org/10.11263/JSOTP1982.25.73","url":null,"abstract":"In order to clarify the correlation between the analgesic and antipyretic effects of aspirin and salicylic acid concentration, a jaw-opening reflex test and pyrogenic test were performed under the presence of aspirin, and the corresponding plasma concentration of salicylic acid was measured using rabbits. The analgesic effect of aspirin determined by jaw-opening reflex was significantly dependent on plasma level. The antipyretic effect of aspirin obtained by the pyrogenic test was also significantly dependent on plasma level. A closer correlation was demonstrated between the integral antipyretic effect and integral plasma level of salicylic acid.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"25 1","pages":"73-79"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-12-01DOI: 10.11263/JSOTP1982.25.80
D. Mohri, K. Shimazu, K. Ohura
Rashes due to drugs may be relatively mild such as erosions like canker sores, erythema papula, urticarial rashes, and fixed drug eruption, or they may be quite severe as with Stevens-Johnson syndrome or toxic epidermal necrolysis (Lyell syndrome). Since severe drug eruptions and rashes can affect internal organs in addition to skin and mucosa and can result in permanent disabilities, they must be diagnosed and treated as soon as possible. The vital elements of effective diagnosis are to clearly grasp which types of reactions are the most severe and to quickly identify the reactions which may become serious or threatening. We have found in our own practice that the most serious types of drug erosions and rashes are those that affect the whole body. There is a possibility that a very serious case may develop if an erosion of the oral mucosa spreads out beyond the region of the lip where the mucosa changes to skin or if erythema of the epidermis quickly spreads and red spots grow together over a relatively large area. The treatment is to immediately stop taking all suspect drugs and begin a rigorous course of steroids.
{"title":"Allergic reactions to drugs","authors":"D. Mohri, K. Shimazu, K. Ohura","doi":"10.11263/JSOTP1982.25.80","DOIUrl":"https://doi.org/10.11263/JSOTP1982.25.80","url":null,"abstract":"Rashes due to drugs may be relatively mild such as erosions like canker sores, erythema papula, urticarial rashes, and fixed drug eruption, or they may be quite severe as with Stevens-Johnson syndrome or toxic epidermal necrolysis (Lyell syndrome). Since severe drug eruptions and rashes can affect internal organs in addition to skin and mucosa and can result in permanent disabilities, they must be diagnosed and treated as soon as possible. The vital elements of effective diagnosis are to clearly grasp which types of reactions are the most severe and to quickly identify the reactions which may become serious or threatening. We have found in our own practice that the most serious types of drug erosions and rashes are those that affect the whole body. There is a possibility that a very serious case may develop if an erosion of the oral mucosa spreads out beyond the region of the lip where the mucosa changes to skin or if erythema of the epidermis quickly spreads and red spots grow together over a relatively large area. The treatment is to immediately stop taking all suspect drugs and begin a rigorous course of steroids.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"25 1","pages":"80-87"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-12-01DOI: 10.11263/JSOTP1982.25.61
N. Maeda, T. Ohshima, K. Hojo, N. Taketomo
The term •eprobiotics•f is defined as •eliving microorganisms that exhibit beneficial effects for health based on improvement of balance of indigenous microbiota.•f Several strains of Lactobacillus and Bifidobacterium, and a certain yogurt are included in this definition. Probiotics have been developed for use in the prevention of intestinal infections, and the treatment of antibiotic-associated diarrhea and intestinal malfunction. Recently, the use of probiotics has come to exert a wide range of different effects such as the suppression of Helicobacter pylori, and the prevention of allergic disease. Moreover, evidence for the clinical effectiveness of probiotics has been reported in their use for the prevention and treatment of dental caries and periodontal diseases. For example, the administration of a dairy product containing L. rhamnosus appeared to reduce the risk of dental caries in a randomized, double-blind, placebo-controlled trial. This trial demonstrated reduced levels of dental caries and lower mutans streptococcal counts in probiotics patients after seven months of administration. From the viewpoint of periodontal diseases, it has been suggested that L. salivarius decrease the risk of periodontal disease by eliminating black-pigmented anaerobic rods (BPARs) which have been suspected of playing a role in periodontal disease. Yogurt may suppress the number of mutans streptococci in saliva and improve halitosis. However, there is little available information about the use of probiotics in dentistry. In addition, the role of indigenous Lactobacillus and Bifidobacterium on oral health, the adhesion of probiotics in the human oral cavity, and the mechanisms of probiotics against cariogenic and periodontopathogenic bacteria have not been clarified. In this review, the authors would like to address the possible use and problem of probiotics in dentistry.
{"title":"Do probiotic bacteria improve human oral microbiota","authors":"N. Maeda, T. Ohshima, K. Hojo, N. Taketomo","doi":"10.11263/JSOTP1982.25.61","DOIUrl":"https://doi.org/10.11263/JSOTP1982.25.61","url":null,"abstract":"The term •eprobiotics•f is defined as •eliving microorganisms that exhibit beneficial effects for health based on improvement of balance of indigenous microbiota.•f Several strains of Lactobacillus and Bifidobacterium, and a certain yogurt are included in this definition. Probiotics have been developed for use in the prevention of intestinal infections, and the treatment of antibiotic-associated diarrhea and intestinal malfunction. Recently, the use of probiotics has come to exert a wide range of different effects such as the suppression of Helicobacter pylori, and the prevention of allergic disease. Moreover, evidence for the clinical effectiveness of probiotics has been reported in their use for the prevention and treatment of dental caries and periodontal diseases. For example, the administration of a dairy product containing L. rhamnosus appeared to reduce the risk of dental caries in a randomized, double-blind, placebo-controlled trial. This trial demonstrated reduced levels of dental caries and lower mutans streptococcal counts in probiotics patients after seven months of administration. From the viewpoint of periodontal diseases, it has been suggested that L. salivarius decrease the risk of periodontal disease by eliminating black-pigmented anaerobic rods (BPARs) which have been suspected of playing a role in periodontal disease. Yogurt may suppress the number of mutans streptococci in saliva and improve halitosis. However, there is little available information about the use of probiotics in dentistry. In addition, the role of indigenous Lactobacillus and Bifidobacterium on oral health, the adhesion of probiotics in the human oral cavity, and the mechanisms of probiotics against cariogenic and periodontopathogenic bacteria have not been clarified. In this review, the authors would like to address the possible use and problem of probiotics in dentistry.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"699 1","pages":"61-68"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-08-01DOI: 10.11263/JSOTP1982.25.47
Hiroyuki Nagashima, K. Asada, Hideo Yamamoto, A. Nakayama, Kenichi Yamaguchi, Y. Nakagawa, K. Ishibashi
Actinomycosis is a infectious disease that is characterized by chronic granulomatous and suppurative lesions often caused by Actinomyces israelii. Nowadays, the diagnosis may be difficult because the number of patients with typical symptoms has decreased, and there is a low success rate in culturing the microorganism. In this paper, two cases of osteomyelitis of the mandible caused by infection with Actinomyces are reported. Radiography and CT of these cases revealed bone destruction, and Gram stain of direct smears of pus obtained by extraoral incision showed Gram-positive bacteria with branching filaments.
{"title":"Two cases of mandibular osteomyelitis caused by Actinomyces","authors":"Hiroyuki Nagashima, K. Asada, Hideo Yamamoto, A. Nakayama, Kenichi Yamaguchi, Y. Nakagawa, K. Ishibashi","doi":"10.11263/JSOTP1982.25.47","DOIUrl":"https://doi.org/10.11263/JSOTP1982.25.47","url":null,"abstract":"Actinomycosis is a infectious disease that is characterized by chronic granulomatous and suppurative lesions often caused by Actinomyces israelii. Nowadays, the diagnosis may be difficult because the number of patients with typical symptoms has decreased, and there is a low success rate in culturing the microorganism. In this paper, two cases of osteomyelitis of the mandible caused by infection with Actinomyces are reported. Radiography and CT of these cases revealed bone destruction, and Gram stain of direct smears of pus obtained by extraoral incision showed Gram-positive bacteria with branching filaments.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"25 1","pages":"47-52"},"PeriodicalIF":0.0,"publicationDate":"2006-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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