Pub Date : 2006-08-01DOI: 10.11263/JSOTP1982.25.35
Kiyomi Kurihara, Hiroto Saito, T. Shirota, M. Nagumo, S. Yoshimura
We performed tooth extraction and dental treatment in a patient with multiple drug allergies. The patient was a 29-year-old female with a past medical history of anaphylaxis to local anesthesia; she also had multiple drug allergies to antimicrobial agents and anti-inflammatory agents. Treatments were performed under general anesthesia without local anesthesia or anti-inflammatory agents, and were completed without an immediate anaphylatic reaction, although vomiting, abdominal pain, diarrhea, and hoarse voice were noted after transfer from the operation room. Intraoperative and postoperative blood pressure and pulse rate were stable, and the eosinophil count, histamine, and C3, C4, and IgE complement levels were normal before and after treatment. The result suggested that performing tests using allergy indices before and after treatment and performing treatment in expectation of possible anaphylatic reaction enable safe dental treatment in patients with multiple drug allergies.
{"title":"Dental treatment of a patient with multiple drug allergies under general anesthesia","authors":"Kiyomi Kurihara, Hiroto Saito, T. Shirota, M. Nagumo, S. Yoshimura","doi":"10.11263/JSOTP1982.25.35","DOIUrl":"https://doi.org/10.11263/JSOTP1982.25.35","url":null,"abstract":"We performed tooth extraction and dental treatment in a patient with multiple drug allergies. The patient was a 29-year-old female with a past medical history of anaphylaxis to local anesthesia; she also had multiple drug allergies to antimicrobial agents and anti-inflammatory agents. Treatments were performed under general anesthesia without local anesthesia or anti-inflammatory agents, and were completed without an immediate anaphylatic reaction, although vomiting, abdominal pain, diarrhea, and hoarse voice were noted after transfer from the operation room. Intraoperative and postoperative blood pressure and pulse rate were stable, and the eosinophil count, histamine, and C3, C4, and IgE complement levels were normal before and after treatment. The result suggested that performing tests using allergy indices before and after treatment and performing treatment in expectation of possible anaphylatic reaction enable safe dental treatment in patients with multiple drug allergies.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"25 1","pages":"35-38"},"PeriodicalIF":0.0,"publicationDate":"2006-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Noda, J. Nomura, Y. Matsumura, S. Yanase, M. Sekida, T. Tagawa
A case of severe chronic osteomyelitis of the mandible accompanied with fracture of the mandibular angle and tardive dyskinesia in a 78-year-old male is reported. As treatment with intravenous antibiotics or decortication was not effective, intra-arterial infusion of the antibiotics was performed. This therapy was very effective without complication. In our case, as the patient had had tardive dyskinesia in the past, it was considered that the severe chronic osteomyelitis was closely related to chronic tendoperiotitis caused by muscular overuse.
{"title":"A case of intractable chronic osteomyelitis of the mandible accompanied with pathologic fracture and tardive dyskinesia","authors":"K. Noda, J. Nomura, Y. Matsumura, S. Yanase, M. Sekida, T. Tagawa","doi":"10.11263/JSOTP1982.25.1","DOIUrl":"https://doi.org/10.11263/JSOTP1982.25.1","url":null,"abstract":"A case of severe chronic osteomyelitis of the mandible accompanied with fracture of the mandibular angle and tardive dyskinesia in a 78-year-old male is reported. As treatment with intravenous antibiotics or decortication was not effective, intra-arterial infusion of the antibiotics was performed. This therapy was very effective without complication. In our case, as the patient had had tardive dyskinesia in the past, it was considered that the severe chronic osteomyelitis was closely related to chronic tendoperiotitis caused by muscular overuse.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"25 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2006-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11263/JSOTP1982.25.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kyoko Watanabe, S. Shirasu, Kiyoshi Daito, M. Motoyama, Yoshitomo Ogawa, K. Nakai, K. Ohura, M. Daito
{"title":"Differentiation of the expression of A2a adenosine receptor in macrophage cell lines RAW264","authors":"Kyoko Watanabe, S. Shirasu, Kiyoshi Daito, M. Motoyama, Yoshitomo Ogawa, K. Nakai, K. Ohura, M. Daito","doi":"10.11263/JSOTP1982.25.8","DOIUrl":"https://doi.org/10.11263/JSOTP1982.25.8","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"25 1","pages":"8-16"},"PeriodicalIF":0.0,"publicationDate":"2006-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11263/JSOTP1982.25.8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2006-04-01DOI: 10.11263/JSOTP1982.25.17
Y. Imamura, Pao‐Li Wang, T. Kuno, J. Otogoto, T. Fujii, N. Ota
In the post-genomic era, it is necessary to gain a better understanding of the relationship between genes and oral disease. For example, single nucleotide polymorphisms (SNPs) are the most common form of DNA sequence variation and searching for SNPs covers many genes. To perform genetic testing such as testing for SNPs, DNA samples need to be obtained from patients. In the near future, genetic testing will become widespread as a chair-side procedure in general practice. It would be optimal to use a method that results in minimum bodily injury and that does not cause anxiety to patients. Here, we report a simple method of obtaining lingual mucosal cells with a toothbrush for extraction of DNA samples.
{"title":"A simple method of obtaining lingual mucosal cells with a toothbrush for DNA extraction","authors":"Y. Imamura, Pao‐Li Wang, T. Kuno, J. Otogoto, T. Fujii, N. Ota","doi":"10.11263/JSOTP1982.25.17","DOIUrl":"https://doi.org/10.11263/JSOTP1982.25.17","url":null,"abstract":"In the post-genomic era, it is necessary to gain a better understanding of the relationship between genes and oral disease. For example, single nucleotide polymorphisms (SNPs) are the most common form of DNA sequence variation and searching for SNPs covers many genes. To perform genetic testing such as testing for SNPs, DNA samples need to be obtained from patients. In the near future, genetic testing will become widespread as a chair-side procedure in general practice. It would be optimal to use a method that results in minimum bodily injury and that does not cause anxiety to patients. Here, we report a simple method of obtaining lingual mucosal cells with a toothbrush for extraction of DNA samples.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"25 1","pages":"17-21"},"PeriodicalIF":0.0,"publicationDate":"2006-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-12-01DOI: 10.11263/JSOTP1982.24.95
N. Irie, Katsuhisa Sunada, H. Furuya
In the 1960s, Seeman et al, reported the effects of local anesthetics on the cell membrane, stating that low concentrations of local anesthetics strengthen the erythrocyte membrane and exert an antihemolytic effect as a result, but high concentrations of them cause hemolysis. There have been other reports concerning the interaction between anesthetic potency and hemolysis. In this study, we determined the antihemolytic effect of local anesthetics in human erythrocyte membrane and their correlation to anesthetic potency. Each local anesthetic was added at various concentrations (0-10mM) to isotonic TRIS. LA isotonic TRIS was added to 75ƒÊL of erythrocyte solution. Subsequently, hypotonic TRIS which had the same concentration of local anesthetic as the LA isotonic TRIS, was added. The resultant solution was centrifuged at 12,000g for 5 min. The absorbance of the supernatant to a wavelength of 540nm was measured using a spectrophotometer. The antihemolytic effect of the local anesthetic at each concentration was obtained by the following formula:
{"title":"Study on antihemolitic effect and anesthetic effect of local anesthetics on erythrocyte membrane","authors":"N. Irie, Katsuhisa Sunada, H. Furuya","doi":"10.11263/JSOTP1982.24.95","DOIUrl":"https://doi.org/10.11263/JSOTP1982.24.95","url":null,"abstract":"In the 1960s, Seeman et al, reported the effects of local anesthetics on the cell membrane, stating that low concentrations of local anesthetics strengthen the erythrocyte membrane and exert an antihemolytic effect as a result, but high concentrations of them cause hemolysis. There have been other reports concerning the interaction between anesthetic potency and hemolysis. In this study, we determined the antihemolytic effect of local anesthetics in human erythrocyte membrane and their correlation to anesthetic potency. Each local anesthetic was added at various concentrations (0-10mM) to isotonic TRIS. LA isotonic TRIS was added to 75ƒÊL of erythrocyte solution. Subsequently, hypotonic TRIS which had the same concentration of local anesthetic as the LA isotonic TRIS, was added. The resultant solution was centrifuged at 12,000g for 5 min. The absorbance of the supernatant to a wavelength of 540nm was measured using a spectrophotometer. The antihemolytic effect of the local anesthetic at each concentration was obtained by the following formula:","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"24 1","pages":"95-102"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-12-01DOI: 10.11263/JSOTP1982.24.75
K. Kino, M. Sugisaki, T. Haketa, T. Shibuya, Fumiaki Sato, Y. Amemori, T. Ishikawa, H. Yoshitake, Nahoko Yoshida, Eri Kuruma, H. Tanabe, T. Amagasa
We investigated the influence of administering tandospirone citrate for improving the anxiety level of patients with painful temporomandibular disorders. The participants were recruited from the patients who visited the 1st Department of Oral Surgery in Tokyo Medical and Dental University or the Department of Dentistry in Jikei University School of Medicine from May 1 to December 31, 1999. The tandospirone citrate (30 or 60 mg/day) was administered to the participants for eight weeks. No other therapy was given to the participants except for giving a general instruction to rest the masticatory system. Signs, symptoms and psychological ratings for anxiety, depression and personality traits were recorded at four and eight weeks after the start. The state of anxiety was evaluated by using the Hospital Anxiety and Depression Scale (HADS). Of the total of 58 participants, 37 cases were eligible for analyses. Anxiety score decreased in eight cases although it increased or was unchanged in 29 cases. In comparison between the improved and non-improved group, anxiety (p=0.001), depression (p=0.008) and neuroticism (p=0.007) scores at the baseline in the improved group were significantly higher than in the non-improved group.
{"title":"The effect of a selective 5HT1A receptor agonist (Tandospirone citrate) on the anxiety of patients with painful temporomandibular disorders","authors":"K. Kino, M. Sugisaki, T. Haketa, T. Shibuya, Fumiaki Sato, Y. Amemori, T. Ishikawa, H. Yoshitake, Nahoko Yoshida, Eri Kuruma, H. Tanabe, T. Amagasa","doi":"10.11263/JSOTP1982.24.75","DOIUrl":"https://doi.org/10.11263/JSOTP1982.24.75","url":null,"abstract":"We investigated the influence of administering tandospirone citrate for improving the anxiety level of patients with painful temporomandibular disorders. The participants were recruited from the patients who visited the 1st Department of Oral Surgery in Tokyo Medical and Dental University or the Department of Dentistry in Jikei University School of Medicine from May 1 to December 31, 1999. The tandospirone citrate (30 or 60 mg/day) was administered to the participants for eight weeks. No other therapy was given to the participants except for giving a general instruction to rest the masticatory system. Signs, symptoms and psychological ratings for anxiety, depression and personality traits were recorded at four and eight weeks after the start. The state of anxiety was evaluated by using the Hospital Anxiety and Depression Scale (HADS). Of the total of 58 participants, 37 cases were eligible for analyses. Anxiety score decreased in eight cases although it increased or was unchanged in 29 cases. In comparison between the improved and non-improved group, anxiety (p=0.001), depression (p=0.008) and neuroticism (p=0.007) scores at the baseline in the improved group were significantly higher than in the non-improved group.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"24 1","pages":"75-80"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-12-01DOI: 10.11263/JSOTP1982.24.87
Keiko Suzuki, S. Yamada
{"title":"Exogenous osteopontin fails to restore the impaired cell spreading and migration observed in OPN-null osteoclasts","authors":"Keiko Suzuki, S. Yamada","doi":"10.11263/JSOTP1982.24.87","DOIUrl":"https://doi.org/10.11263/JSOTP1982.24.87","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"24 1","pages":"87-94"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-08-01DOI: 10.11263/JSOTP1982.24.53
M. Takano, Kuniaki Suzuki, Y. Totsuka
{"title":"The effects of potassium homologs and cisplatin on Na, K-ATPase of rabbit brain","authors":"M. Takano, Kuniaki Suzuki, Y. Totsuka","doi":"10.11263/JSOTP1982.24.53","DOIUrl":"https://doi.org/10.11263/JSOTP1982.24.53","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"24 1","pages":"53-63"},"PeriodicalIF":0.0,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-08-01DOI: 10.11263/JSOTP1982.24.64
H. Omata, A. Fujii, Y. Akimoto
{"title":"Cefditoren concentrations in human serum and oral tissues following a single oral administration of cefditoren pivoxil","authors":"H. Omata, A. Fujii, Y. Akimoto","doi":"10.11263/JSOTP1982.24.64","DOIUrl":"https://doi.org/10.11263/JSOTP1982.24.64","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"24 1","pages":"64-68"},"PeriodicalIF":0.0,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2005-08-01DOI: 10.11263/JSOTP1982.24.45
H. Fujisaki, Takashi Oikawa, K. Iwao, T. Fujii, T. Maida, K. Hikita, M. Tamura, Yumiko Konishi, Yoshiteru Kannari, H. Nagayasu, T. Kawakami, Toru Endo
{"title":"Evaluation of the therapeutic effects of Telithromycin in dental infections","authors":"H. Fujisaki, Takashi Oikawa, K. Iwao, T. Fujii, T. Maida, K. Hikita, M. Tamura, Yumiko Konishi, Yoshiteru Kannari, H. Nagayasu, T. Kawakami, Toru Endo","doi":"10.11263/JSOTP1982.24.45","DOIUrl":"https://doi.org/10.11263/JSOTP1982.24.45","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"24 1","pages":"45-52"},"PeriodicalIF":0.0,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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