Pub Date : 2008-04-01DOI: 10.11263/JSOTP1982.27.36
N. Yohkoh, Kayoko Yamamoto, Mieko Takahashi, Michiko Okada, Toru Endo, T. Chiba, H. Endoh, Kenji Kito, E. Suzuki, Mitsuko Morizuka, Noriaki Yoshida, Kuniko Tohyama, S. Ohkubo, Megumi Ohashi, Kiyotaka Uenaka
10東京歯科大学千葉病院薬局 11鶴見大学歯学部附属病院薬局 12神奈川歯科大学附属病院薬剤科 13松本歯科大学病院薬局 14愛知学院大学歯学部附属病院薬剤部 15大阪歯科大学附属病院薬剤科 1 Department of Clinical Pharmacy , Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences (Before : Department of Pharmacy, The Nippon Dental University Niigata Hospital) 2 Department of Pharmacy , Meikai University Hospital, Meikai University School of Dentistry 3 Department of Pharmacy , Iwate Medical University Hospital 4 Department of Pharmacy , Showa University Dental Hospital 5 Department of Pharmacy , Health Sciences University of Hokkaido Hospital 6 Department of Pharmacy , Medical and Dental Clinic, Health Sciences University of Hokkaido 7 Hospital Pharmacy, Ohu University School of Dentistry 8 Department of Pharmacy , Nihon University School of Dentistry Dental Hospital 9 Department of Pharmacy , The Nippon Dental University Hospital 10 Chiba Hospital Pharmacy, Tokyo Dental College 11 Department of Pharmacy , Tsurumi University Dental Hospital 12 Department of Pharmacy , Kanagawa Dental College Hospital 13 Hospital Pharmacy , Matsumoto Dental University 14 Hospital Pharmacy , Aichigakuin University Dental Hospital 15 Department of Pharmacy , Osaka Dental University Hospital
{"title":"Survey on trends in the use of antibiotics in dental practice among 17 private dental university hospitals in Japan","authors":"N. Yohkoh, Kayoko Yamamoto, Mieko Takahashi, Michiko Okada, Toru Endo, T. Chiba, H. Endoh, Kenji Kito, E. Suzuki, Mitsuko Morizuka, Noriaki Yoshida, Kuniko Tohyama, S. Ohkubo, Megumi Ohashi, Kiyotaka Uenaka","doi":"10.11263/JSOTP1982.27.36","DOIUrl":"https://doi.org/10.11263/JSOTP1982.27.36","url":null,"abstract":"10東京歯科大学千葉病院薬局 11鶴見大学歯学部附属病院薬局 12神奈川歯科大学附属病院薬剤科 13松本歯科大学病院薬局 14愛知学院大学歯学部附属病院薬剤部 15大阪歯科大学附属病院薬剤科 1 Department of Clinical Pharmacy , Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences (Before : Department of Pharmacy, The Nippon Dental University Niigata Hospital) 2 Department of Pharmacy , Meikai University Hospital, Meikai University School of Dentistry 3 Department of Pharmacy , Iwate Medical University Hospital 4 Department of Pharmacy , Showa University Dental Hospital 5 Department of Pharmacy , Health Sciences University of Hokkaido Hospital 6 Department of Pharmacy , Medical and Dental Clinic, Health Sciences University of Hokkaido 7 Hospital Pharmacy, Ohu University School of Dentistry 8 Department of Pharmacy , Nihon University School of Dentistry Dental Hospital 9 Department of Pharmacy , The Nippon Dental University Hospital 10 Chiba Hospital Pharmacy, Tokyo Dental College 11 Department of Pharmacy , Tsurumi University Dental Hospital 12 Department of Pharmacy , Kanagawa Dental College Hospital 13 Hospital Pharmacy , Matsumoto Dental University 14 Hospital Pharmacy , Aichigakuin University Dental Hospital 15 Department of Pharmacy , Osaka Dental University Hospital","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"127 1","pages":"36-44"},"PeriodicalIF":0.0,"publicationDate":"2008-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63820308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2008-04-01DOI: 10.11263/JSOTP1982.27.45
Akihiko Gunji, H. Matsumoto
{"title":"Relationship between cAMP level and intracellular Ca2+ response elicited by histamine in human gingival fibroblasts","authors":"Akihiko Gunji, H. Matsumoto","doi":"10.11263/JSOTP1982.27.45","DOIUrl":"https://doi.org/10.11263/JSOTP1982.27.45","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"27 1","pages":"45-52"},"PeriodicalIF":0.0,"publicationDate":"2008-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63821014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-12-01DOI: 10.11263/JSOTP1982.26.80
N. Arai, T. Kojima, Tetsuo Suzuki, T. Amagasa
Cronkhite-Canada syndrome (CCS) is a rare, sporadically occurring and non-familial syndrome. We report a case of CCS with hypogeusia. A 68-year-old male was suffering from diarrhea and anorexia. Endoscopic examination revealed gastrointestinal polyposis. He visited our clinic complaining of taste disturbance. Together with hyperpigmentation of skin, nail dystrophy and smooth tongue, he was diagnosed as CCS. The patient was treated with predonine and then zinc sulfate. Two months later, taste score was greatly improved. The gastrointestinal polyps were found to have disappeared at 4 months and the blood zinc concentration to have recovered at 6 months after treatment. The patients progress remains good about 5 years later.
{"title":"A case of Cronkhite-Canada syndrome with hypogeusia","authors":"N. Arai, T. Kojima, Tetsuo Suzuki, T. Amagasa","doi":"10.11263/JSOTP1982.26.80","DOIUrl":"https://doi.org/10.11263/JSOTP1982.26.80","url":null,"abstract":"Cronkhite-Canada syndrome (CCS) is a rare, sporadically occurring and non-familial syndrome. We report a case of CCS with hypogeusia. A 68-year-old male was suffering from diarrhea and anorexia. Endoscopic examination revealed gastrointestinal polyposis. He visited our clinic complaining of taste disturbance. Together with hyperpigmentation of skin, nail dystrophy and smooth tongue, he was diagnosed as CCS. The patient was treated with predonine and then zinc sulfate. Two months later, taste score was greatly improved. The gastrointestinal polyps were found to have disappeared at 4 months and the blood zinc concentration to have recovered at 6 months after treatment. The patients progress remains good about 5 years later.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"26 1","pages":"80-85"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63820186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-12-01DOI: 10.11263/JSOTP1982.26.76
M. Takeuchi, H. Naito, K. Shiiki
TS-1 is an oral anticancer agent which has significant therapeutic action against head and neck cancer. However, myelosuppression, liver and digestive tract disorders are known as adverse reactions. We present a case of duodenal ulcer which was considered to be induced by TS-1. A 76-year-old female, who was diagnosed as having lower gingival cancer, underwent left neck dissection, hemimandibular resection and reconstruction with rectal abdominal myocutaneous free flap. She was given a daily dose of 100 mg of TS-1 as adjuvant chemotherapy after the surgical treatment. She complained of dull abdominal pain 12 days after treatment with TS-1. Because the symptom became worse, she was hospitalized urgently. Endoscopic examination showed multiple duodenal ulcers which were well defined, with even deepness. We immediately stopped TS-1 administration. These ulcers subsided after the withdrawal of TS-1 with fasting and fluid therapy for several days. In case of long-term administration of TS-1 for advanced / recurrent head and neck cancer, it must be considered that acute ulcer of the digestive tract may be induced as an adverse reaction.
{"title":"Duodenal ulcer induced by TS-1 in adjuvant chemotherapy for head and neck cancer: A case report","authors":"M. Takeuchi, H. Naito, K. Shiiki","doi":"10.11263/JSOTP1982.26.76","DOIUrl":"https://doi.org/10.11263/JSOTP1982.26.76","url":null,"abstract":"TS-1 is an oral anticancer agent which has significant therapeutic action against head and neck cancer. However, myelosuppression, liver and digestive tract disorders are known as adverse reactions. We present a case of duodenal ulcer which was considered to be induced by TS-1. A 76-year-old female, who was diagnosed as having lower gingival cancer, underwent left neck dissection, hemimandibular resection and reconstruction with rectal abdominal myocutaneous free flap. She was given a daily dose of 100 mg of TS-1 as adjuvant chemotherapy after the surgical treatment. She complained of dull abdominal pain 12 days after treatment with TS-1. Because the symptom became worse, she was hospitalized urgently. Endoscopic examination showed multiple duodenal ulcers which were well defined, with even deepness. We immediately stopped TS-1 administration. These ulcers subsided after the withdrawal of TS-1 with fasting and fluid therapy for several days. In case of long-term administration of TS-1 for advanced / recurrent head and neck cancer, it must be considered that acute ulcer of the digestive tract may be induced as an adverse reaction.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"26 1","pages":"76-79"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63820126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-12-01DOI: 10.11263/JSOTP1982.26.73
Y. Masuda, M. Shinohara, K. Ohura
We investigated the antimicrobial susceptibilities of Enterobacter gergoviae using 12 strains that were isolated from a tooth with periapical lesion. Antibacterial activity was estimated using minimum inhibitory concentrations. Antimicrobial agents examined were gentamicin (GM), cefalotin (CET), sulbactam ampicillin (SBT/ABPC), ampicillin (ABPC), ofloxacin (OFLX), and erythromycin (EM). GM, OFLX and EM showed high sensitivity in comparison with ATCC 33028.
{"title":"Sensitivity of clinically isolated Enterobacter gergoviae to various antibacterial agents","authors":"Y. Masuda, M. Shinohara, K. Ohura","doi":"10.11263/JSOTP1982.26.73","DOIUrl":"https://doi.org/10.11263/JSOTP1982.26.73","url":null,"abstract":"We investigated the antimicrobial susceptibilities of Enterobacter gergoviae using 12 strains that were isolated from a tooth with periapical lesion. Antibacterial activity was estimated using minimum inhibitory concentrations. Antimicrobial agents examined were gentamicin (GM), cefalotin (CET), sulbactam ampicillin (SBT/ABPC), ampicillin (ABPC), ofloxacin (OFLX), and erythromycin (EM). GM, OFLX and EM showed high sensitivity in comparison with ATCC 33028.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"26 1","pages":"73-75"},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63820554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-08-01DOI: 10.11263/JSOTP1982.26.55
Y. Morimoto, M. Konishi, Y. Imai, K. Inagake, S. Fukutsuji, T. Kirita
{"title":"Resistant recurrent aphthous stomatitis in an AIDS patient","authors":"Y. Morimoto, M. Konishi, Y. Imai, K. Inagake, S. Fukutsuji, T. Kirita","doi":"10.11263/JSOTP1982.26.55","DOIUrl":"https://doi.org/10.11263/JSOTP1982.26.55","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"26 1","pages":"55-60"},"PeriodicalIF":0.0,"publicationDate":"2007-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63820502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-08-01DOI: 10.11263/JSOTP1982.26.61
K. Asada, Hiroyuki Usui, A. Nakayama, Hiroyuki Nagashima, K. Ishibashi
{"title":"A case of Garrè's osteomyelitis of the mandible associated with perimandibular abscess","authors":"K. Asada, Hiroyuki Usui, A. Nakayama, Hiroyuki Nagashima, K. Ishibashi","doi":"10.11263/JSOTP1982.26.61","DOIUrl":"https://doi.org/10.11263/JSOTP1982.26.61","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"26 1","pages":"61-67"},"PeriodicalIF":0.0,"publicationDate":"2007-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11263/JSOTP1982.26.61","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63820521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-08-01DOI: 10.11263/JSOTP1982.26.37
Noriaki Yamashita, T. Matsuno, Takahiro Miyai, Chiaki Arai, M. Adachi, T. Satoh
In the perioperative period, perioperative infections are the most commonly observed postsurgical complication. For this reason, potent antibacterial drugs with wide spectrums are administered at huge doses for long periods of time, which has resulted in the appearance of microbes with multiple drug resistance. Therefore, we believe an appropriate administration period for preventive antibacterial drugs should be evidence-based. In the present study, we investigated the administration periods for preventive antibacterial drugs as perioperative management using the changes over time of cytokines as preturgical and postsurgical inflammatory signs in orthognathic surgery (sagittal splitting ramus osteotomy). The cytokines IL-lei, IL-6, IFNy, IL-10, and IL-15 were measured over time and their levels were compared with biological markers of inflammation, such as CRP, which accompany surgical invasion. The level of the inflammatory cytokine IL-6 increased beginning immediately after the surgery and peaked one day after surgery, following which it decreased . IL-15 reached its peak value 2 days after surgery and then it declined. Since IL-6 started to increase immediately after the surgery compared to the WBC count and CRP, it may be possible to use IL-6 early on to assess the degree of invasiveness, while IL-15 is an important cytokine for understanding the biological responses after surgery. Thus, measuring IL-6 and IL-15 is clinically useful for assessing the degree of invasiveness and postsurgical biological response, and it is believed that an administration period for preventive antibacterial drugs of 2 days or less after surgery is appropriate.
{"title":"Study on diachronic changes of inflammatory cytokines and perioperative management in orthognathic surgery","authors":"Noriaki Yamashita, T. Matsuno, Takahiro Miyai, Chiaki Arai, M. Adachi, T. Satoh","doi":"10.11263/JSOTP1982.26.37","DOIUrl":"https://doi.org/10.11263/JSOTP1982.26.37","url":null,"abstract":"In the perioperative period, perioperative infections are the most commonly observed postsurgical complication. For this reason, potent antibacterial drugs with wide spectrums are administered at huge doses for long periods of time, which has resulted in the appearance of microbes with multiple drug resistance. Therefore, we believe an appropriate administration period for preventive antibacterial drugs should be evidence-based. In the present study, we investigated the administration periods for preventive antibacterial drugs as perioperative management using the changes over time of cytokines as preturgical and postsurgical inflammatory signs in orthognathic surgery (sagittal splitting ramus osteotomy). The cytokines IL-lei, IL-6, IFNy, IL-10, and IL-15 were measured over time and their levels were compared with biological markers of inflammation, such as CRP, which accompany surgical invasion. The level of the inflammatory cytokine IL-6 increased beginning immediately after the surgery and peaked one day after surgery, following which it decreased . IL-15 reached its peak value 2 days after surgery and then it declined. Since IL-6 started to increase immediately after the surgery compared to the WBC count and CRP, it may be possible to use IL-6 early on to assess the degree of invasiveness, while IL-15 is an important cytokine for understanding the biological responses after surgery. Thus, measuring IL-6 and IL-15 is clinically useful for assessing the degree of invasiveness and postsurgical biological response, and it is believed that an administration period for preventive antibacterial drugs of 2 days or less after surgery is appropriate.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"26 1","pages":"37-43"},"PeriodicalIF":0.0,"publicationDate":"2007-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63820323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-08-01DOI: 10.11263/JSOTP1982.26.44
K. Kakudo, K. Ishibashi, K. Ohura, S. Okabe, K. Kino, K. Kurita, T. Shibata, M. Sugisaki, K. Murakami, H. Kubo
Although the importance of pharmacological intervention as early treatment for temporomandibular joint disorders has recently increased, there have been few reports on close investigation of the efficacy, and no efficacy evaluation criteria have been established. The Japanese Society of Oral Therapeutics and Pharmacology established a committee for the standardization of NSAIDs efficacy evaluation for temporomandibular joint pain, and prepared new NSAIDs efficacy evalu-
{"title":"The standardization of evaluation of NSAIDs efficacy in temporomandibular joint disorders","authors":"K. Kakudo, K. Ishibashi, K. Ohura, S. Okabe, K. Kino, K. Kurita, T. Shibata, M. Sugisaki, K. Murakami, H. Kubo","doi":"10.11263/JSOTP1982.26.44","DOIUrl":"https://doi.org/10.11263/JSOTP1982.26.44","url":null,"abstract":"Although the importance of pharmacological intervention as early treatment for temporomandibular joint disorders has recently increased, there have been few reports on close investigation of the efficacy, and no efficacy evaluation criteria have been established. The Japanese Society of Oral Therapeutics and Pharmacology established a committee for the standardization of NSAIDs efficacy evaluation for temporomandibular joint pain, and prepared new NSAIDs efficacy evalu-","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"26 1","pages":"44-54"},"PeriodicalIF":0.0,"publicationDate":"2007-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63820399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-04-01DOI: 10.11263/JSOTP1982.26.28
H. Kurabayashi, M. Sasaki, K. Izawa, Mitsunobu Oturu, A. Kaneko
{"title":"A case of postoperative MRSA wound infection and enteritis of mandibular bone ameloblastoma successfully treated with linezolid","authors":"H. Kurabayashi, M. Sasaki, K. Izawa, Mitsunobu Oturu, A. Kaneko","doi":"10.11263/JSOTP1982.26.28","DOIUrl":"https://doi.org/10.11263/JSOTP1982.26.28","url":null,"abstract":"","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"26 1","pages":"28-31"},"PeriodicalIF":0.0,"publicationDate":"2007-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63819888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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