The method emphasizes identification and validation of potential Genotoxic impurity in pharmaceutical drug substances of Ezetimibe by Reverse Phase High-Performance Liquid Chromatography (HPLC). The impurity was separated by using the Zorbax Rx Octylsilane (C8) HPLC column with 250 cm length and internal diameter of 4.6 mm with pore size 5 μm. The partition of impurity was operated at a significant pH 3.0 was maintained by buffer of 10% potassium dihydrogen phosphate and Acetonitrile with 80:20 ratio and the mobile phase is Acetonitrile with a gradient inflow of 1.5 mL/min. The UV absorption maximum were observed at 258 nm. The proposed approach shows the results of linear boundaries in between 0.16 μg/g to 7.5 μg/g with correlation coefficient is lower than 0.999. The method was further evident by accuracy results are in the region of 98.82% to101.04% for Genotoxic impurity of (5R, 6S)-1-(4-fluorophenyl)-5-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-3-(2-hydroxy-1-phenylethyl)-6-(4hydroxyphenyl)di-hydropyrimidine-2,4(1H,3H)-dione. The approach was shown acceptable results as per International Council of Harmonisation (ICH) guidelines and the method was operated even at lower concentrations.
{"title":"Identification and Validation of Genotoxic Impurity in Ezetimibe by Reverse Phase High-Performance Liquid Chromatography","authors":"B. Veeraswami, R. RamaRao","doi":"10.13005/ojc/390410","DOIUrl":"https://doi.org/10.13005/ojc/390410","url":null,"abstract":"The method emphasizes identification and validation of potential Genotoxic impurity in pharmaceutical drug substances of Ezetimibe by Reverse Phase High-Performance Liquid Chromatography (HPLC). The impurity was separated by using the Zorbax Rx Octylsilane (C8) HPLC column with 250 cm length and internal diameter of 4.6 mm with pore size 5 μm. The partition of impurity was operated at a significant pH 3.0 was maintained by buffer of 10% potassium dihydrogen phosphate and Acetonitrile with 80:20 ratio and the mobile phase is Acetonitrile with a gradient inflow of 1.5 mL/min. The UV absorption maximum were observed at 258 nm. The proposed approach shows the results of linear boundaries in between 0.16 μg/g to 7.5 μg/g with correlation coefficient is lower than 0.999. The method was further evident by accuracy results are in the region of 98.82% to101.04% for Genotoxic impurity of (5R, 6S)-1-(4-fluorophenyl)-5-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-3-(2-hydroxy-1-phenylethyl)-6-(4hydroxyphenyl)di-hydropyrimidine-2,4(1H,3H)-dione. The approach was shown acceptable results as per International Council of Harmonisation (ICH) guidelines and the method was operated even at lower concentrations.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43045698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Weiam A. Hussein, Mohammed Khaled Bin Break, A. Alafnan, Bader I Huwaimel, W. M. A. Khojali, N. Khalifa, Farhan Alshammari, Tahani S. Albalawi, Ghaliah Alshammary, Zhawah F. Alshammary, Haya O. Almutairi, Reem M. Alrasheedi, Shahad Fayad
In medicinal chemistry, the link between structure and activity is essential. We are seeking to relate chemical structure and reactivity to medicinal properties, which has gained popularity recently. In this study, scaffolds from three antioxidants were changed to new derivatives to show that their biological effects as antioxidants would change. We also reviewed the anticancer effects of these medications (based on the SRB test) to find other biological effects that may be related to their chemical structural modifications. Moreover, SWISS ADME software was used to determine further ADME characteristics. Compound 2C had the highest cytotoxicity (1.2 μM) against lung cancer cell lines, whereas 1C had good cytotoxicity (87.66 μM). Compound 2C also demonstrated excellent cytotoxicity against the other three cell lines with IC50 values of 5.049, 6.26, and 9.71 μM, respectively. After its antioxidant structure was tweaked, 1C might be a critical molecule for building a novel treatment for lung cancer.
{"title":"Correlation Between Structure and New Anti-cancer Activity of Some Antioxidants Following Chemical Structure Modification Does The Evidence Support This Correlation","authors":"Weiam A. Hussein, Mohammed Khaled Bin Break, A. Alafnan, Bader I Huwaimel, W. M. A. Khojali, N. Khalifa, Farhan Alshammari, Tahani S. Albalawi, Ghaliah Alshammary, Zhawah F. Alshammary, Haya O. Almutairi, Reem M. Alrasheedi, Shahad Fayad","doi":"10.13005/ojc/390401","DOIUrl":"https://doi.org/10.13005/ojc/390401","url":null,"abstract":"In medicinal chemistry, the link between structure and activity is essential. We are seeking to relate chemical structure and reactivity to medicinal properties, which has gained popularity recently. In this study, scaffolds from three antioxidants were changed to new derivatives to show that their biological effects as antioxidants would change. We also reviewed the anticancer effects of these medications (based on the SRB test) to find other biological effects that may be related to their chemical structural modifications. Moreover, SWISS ADME software was used to determine further ADME characteristics. Compound 2C had the highest cytotoxicity (1.2 μM) against lung cancer cell lines, whereas 1C had good cytotoxicity (87.66 μM). Compound 2C also demonstrated excellent cytotoxicity against the other three cell lines with IC50 values of 5.049, 6.26, and 9.71 μM, respectively. After its antioxidant structure was tweaked, 1C might be a critical molecule for building a novel treatment for lung cancer.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48041674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The oxidation of Mandelic Acids to the corresponding oxoacids with ethylenediammonium dichromate (EDDC) in aqueous acetic acid has been studied. The reaction is first order with respect to [EDDC] and less than two order observed for Mandelic acids and [H+]. The oxidation of α-deuteriomandelic acid shows the presence of a primary kinetic isotope effect (kH/kD = 6.01 at 298K). The reaction has been found to be catalyzed by [H+] ions. The various thermodynamic parameters for the oxidation have been reported and discussed along with the validity of the isokinetic relationship. With a negative reaction constant (ρ), the reaction displayed a strong correlation with the Hammett σ values. All of the chosen Mandelic acids are oxidised by the same process, according to the Exner plot.
{"title":"The Oxidative Transformation of Substituted Mandelic acids by Ethylenediammonium Dichromate in AcOH-H2 O medium: (A Kinetic Study)","authors":"Priyanka Kharetiya, D. Panday","doi":"10.13005/ojc/390427","DOIUrl":"https://doi.org/10.13005/ojc/390427","url":null,"abstract":"The oxidation of Mandelic Acids to the corresponding oxoacids with ethylenediammonium dichromate (EDDC) in aqueous acetic acid has been studied. The reaction is first order with respect to [EDDC] and less than two order observed for Mandelic acids and [H+]. The oxidation of α-deuteriomandelic acid shows the presence of a primary kinetic isotope effect (kH/kD = 6.01 at 298K). The reaction has been found to be catalyzed by [H+] ions. The various thermodynamic parameters for the oxidation have been reported and discussed along with the validity of the isokinetic relationship. With a negative reaction constant (ρ), the reaction displayed a strong correlation with the Hammett σ values. All of the chosen Mandelic acids are oxidised by the same process, according to the Exner plot.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42906348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Poornima, A. Sankar, S. Rameshkumar, M. Periasamy
Using the EIS method (Electrochemical Impedance Spectroscopy), the interaction of the BLM (lipid bilayer membrane) system with Ofloxacin in NaCl bath solutions was studied. The BLM system shows electrical properties and stability, which mainly depend on the concentration of the sodium chloride bath solution. The stability of the BLM system increased due to the increase in the concentration of NaCl. On the surface of BLM, a fixing impact has been created due to the cations. The Ofloxacin atoms get divided into the BLM stage and display the fluidization impact. The resistance of the membrane decreases with the concentration of Ofloxacin. To identify Ofloxacin in the arrangement, an impedimetric sensor was created. The level of Ofloxacin detected mainly depends on the sodium chloride concentration present in the bath solution.
{"title":"Impedance Analysis on Interaction Between Ofloxacin and Supported Bilayer Lipid Membrane(BLM)","authors":"K. Poornima, A. Sankar, S. Rameshkumar, M. Periasamy","doi":"10.13005/ojc/390426","DOIUrl":"https://doi.org/10.13005/ojc/390426","url":null,"abstract":"Using the EIS method (Electrochemical Impedance Spectroscopy), the interaction of the BLM (lipid bilayer membrane) system with Ofloxacin in NaCl bath solutions was studied. The BLM system shows electrical properties and stability, which mainly depend on the concentration of the sodium chloride bath solution. The stability of the BLM system increased due to the increase in the concentration of NaCl. On the surface of BLM, a fixing impact has been created due to the cations. The Ofloxacin atoms get divided into the BLM stage and display the fluidization impact. The resistance of the membrane decreases with the concentration of Ofloxacin. To identify Ofloxacin in the arrangement, an impedimetric sensor was created. The level of Ofloxacin detected mainly depends on the sodium chloride concentration present in the bath solution.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46013037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Shaaban, A. A. Al-karmalawy, Abdulrahman G. Alhamzani, M. Abou-Krisha, Mahmoud A. Al-Qudah, T. Yousef
Herein, we report the synthesis of novel thiazo-isoindolinedione derivatives in excellent yields (up to 92%) from the reaction of thiazolidinedione and isoindoline-dione. The structures of the novel compounds were elucidated by 1H-, 13C-NMR, and MS analyses. Furthermore, molecular docking analysis was performed to study the potential inhibition of the SARS-CoV-2 main protease (Mpro) by the new thiazo-isoindolinediones. The present study revealed that the new thiazo-isoindolinediones could inhibit the Mpro and represent a promising platform for the experimental development of new antiviral drugs based on thiazo-isoindolinedione scaffolds.
{"title":"Synthesis and Molecular Docking Analysis of New Thiazo-isoindolinedione Hybrids as Potential Inhibitors of the SARS-CoV-2 Main Protease","authors":"S. Shaaban, A. A. Al-karmalawy, Abdulrahman G. Alhamzani, M. Abou-Krisha, Mahmoud A. Al-Qudah, T. Yousef","doi":"10.13005/ojc/390412","DOIUrl":"https://doi.org/10.13005/ojc/390412","url":null,"abstract":"Herein, we report the synthesis of novel thiazo-isoindolinedione derivatives in excellent yields (up to 92%) from the reaction of thiazolidinedione and isoindoline-dione. The structures of the novel compounds were elucidated by 1H-, 13C-NMR, and MS analyses. Furthermore, molecular docking analysis was performed to study the potential inhibition of the SARS-CoV-2 main protease (Mpro) by the new thiazo-isoindolinediones. The present study revealed that the new thiazo-isoindolinediones could inhibit the Mpro and represent a promising platform for the experimental development of new antiviral drugs based on thiazo-isoindolinedione scaffolds.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43326081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amen Kpetemey, S. Tchegueni, M. B. Bodjona, K. A. Degbe, K. Kili, G. Tchangbedji, R. Idouhli
Recovering spent lithium-ion batteries can help protect the environment and generate added value. The aim of this work is to characterize the various parts of these spent lithium-ion batteries for subsequent recovery of the precious metal elements. The batteries were collected, electrically discharged and dismantled, and the various components quantified. The cathode powder obtained after basic leaching was characterized by ICP and XRD. The batteries consist of steel (21.10%) and plastic shells, the anode (24.40%), the electrolyte-soaked separator and the cathode (35.86%). The anode consists of graphite deposited on a copper foil representing 15.15% of its weight, and the cathode of aluminum foil (3.93%) and lithium cobalt oxide. Physico-chemical characterization of the cathode powder yielded CoO (65.30%), Li2O (5.39%), MnO (15.78%) and NiO (2.17%). At the end of this study, we note the presence of precious metals, on which our subsequent recovery work will focus.
{"title":"Quantification of Recoverable Components of Spent Lithium-Ion Batteries","authors":"Amen Kpetemey, S. Tchegueni, M. B. Bodjona, K. A. Degbe, K. Kili, G. Tchangbedji, R. Idouhli","doi":"10.13005/ojc/390414","DOIUrl":"https://doi.org/10.13005/ojc/390414","url":null,"abstract":"Recovering spent lithium-ion batteries can help protect the environment and generate added value. The aim of this work is to characterize the various parts of these spent lithium-ion batteries for subsequent recovery of the precious metal elements. The batteries were collected, electrically discharged and dismantled, and the various components quantified. The cathode powder obtained after basic leaching was characterized by ICP and XRD. The batteries consist of steel (21.10%) and plastic shells, the anode (24.40%), the electrolyte-soaked separator and the cathode (35.86%). The anode consists of graphite deposited on a copper foil representing 15.15% of its weight, and the cathode of aluminum foil (3.93%) and lithium cobalt oxide. Physico-chemical characterization of the cathode powder yielded CoO (65.30%), Li2O (5.39%), MnO (15.78%) and NiO (2.17%). At the end of this study, we note the presence of precious metals, on which our subsequent recovery work will focus.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66473165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RP-HPLC method developed is a simple, precise and functional technique for the calculation of amount of Quetiapine fumarate from marketed tablets and bulk form. The RP-HPLC analysis was carried out on Hyper chrome ODS-BP 5µm column (4.6mm × 200mm) using a mobile phase 0.1% Orthophoshoric acid and Acetonitrile (80:20v/v) with pH 5.5. Quetiapine fumarate quantified by using UV detector at 210nm. The retention time of the Quetiapine fumarate was found to be 2.6 min. The linearity of the drug concentration ranges from 20-400µg/ml. The detection and quantification limits were intended at 3.70µg/ml and 12.35µg/ml. The precision, accuracy, specificity, robustness and degradation studies were validated.
{"title":"Analytical Method Development and Validation of Quetiapine Fumarate in API and Dosage form by Using RP–HPLC","authors":"Siva Sanker Reddy Lingareddygari*, Nageswara Rao Ravikrindhi","doi":"10.13005/ojc/390430","DOIUrl":"https://doi.org/10.13005/ojc/390430","url":null,"abstract":"RP-HPLC method developed is a simple, precise and functional technique for the calculation of amount of Quetiapine fumarate from marketed tablets and bulk form. The RP-HPLC analysis was carried out on Hyper chrome ODS-BP 5µm column (4.6mm × 200mm) using a mobile phase 0.1% Orthophoshoric acid and Acetonitrile (80:20v/v) with pH 5.5. Quetiapine fumarate quantified by using UV detector at 210nm. The retention time of the Quetiapine fumarate was found to be 2.6 min. The linearity of the drug concentration ranges from 20-400µg/ml. The detection and quantification limits were intended at 3.70µg/ml and 12.35µg/ml. The precision, accuracy, specificity, robustness and degradation studies were validated.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136143580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Several novel 1,3,4-oxadiazole compounds were synthesized for this investigation. NMR and IR spectrum analysis as well as carbon, hydrogen, and nitrogen studies were used to characterize these novel synthesized compounds. Antibacterial and antifungal tests were conducted on all of the newly synthesized compounds. Staphylococcus aureus and Bacillus subtilis, both Gram +ve bacteria, and Escherichia coli and Pseudomonas aureginosa, both Gram -ve bacteria, were utilised in antibacterial studies. Aspergillus niger and Candida albicans were used to test the efficacy of antifungal treatments. Ciprofloxacin and fluconazole were utilized as reference medications in antibacterial and antifungal research, respectively. The inhibitory effects ranged from mild to strong across all of the substances. The results of the screenings showed that several of the compounds had stronger antibacterial and antifungal properties than the standard medicines.
{"title":"Synthesis, Characterization and Antimicrobial Evaluation of Amino acid Derivatives of 1,3,4-Oxadiazole","authors":"Yudhishthir Vaishnav, Sangeeta Rajpurohit, Kamalkant Vyas","doi":"10.13005/ojc/390422","DOIUrl":"https://doi.org/10.13005/ojc/390422","url":null,"abstract":"Several novel 1,3,4-oxadiazole compounds were synthesized for this investigation. NMR and IR spectrum analysis as well as carbon, hydrogen, and nitrogen studies were used to characterize these novel synthesized compounds. Antibacterial and antifungal tests were conducted on all of the newly synthesized compounds. Staphylococcus aureus and Bacillus subtilis, both Gram +ve bacteria, and Escherichia coli and Pseudomonas aureginosa, both Gram -ve bacteria, were utilised in antibacterial studies. Aspergillus niger and Candida albicans were used to test the efficacy of antifungal treatments. Ciprofloxacin and fluconazole were utilized as reference medications in antibacterial and antifungal research, respectively. The inhibitory effects ranged from mild to strong across all of the substances. The results of the screenings showed that several of the compounds had stronger antibacterial and antifungal properties than the standard medicines.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136143581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Musbah Abduljalil M. Faraj, Musbah Ahmed M. Buna, Garnasah Ahmed Asmeedah, O. A. Lamma, R. Saheed
In this paper, the geochemical studies of API gravity, content of asphaltenes and gross compositions were performed on samples from two crude oils collected in the Al Bayda Platform Area (Samah formation), central part of the Sirte Basin. The results showed that the fraction of saturates is the dominant fraction in oils in comparison to aromatics and NSO components, with high API gravity and low content of asphaltenes which indicates that the oils are mature, generated from marine organic sources and that they can be classified as light crude oils. The aim of this study is to provide evidence about precursor of organic material, depositional environment, and maturity of the studied oils. Saturated hydrocarbons were analyzed by gas chromatography – mass spectrometry and gas chromatography – mass spectrometry – mass spectrometry technique. Results indicates that the oil samples are originating from high marine organic matter phytoplankton and algae, with few terrestrial inputs, reflecting that oils can be sourced from siliciclastic, possibly marine shales deposited in a clay-rich marine, deposited under intermediate conditions with high maturity. All results showed that the oil samples are similar in their characteristics, likely due to the migration pathways in the same region.
{"title":"Organic Geochemical Investigation of Crude oils from the Al Bayda Platform Area (Samah formation), Central Part of the Sirte Basin, Northern Libya","authors":"Musbah Abduljalil M. Faraj, Musbah Ahmed M. Buna, Garnasah Ahmed Asmeedah, O. A. Lamma, R. Saheed","doi":"10.13005/ojc/390406","DOIUrl":"https://doi.org/10.13005/ojc/390406","url":null,"abstract":"In this paper, the geochemical studies of API gravity, content of asphaltenes and gross compositions were performed on samples from two crude oils collected in the Al Bayda Platform Area (Samah formation), central part of the Sirte Basin. The results showed that the fraction of saturates is the dominant fraction in oils in comparison to aromatics and NSO components, with high API gravity and low content of asphaltenes which indicates that the oils are mature, generated from marine organic sources and that they can be classified as light crude oils. The aim of this study is to provide evidence about precursor of organic material, depositional environment, and maturity of the studied oils. Saturated hydrocarbons were analyzed by gas chromatography – mass spectrometry and gas chromatography – mass spectrometry – mass spectrometry technique. Results indicates that the oil samples are originating from high marine organic matter phytoplankton and algae, with few terrestrial inputs, reflecting that oils can be sourced from siliciclastic, possibly marine shales deposited in a clay-rich marine, deposited under intermediate conditions with high maturity. All results showed that the oil samples are similar in their characteristics, likely due to the migration pathways in the same region.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44134018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Curcuma, a major Zingiberaceae genus, contains approximately 110 species throughout the Asia-Pacific region. The present work aimed to study the two Indian curcuma species, Curcuma caesia Roxb. and Curcuma angustifolia Roxb., whose rhizomes are extracted using ultrasound-assisted extraction (UAE) with chloroform solvent. The extracts are subjected to phytochemical screening and analysed employing gas chromatography-mass spectrometry (GC-MS) procedures. UAE studies of these two Curcuma species' rhizomes using chloroform as a solvent have been conducted for the first time. The chloroform extracts of Curcuma caesia and Curcuma angustifolia contain twenty-six and thirty-two components, respectively. The component with the highest area percentage in both species was 2-cyclohexen-1-one, 4-ethynyl-4-hydroxy-3,5,5-trimethyl (2CEHT), a cyclic unsaturated ketone having anticancer effects. The GC-MS measurement data and phytochemical screening results provide an update on the physiologically active phytoconstituents detected in rhizome extracts, which may be used to standardise crude plant extracts and understand the species' chemical composition and medicinal potential.
{"title":"Comparison Study for the Phytochemical Constituents of two Curcuma Species by GC-MS Technique","authors":"Pravith P Warrier*, Madhavi R Badole","doi":"10.13005/ojc/390418","DOIUrl":"https://doi.org/10.13005/ojc/390418","url":null,"abstract":"Curcuma, a major Zingiberaceae genus, contains approximately 110 species throughout the Asia-Pacific region. The present work aimed to study the two Indian curcuma species, Curcuma caesia Roxb. and Curcuma angustifolia Roxb., whose rhizomes are extracted using ultrasound-assisted extraction (UAE) with chloroform solvent. The extracts are subjected to phytochemical screening and analysed employing gas chromatography-mass spectrometry (GC-MS) procedures. UAE studies of these two Curcuma species' rhizomes using chloroform as a solvent have been conducted for the first time. The chloroform extracts of Curcuma caesia and Curcuma angustifolia contain twenty-six and thirty-two components, respectively. The component with the highest area percentage in both species was 2-cyclohexen-1-one, 4-ethynyl-4-hydroxy-3,5,5-trimethyl (2CEHT), a cyclic unsaturated ketone having anticancer effects. The GC-MS measurement data and phytochemical screening results provide an update on the physiologically active phytoconstituents detected in rhizome extracts, which may be used to standardise crude plant extracts and understand the species' chemical composition and medicinal potential.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47839511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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