Beds of Talchir formation are well exposed in the western part of the Bokaro coalfields (Dudhi Nala) which comprises tillite, conglomerates, sandstones, with dropstones and turbidite sequences comprising siltstones and shales. This work presents the study of glacigenic Talchir sediments of Dudhi Nala section and sediments of Bokaro river. The morphology, major oxides, trace elements, Rare Earth elements and minerals found in these sediments are of great geological importance. The minerals present in these samples have been also investigated. The samples collected from Dudhi Nala are enriched in SiO2 (66-68 wt % compared to 25-60 wt % in the samples of Bokaro river). In contrast to SiO2, Fe2O3 is dominant in the Bokaro river samples. Dudhi Nala samples are rich in trace elements like Ba (1047 ppm), Rb ( 219 ppm), Sr (312 ppm), Zr ( 256 ppm) and Pb (65 ppm), where as Bokaro river samples dominates in Cr (140 ppm), Sc (39 ppm), V (117 ppm) and Zn (90 ppm). FESEM/ EDX analysis was done to study the morphological characteristics and elemental composition were analysed by FESEM/EDX. Thermal characteristics of the samples were studied by TGA/DSC. Further, XRD analysis confirmed that Calcite and feldspar are the common minerals present in the samples of the both the study areas.
{"title":"Quantitative Mineralogical Analysis and Study of Morphology and Thermal Characteristics of Rock Samples of Dudhi Nala and Bokaro River.","authors":"Omprakash Mahato, P. K. Srivastava","doi":"10.13005/ojc/390535","DOIUrl":"https://doi.org/10.13005/ojc/390535","url":null,"abstract":"Beds of Talchir formation are well exposed in the western part of the Bokaro coalfields (Dudhi Nala) which comprises tillite, conglomerates, sandstones, with dropstones and turbidite sequences comprising siltstones and shales. This work presents the study of glacigenic Talchir sediments of Dudhi Nala section and sediments of Bokaro river. The morphology, major oxides, trace elements, Rare Earth elements and minerals found in these sediments are of great geological importance. The minerals present in these samples have been also investigated. The samples collected from Dudhi Nala are enriched in SiO2 (66-68 wt % compared to 25-60 wt % in the samples of Bokaro river). In contrast to SiO2, Fe2O3 is dominant in the Bokaro river samples. Dudhi Nala samples are rich in trace elements like Ba (1047 ppm), Rb ( 219 ppm), Sr (312 ppm), Zr ( 256 ppm) and Pb (65 ppm), where as Bokaro river samples dominates in Cr (140 ppm), Sc (39 ppm), V (117 ppm) and Zn (90 ppm). FESEM/ EDX analysis was done to study the morphological characteristics and elemental composition were analysed by FESEM/EDX. Thermal characteristics of the samples were studied by TGA/DSC. Further, XRD analysis confirmed that Calcite and feldspar are the common minerals present in the samples of the both the study areas.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"100 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136105554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Furfural and cashew nut shell liquid are both renewable resources that can be used for the manufacture of a multitude of useful products. Herein this review is studied to be made concerning the replacement of phenol and aldehyde compounds in the phenolic resin. Cardanol is a phenol-based by-product having an unsaturated alkyl chain and is thus a promising renewable substitute for the development of phenolic resin. This review focuses on the synthesis process of modified phenolic resin by renewable resources, which is further modified by epoxidation, esterification, urea-melamine modification etc. which improved thermal and adhesive and anti-corrosive properties. Mainly phenolic resin is used with natural and synthetic fiber reinforcement and hybrid fiber-reinforced composite, which promote improvements in mechanical properties.
{"title":"Development in the Modification of Phenolic Resin by Renewable Resources: (A-Review)","authors":"Meet Patel, Mitali Yadav, M. Raj","doi":"10.13005/ojc/390407","DOIUrl":"https://doi.org/10.13005/ojc/390407","url":null,"abstract":"Furfural and cashew nut shell liquid are both renewable resources that can be used for the manufacture of a multitude of useful products. Herein this review is studied to be made concerning the replacement of phenol and aldehyde compounds in the phenolic resin. Cardanol is a phenol-based by-product having an unsaturated alkyl chain and is thus a promising renewable substitute for the development of phenolic resin. This review focuses on the synthesis process of modified phenolic resin by renewable resources, which is further modified by epoxidation, esterification, urea-melamine modification etc. which improved thermal and adhesive and anti-corrosive properties. Mainly phenolic resin is used with natural and synthetic fiber reinforcement and hybrid fiber-reinforced composite, which promote improvements in mechanical properties.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49195067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Asa Palakkaden Subramanian, A. Vidyadharan, Chithra Poomala Gopi
The present investigation details the hydrothermal production of RGO-NiO nanocomposite and examines the electrochemical performance of the composite electrode functioning on an adaptable carbon cloth substrate. The RGO-NiO nanostructures display incredible super-capacitive functionality when used in a two-electrode system with a 2 M KOH-PVA electrolyte. This is due to the unique characteristics of RGO, which functions as a flexible and expandable platform for creating NiO nanocrystals with a nanoscopic spherical morphology. Large surface areas in these nanostructures facilitate ion diffusion, which ultimately raises specific capacitance. The nanocomposite electrode as-prepared displays a robust two-electrode structure, a constant potential window between (0V and 0.45V), and specific capacitances of up to 749F/g from CV at a rate of scan of 5mV/s and 366F/g from GCD at 1A/g. 5000 cycles of cyclic stability were examined, and the capacitance retention was 91.23% after successive cycles.
{"title":"Fabrication and Electrochemical Investigation of RGO-NiO Nanocomposite Electrodes for Supercapacitor Applications","authors":"Asa Palakkaden Subramanian, A. Vidyadharan, Chithra Poomala Gopi","doi":"10.13005/ojc/390411","DOIUrl":"https://doi.org/10.13005/ojc/390411","url":null,"abstract":"The present investigation details the hydrothermal production of RGO-NiO nanocomposite and examines the electrochemical performance of the composite electrode functioning on an adaptable carbon cloth substrate. The RGO-NiO nanostructures display incredible super-capacitive functionality when used in a two-electrode system with a 2 M KOH-PVA electrolyte. This is due to the unique characteristics of RGO, which functions as a flexible and expandable platform for creating NiO nanocrystals with a nanoscopic spherical morphology. Large surface areas in these nanostructures facilitate ion diffusion, which ultimately raises specific capacitance. The nanocomposite electrode as-prepared displays a robust two-electrode structure, a constant potential window between (0V and 0.45V), and specific capacitances of up to 749F/g from CV at a rate of scan of 5mV/s and 366F/g from GCD at 1A/g. 5000 cycles of cyclic stability were examined, and the capacitance retention was 91.23% after successive cycles.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49270952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sunil Kumar, Hansraj Sharma, J. Parsad, Jagavendra Yadav, Mangej Singh
By using the spin coating method, Ag ion implanted TiO2 layers were deposited. These thin films were made on a glass substrate that had been meticulously cleaned. The characterization of synthesized Ag-dopped TiO2 thin films by XRD, UV-Vis spectrometer, and SEM with EDX. The outcomes demonstrated the presence of crystalline anatase phase and smooth surface morphologies in the Ag-TiO2 films that were annealed at 5000C. SEM results are utilized to investigate the surface morphology and element identification that has been verified by EDX analysis. The band gap for undoped TiO2 and silver-dopped TiO2 thin films is suggested by the UV-Vis investigation and we get it 2.88eV, 2.96eV, and 3.16eV subsequently. In addition, the findings showed that compared to undoped TiO2 films, the Ag-doped TiO2 film demonstrated higher photocatalytic activity.
{"title":"Effect of Ag ion Implantation on the Crystallinity and Optical Property of Spin-coated TiO2 Thin Films","authors":"Sunil Kumar, Hansraj Sharma, J. Parsad, Jagavendra Yadav, Mangej Singh","doi":"10.13005/ojc/390419","DOIUrl":"https://doi.org/10.13005/ojc/390419","url":null,"abstract":"By using the spin coating method, Ag ion implanted TiO2 layers were deposited. These thin films were made on a glass substrate that had been meticulously cleaned. The characterization of synthesized Ag-dopped TiO2 thin films by XRD, UV-Vis spectrometer, and SEM with EDX. The outcomes demonstrated the presence of crystalline anatase phase and smooth surface morphologies in the Ag-TiO2 films that were annealed at 5000C. SEM results are utilized to investigate the surface morphology and element identification that has been verified by EDX analysis. The band gap for undoped TiO2 and silver-dopped TiO2 thin films is suggested by the UV-Vis investigation and we get it 2.88eV, 2.96eV, and 3.16eV subsequently. In addition, the findings showed that compared to undoped TiO2 films, the Ag-doped TiO2 film demonstrated higher photocatalytic activity.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43183977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. K. Vyas, Sangeeta Rajpurohit, Yudhishthir Vaishnav
A series of benzimidazole derivatives were synthesized for this investigation. NMR and IR spectrum analysis as well as carbon, hydrogen, and nitrogen studies were used to characterize these novel synthesized derivatives. Antibacterial and antifungal tests were conducted on all of the newly synthesized compounds. Ciprofloxacin and fluconazole were utilized as reference medications in antibacterial and antifungal research, respectively. The microbiological assay revealed that the compounds show promising antibacterial and antifungal activity.
{"title":"Synthesis and Characterization of Benzimidazole Derivatives and Evaluation of Antimicrobial activity","authors":"K. K. Vyas, Sangeeta Rajpurohit, Yudhishthir Vaishnav","doi":"10.13005/ojc/390424","DOIUrl":"https://doi.org/10.13005/ojc/390424","url":null,"abstract":"A series of benzimidazole derivatives were synthesized for this investigation. NMR and IR spectrum analysis as well as carbon, hydrogen, and nitrogen studies were used to characterize these novel synthesized derivatives. Antibacterial and antifungal tests were conducted on all of the newly synthesized compounds. Ciprofloxacin and fluconazole were utilized as reference medications in antibacterial and antifungal research, respectively. The microbiological assay revealed that the compounds show promising antibacterial and antifungal activity.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47080704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kevin Jordan Noel, Keerthivasan P, Srikanth V V, R. Srimathi
Medicinal plants are widely valued and are of prime concern globally. Scientific exploration on the flora and fauna of the globe increased, identifying drawbacks in synthetic utility of drugs like poor absorption, high dose, low bioavailability, and poor patient compliance. Plant based pharmaceuticals are considered as an alternative therapy and phytochemicals are being approved as drugs. Our interest is to explore on the spice, Black pepper which is classified under safe herb by FDA. The literature studies are collected estimating the efficacy of the spice against a variety of disease conditions like asthma, diabetes, hyperlipidaemia, inflammation, cancer, oxidative stress, gastrointestinal secretion, lipid metabolism, etc. In this review, we focussed on the scavenging capacity of black pepper in the abduction of free radicals. Increased in the production of free radicals is linked to causing oxidative stress in the body which is underlying cause for many lifestyle disorders like obesity, diabetes, congestive heart failure, myocardial ischemia, and different forms of cancer such as breast, prostate, lung, endometrial, skin, stomach, etc. This review focuses on the efficacy of black pepper and its relationship with many diseases.
{"title":"Black Pepper, Dietary Photochemicals in the Prevention of Diseases by Oxidative Stress (A-Review)","authors":"Kevin Jordan Noel, Keerthivasan P, Srikanth V V, R. Srimathi","doi":"10.13005/ojc/390404","DOIUrl":"https://doi.org/10.13005/ojc/390404","url":null,"abstract":"Medicinal plants are widely valued and are of prime concern globally. Scientific exploration on the flora and fauna of the globe increased, identifying drawbacks in synthetic utility of drugs like poor absorption, high dose, low bioavailability, and poor patient compliance. Plant based pharmaceuticals are considered as an alternative therapy and phytochemicals are being approved as drugs. Our interest is to explore on the spice, Black pepper which is classified under safe herb by FDA. The literature studies are collected estimating the efficacy of the spice against a variety of disease conditions like asthma, diabetes, hyperlipidaemia, inflammation, cancer, oxidative stress, gastrointestinal secretion, lipid metabolism, etc. In this review, we focussed on the scavenging capacity of black pepper in the abduction of free radicals. Increased in the production of free radicals is linked to causing oxidative stress in the body which is underlying cause for many lifestyle disorders like obesity, diabetes, congestive heart failure, myocardial ischemia, and different forms of cancer such as breast, prostate, lung, endometrial, skin, stomach, etc. This review focuses on the efficacy of black pepper and its relationship with many diseases.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45717336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Polyphenol oxidases (PPO) are enzymes that catalyze the browning of fruits and vegetables when oxygen in the air reacts with the present phenolic compounds. This study demonstrates the enzymatic browning of food samples and the inhibition of its activity by common household materials. Fresh food samples were tested in different treatments of acidic and ionic solutions, and syrups. Observations from the students’ work showed that changes in pH, surface area for the site of reaction, and ionic conditions affect enzymatic browning. The deviation from the optimum working pH, introduction of ionic interaction, and alteration of the surface area led to the interruption of the interaction within the enzyme structure and between its active site and the substrate thereby inhibiting the enzyme function. Results of the experiment can also serve as a basis for further studies on the development of methods and products to inhibit PPO action and maintain the sensory value and nutritional quality of foods. Furthermore, experiments of similar nature can be crafted as practical activities and alternative teaching techniques designed for students to apply chemistry concepts and laboratory fundamentals to the conduct of an experiment suited for the flexible learning set- up.
{"title":"Enzymatic Activity of Polyphenol Oxidase: A Laboratory Experiment in Flexible Learning","authors":"Dyanne Jane Cid Duldulao","doi":"10.13005/ojc/390405","DOIUrl":"https://doi.org/10.13005/ojc/390405","url":null,"abstract":"Polyphenol oxidases (PPO) are enzymes that catalyze the browning of fruits and vegetables when oxygen in the air reacts with the present phenolic compounds. This study demonstrates the enzymatic browning of food samples and the inhibition of its activity by common household materials. Fresh food samples were tested in different treatments of acidic and ionic solutions, and syrups. Observations from the students’ work showed that changes in pH, surface area for the site of reaction, and ionic conditions affect enzymatic browning. The deviation from the optimum working pH, introduction of ionic interaction, and alteration of the surface area led to the interruption of the interaction within the enzyme structure and between its active site and the substrate thereby inhibiting the enzyme function. Results of the experiment can also serve as a basis for further studies on the development of methods and products to inhibit PPO action and maintain the sensory value and nutritional quality of foods. Furthermore, experiments of similar nature can be crafted as practical activities and alternative teaching techniques designed for students to apply chemistry concepts and laboratory fundamentals to the conduct of an experiment suited for the flexible learning set- up.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44625958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the present study, Methylene blue immobilized resin (MBIR) Dowex-1x8, an effective heterogeneous photocatalyst, is used to perform the photocatalytic degradation of Biebrich Scarlet (BS) Textile dye. The degradation of the dye was systematically investigated under different parameters such as pH of the Biebrich Scarlet dye solution, different Photocatalyst doses, dye solution concentrations, and UV/Visible light intensity. Optimum results are shown for various parameters, such as temperature of 30oC, pH of 7.5, photocatalyst loading dose of 2.0 g, and light intensity of 10.5mW/cm2. Maximum degradation is shown on the above optimum condition and complete degradation was held in 210 minutes on the above optimum condition.
{"title":"Degradation of Biebrich Scarlet Textile Dye by using MBIR Dowex-1x8","authors":"L. Yadav, H. Jaimini, R. Meena, S. L. Meena","doi":"10.13005/ojc/390416","DOIUrl":"https://doi.org/10.13005/ojc/390416","url":null,"abstract":"In the present study, Methylene blue immobilized resin (MBIR) Dowex-1x8, an effective heterogeneous photocatalyst, is used to perform the photocatalytic degradation of Biebrich Scarlet (BS) Textile dye. The degradation of the dye was systematically investigated under different parameters such as pH of the Biebrich Scarlet dye solution, different Photocatalyst doses, dye solution concentrations, and UV/Visible light intensity. Optimum results are shown for various parameters, such as temperature of 30oC, pH of 7.5, photocatalyst loading dose of 2.0 g, and light intensity of 10.5mW/cm2. Maximum degradation is shown on the above optimum condition and complete degradation was held in 210 minutes on the above optimum condition.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41901473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Copper zinc tin sulphide (CZTS) has emerged as a highly promising, cost-effective, and environmentally friendly material for solar energy conversion via photovoltaic and photocatalysis. This paper presents the synthesis of quasi Cu2ZnSnS4 nanoparticles using a hydrothermal route with citric acid as a structure-directing agent. The CZTS nanoparticles' morphological, structural, and optical properties were comprehensively analysed using X-ray diffraction, scanning electron microscopy, and UV-Vis absorption studies. The results demonstrate the successful synthesis of CZTS nanoparticles with a novel narrow size distribution, making them excellent candidates as absorber layers in solar cells. This discovery holds significant potential for advancing low-cost and efficient solar energy conversion technologies. By harnessing the unique properties of CZTS, this research offers a promising solution towards sustainable energy production and a greener future.
{"title":"Optically Important Cu2 ZnSnS4 (CZTS) Nanoparticles Synthesis using a Hydrothermal Route with Citric acid as a Structure Directing Agent","authors":"B. Pandey, Y. Goswami","doi":"10.13005/ojc/390429","DOIUrl":"https://doi.org/10.13005/ojc/390429","url":null,"abstract":"Copper zinc tin sulphide (CZTS) has emerged as a highly promising, cost-effective, and environmentally friendly material for solar energy conversion via photovoltaic and photocatalysis. This paper presents the synthesis of quasi Cu2ZnSnS4 nanoparticles using a hydrothermal route with citric acid as a structure-directing agent. The CZTS nanoparticles' morphological, structural, and optical properties were comprehensively analysed using X-ray diffraction, scanning electron microscopy, and UV-Vis absorption studies. The results demonstrate the successful synthesis of CZTS nanoparticles with a novel narrow size distribution, making them excellent candidates as absorber layers in solar cells. This discovery holds significant potential for advancing low-cost and efficient solar energy conversion technologies. By harnessing the unique properties of CZTS, this research offers a promising solution towards sustainable energy production and a greener future.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47746613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dillip Kumar Dash, A. Sen, S. Saisivam, A. Zanwar, S. Patel, Dhanya B. Sen
A straightforward RP-HPLC approach has been developed and validated for the simultaneous estimation of drotaverine hydrochloride (DROTA) and diclofenac potassium (DICLO) in their combined dosage form. This method was found to be simple, accurate, and precise. Chromatographic detection has been carried out on a Phenomenex C18 column (250 mm × 4.6 mm, i.d, 5 µm) with a flow rate of 1.0 ml/min using an isocratic mobile phase consisting of Methanol and Water (80:20 v/v, pH 3 adjusted with ortho phosphoric acid). The wavelength of 280 nm was chosen for the UV detection. The separation of DROTA and DICLO took less than ten minutes, had a good resolution, and produced very little tailing. There was no interference from any excipients. The method was validated in accordance with the ICH recommendations, and the criteria for accuracy, precision, linearity, and system adaptability were all satisfactory in each and every one of the cases.
建立了一种简单的反相高效液相色谱法(RP-HPLC)，用于同时测定盐酸氯他弗林(DROTA)和双氯芬酸钾(DICLO)的联合剂型。该方法简便、准确、精密度高。色谱检测采用Phenomenex C18色谱柱(250 mm × 4.6 mm, i.d, 5µm)，流速为1.0 ml/min，流动相为甲醇和水(80:20 v/v, pH 3用邻位磷酸调节)。选择280 nm波长进行紫外检测。DROTA和DICLO的分离用时不到10分钟，分辨率很好，产生的尾矿很少。没有任何辅料的干扰。该方法按照ICH建议进行了验证，准确度、精密度、线性度和系统适应性的标准在每个案例中都是令人满意的。
{"title":"Development of a Chromatographic Technique for Quantification of Drotaverine Hydrochloride and Diclofenac Potassium","authors":"Dillip Kumar Dash, A. Sen, S. Saisivam, A. Zanwar, S. Patel, Dhanya B. Sen","doi":"10.13005/ojc/390420","DOIUrl":"https://doi.org/10.13005/ojc/390420","url":null,"abstract":"A straightforward RP-HPLC approach has been developed and validated for the simultaneous estimation of drotaverine hydrochloride (DROTA) and diclofenac potassium (DICLO) in their combined dosage form. This method was found to be simple, accurate, and precise. Chromatographic detection has been carried out on a Phenomenex C18 column (250 mm × 4.6 mm, i.d, 5 µm) with a flow rate of 1.0 ml/min using an isocratic mobile phase consisting of Methanol and Water (80:20 v/v, pH 3 adjusted with ortho phosphoric acid). The wavelength of 280 nm was chosen for the UV detection. The separation of DROTA and DICLO took less than ten minutes, had a good resolution, and produced very little tailing. There was no interference from any excipients. The method was validated in accordance with the ICH recommendations, and the criteria for accuracy, precision, linearity, and system adaptability were all satisfactory in each and every one of the cases.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48353672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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