Oral diseases最新文献

Objectives: To evaluate evidence in relation to postoperative bleeding in humans aged ≥ 16 with preoperative platelet counts < 50,000/μL, compared to those above, undergoing dental interventions.

Methods: Quantitative synthesis without meta-analysis was conducted through an electronic search conducted on Ovid MEDLINE and Embase from 1946 to April 2024 with no restriction on study design. Primary outcome was postoperative bleeding in patients with platelet count < 50,000/μL due to dental interventions. Two reviewers assessed independently, and a third resolved conflicts. This study was reported according to PRISMA 2020 and registered on PROSPERO (CRD42024527279).

Results: 1633 unique articles were identified. Six case reports, four case series, nine cohort studies and one trial fulfilled the inclusion. Overall, 983 included cases consisted of 968 oral surgery, 10 periodontology and 5 dental anaesthesia cases. Postoperative bleeding occurred in 65 cases following oral surgery procedures, of which 1 was life-threatening. Bleeding rates for cases with platelet levels < 50,000/μL were 12.9%, and 4.9% for ≥ 50,000/μL. Risk ratio was 2.95 (95% CI: 1.76-4.96; p < 0.0001).

Conclusions: There is no evidence that platelet counts < 50,000/μL is a contraindication for dental interventions, although findings suggest higher postoperative bleeding rates, particularly in oral surgery. Patients should be assessed individually, with more controlled trials required.

Objective: This trial aimed to assess the adjunctive therapeutic effect of low-intensity pulsed ultrasound (LIPUS) in promoting bone regeneration following jaw cyst enucleation with curettage.

Methods: This triple-blinded, randomized trial enrolled 29 patients (33 jaw cysts) undergoing enucleation. 17 patients (18 cysts) received daily LIPUS therapy for 10 days (Ultrasound group), while 12 patients (15 cysts) received sham LIPUS therapy (control group). Volumetric changes of the cystic cavities and bone density (relative Hounsfield units) were assessed at baseline, at 3, and 6 months following LIPUS therapy.

Results: At the 3rd month, a significant reduction in cyst volume was observed in the Ultrasound group, which showed a 63% reduction, compared to a 35% reduction in the control group (p = 0.031). By the 6th month, the Ultrasound group demonstrated a further decrease in volume compared to the control group (82% vs. 61%; p = 0.027). Moreover, LIPUS therapy consistently resulted in significantly greater bone density than the control group at both 3 and 6 months (p = 0.026 and p = 0.031, respectively).

Conclusions: Adjunctive LIPUS therapy following jaw cyst enucleation improves bone regeneration postoperatively without adverse effects. LIPUS is a promising non-invasive method for promoting bone healing post-enucleation.

Trial registration: Thailand Clinical Trials Registry on June 16, 2025 (https://www.thaiclinicaltrials.org/show/TCTR20250616017).

Objectives: The aim of this study was to develop and validate a questionnaire for assessing the knowledge, attitude and practice (KAP) related to the daily management of oral lichen planus (OLP).

Materials and methods: A 25-item questionnaire with three dimensions was developed. Using convenience sampling, 136 OLP patients from a tertiary hospital in Guangdong Province (December 2023-April 2024) completed the survey. Among them, 30 patients were retested 2-4 weeks after the initial survey, during which no participants received any OLP-related health education interventions. Reliability was evaluated using Cronbach's α coefficient, split-half reliability, and test-retest reliability, while validity was assessed via the content validity index, exploratory factor analysis, and confirmatory factor analysis.

Results: The questionnaire showed strong reliability (Cronbach's α = 0.923; test-retest reliability = 0.909) and validity (content validity index = 0.93). Factor analysis identified three dimensions, explaining 60.84% of the total variance, with adequate model fit indices.

Conclusions: This validated 25-item questionnaire (covering knowledge, attitude, and practice dimensions) serves as an initial, reliable measure of OLP-related knowledge, attitudes, and self-management practices with acceptable construct validity in a single-center sample.