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Authors' Reply "Effects of Bisphosphonates and Denosumab on Dental Implants: A Systematic Review With Meta-Analysis". 作者回复“双膦酸盐和Denosumab对牙种植体的影响:一项荟萃分析的系统综述”。
IF 2.9 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-04 DOI: 10.1111/odi.70190
Linni Lin, Yijie Ren, Xia Wang, Qianqian Yao
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引用次数: 0
Authors' Reply "Histochemical Assessment of Cementum and Alveolar Bone in SDT fa/fa Rat Mimicking Type II Diabetes". 作者回复“模拟2型糖尿病的SDT fa/fa大鼠骨质和牙槽骨的组织化学评价”。
IF 2.9 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-04 DOI: 10.1111/odi.70191
Tomoka Hasegawa, Mako Sakakibara, Xuanyu Liu, Mai Haraguchi-Kitakamae, Weisong Li, Haoyu Wang, Yan Shi, Jiaxin Cui, Hiromi Hongo, Tomomaya Yamamoto, Miki Abe-Takagi, Haruhi Maruoka, Hirofumi Miyaji, Minqi Li, Norio Amizuka
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引用次数: 0
The Effect of Rehabilitation Interventions on Trismus in Oral Cancer Patients: A Systematic Review. 康复干预对口腔癌患者牙关紧闭的影响:一项系统综述。
IF 2.9 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-04 DOI: 10.1111/odi.70185
Huipin Wang, Yameng An, Dongling Liu

Objective: To systematically evaluate rehabilitation interventions for oral cancer patients with trismus and clarify effects on trismus.

Materials and methods: A comprehensive search for randomized controlled trials and quasi-experimental studies published up to November 28, 2024, was conducted across PubMed, Embase, Cochrane Library, Web of Science, CINAHL, CBM, CNKI, VIP, and Wanfang using the PICOS strategy. The primary outcome was mouth opening distance. Two authors independently assessed risk of bias and methodological quality using the Cochrane Handbook (version 5.1.0) and ROBINS-I. The study protocol was registered with PROSPERO (CRD42024613003).

Results: The review included 15 articles, including eight randomized controlled trials and seven quasi-experimental studies. There were variations in the timing and type of rehabilitation. Most interventions started 2-3 weeks post-surgery. Three types of interventions, including exercise training, physical therapy, and speech training, improved trismus.

Conclusion: Rehabilitation interventions are often used in combination, but the effectiveness of individual interventions remains unclear. Physical therapy has been shown to alleviate pain, while remote reminders can enhance adherence. Only a basic consensus on rehabilitation interventions can be summarized due to design differences. Future research should focus on conducting rigorous trials to provide more conclusive evidence.

目的:系统评价口腔癌合并牙关的康复干预措施,明确其对牙关的治疗效果。材料与方法:采用PICOS策略,在PubMed、Embase、Cochrane Library、Web of Science、CINAHL、CBM、CNKI、VIP、万方等网站上全面检索截止到2024年11月28日发表的随机对照试验和准实验研究。主要观察指标为张口距离。两位作者使用Cochrane手册(5.1.0版)和ROBINS-I独立评估偏倚风险和方法学质量。研究方案已在PROSPERO注册(CRD42024613003)。结果:纳入文献15篇,包括8项随机对照试验和7项准实验研究。康复的时间和类型各不相同。大多数干预开始于手术后2-3周。运动训练、物理治疗和言语训练三种干预措施均可改善咬牙症。结论:康复干预措施经常联合使用,但个别干预措施的效果尚不清楚。物理治疗已被证明可以减轻疼痛,而远程提醒可以增强依从性。由于设计上的差异,在康复干预方面只能总结出一个基本的共识。未来的研究应侧重于进行严格的试验,以提供更确凿的证据。
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引用次数: 0
Incident Lung Cancer and Mortality: Data From Health ABC Using Periodontal Status and Tooth Loss. 肺癌发病率和死亡率:使用牙周状况和牙齿脱落的健康ABC数据。
IF 2.9 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-04 DOI: 10.1111/odi.70178
Taciane Menezes da Silveira, Eleanor M Simonsick, Juliana Balbinot Hilgert, Fernando Neves Hugo, Francisco Wilker Mustafa Gomes Muniz, Natália Marcumini Pola

Aim: To evaluate whether periodontal parameters and tooth loss are associated with lung cancer incidence and mortality among older adults.

Materials and methods: Data are from the Health, Aging and Body Composition (Health ABC) study, which included 1136 older adults who received a periodontal examination and were followed for up to 16 years. Pocket depth and clinical attachment level were assessed for all present teeth. Adjusted Cox regression models were used to examine the relationship between periodontal parameters and number of natural teeth with lung cancer incidence and mortality.

Results: Lung cancer incidence was 4.4% (n = 50) and was identified as cause of death in 3.3% (n = 38). Those presenting at least 10% of sites with probing depth ≥ 6 mm demonstrated a higher risk of lung cancer and death due to lung cancer (hazard ratio [HR]: 3.12, 95% confidence interval [CI]: 1.45-6.72 and HR: 3.08, 95% CI: 1.27-7.46), respectively. Tooth loss was associated with a reduced hazard of lung cancer incidence (HR: 0.96; 95% CI: 0.93-0.99) and related mortality (HR: 0.96; 95% CI: 0.92-0.99).

Conclusion: The association between severe periodontal disease parameters and tooth loss with lung cancer among older adults underscores the importance of oral health maintenance for cancer prevention strategies.

目的:评价牙周参数和牙齿脱落是否与老年人肺癌发病率和死亡率相关。材料和方法:数据来自健康、衰老和身体组成(Health ABC)研究,该研究包括1136名接受牙周检查的老年人,并随访长达16年。评估所有牙齿的牙袋深度和临床附着水平。采用调整后的Cox回归模型检验牙周参数和天然牙数与肺癌发病率和死亡率的关系。结果:肺癌发病率为4.4% (n = 50), 3.3% (n = 38)被确定为死亡原因。检出至少10%的探查深度≥6 mm部位的患者患肺癌和死于肺癌的风险更高(风险比[HR]: 3.12, 95%可信区间[CI]: 1.45-6.72;风险比:3.08,95%可信区间[CI]: 1.27-7.46)。牙齿脱落与肺癌发病率降低(相对危险度:0.96;95% CI: 0.93-0.99)和相关死亡率(相对危险度:0.96;95% CI: 0.92-0.99)相关。结论:老年人严重牙周病参数和牙齿脱落与肺癌之间的关系强调了口腔健康维护对癌症预防策略的重要性。
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引用次数: 0
Correction to "Targeted Therapies in Ameloblastomas and Ameloblastic Carcinoma-A Systematic Review". 修正“成釉细胞瘤和成釉细胞癌的靶向治疗-系统性综述”。
IF 2.9 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-02 DOI: 10.1111/odi.70175
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引用次数: 0
Diagnostic Comparison and Threshold Optimization of 5Ts and 6Ts TMD Screeners. 5Ts和6Ts TMD筛查者的诊断比较及阈值优化。
IF 2.9 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-01-02 DOI: 10.1111/odi.70184
Adrian Ujin Yap, Jie Lei, Chengge Liu, Kai Yuan Fu
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引用次数: 0
Exposure to Famine in Early Childhood Increases the Odds of Edentulism in Adulthood: Results From the China Health and Retirement Longitudinal Study. 儿童早期遭受饥荒会增加成年后患无牙症的几率:来自中国健康与退休纵向研究的结果。
IF 2.9 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-30 DOI: 10.1111/odi.70177
Dingfa Gu, Xiaoyan Chen, Dan Zheng, Yurong Leng, Xiaolin Lu, Jiaqin Wang

Background: This study examined the impact of early childhood exposure to China's 1959-1961 famine on the likelihood of adult edentulism.

Methods: We used data from 8209 adults surveyed in 2011-2012 China Health and Retirement Longitudinal Study (CHARLS). Logistic regression was used to analyze the odds ratios (ORs) and confidence intervals (CIs) of early starvation and edentulism in adulthood.

Results: Compared with unexposed individuals, famine-exposed individuals had a significantly increased odds of edentulism. After adjustment for age, sex, location, severity, income, education, smoking, drinking, hypertension, dyslipidaemia, diabetes, and heart disease, the final ORs (95% CIs) were 2.097 (1.047, 4.355) for the foetal exposure group, 2.625 (1.245, 5.746) for the preschool group, and 3.907 (1.608, 9.726) for the school-age exposure group.

Conclusions: Exposure to China's 1959-1961 famine during early childhood is associated with significantly increased odds of edentulism in adulthood, particularly among those exposed during school age (OR = 3.907; 95% CI: 1.608-9.726).

背景:本研究考察了儿童早期暴露于中国1959-1961年大饥荒对成人患蛀牙症可能性的影响。方法:我们使用2011-2012年中国健康与退休纵向研究(CHARLS)调查的8209名成年人的数据。采用Logistic回归分析成年期早期饥饿与全牙化的比值比(ORs)和置信区间(CIs)。结果:与未暴露的个体相比,饥荒暴露的个体有明显增加的登牙率。调整年龄、性别、居住地、严重程度、收入、受教育程度、吸烟、饮酒、高血压、血脂异常、糖尿病、心脏病等因素后,胎儿暴露组的最终ORs (95% ci)为2.097(1.047,4.355),学龄前暴露组为2.625(1.245,5.746),学龄暴露组为3.907(1.608,9.726)。结论:儿童早期暴露于中国1959-1961年的饥荒与成年后长牙的几率显著增加有关,特别是在学龄期暴露的人(OR = 3.907; 95% CI: 1.608-9.726)。
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引用次数: 0
A Novel Approach to Assessing Oral Health Status in Hashimoto's Thyroiditis: Perspective of Ultrasonography. 一种评估桥本甲状腺炎患者口腔健康状况的新方法:超声透视。
IF 2.9 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-30 DOI: 10.1111/odi.70180
Emre Can Kaya, Sumeyye Celik Ozsoy, Samed Satir
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引用次数: 0
A Retrospective Analysis of Positional and Dimensional Changes in Temporomandibular Joint Following Mandibular Reconstruction With Fibula Flap and Influencing Factors Behind. 腓骨瓣重建下颌骨后颞下颌关节位置、尺寸变化及其影响因素的回顾性分析。
IF 2.9 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-30 DOI: 10.1111/odi.70176
Maged Ali Al-Aroomi, Yiheng Feng, Naseem Ali Al-Worafi, Jie Chen, Saiwen Song, Canhua Jiang, Ye Liang, Jie Wang

Objectives: Stable condyle positioning is crucial for temporomandibular joint (TMJ) function, but its long-term stability in patients undergoing segmental mandibulectomy with free fibular flap (FFF) reconstruction is unclear. This study aimed to assess the long-term stability of TMJ parameters and the factors influencing it.

Methods: This retrospective study included patients who underwent mandibular reconstruction using FFF with condyle preservation. CBCT was used to assess TMJ measurements at four time points: pre-surgery (T0), 1 ± 1 month (T1), 6 ± 1 months (T2), and at least 20 ± 4 months post-surgery (T3). Parameters such as condylar inclination, position, dimensions, and joint spaces were measured.

Results: A total of 89 patients participated (51 with conventional freehand, 38 with 3D procedure). Condylar position changed over time: the operated side showed a slight downward shift, and the contralateral side showed inward and medial movement. Factors affecting condylar stability included surgical accuracy, mandible angle involvement, defect location (especially if crossing midline), and postoperative radiation therapy (p < 0.05).

Conclusion: TMJ parameters are highly sensitive to skeletal changes post-reconstruction with condylar preservation. Our findings suggest that condylar position lacks long-term stability after surgery. Further studies are needed to assess clinical outcomes and disc-condyle relationship after mandibular reconstruction.

目的:稳定的髁突定位对颞下颌关节(TMJ)功能至关重要,但其在接受下颌节段切除游离腓骨瓣(FFF)重建患者中的长期稳定性尚不清楚。本研究旨在评估颞下颌关节参数的长期稳定性及其影响因素。方法:本回顾性研究包括采用保留髁突的FFF进行下颌骨重建的患者。采用CBCT在术前(T0)、1±1个月(T1)、6±1个月(T2)和术后至少20±4个月(T3)四个时间点评估TMJ测量。测量了髁突倾角、位置、尺寸和关节间隙等参数。结果:共89例患者参与,其中徒手手术51例,3D手术38例。髁突位置随时间变化:手术侧轻微下移,对侧向内内侧运动。影响髁稳定性的因素包括手术精度、下颌受侵角度、缺损位置(尤其是跨越中线)和术后放射治疗。(p)结论:保留髁突重建后TMJ参数对骨骼变化高度敏感。我们的研究结果表明,术后髁突位置缺乏长期稳定性。需要进一步的研究来评估下颌骨重建后的临床结果和椎间盘与髁突的关系。
{"title":"A Retrospective Analysis of Positional and Dimensional Changes in Temporomandibular Joint Following Mandibular Reconstruction With Fibula Flap and Influencing Factors Behind.","authors":"Maged Ali Al-Aroomi, Yiheng Feng, Naseem Ali Al-Worafi, Jie Chen, Saiwen Song, Canhua Jiang, Ye Liang, Jie Wang","doi":"10.1111/odi.70176","DOIUrl":"https://doi.org/10.1111/odi.70176","url":null,"abstract":"<p><strong>Objectives: </strong>Stable condyle positioning is crucial for temporomandibular joint (TMJ) function, but its long-term stability in patients undergoing segmental mandibulectomy with free fibular flap (FFF) reconstruction is unclear. This study aimed to assess the long-term stability of TMJ parameters and the factors influencing it.</p><p><strong>Methods: </strong>This retrospective study included patients who underwent mandibular reconstruction using FFF with condyle preservation. CBCT was used to assess TMJ measurements at four time points: pre-surgery (T0), 1 ± 1 month (T1), 6 ± 1 months (T2), and at least 20 ± 4 months post-surgery (T3). Parameters such as condylar inclination, position, dimensions, and joint spaces were measured.</p><p><strong>Results: </strong>A total of 89 patients participated (51 with conventional freehand, 38 with 3D procedure). Condylar position changed over time: the operated side showed a slight downward shift, and the contralateral side showed inward and medial movement. Factors affecting condylar stability included surgical accuracy, mandible angle involvement, defect location (especially if crossing midline), and postoperative radiation therapy (p < 0.05).</p><p><strong>Conclusion: </strong>TMJ parameters are highly sensitive to skeletal changes post-reconstruction with condylar preservation. Our findings suggest that condylar position lacks long-term stability after surgery. Further studies are needed to assess clinical outcomes and disc-condyle relationship after mandibular reconstruction.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145864454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Independent Multicentre Validation of the 'Six-Point' Model for Malignant Transformation Risk in Oral Epithelial Dysplasia. 口腔上皮发育不良恶性转化风险“六点”模型的独立多中心验证
IF 2.9 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-26 DOI: 10.1111/odi.70173
Hanya Mahmood, Mike Bradburn, Nadim M Islam, Omar Kujan, Nasir Rajpoot, Alan Roger Santos-Silva, Pablo Agustin Vargas, Jacqueline James, Paul Nankivell, Hisham Mehanna, Syed Ali Khurram

Background: Histological grading of oral epithelial dysplasia (OED) is used for predicting malignant transformation risk. However, grading is associated with significant subjectivity and observer variability leading to inconsistency in prognosis prediction. Alternate histological feature-specific models ('six-point' and 'two-point') have been shown to have potentially better prognostic reliability than conventional grading. This study conducts a multicentre validation of these models.

Methods: 102 OED cases (dating 2012-2017) were acquired from 4 independent centres (13 (13%) Sheffield; 40 (39%) Belfast; 30 (29%) Birmingham; 19 (19%) Piracicaba, Brazil) were independently scored using the 'six-point' and 'two-point' models. Feature prevalence, observer agreement and malignant transformation risk were evaluated and compared to conventional grading systems.

Results: The 'six-point' system demonstrated superior predictive value (AUROC of 0.81) compared to the 'two-point' system (AUROC = 0.73, p = 0.004), WHO grading (AUROC = 0.71, p = 0.03) and binary grading (AUROC = 0.68, p = 0.009). Transformation rate for the 'six-point' model was 50% (95% CI 27%-78%) when all 6 features were present compared to 14% (95% CI 5%-32%) when 2-3 features were present.

Conclusions: This study supports the superior performance of the 'six-point' system for transformation prediction on a multicentric sample. Findings indicate that feature-specific models may be more reliable than existing histological grading systems for prognosis prediction.

背景:口腔上皮发育不良(OED)的组织学分级用于预测恶性转化的风险。然而,分级与显著的主观性和观察者可变性相关,导致预后预测不一致。替代的组织学特征特异性模型(“6分”和“2分”)已被证明具有比传统分级更好的潜在预后可靠性。本研究对这些模型进行了多中心验证。方法:从4个独立中心获得102例OED病例(2012-2017年)(13例(13%)谢菲尔德;40(39%)贝尔法斯特;30个(29%)伯明翰;19(19%)皮拉西卡巴(Piracicaba,巴西)使用“六点”和“两点”模型独立评分。评估特征患病率、观察者一致性和恶性转化风险,并比较常规分级系统。结果:“6分制”的预测价值(AUROC为0.81)优于“2分制”(AUROC = 0.73, p = 0.004)、WHO分级(AUROC = 0.71, p = 0.03)和二元分级(AUROC = 0.68, p = 0.009)。当所有6个特征都存在时,“六点”模型的转化率为50% (95% CI 27%-78%),而当2-3个特征存在时,转化率为14% (95% CI 5%-32%)。结论:本研究支持“六点”系统在多中心样本上的转化预测的优越性能。研究结果表明,特征特异性模型可能比现有的组织学分级系统更可靠。
{"title":"Independent Multicentre Validation of the 'Six-Point' Model for Malignant Transformation Risk in Oral Epithelial Dysplasia.","authors":"Hanya Mahmood, Mike Bradburn, Nadim M Islam, Omar Kujan, Nasir Rajpoot, Alan Roger Santos-Silva, Pablo Agustin Vargas, Jacqueline James, Paul Nankivell, Hisham Mehanna, Syed Ali Khurram","doi":"10.1111/odi.70173","DOIUrl":"https://doi.org/10.1111/odi.70173","url":null,"abstract":"<p><strong>Background: </strong>Histological grading of oral epithelial dysplasia (OED) is used for predicting malignant transformation risk. However, grading is associated with significant subjectivity and observer variability leading to inconsistency in prognosis prediction. Alternate histological feature-specific models ('six-point' and 'two-point') have been shown to have potentially better prognostic reliability than conventional grading. This study conducts a multicentre validation of these models.</p><p><strong>Methods: </strong>102 OED cases (dating 2012-2017) were acquired from 4 independent centres (13 (13%) Sheffield; 40 (39%) Belfast; 30 (29%) Birmingham; 19 (19%) Piracicaba, Brazil) were independently scored using the 'six-point' and 'two-point' models. Feature prevalence, observer agreement and malignant transformation risk were evaluated and compared to conventional grading systems.</p><p><strong>Results: </strong>The 'six-point' system demonstrated superior predictive value (AUROC of 0.81) compared to the 'two-point' system (AUROC = 0.73, p = 0.004), WHO grading (AUROC = 0.71, p = 0.03) and binary grading (AUROC = 0.68, p = 0.009). Transformation rate for the 'six-point' model was 50% (95% CI 27%-78%) when all 6 features were present compared to 14% (95% CI 5%-32%) when 2-3 features were present.</p><p><strong>Conclusions: </strong>This study supports the superior performance of the 'six-point' system for transformation prediction on a multicentric sample. Findings indicate that feature-specific models may be more reliable than existing histological grading systems for prognosis prediction.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Oral diseases
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