Pub Date : 2024-09-01Epub Date: 2024-03-04DOI: 10.1111/odi.14914
Linda Sangalli, Alesia V Prakapenka, Akhilanand Chaurasia, Craig S Miller
Objectives: The underlying mechanisms of burning mouth syndrome (BMS) remain unclear leading to challenges and unsatisfactory management. Current treatments focus primarily on symptom relief, with few consistently achieving a 50% reduction in pain. This review aims to explore animal models of BMS to gain a better understanding of the underlying mechanisms and to discuss potential and existing knowledge gaps.
Methods: A comprehensive review of PubMed®, Google Scholar, and Scopus was performed to assess advances and significant gaps of existing rodent models that mimic BMS-related symptoms.
Results: Rodent models of BMS involve reproduction of dry-tongue, chorda tympani transection, or overexpression of artemin protein. Existing preclinical models tend to highlight one specific etiopathogenesis and often overlook sex- and hormone-specific factors.
Conclusion: Combining aspects from various BMS models could prove beneficial in developing comprehensive experimental designs and outcomes encompassing the multifaceted nature of BMS.
{"title":"A review of animal models for burning mouth syndrome: Mechanistic insights and knowledge gaps.","authors":"Linda Sangalli, Alesia V Prakapenka, Akhilanand Chaurasia, Craig S Miller","doi":"10.1111/odi.14914","DOIUrl":"10.1111/odi.14914","url":null,"abstract":"<p><strong>Objectives: </strong>The underlying mechanisms of burning mouth syndrome (BMS) remain unclear leading to challenges and unsatisfactory management. Current treatments focus primarily on symptom relief, with few consistently achieving a 50% reduction in pain. This review aims to explore animal models of BMS to gain a better understanding of the underlying mechanisms and to discuss potential and existing knowledge gaps.</p><p><strong>Methods: </strong>A comprehensive review of PubMed<sup>®</sup>, Google Scholar, and Scopus was performed to assess advances and significant gaps of existing rodent models that mimic BMS-related symptoms.</p><p><strong>Results: </strong>Rodent models of BMS involve reproduction of dry-tongue, chorda tympani transection, or overexpression of artemin protein. Existing preclinical models tend to highlight one specific etiopathogenesis and often overlook sex- and hormone-specific factors.</p><p><strong>Conclusion: </strong>Combining aspects from various BMS models could prove beneficial in developing comprehensive experimental designs and outcomes encompassing the multifaceted nature of BMS.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140028612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2024-01-15DOI: 10.1111/odi.14850
Lucyana Conceição Farias, Samuel Trezena, Hebert Cleiton Ferreira de Souza, Ricardo D Coletta, Hercílio Martelli-Junior
{"title":"Internationalization of the Brazilian groups dedicated to oral pathology and oral medicine.","authors":"Lucyana Conceição Farias, Samuel Trezena, Hebert Cleiton Ferreira de Souza, Ricardo D Coletta, Hercílio Martelli-Junior","doi":"10.1111/odi.14850","DOIUrl":"10.1111/odi.14850","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139472849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2023-11-20DOI: 10.1111/odi.14813
Jamie M Alberga, Arjan Vissink, Anke Korfage, Sebastiaan A H J de Visscher, Max J H Witjes, Johannes A Langendijk, Gerry M Raghoebar
Objectives: We assessed the radiation dosages (Dmean) on implant regions to identify the threshold for implant loss in patients with an intraoral malignancy treated with dental implants to support a mandibular denture during ablative surgery before volumetric-modulated arc therapy (VMAT).
Materials and methods: Data was collected prospectively from 28 patients treated surgically for an intraoral malignancy, followed by postoperative radiotherapy (VMAT) and analyzed retrospectively. Patients received 2 implants in the native mandible during ablative surgery. Implant-specific Dmean values were retrieved from the patients' files. Radiographic bone loss was measured 1 year after implant placement and during the last follow-up appointment. Implant survival was analyzed with the Kaplan-Meier method. Univariate logistic regression and Cox-regression analyses were performed to investigate the effect of increasing implant-specific radiation dosages on implant loss.
Results: Five out of 56 placed implants were lost during follow-up (median 36.0 months, IQR 39.0). Radiographically, peri-implant bone loss occurred in implants with a Dmean > 40 Gy. Implant loss occurred only in implants with a Dmean > 50 Gy.
Conclusion: An implant-specific Dmean higher than 50 Gy is related to more peri-implant bone loss and, eventually, implant loss.
{"title":"Site-specific radiation dosage and implant survival in oral cancer patients: A cohort study.","authors":"Jamie M Alberga, Arjan Vissink, Anke Korfage, Sebastiaan A H J de Visscher, Max J H Witjes, Johannes A Langendijk, Gerry M Raghoebar","doi":"10.1111/odi.14813","DOIUrl":"10.1111/odi.14813","url":null,"abstract":"<p><strong>Objectives: </strong>We assessed the radiation dosages (D<sub>mean</sub>) on implant regions to identify the threshold for implant loss in patients with an intraoral malignancy treated with dental implants to support a mandibular denture during ablative surgery before volumetric-modulated arc therapy (VMAT).</p><p><strong>Materials and methods: </strong>Data was collected prospectively from 28 patients treated surgically for an intraoral malignancy, followed by postoperative radiotherapy (VMAT) and analyzed retrospectively. Patients received 2 implants in the native mandible during ablative surgery. Implant-specific D<sub>mean</sub> values were retrieved from the patients' files. Radiographic bone loss was measured 1 year after implant placement and during the last follow-up appointment. Implant survival was analyzed with the Kaplan-Meier method. Univariate logistic regression and Cox-regression analyses were performed to investigate the effect of increasing implant-specific radiation dosages on implant loss.</p><p><strong>Results: </strong>Five out of 56 placed implants were lost during follow-up (median 36.0 months, IQR 39.0). Radiographically, peri-implant bone loss occurred in implants with a D<sub>mean</sub> > 40 Gy. Implant loss occurred only in implants with a D<sub>mean</sub> > 50 Gy.</p><p><strong>Conclusion: </strong>An implant-specific D<sub>mean</sub> higher than 50 Gy is related to more peri-implant bone loss and, eventually, implant loss.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138176893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2024-01-31DOI: 10.1111/odi.14826
Jie Yang, Shurong Yang, Xuejun Ge, Lu Yuan, Yini Qi, Zhen Huang, Guan Yang, Ran Zhang
Objectives: To explore the effect of protein arginine methyltransferase 5 (PRMT5) on tooth extraction sockets healing, we established an extraction sockets model in osteoblast-conditional Prmt5 knockout mice. The results provided clues for promoting extraction sockets healing in clinical settings.
Materials and methods: Maxillary first molars were extracted from 6 to 8-week-old mice to establish an extraction fossa model. Microcomputed tomography (Micro-CT), histology, and immunostaining assays were performed on samples harvested at 3-, 7-, and 14-day post-extraction. Prmt5-silenced cell lines were employed to explore the regulatory mechanisms underlying the osteigenic differentiation.
Results: PRMT5 expression was higher in the early stage of socket healing. Micro-CT analysis showed that the percentage of new bone in the extraction sockets was lower in OC-Cre; Prmt5fl/fl mice than in the control group, consistent with Masson staining. We found that, Prmt5 deficiency delayed the osteogenesis during extraction socket healing, which might be achieved through the decrease of H4R3me2s in the Sp7 promoter region.
Conclusion: PRMT5 in osteoblasts may promote the differentiation of osteoblasts by regulating the Sp7 promoter H4R3me2s and participate in the healing of tooth extraction sockets.
{"title":"Protein arginine methyltransferase 5 in osteoblasts promotes the healing of extraction sockets.","authors":"Jie Yang, Shurong Yang, Xuejun Ge, Lu Yuan, Yini Qi, Zhen Huang, Guan Yang, Ran Zhang","doi":"10.1111/odi.14826","DOIUrl":"10.1111/odi.14826","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the effect of protein arginine methyltransferase 5 (PRMT5) on tooth extraction sockets healing, we established an extraction sockets model in osteoblast-conditional Prmt5 knockout mice. The results provided clues for promoting extraction sockets healing in clinical settings.</p><p><strong>Materials and methods: </strong>Maxillary first molars were extracted from 6 to 8-week-old mice to establish an extraction fossa model. Microcomputed tomography (Micro-CT), histology, and immunostaining assays were performed on samples harvested at 3-, 7-, and 14-day post-extraction. Prmt5-silenced cell lines were employed to explore the regulatory mechanisms underlying the osteigenic differentiation.</p><p><strong>Results: </strong>PRMT5 expression was higher in the early stage of socket healing. Micro-CT analysis showed that the percentage of new bone in the extraction sockets was lower in OC-Cre; Prmt5<sup>fl/fl</sup> mice than in the control group, consistent with Masson staining. We found that, Prmt5 deficiency delayed the osteogenesis during extraction socket healing, which might be achieved through the decrease of H4R3me2s in the Sp7 promoter region.</p><p><strong>Conclusion: </strong>PRMT5 in osteoblasts may promote the differentiation of osteoblasts by regulating the Sp7 promoter H4R3me2s and participate in the healing of tooth extraction sockets.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139651325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: A zinc-finger transcription factor family comprising specificity proteins (SPs) and Krüppel-like factor proteins (KLFs) plays an important role in dentin development and regeneration. However, a systematic regulatory network involving SPs/KLFs in odontoblast differentiation has not yet been described. This review examined the expression patterns of SP/KLF gene family members and their current known functions and mechanisms in odontoblast differentiation, and discussed prospective research directions for further exploration of mechanisms involving the SP/KLF gene family in dentin development.
Materials and methods: Relevant literature on SP/KLF gene family members and dentin development was acquired from PubMed and Web of Science.
Results: We discuss the expression patterns, functions, and related mechanisms of eight members of the SP/KLF gene family in dentin development and genetic disorders with dental problems. We also summarize current knowledge about their complementary or synergistic actions. Finally, we propose future research directions for investigating the mechanisms of dentin development.
Conclusions: The SP/KLF gene family plays a vital role in tooth development. Studying the complex complementary or synergistic interactions between SPs/KLFs is helpful for understanding the process of odontoblast differentiation. Applications of single-cell and spatial multi-omics may provide a more complete investigation of the mechanism involved in dentin development.
目的:由特异性蛋白(SPs)和克鲁珀尔样因子蛋白(KLFs)组成的锌指转录因子家族在牙本质的发育和再生中发挥着重要作用。然而,迄今为止尚未发现一个涉及 SPs/KLFs 在牙本质分化过程中的系统调控网络。本综述研究了SP/KLF基因家族成员的表达模式及其目前已知的在牙本质分化中的功能和机制,并探讨了进一步探索SP/KLF基因家族在牙本质发育中参与机制的前瞻性研究方向:从PubMed和Web of Science获取有关SP/KLF基因家族成员和牙本质发育的相关文献:结果:我们讨论了SP/KLF基因家族8个成员在牙本质发育和牙齿问题遗传疾病中的表达模式、功能和相关机制。我们还总结了目前关于其互补或协同作用的知识。最后,我们提出了研究牙本质发育机制的未来研究方向:结论:SP/KLF 基因家族在牙齿发育中发挥着重要作用。研究 SPs/KLF 之间复杂的互补或协同作用有助于了解牙本质细胞的分化过程。单细胞和空间多组学的应用可为牙本质发育的相关机制提供更全面的研究。
{"title":"Roles of SP/KLF transcription factors in odontoblast differentiation: From development to diseases.","authors":"Xuefei Wang, Kaida Sun, Zekai Xu, Zhuo Chen, Wenzhi Wu","doi":"10.1111/odi.14904","DOIUrl":"10.1111/odi.14904","url":null,"abstract":"<p><strong>Objectives: </strong>A zinc-finger transcription factor family comprising specificity proteins (SPs) and Krüppel-like factor proteins (KLFs) plays an important role in dentin development and regeneration. However, a systematic regulatory network involving SPs/KLFs in odontoblast differentiation has not yet been described. This review examined the expression patterns of SP/KLF gene family members and their current known functions and mechanisms in odontoblast differentiation, and discussed prospective research directions for further exploration of mechanisms involving the SP/KLF gene family in dentin development.</p><p><strong>Materials and methods: </strong>Relevant literature on SP/KLF gene family members and dentin development was acquired from PubMed and Web of Science.</p><p><strong>Results: </strong>We discuss the expression patterns, functions, and related mechanisms of eight members of the SP/KLF gene family in dentin development and genetic disorders with dental problems. We also summarize current knowledge about their complementary or synergistic actions. Finally, we propose future research directions for investigating the mechanisms of dentin development.</p><p><strong>Conclusions: </strong>The SP/KLF gene family plays a vital role in tooth development. Studying the complex complementary or synergistic interactions between SPs/KLFs is helpful for understanding the process of odontoblast differentiation. Applications of single-cell and spatial multi-omics may provide a more complete investigation of the mechanism involved in dentin development.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139972931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2024-01-04DOI: 10.1111/odi.14860
Joseph Katz, Eva Sayman, Hanzhi Gao
{"title":"The increased odds ratio for Bell's palsy following COVID-19 infection or vaccination.","authors":"Joseph Katz, Eva Sayman, Hanzhi Gao","doi":"10.1111/odi.14860","DOIUrl":"10.1111/odi.14860","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139098441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2024-03-19DOI: 10.1111/odi.14929
Jianwei Zhang, Zian Tong, Long Chen, Yinjie Qian, Yifan Lu, Qianming Chen, Misi Si
Objective: Peri-implantitis is one of the most common complications of implants. However, its pathogenesis has not been clarified. In recent years, mouse models are gradually being used in the study of peri-implantitis. This review aims to summarize the methods used to induce peri-implantitis in mice and their current applications.
Method: Articles of peri-implantitis mouse models were collected. We analyzed the various methods of inducing peri-implantitis and their application in different areas.
Results: Most researchers have induced peri-implantitis by silk ligatures. Some others have induced peri-implantitis by Pg gavage and LPS injection. Current applications of peri-implantitis mouse models are in the following areas: investigation of pathogenesis and exploration of new interventions, comparison of peri-implantitis with periodontitis, the interaction between systemic diseases and peri-implantitis, etc. CONCLUSION: Silk ligature for 2-4 weeks, Pg gavage for 6 weeks, and LPS injection for 6 weeks all successfully induced peri-implantitis in mice. Mice have the advantages of mature gene editing technology, low cost, and short time to induce peri-implantitis. It has applications in the study of pathogenesis, non-surgical treatments, and interactions with other diseases. However, compared with large animals, mice also have a number of disadvantages that limit their application.
{"title":"Development and applications of peri-implantitis mouse models.","authors":"Jianwei Zhang, Zian Tong, Long Chen, Yinjie Qian, Yifan Lu, Qianming Chen, Misi Si","doi":"10.1111/odi.14929","DOIUrl":"10.1111/odi.14929","url":null,"abstract":"<p><strong>Objective: </strong>Peri-implantitis is one of the most common complications of implants. However, its pathogenesis has not been clarified. In recent years, mouse models are gradually being used in the study of peri-implantitis. This review aims to summarize the methods used to induce peri-implantitis in mice and their current applications.</p><p><strong>Method: </strong>Articles of peri-implantitis mouse models were collected. We analyzed the various methods of inducing peri-implantitis and their application in different areas.</p><p><strong>Results: </strong>Most researchers have induced peri-implantitis by silk ligatures. Some others have induced peri-implantitis by Pg gavage and LPS injection. Current applications of peri-implantitis mouse models are in the following areas: investigation of pathogenesis and exploration of new interventions, comparison of peri-implantitis with periodontitis, the interaction between systemic diseases and peri-implantitis, etc. CONCLUSION: Silk ligature for 2-4 weeks, Pg gavage for 6 weeks, and LPS injection for 6 weeks all successfully induced peri-implantitis in mice. Mice have the advantages of mature gene editing technology, low cost, and short time to induce peri-implantitis. It has applications in the study of pathogenesis, non-surgical treatments, and interactions with other diseases. However, compared with large animals, mice also have a number of disadvantages that limit their application.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2024-01-08DOI: 10.1111/odi.14867
Lucas Alves da Mota Santana, Lysandro Pinto Borges, Antônio Carlos Marqueti, Bernardo Ferreira Brasileiro, Cleverson Luciano Trento
{"title":"Comment on: \"The emerging meanings of spirituality in oral medicine practice\".","authors":"Lucas Alves da Mota Santana, Lysandro Pinto Borges, Antônio Carlos Marqueti, Bernardo Ferreira Brasileiro, Cleverson Luciano Trento","doi":"10.1111/odi.14867","DOIUrl":"10.1111/odi.14867","url":null,"abstract":"","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139403917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01Epub Date: 2024-02-20DOI: 10.1111/odi.14894
Yiting Li, Pengcheng He, Liwei Zheng, Xin Zhou
Objectives: Odontogenesis, an intricate process initiated by epithelium-mesenchyme interaction, is meticulously regulated by a cascade of regulatory mechanisms. Epigenetic modifications, especially histone modification, have been found to exhibit spatiotemporal specificity during tooth development. However, the expression patterns and roles of enzymes associated with histone modifications have yet to be systematically explored in odontogenesis. This review aims to summarize the histone-modifying enzymes in odontogenesis and their regulation mechanism during tooth development and provide the potential theoretical basis for the clinical management and intervention of dental developmental diseases.
Subjects and methods: This study conducted a systematic search across PubMed and Web of Science databases, utilizing the keywords "odontogenesis," "histone modification," and "enzyme" for pertinent articles.
Results: No doubt histone modification contributes extensively to odontogenesis regulation, and the disturbances in histone modifications can derange the odontogenesis process.
Conclusion: Further studies are warranted to elucidate these roles and their potential downstream effects, positioning histone modifications as a pivotal focal point for unraveling the intricacies of tooth development and regeneration.
目的:牙齿生成是上皮细胞与间充质相互作用的一个复杂过程,受到一系列调控机制的严格调控。研究发现,表观遗传修饰,尤其是组蛋白修饰,在牙齿发育过程中表现出时空特异性。然而,与组蛋白修饰相关的酶的表达模式和作用在牙体发生过程中还有待系统探讨。本综述旨在总结牙体发生过程中组蛋白修饰酶及其调控机制,为牙齿发育疾病的临床治疗和干预提供潜在的理论依据:本研究利用 "牙体发生"、"组蛋白修饰 "和 "酶 "等关键词在PubMed和Web of Science数据库中对相关文章进行了系统检索:结果:毫无疑问,组蛋白修饰在牙体发生的调控中起着广泛的作用,而组蛋白修饰的紊乱会破坏牙体发生的过程:结论:有必要开展进一步研究,以阐明组蛋白的这些作用及其潜在的下游效应,并将组蛋白修饰定位为揭示牙齿发育和再生复杂性的关键焦点。
{"title":"Histone-modifying enzymes: Roles in odontogenesis and beyond.","authors":"Yiting Li, Pengcheng He, Liwei Zheng, Xin Zhou","doi":"10.1111/odi.14894","DOIUrl":"10.1111/odi.14894","url":null,"abstract":"<p><strong>Objectives: </strong>Odontogenesis, an intricate process initiated by epithelium-mesenchyme interaction, is meticulously regulated by a cascade of regulatory mechanisms. Epigenetic modifications, especially histone modification, have been found to exhibit spatiotemporal specificity during tooth development. However, the expression patterns and roles of enzymes associated with histone modifications have yet to be systematically explored in odontogenesis. This review aims to summarize the histone-modifying enzymes in odontogenesis and their regulation mechanism during tooth development and provide the potential theoretical basis for the clinical management and intervention of dental developmental diseases.</p><p><strong>Subjects and methods: </strong>This study conducted a systematic search across PubMed and Web of Science databases, utilizing the keywords \"odontogenesis,\" \"histone modification,\" and \"enzyme\" for pertinent articles.</p><p><strong>Results: </strong>No doubt histone modification contributes extensively to odontogenesis regulation, and the disturbances in histone modifications can derange the odontogenesis process.</p><p><strong>Conclusion: </strong>Further studies are warranted to elucidate these roles and their potential downstream effects, positioning histone modifications as a pivotal focal point for unraveling the intricacies of tooth development and regeneration.</p>","PeriodicalId":19615,"journal":{"name":"Oral diseases","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}