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OWE-1 Investigation of the metabolome and mycobiome in Parkinson’s disease 帕金森病代谢组和真菌组的we -1研究
Pub Date : 2021-11-01 DOI: 10.1136/gutjnl-2021-bsg.32
G. Gebeyehu, L. Flain, Rachael Slater, A. Frau, C. Probert, U. Ijaz, E. Pablo-Fernández, T. Warner
two groups of solid phase micro-extraction gas chromatography mass spectrometry. DNA was extracted from a subset of 24 PD and 20 control samples: 18S rRNA gene amplicons were prepared and sequenced using an Illumina MiSeq plat-form. Metabolomics and mycobiome statistical analysis were carried out using Metaboanalyst and R respectively. The R package mixOmics was used for integrated omics analysis in this subset.
两组固相微萃取气相色谱质谱法。从24个PD样本和20个对照样本中提取DNA,制备18S rRNA基因扩增子,并使用Illumina MiSeq平台进行测序。代谢组学和真菌组学统计分析分别使用Metaboanalyst和R进行。使用R包mixOmics对该子集进行综合组学分析。
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引用次数: 0
OTH-3 The state of the gastroenterology and hepatology consultant workforce in 2020 OTH-3 2020年胃肠病学和肝病学顾问队伍状况
Pub Date : 2021-11-01 DOI: 10.1136/gutjnl-2021-bsg.34
Charlotte E Rutter, C. Phillips, Darin Nagamootoo, Simon O’Hare, N. Newbery, N. Trudgill
IntroductionBritish Society of Gastroenterology (BSG) Workforce reports have identified widespread consultant vacancies, excessive workloads and insufficient training posts to meet current and future service demand. The COVID-19 pandemic has put further strain on an already overstretched and often demoralised workforce.MethodsThe Medical Workforce Unit of the Royal College of Physicians (RCP) undertakes an annual census of consultants each October. Data for gastroenterologists and hepatologists from the 2019 census, January 2020 RCP consultant wellbeing survey and the General Medicine Council (GMC) between 2012 and 2020 were examined.ResultsThe number of UK licensed gastroenterologists increased from 1,703 to 2,013 from 2014 to 2019. However, in recent years, fewer gastroenterologists have joined the GMC register annually (151 in 2014 and 115 in 2018). Consequently, 45% of advertised consultant posts in gastroenterology were unfilled and 8% of all posts filled by a locum in 2019, mostly due to a lack of applicants, with demand outstripping supply. There has also been a smaller increase (9% versus 14%) in gastroenterology trainee numbers compared to other medical specialties between 2012 and 2020. The average number of population per full time equivalent gastroenterologist in the UK is 43,913 but there are significant regional variations with some regions much more poorly served (Thames Valley 63,456, North Wales 59,444, Kent, Surrey and Sussex 50.974, and East of England 50,487).Gastroenterologists work a mean of 1PA unpaid in addition to contracted PAs. This leads to gastroenterologists saying they always, or most of the time in 59% work excessive hours and in 61% have an excessive workload. Gastroenterology is the major specialty at highest risk of burnout with lower (worse) mean mental wellbeing scores. Consequently, 51% of gastroenterologists reported that work affected their relationship with their partner and 53% with their children in the past year. 52% described their morale in 2019 as being worse than in 2018. 18% of gastroenterologists reported feeling bullied or harassment over the past year by managers or fellow consultants. Despite these issues, 87% of gastroenterologists reported they were always or often satisfied with specialty work, but only 21% with general internal medicine work.ConclusionsUnfilled consultant vacancies, high workloads, low wellbeing scores and morale were evident in gastroenterology and hepatology even before the COVID-19 pandemic. Gastroenterology is the major medical specialty at highest risk of burnout. At a time when the NHS workforce is under increasing pressure, these issues must be urgently addressed to improve the working lives of gastroenterologists and hepatologists.
英国胃肠病学会(BSG)劳动力报告已经确定了广泛的顾问空缺,过度的工作量和培训岗位不足,以满足当前和未来的服务需求。2019冠状病毒病大流行给本已过度紧张且往往士气低落的劳动力带来了进一步的压力。方法英国皇家医师学院(RCP)医疗人力单位每年10月对会诊医师进行一次年度普查。研究人员检查了2019年人口普查、2020年1月RCP顾问健康调查和2012年至2020年通用医学委员会(GMC)的胃肠病学家和肝病学家的数据。结果从2014年到2019年,英国持牌胃肠病学家的数量从1703人增加到2013人。然而,近年来,每年加入GMC注册的胃肠病学家越来越少(2014年为151人,2018年为115人)。因此,2019年,45%的胃肠病学顾问职位空缺,8%的职位由临时医生填补,主要原因是缺乏申请者,供不应求。2012年至2020年间,与其他医学专业相比,胃肠病学实习人数的增幅也较小(9%对14%)。在英国,每名全职胃肠病学家的平均人数为43,913人,但存在显著的地区差异,一些地区的服务水平要差得多(泰晤士河谷63,456人,北威尔士59,444人,肯特,萨里和苏塞克斯50.974人,英格兰东部50,487人)。除了签约的私人助理外,胃肠病学家的平均年薪为无薪1PA。这导致胃肠病学家说,他们总是,或者大多数时候,59%的人工作时间过长,61%的人工作量过大。胃肠病学是职业倦怠风险最高的专业,平均心理健康得分较低(更差)。因此,51%的胃肠病学家报告说,在过去的一年里,工作影响了他们与伴侣的关系,53%的人影响了他们与孩子的关系。52%的人表示,他们2019年的士气比2018年更差。18%的胃肠病学家报告称,在过去的一年里,他们曾受到管理人员或顾问同事的欺凌或骚扰。尽管存在这些问题,87%的胃肠病学家报告说他们总是或经常对专业工作感到满意,但只有21%的人对普通内科工作感到满意。结论早在2019冠状病毒病大流行之前,胃肠病学和肝脏病学就存在顾问空缺不足、工作量大、幸福感低和士气低落的现象。胃肠病学是职业倦怠风险最高的主要医学专业。当NHS的工作人员面临越来越大的压力时,这些问题必须紧急解决,以改善胃肠病学家和肝病学家的工作生活。
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引用次数: 0
OFR-10 Admission model for intensification of therapy in acute severe colitis (ADMIT-ASC) OFR-10急性严重结肠炎强化治疗入院模型(ADMIT-ASC)
Pub Date : 2021-11-01 DOI: 10.1136/gutjnl-2021-bsg.7
A. Adams, Vipin Gupta, W. Mohsen, T. Chapman, D. Subhaharan, P. Ramaswamy, V. Ahuja, S. Travis, J. Satsangi
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引用次数: 0
OTU-14 Colonoscopy polyp detection is lower at weekends: A national endoscopy database analysis OTU-14结肠镜息肉检出率在周末较低:国家内窥镜数据库分析
Pub Date : 2021-11-01 DOI: 10.1136/gutjnl-2021-bsg.4
Liya Lu, J. Catlow, R. Broughton, P. Rogers, L. Sharp, M. Rutter
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引用次数: 1
OTH-11 Biliary complications on home parenteral nutrition: Experience of a regional referral centre for intestinal failure 家庭肠外营养的胆道并发症:一个地区肠衰竭转诊中心的经验
Pub Date : 2021-11-01 DOI: 10.1136/gutjnl-2021-bsg.28
S. Esmaily, L. Gemmell, H. Leyland, N. Thompson, J. Leeds, C. Mountford
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引用次数: 0
OFR-1 Young persons and health care professionals experience of virtual gastroenterology consultations – a multicentre survey OFR-1年轻人和卫生保健专业人员的虚拟胃肠病学咨询经验-一项多中心调查
Pub Date : 2021-11-01 DOI: 10.1136/gutjnl-2021-bsg.33
R. Hubbard, N. Arebi, A. Brooks, Sara El-Kouli, F. Kiparissi, E. Mozdiak, Philip Smith, N. Zarate-Lopez, V. Garrick, P. Narula
OFR-1 Table 1Key findings YP HCP VC strengths Saved time 84% Saved money 78% Reduced travel 25% Improved access to healthcare 81% Useful appointment 87% Would like VC again 83% More efficient & convenient Don’t miss education/work Safer during COVID Spoke to YP directly 80% Saw more patients 23% More free admin time 23% Convenient Don’t always need clinic room VC barriers Poor WIFI Need extra appointment for investigations/to collect prescriptions Communication easier face to face Less private Patient had to come to hospital for tests post VC 77% Unable to speak to YP privately 69% Unable to contact patient 48% Information technology (I.T) problems 29% Difficulty arranging investigations 23% Suggested improvements Improve I.T Use video not phone Prefer face to face Improve I.T 86% Have YP present for VC Ability to speak to YP alone Having results ready and easily accessible Improved pathways for requesting tests ConclusionsOverall respondents were satisfied with VC and felt they were useful, convenient and saved time.The surveys highlighted that improved I.T for both staff and patients is vital. In addition, improved processes for requesting investigations, prescriptions and accessing results would minimise admin time for staff and extra appointments for patients.Direct engagement and privacy with YP was reported to be more difficult with VC, which is an important consideration in developmentally appropriate transitional healthcare. Some YP felt more comfortable discussing personal or complex issues face to face with a HCP that they knew.It is important to recognise patient preference for face to face or virtual clinics and personalise care accordingly, acknowledging that this may alter with time and circumstance.Successful virtual consultations rely on appropriate patient selection and availability of reliable WIFI and IT. Patient preference is key and this may alter with time.
OFR-1表1重要发现YP HCP VC优势节省时间84%省钱78%减少旅行25%改善医疗条件81%有用任命87%又想VC 83%更高效和方便不要错过教育/工作期间安全COVID说话直接YP 80%看到更多的病人23%更多的自由时间管理23%方便并不总是需要诊所房间VC壁垒可怜的WIFI需要额外的任命调查/收集处方面对面交流更容易更少的私人病人来医院做测试后VC 77%不能说话私下YP 69%无法接触病人48%信息技术(信息技术)问题29%安排调查困难不是23%建议改进提高电脑使用视频电话会更喜欢面对面的提高电脑86% YP给VC YP单独说话能力有准备和容易改进途径要求测试结果ConclusionsOverall受访者满意VC,感觉他们实用、方便、省时。调查强调,改善员工和患者的信息技术至关重要。此外,要求检查、处方和获取结果的流程得到改进,将最大限度地减少工作人员的管理时间,并减少患者的额外预约。据报道,VC与YP的直接接触和隐私更困难,这是与发展相适应的过渡医疗保健的重要考虑因素。有些YP更愿意与他们认识的HCP面对面地讨论个人或复杂的问题。重要的是要认识到患者对面对面或虚拟诊所的偏好,并相应地进行个性化护理,承认这可能会随着时间和环境而改变。成功的虚拟会诊依赖于适当的患者选择和可靠的WIFI和IT的可用性。患者的偏好是关键,这可能会随着时间的推移而改变。
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引用次数: 0
OTU-15 BSG trainees section survey 2020 – the impact of COVID-19 on UK gastroenterology training 2020年OTU-15 BSG学员部分调查- COVID-19对英国胃肠病学培训的影响
Pub Date : 2021-11-01 DOI: 10.1136/gutjnl-2021-bsg.37
Elizabeth Ratcliffe, Rebecca Harris, S. Raju, C. Cook, Philip D. Harvey
IntroductionThe impact of the COVID-19 pandemic has disrupted training during the initial peak and partial recovery. Gastroenterology higher speciality training (HST) is reaching an inflection point with a reduction from five years to four. The potential compound impact is a source of concern for HSTs. The BSG Trainees Section biennial survey 2020 aimed to delineate the impact of COVID-19 and opinions on changes to training.MethodsAn electronic survey allowing for anonymised responses at the point of completion was distributed to all gastroenterology HSTs over a three month period from September to November 2020.ResultsIn total, 349 trainees completed the survey (response rate of 51% of 687 HSTs) with representation across all regions. 89%(307/344) of responders were full time trainees and 39%(136/349) female. There was a reduction in access to clinics;48.4%(169/349) reported due to general internal medicine (GIM) duties and 26.6% (93/349) due to reduction in available clinics. Reduction in experience in gastroenterology referrals were also mainly limited by GIM commitments (42.4%) (148/349). No endoscopy training occurred for 88.5(170/192)% of trainees at the peak. Recovery of training lists was reported by 67.3(175/260)% of responders in late summer yet 20.6(72/349)% reported training lists were still ‘not allowed’ in their trust. 71.0 (206/290)% of responders reported their time was predominantly taken by GIM, with 42.1 (110/261)% considering the need to extend their CCT date to compensate for this. 49.0%(128/261) of respondents were considering time out of programme or fellowships and 28.3 (74/261)% considering it in the future. The majority of responders reported virtual or online teaching was provided during the peak of the pandemic.Considering future training;96.8%(245/253) of respondents stated gastroenterology HSTs should have 1 year experience on a GI bleed rota, however only 21.3 (55/258)% reported having experience of this formally during training. 68.8%(174/253) of responders supported the idea of blocks of GIM training during HST to protect gastroenterology training. The majority of trainees (84.2%)(213/253) reported they would not feel ready to be a consultant after 4 years of HST. 46.7(122/261)% of responders would stop GIM training if given the opportunity.ConclusionsIn all aspects of gastroenterology training surveyed, more than half of training time was lost during the pandemic. This included training beyond endoscopy to other aspects of GI work including clinics and referrals. This is mirrored in anticipated concerns about completion of training and the perceived future competence as a consultant at the end of a 4 year higher training programme. Work is now required to ensure training trajectories are restored following the COVID-19 pandemic.
2019冠状病毒病大流行的影响扰乱了最初高峰和部分恢复期间的培训。胃肠病学高等专科培训(HST)正达到一个拐点,从五年减少到四年。潜在的综合影响是高强度sts关注的一个来源。BSG培训科2020年两年期调查旨在描述2019冠状病毒病的影响以及对培训改革的意见。方法在2020年9月至11月的三个月期间,向所有胃肠病学hst分发了一份允许在完成时匿名回答的电子调查。结果共有349名学员完成了调查(687名hst的回复率为51%),来自所有地区。89%(307/344)的应答者为全日制受训人员,39%(136/349)为女性。到诊所就诊的人数减少;据报告,48.4%(169/349)是由于普通内科(GIM)的职责,26.6%(93/349)是由于可用诊所的减少。胃肠病学转诊经验的减少也主要受到GIM承诺的限制(42.4%)(148/349)。88.5(170/192)%的受训者在高峰期未接受内窥镜检查训练。在夏末,67.3(175/260)%的应答者报告了培训清单的恢复,但20.6(72/349)%的应答者报告他们信任的培训清单仍然“不允许”。71.0(206/290)%的应答者报告他们的时间主要被GIM占用,42.1(110/261)%的应答者认为需要延长他们的CCT日期以弥补这一点。49.0%(128/261)的受访者正在考虑计划或研究金之外的时间,28.3%(74/261)的受访者正在考虑未来。大多数应答者报告说,在大流行高峰期提供了虚拟或在线教学。考虑到未来的培训,96.8%(245/253)的受访者表示胃肠病学HSTs应该有1年的胃肠道出血轮值经验,然而只有21.3(55/258)%的受访者报告在培训期间有正式的这方面的经验。68.8%(174/253)的应答者支持在HST期间阻断GIM培训以保护胃肠病学培训的想法。大多数受训人员(84.2%)(213/253)表示,在完成了4年的HST培训后,他们觉得自己还没有准备好成为一名咨询师。如果有机会,46.7%(122/261)的应答者会停止GIM培训。结论在调查的胃肠病学培训的各个方面中,大流行期间浪费了一半以上的培训时间。这包括内窥镜以外的胃肠道工作的其他方面的培训,包括诊所和转诊。这反映在预期的对培训完成情况的关注和在四年高等培训方案结束时作为顾问的未来能力的关注上。现在需要努力确保在2019冠状病毒病大流行之后恢复培训轨迹。
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引用次数: 1
OMO-2 Filgotinib efficacy in patients with ulcerative colitis by line of therapy: Phase 2b/3 selection results OMO-2非戈替尼对溃疡性结肠炎患者的疗效:2b/3期选择结果
Pub Date : 2021-11-01 DOI: 10.1136/gutjnl-2021-bsg.9
Ben Morison, L. Peyrin-Biroulet, I. Dotan, T. Hibi, V. Taliadouros, A. Oortwijn, Sally Zhao, J Zhang, J. Hsieh, B. Feagan
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引用次数: 0
OTH-8 Patient reported anxiety, before and after colonoscopy, during the COVID-19 pandemic OTH-8患者在COVID-19大流行期间结肠镜检查前后报告焦虑
Pub Date : 2021-11-01 DOI: 10.1136/gutjnl-2021-bsg.36
A. Prentice, Ghalia Kayal, S. Marshall, C. Wagner, R. Kerrison
IntroductionAt the start of the covid-19 pandemic, many invasive diagnostic tests had to be stopped to avoid patients catching covid-19 as a result of attending hospital. Several procedures to reduce COVID transmission have been implemented as services resumed (e.g. COVID testing). Despite this, some patients may still experience what is now called ‘COVID anxiety’. The aim of this study was to monitor satisfaction with covid mitigation measures and anxiety among patients attending colonoscopy following an abnormal screening result.MethodsWe surveyed patients who were invited for colonoscopy at St Mark’s Hospital between July 2020 and May 2021. Data on anxiety and worry were collected, 3 days before and after colonoscopy;scales ranged from 6-24 for general anxiety, 0-20 for COVID-anxiety and 1-4 for bowel cancer worry (with higher scores representing greater anxiety for all three measures). Descriptive statistics were used to assess mean pre- and post-procedure anxiety scores. Inferential statistics were used to test for differences in anxiety, before and after colonoscopy. All analyses were performed using SPSS (Ver 27.0).Results205 patients (mean age 67 years;114 males, 91 females;121 White, 55, South Asian, 27 any other ethnicity;142 English first language speakers) completed the pre-procedure questionnaire and were enrolled into the study. 89 (43.4%) completed the post-procedure questionnaire and were analysed.Pre- procedure, mean general anxiety, COVID-anxiety, and bowel cancer worry scores were 10.94, 0.93 and 1.95, respectively. Post-procedure, the general anxiety, COVID-anxiety and bowel cancer worry scores were 8.92, 1.03 and 2.11, respectively. The change in general anxiety (-2.02) was statistically significant (p=0.015), while the changes in COVID anxiety (+0.1) and bowel cancer worry (+0.16) were not (both ps<0.05).Significant reductions in general anxiety were observed for women (pre- and post-procedure general anxiety scores were: 13.05 vs. 8.33, respectively;p<0.001), White British adults (pre- and post-procedure general anxiety scores were: 11.47 and 8.90, respectively;p<0.001) and adults whose first language was English (pre- and post-procedure general anxiety scores were: 11.49 and 9.08, respectively;p<0.001).The majority of patients were highly satisfied with the covid-measures put in place. There was no association between satisfaction and changes in COVID Anxiety (p<0.05).ConclusionsCOVID anxiety was low among people who attended colonoscopy. General anxiety, however, was moderate, although it was reduced following the procedure. General anxiety was not reduced for some groups, including those whose first language is not English, highlighting the need for further research into factors affecting experience in these groups.
在covid-19大流行开始时,必须停止许多侵入性诊断测试,以避免患者因住院而感染covid-19。随着业务恢复,已经实施了一些减少COVID传播的程序(例如COVID检测)。尽管如此,一些患者可能仍然会经历现在所谓的“COVID焦虑”。本研究的目的是监测筛查结果异常后参加结肠镜检查的患者对covid缓解措施的满意度和焦虑。方法:我们调查了2020年7月至2021年5月期间在圣马可医院接受结肠镜检查的患者。在结肠镜检查前后3天收集焦虑和担忧的数据;一般焦虑的评分范围为6-24,covid - 19焦虑的评分范围为0-20,肠癌担忧的评分范围为1-4(得分越高,这三项指标的焦虑程度越高)。描述性统计用于评估手术前后的平均焦虑评分。采用推理统计来检验结肠镜检查前后焦虑的差异。所有分析均使用SPSS (Ver 27.0)进行。结果205例患者(平均年龄67岁,男性114例,女性91例;白人121例,南亚裔55例,其他种族27例;142例以英语为母语者)完成了术前问卷调查并纳入研究。89例(43.4%)完成术后问卷调查并进行分析。术前、一般焦虑、新冠焦虑和肠癌焦虑的平均得分分别为10.94、0.93和1.95。术后一般焦虑、新冠焦虑和肠癌焦虑得分分别为8.92、1.03和2.11。一般焦虑(-2.02)变化有统计学意义(p=0.015),而COVID焦虑(+0.1)和肠癌焦虑(+0.16)变化无统计学意义(p均<0.05)。女性(手术前和手术后的一般焦虑评分分别为:13.05和8.33,p<0.001)、英国白人成年人(手术前和手术后的一般焦虑评分分别为:11.47和8.90,p<0.001)和母语为英语的成年人(手术前和手术后的一般焦虑评分分别为:11.49和9.08,p<0.001)的一般焦虑显著降低。大多数患者对采取的抗疫措施非常满意。满意度与新冠焦虑变化无相关性(p<0.05)。结论参加结肠镜检查的患者的scovid焦虑水平较低。然而,总体焦虑是中度的,尽管在手术后有所减少。对于一些群体,包括那些母语不是英语的人来说,总体焦虑并没有减少,这凸显了对影响这些群体体验的因素进行进一步研究的必要性。
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引用次数: 0
OWE-5 Carvedilol vs. endoscopic band ligation for variceal bleeding secondary prophylaxis; long-term RCT follow-up oe -5卡维地洛与内窥镜绑扎治疗静脉曲张出血二级预防的比较长期随机对照试验随访
Pub Date : 2021-11-01 DOI: 10.1136/gutjnl-2021-bsg.17
P. Dunne, P. Hayes, D. Tripathi, J. Leithead, L. Smith, D. Gaya, E. Forrest, A. Stanley
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引用次数: 0
期刊
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
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