Pub Date : 2025-12-17DOI: 10.1016/j.joca.2025.12.012
Rana S Hinman, Rachel K Nelligan, Penny K Campbell, Peixuan Li MBiostat, Karen E Lamb, Sarah Stratulate, Alexander J Kimp, Yee Foong Mok, Bridget Graham, Mark Merolli, Kim L Bennell
{"title":"Mobile app to support home exercise adherence in knee osteoarthritis: a randomized clinical trial","authors":"Rana S Hinman, Rachel K Nelligan, Penny K Campbell, Peixuan Li MBiostat, Karen E Lamb, Sarah Stratulate, Alexander J Kimp, Yee Foong Mok, Bridget Graham, Mark Merolli, Kim L Bennell","doi":"10.1016/j.joca.2025.12.012","DOIUrl":"https://doi.org/10.1016/j.joca.2025.12.012","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"66 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-17DOI: 10.1016/j.joca.2025.12.013
Fatma Scerif, Suzanne E. Eldridge
{"title":"Osteoarthritis year in review 2025: Biology","authors":"Fatma Scerif, Suzanne E. Eldridge","doi":"10.1016/j.joca.2025.12.013","DOIUrl":"https://doi.org/10.1016/j.joca.2025.12.013","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"172 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-16DOI: 10.1016/j.joca.2025.12.008
Zheng Zhou,Ziyi Ren,Hao Sun,Fan Yang,Xiyang Liu,Xin Zhang,Yongzhi Li,Hongjie Huang,Jianquan Wang
OBJECTIVETo quantitatively analyze the effects of long-term simulated bed rest unloading on knee articular cartilage using quantitative magnetic resonance imaging (fMRI), alongside functional and subjective outcomes.METHODSIn this prospective cohort study, 23 healthy men (mean age 32.7 ± 5.2 years) completed a 60-day, -6° head-down bed rest (HDBR) protocol. The primary endpoints, knee cartilage T2 relaxation time and thickness, were assessed using a 3.0T MRI system before and after HDBR. Data were analyzed with linear mixed-effects models. Secondary outcomes included isokinetic muscle strength, thigh circumference, dynamic balance (Y-Balance Test), and patient-reported outcomes (International Knee Documentation Committee score, Lysholm Knee Score, Self-rating Anxiety Scale, and Self-rating Depression Scale).RESULTSHDBR induced a decrease in the knee-averaged cartilage T2 relaxation time (mean change, -0.67 ms; 95% CI, -1.22 to -0.11; p = 0.018). In contrast, no clear effect on cartilage thickness was observed (mean change, -0.054 mm; 95% CI, -0.159 to 0.050; p = 0.307). Functional and subjective outcomes indicated declines in muscle performance and functional scores.CONCLUSIONS60 days of simulated microgravity led to a decrease in knee cartilage T2 relaxation time without changes in thickness, suggesting early matrix alterations. These findings, together with observed neuromuscular deficits, highlight the need for protective strategies during prolonged unloading.
{"title":"Quantitative MRI Assessment of Knee Cartilage Alterations Following 60-Day Head-Down Bed Rest.","authors":"Zheng Zhou,Ziyi Ren,Hao Sun,Fan Yang,Xiyang Liu,Xin Zhang,Yongzhi Li,Hongjie Huang,Jianquan Wang","doi":"10.1016/j.joca.2025.12.008","DOIUrl":"https://doi.org/10.1016/j.joca.2025.12.008","url":null,"abstract":"OBJECTIVETo quantitatively analyze the effects of long-term simulated bed rest unloading on knee articular cartilage using quantitative magnetic resonance imaging (fMRI), alongside functional and subjective outcomes.METHODSIn this prospective cohort study, 23 healthy men (mean age 32.7 ± 5.2 years) completed a 60-day, -6° head-down bed rest (HDBR) protocol. The primary endpoints, knee cartilage T2 relaxation time and thickness, were assessed using a 3.0T MRI system before and after HDBR. Data were analyzed with linear mixed-effects models. Secondary outcomes included isokinetic muscle strength, thigh circumference, dynamic balance (Y-Balance Test), and patient-reported outcomes (International Knee Documentation Committee score, Lysholm Knee Score, Self-rating Anxiety Scale, and Self-rating Depression Scale).RESULTSHDBR induced a decrease in the knee-averaged cartilage T2 relaxation time (mean change, -0.67 ms; 95% CI, -1.22 to -0.11; p = 0.018). In contrast, no clear effect on cartilage thickness was observed (mean change, -0.054 mm; 95% CI, -0.159 to 0.050; p = 0.307). Functional and subjective outcomes indicated declines in muscle performance and functional scores.CONCLUSIONS60 days of simulated microgravity led to a decrease in knee cartilage T2 relaxation time without changes in thickness, suggesting early matrix alterations. These findings, together with observed neuromuscular deficits, highlight the need for protective strategies during prolonged unloading.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"91 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145777466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-12DOI: 10.1016/j.joca.2025.12.006
Netanja I. Harlianto, Jukka Hirvasniemi, Dirk H.J. Poot, Stefan Klein, Sita M.A. Bierma-Zeinstra, Dieuwke Schiphof, Edwin H.G. Oei
{"title":"Reply to the letter to the editor concerning: T2 mapping of the articular cartilage as a biomarker for knee osteoarthritis: an analysis of the population-based Rotterdam Study","authors":"Netanja I. Harlianto, Jukka Hirvasniemi, Dirk H.J. Poot, Stefan Klein, Sita M.A. Bierma-Zeinstra, Dieuwke Schiphof, Edwin H.G. Oei","doi":"10.1016/j.joca.2025.12.006","DOIUrl":"https://doi.org/10.1016/j.joca.2025.12.006","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"145 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145730735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-12DOI: 10.1016/j.joca.2025.12.005
Matthew S. Harkey, Harvi F. Hart, Christopher Kuenze, Grace Lo, Virginia B. Kraus, Constance R. Chu, Jeffrey B. Driban
{"title":"Preventing osteoarthritis after anterior cruciate ligament injury: the case for targeting pre-osteoarthritis illness","authors":"Matthew S. Harkey, Harvi F. Hart, Christopher Kuenze, Grace Lo, Virginia B. Kraus, Constance R. Chu, Jeffrey B. Driban","doi":"10.1016/j.joca.2025.12.005","DOIUrl":"https://doi.org/10.1016/j.joca.2025.12.005","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"10 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145730736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1016/j.joca.2025.12.004
Travis Haber, Kim Bennell, Harrison Hansford, James McAuley, Peter Button, Katrina Hunt, Peixuan Li, Anurika De Silva, Jesse Pardo, Sarah Statulate, Ben Metcalf, Rana S Hinman
{"title":"The smallest worthwhile effects of strengthening exercise on pain intensity for people with knee osteoarthritis: a benefit-harm trade-off study","authors":"Travis Haber, Kim Bennell, Harrison Hansford, James McAuley, Peter Button, Katrina Hunt, Peixuan Li, Anurika De Silva, Jesse Pardo, Sarah Statulate, Ben Metcalf, Rana S Hinman","doi":"10.1016/j.joca.2025.12.004","DOIUrl":"https://doi.org/10.1016/j.joca.2025.12.004","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"6 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145730737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1016/j.joca.2025.12.007
Kirsten Seagers, Julie A. Kolesar, Valentina Mazzoli, Eni Halilaj, Scott L. Delp, Scott D. Uhlrich
{"title":"Immediate reductions in compressive and shear forces in the knee from gait retraining are associated with slowed cartilage degeneration after 1 year in medial knee osteoarthritis: A retrospective observational cohort study","authors":"Kirsten Seagers, Julie A. Kolesar, Valentina Mazzoli, Eni Halilaj, Scott L. Delp, Scott D. Uhlrich","doi":"10.1016/j.joca.2025.12.007","DOIUrl":"https://doi.org/10.1016/j.joca.2025.12.007","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"4 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145731946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-08DOI: 10.1016/j.joca.2025.12.001
Zsuzsa Jenei-Lanzl, Susanne Grässel, Hans-Georg Schaible, Rainer H. Straub
The role of the sympathetic and sensory nervous systems in the development and progression of osteoarthritis (OA) is widely recognized, as is the fact that these systems can influence each other. However, the nature of sympathosensory interactions during OA progression remains unclear. In this narrative review, we provide an overview of scientifically proven or putative sympathosensory interactions at the peripheral, spinal, and central levels. We highlight the factors that determine direct or indirect coupling types and describe the signaling and cross-signaling mechanisms of interaction at these different peripheral and central levels. Additionally, we discuss the clinical relevance of possible sympathosensory interactions in OA by introducing a new biopsychosocial OA model emphasizing the vicious cycle of chronic local and systemic inflammation, chronic pain, sleep deprivation, and chronic stress. These interrelated processes also underlie and contribute to common comorbidities such as hypertension and obesity and are unified by a state of autonomic imbalance marked by sympathetic dominance.
{"title":"Sympathosensory interactions – possible relevance in osteoarthritis","authors":"Zsuzsa Jenei-Lanzl, Susanne Grässel, Hans-Georg Schaible, Rainer H. Straub","doi":"10.1016/j.joca.2025.12.001","DOIUrl":"https://doi.org/10.1016/j.joca.2025.12.001","url":null,"abstract":"The role of the sympathetic and sensory nervous systems in the development and progression of osteoarthritis (OA) is widely recognized, as is the fact that these systems can influence each other. However, the nature of sympathosensory interactions during OA progression remains unclear. In this narrative review, we provide an overview of scientifically proven or putative sympathosensory interactions at the peripheral, spinal, and central levels. We highlight the factors that determine direct or indirect coupling types and describe the signaling and cross-signaling mechanisms of interaction at these different peripheral and central levels. Additionally, we discuss the clinical relevance of possible sympathosensory interactions in OA by introducing a new biopsychosocial OA model emphasizing the vicious cycle of chronic local and systemic inflammation, chronic pain, sleep deprivation, and chronic stress. These interrelated processes also underlie and contribute to common comorbidities such as hypertension and obesity and are unified by a state of autonomic imbalance marked by sympathetic dominance.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"5 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145705014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-06DOI: 10.1016/j.joca.2025.12.003
Karin Magnusson, Aleksandra Turkiewicz, Jaanika Paemre, Armaghan Mahmoudian, Martin Englund
{"title":"Observations of Early Structural Changes over 6 Years on Magnetic Resonance Imaging in Knees without Radiographic Osteoarthritis","authors":"Karin Magnusson, Aleksandra Turkiewicz, Jaanika Paemre, Armaghan Mahmoudian, Martin Englund","doi":"10.1016/j.joca.2025.12.003","DOIUrl":"https://doi.org/10.1016/j.joca.2025.12.003","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"1 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145689319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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