Osteoarthritis and Cartilage最新文献

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Response to the Letter to the Editor: Effects of pre- and postsurgery physical activity interventions on physical activity and sedentary behavior levels following knee and hip arthroplasty: A systematic review and meta-analysis of randomized controlled trials 给编辑的回复：术前和术后体育活动干预对膝关节和髋关节置换术后体育活动和久坐行为水平的影响：随机对照试验的系统回顾和荟萃分析

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.10.013

Noah d’Unienville, Bethany Gower, Ben Singh, Kimberley Szeto, Heather Badger, Matilda Krywanio, Carol Maher , Dominic Thewlis

引用次数: 0

Imeglimin, a novel antidiabetic agent related to metformin, attenuates knee osteoarthritis development and progression through AMPK activation and NF-κB signaling inhibition 依米明是一种由二甲双胍合成的新型降糖药物，通过激活AMPK和抑制NF-κB信号传导来减轻膝关节骨性关节炎的发生和进展

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.11.007

Yuki Hyodo , Yukio Akasaki , Ichiro Kurakazu , Masanari Kuwahara , Taisuke Uchida , Ryota Hirose , Mamiko Sakai , Takumi Kita , Koki Kato , Yasuharu Nakashima

Objective

Metformin, a first-line treatment for type 2 diabetes, attenuates hallmarks of aging and protects against age-related diseases, including osteoarthritis (OA). Here, we assessed the effects of imeglimin, a novel antidiabetic agent related to metformin, on the development and progression of knee OA.

Design

Primary human OA chondrocytes, synovial cells, and meniscal cells were stimulated with IL-1β and treated with imeglimin (n = 8). OA-related gene and protein expressions were quantified using RT-qPCR and ELISA. Activation of NF-κB and AMP-activated protein kinase (AMPK), a master regulator of energy metabolism, was assessed using western blotting and immunofluorescence. Additionally, we evaluated its efficacy in two knee OA mouse models (n = 10): destabilization of the medial meniscus and medial collateral ligament transection (DMM+MCLT), and monoiodoacetate (MIA)-induced OA pain.

Results

Imeglimin suppressed IL-1β-induced expressions of OA-related genes, including pro-inflammatory (IL6, IL1B, TNF), catabolic (MMP13, ADAMTS5), and pain-related (CCL2, NGF) genes, and reduced IL6 secretion. Western blot analysis revealed downregulation of IκBα and p65 activation and AMPK upregulation. Immunocytochemistry confirmed decreased p65 nuclear translocation (-4245 AU; 95% CI −6765 to −1725). Intra-articular administration of imeglimin reduced histological severity of OA in cartilage, synovium, and meniscus in DMM+MCLT mice (OARSI grade, −3.0 [95% CI: −5.0 to −1.0]), decreased the number of cells expressing p-IκBα in the articular cartilage, and attenuated OA pain in both DMM+MCLT and MIA models.

Conclusions

Imeglimin enhances protective functions in joint tissue cells and alleviates experimental OA in preclinical mouse models, supporting its potential as a therapeutic candidate for knee OA.

目的：甲双胍是2型糖尿病的一线治疗药物，它可以减轻衰老的标志，并预防与年龄相关的疾病，包括骨关节炎（OA）。在这里，我们评估了一种与二甲双胍相关的新型降糖药伊米明对膝关节OA发生和进展的影响。设计：用IL-1β刺激原代人OA软骨细胞、滑膜细胞和半月板细胞，并用伊米霉素处理（n = 8）。采用RT-qPCR和ELISA检测oa相关基因及蛋白的表达。采用western blotting和免疫荧光法检测NF-κB和amp活化蛋白激酶（AMPK）（能量代谢的主要调节因子）的激活情况。此外，我们在两种膝关节OA小鼠模型（n = 10）中评估了其疗效：内侧半月板不稳定和内侧副韧带横断（DMM+MCLT），以及单碘乙酸酯（MIA）诱导的OA疼痛。结果甲米明抑制il -1β诱导的oa相关基因的表达，包括促炎基因（IL6、IL1B、TNF）、分解代谢基因（MMP13、ADAMTS5）和疼痛相关基因（CCL2、NGF），并减少IL6的分泌。Western blot分析显示，IκBα和p65活化下调，AMPK上调。免疫细胞化学证实p65核易位减少（-4245 AU； 95% CI - 6765至- 1725）。在DMM+MCLT和MIA模型中，关节内给药伊米霉素降低了骨性关节炎在软骨、滑膜和半月板的组织学严重程度（OARSI评分为- 3.0 [95% CI: - 5.0至- 1.0]），减少了关节软骨中表达p- κ b α的细胞数量，减轻了骨性关节炎疼痛。结论simeglimin增强了关节组织细胞的保护功能，减轻了临床前小鼠模型的实验性OA，支持其作为治疗膝关节OA的候选药物的潜力。

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引用次数: 0

Osteoarthritis year in review 2025: Rehabilitation and outcomes including sex and gender reporting 骨关节炎2025年回顾：康复和结果包括性别和性别报告

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.10.008

Andrea M. Bruder , Matthew G. King , Chantal M. Hulshof , Harvi F. Hart , Brooke E. Patterson , Britt Elin Øiestad , Bjørnar Berg , Joanne L. Kemp , Adam G. Culvenor

This year in review (1) narratively synthesises the effect of, or patient experience with, non-pharmacological or non-surgical rehabilitation treatments for osteoarthritis at any joint; and (2) describes how sex and/or gender are defined, reported, and analysed. We searched three databases (Medline, Embase, CINAHL) for studies that met predefined criteria and selected those of perceived moderate-to-high quality and importance published between 12th March 2024 and 1st March 2025. Studies were grouped according to predominant treatment topic areas (e.g. core [exercise, diet]; adjunct [electrotherapy, manual therapy]; multimodal [different rehabilitation treatments]). Two authors independently screened records. One author extracted data, and another checked 10% of the accuracy. Full-text screening identified 158 eligible studies, reduced to 39 for synthesis. We identified eight themes: i) Exercise is effective for knee osteoarthritis and comorbidities, but has varied effects for hip osteoarthritis; ii) Diet plus exercise is effective for weight loss, but may not reduce pain; iii) Digital rehabilitation is a viable alternative to in-person care; iv) No added benefit of mind/behavioural treatments; v) Effects of electrotherapy modalities on pain were inconsistent and region-specific; vi) Orthoses may relieve pain, but should be individualised to patient preferences; vii) Acupuncture and blood flow restriction treatment show effectiveness in single clinical trials; viii) Treatment packages for osteoarthritis have varied benefits. Sex and gender were reported in 23 and 11 studies, respectively. For gender, most studies used female/male/woman/man interchangeably. No study defined sex or gender, 5% reported results disaggregated by sex or gender, no study justified why results were not, and 5% summarised key sex or gender findings.

今年的综述(1)叙述性地综合了任何关节骨关节炎的非药物或非手术康复治疗的效果或患者经验；(2)描述如何定义、报告和分析性和/或性别。我们检索了三个数据库（Medline, Embase， CINAHL）以寻找符合预定义标准的研究，并选择了2024年3月12日至2025年3月1日之间发表的被认为是中高质量和重要性的研究。研究根据主要的治疗主题领域进行分组（例如核心[运动，饮食]；辅助[电疗，手工治疗]；多模式[不同的康复治疗]）。两位作者独立筛选了记录。一位作者提取数据，另一位检查10%的准确性。全文筛选确定了158项符合条件的研究，合成研究减少到39项。我们确定了八个主题：1)运动对膝关节骨性关节炎和合并症有效，但对髋关节骨性关节炎有不同的影响；ii)饮食加运动对减肥有效，但可能不能减轻疼痛；iii)数字康复是面对面护理的可行替代方案；iv)心理/行为治疗没有额外的好处；v)电疗方式对疼痛的影响不一致且具有区域特异性；矫形器可以缓解疼痛，但应根据患者的喜好进行个体化治疗；单次临床试验表明针灸和限血治疗有效；骨关节炎的治疗方案有不同的益处。性别和社会性别分别在23项和11项研究中被报道。对于性别，大多数研究交替使用女性/男性/女性/男性。没有研究定义性别或性别，5%的研究报告了按性别或性别分类的结果，没有研究证明为什么结果不是这样，5%的研究总结了关键的性别或性别发现。

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引用次数: 0

Osteocyte-Intrinsic MMP13 Exacerbates Injury-Induced Temporomandibular Joint Osteoarthritis 骨细胞-内源性MMP13加剧损伤性颞下颌关节骨关节炎

IF 7 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-12-27 DOI: 10.1016/j.joca.2025.12.019

Cristal S. Yee, Marianne Demirdji, Karsyn N. Bailey, Alena Larios, Christoforos Meliadis, Clarissa Aguirre Luna, Harrison B. Taylor, Peggi M Angel, Sunil Kapila, Tamara Alliston

引用次数: 0

Why is there no treatment for osteoarthritis - Opportunity for AI based big data analytics to advance the field 为什么没有治疗骨关节炎的方法——基于人工智能的大数据分析推动该领域发展的机会

IF 7 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-12-26 DOI: 10.1016/j.joca.2025.12.021

F Saxer, G Jansen, S M A Bierma-Zeinstra, B Holzhauer, D Demanse, J Melnick, D Vukadinovic Greetham, T Rall, P Mesenbrink, M Schieker

引用次数: 0

Using both disease and illness as outcomes is critical in OA prevention research 在OA预防研究中，将疾病和疾病作为结果是至关重要的

IF 7 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-12-26 DOI: 10.1016/j.joca.2025.12.010

Ewa M Roos

引用次数: 0

Engineered Cationic Interleukin-1 Receptor Antagonist Outperforms Anakinra at Joint Retention and Preventing IL-1-induced Cartilage Inflammation 工程阳离子白介素-1受体拮抗剂在关节潴留和预防白介素-1诱导的软骨炎症方面优于阿那白素

IF 7 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-12-24 DOI: 10.1016/j.joca.2025.12.018

Timothy L. Boyer, Bill Hakim, Luke Childress, Helna M. Baby, Ryan M. Porter, Ambika G. Bajpayee

引用次数: 0

Why most responder analyses are misleading 为什么大多数回应分析都具有误导性

IF 7 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-12-21 DOI: 10.1016/j.joca.2025.12.020

Aleksandra Turkiewicz, Marius Henriksen, Jos Runhaar, Martin Englund

引用次数: 0

Reframing Early-stage Symptomatic Knee Osteoarthritis (EsSKOA): A Strategic Lens for Trial Design 重构早期症状性膝骨关节炎（EsSKOA）：试验设计的一个策略镜头

IF 7 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-12-20 DOI: 10.1016/j.joca.2025.12.016

Armaghan Mahmoudian, Lauren K King, Jean W Liew, Qiuke Wang, Francis Berenbaum, Siddharth Das, Changhai Ding, Carolyn A Emery, Stephanie R Filbay, Marc C Hochberg, Muneaki Ishijima, Margreet Kloppenburg, Nancy E Lane, Elena Losina, Ali Mobasheri, C Thomas Appleton, Martin Englund, L Stefan Lohmander, Jos Runhaar, Aleksandra Turkiewicz, Gillian A Hawker, Tuhina Neogi, Ida K Haugen

引用次数: 0

Metformin and incident osteoarthritis: Causal insights from a co-twin control study 二甲双胍和骨关节炎：来自双胎对照研究的因果见解

IF 7 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-12-19 DOI: 10.1016/j.joca.2025.12.014

Karin Magnusson, Aleksandra Turkiewicz, Andrea Dell’Isola, Ali Kiadaliri, Martin Englund

引用次数: 0

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