Osteoarthritis and Cartilage最新文献_第4页

Dampened inflammation and reduced risk of osteoarthritis among non-industrialized societies 在非工业化社会中抑制炎症和降低骨关节炎的风险。

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.09.014

Ian J. Wallace , David T. Felson , Virginia B. Kraus , Tuhina Neogi , Ida K. Haugen , Janet L. Huebner , Cecilia M.T. Sena , Tracy L. Kivell , Nicholas B. Holowka , Steven Worthington , Yvonne A.L. Lim , Vivek V. Venkataraman , Thomas S. Kraft , Amanda J. Lea

Objectives

Anthropological research suggests that people in non-industrialized societies (hunter-gatherers, subsistence farmers, pastoralists) are at lower risk of osteoarthritis than people in industrialized societies. Here, we propose that this may be due to people in non-industrialized societies having dampened inflammatory activity, a key factor in osteoarthritis pathogenesis.

Design

This narrative review focuses on evidence that four environmental variables common among non-industrialized societies contribute to dampening inflammatory activity and thus potentially lowering OA risk: low levels of adiposity, high physical activity levels, diets consisting of minimally processed foods, and infections from helminths.

Results

Although people in non-industrialized societies experience intermittent, pathogen-induced spikes in inflammation, they do not typically experience the chronic, low-grade pattern of inflammation implicated in osteoarthritis pathogenesis. Excess adipose tissue is well documented to be a potent source of pro-inflammatory mediators involved in osteoarthritis pathogenesis; thus, the rarity of obesity among non-industrialized societies is likely a major reason for any reduced osteoarthritis risk. Physical activity and diet among non-industrialized societies have the potential to curb inflammation and osteoarthritis through several mechanistic pathways, yet the relative importance of each pathway has yet to be fully resolved. A role for helminths in dampening inflammation and lowering OA risk is theoretically plausible but speculative based on current evidence.

Conclusions

More research among non-industrialized societies will be required to rigorously investigate the links proposed here between industrialization, inflammation, and risk of osteoarthritis. Opportunities to do so are disappearing, as lifestyles among such societies are rapidly changing.

目的人类学研究表明，非工业化社会（狩猎采集者、自给自足的农民、牧民）的人患骨关节炎的风险低于工业化社会的人。在这里，我们提出这可能是由于非工业化社会的人们抑制了炎症活动，这是骨关节炎发病的一个关键因素。本叙述性综述的重点是在非工业化社会中常见的四个环境变量有助于抑制炎症活动，从而潜在地降低OA风险的证据：低脂肪水平、高体力活动水平、由最低加工食品组成的饮食和蠕虫感染。结果：尽管非工业化社会的人们会经历间歇性的、病原体引起的炎症峰值，但他们通常不会经历与骨关节炎发病机制有关的慢性、低度炎症模式。多余的脂肪组织被充分证明是参与骨关节炎发病的促炎介质的有力来源；因此，在非工业化社会中，肥胖的罕见可能是降低骨关节炎风险的主要原因。在非工业化社会中，体育活动和饮食有可能通过几种机制途径抑制炎症和骨关节炎，但每种途径的相对重要性尚未得到充分解决。蠕虫在抑制炎症和降低OA风险方面的作用在理论上是合理的，但基于目前的证据是推测性的。结论需要在非工业化社会中进行更多的研究，以严格调查工业化、炎症和骨关节炎风险之间的联系。这样做的机会正在消失，因为这些社会的生活方式正在迅速改变。

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引用次数: 0

Osteoarthritis year in review 2025: Imaging 骨关节炎年回顾2025：影像学。

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.11.004

Matthew S. Harkey , Anthony A. Gatti , Mylène P. Jansen , McKenzie S. White , Jessica Tolzman , Arjun Parmar , Ian Frederick , Thomas M. Link , Harvi F. Hart

Objective

To conduct a narrative review of selected imaging studies published in the past year, with a focus on how emerging methods and multi-tissue assessments are contributing to disease characterization, early detection, and intervention strategies.

Design

We conducted a comprehensive search strategy of PubMed, Embase, and CINAHL for original English-language human studies on imaging in osteoarthritis, published between March 2024 and March 2025. From the 262 full-text studies that met inclusion criteria, we identified a set of representative studies through independent review and group discussion. These studies are organized into five themes that emerged from this study: effusion-synovitis, infrapatellar fat pad, muscle, subchondral bone, and subcutaneous fat. Within each theme, one highlighted study and several additional studies were synthesized, followed by a summary of cross-cutting insights and future directions.

Results

A total of 26 studies were included. Collectively, the studies reinforce the importance of viewing osteoarthritis as a condition involving multiple joint structures, with inflammation as a recurring feature across tissues. Muscle quality and local adiposity emerged as consistent imaging biomarkers, while accessible tools such as ultrasound and AI-enhanced radiography demonstrated potential for scalable clinical application. Links between imaging findings and biomechanics, particularly gait and loading patterns, also featured prominently. Cross-cutting themes emphasized the value of considering multiple tissues, expanding the reach of imaging to clinical and community settings, and integrating imaging with functional measures.

Conclusions

Imaging research in the osteoarthritis continues to broaden in scope and application. The studies highlighted in this review illustrate how advances in methods and metrics are improving opportunities for earlier detection, more precise assessment of symptoms, and the development of targeted, structure-informed interventions.

目的对过去一年中发表的精选影像学研究进行综述，重点关注新兴方法和多组织评估如何有助于疾病表征、早期发现和干预策略。我们对PubMed， Embase和CINAHL进行了全面的搜索策略，以获取在2024年3月至2025年3月之间发表的关于骨关节炎成像的原始英语人类研究。从符合纳入标准的262项全文研究中，我们通过独立审查和小组讨论确定了一组具有代表性的研究。这些研究被分为五个主题：积液-滑膜炎、髌下脂肪垫、肌肉、软骨下骨和皮下脂肪。在每个主题中，综合了一个重点研究和几个附加研究，然后总结了交叉见解和未来方向。结果共纳入26项研究。总的来说，这些研究强调了将骨关节炎视为一种涉及多个关节结构的疾病的重要性，炎症是组织中反复出现的特征。肌肉质量和局部肥胖成为一致的成像生物标志物，而超声和人工智能增强放射照相等可获得的工具显示出可扩展临床应用的潜力。成像结果与生物力学之间的联系，特别是步态和负荷模式，也很突出。交叉主题强调了考虑多种组织的价值，将成像范围扩大到临床和社区环境，并将成像与功能测量相结合。结论骨关节炎影像学研究的范围和应用不断拓宽。本综述中强调的研究说明了方法和指标的进步如何改善了早期发现的机会，更精确地评估症状，并开发了有针对性的、结构知情的干预措施。

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引用次数: 0

Response to letter to the editor regarding ‘The relation of walking forces to structural damage in the knee: The Multicenter Osteoarthritis Study’ 关于“步行力与膝关节结构损伤的关系：多中心骨关节炎研究”致编辑的回复

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.11.006

Lauren K. Sara, David T. Felson, Michael P. LaValley, Joshua J. Stefanik, Cara L. Lewis

引用次数: 0

Filler advert: knovel_210x280.pdf 填充广告：knovel_210x280.pdf

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/S1063-4584(25)01284-1

引用次数: 0

A decade of exposure: Long-term air pollution and its impact on osteoarthritis: A nationwide cohort study in Taiwan 十年暴露：长期空气污染及其对骨关节炎的影响：台湾一项全国性队列研究。

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.04.011

Yi-Chuan Chan , Yen-Wei Huang , Shu-Han Chuang , Yi-Jie Kuo , Yu-Pin Chen

Objective

To investigate the association between long-term exposure to ambient air pollution and the risk of developing osteoarthritis (OA) in a large nationwide cohort in Taiwan.

Design

We conducted a retrospective cohort study using data from Taiwan's National Health Insurance Research Database linked with air pollution monitoring records from 76 environmental stations between 1993 and 2013. A total of 526,630 adults with complete 10-year cumulative exposure data were followed from the end of the exposure window until OA diagnosis, death, or study end. Cox proportional hazards models were applied to estimate hazard ratios (HRs) per standard deviation (SD) increase in pollutant exposure, adjusting for demographic, socioeconomic, and clinical confounders. Pollutants that satisfied the proportional hazards assumption (carbon monoxide [CO], particles less than 10 μm in diameter [PM₁₀], and nitrogen dioxide [NO₂]) were included in the final analysis to ensure model validity.

Results

During follow-up, 58,369 incident OA cases were identified (11.08% incidence). A 1 SD increase in CO, PM₁₀, and NO₂ exposure was associated with HRs of 1.83 (95% confidence interval: 1.81–1.84), 1.58 (1.56–1.60), and 1.62 (1.61–1.64), respectively (all p < 0.001). These associations were robust across sex subgroups and exhibited consistent dose-response relationships.

Conclusions

We observed a significant association between prolonged exposure to CO, PM₁₀, and NO₂ and increased OA risk. These findings support air pollution as a modifiable risk factor for OA and highlight the importance of environmental health interventions in disease prevention strategies.

目的探讨台湾地区长期暴露于环境空气污染与患骨关节炎（OA）风险的关系。从暴露窗口结束到OA诊断、死亡或研究结束，共有526,630名具有完整10年累积暴露数据的成年人接受了随访。Cox比例风险模型用于估计污染物暴露每标准差（SD）增加的风险比（hr），并对人口统计学、社会经济和临床混杂因素进行调整。满足比例危害假设的污染物（CO、PM₁₀和NO₂）被纳入最终分析，以确保模型的有效性。结果随访共发现OA 58,369例，发生率11.08%。CO， PM₁0和NO₂暴露增加1个标准差与hr分别为1.83 (95% CI: 1.81-1.84), 1.58（1.56-1.60）和1.62（1.61-1.64）相关（均p < 0.001）。这些关联在性别亚组中都很明显，并表现出一致的剂量-反应关系。结论：我们观察到长期暴露于CO、PM 1 0和NO 2与OA风险增加之间存在显著关联。这些发现支持空气污染是OA的一个可改变的风险因素，并强调了环境卫生干预在疾病预防战略中的重要性。

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引用次数: 0

Same pain, different brainstem: Sex-dependent astrocytic activation in the rostral ventromedial medulla during experimental osteoarthritis 相同的疼痛，不同的脑干：实验性骨关节炎期间吻侧腹内侧髓质中性别依赖的星形细胞激活。

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.10.006

Diana Fonseca-Rodrigues , Inês Laranjeira , Luiz Falconi-Sobrinho , Juliana Fiúza-Fernandes , Beatriz Soares , Luísa Pinto , Filipa Pinto-Ribeiro

Objective

Osteoarthritis (OA) is the leading cause of chronic pain worldwide. Functional studies showed a critical role of descending facilitation, involving the rostral ventromedial medulla (RVM), in the establishment of pain chronicity. Glial cells such as microglia and astrocytes can contribute to chronic pain through the facilitation of neuronal excitability. This work aimed to characterize the morpho-structural changes in the RVM induced by experimental OA (eOA) pain and to identify potential sexual dimorphisms.

Methods

The kaolin/carrageenan model of eOA was induced in 23 male and 22 female Wistar Han rats. Four weeks later, brain samples were collected and divided into two analyses: stereological evaluation of changes in neuronal/glial cell density within the RVM, and immunohistochemical analysis of glial activation, astrocyte proliferation and structural changes.

Results

While no major differences were found in the RVM volume or area, osteoarthritic females exhibited a higher glia-to-neuron ratio (95%CI: 0.13–0.76; p=0.006), driven by increased glial cell density. A significant increase in GFAP-positive cells was observed in females (95%CI: 1.95–25.8; p=0.025), without a corresponding increase in Iba1 immunoreactivity, an effect not seen in males. Increased mitotic activity and structural complexity of astrocytes in osteoarthritic females were further confirmed by immunofluorescence and Sholl analysis, respectively.

Conclusions

Our findings highlight the intricate relationship between eOA-related pain and the RVM cellular dynamics, revealing sex-specific astrocyte activation following eOA and its potential role in the mediation pain processing and chronification. These results suggest targeting astrocyte-mediated mechanisms as potential sex-specific therapeutic strategy for OA pain management.

目的骨关节炎（OA）是世界范围内慢性疼痛的主要原因。功能研究表明，下行促进作用，包括吻侧腹内侧延髓（RVM），在疼痛慢性的建立中起关键作用。神经胶质细胞如小胶质细胞和星形胶质细胞可以通过促进神经元兴奋性来促进慢性疼痛。这项工作旨在表征实验性OA （eOA）疼痛引起的RVM形态结构变化，并确定潜在的性别二态性。方法采用高岭土/卡拉胶法制备23只雄性Wistar Han大鼠和22只雌性Wistar Han大鼠eOA模型。4周后，收集脑样本，分为两个分析：RVM内神经元/胶质细胞密度变化的体视学评估，以及胶质细胞激活、星形胶质细胞增殖和结构变化的免疫组织化学分析。结果虽然RVM的体积和面积没有明显差异，但骨性关节炎女性由于胶质细胞密度增加，胶质细胞与神经元的比例更高（95%CI: 0.13-0.76; p=0.006）。在女性中观察到gfap阳性细胞显著增加（95%CI: 1.95-25.8; p=0.025），而Iba1免疫反应性未相应增加，这在男性中未见。免疫荧光和Sholl分析进一步证实了骨关节炎女性星形细胞有丝分裂活性和结构复杂性的增加。结论我们的研究结果强调了eOA相关疼痛与RVM细胞动力学之间的复杂关系，揭示了eOA后性别特异性星形胶质细胞激活及其在介导疼痛加工和慢性化中的潜在作用。这些结果表明，针对星形胶质细胞介导的机制是OA疼痛管理的潜在性别特异性治疗策略。

{"title":"Same pain, different brainstem: Sex-dependent astrocytic activation in the rostral ventromedial medulla during experimental osteoarthritis","authors":"Diana Fonseca-Rodrigues , Inês Laranjeira , Luiz Falconi-Sobrinho , Juliana Fiúza-Fernandes , Beatriz Soares , Luísa Pinto , Filipa Pinto-Ribeiro","doi":"10.1016/j.joca.2025.10.006","DOIUrl":"10.1016/j.joca.2025.10.006","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis (OA) is the leading cause of chronic pain worldwide. Functional studies showed a critical role of descending facilitation, involving the rostral ventromedial medulla (RVM), in the establishment of pain chronicity. Glial cells such as microglia and astrocytes can contribute to chronic pain through the facilitation of neuronal excitability. This work aimed to characterize the morpho-structural changes in the RVM induced by experimental OA (eOA) pain and to identify potential sexual dimorphisms.</div></div><div><h3>Methods</h3><div>The kaolin/carrageenan model of eOA was induced in 23 male and 22 female Wistar Han rats. Four weeks later, brain samples were collected and divided into two analyses: stereological evaluation of changes in neuronal/glial cell density within the RVM, and immunohistochemical analysis of glial activation, astrocyte proliferation and structural changes.</div></div><div><h3>Results</h3><div>While no major differences were found in the RVM volume or area, osteoarthritic females exhibited a higher glia-to-neuron ratio (95%CI: 0.13–0.76; p=0.006), driven by increased glial cell density. A significant increase in GFAP-positive cells was observed in females (95%CI: 1.95–25.8; p=0.025), without a corresponding increase in Iba1 immunoreactivity, an effect not seen in males. Increased mitotic activity and structural complexity of astrocytes in osteoarthritic females were further confirmed by immunofluorescence and Sholl analysis, respectively.</div></div><div><h3>Conclusions</h3><div>Our findings highlight the intricate relationship between eOA-related pain and the RVM cellular dynamics, revealing sex-specific astrocyte activation following eOA and its potential role in the mediation pain processing and chronification. These results suggest targeting astrocyte-mediated mechanisms as potential sex-specific therapeutic strategy for OA pain management.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 1","pages":"Pages 70-81"},"PeriodicalIF":9.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Partitioning knee osteoarthritis genetic variants based on BMI association to improve polygenic risk prediction 基于BMI关联划分膝骨关节炎遗传变异以改善多基因风险预测。

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.09.018

Bahar Sedaghati–Khayat , Katerina Trajanoska , Cindy G. Boer , Fernando Rivadeneira , André G. Uitterlinden , Joyce B.J. van Meurs , Jeroen G.J. van Rooij

Introduction

Polygenic risk scores (PRSs) show promise for improving knee osteoarthritis (KOA) risk prediction. However, many KOA-associated variants are also linked to body mass index (BMI)—a major KOA risk factor—complicating the combined use of PRS and BMI in predictive models. This study aimed to disentangle BMI-mediated from BMI-independent genetic contributions to KOA by partitioning the KOA-PRS.

Method

Using data from 345,080 white European participants in the UK Biobank, we refined a KOA-PRS based on 146 genome-wide significant variants identified by the GO consortium. KOA variants were partitioned into BMI-associated (KOA-BMI PRS), and BMI-independent (KOA-nonBMI PRS) groups based on linkage disequilibrium with BMI-associated variants from the GIANT consortium. We assessed associations of each PRS with prevalent and incident KOA (with and without BMI adjustment), with BMI in cases and controls, and with KOA across BMI strata.

Results

Of the 146 KOA-associated variants, 73 were classified as BMI-associated. The KOA-BMI PRS was associated with incident KOA (OR per SD:1.23;95%CI:1.20–1.26), attenuated after BMI adjustment (1.18;1.15–1.21). In contrast, the KOA-nonBMI PRS remained robust to BMI adjustment (1.24 before vs.1.23 after-adjustment). KOA-nonBMI PRS was negatively associated with BMI in KOA cases (β=–0.09;95%CI:–0.17to–0.01), but not in controls. Stratified analyses showed its effect on KOA diminished in higher BMI strata, while KOA-BMI PRS effects remained stable.

Conclusion

Half of KOA-associated variants overlap with BMI loci. Partitioning the KOA-PRS improves interpretation by distinguishing BMI-driven from independent genetic effects—enhancing prediction and informing tailored prevention. Validation in diverse populations is warranted.

多基因风险评分（PRSs）有望改善膝骨关节炎（KOA）的风险预测。然而，许多与KOA相关的变异也与身体质量指数（BMI）有关，这是一个主要的KOA风险因素，使PRS和BMI在预测模型中的联合使用复杂化。本研究旨在通过划分KOA- prs来解开bmi介导的与bmi独立的遗传对KOA的贡献。方法使用来自英国生物银行345,080名欧洲白人参与者的数据，我们基于GO联盟鉴定的146个全基因组显著变异完善了KOA-PRS。根据与GIANT联盟中bmi相关变异的连锁不平衡，将KOA变异分为bmi相关（KOA- bmi PRS）和bmi独立（KOA-非bmi PRS）两组。我们评估了每一种PRS与流行的和偶发的KOA（有和没有BMI调整）、病例和对照组的BMI以及不同BMI层的KOA的关联。结果146例koa相关变异中，73例归为bmi相关。KOA-BMI PRS与KOA事件相关（OR / SD:1.23;95%CI:1.20 ~ 1.26）， BMI调整后减弱（1.18;1.15 ~ 1.21）。相比之下，koa -非BMI PRS对BMI调整保持稳健（调整前为1.24，调整后为1.23）。在KOA病例中，KOA-非BMI PRS与BMI呈负相关（β=-0.09;95%CI:-0.17 -0.01），但在对照组中没有。分层分析表明，高BMI地层对KOA的影响减弱，而KOA-BMI PRS效应保持稳定。结论半数koa相关变异与BMI位点重叠。通过区分bmi驱动和独立的遗传效应，划分KOA-PRS改善了解释，增强了预测，并为量身定制的预防提供了信息。有必要在不同人群中进行验证。

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引用次数: 0

Response to the Letter to the Editor: Effects of pre- and postsurgery physical activity interventions on physical activity and sedentary behavior levels following knee and hip arthroplasty: A systematic review and meta-analysis of randomized controlled trials 给编辑的回复：术前和术后体育活动干预对膝关节和髋关节置换术后体育活动和久坐行为水平的影响：随机对照试验的系统回顾和荟萃分析

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.10.013

Noah d’Unienville, Bethany Gower, Ben Singh, Kimberley Szeto, Heather Badger, Matilda Krywanio, Carol Maher , Dominic Thewlis

引用次数: 0

Imeglimin, a novel antidiabetic agent related to metformin, attenuates knee osteoarthritis development and progression through AMPK activation and NF-κB signaling inhibition 依米明是一种由二甲双胍合成的新型降糖药物，通过激活AMPK和抑制NF-κB信号传导来减轻膝关节骨性关节炎的发生和进展

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.11.007

Yuki Hyodo , Yukio Akasaki , Ichiro Kurakazu , Masanari Kuwahara , Taisuke Uchida , Ryota Hirose , Mamiko Sakai , Takumi Kita , Koki Kato , Yasuharu Nakashima

Objective

Metformin, a first-line treatment for type 2 diabetes, attenuates hallmarks of aging and protects against age-related diseases, including osteoarthritis (OA). Here, we assessed the effects of imeglimin, a novel antidiabetic agent related to metformin, on the development and progression of knee OA.

Design

Primary human OA chondrocytes, synovial cells, and meniscal cells were stimulated with IL-1β and treated with imeglimin (n = 8). OA-related gene and protein expressions were quantified using RT-qPCR and ELISA. Activation of NF-κB and AMP-activated protein kinase (AMPK), a master regulator of energy metabolism, was assessed using western blotting and immunofluorescence. Additionally, we evaluated its efficacy in two knee OA mouse models (n = 10): destabilization of the medial meniscus and medial collateral ligament transection (DMM+MCLT), and monoiodoacetate (MIA)-induced OA pain.

Results

Imeglimin suppressed IL-1β-induced expressions of OA-related genes, including pro-inflammatory (IL6, IL1B, TNF), catabolic (MMP13, ADAMTS5), and pain-related (CCL2, NGF) genes, and reduced IL6 secretion. Western blot analysis revealed downregulation of IκBα and p65 activation and AMPK upregulation. Immunocytochemistry confirmed decreased p65 nuclear translocation (-4245 AU; 95% CI −6765 to −1725). Intra-articular administration of imeglimin reduced histological severity of OA in cartilage, synovium, and meniscus in DMM+MCLT mice (OARSI grade, −3.0 [95% CI: −5.0 to −1.0]), decreased the number of cells expressing p-IκBα in the articular cartilage, and attenuated OA pain in both DMM+MCLT and MIA models.

Conclusions

Imeglimin enhances protective functions in joint tissue cells and alleviates experimental OA in preclinical mouse models, supporting its potential as a therapeutic candidate for knee OA.

目的：甲双胍是2型糖尿病的一线治疗药物，它可以减轻衰老的标志，并预防与年龄相关的疾病，包括骨关节炎（OA）。在这里，我们评估了一种与二甲双胍相关的新型降糖药伊米明对膝关节OA发生和进展的影响。设计：用IL-1β刺激原代人OA软骨细胞、滑膜细胞和半月板细胞，并用伊米霉素处理（n = 8）。采用RT-qPCR和ELISA检测oa相关基因及蛋白的表达。采用western blotting和免疫荧光法检测NF-κB和amp活化蛋白激酶（AMPK）（能量代谢的主要调节因子）的激活情况。此外，我们在两种膝关节OA小鼠模型（n = 10）中评估了其疗效：内侧半月板不稳定和内侧副韧带横断（DMM+MCLT），以及单碘乙酸酯（MIA）诱导的OA疼痛。结果甲米明抑制il -1β诱导的oa相关基因的表达，包括促炎基因（IL6、IL1B、TNF）、分解代谢基因（MMP13、ADAMTS5）和疼痛相关基因（CCL2、NGF），并减少IL6的分泌。Western blot分析显示，IκBα和p65活化下调，AMPK上调。免疫细胞化学证实p65核易位减少（-4245 AU； 95% CI - 6765至- 1725）。在DMM+MCLT和MIA模型中，关节内给药伊米霉素降低了骨性关节炎在软骨、滑膜和半月板的组织学严重程度（OARSI评分为- 3.0 [95% CI: - 5.0至- 1.0]），减少了关节软骨中表达p- κ b α的细胞数量，减轻了骨性关节炎疼痛。结论simeglimin增强了关节组织细胞的保护功能，减轻了临床前小鼠模型的实验性OA，支持其作为治疗膝关节OA的候选药物的潜力。

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引用次数: 0

Osteoarthritis year in review 2025: Rehabilitation and outcomes including sex and gender reporting 骨关节炎2025年回顾：康复和结果包括性别和性别报告

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.10.008

Andrea M. Bruder , Matthew G. King , Chantal M. Hulshof , Harvi F. Hart , Brooke E. Patterson , Britt Elin Øiestad , Bjørnar Berg , Joanne L. Kemp , Adam G. Culvenor

This year in review (1) narratively synthesises the effect of, or patient experience with, non-pharmacological or non-surgical rehabilitation treatments for osteoarthritis at any joint; and (2) describes how sex and/or gender are defined, reported, and analysed. We searched three databases (Medline, Embase, CINAHL) for studies that met predefined criteria and selected those of perceived moderate-to-high quality and importance published between 12th March 2024 and 1st March 2025. Studies were grouped according to predominant treatment topic areas (e.g. core [exercise, diet]; adjunct [electrotherapy, manual therapy]; multimodal [different rehabilitation treatments]). Two authors independently screened records. One author extracted data, and another checked 10% of the accuracy. Full-text screening identified 158 eligible studies, reduced to 39 for synthesis. We identified eight themes: i) Exercise is effective for knee osteoarthritis and comorbidities, but has varied effects for hip osteoarthritis; ii) Diet plus exercise is effective for weight loss, but may not reduce pain; iii) Digital rehabilitation is a viable alternative to in-person care; iv) No added benefit of mind/behavioural treatments; v) Effects of electrotherapy modalities on pain were inconsistent and region-specific; vi) Orthoses may relieve pain, but should be individualised to patient preferences; vii) Acupuncture and blood flow restriction treatment show effectiveness in single clinical trials; viii) Treatment packages for osteoarthritis have varied benefits. Sex and gender were reported in 23 and 11 studies, respectively. For gender, most studies used female/male/woman/man interchangeably. No study defined sex or gender, 5% reported results disaggregated by sex or gender, no study justified why results were not, and 5% summarised key sex or gender findings.

今年的综述(1)叙述性地综合了任何关节骨关节炎的非药物或非手术康复治疗的效果或患者经验；(2)描述如何定义、报告和分析性和/或性别。我们检索了三个数据库（Medline, Embase， CINAHL）以寻找符合预定义标准的研究，并选择了2024年3月12日至2025年3月1日之间发表的被认为是中高质量和重要性的研究。研究根据主要的治疗主题领域进行分组（例如核心[运动，饮食]；辅助[电疗，手工治疗]；多模式[不同的康复治疗]）。两位作者独立筛选了记录。一位作者提取数据，另一位检查10%的准确性。全文筛选确定了158项符合条件的研究，合成研究减少到39项。我们确定了八个主题：1)运动对膝关节骨性关节炎和合并症有效，但对髋关节骨性关节炎有不同的影响；ii)饮食加运动对减肥有效，但可能不能减轻疼痛；iii)数字康复是面对面护理的可行替代方案；iv)心理/行为治疗没有额外的好处；v)电疗方式对疼痛的影响不一致且具有区域特异性；矫形器可以缓解疼痛，但应根据患者的喜好进行个体化治疗；单次临床试验表明针灸和限血治疗有效；骨关节炎的治疗方案有不同的益处。性别和社会性别分别在23项和11项研究中被报道。对于性别，大多数研究交替使用女性/男性/女性/男性。没有研究定义性别或性别，5%的研究报告了按性别或性别分类的结果，没有研究证明为什么结果不是这样，5%的研究总结了关键的性别或性别发现。

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引用次数: 0