Osteoarthritis and Cartilage最新文献

{"title":"Effect of arthroscopic partial meniscectomy on structural degeneration of the knee – A 5-year MRI-based follow-up of the placebo-surgery controlled FIDELITY (Finnish Degenerative Meniscus Lesion Study) trial","authors":"Niko Sillanpää, Marika Iivanainen, Aleksandra Turkiewicz, Raine Sihvonen, Mika Paavola, Simo Taimela, Teppo L.N. Järvinen, Martin Englund","doi":"10.1016/j.joca.2024.09.003","DOIUrl":"https://doi.org/10.1016/j.joca.2024.09.003","url":null,"abstract":"To assess the 5-year effects of arthroscopic partial meniscectomy (APM) vs. placebo surgery on the development of the structural changes of the knee by magnetic resonance imaging (MRI).","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"13 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142246763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antihistamine use and osteoarthritis or joint pain","authors":"Aleksandra Turkiewicz, Clara Hellberg, Andrea Dell’Isola, Martin Englund","doi":"10.1016/j.joca.2024.09.004","DOIUrl":"https://doi.org/10.1016/j.joca.2024.09.004","url":null,"abstract":"Antihistamines have been reported to be linked with less pain in osteoarthritis. We aimed to estimate associations between antihistamine use and three outcomes: prevalent osteoarthritis, current joint pain, and developing osteoarthritis.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"12 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142246814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationships between patellofemoral bone remodeling, cartilage composition, and vertical loading rate: PET/MRI in isolated patellofemoral osteoarthritis","authors":"Rupsa Bhattacharjee ,&nbsp;Eric Hammond ,&nbsp;Ngarmsrikam Chotigar ,&nbsp;Zehra Akkaya ,&nbsp;Fei Jiang ,&nbsp;Emma Bahroos ,&nbsp;Misung Han ,&nbsp;Spencer Behr ,&nbsp;Matthew D. Bucknor ,&nbsp;Richard B. Souza ,&nbsp;Valentina Pedoia ,&nbsp;Sharmila Majumdar","doi":"10.1016/j.joca.2024.09.001","DOIUrl":"10.1016/j.joca.2024.09.001","url":null,"abstract":"<div><h3>Objective</h3><div>Loading is invariably an important factor of consideration for understanding the causality flow and parallel existence of articular cartilage and subchondral bone changes. The goal of this study was to investigate the patterns of subregional ¹⁸NaF-SUV vs. T_1<em>p</em>-T₂ associations and vertical ground reaction force loading rates; in isolated patellofemoral-joint-osteoarthritis (PFJ-OA) patients.</div></div><div><h3>Method</h3><div>Thirty-five isolated PFJ-OA patients, with no tibiofemoral involvement, underwent simultaneous scans in a 3.0T whole-body hybrid positron emission tomography–magnetic resonance imaging scanner. MRI Whole-Organ Magnetic Resonance Imaging Scoring assessments were performed to identify/confirm isolated PFJ-OA knees from bilateral scans. T_1<em>p</em>-T₂ relaxation and SUV values were automatically computed for both trochlear and patellar cartilage and subchondral bone subregions (deep, superficial, lateral, and medial). Maximum vertical impact loading rates (Loading-Rate_Norm) were calculated from walking trials. Relationships were explored between SUV uptake, T_1<em>p</em>-T₂ values, and Loading-Rate_Norm via linear mixed-effects modeling.</div></div><div><h3>Results</h3><div>Significant and complex association patterns were noted between medial and lateral bone ¹⁸NaF-SUV uptakes vs. medial and lateral cartilage sub-regional T_1<em>p</em> and T₂. SUV_Mean and SUV_Max were positively associated with deep cartilage subregional T_1<em>p</em> <em>and</em> T₂ values; and negatively associated with superficial cartilage subregional T_1<em>p</em><em>-</em>T₂ values in both medial and lateral regions. Both medial and lateral bone ¹⁸NaF-SUV_Mean and SUV_Max uptakes remained positively associated with the individual gait characteristics, i.e., peak vertical impact loading rates (Loading-Rate_Norm).</div></div><div><h3>Conclusion</h3><div>Evidence of simultaneous, complementary, cross-sectional associations between T_1<em>p</em><em>-</em>T₂ values and peak vertical loading rates with ¹⁸NaF-SUV, have been rare in the isolated PFJ-OA cohort. The clinical implications of such novel associations remain of utmost importance from a gait retraining perspective.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"32 12","pages":"Pages 1591-1600"},"PeriodicalIF":7.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142246856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of intra-articular interventions for knee and hip osteoarthritis based on large randomised trials: a systematic review and network meta-analysis.","authors":"Tiago V Pereira,Pakeezah Saadat,Pavlos Bobos,Samir M Iskander,Nicolas S Bodmer,Martina Rudnicki,Henry Dan Kiyomoto,Thais Montezuma,Matheus O Almeida,Rishi Bansal,Pai-Shan Cheng,Jason W Busse,Alex J Sutton,Peter Tugwell,Gillian A Hawker,Peter Jüni,Bruno R da Costa","doi":"10.1016/j.joca.2024.08.014","DOIUrl":"https://doi.org/10.1016/j.joca.2024.08.014","url":null,"abstract":"OBJECTIVETo quantify the effectiveness and safety of intra-articular interventions for knee and hip osteoarthritis through a systematic review and Bayesian random-effects network meta-analysis.DESIGNWe searched CENTRAL and regulatory agency websites (inception-2023) for large, English-language, randomised controlled trials (RCTs) (≥100 patients/group) examining any intra-articular intervention.PRIMARY OUTCOMEpain intensity.SECONDARY OUTCOMESphysical function and safety outcomes. Pain and function outcomes were analyzed at 2,6,12,24, and 52 weeks post-randomization, and presented as standardized mean differences (SMDs) (95% credible intervals, 95%CrI). The prespecified minimal clinically important between-group difference (MID) was -0.37 SMD. Safety outcomes were presented as odds ratios (OR) (95%CrI).FINDINGSAmong 57 RCTs (22,795 participants) examining 18 intra-articular interventions, usual care or placebo, treatment effects were larger in high-risk-of-bias trials (n=35) than low/unclear-risk-of-bias trials (n=22). In the main analysis (excluding high-risk-of-bias trials), triamcinolone had the highest probabilities of reaching the MID at weeks 2-6 (75.3% and 90%, respectively) with corresponding SMDs of -0.48 (95%CrI,-0.85 to -0.10) and -0.53 (95%CrI,-0.79 to -0.27) compared to placebo. Tr14/Ze14 homeopathic product showed therapeutic potential at week 6 compared to placebo (SMD:-0.42, 95%CrI,-0.71 to -0.11, 63.5% probability of reaching the MID). Hyaluronic acid had higher risk of dropouts due to adverse events (OR:2.01, 95%CrI,1.08 to 3.77) and serious adverse events (OR:1.86, 95%CrI,1.16 to 3.03) than placebo.CONCLUSIONTriamcinolone had the highest probabilities to have a treatment effect beyond the MID at weeks 2-6. Large RCTs with lower risk of bias do not support the notion that 16 other intra-articular interventions assessed improve pain or function beyond placebo effects in knee or hip OA. Lack of evidence of long-term effectiveness underscores the need for further research beyond 24-52 weeks.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"1 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142231325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence-based hierarchy of pain outcome measures for osteoarthritis clinical trials and meta-analyses","authors":"Pakeezah Saadat, Tiago V. Pereira, Rahim Lalji, Henry D. Kiyomoto, Nicolas S. Bodmer, Pavlos Bobos, Samir Iskander, Areti-Angeliki Veroniki, Gillian A. Hawker, Alex J. Sutton, Peter Jüni, Bruno R. da Costa","doi":"10.1016/j.joca.2024.08.013","DOIUrl":"https://doi.org/10.1016/j.joca.2024.08.013","url":null,"abstract":"To rank commonly used patient-reported outcome measures (PROMs) for assessing pain in osteoarthritis trials according to their assay sensitivity, defined as the ability of a PROM to distinguish an effective from a less effective intervention or placebo, proposing a hierarchy for PROM selection in trials and data-extraction in meta-analyses. Analysis of trials with placebo, sham, or non-intervention control that included ≥100 patients per arm with knee/hip osteoarthritis, reporting treatment effects on ≥2 pain PROMs. Treatment effects from all PROMs were standardized on a 0–100 scale. Negative mean differences indicated a larger effect of the experimental treatment compared to control. We ranked PROMs by assay sensitivity using a Bayesian multi-outcome synthesis random-effects model. 135 trials comprising 57,141 participants were included. The ranking of PROMs from highest to lowest assay sensitivity was as follows: pain overall, pain on stairs, pain at night, pain on walking, pain at rest, WOMAC pain, WOMAC global, Lequesne index. Pain overall, the highest-ranked PROM, had a pooled mean difference of −6.96 (95%CrI −7.94, −6.02), while WOMAC pain, the most reported PROM in our study, had a pooled mean difference of −4.90 (95%CrI −5.55, −4.26). The pooled ratio of mean differences between pain overall and WOMAC pain was 1.42 (95%CrI 1.30, 1.55), representing a 42% larger effect size with pain overall. Pain overall has better assay sensitivity than other pain PROMs. Investigators should consider the hierarchy proposed in this study to guide PROM selection in osteoarthritis clinical trials and data extraction in osteoarthritis meta-analyses.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"44 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142142422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two studies of nerve growth factor (NGF) inhibitors implemented a rigorous mitigation plan to exclude osteoarthritis patients with a risk of joint collapse, but it was still not enough!","authors":"Ali Guermazi","doi":"10.1016/j.joca.2024.08.011","DOIUrl":"10.1016/j.joca.2024.08.011","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"32 12","pages":"Pages 1518-1521"},"PeriodicalIF":7.2,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of weight loss interventions in overweight and obese adults with knee osteoarthritis: A systematic review and network meta-analysis of randomized trials.","authors":"Arashi Shahid, Aricia Jieqi Thirumaran, Robin Christensen, Venkatesha Venkatesha, Marius Henriksen, Jocelyn L Bowden, David J Hunter","doi":"10.1016/j.joca.2024.08.012","DOIUrl":"10.1016/j.joca.2024.08.012","url":null,"abstract":"<p><strong>Objective: </strong>To ascertain the comparative effectiveness of weight-loss strategies for osteoarthritis (OA) to develop rational treatment algorithms aimed at improving OA-related symptoms in overweight/obese individuals.</p><p><strong>Design: </strong>Medline, Embase, CINAHL, Scopus, and Web of Science were searched from inception to June 2023 for observational studies and randomized trials. Network meta-analyses were performed using a frequentist approach. Effect sizes for pain and function were computed as standardized mean differences, while change in body weight was computed as mean differences.</p><p><strong>Results: </strong>13 RCTs on knee OA (KOA) (2800 participants) with 7 interventions: diet (D); exercise (E); diet and exercise (DE); pharmacological (L); psychological (P); psychological, diet, and exercise (PDE); and Mediterranean diets (M) were networked. For weight change (kg), all interventions significantly outperformed control comparators, with effect sizes ranging from -11.2 (95% CI, -16.0, -6.5 kg) for the most effective approach (PDE) to -4.7 (95% CI, -6.7, -2.7 kg) for the least effective approach (DE). In terms of pain (0-20 scale), only DE outperformed control comparators (-2.2, 95% CI: -4.1, -0.21), whereas PDE was not superior to control comparators (-3.9, 95% CI: -8.4, 0.5) in improving the pain. Regardless of the chosen intervention, prediction intervals from meta-regression analysis indicate that significant pain relief may be anticipated when patients achieve at least a weight reduction of 7%.</p><p><strong>Conclusions: </strong>PDE and DE interventions may offer the most effective approach for weight loss, potentially leading to improvements in pain and physical function among overweight/obese individuals with KOA if they achieve more than 7% weight loss.</p>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knee braces for knee osteoarthritis: A scoping review and narrative synthesis of interventions in randomised controlled trials","authors":"MA Holden ,&nbsp;M. Murphy ,&nbsp;J. Simkins ,&nbsp;MJ Thomas ,&nbsp;L. Huckfield ,&nbsp;JG Quicke ,&nbsp;N. Halliday ,&nbsp;FN Birrell ,&nbsp;B. Borrelli ,&nbsp;MJ Callaghan ,&nbsp;K. Dziedzic ,&nbsp;D. Felson ,&nbsp;NE Foster ,&nbsp;C. Ingram ,&nbsp;C. Jinks ,&nbsp;S. Jowett ,&nbsp;E. Nicholls ,&nbsp;G. Peat","doi":"10.1016/j.joca.2024.08.010","DOIUrl":"10.1016/j.joca.2024.08.010","url":null,"abstract":"<div><h3>Objective</h3><div>To identify and synthesise the content of knee bracing interventions in randomised controlled trials (RCTs) of knee osteoarthritis (OA).</div></div><div><h3>Design</h3><div>In this scoping review, three electronic databases (PubMed, Web of Science, Cochrane) were searched up to 10th June 2024. Nineteen previous systematic reviews of knee bracing for knee OA and four recent international clinical practice guidelines were also hand searched. Identified studies were screened for eligibility by two independent reviewers. Information on bracing interventions was extracted from included RCT reports, informed by Template for Intervention Description and Replication (TIDieR) guidelines. Data were synthesised narratively.</div></div><div><h3>Results</h3><div>Thirty-one RCTs testing 47 different bracing interventions were included. Braces were broadly grouped as valgus/varus, patellofemoral, sleeve, neutral hinged, or control/placebo knee braces. Brace manufacturer and models varied, as did amount of recommended brace use. Only three interventions specifically targeted brace adherence. Information on brace providers, setting, number of treatment sessions, and intervention modification over time was poorly reported. Adherence to brace use was described for 32 (68%) interventions, most commonly via self-report. Several mechanisms of action for knee braces were proposed, broadly grouped as biomechanical, neuromuscular, and psychological.</div></div><div><h3>Conclusions</h3><div>Many different knee brace interventions have been tested for knee OA, with several proposed mechanisms of action, a lack of focus on adherence, and a lack of full reporting. These issues may be contributing to the heterogeneous findings and inconsistent guideline recommendations about the clinical effectiveness of knee bracing for knee OA to date.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"32 11","pages":"Pages 1371-1396"},"PeriodicalIF":7.2,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cereblon-AMPK (AMP-activated protein kinase) axis in chondrocytes regulates the pathogenesis of osteoarthritis","authors":"Yeon Lee,&nbsp;Hyo-Eun Kim,&nbsp;Ji-Sun Kwak,&nbsp;Chul-Seung Park,&nbsp;Jang-Soo Chun","doi":"10.1016/j.joca.2024.08.009","DOIUrl":"10.1016/j.joca.2024.08.009","url":null,"abstract":"<div><h3>Objective</h3><div>AMP-activated protein kinase (AMPK) dysregulation is implicated in osteoarthritis (OA), but the mechanisms underlying this dysregulation remain unclear. We investigated the role of cereblon, a substrate-recognition protein within the E3-ligase ubiquitin complex, in AMPK dysregulation and OA pathogenesis.</div></div><div><h3>Methods</h3><div>Cereblon expression was examined in human (n = 5) and mouse (n = 10) OA cartilage. The role of cereblon was investigated through its adenoviral overexpression (n = 10) or knockout (KO, n = 15) in the destabilization of the medial meniscus (DMM)-operated mice. The therapeutic potentials of the chemical cereblon degrader, TD-165, and the AMPK activator, metformin, were assessed through intra-articular (IA) injection to mice (n = 15).</div></div><div><h3>Results</h3><div>Immunostaining revealed that cereblon is upregulated in human and mouse OA cartilage. In DMM model mice, cartilage destruction was exacerbated by overexpression of cereblon in mouse joint tissues (OARSI grade; 1.11 [95% CI: 0.50 to 2.75]), but inhibited in global (−2.50 [95% CI: −3.00 to −1.17]) and chondrocyte-specific (−2.17 [95% CI: −3.14 to −1.06]) cereblon KO mice. The inhibitory effects were more pronounced in mice fed a high-fat diet compared to a regular diet. The degradation of cereblon through IA injection of TD-165 inhibited OA cartilage destruction (−2.47 [95% CI: −3.22 to −1.56]). Mechanistically, cereblon exerts its catabolic effects by negatively modulating AMPK activity within chondrocytes. Consistently, activation of AMPK by IA injection of metformin inhibited posttraumatic OA cartilage destruction (−1.20 ([95% CI: −1.89 to −0.45]).</div></div><div><h3>Conclusions</h3><div>The cereblon-AMPK axis acts as a catabolic regulator of OA pathogenesis and seems to be a promising therapeutic target in animal models of OA.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"32 12","pages":"Pages 1579-1590"},"PeriodicalIF":7.2,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The paravertebral lymphatic system is involved in the resorption of the herniated nucleus pulposus and the regression of inflammation associated with disc herniation","authors":"Yuanfei Fu ,&nbsp;Zhiming Lan ,&nbsp;Ning Li ,&nbsp;Lianping Xing ,&nbsp;Luying Yuan ,&nbsp;Juyi Lai ,&nbsp;Hualong Feng ,&nbsp;Lin Cong ,&nbsp;Yongjun Wang ,&nbsp;Shenghua He ,&nbsp;Qianqian Liang","doi":"10.1016/j.joca.2024.08.007","DOIUrl":"10.1016/j.joca.2024.08.007","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the role of the paravertebral lymphatic system in the nucleus pulposus herniation (NPH) resorption and the inflammation regression.</div></div><div><h3>Design</h3><div>Clinical specimens (n = 10) from patients with lumbar disc herniation (LDH) were collected, C57BL/6 (n = 84) and conditional Vegfr3 knockout mice (n = 14) were used. Immunofluorescence staining detected lymphatic vessels (LVs) and NP cells. Near-infrared imaging assessed lymphatic drainage function, and Alcian Blue/Orange determined inflammation.</div></div><div><h3>Results</h3><div>Lymphangiogenesis was observed in the herniated NP of patients with LDH, and the proportion of capillary LVs was higher than that of collecting LVs (mean 68.2% [95% confidence interval: 59.4, 77.1]). In NPH mice, NP cells were detected in paravertebral tissue (38.6 [32.0, 45.2]) and draining lymph nodes (dLN) at 4 h (76.9 [54.9, 98.8]). A significant increase of NP cells in dLNs was observed at 24 h (157.1 [113.7, 200.6]). Most of the herniated NP cells were cleared in paravertebral tissue after 1 week (7.5 [4.4, 10.6]), but disc inflammation peaked at 1 week (19.9% [14.7, 25.1]), along with persistent lymphangiogenesis (9.5 [7.2, 11.8]). However, conditional Vegfr3 knockout mice exhibited impaired lymphangiogenesis (5.7 [4.4, 7.0]) and herniated NP cell clearance (6.1 [1.8, 10.5]) during NPH, leading to exacerbated disc inflammation (23.7% [19.3, 28.2]).</div></div><div><h3>Conclusion</h3><div>The paravertebral lymphatic system is involved in the NPH resorption and inflammation regression. Promoting lymphangiogenesis may be a novel strategy for facilitating NPH resorption and inflammation regression in patients with LDH.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"32 12","pages":"Pages 1566-1578"},"PeriodicalIF":7.2,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}