Pub Date : 2025-02-01DOI: 10.1016/j.joca.2024.10.002
Sade W. Clayton, Remy E. Walk, Laura Mpofu, Garrett W.D. Easson, Simon Y. Tang
Objective
Inadequate repair of the intervertebral disc (IVD) contributes to low back pain. Infiltrating immune cells into damaged tissues are critical mediators of repair, yet little is known about the identities, roles, and temporal regulation following IVD injury. By analyzing transcripts of immune cell markers, histopathologic analysis, immunofluorescence, and flow cytometry, we aimed to define the temporal cascade of infiltrating immune cells and their associations with IVD degeneration.
Methods
Caudal IVDs from 12-week-old C57BL6/J mice were injured and monitored for 42 days post-injury. Transcriptional markers identifying myeloid, B, and T immune cells, and angiogenic factors were measured from the IVDs every 2–3 days. Histopathologic degeneration of the IVD was measured throughout. Flow cytometry and immunofluorescence were used to identify and localize cells including B, T, natural killer T (NKT) cells, monocytes, neutrophils, macrophages, eosinophils, and dendritic cells.
Results
The injured IVD revealed distinct phases of inflammation and proliferation. Robust temporal oscillation in the myeloid and T cell transcripts was observed in females. Cd3+ T cells were more abundant in females than in males. The Cd3+Cd4-Cd8- T cells that dominate the female cascade contain rare γδ T cells. Injury-mediated degeneration was prevalent in both sexes but more severe in males.
Conclusions
This study defines the coordinated infiltration of immune cells in the IVD following injury. We report the discovery of γδ T cells in the female IVD, and this was associated with less severe degeneration. γδ T cells have potent anti-inflammatory roles and may suppress degeneration following IVD injury.
目的椎间盘（IVD）修复不足是导致腰背痛的原因之一。向受损组织浸润的免疫细胞是修复的关键介质，但人们对 IVD 损伤后免疫细胞的身份、作用和时间调节却知之甚少。通过分析免疫细胞标记物转录本、组织病理学分析、免疫荧光和流式细胞术，我们旨在确定浸润免疫细胞的时间级联及其与 IVD 退化的关联。每隔 2-3 天测量一次 IVD 中识别髓系、B 和 T 免疫细胞的转录标记物以及血管生成因子。对 IVD 的组织病理学变性进行全程测量。流式细胞术和免疫荧光用于识别和定位细胞，包括 B、T、NKT、单核细胞、中性粒细胞、巨噬细胞和树突状细胞。在女性中观察到髓系细胞和 T 细胞转录本的强烈时间振荡。女性 Cd3+ T 细胞比男性更多。在雌性级联中占主导地位的 Cd3+Cd4-Cd8- T 细胞含有罕见的 γδ T 细胞。这项研究确定了损伤后免疫细胞在 IVD 中的协调浸润。我们报告在女性 IVD 中发现了 γδ T 细胞，这与较轻的退变有关。γδT细胞具有强大的抗炎作用，可抑制IVD损伤后的退化。
{"title":"Sex-specific divergences in the types and timing of infiltrating immune cells during the intervertebral disc acute injury response and their associations with degeneration","authors":"Sade W. Clayton, Remy E. Walk, Laura Mpofu, Garrett W.D. Easson, Simon Y. Tang","doi":"10.1016/j.joca.2024.10.002","DOIUrl":"10.1016/j.joca.2024.10.002","url":null,"abstract":"<div><h3>Objective</h3><div>Inadequate repair of the intervertebral disc (IVD) contributes to low back pain. Infiltrating immune cells into damaged tissues are critical mediators of repair, yet little is known about the identities, roles, and temporal regulation following IVD injury. By analyzing transcripts of immune cell markers, histopathologic analysis, immunofluorescence, and flow cytometry, we aimed to define the temporal cascade of infiltrating immune cells and their associations with IVD degeneration.</div></div><div><h3>Methods</h3><div>Caudal IVDs from 12-week-old C57BL6/J mice were injured and monitored for 42 days post-injury. Transcriptional markers identifying myeloid, B, and T immune cells, and angiogenic factors were measured from the IVDs every 2–3 days. Histopathologic degeneration of the IVD was measured throughout. Flow cytometry and immunofluorescence were used to identify and localize cells including B, T, natural killer T (NKT) cells, monocytes, neutrophils, macrophages, eosinophils, and dendritic cells.</div></div><div><h3>Results</h3><div>The injured IVD revealed distinct phases of inflammation and proliferation. Robust temporal oscillation in the myeloid and T cell transcripts was observed in females. Cd3+ T cells were more abundant in females than in males. The Cd3+Cd4-Cd8- T cells that dominate the female cascade contain rare γδ T cells. Injury-mediated degeneration was prevalent in both sexes but more severe in males.</div></div><div><h3>Conclusions</h3><div>This study defines the coordinated infiltration of immune cells in the IVD following injury. We report the discovery of γδ T cells in the female IVD, and this was associated with less severe degeneration. γδ T cells have potent anti-inflammatory roles and may suppress degeneration following IVD injury.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 2","pages":"Pages 247-260"},"PeriodicalIF":7.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.joca.2024.10.015
Danielle Howe , Jacob D. Thompson , Stephanie D. Teeter , Margaret Easson , Olivia Barlow , Emily H. Griffith , Lauren V. Schnabel , Jeffrey T. Spang , Matthew B. Fisher
Objective
Anterior cruciate ligament (ACL) injuries are a major problem in the pediatric and adolescent populations. Some of these injuries are only partial; yet, there is limited data to inform clinical treatment of such partial tears. It is unknown how injury partial injury impacts long-term degenerative changes in the joint relative to complete injury. In this study, we hypothesized that partial (anteromedial (AM) or posterolateral (PL) bundle) tears would result in small levels of instability and degeneration relative to complete ACL tears and that the degree of degeneration would associate with joint instability.
Design
Partial (isolated AM or PL bundle) or complete ACL injury was arthroscopically created in 3-month-old juvenile pigs. The contralateral limb served as a sham-operated control. Six months after injury, joint biomechanics was assessed along with cartilage and meniscus degeneration (via magnetic resonance imaging [MRI], gross imaging, and histology).
Results
Joint laxity increases were minimal after PL bundle injury (difference relative to controls (confidence interval): 0.5 (−1.2–2.2) mm), minor after AM bundle injury (3.7 (2.0–5.4) mm), and major after ACL injury (15.8 (13.7–17.8) mm). Cartilage MRI T1ρ relaxation times increased minimally after PL bundle injury (−0.9 (−5.1–3.3) ms for lateral tibia), moderately after AM bundle injury (6.6 (1.7–11.4) ms), and substantially after ACL injury (10.8 (2.1–19.5) ms). Changes in meniscus volume followed a similar rank order. Degeneration was associated with the extent of joint destabilization.
Conclusions
These findings suggest that cartilage and meniscus degeneration in the skeletally immature joint are associated with joint laxity after partial and complete ACL injuries.
{"title":"Early degenerative changes are different between partial and complete anterior cruciate ligament injury and associate with joint instability in a skeletally immature porcine model","authors":"Danielle Howe , Jacob D. Thompson , Stephanie D. Teeter , Margaret Easson , Olivia Barlow , Emily H. Griffith , Lauren V. Schnabel , Jeffrey T. Spang , Matthew B. Fisher","doi":"10.1016/j.joca.2024.10.015","DOIUrl":"10.1016/j.joca.2024.10.015","url":null,"abstract":"<div><h3>Objective</h3><div>Anterior cruciate ligament (ACL) injuries are a major problem in the pediatric and adolescent populations. Some of these injuries are only partial; yet, there is limited data to inform clinical treatment of such partial tears. It is unknown how injury partial injury impacts long-term degenerative changes in the joint relative to complete injury. In this study, we hypothesized that partial (anteromedial (AM) or posterolateral (PL) bundle) tears would result in small levels of instability and degeneration relative to complete ACL tears and that the degree of degeneration would associate with joint instability.</div></div><div><h3>Design</h3><div>Partial (isolated AM or PL bundle) or complete ACL injury was arthroscopically created in 3-month-old juvenile pigs. The contralateral limb served as a sham-operated control. Six months after injury, joint biomechanics was assessed along with cartilage and meniscus degeneration (via magnetic resonance imaging [MRI], gross imaging, and histology).</div></div><div><h3>Results</h3><div>Joint laxity increases were minimal after PL bundle injury (difference relative to controls (confidence interval): 0.5 (−1.2–2.2) mm), minor after AM bundle injury (3.7 (2.0–5.4) mm), and major after ACL injury (15.8 (13.7–17.8) mm). Cartilage MRI T1ρ relaxation times increased minimally after PL bundle injury (−0.9 (−5.1–3.3) ms for lateral tibia), moderately after AM bundle injury (6.6 (1.7–11.4) ms), and substantially after ACL injury (10.8 (2.1–19.5) ms). Changes in meniscus volume followed a similar rank order. Degeneration was associated with the extent of joint destabilization.</div></div><div><h3>Conclusions</h3><div>These findings suggest that cartilage and meniscus degeneration in the skeletally immature joint are associated with joint laxity after partial and complete ACL injuries.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 2","pages":"Pages 302-312"},"PeriodicalIF":7.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.joca.2024.10.010
F. Boel , J. Wortel , M.M.A. van Buuren , F. Rivadeneira , J.B.J. van Meurs , J. Runhaar , S.M.A. Bierma-Zeinstra , R. Agricola
Objective
Dual-energy x-ray absorptiometry (DXA) images are increasingly used to study hip morphology. Whether hip morphology measurements are consistent between DXA images and radiographs is unknown. Therefore, we investigated the agreement and reliability of the measurements performed on DXA images and radiographs.
Design
We included participants from the Rotterdam study, a population-based cohort study, who received a hip DXA image and pelvic radiograph on the same day. The acetabular depth-width ratio (ADR), modified acetabular index (mAI), alpha angle (AA), Wiberg and lateral center edge angle (WCEA, LCEA), extrusion index (EI) and triangular index ratio (TIR) were automatically determined on both imaging modalities. The intraobserver and intermethod agreement were studied using Bland-Altman methods, and the reliability was assessed using intraclass correlation coefficients (ICC). Secondly, the diagnostic agreement regarding dysplasia, cam, and pincer morphology was assessed using percent agreement and Cohen’s kappa.
Results
A total of 750 hips from 411 individuals, median age 67.3 years (range 52.2 – 90.6), 45.5% male, were included. The following intermethod ICCs (95% CI) were obtained: ADR 0.85 (0.74–0.91), mAI 0.75 (0.52–0.85), AA 0.72 (0.68–0.75), WCEA 0.81 (0.74–0.85), LCEA 0.93 (0.91–0.94), EI 0.88 (0.84–0.91), and TIR 0.81 (0.79–0.84). We found comparable intraobserver ICCs for each morphological measurement.
Conclusion
DXA images and pelvic radiographs could both reliably be used to study hip morphology. Due to the lower radiation burden, DXA images could be an excellent alternative to pelvic radiographs for research purposes.
{"title":"DXA images vs. pelvic radiographs: Reliability of hip morphology measurements","authors":"F. Boel , J. Wortel , M.M.A. van Buuren , F. Rivadeneira , J.B.J. van Meurs , J. Runhaar , S.M.A. Bierma-Zeinstra , R. Agricola","doi":"10.1016/j.joca.2024.10.010","DOIUrl":"10.1016/j.joca.2024.10.010","url":null,"abstract":"<div><h3>Objective</h3><div>Dual-energy x-ray absorptiometry (DXA) images are increasingly used to study hip morphology. Whether hip morphology measurements are consistent between DXA images and radiographs is unknown. Therefore, we investigated the agreement and reliability of the measurements performed on DXA images and radiographs.</div></div><div><h3>Design</h3><div>We included participants from the Rotterdam study, a population-based cohort study, who received a hip DXA image and pelvic radiograph on the same day. The acetabular depth-width ratio (ADR), modified acetabular index (mAI), alpha angle (AA), Wiberg and lateral center edge angle (WCEA, LCEA), extrusion index (EI) and triangular index ratio (TIR) were automatically determined on both imaging modalities. The intraobserver and intermethod agreement were studied using Bland-Altman methods, and the reliability was assessed using intraclass correlation coefficients (ICC). Secondly, the diagnostic agreement regarding dysplasia, cam, and pincer morphology was assessed using percent agreement and Cohen’s kappa.</div></div><div><h3>Results</h3><div>A total of 750 hips from 411 individuals, median age 67.3 years (range 52.2 – 90.6), 45.5% male, were included. The following intermethod ICCs (95% CI) were obtained: ADR 0.85 (0.74–0.91), mAI 0.75 (0.52–0.85), AA 0.72 (0.68–0.75), WCEA 0.81 (0.74–0.85), LCEA 0.93 (0.91–0.94), EI 0.88 (0.84–0.91), and TIR 0.81 (0.79–0.84). We found comparable intraobserver ICCs for each morphological measurement.</div></div><div><h3>Conclusion</h3><div>DXA images and pelvic radiographs could both reliably be used to study hip morphology. Due to the lower radiation burden, DXA images could be an excellent alternative to pelvic radiographs for research purposes.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 2","pages":"Pages 283-292"},"PeriodicalIF":7.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.joca.2024.10.013
Sietse E.S. Terpstra , Lotte A. van de Stadt , Annelies Boonen , Rolf H.H. Groenwold , Frits R. Rosendaal , Margreet Kloppenburg
Objectives
To investigate the course of restrictions in paid and unpaid work and corresponding societal costs in patients with hand osteoarthritis (OA).
Methods
Patients with data of at least baseline and one follow-up moment (year one up to year eight) of the Dutch Hand OSTeoArthritis in Secondary care cohort (HOSTAS) were included. The Health and Labour Questionnaire was used to assess over the last two weeks hand OA-related restrictions for paid and unpaid work. Societal costs of productivity loss were estimated with Dutch government data on 2021.
Results
351 patients were included (mean age 60 years, 84% women). At baseline, 166/351 (47%) had paid work, decreasing to 54/164 (33%) at year eight. Loss of productive time over the two-week period was reported by 32/166 (19%) patients with paid work at baseline, 17/104 (16%) at year four, among whom 12/104 (11%) patients at both moments. Any restrictions over this two-week period were experienced by 89/166 patients (54%) at baseline and 41/104 (39%) at year four for those with paid work.
Regarding unpaid work, 157/351 (45%) reported replacement of tasks by others at baseline and 72/164 (44%) at year eight. 205/351 (59%) reported restrictions at baseline, and 99/164 (60%) at year eight.
Mean total societal costs for loss of paid and unpaid work were, per patient, €89/two weeks (95% confidence interval 52;127) at baseline and €47/two weeks (26;69) at year eight.
Conclusions
The proportion of patients with paid work decreases during follow-up, but restrictions at paid and unpaid work seem mostly stable.
{"title":"The longitudinal association of hand osteoarthritis with paid and unpaid work restrictions and related societal costs: The Hand Osteoarthritis in Secondary Care cohort","authors":"Sietse E.S. Terpstra , Lotte A. van de Stadt , Annelies Boonen , Rolf H.H. Groenwold , Frits R. Rosendaal , Margreet Kloppenburg","doi":"10.1016/j.joca.2024.10.013","DOIUrl":"10.1016/j.joca.2024.10.013","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the course of restrictions in paid and unpaid work and corresponding societal costs in patients with hand osteoarthritis (OA).</div></div><div><h3>Methods</h3><div>Patients with data of at least baseline and one follow-up moment (year one up to year eight) of the Dutch Hand OSTeoArthritis in Secondary care cohort (HOSTAS) were included. The Health and Labour Questionnaire was used to assess over the last two weeks hand OA-related restrictions for paid and unpaid work. Societal costs of productivity loss were estimated with Dutch government data on 2021.</div></div><div><h3>Results</h3><div>351 patients were included (mean age 60 years, 84% women). At baseline, 166/351 (47%) had paid work, decreasing to 54/164 (33%) at year eight. Loss of productive time over the two-week period was reported by 32/166 (19%) patients with paid work at baseline, 17/104 (16%) at year four, among whom 12/104 (11%) patients at both moments. Any restrictions over this two-week period were experienced by 89/166 patients (54%) at baseline and 41/104 (39%) at year four for those with paid work.</div><div>Regarding unpaid work, 157/351 (45%) reported replacement of tasks by others at baseline and 72/164 (44%) at year eight. 205/351 (59%) reported restrictions at baseline, and 99/164 (60%) at year eight.</div><div>Mean total societal costs for loss of paid and unpaid work were, per patient, €89/two weeks (95% confidence interval 52;127) at baseline and €47/two weeks (26;69) at year eight.</div></div><div><h3>Conclusions</h3><div>The proportion of patients with paid work decreases during follow-up, but restrictions at paid and unpaid work seem mostly stable.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 2","pages":"Pages 293-301"},"PeriodicalIF":7.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-31DOI: 10.1016/j.joca.2025.01.002
L K King, J W Liew, A Mahmoudian, Q Wang, N E J Jansen, I Stanaitis, V Hung, F Berenbaum, S Das, C Ding, C A Emery, S R Filbay, M C Hochberg, M Ishijima, M Kloppenburg, N E Lane, E Losina, A Mobasheri, A Turkiewicz, J Runhaar, I K Haugen, C T Appleton, L S Lohmander, M Englund, T Neogi, G A Hawker
{"title":"Corrigendum to \"Multi-centre modified Delphi exercise to identify candidate items for classifying early-stage symptomatic knee osteoarthritis\" [Osteoarthritis Cartilage (2025) 155-165].","authors":"L K King, J W Liew, A Mahmoudian, Q Wang, N E J Jansen, I Stanaitis, V Hung, F Berenbaum, S Das, C Ding, C A Emery, S R Filbay, M C Hochberg, M Ishijima, M Kloppenburg, N E Lane, E Losina, A Mobasheri, A Turkiewicz, J Runhaar, I K Haugen, C T Appleton, L S Lohmander, M Englund, T Neogi, G A Hawker","doi":"10.1016/j.joca.2025.01.002","DOIUrl":"https://doi.org/10.1016/j.joca.2025.01.002","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-31DOI: 10.1016/j.joca.2024.12.009
International Foot and Ankle Osteoarthritis Consortium, Hylton B. Menz, Shannon Munteanu, Kade Paterson, Yvonne Golightly, Catherine Bowen, Marian Hannan, Lara Chapman
To conduct a bibliographic analysis of English language, non-surgical research pertaining to foot osteoarthritis (OA).
{"title":"Foot osteoarthritis research: A bibliometric analysis","authors":"International Foot and Ankle Osteoarthritis Consortium, Hylton B. Menz, Shannon Munteanu, Kade Paterson, Yvonne Golightly, Catherine Bowen, Marian Hannan, Lara Chapman","doi":"10.1016/j.joca.2024.12.009","DOIUrl":"https://doi.org/10.1016/j.joca.2024.12.009","url":null,"abstract":"To conduct a bibliographic analysis of English language, non-surgical research pertaining to foot osteoarthritis (OA).","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"24 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-27DOI: 10.1016/j.joca.2025.01.001
Gabby B Joseph, Felix Liu, Katharina Ziegeler, Zehra Akkaya, John A Lynch, Valentina Pedoia, Sharmila Majumdar, Nancy E Lane, Michael C Nevitt, Charles E McCulloch, Thomas M Link
Objective: Knee-adjacent subcutaneous fat (kaSCF) has emerged as a potential biomarker and risk factor for osteoarthritis (OA) progression. This study aims to develop an artificial intelligence-based tool for the automatic segmentation of kaSCF thickness and evaluate the cross-sectional associations between kaSCF, cartilage thickness, magnetic resonance imaging-based cartilage T2 relaxation time, knee pain, and muscle strength independent of body mass index (BMI).
Design: Baseline 3.0T MR images of the right knee from the entire Osteoarthritis Initiative cohort (n=4796) were used to quantify average values of kaSCF, cartilage thickness, and T2 using deep learning algorithms. Regression models (adjusted for age, gender, BMI, and race) were used to evaluate the associations between standardized kaSCF and outcomes of cartilage thickness, T2, pain, and knee extension strength.
Results: Model prediction CVs for kaSCF thickness ranged from 3.57% to 9.87% across femoral and tibial regions. Greater average kaSCF was associated with thinner cartilage in men (std. β= -0.029, 95% CI: -0.050 to -0.007, p=0.010) and higher T2 in women (std. β=0.169, 95% CI: 0.072 to 0.265, p=0.001). Greater kaSCF was also associated with lower knee extension force (std. β= -15.36, 95% CI: -20.39 to -10.33, p<0.001) and higher odds of frequent knee pain (std. odds ratio=1.156, 95% CI: 1.046 to 1.278, p=0.005) across all participants.
Conclusions: Greater kaSCF was associated with thinner cartilage in men, higher T2 in women, reduced knee strength, and greater knee pain, independent of BMI. These findings suggest a potential role of kaSCF as a predictor for knee osteoarthrits-related structural, functional, and clinical outcomes independent of the effects of BMI.
{"title":"Quantifying knee-adjacent subcutaneous fat in the entire OAI baseline dataset - Associations with cartilage MRI T<sub>2</sub>, thickness and pain, independent of BMI.","authors":"Gabby B Joseph, Felix Liu, Katharina Ziegeler, Zehra Akkaya, John A Lynch, Valentina Pedoia, Sharmila Majumdar, Nancy E Lane, Michael C Nevitt, Charles E McCulloch, Thomas M Link","doi":"10.1016/j.joca.2025.01.001","DOIUrl":"10.1016/j.joca.2025.01.001","url":null,"abstract":"<p><strong>Objective: </strong>Knee-adjacent subcutaneous fat (kaSCF) has emerged as a potential biomarker and risk factor for osteoarthritis (OA) progression. This study aims to develop an artificial intelligence-based tool for the automatic segmentation of kaSCF thickness and evaluate the cross-sectional associations between kaSCF, cartilage thickness, magnetic resonance imaging-based cartilage T<sub>2</sub> relaxation time, knee pain, and muscle strength independent of body mass index (BMI).</p><p><strong>Design: </strong>Baseline 3.0T MR images of the right knee from the entire Osteoarthritis Initiative cohort (n=4796) were used to quantify average values of kaSCF, cartilage thickness, and T<sub>2</sub> using deep learning algorithms. Regression models (adjusted for age, gender, BMI, and race) were used to evaluate the associations between standardized kaSCF and outcomes of cartilage thickness, T<sub>2</sub>, pain, and knee extension strength.</p><p><strong>Results: </strong>Model prediction CVs for kaSCF thickness ranged from 3.57% to 9.87% across femoral and tibial regions. Greater average kaSCF was associated with thinner cartilage in men (std. β= -0.029, 95% CI: -0.050 to -0.007, p=0.010) and higher T<sub>2</sub> in women (std. β=0.169, 95% CI: 0.072 to 0.265, p=0.001). Greater kaSCF was also associated with lower knee extension force (std. β= -15.36, 95% CI: -20.39 to -10.33, p<0.001) and higher odds of frequent knee pain (std. odds ratio=1.156, 95% CI: 1.046 to 1.278, p=0.005) across all participants.</p><p><strong>Conclusions: </strong>Greater kaSCF was associated with thinner cartilage in men, higher T<sub>2</sub> in women, reduced knee strength, and greater knee pain, independent of BMI. These findings suggest a potential role of kaSCF as a predictor for knee osteoarthrits-related structural, functional, and clinical outcomes independent of the effects of BMI.</p>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-24DOI: 10.1016/j.joca.2025.01.004
Arashi Shahid, Aricia Jieqi Thirumaran, Robin Christensen, Venkatesha Venkatesha, Marius Henriksen, Jocelyn L. Bowden, David J. Hunter
{"title":"Corrigendum to Comparison of weight loss interventions in overweight and obese adults with knee osteoarthritis: A systematic review and network meta-analysis of randomized trials [Osteoarthritis Cartilage (2024)]","authors":"Arashi Shahid, Aricia Jieqi Thirumaran, Robin Christensen, Venkatesha Venkatesha, Marius Henriksen, Jocelyn L. Bowden, David J. Hunter","doi":"10.1016/j.joca.2025.01.004","DOIUrl":"https://doi.org/10.1016/j.joca.2025.01.004","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"10 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-22DOI: 10.1016/j.joca.2024.12.008
Masumeh Kazemi, Chenhao Yu, Dev R. Mehrotra, Erik E. Ersland, Stefan Zbyn, Farida Korna, Steven J. Staffa, Julie B. Engiles, Xiaojuan Li, Thomas P. Schaer, Mark W. Grinstaff, Mads S. Bergholt, Brian D. Snyder, Michael B. Albro
The diagnosis of early osteoarthritis when therapeutic interventions may be most effective at reversing cartilage degeneration presents a clinical challenge. We describe a Raman arthroscopic probe and spectral analysis that measures biomarkers reflective of the content of predominant cartilage ECM constituents—glycosaminoglycans (GAG), collagen, water—essential to cartilage function. We compare the capability of Raman-probe-derived biomarkers to predict functional properties of cartilage to quantitative MRI and histopathology assessments.
{"title":"Raman spectroscopic probe provides optical biomarkers of cartilage composition predictive of tissue function","authors":"Masumeh Kazemi, Chenhao Yu, Dev R. Mehrotra, Erik E. Ersland, Stefan Zbyn, Farida Korna, Steven J. Staffa, Julie B. Engiles, Xiaojuan Li, Thomas P. Schaer, Mark W. Grinstaff, Mads S. Bergholt, Brian D. Snyder, Michael B. Albro","doi":"10.1016/j.joca.2024.12.008","DOIUrl":"https://doi.org/10.1016/j.joca.2024.12.008","url":null,"abstract":"The diagnosis of early osteoarthritis when therapeutic interventions may be most effective at reversing cartilage degeneration presents a clinical challenge. We describe a Raman arthroscopic probe and spectral analysis that measures biomarkers reflective of the content of predominant cartilage ECM constituents—glycosaminoglycans (GAG), collagen, water—essential to cartilage function. We compare the capability of Raman-probe-derived biomarkers to predict functional properties of cartilage to quantitative MRI and histopathology assessments.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"49 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-22DOI: 10.1016/j.joca.2024.12.010
Minerva Nong, Medha Barbhaiya, Genna Braverman, Vivian P Bykerk, Nathaniel Hupert, Colby Lewis, Lisa A Mandl
Objective: People with osteoarthritis (OA) commonly experience flares. Whether COVID-19 vaccination triggers OA flares is unknown.
Design: Adults with OA enrolled in a COVID-19 Rheumatology Registry were invited to participate in a case-crossover study. Vaccine data were ascertained from self-report and electronic health records (EHR). OA was identified using coding algorithms and validated via EHR. Participants reported flare and non-flare periods. Vaccine exposures in the 2-, 7-, and 14-day "lookback windows" prior to OA flares were compared to vaccine exposures during similar non-flare ("control") periods.
Results: 279 participants had validated OA, and 136 (49%) contributed at least one flare and one control period. Mean age was 68 years [SD ±8], 82% female, 87% White, 62% knee OA, 56% hip OA, 37% hand/wrist OA and 60% had >= one anatomic location of OA. 525 COVID-19 vaccine doses were recorded, and participants reported 374 OA flares: 30% were mild, 55% were moderate, and 14% were severe. OA flares were not associated with COVID-19 vaccination 2 or 7 days prior (odds ratios [OR] 0.69 [95% confidence interval (CI): 0.28, 1.66], OR 0.54 [95% CI: 0.27, 1.07], respectively). In the 14-day lookback window, fewer flares occurred after vaccination (OR 0.57 [95% CI: 0.34, 0.97], p=0.039). Analyses stratified on sex, age, knee or hand OA, vaccine brand, and dose showed no increased association between COVID-19 vaccination and OA flares.
Conclusion: The lack of positive association between COVID-19 vaccination and OA flare in any primary or secondary analysis provides reassurance regarding the use of COVID-19 vaccines in people with OA.
{"title":"Association of COVID-19 vaccinations with osteoarthritis flares: A case-crossover study.","authors":"Minerva Nong, Medha Barbhaiya, Genna Braverman, Vivian P Bykerk, Nathaniel Hupert, Colby Lewis, Lisa A Mandl","doi":"10.1016/j.joca.2024.12.010","DOIUrl":"10.1016/j.joca.2024.12.010","url":null,"abstract":"<p><strong>Objective: </strong>People with osteoarthritis (OA) commonly experience flares. Whether COVID-19 vaccination triggers OA flares is unknown.</p><p><strong>Design: </strong>Adults with OA enrolled in a COVID-19 Rheumatology Registry were invited to participate in a case-crossover study. Vaccine data were ascertained from self-report and electronic health records (EHR). OA was identified using coding algorithms and validated via EHR. Participants reported flare and non-flare periods. Vaccine exposures in the 2-, 7-, and 14-day \"lookback windows\" prior to OA flares were compared to vaccine exposures during similar non-flare (\"control\") periods.</p><p><strong>Results: </strong>279 participants had validated OA, and 136 (49%) contributed at least one flare and one control period. Mean age was 68 years [SD ±8], 82% female, 87% White, 62% knee OA, 56% hip OA, 37% hand/wrist OA and 60% had >= one anatomic location of OA. 525 COVID-19 vaccine doses were recorded, and participants reported 374 OA flares: 30% were mild, 55% were moderate, and 14% were severe. OA flares were not associated with COVID-19 vaccination 2 or 7 days prior (odds ratios [OR] 0.69 [95% confidence interval (CI): 0.28, 1.66], OR 0.54 [95% CI: 0.27, 1.07], respectively). In the 14-day lookback window, fewer flares occurred after vaccination (OR 0.57 [95% CI: 0.34, 0.97], p=0.039). Analyses stratified on sex, age, knee or hand OA, vaccine brand, and dose showed no increased association between COVID-19 vaccination and OA flares.</p><p><strong>Conclusion: </strong>The lack of positive association between COVID-19 vaccination and OA flare in any primary or secondary analysis provides reassurance regarding the use of COVID-19 vaccines in people with OA.</p>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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