Osteoarthritis and Cartilage最新文献

英文中文

Methodological gaps in air pollution and osteoarthritis risk research 空气污染与骨关节炎风险研究的方法学空白

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.06.010

Peng-yan Qiao , Yan-li Yang , Jun-kang Zhao , Ping-zhi Wang , James Cheng-Chung Wei , Li-yun Zhang

引用次数: 0

Response to letter regarding “A decade of exposure: Long-term air pollution and its impact on osteoarthritis: A nationwide cohort study in Taiwan” 对“十年暴露：长期空气污染及其对骨关节炎的影响：台湾一项全国性队列研究”的回复。

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.07.009

Yi-Chuan Chan , Yen-Wei Huang , Shu-Han Chuang, Yi-Jie Kuo, Yu-Pin Chen

引用次数: 0

PTHrP signalling-dependent rehabilitative effects on CD90-expressing chondrocytes PTHrP信号依赖性对表达cd90的软骨细胞的康复作用。

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.10.004

Lingfeng Xu , Yuejiao Zhang , Hongxu Yang , Jing Zhang , Qian Liu , Jiali Xu , Peinan Fan , Jia Yu , Peng Zhou , Xiaojie Xu , Wanqiu Huo , Mian Zhang , Lei Lu , Shibin Yu , Yaoping Wu , Meiqing Wang

Objective

To investigate the parathyroid hormone-related peptide (PTHrP) nuclear localisation segment (PTHrP-NLS) and parathyroid hormone 1 receptor (PTH1R) signal-dependent rehabilitative effects of CD90⁺ chondrocytes (CD90-CCs) on degenerative temporomandibular joint (TMJ) cartilage.

Design

Changes in PTHrP and PTH1R expression in CD90-CCs in TMJ cartilage in response to bilateral anterior elevation (BAE), which promotes TMJ cartilage thickening, were measured in female mice. A genetic modulation strategy was adopted. CD90-CCs were isolated from PTHrP-NLS conditional mutation (CD90-CreER;Pthlh^84STOP) mice, PTH1R conditional mutation (CD90-CreER;Pth1r^-/-) mice, human osteoarthritic knee cartilage (7 surgery operation donors) and rat osteoarthritic TMJ cartilage. These isolated CD90-CCs were cultured, amplified, and then injected into the experimental osteoarthritic TMJ, which was induced by the unilateral anterior crossbite (UAC) method, to evaluate the rehabilitative effect of the CD90-CCs (all, n = 6).

Results

BAE increased the TMJ cartilage thickness and the expression of PTHrP and PTH1R. The cartilage thickening effect of BAE was retarded in PTHrP conditional mutation (CD90-CreER;Pthlh^-/-) mice and CD90-CreER;Pth1r^-/- mice. Local injections of CD90-CCs reversed 62.96% of the UAC-induced cartilage loss [95% CI: (46.93%, 78.99%)], whereas the rescue effect of CD90-CCs derived from CD90-CreER;Pthlh^84STOP mice and CD90-CreER;Pth1r^-/- mice was limited. CD90-CCs from osteoarthritic TMJ cartilage and osteoarthritic knee cartilage, both of which express PTHrP and PTH1R, also produced rehabilitative effects.

Conclusions

The restorative effects of CD90-CCs on cartilage are controlled by PTHrP-NLS and PTH1R signalling. Autologous infusion of sufficient numbers of expanded PTHrP and PTH1R dual signal-positive CD90-CCs could be a new strategy for treating joints with osteoarthritic cartilage.

目的探讨甲状旁腺激素相关肽（PTHrP）核定位段（PTHrP- nls）和甲状旁腺激素1受体（PTH1R）信号依赖的CD90+软骨细胞（CD90- ccs）对退行性颞下颌关节（TMJ）软骨的康复作用。设计在雌性小鼠中测量双侧前抬高（BAE）促进TMJ软骨增厚时TMJ软骨CD90-CCs中PTHrP和PTH1R表达的变化。采用遗传调制策略。从PTHrP-NLS条件突变（CD90-CreER;Pthlh84STOP）小鼠、PTH1R条件突变（CD90-CreER; PTH1R -/-）小鼠、人骨关节炎膝关节软骨（7例手术供体）和大鼠骨关节炎TMJ软骨中分离CD90-CCs。将这些分离的CD90-CCs进行培养、扩增，然后注射到单侧前交叉牙合（UAC）法诱导的实验性骨关节炎TMJ中，以评估CD90-CCs的康复效果（均为n = 6）。结果bae可增加颞下颌关节软骨厚度，增加PTHrP和PTH1R的表达。在PTHrP条件突变（CD90-CreER;Pthlh-/-）小鼠和CD90-CreER中，BAE的软骨增厚作用被延缓；Pth1r - / -小鼠。局部注射CD90-CCs逆转了62.96%的uac诱导的软骨损失[95% CI:(46.93%, 78.99%)]，而CD90-CCs的拯救作用来源于CD90-CreER；Pthlh84STOP小鼠与CD90-CreER；Pth1r-/-小鼠数量有限。来自骨关节炎的TMJ软骨和膝关节软骨的cd90 - cc，均表达PTHrP和PTH1R，也具有康复作用。结论CD90-CCs对软骨的修复作用受PTHrP-NLS和PTH1R信号的调控。自体输注足够数量的PTHrP和PTH1R双信号阳性cd90 - cc可能是治疗骨关节炎软骨关节的新策略。数据可用性STATEMENTData可用于学术，非商业研究目的，在合理的要求下，进入适当的数据访问协议，并受到任何适用的伦理批准。支持本研究结果的数据可应要求从通讯作者处获得。

{"title":"PTHrP signalling-dependent rehabilitative effects on CD90-expressing chondrocytes","authors":"Lingfeng Xu , Yuejiao Zhang , Hongxu Yang , Jing Zhang , Qian Liu , Jiali Xu , Peinan Fan , Jia Yu , Peng Zhou , Xiaojie Xu , Wanqiu Huo , Mian Zhang , Lei Lu , Shibin Yu , Yaoping Wu , Meiqing Wang","doi":"10.1016/j.joca.2025.10.004","DOIUrl":"10.1016/j.joca.2025.10.004","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the parathyroid hormone-related peptide (PTHrP) nuclear localisation segment (PTHrP-NLS) and parathyroid hormone 1 receptor (PTH1R) signal-dependent rehabilitative effects of CD90<sup>+</sup> chondrocytes (CD90-CCs) on degenerative temporomandibular joint (TMJ) cartilage.</div></div><div><h3>Design</h3><div>Changes in PTHrP and PTH1R expression in CD90-CCs in TMJ cartilage in response to bilateral anterior elevation (BAE), which promotes TMJ cartilage thickening, were measured in female mice. A genetic modulation strategy was adopted. CD90-CCs were isolated from PTHrP-NLS conditional mutation (<em>CD90</em>-CreER;<em>Pthlh</em><sup>84STOP</sup>) mice, PTH1R conditional mutation (<em>CD90</em>-CreER;<em>Pth1r</em><sup><em>-/-</em></sup>) mice, human osteoarthritic knee cartilage (7 surgery operation donors) and rat osteoarthritic TMJ cartilage. These isolated CD90-CCs were cultured, amplified, and then injected into the experimental osteoarthritic TMJ, which was induced by the unilateral anterior crossbite (UAC) method, to evaluate the rehabilitative effect of the CD90-CCs (all, <em>n</em> = 6).</div></div><div><h3>Results</h3><div>BAE increased the TMJ cartilage thickness and the expression of PTHrP and PTH1R. The cartilage thickening effect of BAE was retarded in PTHrP conditional mutation (<em>CD90</em>-CreER;<em>Pthlh</em><sup><em>-/-</em></sup>) mice and <em>CD90</em>-CreER;<em>Pth1r</em><sup><em>-/-</em></sup> mice. Local injections of CD90-CCs reversed 62.96% of the UAC-induced cartilage loss [95% CI: (46.93%, 78.99%)], whereas the rescue effect of CD90-CCs derived from <em>CD90</em>-CreER;<em>Pthlh</em><sup>84STOP</sup> mice and <em>CD90</em>-CreER;<em>Pth1r</em><sup><em>-/-</em></sup> mice was limited. CD90-CCs from osteoarthritic TMJ cartilage and osteoarthritic knee cartilage, both of which express PTHrP and PTH1R, also produced rehabilitative effects.</div></div><div><h3>Conclusions</h3><div>The restorative effects of CD90-CCs on cartilage are controlled by PTHrP-NLS and PTH1R signalling. Autologous infusion of sufficient numbers of expanded PTHrP and PTH1R dual signal-positive CD90-CCs could be a new strategy for treating joints with osteoarthritic cartilage.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 1","pages":"Pages 82-92"},"PeriodicalIF":9.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The burden of osteoarthritis: Lifespan matters 骨关节炎的负担：寿命问题

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.10.017

Francisco A.C. Rocha

引用次数: 0

Effects of pre- and postsurgery physical activity interventions on physical activity and sedentary behavior levels following knee and hip arthroplasty: A systematic review and meta-analysis of randomized controlled trials 致编辑的信：术前和术后体育活动干预对膝关节和髋关节置换术后体育活动和久坐行为水平的影响：随机对照试验的系统回顾和荟萃分析。

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.09.003

Ruhui Yang , Haimin Zeng , Jie Peng , Bofan Chen , Liang Hao

引用次数: 0

Association of ligament mechanical properties and articular surface topography with trapeziometacarpal kinematics across osteoarthritis stages 韧带力学特性和关节表面形貌与骨关节炎不同阶段的梯形腕关节运动学的关系

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.10.019

Daniel Gordon , Shuchun Sun , Lizzie Walker , Nathan Buchweitz , Jichao Zhao , Eugene Mah , Claire Sumwalt , Jay Baek , Kiarra Blake-Wade , Nicholas Bain , Elizabeth Slate , Alexander Chiaramonti , Dane Daley , Hai Yao , Yongren Wu

Objective

The trapeziometacarpal (TMC) joint, a common site of osteoarthritis (OA) in postmenopausal women, relies on ligamentous structures for stability due to minimal bony constraint. However, the role of ligamentous constraint in OA pathomechanics, specifically its relationship with joint kinematics and surface morphology across disease stages, remains poorly understood.

Method

Forty-six cadaveric female TMC joints across OA stages were analyzed. Articular surface topography was assessed via space distance, curvedness, congruence, and global curvature. Kinematics were recorded via 3D motion tracking of cadaveric hand tasks, examining first metacarpal motion. Ligament mechanical properties were quantified through stress-relaxation and pull-to-failure testing. Specimens were grouped using principal component analysis (PCA) and K-means clustering.

Results

Three clusters emerged: Cluster 1 (healthy bone, kinematics, ligament), Cluster 2 (mild surface remodeling, excess range-of-motion (ROM)/unstable kinematics, attenuated ligament), and Cluster 3 (remodeled surface, reduced ROM, degenerated ligament). Cluster analysis showed topographical changes, with reduced metacarpal ulnar-radial global curvature in Cluster 3. ROM increased from Cluster 1–2 and decreased significantly from Cluster 2–3. Ligament data revealed volar ligament complex (VLC) attenuation and minor dorsal radial ligament (DRL) attenuation from Cluster 1–2, and from Cluster 2–3.

Conclusions

This study suggests a relationship between ligament mechanics, articular surface topography, and joint kinematics. Clustering revealed links between VLC attenuation and kinematics in early OA. Age and Eaton-Littler classification captured late-stage topographic changes but was less sensitive to ligament mechanics and kinematics. Incorporating ligament mechanics and kinematics may reveal dysfunction missed by current grading systems.

目的：绝经后女性骨关节炎（OA）的常见部位——斜跖骨（TMC）关节的稳定性依赖于韧带结构，因为其骨约束最小。然而，韧带约束在OA病理力学中的作用，特别是它与关节运动学和关节表面形态在疾病分期的关系，仍然知之甚少。方法对46例女性尸体TMC关节进行骨关节炎分期分析。关节表面形貌通过空间距离、弯曲度、同余度和整体曲率来评估。运动学记录通过三维运动跟踪尸体手任务，检查第一掌骨运动。通过应力松弛和拉至失效测试量化韧带力学性能。采用主成分分析（PCA）和K-means聚类对标本进行分组。结果出现了3个集群：集群1（健康骨骼，运动学，韧带），集群2（轻度表面重塑，过度运动范围(ROM)/不稳定运动，韧带减弱），集群3（重塑表面，ROM减少，韧带退化）。聚类分析显示地形变化，聚类3中掌骨尺桡整体曲率减小。从集群1-2开始，ROM增加，从集群2-3开始，ROM显著减少。韧带数据显示掌侧韧带复合体（VLC）衰减和轻微的径向背韧带（DRL）衰减来自集群1-2和集群2-3。结论本研究提示了韧带力学、关节表面形貌和关节运动学之间的关系。聚类揭示了早期OA中VLC衰减与运动学之间的联系。年龄和伊顿-利特勒分类捕捉晚期地形变化，但对韧带力学和运动学不太敏感。结合韧带力学和运动学可以揭示当前分级系统所遗漏的功能障碍。

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引用次数: 0

Contextualizing unnormalized vertical ground reaction force and knee osteoarthritis: Association does not imply mechanical causation 情境化非标准化垂直地面反作用力与膝关节OA：关联并不意味着机械因果关系。

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.09.017

Karl Morgan

引用次数: 0

Age- and sex-specific knee alignment patterns in symptomatic Korean patients: A cross-sectional deep learning analysis of 16,000 knees 有症状的韩国患者的年龄和性别特异性膝关节排列模式：对16,000个膝关节的横断面深度学习分析。

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.10.011

Hong-Seon Lee , Se-Han Jung , Seung-hyun Song , Chaeri Park , Young Han Lee , Sung-Hwan Kim , Sangchul Hwang , Sungjun Kim

Objective

To analyze age- and sex-specific associations in knee alignment using a large dataset of long-leg radiographs with deep learning-based automated measurements.

Methods

This retrospective cross-sectional study included 8014 radiographs (16,028 knees) from symptomatic adults who underwent long-leg radiography at a tertiary hospital in South Korea (2010–2023). Alignment parameters, including mechanical tibiofemoral angle (MTFA), lateral distal femoral angle (LDFA), medial proximal tibial angle (MPTA), and joint line convergence angle (JLCA), were automatically extracted using a deep learning model. Linear regression assessed age-related associations stratified by sex and age group (<50 years versus ≥50 years), adjusting for body mass index, Kellgren–Lawrence grade, and clinical indication.

Results

After adjustment, age-related associations in knee alignment differed by sex and age group. MTFA increased with age, most prominently in women aged ≥50 years (right/left β = 0.053/0.040 degrees per year, 95% CI 0.038–0.068/0.025–0.054, whereas the association was minimal in men aged ≥50 years (right/left β = –0.006/0.001, 95% CI –0.026–0.014/-0.018–0.021). LDFA was positively associated with age among participants < 50 years, but showed no clear association thereafter. MPTA decreased with age in younger men and women, while remaining near zero or slightly positive in older groups. JLCA increased with age in participants ≥ 50 years, particularly in women.

Conclusion

Knee alignment demonstrated nonlinear associations with age and clear sex-related differences. These findings underscore the need to consider age- and sex-specific alignment characteristics in clinical evaluation and research on osteoarthritis risk.

目的：利用基于深度学习的自动测量的长腿x线片数据集，分析年龄和性别特异性与膝关节对齐的关联。方法：本回顾性横断面研究包括2010-2023年在韩国一家三级医院接受长腿x线摄影的有症状成人的8014张x线片（16028个膝关节）。利用深度学习模型自动提取胫骨股骨机械角（MTFA）、股骨外侧远端角（LDFA）、胫骨内侧近端角（MPTA）和关节线收敛角（JLCA）等对准参数。线性回归评估了按性别和年龄组（<50岁vs≥50岁）分层的年龄相关关联，调整了体重指数、kelgren - lawrence分级和临床适应症。结果调整后，不同性别和年龄组的膝关节对齐的年龄相关性存在差异。MTFA随着年龄的增长而增加，在≥50岁的女性中最为显著（右/左β = 0.053/0.040度/年，95% CI 0.038-0.068/0.025-0.054），而在≥50岁的男性中相关性最小（右/左β = -0.006/0.001, 95% CI -0.026-0.014/-0.018-0.021）。在< 50岁的参与者中，LDFA与年龄呈正相关，但此后无明显相关性。MPTA在年轻男性和女性中随着年龄的增长而下降，而在老年人群中保持接近零或略呈阳性。在≥50岁的参与者中，JLCA随年龄增长而增加，尤其是女性。结论膝关节线形与年龄呈非线性相关，性别差异明显。这些发现强调了在骨关节炎风险的临床评估和研究中考虑年龄和性别特异性排列特征的必要性。

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引用次数: 0

Tribute to Dr. Frank Beier (1965–2025) 向弗兰克·贝尔博士（1965-2025）致敬。

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.11.012

Cheryle A. Séguin, C. Thomas Appleton

引用次数: 0

Acknowledgement to Reviewers 2024-2025 对审稿人的致谢2024-2025

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 DOI: 10.1016/j.joca.2025.12.011

D. Hunter Editor in Chief, A.-M. Malfait Editor in Chief

引用次数: 0

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Osteoarthritis and Cartilage

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