Pub Date : 2024-10-16DOI: 10.1016/j.joca.2024.10.006
Tzu Han Feng,Chen Dong,Brian Shiian Chen,James Cheng Chung Wei
{"title":"Letter to the editor regarding \"Association between synovial tissue damage and pain in late-stage knee osteoarthritis: A cross-sectional study\".","authors":"Tzu Han Feng,Chen Dong,Brian Shiian Chen,James Cheng Chung Wei","doi":"10.1016/j.joca.2024.10.006","DOIUrl":"https://doi.org/10.1016/j.joca.2024.10.006","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"20 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OBJECTIVEInitiation of endoplasmic reticulum (ER) stress is pivotal to the advancement of osteoarthritis (OA). We aimed to explore the function of ER-resident selenoprotein M (SELM) in cartilage-forming chondrocytes, investigating how SELM participates in cartilage extracellular matrix (ECM) metabolism and ER stress modulation.METHODSArticular cartilage samples with knee OA undergoing total knee arthroplasty were categorized into OA-smooth and OA-damaged groups, with primary chondrocytes extracted from smooth areas. Destabilization of the medial meniscus was induced in male C57BL6/J mice, with sham operations on the left knee as controls. After 8 weeks, knee joint tissues were collected for analysis. Histology and immunohistochemistry examined cartilage damage. Molecular biology techniques investigated how SELM affects ECM metabolism and ER stress regulation. RNA sequencing revealed the pathway changes after SELM intervention. AlphaFold demonstrated how SELM interacts with other molecules. Cultured cartilage explants helped determine the effects of SELM supplementation.RESULTSSELM expression was reduced in the damaged cartilage. Increasing SELM levels positively impacted ECM equilibrium. Decreasing SELM expression activated genes linked to degenerative ailments and impaired the cellular response to misfolded proteins, initiating the PERK/P-EIF2A/ATF4 pathway and exacerbating GSH/GSSG imbalance via the ATF4/CHAC1 axis. SELM likely participated in protein folding and modification by leveraging its thioredoxin domains. In vitro SELM supplementation mitigated IL-1β effects on damaged cartilage explants and suppressed beneficial chondrocyte phenotypes.CONCLUSIONSOur results confirm the involvement of SELM in ER stress-induced cartilage damage as well as protein folding, pointing to new directions in molecular therapy for degenerative diseases.
{"title":"Protein Folding Dependence on Selenoprotein M Contributes to Steady Cartilage Extracellular Matrix Repressing Ferroptosis Via PERK/ATF4/CHAC1 Axis.","authors":"Yitong Zhao,Ying Zheng,Han Li,Yao Li,Ru Wang,Yongsong Cai,Haishi Zheng,Xinyu Huo,Jiajun Ren,Dongxian Guo,Rui Luo,Xinyao Wu,Jingyi Lu,Qingxin Song,Yan Zhang,Chenxing Ma,Lu Wang,Runyuan Wang,Jing Wang,Yingli He,Peng Xu,Jian Sun,Shemin Lu","doi":"10.1016/j.joca.2024.10.005","DOIUrl":"https://doi.org/10.1016/j.joca.2024.10.005","url":null,"abstract":"OBJECTIVEInitiation of endoplasmic reticulum (ER) stress is pivotal to the advancement of osteoarthritis (OA). We aimed to explore the function of ER-resident selenoprotein M (SELM) in cartilage-forming chondrocytes, investigating how SELM participates in cartilage extracellular matrix (ECM) metabolism and ER stress modulation.METHODSArticular cartilage samples with knee OA undergoing total knee arthroplasty were categorized into OA-smooth and OA-damaged groups, with primary chondrocytes extracted from smooth areas. Destabilization of the medial meniscus was induced in male C57BL6/J mice, with sham operations on the left knee as controls. After 8 weeks, knee joint tissues were collected for analysis. Histology and immunohistochemistry examined cartilage damage. Molecular biology techniques investigated how SELM affects ECM metabolism and ER stress regulation. RNA sequencing revealed the pathway changes after SELM intervention. AlphaFold demonstrated how SELM interacts with other molecules. Cultured cartilage explants helped determine the effects of SELM supplementation.RESULTSSELM expression was reduced in the damaged cartilage. Increasing SELM levels positively impacted ECM equilibrium. Decreasing SELM expression activated genes linked to degenerative ailments and impaired the cellular response to misfolded proteins, initiating the PERK/P-EIF2A/ATF4 pathway and exacerbating GSH/GSSG imbalance via the ATF4/CHAC1 axis. SELM likely participated in protein folding and modification by leveraging its thioredoxin domains. In vitro SELM supplementation mitigated IL-1β effects on damaged cartilage explants and suppressed beneficial chondrocyte phenotypes.CONCLUSIONSOur results confirm the involvement of SELM in ER stress-induced cartilage damage as well as protein folding, pointing to new directions in molecular therapy for degenerative diseases.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-05DOI: 10.1016/j.joca.2024.09.010
Ankita Gupta,Santosh K Mishra,B Duncan X Lascelles
Chronic musculoskeletal pain is highly prevalent and poses a significant personal, societal, and economic burden. Management of chronic musculoskeletal pain remains a challenge. Long-term use of common analgesic medications such as nonsteroidal anti-inflammatory drugs and opioids is associated with adverse events, and in the case of opioids, drug addiction. Additionally, many individuals do not experience sufficient pain relief with these therapeutic approaches. Thus, there is an urgent need to develop clinically efficacious and safe therapeutics for musculoskeletal pain. Recent advances in our understanding of musculoskeletal pain neurobiology have helped identify the role of neurotrophic factors, specifically, the GDNF Family of Ligands (GFL) and their associated signaling pathways. This review outlines our current understanding of the GFL signaling systems, discusses their role in inflammatory and chronic musculoskeletal pain and sensitivity, and comments on the analgesic therapeutic potential of targeting the GFL signaling system.
{"title":"Emerging Evidence of Artemin/GFRα3 Signaling in Musculoskeletal Pain.","authors":"Ankita Gupta,Santosh K Mishra,B Duncan X Lascelles","doi":"10.1016/j.joca.2024.09.010","DOIUrl":"https://doi.org/10.1016/j.joca.2024.09.010","url":null,"abstract":"Chronic musculoskeletal pain is highly prevalent and poses a significant personal, societal, and economic burden. Management of chronic musculoskeletal pain remains a challenge. Long-term use of common analgesic medications such as nonsteroidal anti-inflammatory drugs and opioids is associated with adverse events, and in the case of opioids, drug addiction. Additionally, many individuals do not experience sufficient pain relief with these therapeutic approaches. Thus, there is an urgent need to develop clinically efficacious and safe therapeutics for musculoskeletal pain. Recent advances in our understanding of musculoskeletal pain neurobiology have helped identify the role of neurotrophic factors, specifically, the GDNF Family of Ligands (GFL) and their associated signaling pathways. This review outlines our current understanding of the GFL signaling systems, discusses their role in inflammatory and chronic musculoskeletal pain and sensitivity, and comments on the analgesic therapeutic potential of targeting the GFL signaling system.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"68 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142385312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We aimed to systematically review and summarize the literature of the past year on osteoarthritis (OA) and biomechanics, to highlight gaps and challenges, and to present some promising approaches and developments.
Methods
A systematic literature search was conducted using Pubmed and the Web of Science Core Collection. We included original articles and systematic reviews on OA and biomechanics in human subjects published between April 2023 and April 2024.
Results
Of the 155 studies that met the inclusion criteria, 9 were systematic reviews and 146 were original (mostly cross-sectional) studies that included a total of 6488 patients and 1921 controls with a mean age of 57.5 and 44.7 years, respectively. Promising advances have been made in medical imaging of affected soft tissue structures, the relationship between soft tissue properties and biomechanical changes in OA, new technologies to facilitate easier assessment of ambulatory biomechanics, and personalized physics-based models that also include complex chemical and mechanobiological mechanisms, all of which are relevant to gaining mechanistic insights into the pathophysiology of OA.
Conclusions
There is still an unmet need for larger longitudinal data sets that combine clinical, radiological, and biomechanical outcomes to characterize the biomechanical fingerprint that underlies the trajectory of functional decline and biomechanical phenotypes of OA. In addition, criteria and guidelines for control groups, as well as methods and standards for model verification allowing for comparisons between studies are needed.
目的我们旨在系统回顾和总结过去一年有关 OA 和生物力学的文献，突出差距和挑战，并介绍一些有前景的方法和发展：使用 Pubmed 和 Web of Science Core Collection 进行了系统的文献检索。我们纳入了 2023 年 4 月至 2024 年 4 月间发表的关于人体 OA 和生物力学的原创文章和系统综述：结果：在符合纳入标准的 155 项研究中，9 项为系统综述，146 项为原创（大部分为横断面）研究，共纳入 6488 名患者和 1921 名对照者，平均年龄分别为 57.5 岁和 44.7 岁。受影响软组织结构的医学成像、OA 中软组织特性与生物力学变化之间的关系、便于评估非卧床生物力学的新技术以及基于物理学的个性化模型（其中还包括复杂的化学和机械生物学机制）等方面都取得了可喜的进展，所有这些都有助于从机理上深入了解 OA 的病理生理学：目前仍然需要结合临床、放射学和生物力学结果的更大规模的纵向数据集，以描述支撑 OA 功能衰退轨迹和生物力学表型的生物力学指纹。此外，还需要制定对照组的标准和指南，以及模型验证的方法和标准，以便在不同研究之间进行比较。
{"title":"Osteoarthritis year in review 2024: Biomechanics","authors":"Annegret Mündermann , Corina Nüesch , Hannah Ewald , Ilse Jonkers","doi":"10.1016/j.joca.2024.09.011","DOIUrl":"10.1016/j.joca.2024.09.011","url":null,"abstract":"<div><h3>Objective</h3><div>We aimed to systematically review and summarize the literature of the past year on osteoarthritis (OA) and biomechanics, to highlight gaps and challenges, and to present some promising approaches and developments.</div></div><div><h3>Methods</h3><div>A systematic literature search was conducted using Pubmed and the Web of Science Core Collection. We included original articles and systematic reviews on OA and biomechanics in human subjects published between April 2023 and April 2024.</div></div><div><h3>Results</h3><div>Of the 155 studies that met the inclusion criteria, 9 were systematic reviews and 146 were original (mostly cross-sectional) studies that included a total of 6488 patients and 1921 controls with a mean age of 57.5 and 44.7 years, respectively. Promising advances have been made in medical imaging of affected soft tissue structures, the relationship between soft tissue properties and biomechanical changes in OA, new technologies to facilitate easier assessment of ambulatory biomechanics, and personalized physics-based models that also include complex chemical and mechanobiological mechanisms, all of which are relevant to gaining mechanistic insights into the pathophysiology of OA.</div></div><div><h3>Conclusions</h3><div>There is still an unmet need for larger longitudinal data sets that combine clinical, radiological, and biomechanical outcomes to characterize the biomechanical fingerprint that underlies the trajectory of functional decline and biomechanical phenotypes of OA. In addition, criteria and guidelines for control groups, as well as methods and standards for model verification allowing for comparisons between studies are needed.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"32 12","pages":"Pages 1530-1541"},"PeriodicalIF":7.2,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-23DOI: 10.1016/j.joca.2024.09.005
Sung Yeon Kim, Carla R. Scanzello
{"title":"When ‘synovitis’ is not synovitis","authors":"Sung Yeon Kim, Carla R. Scanzello","doi":"10.1016/j.joca.2024.09.005","DOIUrl":"https://doi.org/10.1016/j.joca.2024.09.005","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"56 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142325676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-23DOI: 10.1016/j.joca.2024.09.006
Benjamin Tizian Baumann,Jule Nieuwstraten,Christian Konrads,Farshid Guilak,Marina Danalache
INTRODUCTIONThe intricate process of articular cartilage remodeling, pivotal for both physiological functions and osteoarthritis (OA) progression, is orchestrated through a balance of matrix synthesis and breakdown, which is mediated by matrix metalloproteinase enzymes (MMPs). At the heart of this remodeling lies the pericellular matrix (PCM), a specialized microenvironment encapsulating each chondrocyte and composed mainly of collagen type VI and perlecan. The aim of this study was to assess the impact of MMP-2, -3, and -7 on the structural integrity and biomechanical attributes of the PCM.METHODSHuman articular cartilage explants (N=10 patients) were incubated with activated MMP-2, -3, or -7, individually or in combination. Structural alterations in the PCM were evaluated by immunolabeling. The biomechanical properties of the PCM were measured using atomic force microscopy (AFM).RESULTSCollagen type VI structural integrity and fluorescence intensity uniformly decreased across all enzyme groups, while perlecan was selectively affected by MMP-3 and -7. AFM measurements demonstrated decreased PCM stiffness after incubation with individual MMPs, leading to an overall ~31 % reduction in elastic modulus for each enzyme. Combinations of enzymes induced comparable significant biomechanical alterations (~35 %), except for MMP-2+MMP-7.DISCUSSIONThis study highlights the significant influence of MMP-induced alterations in PCM composition on biomechanical properties, mirroring characteristics observed in early OA. Each MMP showed specificity in breaking down PCM, and an intriguing interplay, especially between MMP-2 and -7, indicated reduced efficacy in lowering PCM stiffness. Overall, MMP-2, -3, and -7 directly induce functional and structural PCM modifications.
{"title":"Cracking the Pericellular Matrix Code: Exploring How MMP-2, -3, and -7 Influence Matrix Breakdown and Biomechanical Properties.","authors":"Benjamin Tizian Baumann,Jule Nieuwstraten,Christian Konrads,Farshid Guilak,Marina Danalache","doi":"10.1016/j.joca.2024.09.006","DOIUrl":"https://doi.org/10.1016/j.joca.2024.09.006","url":null,"abstract":"INTRODUCTIONThe intricate process of articular cartilage remodeling, pivotal for both physiological functions and osteoarthritis (OA) progression, is orchestrated through a balance of matrix synthesis and breakdown, which is mediated by matrix metalloproteinase enzymes (MMPs). At the heart of this remodeling lies the pericellular matrix (PCM), a specialized microenvironment encapsulating each chondrocyte and composed mainly of collagen type VI and perlecan. The aim of this study was to assess the impact of MMP-2, -3, and -7 on the structural integrity and biomechanical attributes of the PCM.METHODSHuman articular cartilage explants (N=10 patients) were incubated with activated MMP-2, -3, or -7, individually or in combination. Structural alterations in the PCM were evaluated by immunolabeling. The biomechanical properties of the PCM were measured using atomic force microscopy (AFM).RESULTSCollagen type VI structural integrity and fluorescence intensity uniformly decreased across all enzyme groups, while perlecan was selectively affected by MMP-3 and -7. AFM measurements demonstrated decreased PCM stiffness after incubation with individual MMPs, leading to an overall ~31 % reduction in elastic modulus for each enzyme. Combinations of enzymes induced comparable significant biomechanical alterations (~35 %), except for MMP-2+MMP-7.DISCUSSIONThis study highlights the significant influence of MMP-induced alterations in PCM composition on biomechanical properties, mirroring characteristics observed in early OA. Each MMP showed specificity in breaking down PCM, and an intriguing interplay, especially between MMP-2 and -7, indicated reduced efficacy in lowering PCM stiffness. Overall, MMP-2, -3, and -7 directly induce functional and structural PCM modifications.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"24 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142325022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-16DOI: 10.1016/j.joca.2024.09.002
Sumit Bhutada, Anna Hoyle, Nicolas S. Piuzzi, Suneel S. Apte
Proteolytic cartilage extracellular matrix breakdown is a major mechanism of articular cartilage loss in osteoarthritis (OA) pathogenesis. We sought to determine the overlap of proteolytic peptides in matched knee OA cartilage and synovial fluid on a proteome-wide scale to increase the prospective biomarker repertoire and to attribute proteolytic cleavages to specific secreted proteases.
{"title":"Degradomics defines proteolysis information flow from human knee osteoarthritis cartilage to matched synovial fluid and the contributions of secreted proteases ADAMTS5, MMP13 and CMA1 to articular cartilage breakdown","authors":"Sumit Bhutada, Anna Hoyle, Nicolas S. Piuzzi, Suneel S. Apte","doi":"10.1016/j.joca.2024.09.002","DOIUrl":"https://doi.org/10.1016/j.joca.2024.09.002","url":null,"abstract":"Proteolytic cartilage extracellular matrix breakdown is a major mechanism of articular cartilage loss in osteoarthritis (OA) pathogenesis. We sought to determine the overlap of proteolytic peptides in matched knee OA cartilage and synovial fluid on a proteome-wide scale to increase the prospective biomarker repertoire and to attribute proteolytic cleavages to specific secreted proteases.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"12 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142246762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-12DOI: 10.1016/j.joca.2024.09.003
Niko Sillanpää, Marika Iivanainen, Aleksandra Turkiewicz, Raine Sihvonen, Mika Paavola, Simo Taimela, Teppo L.N. Järvinen, Martin Englund
To assess the 5-year effects of arthroscopic partial meniscectomy (APM) vs. placebo surgery on the development of the structural changes of the knee by magnetic resonance imaging (MRI).
{"title":"Effect of arthroscopic partial meniscectomy on structural degeneration of the knee – A 5-year MRI-based follow-up of the placebo-surgery controlled FIDELITY (Finnish Degenerative Meniscus Lesion Study) trial","authors":"Niko Sillanpää, Marika Iivanainen, Aleksandra Turkiewicz, Raine Sihvonen, Mika Paavola, Simo Taimela, Teppo L.N. Järvinen, Martin Englund","doi":"10.1016/j.joca.2024.09.003","DOIUrl":"https://doi.org/10.1016/j.joca.2024.09.003","url":null,"abstract":"To assess the 5-year effects of arthroscopic partial meniscectomy (APM) vs. placebo surgery on the development of the structural changes of the knee by magnetic resonance imaging (MRI).","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"13 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142246763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-12DOI: 10.1016/j.joca.2024.09.004
Aleksandra Turkiewicz, Clara Hellberg, Andrea Dell’Isola, Martin Englund
Antihistamines have been reported to be linked with less pain in osteoarthritis. We aimed to estimate associations between antihistamine use and three outcomes: prevalent osteoarthritis, current joint pain, and developing osteoarthritis.
{"title":"Antihistamine use and osteoarthritis or joint pain","authors":"Aleksandra Turkiewicz, Clara Hellberg, Andrea Dell’Isola, Martin Englund","doi":"10.1016/j.joca.2024.09.004","DOIUrl":"https://doi.org/10.1016/j.joca.2024.09.004","url":null,"abstract":"Antihistamines have been reported to be linked with less pain in osteoarthritis. We aimed to estimate associations between antihistamine use and three outcomes: prevalent osteoarthritis, current joint pain, and developing osteoarthritis.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"12 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142246814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-12DOI: 10.1016/j.joca.2024.09.001
Rupsa Bhattacharjee , Eric Hammond , Ngarmsrikam Chotigar , Zehra Akkaya , Fei Jiang , Emma Bahroos , Misung Han , Spencer Behr , Matthew D. Bucknor , Richard B. Souza , Valentina Pedoia , Sharmila Majumdar
Objective
Loading is invariably an important factor of consideration for understanding the causality flow and parallel existence of articular cartilage and subchondral bone changes. The goal of this study was to investigate the patterns of subregional 18NaF-SUV vs. T1p-T2 associations and vertical ground reaction force loading rates; in isolated patellofemoral-joint-osteoarthritis (PFJ-OA) patients.
Method
Thirty-five isolated PFJ-OA patients, with no tibiofemoral involvement, underwent simultaneous scans in a 3.0T whole-body hybrid positron emission tomography–magnetic resonance imaging scanner. MRI Whole-Organ Magnetic Resonance Imaging Scoring assessments were performed to identify/confirm isolated PFJ-OA knees from bilateral scans. T1p-T2 relaxation and SUV values were automatically computed for both trochlear and patellar cartilage and subchondral bone subregions (deep, superficial, lateral, and medial). Maximum vertical impact loading rates (Loading-RateNorm) were calculated from walking trials. Relationships were explored between SUV uptake, T1p-T2 values, and Loading-RateNorm via linear mixed-effects modeling.
Results
Significant and complex association patterns were noted between medial and lateral bone 18NaF-SUV uptakes vs. medial and lateral cartilage sub-regional T1p and T2. SUVMean and SUVMax were positively associated with deep cartilage subregional T1pand T2 values; and negatively associated with superficial cartilage subregional T1p-T2 values in both medial and lateral regions. Both medial and lateral bone 18NaF-SUVMean and SUVMax uptakes remained positively associated with the individual gait characteristics, i.e., peak vertical impact loading rates (Loading-RateNorm).
Conclusion
Evidence of simultaneous, complementary, cross-sectional associations between T1p-T2 values and peak vertical loading rates with 18NaF-SUV, have been rare in the isolated PFJ-OA cohort. The clinical implications of such novel associations remain of utmost importance from a gait retraining perspective.
{"title":"The relationships between patellofemoral bone remodeling, cartilage composition, and vertical loading rate: PET/MRI in isolated patellofemoral osteoarthritis","authors":"Rupsa Bhattacharjee , Eric Hammond , Ngarmsrikam Chotigar , Zehra Akkaya , Fei Jiang , Emma Bahroos , Misung Han , Spencer Behr , Matthew D. Bucknor , Richard B. Souza , Valentina Pedoia , Sharmila Majumdar","doi":"10.1016/j.joca.2024.09.001","DOIUrl":"10.1016/j.joca.2024.09.001","url":null,"abstract":"<div><h3>Objective</h3><div>Loading is invariably an important factor of consideration for understanding the causality flow and parallel existence of articular cartilage and subchondral bone changes. The goal of this study was to investigate the patterns of subregional <sup>18</sup>NaF-SUV vs. T<sub>1<em>p</em></sub>-T<sub>2</sub> associations and vertical ground reaction force loading rates; in isolated patellofemoral-joint-osteoarthritis (PFJ-OA) patients.</div></div><div><h3>Method</h3><div>Thirty-five isolated PFJ-OA patients, with no tibiofemoral involvement, underwent simultaneous scans in a 3.0T whole-body hybrid positron emission tomography–magnetic resonance imaging scanner. MRI Whole-Organ Magnetic Resonance Imaging Scoring assessments were performed to identify/confirm isolated PFJ-OA knees from bilateral scans. T<sub>1<em>p</em></sub>-T<sub>2</sub> relaxation and SUV values were automatically computed for both trochlear and patellar cartilage and subchondral bone subregions (deep, superficial, lateral, and medial). Maximum vertical impact loading rates (Loading-Rate<sub>Norm</sub>) were calculated from walking trials. Relationships were explored between SUV uptake, T<sub>1<em>p</em></sub>-T<sub>2</sub> values, and Loading-Rate<sub>Norm</sub> via linear mixed-effects modeling.</div></div><div><h3>Results</h3><div>Significant and complex association patterns were noted between medial and lateral bone <sup>18</sup>NaF-SUV uptakes vs. medial and lateral cartilage sub-regional T<sub>1<em>p</em></sub> and T<sub>2</sub>. SUV<sub>Mean</sub> and SUV<sub>Max</sub> were positively associated with deep cartilage subregional T<sub>1<em>p</em></sub> <em>and</em> T<sub>2</sub> values; and negatively associated with superficial cartilage subregional T<sub>1<em>p</em></sub><em>-</em>T<sub>2</sub> values in both medial and lateral regions. Both medial and lateral bone <sup>18</sup>NaF-SUV<sub>Mean</sub> and SUV<sub>Max</sub> uptakes remained positively associated with the individual gait characteristics, i.e., peak vertical impact loading rates (Loading-Rate<sub>Norm</sub>).</div></div><div><h3>Conclusion</h3><div>Evidence of simultaneous, complementary, cross-sectional associations between T<sub>1<em>p</em></sub><em>-</em>T<sub>2</sub> values and peak vertical loading rates with <sup>18</sup>NaF-SUV, have been rare in the isolated PFJ-OA cohort. The clinical implications of such novel associations remain of utmost importance from a gait retraining perspective.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"32 12","pages":"Pages 1591-1600"},"PeriodicalIF":7.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142246856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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