Osteoarthritis and Cartilage最新文献

英文中文

Response to the Letter to the Editor: Effects of pre- and postsurgery physical activity interventions on physical activity and sedentary behavior levels following knee and hip arthroplasty: A systematic review and meta-analysis of randomized controlled trials 给编辑的回复：术前和术后体育活动干预对膝关节和髋关节置换术后体育活动和久坐行为水平的影响：随机对照试验的系统回顾和荟萃分析

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 Epub Date: 2025-10-30 DOI: 10.1016/j.joca.2025.10.013

Noah d’Unienville, Bethany Gower, Ben Singh, Kimberley Szeto, Heather Badger, Matilda Krywanio, Carol Maher , Dominic Thewlis

引用次数: 0

Partitioning knee osteoarthritis genetic variants based on BMI association to improve polygenic risk prediction 基于BMI关联划分膝骨关节炎遗传变异以改善多基因风险预测。

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 Epub Date: 2025-09-30 DOI: 10.1016/j.joca.2025.09.018

Bahar Sedaghati–Khayat , Katerina Trajanoska , Cindy G. Boer , Fernando Rivadeneira , André G. Uitterlinden , Joyce B.J. van Meurs , Jeroen G.J. van Rooij

Introduction

Polygenic risk scores (PRSs) show promise for improving knee osteoarthritis (KOA) risk prediction. However, many KOA-associated variants are also linked to body mass index (BMI)—a major KOA risk factor—complicating the combined use of PRS and BMI in predictive models. This study aimed to disentangle BMI-mediated from BMI-independent genetic contributions to KOA by partitioning the KOA-PRS.

Method

Using data from 345,080 white European participants in the UK Biobank, we refined a KOA-PRS based on 146 genome-wide significant variants identified by the GO consortium. KOA variants were partitioned into BMI-associated (KOA-BMI PRS), and BMI-independent (KOA-nonBMI PRS) groups based on linkage disequilibrium with BMI-associated variants from the GIANT consortium. We assessed associations of each PRS with prevalent and incident KOA (with and without BMI adjustment), with BMI in cases and controls, and with KOA across BMI strata.

Results

Of the 146 KOA-associated variants, 73 were classified as BMI-associated. The KOA-BMI PRS was associated with incident KOA (OR per SD:1.23;95%CI:1.20–1.26), attenuated after BMI adjustment (1.18;1.15–1.21). In contrast, the KOA-nonBMI PRS remained robust to BMI adjustment (1.24 before vs.1.23 after-adjustment). KOA-nonBMI PRS was negatively associated with BMI in KOA cases (β=–0.09;95%CI:–0.17to–0.01), but not in controls. Stratified analyses showed its effect on KOA diminished in higher BMI strata, while KOA-BMI PRS effects remained stable.

Conclusion

Half of KOA-associated variants overlap with BMI loci. Partitioning the KOA-PRS improves interpretation by distinguishing BMI-driven from independent genetic effects—enhancing prediction and informing tailored prevention. Validation in diverse populations is warranted.

多基因风险评分（PRSs）有望改善膝骨关节炎（KOA）的风险预测。然而，许多与KOA相关的变异也与身体质量指数（BMI）有关，这是一个主要的KOA风险因素，使PRS和BMI在预测模型中的联合使用复杂化。本研究旨在通过划分KOA- prs来解开bmi介导的与bmi独立的遗传对KOA的贡献。方法使用来自英国生物银行345,080名欧洲白人参与者的数据，我们基于GO联盟鉴定的146个全基因组显著变异完善了KOA-PRS。根据与GIANT联盟中bmi相关变异的连锁不平衡，将KOA变异分为bmi相关（KOA- bmi PRS）和bmi独立（KOA-非bmi PRS）两组。我们评估了每一种PRS与流行的和偶发的KOA（有和没有BMI调整）、病例和对照组的BMI以及不同BMI层的KOA的关联。结果146例koa相关变异中，73例归为bmi相关。KOA-BMI PRS与KOA事件相关（OR / SD:1.23;95%CI:1.20 ~ 1.26）， BMI调整后减弱（1.18;1.15 ~ 1.21）。相比之下，koa -非BMI PRS对BMI调整保持稳健（调整前为1.24，调整后为1.23）。在KOA病例中，KOA-非BMI PRS与BMI呈负相关（β=-0.09;95%CI:-0.17 -0.01），但在对照组中没有。分层分析表明，高BMI地层对KOA的影响减弱，而KOA-BMI PRS效应保持稳定。结论半数koa相关变异与BMI位点重叠。通过区分bmi驱动和独立的遗传效应，划分KOA-PRS改善了解释，增强了预测，并为量身定制的预防提供了信息。有必要在不同人群中进行验证。

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引用次数: 0

Osteoarthritis year in review 2025: Rehabilitation and outcomes including sex and gender reporting 骨关节炎2025年回顾：康复和结果包括性别和性别报告

IF 9 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2026-01-01 Epub Date: 2025-10-30 DOI: 10.1016/j.joca.2025.10.008

Andrea M. Bruder , Matthew G. King , Chantal M. Hulshof , Harvi F. Hart , Brooke E. Patterson , Britt Elin Øiestad , Bjørnar Berg , Joanne L. Kemp , Adam G. Culvenor

This year in review (1) narratively synthesises the effect of, or patient experience with, non-pharmacological or non-surgical rehabilitation treatments for osteoarthritis at any joint; and (2) describes how sex and/or gender are defined, reported, and analysed. We searched three databases (Medline, Embase, CINAHL) for studies that met predefined criteria and selected those of perceived moderate-to-high quality and importance published between 12th March 2024 and 1st March 2025. Studies were grouped according to predominant treatment topic areas (e.g. core [exercise, diet]; adjunct [electrotherapy, manual therapy]; multimodal [different rehabilitation treatments]). Two authors independently screened records. One author extracted data, and another checked 10% of the accuracy. Full-text screening identified 158 eligible studies, reduced to 39 for synthesis. We identified eight themes: i) Exercise is effective for knee osteoarthritis and comorbidities, but has varied effects for hip osteoarthritis; ii) Diet plus exercise is effective for weight loss, but may not reduce pain; iii) Digital rehabilitation is a viable alternative to in-person care; iv) No added benefit of mind/behavioural treatments; v) Effects of electrotherapy modalities on pain were inconsistent and region-specific; vi) Orthoses may relieve pain, but should be individualised to patient preferences; vii) Acupuncture and blood flow restriction treatment show effectiveness in single clinical trials; viii) Treatment packages for osteoarthritis have varied benefits. Sex and gender were reported in 23 and 11 studies, respectively. For gender, most studies used female/male/woman/man interchangeably. No study defined sex or gender, 5% reported results disaggregated by sex or gender, no study justified why results were not, and 5% summarised key sex or gender findings.

今年的综述(1)叙述性地综合了任何关节骨关节炎的非药物或非手术康复治疗的效果或患者经验；(2)描述如何定义、报告和分析性和/或性别。我们检索了三个数据库（Medline, Embase， CINAHL）以寻找符合预定义标准的研究，并选择了2024年3月12日至2025年3月1日之间发表的被认为是中高质量和重要性的研究。研究根据主要的治疗主题领域进行分组（例如核心[运动，饮食]；辅助[电疗，手工治疗]；多模式[不同的康复治疗]）。两位作者独立筛选了记录。一位作者提取数据，另一位检查10%的准确性。全文筛选确定了158项符合条件的研究，合成研究减少到39项。我们确定了八个主题：1)运动对膝关节骨性关节炎和合并症有效，但对髋关节骨性关节炎有不同的影响；ii)饮食加运动对减肥有效，但可能不能减轻疼痛；iii)数字康复是面对面护理的可行替代方案；iv)心理/行为治疗没有额外的好处；v)电疗方式对疼痛的影响不一致且具有区域特异性；矫形器可以缓解疼痛，但应根据患者的喜好进行个体化治疗；单次临床试验表明针灸和限血治疗有效；骨关节炎的治疗方案有不同的益处。性别和社会性别分别在23项和11项研究中被报道。对于性别，大多数研究交替使用女性/男性/女性/男性。没有研究定义性别或性别，5%的研究报告了按性别或性别分类的结果，没有研究证明为什么结果不是这样，5%的研究总结了关键的性别或性别发现。

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引用次数: 0

Osteocyte-Intrinsic MMP13 Exacerbates Injury-Induced Temporomandibular Joint Osteoarthritis 骨细胞-内源性MMP13加剧损伤性颞下颌关节骨关节炎

IF 7 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-12-27 DOI: 10.1016/j.joca.2025.12.019

Cristal S. Yee, Marianne Demirdji, Karsyn N. Bailey, Alena Larios, Christoforos Meliadis, Clarissa Aguirre Luna, Harrison B. Taylor, Peggi M Angel, Sunil Kapila, Tamara Alliston

引用次数: 0

Why is there no treatment for osteoarthritis - Opportunity for AI based big data analytics to advance the field 为什么没有治疗骨关节炎的方法——基于人工智能的大数据分析推动该领域发展的机会

IF 7 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-12-26 DOI: 10.1016/j.joca.2025.12.021

F Saxer, G Jansen, S M A Bierma-Zeinstra, B Holzhauer, D Demanse, J Melnick, D Vukadinovic Greetham, T Rall, P Mesenbrink, M Schieker

引用次数: 0

Using both disease and illness as outcomes is critical in OA prevention research 在OA预防研究中，将疾病和疾病作为结果是至关重要的

IF 7 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-12-26 DOI: 10.1016/j.joca.2025.12.010

Ewa M Roos

引用次数: 0

Engineered Cationic Interleukin-1 Receptor Antagonist Outperforms Anakinra at Joint Retention and Preventing IL-1-induced Cartilage Inflammation 工程阳离子白介素-1受体拮抗剂在关节潴留和预防白介素-1诱导的软骨炎症方面优于阿那白素

IF 7 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-12-24 DOI: 10.1016/j.joca.2025.12.018

Timothy L. Boyer, Bill Hakim, Luke Childress, Helna M. Baby, Ryan M. Porter, Ambika G. Bajpayee

引用次数: 0

Why most responder analyses are misleading 为什么大多数回应分析都具有误导性

IF 7 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-12-21 DOI: 10.1016/j.joca.2025.12.020

Aleksandra Turkiewicz, Marius Henriksen, Jos Runhaar, Martin Englund

引用次数: 0

Reframing Early-stage Symptomatic Knee Osteoarthritis (EsSKOA): A Strategic Lens for Trial Design 重构早期症状性膝骨关节炎（EsSKOA）：试验设计的一个策略镜头

IF 7 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-12-20 DOI: 10.1016/j.joca.2025.12.016

Armaghan Mahmoudian, Lauren K King, Jean W Liew, Qiuke Wang, Francis Berenbaum, Siddharth Das, Changhai Ding, Carolyn A Emery, Stephanie R Filbay, Marc C Hochberg, Muneaki Ishijima, Margreet Kloppenburg, Nancy E Lane, Elena Losina, Ali Mobasheri, C Thomas Appleton, Martin Englund, L Stefan Lohmander, Jos Runhaar, Aleksandra Turkiewicz, Gillian A Hawker, Tuhina Neogi, Ida K Haugen

引用次数: 0

Metformin and incident osteoarthritis: Causal insights from a co-twin control study 二甲双胍和骨关节炎：来自双胎对照研究的因果见解

IF 7 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage

Pub Date : 2025-12-19 DOI: 10.1016/j.joca.2025.12.014

Karin Magnusson, Aleksandra Turkiewicz, Andrea Dell’Isola, Ali Kiadaliri, Martin Englund

引用次数: 0

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