Osteoarthritis and Cartilage最新文献

{"title":"Disparities in incident osteoarthritis between sexual minority and heterosexual adults: Findings from a large cohort study","authors":"Tingting Sha ,&nbsp;Yilun Wang ,&nbsp;Yuqing Zhang ,&nbsp;Jian Zhang ,&nbsp;Cong Lu ,&nbsp;Jie Wei ,&nbsp;Guanghua Lei ,&nbsp;Chao Zeng","doi":"10.1016/j.joca.2025.10.001","DOIUrl":"10.1016/j.joca.2025.10.001","url":null,"abstract":"<div><h3>Objective</h3><div>Sexual minorities, including lesbian, gay, and bisexual individuals, experience persistent health disparities due to chronic exposure to minority stressors; however, its relation to osteoarthritis (OA) risk remains unexplored. This study aims to investigate the association between sexual orientation and OA risk and evaluate the mediating effect of health behaviors and psychosocial factors in related disparities.</div></div><div><h3>Methods</h3><div>We conducted a prospective cohort study of 346,320 UK Biobank participants without OA at baseline (2006–2010), followed through December 2021. Coarsened exact matching was applied to balance age, birth cohort, and ethnicity. Sex-stratified Cox models (using age as the time scale) were used to estimate hazard ratios (HRs) for OA risk. Mediation analyses examined the roles of modifiable factors, including body mass index (BMI), socioeconomic status, lifestyle behaviors, and mental health.</div></div><div><h3>Results</h3><div>Over a median follow-up of 11.3 years, 40,728 participants developed OA. Both bisexual and lesbian women had a higher OA risk than heterosexual women (adjusted HR: 1.17, 95%CI [confidence interval]: 1.07–1.28 and HR: 1.36, 95%CI: 1.10–1.68, respectively). Mediation analysis identified BMI, Townsend index, smoking, and depression as potential mediators, with mediation proportions ranging from 12.1% to 34.2%. In men, gay individuals had lower OA risk (HR: 0.72, 95%CI: 0.60–0.85), with BMI and education explaining 17.5–18.4% of the reduction; no significant difference was observed for bisexual men.</div></div><div><h3>Conclusion</h3><div>Sexual orientation is associated with OA risk, with bisexual and lesbian women showing higher risk and gay men lower risk than heterosexuals. These disparities are partially explained by BMI, smoking, depression, and socioeconomic status.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 2","pages":"Pages 271-278"},"PeriodicalIF":9.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145277328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of peptidergic innervation of the subchondral bone in a murine model of MIA-induced osteoarthritis","authors":"Jason Ivanusic ,&nbsp;Wendy Imlach ,&nbsp;Jenny Thai ,&nbsp;Jacob Bos ,&nbsp;Jackson Hart ,&nbsp;John-Paul Fuller-Jackson","doi":"10.1016/j.joca.2025.09.016","DOIUrl":"10.1016/j.joca.2025.09.016","url":null,"abstract":"<div><h3>Objective</h3><div>In the present study, we aimed to determine how osteoarthritis (OA) affects the morphology and distribution of nociceptive nerve endings in the subchondral bone of animals with mono-iodoacetate (MIA)-induced OA.</div></div><div><h3>Design</h3><div>We used a modified version of the immunolabeling-enabled imaging of solvent-cleared organs (iDISCO/iDISCO+) protocol to visualize peptidergic (CGRP+) nerve terminal labeling in 3D volumes of subchondral bone around the murine knee joint. Total nerve length, number of branch points, and number of endings were derived from manual filament tracing, and were used to quantify changes in animals with MIA-induced OA vs control animals. Von Frey testing was used to assay pain behavior.</div></div><div><h3>Results</h3><div>In control animals, peptidergic nerves were distributed extensively throughout the condyles of both the tibia and femur. There was a decrease in innervation of the subchondral bone in animals injected with MIA, relative to those injected with saline (n=4/group, Mann-Whitney U-test, P&lt;0.05), that was more obvious in the tibia (filament length μm, saline mean 47,556 [min. 21,442, max. 86,615], MIA mean 4037 [min. 663, max. 10,813]) than the femur (filament length μm, saline mean 37,321 [min. 31,630, max.44,530], MIA mean 18,665 [min. 8670, max. 31,557]). The extent of pain behavior was associated with decreased innervation in the tibia, but not the femur.</div></div><div><h3>Conclusions</h3><div>Our findings offer unprecedented 3D insight into the full extent of innervation of subchondral bone around the murine knee joint and indicate that there is a loss of peptidergic innervation in the subchondral bone around knee joints of animals with MIA-induced OA.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 12","pages":"Pages 1419-1429"},"PeriodicalIF":9.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A single intra-articular injection of JTA-004, a combination of human plasma, hyaluronic acid, and clonidine, versus placebo in symptomatic knee osteoarthritis: A Phase 3 trial","authors":"Asger Reinstrup Bihlet ,&nbsp;Yves Henrotin ,&nbsp;Edith Ming Chu Lau ,&nbsp;Peter Alexandersen ,&nbsp;Olivier Godeaux ,&nbsp;Helene Rovsing ,&nbsp;François Rieger ,&nbsp;Carole Nicco","doi":"10.1016/j.joca.2025.09.015","DOIUrl":"10.1016/j.joca.2025.09.015","url":null,"abstract":"<div><h3>Objectives</h3><div>Intra-articular treatments for osteoarthritis (OA) are limited by their efficacy, safety, or duration of response. JTA-004 is a potential novel treatment for OA for intra-articular (IA) injection, combining hyaluronic acid (HA) and clonidine with human plasma to enhance the effects of HA. The objectives of the trial were to evaluate the efficacy and safety of JTA-004 in participants with symptomatic knee OA, where the primary objective was evaluating the efficacy of JTA-004 in terms of WOMAC pain, compared to placebo.</div></div><div><h3>Design</h3><div>The trial was a multicenter, Phase 3, randomized, double-blind, placebo- and active-controlled clinical trial, evaluating the efficacy and safety of a single IA injection of JTA-004, compared to saline (primary hypothesis) and an HA-comparator (Synvisc-One®) (secondary hypothesis) in knee OA with a Kellgren-Lawrence grade of 2 or 3. For the secondary hypothesis, non-inferiority of JTA-004 to active comparator by comparing the 2 treatment groups on the mean differences in WOMAC pain with a non-inferiority margin of Δ = 10 mm. Primary efficacy endpoint was the change from baseline in WOMAC pain to Month 3. The main secondary efficacy endpoints included changes from baseline in WOMAC function and stiffness at Months 3 and 6, OMERACT-OARSI responder rates, global assessments, and use of rescue medication. Safety assessments were based on adverse events (AE) reporting, and post-injection vital signs.</div></div><div><h3>Results</h3><div>A total of 746 participants were randomized, of which 687 (92.1%) completed the trial. The results indicated no significant differences in the primary endpoint between JTA-004 and placebo (LSmean difference: −1.50 mm, 95%CI 5.12; 2.12, p= 0.42) or Synvisc-One® (LSmean difference: 2.40, 95% CI: −1.22; 6.02, p=0.20) nor in either of the efficacy outcomes of the main study population. The safety and tolerability of JTA-004 was good, and there were no differences in the frequency of any of the reported AEs or trial discontinuations between the study groups.</div></div><div><h3>Conclusions</h3><div>A single IA injection of JTA-004 was not superior to a saline solution (LSmean difference: −1.50 mm, 95%CI 5.12; 2.12, p= 0.42) or Synvisc-One® (LSmean difference: 2.40, 95% CI: −1.22; 6.02, p=0.20) for the treatment of OA symptoms in the overall study population.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 2","pages":"Pages 279-289"},"PeriodicalIF":9.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Definitions and reporting of usual care in randomized trials for the treatment of knee osteoarthritis: A scoping review","authors":"Victoria D’Alessandro ,&nbsp;Dimitra V. Pouliopoulou ,&nbsp;Marjan Saeedi ,&nbsp;Joy C. MacDermid ,&nbsp;Nicole Billias ,&nbsp;Aidan Loh ,&nbsp;Jessica J. Wong ,&nbsp;Trevor Birmingham ,&nbsp;Lauren K. King ,&nbsp;Tiago V. Pereira ,&nbsp;Bruno R. da Costa ,&nbsp;Pavlos Bobos","doi":"10.1016/j.joca.2025.09.013","DOIUrl":"10.1016/j.joca.2025.09.013","url":null,"abstract":"<div><h3>Objective</h3><div>“Usual care” is a common comparator in randomized trials (RCTs) evaluating interventions for knee osteoarthritis (OA), but it lacks a standardized definition. This scoping review aimed to systematically map how usual care has been defined and reported in knee OA RCTs, with attention to the terminology, components, and adherence to reporting standards.</div></div><div><h3>Methods</h3><div>We searched MEDLINE, EMBASE, CENTRAL, CINAHL, and the ClinicalTrials.gov registry from inception to May 2025 for trials involving adults with knee OA that compared a non-surgical intervention to usual care (or similar terms). Paired reviewers independently screened citations and extracted study characteristics, terminology used to describe and components of usual care, care setting, OA severity and diagnosis, intervention type, and references to external guidelines. We summarized findings and assessed reporting quality using the Template for Intervention Description and Replication (TIDieR) and Consensus on Exercise Reporting Template (CERT) checklists, where applicable.</div></div><div><h3>Results</h3><div>Of 11804 citations screened, we identified 154 RCTs across 33 countries. “Usual care” was the most frequently used descriptor term (53.9%), with definitions that varied considerably. While 68.2% of trials provided detailed descriptions, nearly one-third offered only vague or minimal information. Only 22.7% referenced external guidelines. Usual care content ranged from minimal care to complex multimodal packages, with substantial variation by intervention type. Reporting quality was suboptimal: trials addressed, on average, just over half of TIDieR and approximately two thirds of CERT checklist items. Usual care often lacked transparency, standardization, and reference to best practice recommendations.</div></div><div><h3>Conclusion</h3><div>One in three knee OA trials using usual care as a comparator did not provide a clear, detailed definition of “usual care.” Variability in usual care definitions and reporting compromise trial validity, limit evidence synthesis, and hinder clinical translation. There is an urgent need for standardization of detailed reporting of usual care interventions in knee OA trials.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 12","pages":"Pages 1485-1501"},"PeriodicalIF":9.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization rates of hip arthroplasty in OECD countries revised","authors":"Jonas Backes ,&nbsp;Christof Pabinger ,&nbsp;Harald Lothaller ,&nbsp;Alexander Geissler","doi":"10.1016/j.joca.2025.09.012","DOIUrl":"10.1016/j.joca.2025.09.012","url":null,"abstract":"<div><h3>Objective</h3><div>In 2014, we reported rising hip arthroplasty utilization across Organization for Economic Co-operation and Development (OECD) countries, particularly among younger patients. Since then, healthcare systems have evolved, demographic shifts are continued, and procedures were impacted by the COVID-19 pandemic. This study aims to reassess these trends through 2022.</div></div><div><h3>Methods</h3><div>We analyzed hip arthroplasty data from the OECD Health Statistics, U.S. Nationwide Inpatient Sample, and World Bank for 27 countries (2005–2022). We compared relative (compound annual growth rates (CAGR)) and absolute (i.e., mean annual differences (MAD)) procedure numbers, stratified by age (≤64 vs. ≥65), and examined associations with GDP, health expenditure, and life expectancy. Sensitivity analyses were performed to account for uncertainty in U.S. data.</div></div><div><h3>Results</h3><div>Between 2011 and 2022, hip arthroplasty utilization grew more slowly than 2005–2011 (CAGR: 1.00% vs. 2.03%; MAD: 1.78 vs. 2.03). Growth from 2011 to 2022 was concentrated among patients aged ≤64 (CAGR 3.08%; MAD: 3.11), while utilization declined among those ≥65 (CAGR: −2.27%; MAD: −12.46). Country-level variation narrowed, with the highest-to-lowest ratio falling from 6.65 (2005) to 2.96 (2022). Despite a sharp drop in 2020 due to COVID-19, most countries recovered by 2022. Sensitivity analyses confirmed the robustness of observed OECD trends. BRIC nations showed faster growth, but data limitations hindered comparisons.</div></div><div><h3>Conclusion</h3><div>Hip arthroplasty utilization continues to increase among younger patients but has declined in older ones. Continued demographic pressure and recovery from COVID-19 disruptions are expected to drive further increases in procedure volume.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 12","pages":"Pages 1475-1484"},"PeriodicalIF":9.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcript profiling reveals IL-1β and TGF-β1 regulation of chemokine expression in fibroblast-like synoviocytes.","authors":"Lei Cai,Robert H Brophy,Eric D Tycksen,Muhammad Farooq Rai","doi":"10.1016/j.joca.2025.09.011","DOIUrl":"https://doi.org/10.1016/j.joca.2025.09.011","url":null,"abstract":"OBJECTIVEFibroblast-like synoviocytes (FLS) are crucial in maintaining joint homeostasis under normal physiological conditions. However, under inflammatory settings, they release factors contributing to tissue damage and osteoarthritis (OA). This study evaluates FLS as a disease-relevant model by profiling transcriptome-wide responses following IL-1β exposure and assessing whether TGF-β1 can antagonize these responses.DESIGNPrimary FLS from synovial explants of patients undergoing anterior cruciate ligament reconstruction were expanded and exposed to IL-1β (10-ng/mL) for 24h to simulate an inflammatory microenvironment characteristic of OA. Transcriptomic changes were profiled using the Illumina NovaSeq-6000 platform and validated through Fluidigm multiplex digital PCR. To assess the immunomodulatory effects of TGF-β1, FLS were treated with TGF-β1 (10-ng/mL) for 48h following IL-1β exposure, and chemokine gene expression was analyzed by digital PCR.RESULTSIL-1β-treated FLS exhibited marked upregulation of several chemokines (e.g., CCL20, CXCL8) and other arthritis-related genes (CSF2, MMP12, IL1B, LIPM), while downregulation of KRT14, KRT19, KRT18, and other anabolic and cytoskeletal genes. Highly expressed genes were enriched in NFκB, cytokine/chemokine, TNF signaling, and necroptosis/ferroptosis pathways. Notably, TGF-β1 significantly reduced IL-1β-induced chemokines. Mechanistically, this suppression correlated with about a 50% reduction in the expression of NFκB and C/EBPβ transcription factors, suggesting that TGF-β1 mediates anti-chemokine effects in part through transcriptional repression of NFκB and C/EBPβ.CONCLUSIONSIL-1β induces exuberant inflammatory responses in FLS, akin to chondrocytes, highlighting that FLS can effectively model inflammatory OA. Importantly, TGF-β1 emerges as a potent modulator capable of suppressing these responses, positioning it as a potential therapeutic candidate for restoring joint homeostasis.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"17 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational translation of mouse models of osteoarthritis predicts human disease.","authors":"Maya R Frost, Brendan K Ball, Meghana Pendyala, Stephen R Douglas, Douglas K Brubaker, Deva D Chan","doi":"10.1016/j.joca.2025.09.010","DOIUrl":"10.1016/j.joca.2025.09.010","url":null,"abstract":"<p><strong>Objective: </strong>Translation of biological insights from preclinical studies to human disease is a pressing challenge in biomedical research, including in osteoarthritis. Translatable Components Regression (TransComp-R) is a computational framework previously used to identify biological pathways predictive of human disease conditions. We aimed to evaluate the translatability of two common murine models of post-traumatic osteoarthritis - surgical destabilization of the medial meniscus (DMM) and noninvasive anterior cruciate ligament rupture (ACLR) - to transcriptomics cartilage data from human osteoarthritis studies.</p><p><strong>Method: </strong>Publicly available transcriptomics cartilage data from mouse models and human osteoarthritis were analyzed. TransComp-R was used to project human osteoarthritis data into either DMM or ACLR mouse model principal component analysis space. The principal components (PCs) were regressed against human osteoarthritis using increasing complexity of linear regression models incorporating human covariates of sex and age. Biological pathways of the mouse PCs that significantly stratified human osteoarthritis and control groups were then interpreted using Gene Set Enrichment Analysis.</p><p><strong>Results: </strong>Using TransComp-R, we identified different enriched biological pathways across DMM and ACLR models. Both murine models predicted at least one human study with greater than 50% cumulative variance explained. Translatable DMM PCs revealed pathways associated with inflammation, cell signaling, and metabolism, and translatable ACLR PCs represented immune function and other cellular pathways associated with osteoarthritis.</p><p><strong>Conclusions: </strong>Both mouse model more successfully predicted osteoarthritis in human studies with controls without a history of joint pathology. Cross-species, covariate-aware translational approaches support the selection of preclinical models intended for therapeutic discovery and pathway analysis in humans.</p>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12538500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"T2 mapping of the articular cartilage as a biomarker for knee osteoarthritis: An analysis of the population-based Rotterdam Study","authors":"Netanja I. Harlianto ,&nbsp;Jukka Hirvasniemi ,&nbsp;Dirk H.J. Poot ,&nbsp;Stefan Klein ,&nbsp;Sita M.A. Bierma-Zeinstra ,&nbsp;Dieuwke Schiphof ,&nbsp;Edwin H.G. Oei","doi":"10.1016/j.joca.2025.09.009","DOIUrl":"10.1016/j.joca.2025.09.009","url":null,"abstract":"<div><h3>Objective</h3><div>Only few studies have investigated quantitative magnetic resonance imaging (MRI) T₂ mapping of knee cartilage in population-based cohorts. Our objective was to evaluate the association between T₂ relaxation times of different cartilage segments and the presence of knee MRI-based osteoarthritis (OA) and patient characteristics in a large population-based cohort.</div></div><div><h3>Design</h3><div>In this cross-sectional study, we included 673 females (mean age: 59.8 years; standard deviation: 3.7) scanned with 1.5T-MRI from a sub-cohort of the Rotterdam Study. T₂ relaxation times were calculated in six femoral and tibial cartilage regions of interest. Associations between T₂ relaxation times, MRI Osteoarthritis Knee Score (MOAKS)-based tibiofemoral OA, and Knee injury and Osteoarthritis Outcome Score (KOOS)-based symptom status were evaluated using multivariate fixed effects regression analyses.</div></div><div><h3>Results</h3><div>A total of 1332 knees were included, of which 237 (17.7%) had MRI-based OA. Patients with OA had higher T₂ relaxation times across all cartilage segments, and T₂ values positively correlated with BMI (r = 0.17–0.46), the strongest correlations being in the lateral compartment. Weak associations were found between T₂ relaxation times and age. After adjustments, T₂ values in the lateral weight-bearing femur (OR: 0.67; 95%CI: 0.56–0.79), lateral tibia (OR: 1.11; 95%CI: 1.00–1.24), lateral posterior femur (OR: 1.48; 95%CI: 1.28–1.72), and medial posterior femur (OR: 1.14; 95%CI: 1.01–1.30), were associated with the presence of OA. T₂ relaxation times were not associated with the KOOS-based symptom status.</div></div><div><h3>Conclusion</h3><div>In this population-based cohort, T₂ values were associated with BMI. Additionally, T₂ values in the lateral cartilage subregions were associated with MRI-based OA.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 2","pages":"Pages 232-239"},"PeriodicalIF":9.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Entheseal bone remodeling and patient reported outcomes in osteoarthritis – A quantitative [18F]NaF-PET MRI study","authors":"Katharina Ziegeler ,&nbsp;Virginie Kreutzinger ,&nbsp;Lianne S. Gensler ,&nbsp;Rupsa Bhattacharjee ,&nbsp;Misung Han ,&nbsp;Eric Hammond ,&nbsp;Laura Chen ,&nbsp;Emma Bahroos ,&nbsp;Zehra Akkaya ,&nbsp;Thomas M. Link ,&nbsp;Richard B. Souza ,&nbsp;Sharmila Majumdar","doi":"10.1016/j.joca.2025.09.008","DOIUrl":"10.1016/j.joca.2025.09.008","url":null,"abstract":"<div><h3>Objective</h3><div>Entheses have been discussed as potential sources of pain in osteoarthritis (OA). Entheseal bone remodeling quantified by [18F]NaF-PET could be a surrogate marker for tensile forces causing a painful tissue response. This study aimed to investigate the relationship between [18 F]NaF-uptake, MRI findings and knee-related symptoms.</div></div><div><h3>Method</h3><div>Patients and healthy controls in this prospective observational study on patello-femoral OA (PFJOA) underwent simultaneous MR (at 3.0 T) and [18F]NaF PET imaging of both knees. Cartilage damage, subchondral marrow lesions, synovitis, and enthesophytes were semi-quantitatively assessed on MRI and entheseal tracer uptake was quantified in the anterior patella and tibial tuberosity. Symptoms were assessed with the Knee injury and Osteoarthritis Outcome Score (KOOS). Generalized estimating equations were used to investigate associations between tracer uptake and symptoms; analyses were additionally adjusted for MRI-detected changes (as alternative symptom drivers), age, sex and body mass index.</div></div><div><h3>Results</h3><div>A total of 135 knees from 68 subjects were investigated (mean age 48.8 ± 10.4 years; 58.8% women). Higher [18F]NaF-uptake was significantly associated with worse outcomes for KOOS subscales sports (beta −2.7; p&lt;0.001), quality of live (beta 3.0; p&lt;0.001) and PFJ (beta 2.3; p=0.001), but not pain (beta −0.8; p=0.18), symptoms (beta −0.6; p=0.30) or activities of daily living (beta −1.1; p=0.06).</div></div><div><h3>Conclusion</h3><div>Entheseal bone remodeling quantified by [18F]NaF-PET-MRI is associated with patient-reported clinical knee outcomes. These findings underscore the potential of entheseal biology to inform the understanding of symptom generation in degenerative disease of the musculoskeletal system.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"33 12","pages":"Pages 1502-1510"},"PeriodicalIF":9.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter regarding 'A decade of exposure: Long-term air pollution and its impact on osteoarthritis: A nationwide cohort study in Taiwan'.","authors":"Yi-Chuan Chan, Yen-Wei Huang, Shu-Han Chuang, Yi-Jie Kuo, Yu-Pin Chen","doi":"10.1016/j.joca.2025.09.004","DOIUrl":"10.1016/j.joca.2025.09.004","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}