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The Impact of Parental Myopia and High Myopia on the Hyperopia Reserve of Preschool Children. 父母近视和高度近视对学龄前儿童远视储备的影响。
IF 2.1 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2024-01-01 Epub Date: 2023-11-21 DOI: 10.1159/000535193
Jianing Pu, Yuxin Fang, Zhen Zhou, Wei Chen, Jianping Hu, Shanshan Jin, Xinli Liu, Lihua Wang, Jingjing Feng, Huan Tong, Shanshan Xing, Yonghong Jiao

Introduction: The aim of this study was to explore the association between parental myopia and high myopia with children's refraction and ocular biometry in large-scale Chinese preschool children from the Beijing Hyperopia Reserve Study.

Subjects/methods: This cross-sectional kindergarten-based study enrolled children aged 3-6 years. Cycloplegic refraction, axial length (AL), and corneal radius (CR) were measured for all children. Parents were asked to complete a questionnaire about refractive status (no myopia, mild myopia <-3 D, moderate myopia ≥-3 D and ≤-6, and high myopia >-6 D).

Results: The study enrolled 2,053 children (1,069 boys and 984 girls), with a mean age of 4.26 ± 0.96 years and mean spherical equivalent refraction (SER) of 1.11 ± 0.97 diopter. Of the children, 90.7% had at least one myopic parent, and 511 children (24.9%) had at least one highly myopic parent. SER decreased significantly with increasing severity of parental myopia (p < 0.001). Preschool children's myopia was independently associated with parental myopia (OR, 10.4 and 11.5 for one and two highly myopic parent[s]). Age (OR = 1.1), gender (OR = 1.7; girls as references), near work time (OR = 1.2), and both maternal (OR, 1.4 and 2.0 for moderate and high myopia) and paternal myopia (OR, 1.6 and 1.9 for moderate and high myopia) were independent risk factors for lacking hyperopia reserve.

Conclusion: Severe parental myopia was associated with a lower SER, longer AL, and higher AL/CR ratio in preschool children. Parental myopia and near work may predispose children to faster elimination of hyperopia reserves before exposure to higher educational stress.

摘要:本研究旨在通过北京远视储备研究,探讨父母近视和高度近视与儿童屈光和眼部生物特征的关系。对象/方法:本研究以幼儿园为基础,以3-6岁儿童为研究对象。测量所有儿童的睫状体麻痹性屈光、眼轴长度(AL)和角膜半径(CR)。家长被要求填写一份关于屈光状态的问卷(非近视,轻度近视-6D)。结果:共纳入2053例儿童,其中男孩1069例,女孩984例,平均年龄4.26±0.96岁,平均球等效屈光度(SER)为1.11±0.97屈光度。90.7%的儿童至少有一位父母近视,511名儿童(24.9%)至少有一位父母高度近视。结论:学龄前儿童SER降低、AL延长、AL/CR比值升高与父母近视严重程度的增加有关。父母近视和近距离工作可能使孩子在接受更高的教育压力之前更快地消除远视储备。
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引用次数: 0
Differentiating Ischemic Optic Neuropathy from Glaucoma Using Diagnostic Tests. 利用诊断测试区分缺血性视神经病变和青光眼。
IF 2 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2024-01-01 Epub Date: 2024-01-23 DOI: 10.1159/000535568
Frédéric Smeets, Astrid Margot, João Barbosa-Breda, Ingeborg Stalmans, Sophie Lemmens

Introduction: Anterior ischemic optic neuropathy (AION) can mimic glaucoma and consequently cause difficulties in differential diagnosis. The purpose of this paper was to summarize differences in diagnostic tests that can help perform a correct diagnosis.

Methods: The search strategy was performed according to the PRISMA 2009 guidelines, and four databases were used: MEDLINE, Embase, Web of Science, and Cochrane. Totally, 772 references were eligible; 39 were included after screening with respect to inclusion criteria that included English language and published in the 20 years before search date.

Results: Ninety percent (n = 35) of included studies used optical coherence tomography (OCT). Glaucomatous eyes had a significantly greater cup area, volume and depth, cup-to-disk ratio, a lower rim volume and area, and a thinner Bruch's membrane opening-minimum rim width. Retinal nerve fiber layer (RNFL) thinning in glaucomatous eyes occurred primarily at the superotemporal, inferotemporal, and inferonasal sectors, while AION eyes demonstrated mostly superonasal thinning. Glaucoma eyes showed greater macular ganglion cell layer thickness, except at the inferotemporal sector. OCT angiography measurements demonstrated a significant decrease in superficial and deep macular vessel density (VD) in glaucoma compared to AION with similar degree of visual field damage; the parapapillary choroidal VD was spared in AION eyes compared to glaucomatous eyes.

Conclusion: By use of OCT imaging, optic nerve head parameters seem most informative to distinguish between glaucoma and AION. Although both diseases affect the RNFL thickness, it seems to do so in different sectors. Differences in structure and vascularity of the macula can also help in making the differential diagnosis.

简介前部缺血性视神经病变(AION)可与青光眼相似,因此给鉴别诊断带来困难。本文旨在总结诊断测试的差异,以帮助进行正确诊断:方法:根据 PRISMA 2009 指南执行搜索策略,使用了四个数据库:Medline、Embase、Web of Science 和 Cochrane。符合条件的参考文献有 772 篇;根据纳入标准(包括英语和检索日期前 20 年内发表的文献)筛选后,39 篇被纳入:90%(n=35)的纳入研究使用了光学相干断层扫描(OCT)。青光眼患者的杯面积、体积和深度、杯盘比明显增大,边缘体积和面积减小,布氏膜开口-最小边缘宽度变薄。青光眼眼的视网膜神经纤维层(RNFL)变薄主要发生在颞上、颞下和颞下区,而 AION 眼则主要表现为颞上变薄。除颞下部外,青光眼眼的黄斑神经节细胞层厚度更大。OCT血管造影测量显示,在视野(VF)损伤程度相似的情况下,青光眼眼的黄斑浅层和深层血管密度(VD)比AION眼显著降低;与青光眼眼相比,AION眼的毛细血管旁脉络膜VD幸免于难:结论:通过 OCT 成像,视神经头(ONH)参数似乎对区分青光眼和 AION 最有参考价值。虽然这两种疾病都会影响 RNFL 厚度,但似乎影响的部位不同。黄斑结构和血管的差异也有助于做出鉴别诊断。
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引用次数: 0
The p.C759F Variant in USH2A Is a Pathogenic Mutation: Systematic Literature Review and Meta-Analysis of 667 Genotypes. USH2A的p.C759F变异是一种致病性突变:667个基因型的系统文献综述和荟萃分析。
IF 2.1 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2024-01-01 Epub Date: 2023-11-28 DOI: 10.1159/000535545
Ji Hoon Han, Francesca Cancellieri, Irene Perea-Romero, Carmen Ayuso, Mathieu Quinodoz, Carlo Rivolta

Background: Although the p.C759F (c.2276G>T, p.Cys759Phe) variant in the USH2A gene has been identified in association with retinal degeneration by several authors, its pathogenicity has been questioned once by the publication of two unaffected homozygotes from a single family.

Objectives: The objective of the study was to ascertain the role of p.C759F in hereditary retinal disease.

Methods: We examined 87 research articles reporting on patients carrying this variant and then used this information as primary data for a series of meta-analytical tests.

Results: Independent statistical analyses showed that p.C759F (i) is highly enriched in patients with respect to healthy individuals, (ii) represents a clear-cut recessive allele causing disease when it is in trans with other mutations, (iii) is pathogenic in homozygotes.

Conclusions: Our results confirm that p.C759F is a bona fide mutation, leading to retinal blindness according to a recessive pattern of inheritance.

简介:虽然USH2A基因中的p.C759F (c.2276G>T, p.Cys759Phe)变异已被几位作者确定与视网膜变性有关,但其致病性曾因来自一个家族的两个未受影响的纯合子的发表而受到质疑。材料和方法:为了深入了解这种明显的差异,我们检查了87篇报道携带这种变异的患者的研究文章,然后将这些信息作为一系列荟萃分析测试的主要数据。结果和结论:我们的研究结果证实p.C759F是一个真正的突变,根据隐性遗传模式导致视网膜失明。
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引用次数: 0
Visual Outcome after Anti-Vascular Epithelial Growth Factor Therapy Using New Classification of Diabetic Macular Edema by Optical Coherence Tomography. 通过光学相干断层扫描对糖尿病黄斑水肿进行新的分类,了解抗血管内皮生长因子治疗后的视觉效果。
IF 2 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2024-01-01 Epub Date: 2024-08-21 DOI: 10.1159/000539606
Jiawei Zhao, Weiye Zhu, Xiao Cui, Bing Xu, Ni Shen, Hongyuan Song, Wei Shen

Introduction: The aim of the study was to examine alterations in visual acuity in patients with diabetic macular edema (DME), classified according to the TCED-HFV optical coherence tomography (OCT) system, following anti-vascular epithelial growth factor (VEGF) therapy.

Methods: The medical records of patients with DME receiving anti-VEGF therapy were retrospectively reviewed. Patients were divided into four groups according to the TCED-HFV OCT classification. Patient demographic and clinical characteristics and best-corrected visual acuity (BCVA) before and after treatment were compared among the groups.

Results: The BCVA before treatment was 0.49 ± 0.18, 0.81 ± 0.41, 0.83 ± 0.41, and 0.82 ± 0.49 in the early DME, advanced DME, severe DME, and atrophic maculopathy groups, respectively. The BCVA in the early DME group was therefore significantly lower than that in the other three groups (p = 0.042). After treatment, the BCVA improved to 0.15 ± 0.17, 0.52 ± 0.31, 0.62 ± 0.32, and 0.69 ± 0.47 in the early DME, advanced DME, severe DME, and atrophic maculopathy groups, respectively (p < 0.005). There were some differences among patients in the four groups in terms of the duration of diabetes, percentage of hemoglobin A1c, and duration of hypertension.

Conclusion: The TCED-HFV OCT classification of patients with DME is exact and functional and can allow the severity of DME, and its response to anti-VEGF therapy, to be estimated.

简介目的:研究根据TCED-HFV光学相干断层扫描(OCT)系统分类的糖尿病黄斑水肿(DME)患者在接受抗血管上皮生长因子(VEGF)治疗后视力的变化:方法:回顾性审查了接受抗血管内皮生长因子治疗的 DME 患者的病历。根据 TCED-HFV OCT 分类法将患者分为四组。比较各组患者的人口统计学特征、临床特征以及治疗前后的最佳矫正视力(BCVA):结果:早期DME组、晚期DME组、重度DME组和萎缩性黄斑病变组治疗前的BCVA分别为0.49±0.18、0.81±0.41、0.83±0.41和0.82±0.49。因此,早期 DME 组的 BCVA 明显低于其他三组(p = 0.042)。治疗后,早期 DME 组、晚期 DME 组、重度 DME 组和萎缩性黄斑病变组的 BCVA 分别提高到 0.15±0.17、0.52±0.31、0.62±0.32 和 0.69±0.47(P<0.005)。四组患者在糖尿病病程、血红蛋白 A1c 百分比和高血压病程方面存在一些差异:结论:TCED-HFV OCT 对 DME 患者的分类是准确和实用的,可以估计 DME 的严重程度及其对抗 VEGF 治疗的反应。
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引用次数: 0
Three-Year Follow-Up Study Investigating Changes in Retinal Vascular Morphology and the Relationship with Diabetic Retinopathy in Children with Type 1 Diabetes Mellitus. 对 1 型糖尿病患儿视网膜血管形态变化及其与糖尿病视网膜病变关系的三年随访研究。
IF 2 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2024-01-01 Epub Date: 2024-04-26 DOI: 10.1159/000538797
Shuli Chen, Ying Xiao, Lipu Cui, Xinran Qin, Qingyu An, Tianyi Yuan, Yiwei Wu, Qiurong Lin, Yu Qian, Chenhao Yang, Haidong Zou

Introduction: This study aimed to investigate changes in retinal microvascular morphology and associated factors, and their relationship with diabetic retinopathy (DR) in children with type 1 diabetes mellitus (T1DM).

Methods: Thirty-eight children enrolled in this 3-year follow-up study underwent complete ophthalmic examinations including fundus photography. Retinal vascular parameters were measured automatically and compared between baseline and follow-up. Multiple linear regression was used to investigate factors affecting changes in vascular parameters. Binary logistic regression was used to analyze the relationship between retinal microvascular morphology and DR.

Results: The caliber of all retinal vessels (within 1-1.5 papillary diameter [PD] from the center of the optic disc, p = 0.030; 1.5-2 PD, p = 0.003), arterioles, and venules (1.5-2 PD, p = 0.001) was narrower in nearly all regions in the follow-up group compared with the baseline group. Vascular tortuosity increased in the central part of the retina and decreased in the periphery. The density (1-1.5 PD, p = 0.030) and fractal dimension (p = 0.037) of retinal vessels were increased at the end of the follow-up compared with baseline. Retinal vascular caliber was independently correlated with DR (odds ratio 0.793 [95% confidence interval 0.633-0.993]; p = 0.044).

Conclusion: Retinal microvascular morphology in children with T1DM varied with the disease course. Narrower retinal vessels may be an independent risk factor for DR. Results of this study emphasized the importance of regular follow-up of fundus vascular morphology for the detection of early DR in children with T1DM.

简介:本研究旨在调查 1 型糖尿病(T1DM)患儿视网膜微血管形态的变化、相关因素及其与糖尿病视网膜病变(DR)的关系:参加这项为期三年随访研究的 38 名儿童接受了包括眼底照相在内的全面眼科检查。对视网膜血管参数进行了自动测量,并对基线值和随访值进行了比较。多元线性回归用于研究影响血管参数变化的因素。二元逻辑回归用于分析视网膜微血管形态与 DR 之间的关系:结果:与基线组相比,随访组几乎所有区域的视网膜血管(视盘中心乳头直径[PD]1-1.5以内,P = 0.030;1.5-2 PD,P = 0.003)、动脉和静脉(1.5-2 PD,P = 0.001)的口径都变窄了。视网膜中央部位的血管迂曲度增加,周边部位的血管迂曲度减少。与基线相比,随访结束时视网膜血管的密度(1-1.5 PD,P = 0.030)和分形维度(P = 0.037)均有所增加。视网膜血管口径与 DR 独立相关(几率比 0.793 [95% 置信区间 0.633-0.993];P = 0.044):结论:T1DM患儿的视网膜微血管形态随病程而变化。结论:T1DM患儿的视网膜微血管形态随病程而变化,视网膜血管变窄可能是导致DR的一个独立风险因素。本研究结果强调了定期随访眼底血管形态对检测 T1DM 儿童早期 DR 的重要性。
{"title":"Three-Year Follow-Up Study Investigating Changes in Retinal Vascular Morphology and the Relationship with Diabetic Retinopathy in Children with Type 1 Diabetes Mellitus.","authors":"Shuli Chen, Ying Xiao, Lipu Cui, Xinran Qin, Qingyu An, Tianyi Yuan, Yiwei Wu, Qiurong Lin, Yu Qian, Chenhao Yang, Haidong Zou","doi":"10.1159/000538797","DOIUrl":"10.1159/000538797","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate changes in retinal microvascular morphology and associated factors, and their relationship with diabetic retinopathy (DR) in children with type 1 diabetes mellitus (T1DM).</p><p><strong>Methods: </strong>Thirty-eight children enrolled in this 3-year follow-up study underwent complete ophthalmic examinations including fundus photography. Retinal vascular parameters were measured automatically and compared between baseline and follow-up. Multiple linear regression was used to investigate factors affecting changes in vascular parameters. Binary logistic regression was used to analyze the relationship between retinal microvascular morphology and DR.</p><p><strong>Results: </strong>The caliber of all retinal vessels (within 1-1.5 papillary diameter [PD] from the center of the optic disc, p = 0.030; 1.5-2 PD, p = 0.003), arterioles, and venules (1.5-2 PD, p = 0.001) was narrower in nearly all regions in the follow-up group compared with the baseline group. Vascular tortuosity increased in the central part of the retina and decreased in the periphery. The density (1-1.5 PD, p = 0.030) and fractal dimension (p = 0.037) of retinal vessels were increased at the end of the follow-up compared with baseline. Retinal vascular caliber was independently correlated with DR (odds ratio 0.793 [95% confidence interval 0.633-0.993]; p = 0.044).</p><p><strong>Conclusion: </strong>Retinal microvascular morphology in children with T1DM varied with the disease course. Narrower retinal vessels may be an independent risk factor for DR. Results of this study emphasized the importance of regular follow-up of fundus vascular morphology for the detection of early DR in children with T1DM.</p>","PeriodicalId":19662,"journal":{"name":"Ophthalmic Research","volume":" ","pages":"330-339"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparisons of Handheld Retinal Imaging with Optical Coherence Tomography for the Identification of Macular Pathology in Patients with Diabetes. 手持式视网膜成像与光学相干断层扫描在糖尿病患者黄斑病理学鉴定中的比较。
IF 2.1 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2023-01-01 Epub Date: 2023-04-20 DOI: 10.1159/000530720
Cris Martin P Jacoba, Recivall P Salongcay, Abdulrahman K Rageh, Lizzie Anne C Aquino, Glenn P Alog, Aileen V Saunar, Tunde Peto, Paolo S Silva

Introduction: Handheld retinal imaging cameras are relatively inexpensive and highly portable devices that have the potential to significantly expand diabetic retinopathy (DR) screening, allowing a much broader population to be evaluated. However, it is essential to evaluate if these devices can accurately identify vision-threatening macular diseases if DR screening programs will rely on these instruments. Thus, the purpose of this study was to evaluate the detection of diabetic macular pathology using monoscopic macula-centered images using mydriatic handheld retinal imaging compared with spectral domain optical coherence tomography (SDOCT).

Methods: Mydriatic 40°-60° macula-centered images taken with 3 handheld retinal imaging devices (Aurora [AU], SmartScope [SS], RetinaVue 700 [RV]) were compared with the Cirrus 6000 SDOCT taken during the same visit. Images were evaluated for the presence of diabetic macular edema (DME) on monoscopic fundus photographs adapted from Early Treatment Diabetic Retinopathy Study (ETDRS) definitions (no DME, noncenter-involved DME [non-ciDME], and center-involved DME [ciDME]). Sensitivity, specificity, positive predictive value, and negative predictive value were calculated for each device with SDOCT as gold standard.

Results: Severity by ETDRS photos: no DR 33.3%, mild NPDR 20.4%, moderate 14.2%, severe 11.6%, proliferative 20.4%, and ungradable for DR 0%; no DME 83.1%, non-ciDME 4.9%, ciDME 12.0%, and ungradable for DME 0%. Gradable images by SDOCT (N = 217, 96.4%) showed no DME in 75.6%, non-ciDME in 9.8%, and ciDME in 11.1%. The ungradable rate for images (poor visualization in >50% of the macula) was AU: 0.9%, SS: 4.4%, and RV: 6.2%. For DME, sensitivity and specificity were similar across devices (0.5-0.64, 0.93-0.97). For nondiabetic macular pathology (ERM, pigment epithelial detachment, traction retinal detachment) across all devices, sensitivity was low to moderate (0.2-0.5) but highly specific (0.93-1.00).

Conclusions: Compared to SDOCT, handheld macular imaging attained high specificity but low sensitivity in identifying macular pathology. This suggests the importance of SDOCT evaluation for patients suspected to have DME on fundus photography, leading to more appropriate referral refinement.

简介:手持式视网膜成像相机是一种相对便宜且高度便携的设备,有可能显著扩大糖尿病视网膜病变(DR)筛查,从而对更广泛的人群进行评估。然而,如果DR筛查项目将依赖于这些仪器,那么评估这些设备是否能够准确识别威胁视力的黄斑疾病是至关重要的。因此,本研究的目的是评估与光谱域光学相干断层扫描(SDOCT)相比,使用散瞳手持视网膜成像的单视野黄斑中心图像检测糖尿病黄斑病变的效果。方法:将3台手持视网膜成像设备(Aurora[AU]、SmartScope[SS]、RetinaVue700[RV])拍摄的以Mydriatic 40°-60°黄斑为中心的图像与同一次就诊期间拍摄的Cirrus 6000 SDOCT进行比较。根据早期治疗糖尿病视网膜病变研究(ETDRS)的定义(无DME、非中心受累DME[非ciDME]和中心受累DMM[ciDME'),在单视野眼底照片上评估图像是否存在糖尿病黄斑水肿(DME)。以SDOCT为金标准,计算每个装置的灵敏度、特异性、阳性预测值和阴性预测值。结果:ETDRS照片的严重程度:无DR 33.3%,轻度NPDR 20.4%,中度14.2%,重度11.6%,增殖性20.4%,DR不可分级0%;无DME 83.1%,无ciDME 4.9%,ciDME 12.0%,DME 0%不可接受。SDOCT的分级图像(N=217,96.4%)显示75.6%没有DME,9.8%没有ciDME,11.1%有ciDME。图像的不可分级率(黄斑>50%的可视化较差)为AU:0.9%,SS:4.4%和RV:6.2%。对于DME,不同设备的敏感性和特异性相似(0.5-0.64,0.93-0.97)。对于所有设备的非糖尿病性黄斑病变(ERM、色素上皮脱离、牵引性视网膜脱离),敏感性为低至中等(0.2-0.5),但具有高度特异性(0.93-1.00)。结论:与SDOCT相比,手持黄斑成像在识别黄斑病变方面具有高特异性但低灵敏度。这表明SDOCT评估对眼底摄影中怀疑患有DME的患者的重要性,从而导致更适当的转诊细化。
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引用次数: 0
Morphological Characteristics of Foveal Pit Base and Its Impact on Visual Acuity in Macular Pseudoholes. 黄斑假性孔窝底形态特征及其对视觉敏锐性的影响。
IF 2.1 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2023-01-01 Epub Date: 2023-01-30 DOI: 10.1159/000529058
Xiaohan Yang, Xijin Wu, Yanping Yu, Ke Zhang, Biying Qi, Xinbo Wang, Wu Liu

Introduction: To investigate the characteristics of macular pseudoholes (MPHs) with different foveal profiles and their impact on preoperative and postoperative visual acuity (VA).

Methods: A retrospective review of 47 eyes from 46 consecutive patients with MPH who had undergone vitrectomy was conducted. The MPHs were classified into u-shape and v-shape according to the morphological description of the foveola base. The best-corrected visual acuity (BCVA), central foveal point thickness, parafoveal thickness, parafoveal inner and outer retinal thickness, stretched lamellar cleavage, microcystic macular edema (MME), disorganization of retinal inner layers (DRIL), and the integrity of outer retinal layers were recorded.

Results: The eyes in the v-shaped group (n = 31) had lower BCVA, thicker retinal thickness, more intraretinal cleavage, MME, and DRIL than the u-shaped (n = 16) group (all p < 0.05). Multiple regression analysis revealed that the morphology of the foveola base was significantly related to the preoperative BCVA (p = 0.025). The VA was significantly improved in both groups, and the improvement was greater in the v-shaped group (p = 0.024). No significant difference was found in the postoperative BCVA between the two groups (all p > 0.05).

Conclusion: The v-shape, reflecting the stretch in the foveola, had a significant impact on preoperative BCVA. However, the VA was improved after surgery whatever their initial foveal profile.

引言:研究不同中心凹型黄斑假性孔(MPH)的特征及其对术前和术后视力的影响。方法:对46例连续接受玻璃体切除术的MPH患者的47眼进行回顾性分析。根据小凹基部的形态学描述,MPH分为u形和v形。记录最佳矫正视力(BCVA)、中央凹点厚度、凹旁厚度、凹内侧和外侧视网膜厚度、拉伸板层裂、微囊性黄斑水肿(MME)、视网膜内层紊乱(DRIL)和外侧视网膜层完整性。结果:与u型组(n=16)相比,v型组(n=31)的BCVA较低,视网膜厚度较厚,视网膜内裂、MME和DRIL较多(均p<0.05)。多元回归分析显示,小凹基底的形态与术前BCVA显著相关(p=0.025)。两组的VA均显著改善,两组术后BCVA无显著性差异(均p>0.05)。结论:反映小凹拉伸的v型对术前BCVA有显著影响。然而,无论其最初的中央凹轮廓如何,VA在手术后都得到了改善。
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引用次数: 0
The First-Year Variation in Central Retinal Thickness Predicts Legal Blindness in Patients with Neovascular Age-Related Macular Degeneration. 视网膜中央厚度第一年的变化可预测新生血管性老年黄斑变性患者的法定失明。
IF 2.1 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2023-01-01 Epub Date: 2022-11-25 DOI: 10.1159/000528161
Yi Guo, Jinye Wu, Xueying Zheng, Chang Yin, Zhenyu Wu

Introduction: Due to its progressive nature, early evaluation and timely prediction of legal blindness are important in patients with neovascular age-related macular degeneration (nAMD). We examined the association between early-stage variation in central retinal thickness (CRT) and long-term visual outcomes in patients with nAMD.

Methods: We included 103 nAMD patients who were administered anti-vascular endothelial growth factor (anti-VEGF). Participants were considered qualified if they were (1) 50 years and older, (2) treatment-naïve, (3) received standard anti-VEGF treatment and had complete baseline information. We further excluded patients with less than 1-year follow-up data and those who experienced best corrected visual acuity ≤35. Early-stage variability in CRT was measured as the first-year coefficient of variability (CV) of CRT. Patients were then classified into the high-variability and low-variability groups according to the X-tile. A product-limit plot was used to demonstrate the differences and tested with the log-rank test. The association between first-year variability and visual outcomes was quantified using Cox regression models. Time-to-event primary endpoint was the overall visual preservation (OVP) rate, defined as the time from the first injection to legal blindness, i.e., best corrected visual acuity ≤35 Early Treatment Diabetic Retinopathy Study (ETDRS) letters.

Results: A threshold of 20% of first-year CV in CRT was used to categorize 76 qualified patients into high variability (35, 46.1%) and low variability (41, 53.9%). The 5- and 10-year OVPs for patients with high versus low variability were 76% versus 48% and 59% versus 22%, respectively. High early-stage CRT variability showed a significantly higher risk of legal blindness. Even after adjusting for the demographic and clinical features, the variability remained significant (HR = 2.39, 95% CI: 1.20-4.78).

Conclusion: First-year variability of CRT was predictive of long-term visual outcomes in patients with nAMD, and 20% of the variability could be used as a clinically convenient threshold to qualitatively classify patients into high- and low-variability groups. The current study is important for identifying high-risk populations and for long-term disease management.

导言:新生血管性老年性黄斑变性(nAMD)是一种渐进性疾病,因此早期评估和及时预测法定失明对于nAMD患者非常重要。我们研究了视网膜中央厚度(CRT)早期变化与 nAMD 患者长期视觉结果之间的关系:我们纳入了 103 名接受抗血管内皮生长因子(anti-VEGF)治疗的 nAMD 患者。符合以下条件的患者被视为合格患者:(1) 50 岁及以上;(2) 未接受过治疗;(3) 接受过标准抗血管内皮生长因子治疗且基线信息完整。我们进一步排除了随访数据不足 1 年的患者和最佳矫正视力≤35 的患者。CRT 的早期变异性以 CRT 的第一年变异系数 (CV) 来衡量。然后根据 X 分位数将患者分为高变异性组和低变异性组。使用限积图来显示差异,并进行对数秩检验。第一年变异性与视觉结果之间的关系采用 Cox 回归模型进行量化。从时间到事件的主要终点是总体视力保持率(OVP),定义为从首次注射到合法失明(即最佳矫正视力≤35个早期治疗糖尿病视网膜病变研究(ETDRS)字母)的时间:以 CRT 第一年变异率 20% 为临界值,将 76 名合格患者分为高变异率患者(35 人,46.1%)和低变异率患者(41 人,53.9%)。高变异性与低变异性患者的 5 年和 10 年 OVP 分别为 76% 对 48% 和 59% 对 22%。早期 CRT 变异性高的患者合法失明的风险明显更高。即使调整了人口统计学和临床特征,变异性仍然显著(HR = 2.39,95% CI:1.20-4.78):结论:CRT 的第一年变异性可预测 nAMD 患者的长期视觉结果,20% 的变异性可作为临床上方便的阈值,将患者定性地分为高变异性组和低变异性组。目前的研究对于识别高危人群和长期疾病管理非常重要。
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引用次数: 1
8th International Congress of Research in Retina and Vision. 第 8 届国际视网膜和视觉研究大会。
IF 2 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2023-01-01 Epub Date: 2023-05-25 DOI: 10.1159/000531114

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引用次数: 0
Identification of Cuproptosis-Related circRNA-miRNA-mRNA Network in Laser-Induced Choroidal Neovascularization Models and in Peripheral Blood Mononuclear Cells of Patients with Neovascular Age-Related Macular Degeneration. 激光诱导脉络膜新生血管模型和新生血管性年龄相关性黄斑变性患者外周血单个核细胞中铜绿相关环状rna - mirna - mrna网络的鉴定
IF 2.1 4区 医学 Q2 OPHTHALMOLOGY Pub Date : 2023-01-01 Epub Date: 2023-11-21 DOI: 10.1159/000535170
Min Zhang, Jiali Wu, Yafang Wang, Xiaoling Wan, Haiyun Liu, Xiaodong Sun

Introduction: The aims of this study were to investigate the molecular alterations of cuproptosis-related genes and to construct the cuproptosis-related circular RNA (circRNA)-microRNA (miRNA)-mRNA networks in neovascular age-related macular degeneration (nAMD).

Methods: The transcriptional profiles of laser-induced choroid neovascularization (CNV) mouse models and nAMD patient samples were obtained from sequencing and from the GEO database (GSE146887), respectively. The expression levels of ten cuproptosis-related genes (FDX1, DLAT, LIAS, DLD, PDHB, MTF1, CDKN2A, GLS, LIPT1, and PDHA1) were extracted and verified in both mouse CNV models and patient peripheral blood mononuclear cells (PBMCs) samples. The cuproptosis-related circRNA-miRNA-mRNA network was further constructed based on miRNet database, the dataset GSE131646 of small RNA expression profile, and the dataset GSE140178 of circRNA expression profile in mouse CNV models.

Results: The significant upregulation of Cdkn2a and Mtf1 and the downregulation of other 5 cuproptosis-related genes were verified in the mouse CNV model, but only CDKN2A significantly upregulated in PBMCs of patients with nAMD. Four miRNAs were detected in the intersection between miRNet prediction and sequencing data: miR-129-5p, miR-129-2-3p, miR-182-5p, and miR-615-3p. There were 9 circRNAs at the intersection of hsa-miR-182-5p and hsa-miR-615-3p predictions, one circRNA predicted by hsa-miR-129-5p and GSE140178 (hsa-circASH1L), and one circRNA predicted by hsa-miR-182-5p and hsa-miR-615-3p (hsa-circNPEPPS).

Conclusion: This study suggested the repression of cuproptosis in nAMD pathologies and constructed a cuproptosis-related network of 8 cuproptosis-related genes, 4 miRNAs, and 11 circRNAs.

前言:研究新生血管性年龄相关性黄斑变性(nAMD)中铜倾相关基因的分子改变,构建铜倾相关环状rna - mirna - mrna网络。方法:分别从测序和GEO数据库(GSE146887)中获取激光诱导脉络膜新生血管(CNV)小鼠模型和nAMD患者样本的转录谱。提取10个铜裂相关基因(FDX1、DLAT、LIAS、DLD、PDHB、MTF1、CDKN2A、GLS、LIPT1和PDHA1)在小鼠CNV模型和患者外周血单个核细胞(PBMCs)样本中的表达水平并进行验证。基于miRNet数据库、小鼠CNV模型小RNA表达谱数据集GSE131646和小鼠CNV模型circRNA表达谱数据集GSE140178,进一步构建铜喙相关circRNA- mirna - mrna网络。结果:在小鼠CNV模型中证实Cdkn2a和Mtf1显著上调,其他5个铜体相关基因下调,但只有Cdkn2a在nAMD患者的PBMCs中显著上调。在miRNet预测和测序数据的交集中检测到四种mirna: miR-129-5p, miR-129-2-3p, miR-182-5p和miR-615-3p。在hsa-miR-182-5p和hsa-miR-615-3p预测的交叉点上有9个circRNA,一个由hsa-miR-129-5p和GSE140178预测的circRNA (hsa-circASH1L),一个由hsa-miR-182-5p和hsa-miR-615-3p预测的circRNA (hsa-circNPEPPS)。结论:本研究提示铜倾在nAMD病理中具有抑制作用,并构建了一个由8个铜倾相关基因、4个mirna和11个circrna组成的铜倾相关网络。
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引用次数: 0
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Ophthalmic Research
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