Osteoporosis and Sarcopenia最新文献

英文中文

BONEcheck: A digital tool for personalized bone health assessment BONEcheck:用于个性化骨骼健康评估的数字工具

IF 2 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia

Pub Date : 2023-09-01 DOI: 10.1016/j.afos.2023.08.002

Dinh Tan Nguyen , Thao P. Ho-Le , Liem Pham , Vinh P. Ho-Van , Tien Dat Hoang , Thach S. Tran , Steve Frost , Tuan V. Nguyen

Objectives

Osteoporotic fracture is a significant public health burden associated with increased mortality risk and substantial healthcare costs. Accurate and early identification of high-risk individuals and mitigation of their risks is a core part of the treatment and prevention of fractures. Here we introduce a digital tool called 'BONEcheck' for personalized assessment of bone health.

Methods

The development of BONEcheck primarily utilized data from the prospective population-based Dubbo Osteoporosis Epidemiology Study and the Danish Nationwide Registry. BONEcheck has 3 modules: input data, risk estimates, and risk context. Input variables include age, gender, prior fracture, fall incidence, bone mineral density (BMD), comorbidities, and genetic variants associated with BMD.

Results

Based on the input variables, BONEcheck estimates the probability of any fragility fracture and hip fracture within 5 years, subsequent fracture risk, skeletal age, and time to reach osteoporosis. The probability of fracture is shown in both numeric and human icon array formats. The risk is also contextualized within the framework of treatment and management options on Australian guidelines, with consideration given to the potential fracture risk reduction and survival benefits. Skeletal age was estimated as the sum of chronological age and years of life lost due to a fracture or exposure to risk factors that elevate mortality risk.

Conclusions

BONEcheck is an innovative tool that empowers doctors and patients to engage in well-informed discussions and make decisions based on the patient's risk profile. Public access to BONEcheck is available via https://bonecheck.org and in Apple Store (iOS) and Google Play (Android).

骨质疏松性骨折是一种严重的公共卫生负担，与增加的死亡率和高昂的医疗费用有关。准确和早期识别高危个体并降低其风险是骨折治疗和预防的核心部分。在这里，我们介绍一个名为“BONNecheck”的数字工具，用于对骨骼健康进行个性化评估。方法BONNecheck的开发主要利用基于前瞻性人群的Dubbo骨质疏松症流行病学研究和丹麦全国注册中心的数据。BONNecheck有3个模块：输入数据、风险估计和风险背景。输入变量包括年龄、性别、既往骨折、跌倒发生率、骨密度（BMD）、合并症和与BMD相关的遗传变异。结果根据输入变量，BONNecheck估计了5年内发生脆性骨折和髋部骨折的概率、随后的骨折风险、骨龄和达到骨质疏松症的时间。骨折的概率以数字和人体图标数组的形式显示。风险也在澳大利亚指南的治疗和管理选择框架内进行了背景分析，并考虑到潜在的骨折风险降低和生存益处。骨骼年龄估计为实际年龄和因骨折或暴露于增加死亡风险的风险因素而损失的寿命之和。结论ONECheck是一种创新工具，使医生和患者能够进行知情的讨论，并根据患者的风险状况做出决定。公众可通过https://bonecheck.org以及在Apple Store（iOS）和Google Play（Android）中。

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引用次数: 0

The association between masticatory ability and lower Timed Up & Go Test performance among community-dwelling Japanese aging men and women: The Toon Health Study 日本社区老年男性和女性咀嚼能力与较低时间Up & Go测试成绩之间的关系:香椿健康研究

IF 2 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia

Pub Date : 2023-09-01 DOI: 10.1016/j.afos.2023.08.001

Saori Miyazaki , Koutatsu Maruyama , Kiyohide Tomooka , Shinji Nishioka , Noriko Miyoshi , Ryoichi Kawamura , Yasunori Takata , Haruhiko Osawa , Takeshi Tanigawa , Isao Saito

Objectives

Few studies examined the association between deterioration of masticatory ability assessed by objective marker and physical function. Therefore, we examined the association between salivary flow rate which is one of the objective and surrogate marker of masticatory ability and lower Timed Up & Go (TUG) performance which is one of major measurement of physical function among aging Japanese.

Methods

This cross-sectional study enrolled 464 Japanese aged 60–84 years old. Participants chewed tasteless and odorless gum for 5 min, calculated stimulated salivary flow rate (g/min) during all chews. The 3 m TUG was conducted, and 75th percentile value (6.8 s for men and 7.0 s for women) or higher was defined as lower TUG performance. Logistic regression analysis was used to examine the association between stimulated salivary flow rate and lower TUG performance.

Results

We found that the stimulated salivary flow rate tended to be negatively associated with the TUG time. We also observed significant negative association between stimulated salivary flow rate and lower TUG performance; the multivariable-adjusted OR (95% confidence interval, CIs) of lower TUG performance for the highest quartile of stimulated salivary flow rate compared with the lowest quartile was 0.34 (0.16–0.69, P for trend = 0.02). Further adjusting for BMI, the association was attenuated but remaind significant; the OR (95% CIs) in highest quartile was 0.37 (0.18–0.76, P for trend = 0.04).

Conclusions

Higher stimulated salivary flow, which means well masticatory ability, was inversely associated with lower TUG performance in the aging Japanese population.

目的探讨客观指标评价的咀嚼能力退化与躯体功能之间的关系。因此，我们研究了作为咀嚼能力的客观和替代指标之一的唾液流率与较低的time Up &围棋(TUG)表现是日本老年人身体机能的主要测量指标之一。方法本横断面研究纳入了464名年龄在60-84岁的日本人。参与者咀嚼无味和无味的口香糖5分钟，计算所有咀嚼期间的刺激唾液流量(g/min)。进行3米TUG，第75个百分位值(男性6.8秒，女性7.0秒)或更高被定义为较低的TUG表现。采用Logistic回归分析来检验受刺激的唾液流量与较低的TUG性能之间的关系。结果受刺激的唾液流率与TUG时间呈负相关。我们还观察到受刺激的唾液流量与较低的TUG成绩之间存在显著的负相关;刺激唾液流量最高的四分位数与最低的四分位数相比，TUG表现较差的多变量调整OR(95%置信区间，CIs)为0.34 (0.16-0.69,P为趋势= 0.02)。进一步调整BMI，这种关联减弱，但仍然显著;最高四分位数OR (95% ci)为0.37 (0.18-0.76,P为趋势= 0.04)。结论日本老年人群刺激唾液流量越大，咀嚼能力越好，与TUG表现越差呈负相关。

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引用次数: 0

Exploring molecular mechanisms underlying the pathophysiological association between knee osteoarthritis and sarcopenia 探讨膝关节骨关节炎和肌肉减少症之间病理生理关联的分子机制

IF 2 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia

Pub Date : 2023-09-01 DOI: 10.1016/j.afos.2023.08.005

Jiyong Yang , Tao Jiang , Guangming Xu , Shuai Wang , Wengang Liu

Objectives

Accumulating evidence indicates a strong link between knee osteoarthritis (KOA) and sarcopenia. However, the mechanisms involved have not yet been elucidated. This study primarily aims to explore the molecular mechanisms that explain the connection between these 2 disorders.

Methods

The gene expression profiles for KOA and sarcopenia were obtained from the Gene Expression Omnibus database, specifically from GSE55235, GSE169077, and GSE1408. Various bioinformatics techniques were employed to identify and analyze common differentially expressed genes (DEGs) across the 3 datasets. The techniques involved the analysis of Gene Ontology and pathways to enhance understanding, examining protein-protein interaction (PPI) networks, and identifying hub genes. In addition, we constructed the network of interactions between transcription factors (TFs) and genes, the co-regulatory network of TFs and miRNAs for hub genes, and predicted potential drugs.

Results

In total, 14 common DEGs were found between KOA and sarcopenia. Detailed information on biological processes and signaling pathways of common DEGs was obtained through enrichment analysis. After performing PPI network analysis, we discovered 4 hub genes (FOXO3, BCL6, CDKN1A, and CEBPB). Subsequently, we developed coregulatory networks for these hub genes involving TF-gene and TF-miRNA interactions. Finally, we identified 10 potential chemical compounds.

Conclusions

By conducting bioinformatics analysis, our study has successfully identified common gene interaction networks between KOA and sarcopenia. The potential of these findings to offer revolutionary understanding into the common development of these 2 conditions could lead to the identification of valuable targets for therapy.

越来越多的证据表明膝关节骨性关节炎（KOA）和少肌症之间存在着密切的联系。然而，所涉及的机制尚未阐明。本研究主要旨在探索解释这两种疾病之间联系的分子机制。方法从基因表达综合数据库中获得KOA和少肌症的基因表达谱，特别是从GSE55235、GSE169077和GSE1408中获得。采用各种生物信息学技术来识别和分析3个数据集中常见的差异表达基因（DEG）。这些技术包括分析基因本体论和增强理解的途径，检查蛋白质-蛋白质相互作用（PPI）网络，以及识别枢纽基因。此外，我们构建了转录因子（TF）和基因之间的相互作用网络，构建了TF和miRNA对中枢基因的协同调节网络，并预测了潜在的药物。结果KOA与少肌症共发现14个常见的DEG。通过富集分析获得了常见DEG的生物学过程和信号通路的详细信息。在进行PPI网络分析后，我们发现了4个枢纽基因（FOXO3、BCL6、CDKN1A和CEBPB）。随后，我们为这些中枢基因开发了涉及TF基因和TF-miRNA相互作用的协同调节网络。最后，我们确定了10种潜在的化合物。结论通过生物信息学分析，我们的研究成功地确定了KOA与少肌症之间常见的基因相互作用网络。这些发现有可能为这两种疾病的共同发展提供革命性的理解，从而确定有价值的治疗靶点。

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引用次数: 0

Identification of people with high risk of osteoporosis in Asia 亚洲骨质疏松症高危人群的识别

IF 2 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia

Pub Date : 2023-09-01 DOI: 10.1016/j.afos.2023.08.004

Jia Wen Chong, Tik S. Chan, Joseph C. Lee

引用次数: 0

Reply on “Identification of people with high risk of osteoporosis in Asia” 关于“亚洲骨质疏松症高危人群的识别”的复函

IF 2 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia

Pub Date : 2023-09-01 DOI: 10.1016/j.afos.2023.08.003

Ching-Lung Cheung

引用次数: 0

TOC TOC

IF 2 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia

Pub Date : 2023-09-01 DOI: 10.1016/S2405-5255(23)00059-6

引用次数: 0

Illicit drug use is associated with lower bone mineral density and bone strength 非法药物使用与骨密度和骨强度降低有关

IF 2 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia

Pub Date : 2023-09-01 DOI: 10.1016/j.afos.2023.09.001

Suhas Krishnamoorthy , Gloria Hoi-Yee Li , Kelvin Shun-Cheong Ho , Yin-Pan Chau , Constance Mak , Donna Ng , Albert Kar-Kin Chung , Jody Kwok-Pui Chu , Kathryn Choon-Beng Tan , Ruby Lai-Chong Hoo , Ching-Lung Cheung

Objectives

To evaluate the association of illicit drug use with bone mineral density (BMD) and hip geometric parameters at the narrow neck.

Methods

This is a cross-sectional matched cohort study conducted in the Hong Kong Chinese population. Associations with illicit drug use were estimated using linear regression for BMD (lumbar spine and femoral neck) and hip geometrical parameters (cross-sectional area [CSA], cross-sectional moment of inertia [CSMI], section modulus [SM], average cortical thickness [ACT] and BMD at the narrow neck) after adjusting for age, body mass index (BMI), smoking status, drinking status, physical activity, and history of antipsychotic and antidepressant use. Mean difference and 95% confidence intervals (95% CI) were calculated between 108 illicit drug users and 108 controls using an adjusted linear model and cluster-robust standard errors after matching by age and sex. The false discovery rate was used to correct for multiple testing.

Results

Illicit drug users had a significantly lower BMD (g/cm²) at the lumbar spine (mean difference: −0.062; 95% CI: −0.108 to −0.015), and femoral neck (mean difference: −0.058; 95% CI: −0.106 to −0.010) in the fully adjusted model. Illicit drug users also had a significantly lower CSA (mean difference: −0.238 cm²; 95% CI: −0.462 to −0.013), ACT (mean difference: −0.018 cm; 95% CI: −0.030 to −0.006) and BMD (mean difference: −0.070 g/cm²; 95% CI: −0.128 to −0.012) at the narrow neck.

Conclusions

Illicit drug use is associated with lower BMD and bone strength. Future studies evaluating the risk of illicit drug use with fragility fracture are warranted.

目的评估非法药物使用与狭窄颈部骨密度（BMD）和髋关节几何参数的关系。方法对香港华人进行横断面配对队列研究。在对年龄、体重指数（BMI）、吸烟状态、饮酒状态、体育活动、，以及抗精神病药和抗抑郁药使用史。108名非法药物使用者和108名对照者之间的平均差异和95%置信区间（95%CI）是使用调整后的线性模型计算的，并在按年龄和性别匹配后聚类稳健的标准误差。错误发现率用于纠正多次测试。结果在完全调整的模型中，非法吸毒者的腰椎和股骨颈BMD（g/cm2）显著降低（平均差异：-0.062；95%可信区间：-0.108至-0.015）。非法吸毒者在狭窄颈部的CSA（平均差异：−0.238 cm2；95%置信区间：−0.462至−0.013）、ACT（平均差异为：−0.018 cm；95%置信度：−0.030至−0.006）和BMD（平均差异是：−0.070 g/cm2；95%可信区间：−0.128至−0.012）也显著降低。结论利西特药物的使用与骨密度和骨强度降低有关。今后有必要对脆性骨折患者使用非法药物的风险进行评估。

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引用次数: 0

Reply on “teriparatide treatment for postmenopausal women with sacral insufficiency fracture” 关于“特立帕肽治疗绝经后妇女骶骨功能不全骨折”的答复

IF 2 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia

Pub Date : 2023-06-01 DOI: 10.1016/j.afos.2023.05.004

Yao-Chun Yang, Min-Hong Hsieh, Jui-Teng Chien, Keng-Chang Liu, Chang-Chen Yang

引用次数: 0

TOC TOC

IF 2 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia

Pub Date : 2023-06-01 DOI: 10.1016/S2405-5255(23)00038-9

引用次数: 0

Teriparatide treatment for postmenopausal women with sacral insufficiency fracture 特立帕肽治疗绝经后妇女骶骨功能不全骨折

IF 2 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia

Pub Date : 2023-06-01 DOI: 10.1016/j.afos.2023.05.003

Young-Hoon Kim

引用次数: 1

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全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

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全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

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Osteoporosis and Sarcopenia

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