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IF 2 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-03-01 DOI: 10.1016/S2405-5255(23)00017-1
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引用次数: 0
Teriparatide treatment shows faster healing than sacroplasty for postmenopausal women with sacral insufficiency fracture 特立帕肽治疗绝经后骶骨功能不全骨折比骶骨成形术愈合更快
IF 2 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-03-01 DOI: 10.1016/j.afos.2023.02.001
Yao-Chun Yang , Min-Hong Hsieh , Jui-Teng Chien , Keng-Chang Liu , Chang-Chen Yang

Objectives

Sacral insufficiency fracture (SIF) is not an uncommon osteoporosis fracture among the elderly. Aside from traditional treatments, sacroplasty and teriparatide (TPTD) injection have been introduced. This report aims to compare the effects of sacroplasty and teriparatide on clinical outcomes of SIF.

Methods

Thirty-one elderly patients with SIF were enrolled in this retrospective observational study. Four male patients were excluded. Fourteen patients who received TPTD for 6 months were classified into the TPTD group (TT), and 13 who underwent sacroplasty were classified into the sacroplasty group (SS). All patients in both groups were instructed to take calcium and vitamin D supplements daily. Their symptoms and signs, visual analog score (VAS), Oswestry disability index (ODI), and radiographic studies were retrospectively reviewed.

Results

The TT group showed significantly lower VAS than SS group after 3 (P < 0.001) and 6 months of treatment (P < 0.001). The TT group also has significant lower ODI than SS group after 1 (P = 0.010), 3 (P = 0.005) and 6 months (P < 0.001) of treatment. Upon generalized estimating equations (GEE) analysis, the TT group showed significantly more reduction in both VAS and ODI compared to the SS group at 1 month (P = 0.022, P = 0.001), 3 months (P < 0.001, P < 0.001), and 6 months (P < 0.001, P < 0.001) post-treatment.

Conclusions

Postmenoposal woman with SIF who received TPTD healed better than those who underwent sacroplasty after 1 month treatment.

目的老年人骨不全性骨折(SIF)是一种常见的骨质疏松性骨折。除了传统的治疗方法外,还引入了骶成形术和特立帕肽(TPTD)注射。本报告旨在比较骶成形术和特立帕肽对SIF临床结果的影响。方法对31例老年SIF患者进行回顾性观察研究。四名男性患者被排除在外。14名接受TPTD治疗6个月的患者被分为TPTD组(TT),13名接受骶成形术的患者被划分为骶成形术组(SS)。两组的所有患者都被要求每天补充钙和维生素D。对他们的症状和体征、视觉模拟评分(VAS)、奥斯韦斯特里残疾指数(ODI)和放射学研究进行回顾性审查。结果TT组在治疗3个月(P<0.001)和6个月(P<0.001)后VAS评分显著低于SS组,在治疗1个月(P=0.010)、3个月、6个月后ODI评分也明显低于SS组(P<0.005)。根据广义估计方程(GEE)分析,与SS组相比,TT组在治疗后1个月(P=0.022,P=0.001)、3个月(P<;0.001,P<;001)和6个月(P<;0.001,P/lt;0.001)的VAS和ODI均显著降低。结论经TPTD治疗的绝经后SIF患者在治疗1个月后的愈合情况优于经骶成形术的患者。
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引用次数: 1
Exploring optimal supplementation for people with vitamin D deficiency 探索维生素D缺乏症患者的最佳补充剂
IF 2 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-03-01 DOI: 10.1016/j.afos.2023.03.006
Han Seok Choi
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引用次数: 1
The elusive role of myostatin signaling for muscle regeneration and maintenance of muscle and bone homeostasis 肌生长抑制素信号在肌肉再生和维持肌肉和骨骼稳态中的作用
IF 2 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-03-01 DOI: 10.1016/j.afos.2023.03.008
Akash Mitra , Rizwan Qaisar , Bipasha Bose , Sudheer Shenoy P

Skeletal muscle is one of the leading frameworks of the musculo-skeletal system, which works in synergy with the bones. Long skeletal muscles provide stability and mobility to the human body and are primarily composed of proteins. Conversely, improper functioning of various skeletal muscles leads to diseases and disorders, namely, age-related muscle disorder called sarcopenia, a group of genetic muscle disorders such as muscular dystrophies, and severe muscle wasting in cancer known as cachexia. However, skeletal muscle has an excellent ability to undergo hypertrophy and enhanced functioning during sustained exercise over time. Indeed, these processes of skeletal muscle regeneration/hypertrophy, as well as degeneration and atrophy, involve an interplay of various signaling pathways. Myostatin is one such chemokine/myokine with a significant contribution to muscle regeneration or atrophy in multiple conditions. In this review, we try to put together the role and regulation of myostatin as a function of muscle regeneration extrapolated to multiple aspects of its molecular functions.

骨骼肌是肌肉骨骼系统的主要框架之一,与骨骼协同工作。长骨骼肌为人体提供稳定性和灵活性,主要由蛋白质组成。相反,各种骨骼肌的功能失调会导致疾病和病症,即称为少肌症的年龄相关肌肉疾病、一组遗传性肌肉疾病,如肌肉营养不良,以及癌症中称为恶病质的严重肌肉萎缩。然而,随着时间的推移,骨骼肌具有极好的肥大能力,并在持续运动中增强功能。事实上,骨骼肌再生/肥大以及变性和萎缩的这些过程涉及各种信号通路的相互作用。肌抑制素是一种在多种情况下对肌肉再生或萎缩有显著贡献的趋化因子/肌因子。在这篇综述中,我们试图将肌生长抑制素作为肌肉再生功能的作用和调节归纳到其分子功能的多个方面。
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引用次数: 2
Reply on “Inverse correlation of serum uric acid and relative hand grip strength in Korean adult women” 对“韩国成年女性血清尿酸与相对握力的负相关”的回复
IF 2 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-03-01 DOI: 10.1016/j.afos.2023.03.005
Dongwon Yi, Min Jin Lee, Ah Reum Khang, Yang Ho Kang
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引用次数: 0
Inverse correlation of serum uric acid and relative hand grip strength in Korean adult women 韩国成年女性血清尿酸与相对握力的负相关
IF 2 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2023-03-01 DOI: 10.1016/j.afos.2023.03.002
Chang-Hee Suh
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引用次数: 1
Lower SMI is a risk factor for dysphagia in Japanese hospitalized patients with osteoporotic vertebral and hip fracture: A retrospective study 低SMI是日本住院骨质疏松性椎体和髋部骨折患者吞咽困难的危险因素:一项回顾性研究
IF 2 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2022-12-01 DOI: 10.1016/j.afos.2022.11.001
Kaoru Suseki , Masaomi Yamashita , Yoshiaki Kojima , Yojiro Minegishi , Koichiro Komiya , Masashi Takaso

Objectives

Many patients with osteoporotic fragile fracture often suffer from dysphagia that results in malnutrition, further deterioration of physical strength, and rehabilitation difficulties. This study aims to investigate the risk factors for dysphagia in hospitalized patients with osteoporotic vertebral and/or hip fractures.

Methods

Between January 2020 and December 2021, 569 inpatients were managed for osteoporotic vertebral or hip fractures. Of these, 503 patients were analyzed and 66 were excluded as the required data could not be obtained or dysphagia with causative diseases such as cerebrovascular disease. The patients were divided into 2 groups: patients with dysphagia (P-group) and patients without dysphagia (N-group). We investigated gender, fracture site, age, systemic skeletal muscle mass index (SMI), bone mineral density (BMD), and body mass index (BMI) in early stage of hospitalization and studied their relationship with dysphagia.

Results

There were no significant differences in gender and fracture site between the 2 groups. A significant difference was observed in age, SMI, BMD, and BMI (P < 0.01). We performed a logistic regression analysis with the P-group as the objective variable and age, SMI, BMD, and BMI as explanatory variables. We divided objective groups into all patients, patients with vertebral fracture, patients with hip fracture, men, and women. SMI was an independent risk factor in all groups.

Conclusions

Lower SMI was a risk factor for dysphagia in hospitalized patients with osteoporotic vertebral and hip fractures. We carefully observed swallowing function of patients with decreased SMI to maintain the nutritional status and prevent rehabilitation difficulties.

目的许多骨质疏松性脆性骨折患者常伴有吞咽困难,导致营养不良,体力进一步下降,康复困难。本研究旨在探讨骨质疏松性椎体和/或髋部骨折住院患者发生吞咽困难的危险因素。方法:2020年1月至2021年12月,569例骨质疏松性椎体或髋部骨折住院患者接受治疗。其中,503例患者被分析,66例因无法获得所需资料或吞咽困难合并脑血管疾病等致病性疾病而被排除。将患者分为两组:有吞咽困难患者(p组)和无吞咽困难患者(n组)。我们调查了住院早期患者的性别、骨折部位、年龄、全身骨骼肌质量指数(SMI)、骨矿物质密度(BMD)和身体质量指数(BMI),并研究了它们与吞咽困难的关系。结果两组患者性别、骨折部位差异无统计学意义。两组在年龄、重度精神障碍指数(SMI)、骨密度(BMD)和身体质量指数(BMI)方面存在显著差异(P <0.01)。我们以p组为客观变量,以年龄、重度智力指数、骨密度和体重指数为解释变量,进行了逻辑回归分析。我们将目标分组分为所有患者、椎体骨折患者、髋部骨折患者、男性和女性。重度精神障碍是所有组的独立危险因素。结论较慢的重度自杀是骨质疏松性椎体和髋部骨折住院患者发生吞咽困难的危险因素。我们仔细观察SMI降低患者的吞咽功能,以维持营养状态,防止康复困难。
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引用次数: 2
Association between serum uric acid and relative hand grip strength in comparison with metabolic syndrome components 与代谢综合征成分比较,血清尿酸和相对握力之间的关系
IF 2 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2022-12-01 DOI: 10.1016/j.afos.2022.10.001
Dongwon Yi , Min Jin Lee , Ah Reum Khang , Yang Ho Kang

Objectives

To investigate the association between serum uric acid (UA) and relative hand grip strength (HGS) in comparison with metabolic syndrome components.

Methods

We analyzed the data of 5247 Korean adults aged ≥ 20 years (2422 men and 2825 women) who participated in the KNHNES VII (2018).

Results

Among women, relative HGS was significantly lower in participants with hyperuricemia (1.65 ± 0.04) than in those without (1.95 ± 0.01) and was significantly decreased in the highest quartile (4Q: 1.77 ± 0.02) of serum UA compared with that in the lowest quartile (1Q: 1.98 ± 0.02). Among men, relative HGS was lower in participants with hyperuricemia (3.09 ± 0.04 vs. 3.16 ± 0.02) and decreased in 4Q (3.08 ± 0.03) of serum UA compared with that in 1Q (3.15 ± 0.03); however, these results were not statistically significant. In age- and multivariate-adjusted analyses in men, relative HGS was significantly lower in 4Q compared with that in 1Q in model 1 (adjusted for age), but there were no significant differences in model 2 (adjusted for age, BMI, and waist circumference) and model 3 (adjusted for age, BMI, waist circumference, systolic and diastolic blood pressure, fasting blood glucose, triglycerides, and high-density lipoprotein cholesterol). Meanwhile, in women, relative HGS was significantly decreased in 4Q compared with that in 1Q in all models.

Conclusions

A significant inverse correlation was observed between serum UA levels and relative HGS in women, and their significance was maintained even after adjusting for age and metabolic syndrome components.

目的探讨血清尿酸(UA)与相对握力(HGS)的相关性,并与代谢综合征成分进行比较。方法对参加KNHNES VII(2018)的5247名年龄≥20岁的韩国成年人(男性2422人,女性2825人)的数据进行分析。结果在女性中,高尿酸血症组相对HGS(1.65±0.04)显著低于无尿酸血症组(1.95±0.01),血清UA最高四分位数(4Q: 1.77±0.02)显著低于最低四分位数(1Q: 1.98±0.02)。在男性中,高尿酸血症患者的相对HGS较低(3.09±0.04比3.16±0.02),血清UA在第4季度(3.08±0.03)低于第1季度(3.15±0.03);然而,这些结果没有统计学意义。在男性年龄和多变量校正分析中,模型1(年龄校正)中,第4季度相对HGS显著低于第1季度,但模型2(年龄、BMI和腰围校正)和模型3(年龄、BMI、腰围、收缩压和舒张压、空腹血糖、甘油三酯和高密度脂蛋白胆固醇校正)无显著差异。同时,在女性中,所有模型的第4季度相对于第1季度的相对HGS均显著降低。结论女性血清UA水平与相对HGS呈显著负相关,即使在调整年龄和代谢综合征成分后,其显著性仍保持不变。
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引用次数: 3
Nutrition in the prevention and management of sarcopenia - A special focus on Asian Indians 预防和管理肌肉减少症的营养-特别关注亚洲印度人
IF 2 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2022-12-01 DOI: 10.1016/j.afos.2022.12.002
Shinjini Bhattacharya , Rohini Bhadra , Annemie M.W.J. Schols , Ardy van Helvoort , Sucharita Sambashivaiah

Sarcopenia, characterized by loss of muscle mass and strength, is common in advanced old age but can be accelerated by chronic disease, malnutrition and physical inactivity. Early initiation of intervention to achieve and maintain a higher peak muscle mass and strength may allow for prevention or delay of sarcopenia and facilitate independent living even in old age. In this context, malnutrition, a significant contributor to sarcopenia, is often overlooked among the Indian population. Maintenance of an optimal energy and protein balance with adequate physical activity level is essential to preserve physical function in the aging population. However, research on the role of micronutrients in muscle maintenance, is still in its infancy. This narrative review, therefore, aims to explore the current status of International and Indian research on the role of nutrition in sarcopenia mitigation and the way forward.

肌肉减少症的特征是肌肉质量和力量的减少,常见于老年,但慢性疾病、营养不良和缺乏体育活动会加速这种疾病的发生。尽早开始干预,以达到和保持较高的峰值肌肉质量和力量,可以预防或延缓肌肉减少症,并促进即使在老年独立生活。在这种情况下,营养不良,一个重要的贡献者,肌肉减少症,往往被忽视的印度人口。维持最佳的能量和蛋白质平衡以及适当的身体活动水平对于保持老年人的身体机能至关重要。然而,关于微量营养素在肌肉维持中的作用的研究仍处于起步阶段。因此,这篇叙述性综述旨在探讨国际和印度关于营养在缓解肌肉减少症中的作用的研究现状和前进方向。
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引用次数: 4
Treatment adherence and risk of vertebral fracture 治疗依从性与椎体骨折风险
IF 2 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2022-12-01 DOI: 10.1016/j.afos.2022.11.002
Ching-Lung Cheung
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引用次数: 1
期刊
Osteoporosis and Sarcopenia
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