Osteoporosis and Sarcopenia最新文献

英文中文

Fracture risk in Korean postmenopausal women: The influence of BMI, age, and bone density 韩国绝经后妇女骨折风险：BMI、年龄和骨密度的影响

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia

Pub Date : 2025-06-01 DOI: 10.1016/j.afos.2025.03.001

Junghwa Shin , Kwang Yoon Kim , Joo-hyun Park , Sangmi Lee , O Kyu Noh , Yong Jun Choi , Yoon-Sok Chung , Bom-Taeck Kim

Objectives

Fracture risk in postmenopausal women is influenced by bone mineral density (BMD), age, and body mass index (BMI). However, fracture prevention strategies primarily focus on low BMD, often overlooking other key factors.

Methods

This retrospective cohort study analyzed 18,151 Korean postmenopausal women aged 50 or older who underwent dual-energy X-ray absorptiometry (DXA) at Ajou University Hospital from years of 2006–2014. Fracture risk was assessed using multivariable Cox proportional hazard models, adjusted for BMI, BMD, and age.

Results

The median age of the cohort was 59.1 years, and the overall fracture incidence was 2.3 per 1,000 person-years. Fracture risk significantly increased with age, with hazard ratios (HRs) of 1.36 (95% CI: 1.08–1.70) for women aged 60–69 and 2.10% (95% CI: 1.62–2.73) for those aged 70 or older, compared to the reference group (50–59 years). Underweight women exhibited the highest fracture cumulative incidence (3.3%), though their risk increase was not statistically significant. Overweight and obese women demonstrated higher BMD but did not show significant fracture risk reductions.

Conclusions

These findings highlight age as a dominant predictor of fracture risk, while BMI plays a complex, less pronounced role. The discrepancy between osteoporosis prevalence and actual fracture risk, particularly in obese elderly women, suggests limitations in BMD-focused assessments. Simple, measurable parameters like age and BMI should complement BMD in fracture risk evaluation to better target high-risk populations and enhance preventive strategies in clinical practice.

目的绝经后妇女骨折风险受骨密度（BMD）、年龄和体重指数（BMI）的影响。然而，预防骨折的策略主要集中在低骨密度上，往往忽略了其他关键因素。方法回顾性队列研究分析了2006-2014年在亚洲大学医院接受双能x线吸收仪（DXA）检查的18151名50岁及以上的韩国绝经后妇女。采用多变量Cox比例风险模型评估骨折风险，并根据BMI、BMD和年龄进行调整。结果该队列的中位年龄为59.1岁，总体骨折发生率为每1000人年2.3例。与参照组（50-59岁）相比，60-69岁女性的骨折风险显著增加，风险比（hr）为1.36 (95% CI: 1.08-1.70)， 70岁及以上女性的风险比（hr）为2.10% （95% CI: 1.62-2.73）。体重过轻的女性骨折累积发生率最高（3.3%），尽管她们的风险增加没有统计学意义。超重和肥胖的女性表现出更高的骨密度，但没有显示出明显的骨折风险降低。这些发现强调年龄是骨折风险的主要预测因素，而BMI则起着复杂但不太明显的作用。骨质疏松症患病率与实际骨折风险之间的差异，特别是在肥胖老年妇女中，表明以bmd为重点的评估存在局限性。在骨折风险评估中，年龄、BMI等简单、可测量的参数应作为BMD的补充，以更好地针对高危人群，并在临床实践中加强预防策略。

{"title":"Fracture risk in Korean postmenopausal women: The influence of BMI, age, and bone density","authors":"Junghwa Shin , Kwang Yoon Kim , Joo-hyun Park , Sangmi Lee , O Kyu Noh , Yong Jun Choi , Yoon-Sok Chung , Bom-Taeck Kim","doi":"10.1016/j.afos.2025.03.001","DOIUrl":"10.1016/j.afos.2025.03.001","url":null,"abstract":"<div><h3>Objectives</h3><div>Fracture risk in postmenopausal women is influenced by bone mineral density (BMD), age, and body mass index (BMI). However, fracture prevention strategies primarily focus on low BMD, often overlooking other key factors.</div></div><div><h3>Methods</h3><div>This retrospective cohort study analyzed 18,151 Korean postmenopausal women aged 50 or older who underwent dual-energy X-ray absorptiometry (DXA) at Ajou University Hospital from years of 2006–2014. Fracture risk was assessed using multivariable Cox proportional hazard models, adjusted for BMI, BMD, and age.</div></div><div><h3>Results</h3><div>The median age of the cohort was 59.1 years, and the overall fracture incidence was 2.3 per 1,000 person-years. Fracture risk significantly increased with age, with hazard ratios (HRs) of 1.36 (95% CI: 1.08–1.70) for women aged 60–69 and 2.10% (95% CI: 1.62–2.73) for those aged 70 or older, compared to the reference group (50–59 years). Underweight women exhibited the highest fracture cumulative incidence (3.3%), though their risk increase was not statistically significant. Overweight and obese women demonstrated higher BMD but did not show significant fracture risk reductions.</div></div><div><h3>Conclusions</h3><div>These findings highlight age as a dominant predictor of fracture risk, while BMI plays a complex, less pronounced role. The discrepancy between osteoporosis prevalence and actual fracture risk, particularly in obese elderly women, suggests limitations in BMD-focused assessments. Simple, measurable parameters like age and BMI should complement BMD in fracture risk evaluation to better target high-risk populations and enhance preventive strategies in clinical practice.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 2","pages":"Pages 65-68"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Special issue on sarcopenia: Asia-Pacific perspectives 肌肉减少症特刊：亚太视角

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia

Pub Date : 2025-06-01 DOI: 10.1016/j.afos.2025.06.002

Sumito Ogawa

引用次数: 0

Epidemiology of sarcopenia: A narrative review 肌肉减少症的流行病学：一个叙述性的回顾

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia

Pub Date : 2025-06-01 DOI: 10.1016/j.afos.2025.06.003

Tzu-Hao Tseng , Shau-Huai Fu , Ning-Huei Sie , Yi-Chien Lu , Chen-Yu Wang , Chih-Hsing Wu

Sarcopenia is a progressive loss of skeletal muscle mass and strength that contributes to adverse outcomes such as falls, fractures, and mortality in aging populations. Its prevalence varies widely across studies, influenced by intrinsic factors (eg, age, comorbidities, lifestyle), environmental conditions (eg, urban–rural differences, institutionalization), and the diagnostic criteria applied. This review synthesizes evidence mainly from systematic reviews and meta-analyses to examine how these factors shape the epidemiology of sarcopenia. The use of different definitions, such as EWGSOP 1/2, AWGS 2014/2019, IWGS, and FNIH, leads to large variations in prevalence estimates. This limits regional comparisons and hampers surveillance. The review also highlights key risk factors such as physical inactivity, malnutrition, smoking, irregular sleep, and cognitive impairment, although the overall certainty of evidence remains low to moderate. These findings emphasize the need for harmonized diagnostic standards and greater methodological consistency in future studies. Clinically, integrating sarcopenia screening into routine care and implementing targeted lifestyle interventions may help reduce disease burden. Future longitudinal and interventional research is essential to clarify causal pathways and guide effective public health strategies for sarcopenia prevention and management.

骨骼肌减少症是一种骨骼肌质量和力量的进行性损失，可导致老年人跌倒、骨折和死亡等不良后果。其患病率在各研究中差异很大，受内在因素（如年龄、合并症、生活方式）、环境条件（如城乡差异、制度化）和适用的诊断标准的影响。本综述综合了主要来自系统综述和荟萃分析的证据，以研究这些因素如何影响肌肉减少症的流行病学。使用不同的定义，如EWGSOP 1/2、AWGS 2014/2019、IWGS和FNIH，导致患病率估计存在很大差异。这限制了地区间的比较，也阻碍了监督。该综述还强调了主要的风险因素，如缺乏身体活动、营养不良、吸烟、睡眠不规律和认知障碍，尽管证据的总体确定性仍然较低至中等。这些发现强调了在未来的研究中需要统一的诊断标准和更大的方法一致性。在临床上，将肌肉减少症筛查纳入常规护理并实施有针对性的生活方式干预可能有助于减轻疾病负担。未来的纵向和干预性研究对于阐明肌肉减少症的病因途径和指导有效的预防和管理公共卫生策略至关重要。

{"title":"Epidemiology of sarcopenia: A narrative review","authors":"Tzu-Hao Tseng , Shau-Huai Fu , Ning-Huei Sie , Yi-Chien Lu , Chen-Yu Wang , Chih-Hsing Wu","doi":"10.1016/j.afos.2025.06.003","DOIUrl":"10.1016/j.afos.2025.06.003","url":null,"abstract":"<div><div>Sarcopenia is a progressive loss of skeletal muscle mass and strength that contributes to adverse outcomes such as falls, fractures, and mortality in aging populations. Its prevalence varies widely across studies, influenced by intrinsic factors (eg, age, comorbidities, lifestyle), environmental conditions (eg, urban–rural differences, institutionalization), and the diagnostic criteria applied. This review synthesizes evidence mainly from systematic reviews and meta-analyses to examine how these factors shape the epidemiology of sarcopenia. The use of different definitions, such as EWGSOP 1/2, AWGS 2014/2019, IWGS, and FNIH, leads to large variations in prevalence estimates. This limits regional comparisons and hampers surveillance. The review also highlights key risk factors such as physical inactivity, malnutrition, smoking, irregular sleep, and cognitive impairment, although the overall certainty of evidence remains low to moderate. These findings emphasize the need for harmonized diagnostic standards and greater methodological consistency in future studies. Clinically, integrating sarcopenia screening into routine care and implementing targeted lifestyle interventions may help reduce disease burden. Future longitudinal and interventional research is essential to clarify causal pathways and guide effective public health strategies for sarcopenia prevention and management.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 2","pages":"Pages 11-21"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Definition and diagnosis of sarcopenia: Asia-Pacific perspectives 肌少症的定义和诊断：亚太地区的观点

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia

Pub Date : 2025-06-01 DOI: 10.1016/j.afos.2025.05.004

Wei-Fu Huang , Ying-Chen Chen , Chin-Sung Chang , Chih-Hsing Wu

Sarcopenia is a progressive, age-related condition characterized by the loss of skeletal muscle mass, strength, and function. As Asia faces rapid population aging, sarcopenia has become an urgent public health concern. Over time, definitions and diagnostic criteria have evolved to emphasize muscle strength and physical performance rather than muscle mass alone. This review summarizes key updates in global and regional frameworks, including guidelines from the European Working Group on Sarcopenia in Older People (EWGSOP2) and the Asian Working Group for Sarcopenia (AWGS 2019). However, these strategies might be updated along with the release of AWGS 2025.

We also review current methods for evaluating muscle health. Although dual-energy X-ray absorptiometry (DXA) remains a standard, it has limitations in reflecting true muscle quality and predicting outcomes. Novel techniques like deuterium-labeled creatine dilution show promise for more accurate assessment. The review highlights emerging muscle-related biomarkers—myokines such as interleukin-6 (IL-6), insulin-like growth factor-1 (IGF-1), irisin, myostatin, and gelsolin—which may improve diagnostic precision and therapeutic strategies.

The Global Leadership Initiative on Sarcopenia (GLIS) introduced the first globally endorsed definition, incorporating muscle mass, strength, muscle-specific strength, and physical performance as a key outcome in 2024. This unified approach supports standardized diagnosis across clinical and research settings. Addressing sarcopenia alongside other age-related conditions is essential to prevent frailty and disability. Finally, the targeted multidomain interventions—particularly physical activity and nutrition—are critical for preserving function and quality of life in older adults.

骨骼肌减少症是一种进行性的、与年龄相关的疾病，其特征是骨骼肌质量、力量和功能的丧失。随着亚洲面临快速的人口老龄化，肌肉减少症已成为一个紧迫的公共卫生问题。随着时间的推移，定义和诊断标准已经发展到强调肌肉力量和身体表现，而不仅仅是肌肉质量。本综述总结了全球和区域框架的关键更新，包括欧洲老年人肌肉减少症工作组（EWGSOP2）和亚洲肌肉减少症工作组（AWGS 2019）的指南。然而，这些策略可能会随着AWGS 2025的发布而更新。我们还回顾了目前评估肌肉健康的方法。虽然双能x线吸收仪（DXA）仍然是一种标准，但它在反映真实肌肉质量和预测结果方面存在局限性。像氘标记肌酸稀释这样的新技术有望进行更准确的评估。该综述强调了新兴的肌肉相关生物标志物-肌肉因子，如白细胞介素-6 （IL-6）、胰岛素样生长因子-1 （IGF-1）、鸢尾素、肌肉生长抑制素和凝胶素-可以提高诊断精度和治疗策略。肌少症全球领导力倡议（GLIS）推出了首个全球认可的定义，将肌肉质量、力量、肌肉特定力量和身体表现作为2024年的关键成果。这种统一的方法支持跨临床和研究设置的标准化诊断。解决肌肉减少症和其他与年龄相关的疾病对于预防虚弱和残疾至关重要。最后，有针对性的多领域干预——特别是身体活动和营养——对于保持老年人的功能和生活质量至关重要。

{"title":"Definition and diagnosis of sarcopenia: Asia-Pacific perspectives","authors":"Wei-Fu Huang , Ying-Chen Chen , Chin-Sung Chang , Chih-Hsing Wu","doi":"10.1016/j.afos.2025.05.004","DOIUrl":"10.1016/j.afos.2025.05.004","url":null,"abstract":"<div><div>Sarcopenia is a progressive, age-related condition characterized by the loss of skeletal muscle mass, strength, and function. As Asia faces rapid population aging, sarcopenia has become an urgent public health concern. Over time, definitions and diagnostic criteria have evolved to emphasize muscle strength and physical performance rather than muscle mass alone. This review summarizes key updates in global and regional frameworks, including guidelines from the European Working Group on Sarcopenia in Older People (EWGSOP2) and the Asian Working Group for Sarcopenia (AWGS 2019). However, these strategies might be updated along with the release of AWGS 2025.</div><div>We also review current methods for evaluating muscle health. Although dual-energy X-ray absorptiometry (DXA) remains a standard, it has limitations in reflecting true muscle quality and predicting outcomes. Novel techniques like deuterium-labeled creatine dilution show promise for more accurate assessment. The review highlights emerging muscle-related biomarkers—myokines such as interleukin-6 (IL-6), insulin-like growth factor-1 (IGF-1), irisin, myostatin, and gelsolin—which may improve diagnostic precision and therapeutic strategies.</div><div>The Global Leadership Initiative on Sarcopenia (GLIS) introduced the first globally endorsed definition, incorporating muscle mass, strength, muscle-specific strength, and physical performance as a key outcome in 2024. This unified approach supports standardized diagnosis across clinical and research settings. Addressing sarcopenia alongside other age-related conditions is essential to prevent frailty and disability. Finally, the targeted multidomain interventions—particularly physical activity and nutrition—are critical for preserving function and quality of life in older adults.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 2","pages":"Pages 2-10"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventative approaches to falls and frailty 预防跌倒和虚弱的方法

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia

Pub Date : 2025-06-01 DOI: 10.1016/j.afos.2025.04.002

Seiji Hashimoto, Tatsuya Hosoi, Mitsutaka Yakabe, Makoto Yunoki, Shoya Matsumoto, Yoshitaka Kase, Masashi Miyawaki, Masaki Ishii, Sumito Ogawa

With increasing life expectancy, the aging population grows, leading to more age-related diseases. Among these, falls are a serious public health issue, as they cause disability in older adults and impose a significant burden both on caregivers and society. Despite numerous studies on fall risk and prevention, the incidence of falls among older adults has not shown any significant improvement. Given the multifactorial nature of falls, it is necessary to evaluate risk factors comprehensively. Recently, the Comprehensive Geriatric Assessment, a tool for comprehensively evaluating older adults, has been reported to help prevent falls and improve postfall outcomes. Assessing individual risks and effectively integrating exercise, nutrition, and appropriate medication management into multifactorial interventions is essential for developing effective fall prevention strategies.

随着预期寿命的延长，老龄化人口的增长，导致更多的与年龄有关的疾病。其中，跌倒是一个严重的公共卫生问题，因为它会导致老年人残疾，并给护理者和社会造成重大负担。尽管有许多关于跌倒风险和预防的研究，老年人跌倒的发生率并没有显示出任何显著的改善。鉴于跌倒的多因素性质，有必要综合评估危险因素。最近，综合老年评估（Comprehensive Geriatric Assessment）——一种全面评估老年人的工具——被报道有助于预防跌倒和改善跌倒后的预后。评估个体风险并将运动、营养和适当的药物管理有效地整合到多因素干预措施中，对于制定有效的跌倒预防策略至关重要。

引用次数: 0

Sarcopenia prevention in older adults: Effectiveness and limitations of non-pharmacological interventions 老年人肌肉减少症的预防：非药物干预的有效性和局限性

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia

Pub Date : 2025-06-01 DOI: 10.1016/j.afos.2025.05.005

Doyoon Kim , Satoru Morikawa , Masashi Miyawaki , Taneaki Nakagawa , Sumito Ogawa , Yoshitaka Kase

Sarcopenia is characterized by a decline in skeletal muscle mass, strength, and physical performance in older adults and is associated with reduced quality of life, an increased risk of requiring long-term care, and a significant economic burden on both patients and their families. In the context of global population aging, sarcopenia presents substantial health and social challenges. However, no effective pharmacological treatment has been established to date, and current management relies on non-pharmacological interventions. This review provides an overview of the most recent evidence on exercise, nutrition, and electrical muscle stimulation (EMS) as strategies to prevent the onset and progression of sarcopenia and discusses their effectiveness and limitations. Although the effectiveness of resistance training, alone or in combination with multicomponent exercise, has been demonstrated, the benefits of nutritional interventions and EMS remain limited. From a pathophysiological perspective, chronic inflammation has been identified as a key contributor to sarcopenia progression and is increasingly considered a potential therapeutic target. This review underscores the significance of a comprehensive intervention strategy tailored to the needs of the older population.

骨骼肌减少症的特点是老年人骨骼肌质量、力量和身体机能下降，与生活质量下降、需要长期护理的风险增加以及患者及其家庭的重大经济负担有关。在全球人口老龄化的背景下，肌肉减少症带来了巨大的健康和社会挑战。然而，迄今为止尚未建立有效的药物治疗方法，目前的管理依赖于非药物干预。本文综述了运动、营养和肌肉电刺激（EMS）作为预防肌少症发生和发展的策略的最新证据，并讨论了它们的有效性和局限性。虽然阻力训练的有效性，单独或与多组分运动相结合，已被证明，营养干预和EMS的好处仍然有限。从病理生理学的角度来看，慢性炎症已被确定为肌肉减少症进展的关键因素，并且越来越被认为是潜在的治疗靶点。这篇综述强调了针对老年人口需求制定综合干预策略的重要性。

{"title":"Sarcopenia prevention in older adults: Effectiveness and limitations of non-pharmacological interventions","authors":"Doyoon Kim , Satoru Morikawa , Masashi Miyawaki , Taneaki Nakagawa , Sumito Ogawa , Yoshitaka Kase","doi":"10.1016/j.afos.2025.05.005","DOIUrl":"10.1016/j.afos.2025.05.005","url":null,"abstract":"<div><div>Sarcopenia is characterized by a decline in skeletal muscle mass, strength, and physical performance in older adults and is associated with reduced quality of life, an increased risk of requiring long-term care, and a significant economic burden on both patients and their families. In the context of global population aging, sarcopenia presents substantial health and social challenges. However, no effective pharmacological treatment has been established to date, and current management relies on non-pharmacological interventions. This review provides an overview of the most recent evidence on exercise, nutrition, and electrical muscle stimulation (EMS) as strategies to prevent the onset and progression of sarcopenia and discusses their effectiveness and limitations. Although the effectiveness of resistance training, alone or in combination with multicomponent exercise, has been demonstrated, the benefits of nutritional interventions and EMS remain limited. From a pathophysiological perspective, chronic inflammation has been identified as a key contributor to sarcopenia progression and is increasingly considered a potential therapeutic target. This review underscores the significance of a comprehensive intervention strategy tailored to the needs of the older population.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 2","pages":"Pages 65-72"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Femoral bone mineral density reference values by sex and ethnicity: Findings from the Qatar Biobank study 性别和种族的股骨骨密度参考值：来自卡塔尔生物银行研究的结果

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia

Pub Date : 2025-06-01 DOI: 10.1016/j.afos.2025.05.006

Fawziya Al-Baker , Mujahed Shraim , Amal Al-Haidose , Atiyeh M. Abdallah

Objectives

Low bone mineral density (BMD) is a major global health concern due to fracture-related morbidity and mortality. BMD is currently assessed by dual-energy X-ray absorptiometry (DXA) against a US reference population. The aim of the study was to establish an ethnicity- and sex-specific reference for calculating BMD at different femoral sites including femoral trochanter, Ward's triangle and femoral neck in Qatar.

Methods

This cross-sectional study analyzed BMD in 4727 (2277 females and 2450 males) healthy Qatari aged between 20 and 82 years participating in the Qatar Biobank (QBB) study. Standard T-scores provided by the densitometer (T_DXA) were compared with ethnicity- and sex-specific T-scores for the Qatari population (T_QA) calculated using data from the 20-29-year age group for different femoral sites as the reference. The concordance between T_DXA and T_QA was analyzed using kappa statistics.

Results

Males consistently exhibited higher BMD values for the femoral trochanter, Ward's triangle, and the femoral neck across all age groups compared with females. Using T_QA rather than T_DXA as a reference at any site classified fewer individuals as having osteoporosis and osteopenia, especially for females. Agreement between T_DXA and T_QA was higher in males than in females.

Conclusions

These findings underscore the need for local ethnicity- and sex-specific BMD reference values. The use of T_QA significantly reduced overdiagnosis of osteopenia and osteoporosis compared with T_DXA, thereby decreasing overtreatment and impacting participant recruitment decisions into clinical studies.

由于骨折相关的发病率和死亡率，低骨密度（BMD）是一个主要的全球健康问题。目前，BMD是通过双能x射线吸收仪（DXA）对美国参考人群进行评估的。该研究的目的是建立一个种族和性别特定的参考，用于计算不同股骨部位的骨密度，包括股骨粗隆、沃德三角和卡塔尔的股骨颈。方法本横断面研究分析了4727名（2277名女性和2450名男性）参加卡塔尔生物银行（QBB）研究的年龄在20至82岁之间的健康卡塔尔人的骨密度。将密度计（TDXA）提供的标准t评分与卡塔尔人口（TQA）的种族和性别特异性t评分进行比较，TQA使用20-29岁年龄组不同股骨部位的数据作为参考。采用kappa统计分析TDXA与TQA的一致性。结果在所有年龄组中，男性股骨粗隆、沃德三角和股骨颈的骨密度值均高于女性。在任何地点使用TQA而不是TDXA作为参考，将更少的个体分类为骨质疏松症和骨质减少症，尤其是女性。TDXA和TQA在男性中的一致性高于女性。结论：这些发现强调了对当地种族和性别特异性骨密度参考值的需求。与TDXA相比，TQA的使用显著减少了骨质减少和骨质疏松的过度诊断，从而减少了过度治疗，影响了临床研究中参与者的招募决策。

{"title":"Femoral bone mineral density reference values by sex and ethnicity: Findings from the Qatar Biobank study","authors":"Fawziya Al-Baker , Mujahed Shraim , Amal Al-Haidose , Atiyeh M. Abdallah","doi":"10.1016/j.afos.2025.05.006","DOIUrl":"10.1016/j.afos.2025.05.006","url":null,"abstract":"<div><h3>Objectives</h3><div>Low bone mineral density (BMD) is a major global health concern due to fracture-related morbidity and mortality. BMD is currently assessed by dual-energy X-ray absorptiometry (DXA) against a US reference population. The aim of the study was to establish an ethnicity- and sex-specific reference for calculating BMD at different femoral sites including femoral trochanter, Ward's triangle and femoral neck in Qatar.</div></div><div><h3>Methods</h3><div>This cross-sectional study analyzed BMD in 4727 (2277 females and 2450 males) healthy Qatari aged between 20 and 82 years participating in the Qatar Biobank (QBB) study. Standard T-scores provided by the densitometer (T<sub>DXA</sub>) were compared with ethnicity- and sex-specific T-scores for the Qatari population (T<sub>QA</sub>) calculated using data from the 20-29-year age group for different femoral sites as the reference. The concordance between T<sub>DXA</sub> and T<sub>QA</sub> was analyzed using kappa statistics.</div></div><div><h3>Results</h3><div>Males consistently exhibited higher BMD values for the femoral trochanter, Ward's triangle, and the femoral neck across all age groups compared with females. Using T<sub>QA</sub> rather than T<sub>DXA</sub> as a reference at any site classified fewer individuals as having osteoporosis and osteopenia, especially for females. Agreement between T<sub>DXA</sub> and T<sub>QA</sub> was higher in males than in females.</div></div><div><h3>Conclusions</h3><div>These findings underscore the need for local ethnicity- and sex-specific BMD reference values. The use of T<sub>QA</sub> significantly reduced overdiagnosis of osteopenia and osteoporosis compared with T<sub>DXA</sub>, thereby decreasing overtreatment and impacting participant recruitment decisions into clinical studies.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 2","pages":"Pages 43-49"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FM - Editorial Board FM -编委会

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia

Pub Date : 2025-03-01 DOI: 10.1016/S2405-5255(25)00008-1

引用次数: 0

Dental panoramic radiographs by dental students versus artificial intelligence 牙科学生的牙科全景x光片与人工智能

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia

Pub Date : 2025-03-01 DOI: 10.1016/j.afos.2025.02.002

Yoon-Sok Chung

引用次数: 0

Comparing mortality rates, risk, and trends of hip fracture and common cancers in Hong Kong, 2010–2020: A population-based study 比较 2010-2020 年香港髋部骨折和常见癌症的死亡率、风险和趋势：以人口为基础的研究

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Osteoporosis and Sarcopenia

Pub Date : 2025-03-01 DOI: 10.1016/j.afos.2024.12.001

Xiaowen Zhang , Chor-Wing Sing , Philip CM Au , Kathryn Choon-Beng Tan , Ian Chi-Kei Wong , Ching-Lung Cheung

Objectives

Hip fracture is a global public concern exhibiting high mortality rates but often underrecognized. We compared the mortality rates, risk, and secular trend of hip fractures with common cancers in females and males, aiming to call attention to hip fractures.

Methods

In 2010–2020, 193,767 patients with the first diagnosed hip fractures and the top 5 prevalent cancers in each sex and aged 50 years and above were included. Age-standardized mortality rates were adjusted to the WHO Standard Population and the sex-specific relative risk of mortality was computed using Cox proportional hazards models, adjusted for potential confounders. The trend analyses used joinpoint regression to compute annual percent changes in age-standardized mortality rates.

Results

The 1-year and 5-year age-standardized mortality rates and sex-specific mortality risk of hip fracture are greater than those of breast cancer (hazard ratio [HR]: 0.93, 95% confidence interval [CI]: 0.90 to 0.97) and thyroid cancer (HR: 0.55, 95% CI: 0.47 to 0.64) in females and prostate cancer (HR: 0.56, 95% CI: 0.53 to 0.58) in males. Moreover, mortality rates in lung cancer, male liver cancer, female breast cancer, and male prostate cancer have decreased in the past decade. For hip fracture, the mortality rates have significantly decreased in females, while in males, we observed only a decreasing trend in 1-year hip fracture mortality, not in 5-year

Conclusions

Hip fractures exhibit higher mortality compared to female breast and thyroid cancers and male prostate cancer. More attention is needed to enhance the management and prevention of hip fractures.

髋部骨折是全球关注的高死亡率疾病，但往往未得到充分认识。我们比较了女性和男性髋部骨折与常见癌症的死亡率、风险和长期趋势，旨在引起人们对髋部骨折的关注。方法纳入2010-2020年首次诊断为髋部骨折的患者193,767例，各性别、年龄在50岁及以上。将年龄标准化死亡率调整为WHO标准人群，使用Cox比例风险模型计算特定性别的死亡率相对风险，并对潜在混杂因素进行调整。趋势分析使用连接点回归来计算年龄标准化死亡率的年百分比变化。结果髋部骨折的1年和5年年龄标准化死亡率和性别特异性死亡率高于女性乳腺癌（风险比[HR]: 0.93, 95%可信区间[CI]: 0.90 ~ 0.97）、甲状腺癌（HR: 0.55, 95% CI: 0.47 ~ 0.64）和男性前列腺癌（HR: 0.56, 95% CI: 0.53 ~ 0.58）。此外，肺癌、男性肝癌、女性乳腺癌和男性前列腺癌的死亡率在过去十年中有所下降。对于髋部骨折，女性的死亡率有明显下降，而在男性中，我们观察到只有1年髋部骨折死亡率有下降趋势，而5年髋部骨折死亡率没有下降趋势。结论与女性乳腺癌、甲状腺癌和男性前列腺癌相比，骨折死亡率更高。加强髋部骨折的管理和预防需要更多的关注。

{"title":"Comparing mortality rates, risk, and trends of hip fracture and common cancers in Hong Kong, 2010–2020: A population-based study","authors":"Xiaowen Zhang , Chor-Wing Sing , Philip CM Au , Kathryn Choon-Beng Tan , Ian Chi-Kei Wong , Ching-Lung Cheung","doi":"10.1016/j.afos.2024.12.001","DOIUrl":"10.1016/j.afos.2024.12.001","url":null,"abstract":"<div><h3>Objectives</h3><div>Hip fracture is a global public concern exhibiting high mortality rates but often underrecognized. We compared the mortality rates, risk, and secular trend of hip fractures with common cancers in females and males, aiming to call attention to hip fractures.</div></div><div><h3>Methods</h3><div>In 2010–2020, 193,767 patients with the first diagnosed hip fractures and the top 5 prevalent cancers in each sex and aged 50 years and above were included. Age-standardized mortality rates were adjusted to the WHO Standard Population and the sex-specific relative risk of mortality was computed using Cox proportional hazards models, adjusted for potential confounders. The trend analyses used joinpoint regression to compute annual percent changes in age-standardized mortality rates.</div></div><div><h3>Results</h3><div>The 1-year and 5-year age-standardized mortality rates and sex-specific mortality risk of hip fracture are greater than those of breast cancer (hazard ratio [HR]: 0.93, 95% confidence interval [CI]: 0.90 to 0.97) and thyroid cancer (HR: 0.55, 95% CI: 0.47 to 0.64) in females and prostate cancer (HR: 0.56, 95% CI: 0.53 to 0.58) in males. Moreover, mortality rates in lung cancer, male liver cancer, female breast cancer, and male prostate cancer have decreased in the past decade. For hip fracture, the mortality rates have significantly decreased in females, while in males, we observed only a decreasing trend in 1-year hip fracture mortality, not in 5-year</div></div><div><h3>Conclusions</h3><div>Hip fractures exhibit higher mortality compared to female breast and thyroid cancers and male prostate cancer. More attention is needed to enhance the management and prevention of hip fractures.</div></div>","PeriodicalId":19701,"journal":{"name":"Osteoporosis and Sarcopenia","volume":"11 1","pages":"Pages 15-21"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Osteoporosis and Sarcopenia

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀