Pub Date : 2022-02-03DOI: 10.55047/comorbid.v1i2.77
L. Kusumawati, E. Darmawan, Nurcholid Umam Kurniawan
This study aimed to examine the effectiveness of combining salbutamol nebulizer and procaterol oral compared to only procaterol oral on the respiratory status including temperature (fever), spasm, cough, retraction and length of stay (LOS), among young children with pneumonia. This prospective cohort study included 48 consecutive sampling subjects with pneumonia in Indonesia. The subjects were classified based on the type of therapy they received: intervention group used the combination of salbutamol nebulizer and procaterol oral therapy (n = 24) and the control group used procaterol oral only (n = 24). The study of the two groups showed that the combination salbutamol nebulizer and procaterol oral was more effective than the administration of procaterol oral only with the rate of clinical change. The significant effectiveness of nebulizer salbutamol and oral procaterol to reducing respiratory status (p=0.006) and temperature (fever) (p=0.000) compared to the only procaterol oral. However, there was no significant effectiveness of nebulizer salbutamol and oral procaterol in reducing spasm (p=0.348), cough (p=0.964), retraction (p=0.666) and length of stay (LOS) (p=0.192) compared to the only procaterol oral among the Indonesian children with pneumonia.
{"title":"THE COMBINATION OF SALBUTAMOL NEBULIZER AND PROCATEROL ORAL TO THE INDONESIAN CHILDREN WITH PNEUMONIA","authors":"L. Kusumawati, E. Darmawan, Nurcholid Umam Kurniawan","doi":"10.55047/comorbid.v1i2.77","DOIUrl":"https://doi.org/10.55047/comorbid.v1i2.77","url":null,"abstract":"\u0000This study aimed to examine the effectiveness of combining salbutamol nebulizer and procaterol oral compared to only procaterol oral on the respiratory status including temperature (fever), spasm, cough, retraction and length of stay (LOS), among young children with pneumonia. This prospective cohort study included 48 consecutive sampling subjects with pneumonia in Indonesia. The subjects were classified based on the type of therapy they received: intervention group used the combination of salbutamol nebulizer and procaterol oral therapy (n = 24) and the control group used procaterol oral only (n = 24). The study of the two groups showed that the combination salbutamol nebulizer and procaterol oral was more effective than the administration of procaterol oral only with the rate of clinical change. The significant effectiveness of nebulizer salbutamol and oral procaterol to reducing respiratory status (p=0.006) and temperature (fever) (p=0.000) compared to the only procaterol oral. However, there was no significant effectiveness of nebulizer salbutamol and oral procaterol in reducing spasm (p=0.348), cough (p=0.964), retraction (p=0.666) and length of stay (LOS) (p=0.192) compared to the only procaterol oral among the Indonesian children with pneumonia. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000","PeriodicalId":19772,"journal":{"name":"PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72739685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-01DOI: 10.55047/comorbid.v1i2.73
Dian Anggraeni, Riza Fikriana, Wiwit Nurbadriyah
Diabetes mellitus is a chronic disease of metabolic disorders and hyperglycemia caused by impaired insulin secretion which is characterized by an increase in blood glucose levels exceeding normal limits (70-140 mg/dL). Diabetes mellitus can be caused by several factors, one of which is a poor diet. The purpose of this study was to analyze the effect of attitudes, education level and support of health workers on the ability to manage dietary patterns in diabetes mellitus sufferers using the Self-Care theory approach in Banjarejo Village, Pakis District. The research design used Analytical Observational with Cross-Sectional method. The sample used is 80 respondents using Non Probability Sampling with purposive sampling technique. The variables used are attitude, level of education, support of health workers and ability to manage diet patterns. The process of collecting data using a questionnaire in accordance with the inclusion and exclusion criteria, then data processing is carried out and followed by a statistical test of logistic regression using the help of a computer program. The results of the Logistic Regression Test showed that the variable that had the most influence on the ability to manage dietary patterns was the support of health workers variable with a significance value (p-value) of 0,044 < 0,05. As a result, it can be seen that health worker support is one of the factors that can affect a person's ability to manage diet patterns, and thus that there is a need for positive health worker support for diabetes mellitus patients in order to increase their ability to manage diet patterns and avoid uncontrolled increases in blood sugar levels or complications.
{"title":"THE EFFECT OF ATTITUDE, LEVEL OF EDUCATION AND SUPPORT OF HEALTH PERSONNEL ON THE ABILITY OF REGULATING DIET PATTERNS IN DIABETES MELLITUS PATIENTS USING A SELF-CARE THEORY APPROACH","authors":"Dian Anggraeni, Riza Fikriana, Wiwit Nurbadriyah","doi":"10.55047/comorbid.v1i2.73","DOIUrl":"https://doi.org/10.55047/comorbid.v1i2.73","url":null,"abstract":"Diabetes mellitus is a chronic disease of metabolic disorders and hyperglycemia caused by impaired insulin secretion which is characterized by an increase in blood glucose levels exceeding normal limits (70-140 mg/dL). Diabetes mellitus can be caused by several factors, one of which is a poor diet. The purpose of this study was to analyze the effect of attitudes, education level and support of health workers on the ability to manage dietary patterns in diabetes mellitus sufferers using the Self-Care theory approach in Banjarejo Village, Pakis District. The research design used Analytical Observational with Cross-Sectional method. The sample used is 80 respondents using Non Probability Sampling with purposive sampling technique. The variables used are attitude, level of education, support of health workers and ability to manage diet patterns. The process of collecting data using a questionnaire in accordance with the inclusion and exclusion criteria, then data processing is carried out and followed by a statistical test of logistic regression using the help of a computer program. The results of the Logistic Regression Test showed that the variable that had the most influence on the ability to manage dietary patterns was the support of health workers variable with a significance value (p-value) of 0,044 < 0,05. As a result, it can be seen that health worker support is one of the factors that can affect a person's ability to manage diet patterns, and thus that there is a need for positive health worker support for diabetes mellitus patients in order to increase their ability to manage diet patterns and avoid uncontrolled increases in blood sugar levels or complications.","PeriodicalId":19772,"journal":{"name":"PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82153754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-29DOI: 10.55047/comorbid.v1i1.67
L. Hidayah, E. Darmawan, Santi Yuliani
The use of atypical antipsychotics often causes an increase in blood glucose levels, body mass index (BMI) and abdominal circumference. This study aims to identify the increased risk of random blood glucose, BMI and abdominal circumference in the schizophrenic patients using clozapine and quetiapine. This cohort study involved 35 schizophrenic patients (19 patients used clozapine and 16 patients used quetiapine). The measurement of random blood glucose BMI and abdominal circumference was done in the zero month, the first month and the second month. The average of random blood glucose, BMI and abdominal circumference were analyzed using Wilcoxon and Chi-square. In the use of clozapine, there is a significant increase in the average of random blood glucose between the first month and the second month (p=0.1) with the difference of 6.37 mg/dl, there is an increase average in BMI between the first month and the second month (p=0.03) with the difference of 0.18 kg/m² and an average increase in abdominal circumference between the zero month and the first month (p=0.04) with the difference of 1.47 cm, between the first month and the second month (p=0.02) with the difference of 1.94 cm. In the use of quetiapine, a significant increase in abdominal circumference between the first month and the second month (p=0.02) with the difference 1.38 cm. The use of clozapine has more risk in increasing random blood glucose (OR 2.00: CI 95% 0.41-9.76), BMI (OR 2.78: CI 95% 0.69-11.10) and abdominal circumference (OR 3.61: CI 95% 0.89-14.64) compared to the use of quetiapine. The use of clozapine has more risk in increasing blood glucose, BMI and abdominal circumference compared to the use of quetiapine.
非典型抗精神病药物的使用通常会导致血糖水平、身体质量指数(BMI)和腹围增加。本研究旨在确定使用氯氮平和喹硫平的精神分裂症患者随机血糖、BMI和腹围增加的风险。这项队列研究涉及35名精神分裂症患者(19名患者使用氯氮平，16名患者使用喹硫平)。随机测定血糖、BMI和腹围，分别于第0个月、第1个月和第2个月测定。随机血糖、BMI和腹围平均值采用Wilcoxon和卡方分析。使用氯氮平后第一个月与第二个月随机血糖平均值显著升高(p=0.1)，差值为6.37 mg/dl;第一个月与第二个月BMI平均值升高(p=0.03)，差值为0.18 kg/m²;第0个月与第一个月腹围平均值升高(p=0.04)，差值为1.47 cm;第1个月与第2个月比较(p=0.02)，差异为1.94 cm。在使用喹硫平时，第1个月和第2个月的腹围明显增加(p=0.02)，差异为1.38 cm。与使用喹硫平相比，氯氮平增加随机血糖(OR 2.00: CI 95% 0.41-9.76)、BMI (OR 2.78: CI 95% 0.69-11.10)和腹围(OR 3.61: CI 95% 0.89-14.64)的风险更高。与喹硫平相比，氯氮平增加血糖、BMI和腹围的风险更大。
{"title":"THE INCREASED RISK OF RANDOM BLOOD GLUCOSE, BODY MASS INDEX AND ABDOMINAL CIRCUMFERENCE IN THE SCHIZOPHRENIC PATIENTS USING CLOZAPINE AND QUETIAPINE","authors":"L. Hidayah, E. Darmawan, Santi Yuliani","doi":"10.55047/comorbid.v1i1.67","DOIUrl":"https://doi.org/10.55047/comorbid.v1i1.67","url":null,"abstract":"\u0000The use of atypical antipsychotics often causes an increase in blood glucose levels, body mass index (BMI) and abdominal circumference. This study aims to identify the increased risk of random blood glucose, BMI and abdominal circumference in the schizophrenic patients using clozapine and quetiapine. This cohort study involved 35 schizophrenic patients (19 patients used clozapine and 16 patients used quetiapine). The measurement of random blood glucose BMI and abdominal circumference was done in the zero month, the first month and the second month. The average of random blood glucose, BMI and abdominal circumference were analyzed using Wilcoxon and Chi-square. In the use of clozapine, there is a significant increase in the average of random blood glucose between the first month and the second month (p=0.1) with the difference of 6.37 mg/dl, there is an increase average in BMI between the first month and the second month (p=0.03) with the difference of 0.18 kg/m² and an average increase in abdominal circumference between the zero month and the first month (p=0.04) with the difference of 1.47 cm, between the first month and the second month (p=0.02) with the difference of 1.94 cm. In the use of quetiapine, a significant increase in abdominal circumference between the first month and the second month (p=0.02) with the difference 1.38 cm. The use of clozapine has more risk in increasing random blood glucose (OR 2.00: CI 95% 0.41-9.76), BMI (OR 2.78: CI 95% 0.69-11.10) and abdominal circumference (OR 3.61: CI 95% 0.89-14.64) compared to the use of quetiapine. The use of clozapine has more risk in increasing blood glucose, BMI and abdominal circumference compared to the use of quetiapine. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000","PeriodicalId":19772,"journal":{"name":"PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83320860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-20DOI: 10.55047/comorbid.v1i1.56
Nur Astuti Wulandari, E. Darmawan, Nurcholid Umam Kurniawan
Pneumonia is an infectious disease that occurs in the lungs caused by various microorganisms. Patients of children with pneumonia in Indonesia experienced an increase in 2013. Antibiotics therapy is the main therapy for patients with pneumonia. This study aims to compare of the efficacy of ceftriaxone and combination of ampicillin-chloramphenicol of children with pneumonia of PKU Muhammadiyah hospital in Bantul. The study design was a randomized controlled trial with prospective Open trial do in March 2018 to June 2018. The outcomes used were tightness, cough, retraction, temperature, respiration rate, and length of stay. Research data were analyzed using Chi Square test, Fisher test, independent t test and Mann Whitney test. The results of the study of ceftriaxone (n=26) and ampicillin chloramphenicol groups (n=26) showed that the percentage of patients who had not experienced tightness was 82.7%, not cough 7.7%, and there was no retraction of 76.9% with p<0.05. The mean ±SD temperature of the ceftriaxone group was 36.5±0.12 and the ampicillin chloramphenicol group was 36.57±0.09 with a p<0.05. The mea n±SD respiration rate of the ceftriaxone group was 27.9±3.22 and the ampicillin chloramphenicol group was 27.92±2.62 with a p <0.05. The mean ±SD length of stay in the ceftriaxone group was 4.5±0.81 and the ampicillin chloramphenicol group was 4.26±0.66 with a p<0.05. Conclusions showed that there was no significant difference between the effectiveness of ceftriaxone and ampicillin chloramphenicol on fever, spasms, cough, retraction, temperature, respiration rate and length of stay.
{"title":"THE COMPARISON OF THE EFFICACY OF CEFTRIAXONE AND COMBINATION OF AMPICILLIN-CHLORAMPHENICOL OF CHILDREN WITH PNEUMONIA OF PKU MUHAMMADIYAH HOSPITAL IN BANTUL","authors":"Nur Astuti Wulandari, E. Darmawan, Nurcholid Umam Kurniawan","doi":"10.55047/comorbid.v1i1.56","DOIUrl":"https://doi.org/10.55047/comorbid.v1i1.56","url":null,"abstract":"\u0000Pneumonia is an infectious disease that occurs in the lungs caused by various microorganisms. Patients of children with pneumonia in Indonesia experienced an increase in 2013. Antibiotics therapy is the main therapy for patients with pneumonia. This study aims to compare of the efficacy of ceftriaxone and combination of ampicillin-chloramphenicol of children with pneumonia of PKU Muhammadiyah hospital in Bantul. The study design was a randomized controlled trial with prospective Open trial do in March 2018 to June 2018. The outcomes used were tightness, cough, retraction, temperature, respiration rate, and length of stay. Research data were analyzed using Chi Square test, Fisher test, independent t test and Mann Whitney test. The results of the study of ceftriaxone (n=26) and ampicillin chloramphenicol groups (n=26) showed that the percentage of patients who had not experienced tightness was 82.7%, not cough 7.7%, and there was no retraction of 76.9% with p<0.05. The mean ±SD temperature of the ceftriaxone group was 36.5±0.12 and the ampicillin chloramphenicol group was 36.57±0.09 with a p<0.05. The mea n±SD respiration rate of the ceftriaxone group was 27.9±3.22 and the ampicillin chloramphenicol group was 27.92±2.62 with a p <0.05. The mean ±SD length of stay in the ceftriaxone group was 4.5±0.81 and the ampicillin chloramphenicol group was 4.26±0.66 with a p<0.05. Conclusions showed that there was no significant difference between the effectiveness of ceftriaxone and ampicillin chloramphenicol on fever, spasms, cough, retraction, temperature, respiration rate and length of stay. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000","PeriodicalId":19772,"journal":{"name":"PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89111870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-20DOI: 10.55047/comorbid.v1i1.66
Fadhila Diah Suminar
Infection is one of the biggest causes of death in Indonesia which can be influenced by the appropriate use of antibiotics. Irrational use of antibiotics can cause bacteria to become resistant to antibiotics so that the effectiveness of the drug decreases or even disappears. This study aims to evaluate the use of antibiotics given to inpatients at a private hospital in Indonesia both quantitatively and qualitatively in the period July to December 2021. This study is an observational study with retrospective data collection where qualitative analysis using the Gyssens Method and quantitative analysis uses the DDD method. The results of the qualitative analysis showed that from 30 cases observed, there were 9 cases (30%) irrational prescriptions, namely 1 case in category V, 4 cases in category IVA, 2 cases in category IIIB and 2 cases in category IIA. The results of the quantitative analysis showed that the antibiotics with the highest DDD/100 patient days in the period July to December 2021 were Ceftriaxone with a successive value of 39.15; 39.81; 36.22; 55.65; 41,48 and 49, 42 while antibiotics with the lowest DDD/100 patient-days values in the period July to December obtained different results. Based on research results, there are irrational antibiotic prescriptions and Ceftriaxone became the most commonly prescribed antibiotic.
{"title":"RATIONALITY OF ANTIBIOTICS USE WITH QUANTITATIVE AND QUALITATIVE METHODS AT HOSPITAL IN INDONESIA","authors":"Fadhila Diah Suminar","doi":"10.55047/comorbid.v1i1.66","DOIUrl":"https://doi.org/10.55047/comorbid.v1i1.66","url":null,"abstract":"\u0000Infection is one of the biggest causes of death in Indonesia which can be influenced by the appropriate use of antibiotics. Irrational use of antibiotics can cause bacteria to become resistant to antibiotics so that the effectiveness of the drug decreases or even disappears. This study aims to evaluate the use of antibiotics given to inpatients at a private hospital in Indonesia both quantitatively and qualitatively in the period July to December 2021. This study is an observational study with retrospective data collection where qualitative analysis using the Gyssens Method and quantitative analysis uses the DDD method. The results of the qualitative analysis showed that from 30 cases observed, there were 9 cases (30%) irrational prescriptions, namely 1 case in category V, 4 cases in category IVA, 2 cases in category IIIB and 2 cases in category IIA. The results of the quantitative analysis showed that the antibiotics with the highest DDD/100 patient days in the period July to December 2021 were Ceftriaxone with a successive value of 39.15; 39.81; 36.22; 55.65; 41,48 and 49, 42 while antibiotics with the lowest DDD/100 patient-days values in the period July to December obtained different results. Based on research results, there are irrational antibiotic prescriptions and Ceftriaxone became the most commonly prescribed antibiotic. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000","PeriodicalId":19772,"journal":{"name":"PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80141870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-20DOI: 10.55047/comorbid.v1i1.55
Tri Yanuarto, Nurkhasanah, Laela Hayu Nurani
The reactivity of oxidant compounds that exceed the limits of antioxidant protection ability can cause chain reactions which cause interference with the system. Prevention is needed to neutralize the oxidants, so that exogenous antioxidants are needed. One example is the jamblang fruit (Syzygium cumini (L)) which has high antioxidant activity due to its natural anthocyanin. The purpose of this study was to determine the optimal form of yogurt with the addition of jamblang fruit extract with a concentration of 0%, 5%, 7.5% and 10% and the quality of SNI. Tests carried out include physical, chemical and microbiological tests, namely sensory, acid content, total protein, fat content, and a number of bacterial starters, as well as safety tests with storage at 4° C then 0, to 7, 14th, 21st and 28th day. Data analysis using MANOVA. The results of the effect of the product showed that the fruit of yogurt with 10% extract level provided good stability during storage. Decreased antioxidant levels on day 7 to day 28. Antioxidant activity is more stable than antioxidant jamblang fruit extract. The antioxidant activity of yogurt with 5% jamblang fruit extract; 7.5% and 10% on day 0% % inhibition value of 57.48%; 62.06%; and 73.01%.
{"title":"OPTIMIZATION OF JAMBLANG (Syzygium Cumini (L.) Skeels) FRUIT EXTRACT LEVELS IN YOGHURT FORMULATION AS ANTIOXIDANT","authors":"Tri Yanuarto, Nurkhasanah, Laela Hayu Nurani","doi":"10.55047/comorbid.v1i1.55","DOIUrl":"https://doi.org/10.55047/comorbid.v1i1.55","url":null,"abstract":"\u0000The reactivity of oxidant compounds that exceed the limits of antioxidant protection ability can cause chain reactions which cause interference with the system. Prevention is needed to neutralize the oxidants, so that exogenous antioxidants are needed. One example is the jamblang fruit (Syzygium cumini (L)) which has high antioxidant activity due to its natural anthocyanin. The purpose of this study was to determine the optimal form of yogurt with the addition of jamblang fruit extract with a concentration of 0%, 5%, 7.5% and 10% and the quality of SNI. Tests carried out include physical, chemical and microbiological tests, namely sensory, acid content, total protein, fat content, and a number of bacterial starters, as well as safety tests with storage at 4° C then 0, to 7, 14th, 21st and 28th day. Data analysis using MANOVA. The results of the effect of the product showed that the fruit of yogurt with 10% extract level provided good stability during storage. Decreased antioxidant levels on day 7 to day 28. Antioxidant activity is more stable than antioxidant jamblang fruit extract. The antioxidant activity of yogurt with 5% jamblang fruit extract; 7.5% and 10% on day 0% % inhibition value of 57.48%; 62.06%; and 73.01%. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000","PeriodicalId":19772,"journal":{"name":"PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89759394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-20DOI: 10.55047/comorbid.v1i1.64
Amalia Agamasi, E. Darmawan, Akrom
There are 126,675 DHF sufferers in 34 provinces and 1,229 of them died, while the Incidence Rate (IR) in Central Java is 47.9 per 100,000 population. Based on the safety of Psidium guajava Linn on the liver by calculating the lethal dose average showed that there were no deaths from the two experimental models of Swiss mice and Wistar mice in the dose range up to 2,000 mg/kg BB. Safety tests in rats proved lethal dose 50 (LD50) of guava leaf extract more than 5 g/kg. This study aims to determine the effect of psidii capsules containing guava leaf extract (Psidium guajava Linn.) toward levels (SGOT and SGPT) of DF and DHF patients in PKU Muhammadiyah Wonosobo Hospital. This study belongs to perspective cohort analytic observational using blood plasma patients of PKU Muhammadiyah Wonosobo Hospital of 37 patients in the period of March to August 2018 which were divided into two groups, namely standard therapy + guava leaf extract capsules and the group receiving standard therapy only. Dosage of Psidium guajava 3x2 capsules for 3 to 4 days. Examination of SGOT and SGPT levels used UV-vis spectrophotometry. General linear model was used for analyzing the data. The average SGOT level after treatment was 64 U/L in DF and 99 at DHF while the SGPT levels were 30 U/L and 35 U/L. Average levels of SGOT and SGPT decreased. There were no differences in SGOT and SGPT mean of DF and DHF patients in the two groups after giving guava leaf extract capsules with p>0.05. In SGOT mean, there was an increase in SGOT after giving guava leaf extract probably because there were patients who had chronic liver disorders. Keywords: Dengue Fever, Dengue Hemorrhagic Fever, Guava extract capsule, SGOT SGPT
{"title":"EVALUATION OF THE SECURITY OF THE USE OF GUAJAVA PSIDIUM EXTRACT CAPSULE ON HEART FUNCTION IN DENGUE FEVER AND DENGUE HEMORAGIC FEVER PATIENTS IN TYPE C HOSPITAL","authors":"Amalia Agamasi, E. Darmawan, Akrom","doi":"10.55047/comorbid.v1i1.64","DOIUrl":"https://doi.org/10.55047/comorbid.v1i1.64","url":null,"abstract":"\u0000There are 126,675 DHF sufferers in 34 provinces and 1,229 of them died, while the Incidence Rate (IR) in Central Java is 47.9 per 100,000 population. Based on the safety of Psidium guajava Linn on the liver by calculating the lethal dose average showed that there were no deaths from the two experimental models of Swiss mice and Wistar mice in the dose range up to 2,000 mg/kg BB. Safety tests in rats proved lethal dose 50 (LD50) of guava leaf extract more than 5 g/kg. This study aims to determine the effect of psidii capsules containing guava leaf extract (Psidium guajava Linn.) toward levels (SGOT and SGPT) of DF and DHF patients in PKU Muhammadiyah Wonosobo Hospital. This study belongs to perspective cohort analytic observational using blood plasma patients of PKU Muhammadiyah Wonosobo Hospital of 37 patients in the period of March to August 2018 which were divided into two groups, namely standard therapy + guava leaf extract capsules and the group receiving standard therapy only. Dosage of Psidium guajava 3x2 capsules for 3 to 4 days. Examination of SGOT and SGPT levels used UV-vis spectrophotometry. General linear model was used for analyzing the data. The average SGOT level after treatment was 64 U/L in DF and 99 at DHF while the SGPT levels were 30 U/L and 35 U/L. Average levels of SGOT and SGPT decreased. There were no differences in SGOT and SGPT mean of DF and DHF patients in the two groups after giving guava leaf extract capsules with p>0.05. In SGOT mean, there was an increase in SGOT after giving guava leaf extract probably because there were patients who had chronic liver disorders. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000Keywords: Dengue Fever, Dengue Hemorrhagic Fever, Guava extract capsule, SGOT SGPT \u0000","PeriodicalId":19772,"journal":{"name":"PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81866264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-10DOI: 10.55047/comorbid.v1i1.33
Arsana Wiyasa, Muhamad Nofa Cholili
Miscarriage occurs when the fetus is unable to survive outside the womb and the results of conception are expelled. Although the issue of RPL is still controversial, current information about the suggested treatment offers effective treatment to improve reproductive quality and can provide appropriate therapy in a woman with RPL based on the etiology. The time restriction until the fetus is pronounced viable or capable of surviving outside the womb varies by country. According to the World Health Organization, over 21.6 million abortions occurred worldwide in 2008, with almost all of these cases occur in developing countries. The risk of miscarriage increases most significantly at the age of 35 years. Women aged 35 years have twice the risk of miscarriage compared to women aged < 35 years. Antiphospholipid syndrome is a risk factor for recurrent miscarriage, which occurs in about 15% of patients. The reason of recurrent miscarriage can be linked to both fetal and maternal factors. Diagnostic examinations are not recommended in patients with recurrent miscarriage unless certain criteria are met. However, screening can be used to identify risk factors. The management of recurrent miscarriage should be addressed toward the underlying cause with a treatable etiology or pathophysiology.
{"title":"THE MANAGEMENT OF RECURRENT MISCARRIAGE TOWARD THE UNDERLYING CAUSE WITH A TREATABLE ETIOLOGY OR PATHOPHYSIOLOGY","authors":"Arsana Wiyasa, Muhamad Nofa Cholili","doi":"10.55047/comorbid.v1i1.33","DOIUrl":"https://doi.org/10.55047/comorbid.v1i1.33","url":null,"abstract":"\u0000Miscarriage occurs when the fetus is unable to survive outside the womb and the results of conception are expelled. Although the issue of RPL is still controversial, current information about the suggested treatment offers effective treatment to improve reproductive quality and can provide appropriate therapy in a woman with RPL based on the etiology. The time restriction until the fetus is pronounced viable or capable of surviving outside the womb varies by country. According to the World Health Organization, over 21.6 million abortions occurred worldwide in 2008, with almost all of these cases occur in developing countries. The risk of miscarriage increases most significantly at the age of 35 years. Women aged 35 years have twice the risk of miscarriage compared to women aged < 35 years. Antiphospholipid syndrome is a risk factor for recurrent miscarriage, which occurs in about 15% of patients. The reason of recurrent miscarriage can be linked to both fetal and maternal factors. Diagnostic examinations are not recommended in patients with recurrent miscarriage unless certain criteria are met. However, screening can be used to identify risk factors. The management of recurrent miscarriage should be addressed toward the underlying cause with a treatable etiology or pathophysiology. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000","PeriodicalId":19772,"journal":{"name":"PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79780828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-10DOI: 10.55047/comorbid.v1i1.36
Adhitya Riski Apriady, Yusuf Wibisono, Asep Nugraha Hermawan
Intracranial tumors are rare in headache sufferers, although headache is common in intracranial tumor patients. This limits the utility of headache symptoms to make a diagnosis, and it's crucial to know whether people with intracranial tumors have specific headache criteria. Other investigations do not support the classic criteria for headache in intracranial tumors, such as progressive, worse in the morning, and exacerbated by Valsalva maneuvers. Clinical studies found that headache as the sole symptom was rare, and only occurred in 2% of patients, hence this study also investigated the prevalence of nausea/vomiting, seizures, loss of consciousness, and motor deficits. This study uses resumes of medical records of patients diagnosed with intracranial tumors and hospitalized in the Department of Neurology, dr. Hasan Sadikin Central General Hospital West Java, Indonesia. While the sampling method in this study was total sampling, by taking all medical record resumes of patients with intracranial tumors from January to December 2018. Headache was a prevalent symptom of intracranial tumors in this study, occurring in 75,3 % of the subjects and was usually accompanied by other symptoms, especially motor deficits (64,5%), loss of consciousness (60,2%), nausea and vomiting (31) 2%), and seizures (23,7%). Patients were most likely to have bilateral headaches (62,5%), and 63,6% of patients who had unilateral headaches had a unilateral intracranial tumor on the same side of the headache. Patients who experienced progressive headaches were 93,5% of patients. While, the most common headache onset in patients with intracranial tumors before hospital admission were; 3-30 days (40,4%) and > 30 days - 6 months (38,5%).
{"title":"HEADACHE PROFILE AND ASSOCIATED SYMPTOMS IN INTRACRANIAL TUMORS","authors":"Adhitya Riski Apriady, Yusuf Wibisono, Asep Nugraha Hermawan","doi":"10.55047/comorbid.v1i1.36","DOIUrl":"https://doi.org/10.55047/comorbid.v1i1.36","url":null,"abstract":"\u0000Intracranial tumors are rare in headache sufferers, although headache is common in intracranial tumor patients. This limits the utility of headache symptoms to make a diagnosis, and it's crucial to know whether people with intracranial tumors have specific headache criteria. Other investigations do not support the classic criteria for headache in intracranial tumors, such as progressive, worse in the morning, and exacerbated by Valsalva maneuvers. Clinical studies found that headache as the sole symptom was rare, and only occurred in 2% of patients, hence this study also investigated the prevalence of nausea/vomiting, seizures, loss of consciousness, and motor deficits. This study uses resumes of medical records of patients diagnosed with intracranial tumors and hospitalized in the Department of Neurology, dr. Hasan Sadikin Central General Hospital West Java, Indonesia. While the sampling method in this study was total sampling, by taking all medical record resumes of patients with intracranial tumors from January to December 2018. Headache was a prevalent symptom of intracranial tumors in this study, occurring in 75,3 % of the subjects and was usually accompanied by other symptoms, especially motor deficits (64,5%), loss of consciousness (60,2%), nausea and vomiting (31) 2%), and seizures (23,7%). Patients were most likely to have bilateral headaches (62,5%), and 63,6% of patients who had unilateral headaches had a unilateral intracranial tumor on the same side of the headache. Patients who experienced progressive headaches were 93,5% of patients. While, the most common headache onset in patients with intracranial tumors before hospital admission were; 3-30 days (40,4%) and > 30 days - 6 months (38,5%). \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000","PeriodicalId":19772,"journal":{"name":"PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90722553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-10DOI: 10.55047/comorbid.v1i1.38
Muhammad Taupik, Endah Nurrohwinta Djuwarno, M.Sc Mohammad Adam Mustapa, Muhamad Handoyo Sahumena
In the last twenty years, many of jamu or herbal medicine were adulterated with chemical drugs. One of the chemical drugs that is commonly added to herbal medicine is acetaminophen. Acetaminophen is generally considered as an analgesic-antipyretic drug. The sample of this study consisted of 6 samples of jamu or herbal medicine with different brands. Qualitative analysis was conducted by TLC method using the mobile phase n-hexane: ethyl acetate (1:1), it was obtained three positive samples containing acetaminophen, namely sample D, E, and F. The three positive samples containing acetaminophen were calculated using the LCMS method. Quantitative analysis was conducted with LCMS using a reversed-phase with a mobile phase of acetonitrile: water (15%>: 85%> v/v) at a flow rate of 0.2 mL/min and an injection volume of 5 gL, it was obtained the levels of acetaminophen in sample D as much as 0.16 g/2 g of sample, in sample E of 0.63 g/7 g of sample, and in sample F of 0.56 g/7 g of sample. Although the content of acetaminophen in herbal medicine is relatively small, but according to the Regulation of the Minister of Health of Indonesia No. 007 of 2012, traditional medicine or herbal medicine should not contain synthetic chemicals.
{"title":"THE IDENTIFICATION AND STUDY OF HERBAL MEDICINE (JAMU) FRAGMENTATION PATTERNS CONFIRMED ACETAMINOPHEN BY USING LIQUID CHROMATOGRAPHY MASS SPECTROSCOPY (LCMS)","authors":"Muhammad Taupik, Endah Nurrohwinta Djuwarno, M.Sc Mohammad Adam Mustapa, Muhamad Handoyo Sahumena","doi":"10.55047/comorbid.v1i1.38","DOIUrl":"https://doi.org/10.55047/comorbid.v1i1.38","url":null,"abstract":"\u0000In the last twenty years, many of jamu or herbal medicine were adulterated with chemical drugs. One of the chemical drugs that is commonly added to herbal medicine is acetaminophen. Acetaminophen is generally considered as an analgesic-antipyretic drug. The sample of this study consisted of 6 samples of jamu or herbal medicine with different brands. Qualitative analysis was conducted by TLC method using the mobile phase n-hexane: ethyl acetate (1:1), it was obtained three positive samples containing acetaminophen, namely sample D, E, and F. The three positive samples containing acetaminophen were calculated using the LCMS method. Quantitative analysis was conducted with LCMS using a reversed-phase with a mobile phase of acetonitrile: water (15%>: 85%> v/v) at a flow rate of 0.2 mL/min and an injection volume of 5 gL, it was obtained the levels of acetaminophen in sample D as much as 0.16 g/2 g of sample, in sample E of 0.63 g/7 g of sample, and in sample F of 0.56 g/7 g of sample. Although the content of acetaminophen in herbal medicine is relatively small, but according to the Regulation of the Minister of Health of Indonesia No. 007 of 2012, traditional medicine or herbal medicine should not contain synthetic chemicals. \u0000","PeriodicalId":19772,"journal":{"name":"PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83663148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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