Pamukkale Medical Journal最新文献

{"title":"The relationship between sexual behavior and well-being during the COVID-19 pandemic: an online survey study","authors":"Z. Sofuoğlu, C. Baysan, H. Gülmez, S. Palanbek Yavaş, P. Ayvat","doi":"10.31362/patd.1216204","DOIUrl":"https://doi.org/10.31362/patd.1216204","url":null,"abstract":"Purpose: In addition to its psychologically and socially negative effects on society, the COVID-19 pandemic has affected the sexual behavior of individuals. This study investigated the relationship between changes in sexual drive and well-being during the COVID-19 pandemic period. \u0000Materials and methods: The data of this cross-sectional study were collected using a web-based survey between 12 May and August 12, 2021, with the voluntary participation of 231 individuals. The survey form included questions on sociodemographic and health-related characteristics, employment status, sex life before and in the COVID-19 pandemic period and status of having a partner, and COVID-19 diagnostic status, in addition to the Short Warwick-Edinburgh Mental Well-Being Scale. \u0000Results: A reduction in sexual drive in the pandemic period was reported by 71 (30.7%) of the participants. The group whose sexual drive decreased had significant differences in terms of age, marital status, the status of having children, and Warwick-Edinburgh scale scores compared to the groups whose sexual drive increased or remained unchanged (respectively, p=0.009, p=0.039, p=0.041, and p","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85033839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of tuberculosis in children using biological agent therapy","authors":"Y. Kara, M. C. Kizil, Merve İşeri Nepesov, Aslı Kavaz Tufan, N. Çetin, Y. Aydemir, Z. Barış, Hilal Kaya Erdoğan, Ömer Kılıç, E. Dinleyici","doi":"10.31362/patd.1189676","DOIUrl":"https://doi.org/10.31362/patd.1189676","url":null,"abstract":"Purpose: Anti-TNF drugs increase the risk of tuberculosis. In this study we aimed to investigate the incidence of tuberculosis in patients using anti-TNF drugs.Methods: One hundred and fifteen pediatric cases which were received anti-TNF drugs were included in the study. The clinical and epidemiological characteristics of the cases were analyzed retrospectively.Results: One hundred and fifteen cases using anti-TNF drugs were included in the study. The diagnoses of the cases were as follows; Juvenile Rheumatoid Arthritis 76 (66%), Ulcerative Colitis 11 (9.6%), Crohn's 7 (6%), Ankylosing Spondylitis 6 (5.2%), FMF 5 (4.3%), Psoriasis 4 (%3.5). The distribution of the agents used by the patients was; etanercept 74 (64.3%), infliximab 17 (14.8%), adalimumab 17 (14.8%), anakinra 5 (4.3%), and canakinumab 2 (%1.7). It was learned that all cases had BCG vaccinations when they were two months old, confirmed by the vaccination cards and the ministry of health's vaccination follow-up system. TST was performed in all of the cases and TST response was measured as <5mm in 89 (77.4%), 5-9 mm in 11 (8.7%), 10-14 mm in 8 (7.4%), >15 mm in 7 (5.6%) cases. Isoniazid (INH) prophylaxis was started for nine months in 17 cases with the diagnosis of latent tuberculosis. Active tuberculosis was not detected in any of the cases.Conclusion: All patients receiving anti-TNF need to be evaluated for tuberculosis. Although it is not detected at the beginning of the treatment, regular tuberculosis screening should be continued during the treatment with contact history, symptoms, physical examination, chest X-ray, and TST/IGRA in light of current guidelines.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82083709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sağlık çalışanlarında kanserden korunma ve erken tarama yöntemleri ile ilgili bilgi düzeylerinin değerlendirilmesi","authors":"Halil Sağınç, Burcu YAPAR TAŞKÖYLÜ","doi":"10.31362/patd.1170681","DOIUrl":"https://doi.org/10.31362/patd.1170681","url":null,"abstract":"Amaç: Kanserden korunma ve erken tarama programlarının farkındalığını arttırmak için sağlık çalışanlarına planlı eğitiminin etkisini araştırmaktır. Gereç ve Yöntem: Kanser erken tanı eğitimimizde kanserden korunma ve erken tarama programlarının bilinirliği üzerine 60 sağlık çalışanına 15 soru ile anket uygulandı. Eğitime katılan 3 erkek, 57 kadın sağlık çalışanı çalışmaya alındı. Wilcoxon işaretli sıralar testi ve Mann-Whitney U testi kullanarak eğitimin sağlık çalışanları üzerindeki etkisi araştırıldı. Bulgular: 60 hemşire ve sağlık çalışanına uygulanan 15 soruluk anket yanıtlandığında Wilcoxon işaretli sıralar testi ön test doğru yanıt median 12 iken son test median doğru yanıt median 13 istatistiksel olarak anlamlı bulundu (p=0,00). Kadınlarda ön testte median doğru 12, erkeklerde ön testte median 8' dir (p=0,02). Erkekler ile kadınlar arasında ön testte belirgin kadınlar lehine doğru sayısı fazlaydı. Kadınlarda son testmedian yanıt 13, erkeklerde son testte median yanıt 11'dir (p=0,13). Yaş, eğitim durumu, hemşire ve diğer sağlık çalışanlarına göre anket ön test ve son testler arasında istatistiksel anlamlılık bulunmadı. Sonuç: Hastenede çalışan sağlık çalışanlarında kanser erken tanı yöntemleri, korunma yöntemleri ile ilgili bilgilendirme ile bilgi düzeylerinin istatistiksel anlamlı olarak arttığı görülmüştür. Erkek sağlık çalışanlarında kanser bilgilendirme eğitimi ile bilgi düzeylerinin daha fazla arttığı görüldü. Kolorektal kanserinde fekal immünokimyasal test (FITs), akciğer kanserinde düşük doz toraks BT (LDCT) ile tarama ve otofloresan görüntüleme bronkoskopisi (AFI), dar bant görüntüleme bronkoskopisi (NBI) gibi yeni tetkiklerin kullanılması erken evrede kanser tanısının konulmasını arttırır.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77690794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of nutritional habits and affecting factors of health care professionals during the Covid-19 pandemic stage: on-line survey study","authors":"I. Coşkun, E. Çanakçı, Z. Cebeci","doi":"10.31362/patd.1217576","DOIUrl":"https://doi.org/10.31362/patd.1217576","url":null,"abstract":"ABSTRACT \u0000Purpose: Health workers have been greatly affected by the pandemic, both as a health worker and as a member of the society, and have gone out of their routine lifestyle and habits more than normal individuals. In the pandemic stage; intense, irregular and stressful work pace also disrupted the routine eating habits while increasing the need for nutrition. With this survey study, it is aimed to evaluate the nutritional habits, affecting factors and results of healthcare professionals during the Covid-19 pandemic stage. \u0000 \u0000Materials and methods: For our study a questionnaire of 49 questions was prepared. It was continued between 01/06/2020 and 01/01/2021. Questionnaires were prepared on Google forms and sent to healthcare professionals via e-mail. Multiple-choice questions were asked about personal information such as the number of meals, whether they gained weight during the pandemic stage, foods believed to protect from Covid-19, nutritional supplements used during the pandemic period, and the reason for using supplements. The questions in the second category are; it mostly includes questions about changes in dietary and lifestyle of health workers during the pandemic period. It includes questions such as: ‘‘My meal count has increased’’, ‘‘My water consumption has increased’’, ‘‘My night eating behavior has improved’’, ‘‘My sleep pattern has been disrupted’’, ‘‘I gained weight during the pandemic’’, ‘‘I smoke more’’, ‘‘I drink more tea and coffee’’, ‘‘I try to exercise’’. The answers were obtained with a 3-point Likert scale (agree, undecided, disagree). \u0000 \u0000Results: It was determined that health workers experienced weight gain during the pandemic stage. It was determined that the average weight and average BMI of health professionals showed a statistically significant increase (p","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"632 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90886147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"snoRNAs are Deregulated in Patients with Parkinson’s Disease","authors":"P. Tokgün, A. Tomatır, Fatma Gizem Sarıekiz, Sinan Bi̇r","doi":"10.31362/patd.1218005","DOIUrl":"https://doi.org/10.31362/patd.1218005","url":null,"abstract":"Purpose: Small nucleolar RNAs are ranging from 65 to 300 nucleotides in length that mediate post-transcriptional RNA modifications. They don’t have a 5′-Cap and a poly-A tail and are categorized as C/D box snoRNAs, H/ACA box snoRNAs, and small Cajal body-specific RNAs. snoRNAs have essential roles in important biological processes such as transcription, RNA splicing, cell cycle, and etc. In this study, we tried to reveal differential expressions of snoRNAs in PBMCs of patients with Parkinson’s Disease by microarray analysis. \u0000Materials and methods: Patients (n=3) who are considered to have a unilateral onset history and a good response to dopaminergic treatment in the first years were included in the study. 10 ml peripheral blood sample was taken for peripheral blood mononuclear cell isolation. Total RNA was extracted using GeneAll® Hybrid-R™ kit and microarray analysis was performed by using Affymetrix GeneChip Human ST 2.0 platform. Raw data were extracted using Affymetrix Command Console Software 1.1. KEGG pathway and GO terms analyses were performed and protein-protein interaction of host genes were determined by using STRING database. \u0000Results: Data from patients revealed that there were 28 snoRNAs were downregulated and 3 snoRNAs were upregulated. \u0000Conclusion: Here in this study, we evaluated the differential expressions of snoRNAs in patients with a definitive diagnosis of PD by microarray analysis and observed deregulated expressions of some snoRNAs. Differential expression of snoRNA may cause changes in the transcriptional activity of host genes and thus can serve as biomarkers for diseases.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78077703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of rheumatic diseases in patients with familial Mediterranean fever","authors":"Gülçin Otar Yener, Selcuk Yuksel, Z. Ekici Tekin, Hülya Türkmen","doi":"10.31362/patd.1213710","DOIUrl":"https://doi.org/10.31362/patd.1213710","url":null,"abstract":"Purpose: Mutations in the Mediterranean FeVer (MEFV) gene, which causes familial Mediterranean fever (FMF), may also cause the emergence of other specific rheumatic diseases. This study aims to determine the frequency of other rheumatologic diseases in paediatric FMF patients, evaluate whether there are clinical and genetic differences between those with and without concomitant rheumatologic diseases, and compare the data with previous studies. \u0000Materials and methods: The files of FMF patients who were followed up at the paediatric rheumatology department were reviewed retrospectively. Demographic data, MEFV mutations, treatment, disease severity scores, and concomitant rheumatic diseases were recorded from the files. \u0000Results: There were 303 FMF patients (154 female/149 male). The mean age at diagnosis was 7.04±3.9 years. The mean disease duration was 5.33±3.13 years. In the cohort, 41 FMF patients (13.5%) were diagnosed with another rheumatic disease. There were 22 cases of juvenile idiopathic arthritis (53.6%), seven cases of vasculitis (17%), six cases of periodic fever aphthous stomatitis and adenitis syndrome (14.6%), three cases of Behçet disease (7.3%), two cases of acute rheumatic fever (4.8%), and one case of systemic lupus erythematosus (2.4%). 32 of these 41 FMF patients (78%) had the M694V mutation (homozygous in 11, heterozygous in 21). Disease activity scores PRAS and ISSF scores were higher in FMF with rheumatic diseases (p=0.002 and p","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75785222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of post-traumatic growth and traumatic and psychological effects in children and adolescents diagnosed with cancer","authors":"Merve Aktaş Terzioğlu, Tugce SOYLEİCİ MERT, S. Yakarisik, H. Şenol","doi":"10.31362/patd.1210932","DOIUrl":"https://doi.org/10.31362/patd.1210932","url":null,"abstract":"Purpose: The aim of this study was to evaluate and compare traumatic and mental effects and PTG by comparing a patient group in hematological-oncological cancer remission with a healthy control group. \u0000Materials and methods: Children and adolescents aged 8-18 years, who were in remission with a diagnosis of childhood cancer, and presented at the Paediatric Hematology Department of PAUTF between 1 September 2021 and 30 April 2022 were included as the study group and a control group was formed of healthy children and adolescents with no history of cancer diagnosis. The Post-traumatic Growth Inventory (PTGI), the Child Revised Impact of Events Scale (CRIES-13) and the Revised Child Anxiety and Depression Scale-Child Version (RCADS-CV) were applied to all the children in both groups. A sociodemographic information form prepared by the researchers, and the Revised Child Anxiety and Depression Scale- Parent Version (RCADS-PV) were applied to parents. \u0000Results: Evaluation was made of 27 patients aged 8-18 years with a diagnosis of childhood cancer who were in remission, and a control group of 25 healthy children. No statistically significant difference was determined between the groups in respect of parental ages, family structure, parental educational levels, and mean monthly family income (p>0.05).In the comparisons of the raw scores of the RCADS-PV between the two groups, RCADS-PV Panic Disorder, Obsessive Compulsive Disorder, and Depression subscale scores were found to be statistically significantly higher in the control group than in the remission group (p=0.048; p=0.045; p=0.047). When the CRIES-13 scores of the two groups were compared, no statistically significant difference was found (p=0.659).When the PTGI scales and subscales of the two groups were compared; while no statistically significant difference was found in the total PTGI score (p=0.066), the change in life philosophy subscale and the change in relationships with others subscale was found to be statistically significantly higher in the remission group than in the control group (p=0.038; p=0.05).Considering the relationship between CRIES-13 and PTGI scale scores, no statistically significant relationship was found in the remission group. \u0000Conclusion: Cancer survivors grow from this negative experience, become stronger and survive with positive gains; they can adjust their expectations from themselves, the world and their future. Considering the current prevalence of cancer and increasing survival rates with treatments, new multicenter studies with larger samples are needed on this subject.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86013532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Dynamic Contrast Magnetic Resonance Imaging (DCE-MRI) in the Diagnosis of Breast Cancer Cases","authors":"Arkın Akalin, H. Acar","doi":"10.31362/patd.1194142","DOIUrl":"https://doi.org/10.31362/patd.1194142","url":null,"abstract":"Aim: The aim of this study is to investigate the effect of dynamic contrast magnetic resonance imaging (DCE-MRI) in the diagnosis of breast cancer (BC) and to compare it with ultrasonography (USG). \u0000Materials and Methods: In our study, 78 patients who underwent preoperative DCE-MRI and USG in our diagnosis center in TRNC between 2009 and 2022 and were diagnosed with BC histopathologically were investigated retrospectively.Findings obtained according to the BI-RADS classification in both methods, detection of BC, detection of tumor foci (TF) in multiple tumors (multicentric and multifocal tumors) (MT), correct diagnosis rates(CDR)s in invasive lobular cancers (ILC) and invasive ductal cancers (IDC) were compared and the results were evaluated statistically. \u0000Results: The mean age of the ILC and MT cases was found to be significantly lower than the IDC and unifocal tumor(UF) cases (p","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73030457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Coagulation Mechanism in the Development of Acute Thrombosed Hemorrhoidal Disease","authors":"Selman Alkan, M. Çakır, A. Varman, Mustafa Şentürk, O. Kişi, A. Topal","doi":"10.31362/patd.1181190","DOIUrl":"https://doi.org/10.31362/patd.1181190","url":null,"abstract":"ABSTRACT \u0000Background Hemorrhoidal disease is a common benign anorectal disease. Acute thrombosis that occurs during the course of hemorrhoidal disease is a painful complication. Factors affecting its etiopathogenesis are not known definitively. The aim of this study, therefore, was to assess predisposition to coagulation during the development of the disease. \u0000Method 30 patients with acute thrombosed hemorrhoidal disease and 30 other patients with hemorrhoidal disease but no thromboses were included in the study. Samples collected from \u0000these patients were analyzed with thromboelastography machines. The results were compared \u0000with patients’ demographic data. \u0000Results No statistically significant difference was found between the groups as per age, sex, diarrhea, history of a similar attack, history of surgical treatment, spicy food consumption, fibrous food consumption, and regular exercise. The results of our study revealed that the alpha angle was smaller in patients with acute \u0000thrombosed hemorrhoidal disease. \u0000Conclusion Hypercoagulability does not occur in patients with acute thrombosed hemorrhoidal disease","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81125746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Continuous Renal Replacement Therapy Results Applied in the Intensive Care Unit","authors":"İ. H. Akbudak, Çağla Erdoğan, I. Akbudak","doi":"10.31362/patd.1198297","DOIUrl":"https://doi.org/10.31362/patd.1198297","url":null,"abstract":"Purpose: Acute kidney injury diagnosed patients are in need of renal replacement therapy (RRT). Continuous RRT is believed to be safer because the rates of fluid and solute removal are slower than with intermittent hemodialysis. In many centers, CRRT is preferred in special conditions such as increased cranial pressure, sepsis, burns, heart and liver failure. In our study, we present one year data of CRRT usage in our ICU. \u0000Materials and methods: This study included the patients who admitted to the Internal Medicine Intensive Care Unit of our university between January 2019 and June 2020. Among these patients, those over 18 years of age and those who had acute renal failure during their hospitalization and received continuous renal replacement therapy were included in the study. \u0000Results: Mean SOFA scores at admission were 2.7 which is an indication for severe disease. Lengths of ICU stay were long and approximately 77 percent of these patients died in ICU. When the comorbid conditions of the patients were examined, it was seen that oncological diseases were the most common. It was followed by hypertension, diabetes mellitus and heart diseases. Considering the KDIGO scores of the patients diagnosed with AKI, it was seen that 60 percent of them were grade 5. Treatment could be applied for an average of 25 hours. \u0000Conclusion: Indications, timing and benefits of CRRT are the questions that need to be research and yet remained unsolved. With evolving of technology, CRRT will be our most useful helper in ICUs.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88154911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}