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Pharmacological research communications最新文献

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Effects of gangliosides on the formation of eicosanoids in rat brain cerebral ischemia and reperfusion 神经节苷类对大鼠脑缺血再灌注后类二十烷酸形成的影响
Pharmacological research communications
Pub Date : 1988-12-01 DOI: 10.1016/S0031-6989(88)80850-6
Bertazzo A., Petroni A., Sarti S., Colombo C., Galli C.
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引用次数: 0
Anti-inflammatory activity of benzopyrones that are inhibitors of cyclo- and lipo-oxygenase 环氧化酶和脂氧化酶抑制剂苯并吡酮类药物的抗炎活性
Pharmacological research communications
Pub Date : 1988-12-01 DOI: 10.1016/S0031-6989(88)80849-X
R. Della Loggia , E. Ragazzi , A. Tubaro , G. Fassina , R. Vertua

The anti-inflammatory activity of three benzo-pyrones with prevalent lipooxigenase-inhibitory activity was studied using the Croton oil ear test in mice, in comparison with nordihydroguaieretic acid (NDGA) and indomethacin. Kaempferol, quercetin and NOGA possess a strong and prolonged anti-inflammatory effect, whereas the action of indomethacin appears relevant, but not long-lasting. In contrast the anti-inflammatory activity of esculetin is rather weak, but persistent.

采用巴豆油耳试验研究了3种具有抑制脂氧化酶活性的苯并吡酮类化合物的抗炎活性，并与去甲双氢愈创酸(NDGA)和吲哚美辛进行了比较。山奈酚、槲皮素和NOGA具有强而持久的抗炎作用，而吲哚美辛的作用似乎相关，但不持久。相反，皮素的抗炎活性较弱，但具有持久性。
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引用次数: 39
Inhibitory activity of 2-benzimidazolylurea on gastric acid secretion in rats 2-苯并咪唑脲对大鼠胃酸分泌的抑制作用
Pharmacological research communications
Pub Date : 1988-12-01 DOI: 10.1016/S0031-6989(88)80725-2
S. Trivulzio

2-Benzimidazolylurea (BIU) decreases gastric acid secretion. The antisecretive activity appears to be associated with antihistaminic and antimuscarinic effects.

The antihistaminic activity of BIU appears from its inhibitory effects on betazole stimulated gastric acid secretion and from its inhibitory activity on the isolated guinea pig auricle stimulated by betazole.

The antimuscarinic activity of BIU appears from several experiments: this molecule decreases gastric acid secretion stimulated by carbachol in rats, depresses the neostigmine-stimulated motility of duodenum in the anaesthetized cat, lessens the hypertonus of isolated guinea pig trachea caused by pylocarpine and also inhibits guinea pig ileum activity stimulated by acetylcholine.

BIU probably depresses gastric acid secretion by interferring with both histamine and acetylcholine receptors.

2-苯并咪唑脲(BIU)减少胃酸分泌。抗隐活性似乎与抗组胺和抗毒作用有关。BIU的抗组胺活性主要表现在其对倍唑刺激下的胃酸分泌的抑制作用和对离体豚鼠耳廓的抑制作用。BIU的抗毒蕈碱活性出现在几个实验中:该分子能降低大鼠受碳巴酚刺激的胃酸分泌，抑制麻醉猫受新斯的明刺激的十二指肠运动，减轻幽门卡平引起的离体豚鼠气管张力增高，还能抑制乙酰胆碱刺激的豚鼠回肠活性。BIU可能通过干扰组胺和乙酰胆碱受体抑制胃酸分泌。
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引用次数: 0
5-HT3 receptors antagonists block morphine- and nicotine- but not amphetamine-induced place-preference conditioning 5-HT3受体拮抗剂阻断吗啡和尼古丁，但不阻断安非他明诱导的位置偏好条件反射
Pharmacological research communications
Pub Date : 1988-12-01 DOI: 10.1016/S0031-6989(88)80752-5
E. Acquas, E. Carboni, P. Leone, G. Di Chiara
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引用次数: 25
Debrisoquine oxidation in schizophrenic patients treated with neuroleptics 抗精神病药治疗精神分裂症患者的碎片喹氧化
Pharmacological research communications
Pub Date : 1988-12-01 DOI: 10.1016/S0031-6989(88)80747-1
E. Spina , A.L. Buemi , A.P. Caputi , J. Benitez , J. Cobaleda , M.A. Garcia , A. Llerena , B. Piña
{"title":"Debrisoquine oxidation in schizophrenic patients treated with neuroleptics","authors":"E. Spina ,&nbsp;A.L. Buemi ,&nbsp;A.P. Caputi ,&nbsp;J. Benitez ,&nbsp;J. Cobaleda ,&nbsp;M.A. Garcia ,&nbsp;A. Llerena ,&nbsp;B. Piña","doi":"10.1016/S0031-6989(88)80747-1","DOIUrl":"10.1016/S0031-6989(88)80747-1","url":null,"abstract":"","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 12","pages":"Pages 1103-1104"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80747-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14042082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Role of G-proteins in mediating dihydropyridine receptor coupling with voltage sensitive calcium channels g蛋白介导二氢吡啶受体偶联与电压敏感钙通道的作用
Pharmacological research communications
Pub Date : 1988-12-01 DOI: 10.1016/S0031-6989(88)80737-9
O. Meucci, T. Florio, M. Grimaldi, E. Landolfi, G. Magri, G. Schettini
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引用次数: 1
Effects of kassinin, a tachykinin of the skin of the African frog Kassina senegalensis, on body fluid homeostasis in rats 非洲蛙皮肤的一种快速激肽卡西尼对大鼠体液稳态的影响
Pharmacological research communications
Pub Date : 1988-12-01 DOI: 10.1016/S0031-6989(88)80843-9
Perfumi M. , do Caro G. , Panocka I. , Polidori C. , Massi M.

In Wistar rats loaded with SC hypartonic NaCl solution kassinin producos an inhibition of cell-dehydration drinking which lasts soveral hours. The long duration of the effect does not depend on a renal excretion of sodium but, hypothetically, on a redistribution of electrolytes between the extra- and the intra-cellular compartments of body fluids.

在Wistar大鼠体内，SC钠离子NaCl溶液对细胞脱水产生持续数小时的抑制作用。这种效果的长时间持续并不取决于钠的肾脏排泄，而是根据假设，取决于体液的细胞外和细胞内隔间之间电解质的重新分配。
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引用次数: 1
Anti-inflammatory and peripheral analgesic activity of esculetin in vivo 槲皮素在体内的抗炎和外周镇痛活性
Pharmacological research communications
Pub Date : 1988-12-01 DOI: 10.1016/S0031-6989(88)80847-6
A. Tubaro , P. Del Negro , E. Ragazzi , S. Zampiron , R. Della Loggia

Esculetin determined a reduction in oedema and granulocyte infiltration in the Croton oil ear test in vivo. The drug was able to inhibit Acethylcholine-writhing test and showed a LD50 of 1450 mg/kg i.p. and > 2000 mg/kg by mouth. In our experimental conditions, esculetin has an anti-inflammatory and analgesic effect.

在体内巴豆油耳试验中，埃斯维丁确定了水肿和粒细胞浸润的减少。该药物对乙酰胆碱扭体试验具有抑制作用，LD50为1450 mg/kg。口服2000mg /kg。在我们的实验条件下，橙皮素具有抗炎和镇痛作用。
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引用次数: 49
Dopamine D-2 receptors in the ventral tegmental area mediate behavioural and electrocortical sleep of dopaminergic drugs in rats 大鼠腹侧被盖区多巴胺D-2受体介导多巴胺能药物的行为和皮层电睡眠
Pharmacological research communications
Pub Date : 1988-12-01 DOI: 10.1016/S0031-6989(88)80741-0
Giacinto Bagetta, Elisabetta Priolo, Giuseppe Nistico
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引用次数: 5
Involvement of the Na+-H+ antiporter on the effect of protein kinase-C activation on dopamine synthesis in rat corpus striatum Na+-H+反向转运蛋白参与大鼠纹状体蛋白激酶c激活对多巴胺合成的影响
Pharmacological research communications
Pub Date : 1988-12-01 DOI: 10.1016/S0031-6989(88)80745-8
S. Amoroso , L. Annuziato , M. Taglialatela , G.F. Di Renzo , L.M.T. Canzoniero , G. Galizia , A. Marino
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引用次数: 0
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