Textile industry wastewater contaminated with dye effluents poses a significant environmental challenge. Numerous nanoparticles are used as adsorbents to treat similarly stimulated wastewater, but particularly nanomaterials synthesized through green methods have gained prominence. To assess their practical applicability in addressing real‐world textile wastewater pollution, studies on dye removal from authentic textile industrial effluents are recommended. As a result, a study focused on the removal of dye from real textile industrial effluent is conducted, and biosynthesized copper oxide nanoparticles and iron oxide nanorods are chosen as adsorbents. The investigation scrutinized the influence of adsorbent dosage, adsorbent‐adsorbate contact time, and wastewater pH on the percentage of dye adsorption. These findings indicate that increasing the adsorbent dosage and contact time leads to a higher percentage of dye removal. Notably, copper oxide nanoparticles exhibit superior dye removal efficiency at pH levels 5 and 7, outperforming the maximum dye removal efficiency of iron oxide nanorods at pH 12. The study achieved an impressive process efficiency of 95.24% for copper oxide nanoparticles and 62.5% for iron oxide nanorods. Response surface methodology (RSM) is employed for statistical data analysis and optimization of dye removal process parameters to maximize efficiency. Overall, the results demonstrate that biosynthesized nanomaterials offer a promising and effective solution for removing dyes from textile industrial wastewater.
{"title":"Utilization of Eco‐friendly Copper Oxide Nanoparticles and Iron Oxide Nanorods in Dye Removal from Real Textile Industry Effluent","authors":"Mohd Yousuf Rather, Somaiah Sundarapandian","doi":"10.1002/ppsc.202300223","DOIUrl":"https://doi.org/10.1002/ppsc.202300223","url":null,"abstract":"Textile industry wastewater contaminated with dye effluents poses a significant environmental challenge. Numerous nanoparticles are used as adsorbents to treat similarly stimulated wastewater, but particularly nanomaterials synthesized through green methods have gained prominence. To assess their practical applicability in addressing real‐world textile wastewater pollution, studies on dye removal from authentic textile industrial effluents are recommended. As a result, a study focused on the removal of dye from real textile industrial effluent is conducted, and biosynthesized copper oxide nanoparticles and iron oxide nanorods are chosen as adsorbents. The investigation scrutinized the influence of adsorbent dosage, adsorbent‐adsorbate contact time, and wastewater pH on the percentage of dye adsorption. These findings indicate that increasing the adsorbent dosage and contact time leads to a higher percentage of dye removal. Notably, copper oxide nanoparticles exhibit superior dye removal efficiency at pH levels 5 and 7, outperforming the maximum dye removal efficiency of iron oxide nanorods at pH 12. The study achieved an impressive process efficiency of 95.24% for copper oxide nanoparticles and 62.5% for iron oxide nanorods. Response surface methodology (RSM) is employed for statistical data analysis and optimization of dye removal process parameters to maximize efficiency. Overall, the results demonstrate that biosynthesized nanomaterials offer a promising and effective solution for removing dyes from textile industrial wastewater.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"54 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140596677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Recent research on supercapacitors (SCs) has been attractive due to the potential application in a variety of fields related to energy storage. Electrode materials play a very important role for the performance of SCs and various metal nanoparticles are involved in the SC electrodes. In this paper, the roles of metal nanoparticles for SCs are reviewed and discussed. They can serve as a dopant to modify the surface of electrode materials, or be embedded in a composite to effectively reduce the resistance and lead to an enhanced specific capacitance. Some metal nanoparticles can be also employed as electrode materials directly, but easily being oxidized. Metallic nanoparticles can even act as current collectors, especially for these noble metals with excellent stability and high conductivity. Nanoporous metals prepared by dealloying and electrochemical method can be used as both pseudocapacitive materials and current collector of SCs. Some important experimental data on this issue are summarized. A brief discussion on the future directions, challenges and opportunities in this topic is also provided.
{"title":"Roles of Metal Nanoparticles for Supercapacitors: A Review","authors":"Ailan Yan, Xinchang Wang, Jipeng Cheng","doi":"10.1002/ppsc.202400002","DOIUrl":"https://doi.org/10.1002/ppsc.202400002","url":null,"abstract":"Recent research on supercapacitors (SCs) has been attractive due to the potential application in a variety of fields related to energy storage. Electrode materials play a very important role for the performance of SCs and various metal nanoparticles are involved in the SC electrodes. In this paper, the roles of metal nanoparticles for SCs are reviewed and discussed. They can serve as a dopant to modify the surface of electrode materials, or be embedded in a composite to effectively reduce the resistance and lead to an enhanced specific capacitance. Some metal nanoparticles can be also employed as electrode materials directly, but easily being oxidized. Metallic nanoparticles can even act as current collectors, especially for these noble metals with excellent stability and high conductivity. Nanoporous metals prepared by dealloying and electrochemical method can be used as both pseudocapacitive materials and current collector of SCs. Some important experimental data on this issue are summarized. A brief discussion on the future directions, challenges and opportunities in this topic is also provided.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"136 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140324902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yufang Ren, Zeyuan Sun, Yong Huang, Xiaoyan An, Xiaona Bian, Zhenhao Cao, Yifan Liu, Kanwal Javed, Tetiana Derkach, Xue Li
TiO2 is a widely used photocatalytic antibacterial material and shows good antibacterial properties under ultraviolet light. However, its antibacterial efficacy under visible light still remains limited. To develop low-cost and biocompatible antibacterial materials, this article provides a facile method for in situ preparation of a trace amount of silver (Ag) doped TiO2 nanorods (TiO2NR–Ag) composites, which cannot only enhance the antibacterial properties under visible light, but also has good biocompatibility. Two representative epidemic strains, Staphylococcus aureus and Escherichia coli, are selected for analysis of the antibacterial properties of the obtained TiO2NR–Ag composite nanoparticles. The results demonstrate that even if the Ag doping level is as low as 2.5 × 10−4 wt% (i.e., Ag/TiO2 = 2.50 µg g−1), the TiO2NR–Ag composite nanoparticle coatings are transparent and exhibit exceptional antibacterial properties, which is attributed to synergistic enhanced bactericidal effect of the active substances generated by TiO2NR–Ag under visible light. The cytotoxicity and hemolysis rate results indicate that TiO2NR–Ag composite exhibit excellent biocompatibility. This study effectively improves the antibacterial effect of TiO2 photocatalytic nanomaterials while maintaining their biocompatibility, and the prepared TiO2NR–Ag composite nanoparticles can be applied in various fields such as window glasses, medical device surfaces, furniture surfaces, and optical devices, etc.
{"title":"Preparation of TiO2 Nanorods Composites Doped with Silver Nanoparticles and Their Bactericidal Properties under Visible Light Irradiation","authors":"Yufang Ren, Zeyuan Sun, Yong Huang, Xiaoyan An, Xiaona Bian, Zhenhao Cao, Yifan Liu, Kanwal Javed, Tetiana Derkach, Xue Li","doi":"10.1002/ppsc.202300191","DOIUrl":"https://doi.org/10.1002/ppsc.202300191","url":null,"abstract":"TiO<sub>2</sub> is a widely used photocatalytic antibacterial material and shows good antibacterial properties under ultraviolet light. However, its antibacterial efficacy under visible light still remains limited. To develop low-cost and biocompatible antibacterial materials, this article provides a facile method for in situ preparation of a trace amount of silver (Ag) doped TiO<sub>2</sub> nanorods (TiO<sub>2</sub>NR–Ag) composites, which cannot only enhance the antibacterial properties under visible light, but also has good biocompatibility. Two representative epidemic strains, <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>, are selected for analysis of the antibacterial properties of the obtained TiO<sub>2</sub>NR–Ag composite nanoparticles. The results demonstrate that even if the Ag doping level is as low as 2.5 × 10<sup>−4</sup> wt% (i.e., Ag/TiO<sub>2</sub> = 2.50 µg g<sup>−1</sup>), the TiO<sub>2</sub>NR–Ag composite nanoparticle coatings are transparent and exhibit exceptional antibacterial properties, which is attributed to synergistic enhanced bactericidal effect of the active substances generated by TiO<sub>2</sub>NR–Ag under visible light. The cytotoxicity and hemolysis rate results indicate that TiO<sub>2</sub>NR–Ag composite exhibit excellent biocompatibility. This study effectively improves the antibacterial effect of TiO<sub>2</sub> photocatalytic nanomaterials while maintaining their biocompatibility, and the prepared TiO<sub>2</sub>NR–Ag composite nanoparticles can be applied in various fields such as window glasses, medical device surfaces, furniture surfaces, and optical devices, etc.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"70 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140301543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hemra Hamrayev, Seyed Davoud Jazayeri, Mostafa Yusefi, Brianna, Sin-Yeang Teow, Yuan Seng Wu, Ayaz Anwar, Serdar Korpayev, Aras Kartouzian, Kamyar Shameli
In this study, zinc oxide nanoparticles (ZnO-NPs) are synthesized and combined with chitosan (Cs) to create Cs/ZnO-NPs nanomicelles, aiming to investigate their potential as a novel cancer treatment. The ZnO-NPs are produced through a sintering process at temperatures ranging from 300 to 700 °C. The most effective nanoparticles are obtained at 600 °C, as determined by X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR) analyses, which confirmed their crystallinity and purity. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) are employed to characterize the size and shape of the nanoparticles, revealing predominantly spherical and hexagonal structures with stable dimensions. The cytotoxic effects of the Cs/ZnO-NPs are evaluated against various cancer cell types. The results show that at a concentration of 125 µg mL−1, the Cs/ZnO-NPs demonstrate significantly higher cancer cell toxicity compared to ZnO-NPs alone, while remaining non-toxic to normal cells. This indicates that Cs/ZnO-NPs have a superior ability to selectively target cancer cells. These findings suggest that Cs/ZnO-NPs nanomicelles hold promise as an effective and safe nanotherapeutic approach in the realm of cancer treatment, meriting further exploration for clinical applications.
本研究合成了氧化锌纳米粒子（ZnO-NPs），并将其与壳聚糖（Cs）结合制成 Cs/ZnO-NPs 纳米微球，旨在研究其作为新型癌症治疗方法的潜力。ZnO-NPs 是在 300 至 700 °C 的温度下通过烧结工艺制得的。经 X 射线衍射（XRD）和傅立叶变换红外光谱（FTIR）分析确定，在 600 °C 时获得的纳米粒子效果最好，这证实了它们的结晶度和纯度。透射电子显微镜（TEM）和扫描电子显微镜（SEM）用于表征纳米粒子的尺寸和形状，结果显示它们主要呈尺寸稳定的球形和六边形结构。评估了 Cs/ZnO-NPs 对各种癌症细胞的细胞毒性作用。结果表明，在 125 µg mL-1 的浓度下，Cs/ZnO-NPs 的癌细胞毒性明显高于单独的 ZnO-NPs，而对正常细胞则无毒性。这表明 Cs/ZnO-NPs 具有更强的选择性靶向癌细胞的能力。这些研究结果表明，Cs/ZnO-NPs 纳米微孔有望成为癌症治疗领域一种有效、安全的纳米治疗方法，值得进一步探索其临床应用。
{"title":"Green Chemical Approach for the Synthesis of ZnO Nanoparticles and Investigation of their Cytotoxicity","authors":"Hemra Hamrayev, Seyed Davoud Jazayeri, Mostafa Yusefi, Brianna, Sin-Yeang Teow, Yuan Seng Wu, Ayaz Anwar, Serdar Korpayev, Aras Kartouzian, Kamyar Shameli","doi":"10.1002/ppsc.202400009","DOIUrl":"https://doi.org/10.1002/ppsc.202400009","url":null,"abstract":"In this study, zinc oxide nanoparticles (ZnO-NPs) are synthesized and combined with chitosan (Cs) to create Cs/ZnO-NPs nanomicelles, aiming to investigate their potential as a novel cancer treatment. The ZnO-NPs are produced through a sintering process at temperatures ranging from 300 to 700 °C. The most effective nanoparticles are obtained at 600 °C, as determined by X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR) analyses, which confirmed their crystallinity and purity. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) are employed to characterize the size and shape of the nanoparticles, revealing predominantly spherical and hexagonal structures with stable dimensions. The cytotoxic effects of the Cs/ZnO-NPs are evaluated against various cancer cell types. The results show that at a concentration of 125 µg mL<sup>−1</sup>, the Cs/ZnO-NPs demonstrate significantly higher cancer cell toxicity compared to ZnO-NPs alone, while remaining non-toxic to normal cells. This indicates that Cs/ZnO-NPs have a superior ability to selectively target cancer cells. These findings suggest that Cs/ZnO-NPs nanomicelles hold promise as an effective and safe nanotherapeutic approach in the realm of cancer treatment, meriting further exploration for clinical applications.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"16 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140324926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The corrosion inhibition performance of air nanobubbles (A-NBs) is expected to address the environmental problems arising from chemical corrosion. In order to regulate the corrosion inhibition performance of A-NBs, the particle characteristics of A-NBs in flowing composite salt solutions are investigated, and the corrosion inhibition effect of A-NBs under different concentration ratios and rotational speed of simulated circulating cooling water is studied. High salt concentrations significantly reduced the particle size, concentration, and zeta-potential value of A-NBs, thus reducing the stability of A-NBs. The flow velocity has a slight effect on A-NBs. The results of the weight loss and electrochemical method showed that A-NBs achieved the highest corrosion inhibition rate of 55% under a concentration ratio of 1.5 and a rotational speed of 100 r min−1. The surface characterization of brass specimens revealed that A-NBs facilitated the formation of Cu2(OH)2CO3 passivation film, calcium carbonate scale film, and a layer of bubbles on the surface of brass, which subsequently mitigated the erosive impact of the fluid. A-NBs can adsorb cations and thus reduce the concentration of corrosive ions. However, the increase in concentration ratio and rotational speed impeded the formation of the bubble layer and passivation film.
{"title":"Particle Properties of Air Nanobubbles and Their Inhibition Mechanism on Brass Corrosion in Recirculating Cooling Water: Effects of Concentration Ratio and Flow Velocity","authors":"Yuling Zhang, Haiyang Duan, Shaolei Lu, Shaoxia Yang, Yaqin Qiu, Songtao Liu, Yinwei Wu","doi":"10.1002/ppsc.202300224","DOIUrl":"https://doi.org/10.1002/ppsc.202300224","url":null,"abstract":"The corrosion inhibition performance of air nanobubbles (A-NBs) is expected to address the environmental problems arising from chemical corrosion. In order to regulate the corrosion inhibition performance of A-NBs, the particle characteristics of A-NBs in flowing composite salt solutions are investigated, and the corrosion inhibition effect of A-NBs under different concentration ratios and rotational speed of simulated circulating cooling water is studied. High salt concentrations significantly reduced the particle size, concentration, and zeta-potential value of A-NBs, thus reducing the stability of A-NBs. The flow velocity has a slight effect on A-NBs. The results of the weight loss and electrochemical method showed that A-NBs achieved the highest corrosion inhibition rate of 55% under a concentration ratio of 1.5 and a rotational speed of 100 r min<sup>−1</sup>. The surface characterization of brass specimens revealed that A-NBs facilitated the formation of Cu<sub>2</sub>(OH)<sub>2</sub>CO<sub>3</sub> passivation film, calcium carbonate scale film, and a layer of bubbles on the surface of brass, which subsequently mitigated the erosive impact of the fluid. A-NBs can adsorb cations and thus reduce the concentration of corrosive ions. However, the increase in concentration ratio and rotational speed impeded the formation of the bubble layer and passivation film.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"27 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140301362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cover image provided courtesy of Tymish Y. Ohulchanskyy, Junle Qu, Anderson S. L. Gome, and co-workers.
封面图片由 Tymish Y. Ohulchanskyy、Junle Qu、Anderson S. L. Gome 及合作者提供。
{"title":"(Part. Part. Syst. Charact. 3/2024)","authors":"","doi":"10.1002/ppsc.202470030","DOIUrl":"https://doi.org/10.1002/ppsc.202470030","url":null,"abstract":"Cover image provided courtesy of Tymish Y. Ohulchanskyy, Junle Qu, Anderson S. L. Gome, and co-workers.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"23 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140200186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas Girardet, Morgane Kessler, Sylvie Migot, Lionel Aranda, Sébastien Diliberto, Stéphane Suire, Tom Ferté, Sébastien Hupont, Franck Cleymand, Solenne Fleutot
Superparamagnetic iron oxide nanoparticles (SPIONs) are nanoparticles used in a lot of applications such as batteries, and biomedical, … To obtain these nanoparticles, several techniques exist such as coprecipitation, thermal decomposition, sol–gel process but they have some advantages (synthesis in a water media, high crystallinity, high monodispersity) and disadvantages (using an organic solvent, large distribution of size, poor crystallinity). The goal of this work is to synthesize SPIONs for biomedical applications (for example as a contrast agent for the MRI): SPIONs should be stable in an aqueous media, monodisperse, and have good crystallinity and magnetic properties. To achieve this result, a microwave process is carried out. However, any study describes the microwave parameter on the synthesis of the nanoparticles. This work offers to determine the best conditions of the microwave to obtain ideal SPIONs for MRI. For this, an experimental design is carried out to determine these parameters thanks to different techniques of characterization (Transmission Electronic Microscopy, Dynamic Light Scattering, X-ray diffraction, Thermogravimetric Analysis, magnetic characterizations). With the different results of these characterizations, the best conditions of the microwave are determined, and a simulation of all experiments is realized with a surface response.
{"title":"One Step Superparamagnetic Iron Oxide Nanoparticles by a Microwave Process: Optimization of Microwave Parameters with an Experimental Design","authors":"Thomas Girardet, Morgane Kessler, Sylvie Migot, Lionel Aranda, Sébastien Diliberto, Stéphane Suire, Tom Ferté, Sébastien Hupont, Franck Cleymand, Solenne Fleutot","doi":"10.1002/ppsc.202300226","DOIUrl":"https://doi.org/10.1002/ppsc.202300226","url":null,"abstract":"Superparamagnetic iron oxide nanoparticles (SPIONs) are nanoparticles used in a lot of applications such as batteries, and biomedical, … To obtain these nanoparticles, several techniques exist such as coprecipitation, thermal decomposition, sol–gel process but they have some advantages (synthesis in a water media, high crystallinity, high monodispersity) and disadvantages (using an organic solvent, large distribution of size, poor crystallinity). The goal of this work is to synthesize SPIONs for biomedical applications (for example as a contrast agent for the MRI): SPIONs should be stable in an aqueous media, monodisperse, and have good crystallinity and magnetic properties. To achieve this result, a microwave process is carried out. However, any study describes the microwave parameter on the synthesis of the nanoparticles. This work offers to determine the best conditions of the microwave to obtain ideal SPIONs for MRI. For this, an experimental design is carried out to determine these parameters thanks to different techniques of characterization (Transmission Electronic Microscopy, Dynamic Light Scattering, X-ray diffraction, Thermogravimetric Analysis, magnetic characterizations). With the different results of these characterizations, the best conditions of the microwave are determined, and a simulation of all experiments is realized with a surface response.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"39 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140149720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Levi Collin Nelemans, Ghizlane Choukrani, Natasha Ustyanovska‐Avtenyuk, Valerie R Wiersma, Lars Dähne, Edwin Bremer
Despite clinical advances in immunotherapy, still many therapeutics cause dose‐limiting (auto)immune‐mediated toxicities. Nanoparticle‐based drug delivery systems (DDS) can improve cancer immunotherapy through site‐specific delivery and controlled release of immunotherapeutics in the tumor microenvironment (TME). However, DDS face several challenges, including unspecific release. To address this, vaterite nanoparticles (VNPs) that selectively release immunotherapeutic proteins at low pH conditions find in the TME, are established previously. In the current study, these VNPs are further modified for active targeting without affecting the loaded protein activity, exemplified with Tumor Necrosis Factor α (TNF). Specifically, VNPs are coated with gelatin, a matrix‐metalloprotease sensitive polymer which provides functional groups for further conjugation. Subsequently, streptavidin is covalently linked to the gelatin shell by amine‐epoxy chemistry, enabling coupling of any biotinylated ligand. Exemplified by biotinylated cetuximab and rituximab, targeted VNPs selectively bind to cells expressing epidermal growth factor receptor (EGFR) or CD20, respectively. Importantly, TNF remains functionally active after the modification steps, as VNP treatment increased ICAM‐1 expression on FaDu cells and activated NFκB signaling in a Jurkat.NFκB‐luciferase cell line model. In conclusion, a targetable vaterite‐based DDS is produced that allows for easy surface modification with any biotinylated ligand that may find broad applications in tumor‐selective immunotherapy.
{"title":"Design of Vaterite Nanoparticles for Controlled Delivery of Active Immunotherapeutic Proteins","authors":"Levi Collin Nelemans, Ghizlane Choukrani, Natasha Ustyanovska‐Avtenyuk, Valerie R Wiersma, Lars Dähne, Edwin Bremer","doi":"10.1002/ppsc.202300153","DOIUrl":"https://doi.org/10.1002/ppsc.202300153","url":null,"abstract":"Despite clinical advances in immunotherapy, still many therapeutics cause dose‐limiting (auto)immune‐mediated toxicities. Nanoparticle‐based drug delivery systems (DDS) can improve cancer immunotherapy through site‐specific delivery and controlled release of immunotherapeutics in the tumor microenvironment (TME). However, DDS face several challenges, including unspecific release. To address this, vaterite nanoparticles (VNPs) that selectively release immunotherapeutic proteins at low pH conditions find in the TME, are established previously. In the current study, these VNPs are further modified for active targeting without affecting the loaded protein activity, exemplified with Tumor Necrosis Factor α (TNF). Specifically, VNPs are coated with gelatin, a matrix‐metalloprotease sensitive polymer which provides functional groups for further conjugation. Subsequently, streptavidin is covalently linked to the gelatin shell by amine‐epoxy chemistry, enabling coupling of any biotinylated ligand. Exemplified by biotinylated cetuximab and rituximab, targeted VNPs selectively bind to cells expressing epidermal growth factor receptor (EGFR) or CD20, respectively. Importantly, TNF remains functionally active after the modification steps, as VNP treatment increased ICAM‐1 expression on FaDu cells and activated NFκB signaling in a Jurkat.NFκB‐luciferase cell line model. In conclusion, a targetable vaterite‐based DDS is produced that allows for easy surface modification with any biotinylated ligand that may find broad applications in tumor‐selective immunotherapy.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"35 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140129570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vidyasagar P. Phase, Sharanabasappa S. Kammar, Chandrashekhar S. Munnolli, Yashwant S. Madansure, Ahmed A. Ibrahim, Khalid M. Batoo, Ram H. Kadam, Sagar E. Shirsath, Anil R. Shitre
A mixture of soft–hard (S–H) ferrites with the general chemical formula (1-x) Ni0.5Cu0.25Zn0.25Fe2O4 (NCZFO) + (x) SrFe11Y1O19 (SFYO) is developed via sol-gel auto-combustion and their physical mixing. X-ray diffraction (XRD), Fourier transform infrared spectroscopy, field emission scanning electron microscopy (SEM) coupled with energy dispersive X-ray spectroscopy, high-resolution transmission electron microscopy (HRTEM), vibrating sample magnetometry (VSM) and two-probe technique are used to examine the resultant materials. Rietveld refinement of XRD data confirms the co-existence of both soft and hard phases in the composites. The HRTEM and FESEM results confirm the nanocrystalline nature of the synthesized particles. Williamson-Hall method is employed to reveal the strain nature in soft and hard phases. VSM analysis shows considerable changes in the magnetic characteristics for the different composition of NCZFO and SFYO. The exchange-spring mechanism is discussed in the manuscript.
{"title":"Strain and Exchange-Spring Mechanism of (1-x) Ni0.5Cu0.25Zn0.25Fe2O4 + (x) SrFe11Y1O19 Magnetically Soft–Hard Ferrite Composed Nanoparticles","authors":"Vidyasagar P. Phase, Sharanabasappa S. Kammar, Chandrashekhar S. Munnolli, Yashwant S. Madansure, Ahmed A. Ibrahim, Khalid M. Batoo, Ram H. Kadam, Sagar E. Shirsath, Anil R. Shitre","doi":"10.1002/ppsc.202300225","DOIUrl":"https://doi.org/10.1002/ppsc.202300225","url":null,"abstract":"A mixture of soft–hard (S–H) ferrites with the general chemical formula (1-<i>x</i>) Ni<sub>0.5</sub>Cu<sub>0.25</sub>Zn<sub>0.25</sub>Fe<sub>2</sub>O<sub>4</sub> (NCZFO) + (<i>x</i>) SrFe<sub>11</sub>Y<sub>1</sub>O<sub>19</sub> (SFYO) is developed via sol-gel auto-combustion and their physical mixing. X-ray diffraction (XRD), Fourier transform infrared spectroscopy, field emission scanning electron microscopy (SEM) coupled with energy dispersive X-ray spectroscopy, high-resolution transmission electron microscopy (HRTEM), vibrating sample magnetometry (VSM) and two-probe technique are used to examine the resultant materials. Rietveld refinement of XRD data confirms the co-existence of both soft and hard phases in the composites. The HRTEM and FESEM results confirm the nanocrystalline nature of the synthesized particles. Williamson-Hall method is employed to reveal the strain nature in soft and hard phases. VSM analysis shows considerable changes in the magnetic characteristics for the different composition of NCZFO and SFYO. The exchange-spring mechanism is discussed in the manuscript.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"29 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140115292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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