Skin disorders are the most common apprehension worldwide among different regions of the world. Topical route of administration offers benefits over other routes such as avoidance of first‐pass metabolism, low dose, longer residence time, and absence of off‐target delivery. Skin serves as a mechanical barrier for therapeutic delivery with selectively permeable essential molecules. Considering the structural complexity of skin, delivery of therapeutics at targeted site requires sophisticated method such as nanotechnology‐assisted therapeutic delivery. The roadmap for combinatorial approach of nanotechnology and skin therapeutics has proven significant in clinical and marketed products. Currently, various pharmaceutical aids such as nanocrystal (NCs), nanoparticles, nanoemulsion, nano‐micelles, nano lipidic carriers, and hybrid nanocarriers are currently in market. Among all the other nanocarriers, nanocrystal offers precedence over other nanocarriers due to its facile method of preparation, reproducibility, low excipient concentration, and high therapeutic loading capacity. The recent literature data suggest the breakthrough evolution of NCs in topical therapeutic delivery. The outcome of these interventions envisages the applicability of NCs for delivering molecules with compromised physicochemical characteristics such as solubility, stability, toxicity, and bioavailability concerns.
{"title":"Nanocrystals: A Multifaceted Regimen for Dermatological Ailments","authors":"Vaibhavi Giradkar, Akshada Mhaske, Rahul Shukla","doi":"10.1002/ppsc.202300147","DOIUrl":"https://doi.org/10.1002/ppsc.202300147","url":null,"abstract":"Skin disorders are the most common apprehension worldwide among different regions of the world. Topical route of administration offers benefits over other routes such as avoidance of first‐pass metabolism, low dose, longer residence time, and absence of off‐target delivery. Skin serves as a mechanical barrier for therapeutic delivery with selectively permeable essential molecules. Considering the structural complexity of skin, delivery of therapeutics at targeted site requires sophisticated method such as nanotechnology‐assisted therapeutic delivery. The roadmap for combinatorial approach of nanotechnology and skin therapeutics has proven significant in clinical and marketed products. Currently, various pharmaceutical aids such as nanocrystal (NCs), nanoparticles, nanoemulsion, nano‐micelles, nano lipidic carriers, and hybrid nanocarriers are currently in market. Among all the other nanocarriers, nanocrystal offers precedence over other nanocarriers due to its facile method of preparation, reproducibility, low excipient concentration, and high therapeutic loading capacity. The recent literature data suggest the breakthrough evolution of NCs in topical therapeutic delivery. The outcome of these interventions envisages the applicability of NCs for delivering molecules with compromised physicochemical characteristics such as solubility, stability, toxicity, and bioavailability concerns.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"49 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140044081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Weihan Shu, Jiang Gong, Hanqing Zhang, Fengling Zheng, Juan Zeng, Xue Wang, Siqian Qin, Chuancai Zhang, Haodong Xue, Bin Dai
Herein, a new template carbonization method is used to prepare calcite-type nano-calcium carbonate (CaCO3) with a core–shell structure using calcium hydroxide as a solute and Pluronic F-127 as a templating and pore-forming agent. Dopamine hydrochloride is added to control the size of calcium hydroxide particles. The morphology, particle size, and crystal type of CaCO3 are characterized via transmission electron microscopy, X-ray diffraction, nanoparticle size, and zeta potentiometer. The creation of core–shell calcium carbonate nanoparticles is examined in relation to reaction circumstances (i.e., additive sequence, additive amount, and additive mixing time), carbonization temperature, liquid flow rate, and templates with varying chain lengths. Furthermore, a discussion is held regarding the formation mechanism of spherical core–shell calcium carbonate that is created using the innovative template carbonization method. The results show that the order, amount, liquid flow rate, and template type of additives have a significant effect on the crystal shape of calcium carbonate nanoparticles. The mixing time of additives has a significant effect on the particle size of calcium carbonate nanoparticles. Interestingly, the thickness of the shell depends on the carbonization temperature, and too slow or too fast flow rate will lead to the formation of cyclic calcium carbonate nanoparticles.
{"title":"Nano-Calcium Carbonate with Core–Shell Structure was Prepared by Dopamine Chelation Using Pluronic F-127 as Template","authors":"Weihan Shu, Jiang Gong, Hanqing Zhang, Fengling Zheng, Juan Zeng, Xue Wang, Siqian Qin, Chuancai Zhang, Haodong Xue, Bin Dai","doi":"10.1002/ppsc.202300199","DOIUrl":"https://doi.org/10.1002/ppsc.202300199","url":null,"abstract":"Herein, a new template carbonization method is used to prepare calcite-type nano-calcium carbonate (CaCO<sub>3</sub>) with a core–shell structure using calcium hydroxide as a solute and Pluronic F-127 as a templating and pore-forming agent. Dopamine hydrochloride is added to control the size of calcium hydroxide particles. The morphology, particle size, and crystal type of CaCO<sub>3</sub> are characterized via transmission electron microscopy, X-ray diffraction, nanoparticle size, and zeta potentiometer. The creation of core–shell calcium carbonate nanoparticles is examined in relation to reaction circumstances (i.e., additive sequence, additive amount, and additive mixing time), carbonization temperature, liquid flow rate, and templates with varying chain lengths. Furthermore, a discussion is held regarding the formation mechanism of spherical core–shell calcium carbonate that is created using the innovative template carbonization method. The results show that the order, amount, liquid flow rate, and template type of additives have a significant effect on the crystal shape of calcium carbonate nanoparticles. The mixing time of additives has a significant effect on the particle size of calcium carbonate nanoparticles. Interestingly, the thickness of the shell depends on the carbonization temperature, and too slow or too fast flow rate will lead to the formation of cyclic calcium carbonate nanoparticles.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"32 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139968053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rhodamine-B grafted carbon dots (RhB-CDs) with double emission fluorescence are developed , one of which has excitation dependence, while the other have not. The prepared RhB-CDs have good dispersibility, uniform spherical shape, and excellent water solubility. They could be used to specifically detect Fe3+ ions in an aqueous solution with the detection limit of 1.1 × 10−6m and with good anti-interference ability, because Fe3+ ions are easier to combine with hydroxyl groups on the surface of RhB-CDs to form aggregates (such as ferric hydroxide) than other metal ions, which lead to the fluorescence quenching of RhB-CDs. Fe3+ ions not only quench the fluorescence intensity of both double emission peaks of RhB-CDs, but also change the relative fluorescence intensity of these two fluorescence emission peaks. Therefore, two different fluorescence analysis methods are used to specifically identify iron ions and the results are consistent with each other. At the same time, the double emission fluorescent RhB-CDs have low hemolysis rate and cytotoxicity, indicating that RhB-CDs do little harm to cells and are further used to detect Fe3+ ions in cells through fluorescence bioimaging. All of the above indicates that the prepared RhB-CDs would have potential application value in detecting iron ions in blood and cells.
{"title":"Dual-Emission Fluorescent Carbon Dots Grafted by Rhodamine-B for Selective Detection of Iron Ion and Bioimaging in Cell","authors":"Xiaoyan Hu, Hao Zou, Renjie Zhuang, Jun Cao, Jiaqi Pan, Chaorong Li, Yingying Zheng","doi":"10.1002/ppsc.202300193","DOIUrl":"https://doi.org/10.1002/ppsc.202300193","url":null,"abstract":"Rhodamine-B grafted carbon dots (RhB-CDs) with double emission fluorescence are developed , one of which has excitation dependence, while the other have not. The prepared RhB-CDs have good dispersibility, uniform spherical shape, and excellent water solubility. They could be used to specifically detect Fe<sup>3+</sup> ions in an aqueous solution with the detection limit of 1.1 × 10<sup>−6</sup> <span>m</span> and with good anti-interference ability, because Fe<sup>3+</sup> ions are easier to combine with hydroxyl groups on the surface of RhB-CDs to form aggregates (such as ferric hydroxide) than other metal ions, which lead to the fluorescence quenching of RhB-CDs. Fe<sup>3+</sup> ions not only quench the fluorescence intensity of both double emission peaks of RhB-CDs, but also change the relative fluorescence intensity of these two fluorescence emission peaks. Therefore, two different fluorescence analysis methods are used to specifically identify iron ions and the results are consistent with each other. At the same time, the double emission fluorescent RhB-CDs have low hemolysis rate and cytotoxicity, indicating that RhB-CDs do little harm to cells and are further used to detect Fe<sup>3+</sup> ions in cells through fluorescence bioimaging. All of the above indicates that the prepared RhB-CDs would have potential application value in detecting iron ions in blood and cells.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"130 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139987761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cover image provided courtesy of Tymish Y. Ohulchanskyy, Junle Qu, Anderson S. L. Gome, and co-workers.
封面图片由 Tymish Y. Ohulchanskyy、Junle Qu、Anderson S. L. Gome 及合作者提供。
{"title":"(Part. Part. Syst. Charact. 2/2024)","authors":"","doi":"10.1002/ppsc.202470027","DOIUrl":"https://doi.org/10.1002/ppsc.202470027","url":null,"abstract":"Cover image provided courtesy of Tymish Y. Ohulchanskyy, Junle Qu, Anderson S. L. Gome, and co-workers.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"11 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139947466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shiwei Xue, Huiling Ding, Zhenghao Xia, Hengbin Mao, Sibo Zhao, Hailong Wang, Bingbing Fan, Gang Shao, Hongliang Xu, Hongxia Lu
Light Emitting Diodes (LEDs) are the key to new generation displays. New semiconductor electron–hole recombination layer is the key to high-performance LEDs. Although all-inorganic quantum dot (QD) materials have the advantages of wide color gamut and narrow emission peaks, they face issues of toxicity of heavy metal ions and stability of QDs, the synthesis method is highly polluting and difficult to achieve industrial production. Thereby, lead-free all-inorganic phosphor with narrow FWHM needs to be explored. A new synthesis method is required to be investigated. All-inorganic Mn2+ bromide (Cs3MnBr5) is easy to synthesize and has low toxicity and superior luminescent properties. However, most synthesis methods rely on liquid-phase reaction systems and cannot achieve highly efficient synthesis. High-energy ball milling is an efficient method and has enormous potential for industrial production. In this paper, this method is used to synthesize Cs3MnBr5, and then Cs/Mn ratio, ball milling time, and ligand usage are studied. Furthermore, a new phase transformation of all-inorganic Mn2+ bromide is discovered, and the mechanism of high-energy ball milling is interpreted combining with phase transformation process. This article brings a new method to synthesis of all-inorganic Mn2+ bromide, explains the mechanism of ball milling, and expands the phase transformation of all-inorganic Mn2+ bromide.
发光二极管（LED）是新一代显示器的关键。新型半导体电子-空穴重组层是实现高性能 LED 的关键。全无机量子点（QD）材料虽然具有色域宽、发射峰窄等优点，但面临重金属离子毒性、QD稳定性等问题，合成方法污染大，难以实现工业化生产。因此，需要探索具有窄 FWHM 的无铅全无机荧光粉。需要研究一种新的合成方法。全无机溴化锰（Cs3MnBr5）易于合成，毒性低，发光性能优越。然而，大多数合成方法都依赖于液相反应体系，无法实现高效合成。高能球磨法是一种高效的方法，在工业生产中具有巨大的潜力。本文利用这种方法合成了 Cs3MnBr5，并对 Cs/Mn 比例、球磨时间和配体用量进行了研究。此外，还发现了全无机 Mn2+ 溴化物的一种新相变，并结合相变过程解释了高能球磨的机理。本文为无机溴化锰的合成提供了一种新方法，解释了球磨机理，拓展了无机溴化锰的相变过程。
{"title":"High-Energy Ball Milling Synthesize All-Inorganic Lead-Free Green Emitting Cs3MnBr5 Crystals","authors":"Shiwei Xue, Huiling Ding, Zhenghao Xia, Hengbin Mao, Sibo Zhao, Hailong Wang, Bingbing Fan, Gang Shao, Hongliang Xu, Hongxia Lu","doi":"10.1002/ppsc.202300190","DOIUrl":"https://doi.org/10.1002/ppsc.202300190","url":null,"abstract":"Light Emitting Diodes (LEDs) are the key to new generation displays. New semiconductor electron–hole recombination layer is the key to high-performance LEDs. Although all-inorganic quantum dot (QD) materials have the advantages of wide color gamut and narrow emission peaks, they face issues of toxicity of heavy metal ions and stability of QDs, the synthesis method is highly polluting and difficult to achieve industrial production. Thereby, lead-free all-inorganic phosphor with narrow FWHM needs to be explored. A new synthesis method is required to be investigated. All-inorganic Mn<sup>2+</sup> bromide (Cs<sub>3</sub>MnBr<sub>5</sub>) is easy to synthesize and has low toxicity and superior luminescent properties. However, most synthesis methods rely on liquid-phase reaction systems and cannot achieve highly efficient synthesis. High-energy ball milling is an efficient method and has enormous potential for industrial production. In this paper, this method is used to synthesize Cs<sub>3</sub>MnBr<sub>5</sub>, and then Cs/Mn ratio, ball milling time, and ligand usage are studied. Furthermore, a new phase transformation of all-inorganic Mn<sup>2+</sup> bromide is discovered, and the mechanism of high-energy ball milling is interpreted combining with phase transformation process. This article brings a new method to synthesis of all-inorganic Mn<sup>2+</sup> bromide, explains the mechanism of ball milling, and expands the phase transformation of all-inorganic Mn<sup>2+</sup> bromide.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"13 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139762849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhiguo Sun, Ye Wu, Hongliang Chen, Xiaoyun Wu, Yanmei Zhou, Shigang Han, Yan Luo, Haibo Zeng
Component doping is the fundamental topic for modulating the properties of semiconductor materials. The introduction of doping ions into lead halide perovskites (LHPs) can not only maintain the excellent photoelectric properties but also enhance the stability of LHPs in open air and thermal environments. However, due to the “self-purification” effect in crystallography, there is an inherent trend to pop doping ions out of LHPs lattice. In this work, it is confirmed that in Mn2+ doped LHPs nanocrystals (NCs) the discharge of Mn2+ will be accelerated at higher temperatures. It is also proved that even at room temperature, the dopants in LHPs NCs will also actively “migrate”, resulting in declined optical performance. Therefore, for cation alloying/doping LHPs NCs, the migration of doping ions in the material should be considered in addition to the intrinsic halide migration characteristics. This work will provide a benign reference for application of doped LHPs NCs.
{"title":"Self-Purification Affecting the Optical Performance of Mn-Doped Halide Perovskite Nanocrystals","authors":"Zhiguo Sun, Ye Wu, Hongliang Chen, Xiaoyun Wu, Yanmei Zhou, Shigang Han, Yan Luo, Haibo Zeng","doi":"10.1002/ppsc.202300167","DOIUrl":"https://doi.org/10.1002/ppsc.202300167","url":null,"abstract":"Component doping is the fundamental topic for modulating the properties of semiconductor materials. The introduction of doping ions into lead halide perovskites (LHPs) can not only maintain the excellent photoelectric properties but also enhance the stability of LHPs in open air and thermal environments. However, due to the “self-purification” effect in crystallography, there is an inherent trend to pop doping ions out of LHPs lattice. In this work, it is confirmed that in Mn<sup>2+</sup> doped LHPs nanocrystals (NCs) the discharge of Mn<sup>2+</sup> will be accelerated at higher temperatures. It is also proved that even at room temperature, the dopants in LHPs NCs will also actively “migrate”, resulting in declined optical performance. Therefore, for cation alloying/doping LHPs NCs, the migration of doping ions in the material should be considered in addition to the intrinsic halide migration characteristics. This work will provide a benign reference for application of doped LHPs NCs.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"213 Suppl 2 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139579697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Igor S. Sergeev, Elizaveta A. Maksimova, Ekaterina O. Moiseeva, Olga Yu. Griaznova, Sergei A. Perkov, Polina A. Demina, Valeriy D. Zaytsev, Yury A. Koksharov, Maxim A. Rider, Ilya A. Zavidovskiy, Polina G. Rudakovskaya, Roman I. Romanov, Boris N. Khlebtsov, Anna O. Orlova, Sergey M. Deyev, Dmitry A. Gorin
The development of nanozymes, artificial enzymes made from inorganic nanoparticles, is widely studied due to their affordability, durability, and strength. Gold nanoparticles (AuNPs) are employed to imitate peroxidase, glucose oxidase, lactate oxidase, superoxide dismutase, and catalase. The last one transforms intracellular hydrogen peroxide into molecular oxygen, whose deficiency is characteristic of the hypoxic tumor microenvironment. Thus, gold nanoparticles are thought to enhance the overall effectiveness of photodynamic therapy. However, the enzyme-like activity of nanoparticles rapidly decreases in biological media, due to the aggregation and formation of the so-called “protein corona”. In this study, polymeric submicrocapsules loaded with AuNPs and a photodynamic dye are fabricated via Layer-by-Layer (LbL) assembly. The enhancement of photodynamic treatment efficacy by in situ production of oxygen by the catalase-like effect of AuNPs is investigated. Polymeric capsules are thoroughly characterized in terms of physicochemical and catalytic properties, and as a proof of concept, their therapeutic potential is evaluated in vitro. Furthermore, encapsulated AuNPs shows significantly lower aggregation both upon storage and during the reaction course. The results shows that the polymer capsules, containing AuNPs and photodynamic dye, show significantly higher light-induced cytotoxicity in comparison to the individual photodynamic dye, suggesting a synergistic effect between the formation of molecular oxygen by catalase-like gold nanozymes and photodynamic action.
{"title":"Photoinduced Toxicity Caused by Gold Nanozymes and Photodynamic Dye Encapsulated in Submicron Polymer Shell","authors":"Igor S. Sergeev, Elizaveta A. Maksimova, Ekaterina O. Moiseeva, Olga Yu. Griaznova, Sergei A. Perkov, Polina A. Demina, Valeriy D. Zaytsev, Yury A. Koksharov, Maxim A. Rider, Ilya A. Zavidovskiy, Polina G. Rudakovskaya, Roman I. Romanov, Boris N. Khlebtsov, Anna O. Orlova, Sergey M. Deyev, Dmitry A. Gorin","doi":"10.1002/ppsc.202300149","DOIUrl":"https://doi.org/10.1002/ppsc.202300149","url":null,"abstract":"The development of nanozymes, artificial enzymes made from inorganic nanoparticles, is widely studied due to their affordability, durability, and strength. Gold nanoparticles (AuNPs) are employed to imitate peroxidase, glucose oxidase, lactate oxidase, superoxide dismutase, and catalase. The last one transforms intracellular hydrogen peroxide into molecular oxygen, whose deficiency is characteristic of the hypoxic tumor microenvironment. Thus, gold nanoparticles are thought to enhance the overall effectiveness of photodynamic therapy. However, the enzyme-like activity of nanoparticles rapidly decreases in biological media, due to the aggregation and formation of the so-called “protein corona”. In this study, polymeric submicrocapsules loaded with AuNPs and a photodynamic dye are fabricated via Layer-by-Layer (LbL) assembly. The enhancement of photodynamic treatment efficacy by in situ production of oxygen by the catalase-like effect of AuNPs is investigated. Polymeric capsules are thoroughly characterized in terms of physicochemical and catalytic properties, and as a proof of concept, their therapeutic potential is evaluated in vitro. Furthermore, encapsulated AuNPs shows significantly lower aggregation both upon storage and during the reaction course. The results shows that the polymer capsules, containing AuNPs and photodynamic dye, show significantly higher light-induced cytotoxicity in comparison to the individual photodynamic dye, suggesting a synergistic effect between the formation of molecular oxygen by catalase-like gold nanozymes and photodynamic action.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"50 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139579562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cover image provided courtesy of Tymish Y. Ohulchanskyy, Junle Qu, Anderson S. L. Gome, and co-workers.
封面图片由 Tymish Y. Ohulchanskyy、Junle Qu、Anderson S. L. Gome 及合作者提供。
{"title":"(Part. Part. Syst. Charact. 1/2024)","authors":"","doi":"10.1002/ppsc.202470025","DOIUrl":"https://doi.org/10.1002/ppsc.202470025","url":null,"abstract":"Cover image provided courtesy of Tymish Y. Ohulchanskyy, Junle Qu, Anderson S. L. Gome, and co-workers.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"7 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139557709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Florian Störmann, Toralf Roch, Andreas Lendlein, Christian Wischke
Polymer network materials are interesting alternatives to thermoplastic polymers. Here, the preparation of polymer capsules is investigated, which are made from poly(ε-caprolactone) (PCL) networks and are compartmentalized in a crosslinked PCL shell and a core that is suitable to enclose payloads of interest. Aided by microfluidic templating, PCL network capsules with a narrow size distribution (176 ± 5 µm) and thin shells (≈7.5 µm) are formed from 4-arm star-shaped 12 kDa PCL precursors by photoinitiator-free UV light-induced radical polymerization of methacrylate end-groups. FITC-BSA is encapsulated as a model protein. The physicochemical characterization of the capsules indicated a partial crosslinking of methacrylate endgroups into netpoints. Microscopy revealed a fraction of collapsed capsules that are discussed in the context of network stability and mechanical stress created at the capsule interfaces during solvent removal. The incubation of particles with human embryonic kidney (HEK) cells showed good cell compatibility, suggesting their potential use in biosciences and beyond.
{"title":"Microfluidic Templating and Initiator-Free Photocrosslinking of Protein-Loaded PCL Microcapsules","authors":"Florian Störmann, Toralf Roch, Andreas Lendlein, Christian Wischke","doi":"10.1002/ppsc.202300099","DOIUrl":"https://doi.org/10.1002/ppsc.202300099","url":null,"abstract":"Polymer network materials are interesting alternatives to thermoplastic polymers. Here, the preparation of polymer capsules is investigated, which are made from poly(ε-caprolactone) (PCL) networks and are compartmentalized in a crosslinked PCL shell and a core that is suitable to enclose payloads of interest. Aided by microfluidic templating, PCL network capsules with a narrow size distribution (176 ± 5 µm) and thin shells (≈7.5 µm) are formed from 4-arm star-shaped 12 kDa PCL precursors by photoinitiator-free UV light-induced radical polymerization of methacrylate end-groups. FITC-BSA is encapsulated as a model protein. The physicochemical characterization of the capsules indicated a partial crosslinking of methacrylate endgroups into netpoints. Microscopy revealed a fraction of collapsed capsules that are discussed in the context of network stability and mechanical stress created at the capsule interfaces during solvent removal. The incubation of particles with human embryonic kidney (HEK) cells showed good cell compatibility, suggesting their potential use in biosciences and beyond.","PeriodicalId":19903,"journal":{"name":"Particle & Particle Systems Characterization","volume":"17 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139501151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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