Pain Research & Management最新文献

Objective: To compare and evaluate the effect of ProTaper Ultimate root canal instrumentation on postoperative pain level of mandibular first molars showing symptomatic irreversible pulpitis and symptomatic apical periodontitis.

Methodology: Forty patients referred to root canal treatment of the mandibular first molar were randomly divided into two equal groups according to the rotary file system used in the chemomechanical preparation: ProTaper Ultimate (n = 20) and ProTaper Gold (n = 20). After evaluating the preoperative pain score using the visual analog scale, the root canal treatment was performed in a single visit using a standardized protocol by a single operator. Postoperatively, the pain scores were recorded at 24-, 72-h, and 7-day intervals. Statistical analysis was performed at a significance of 0.05.

Results: No significant difference was shown between the ProTaper Ultimate and the ProTaper Gold groups in the intensity of postoperative pain at all time intervals. The postoperative pain score was zero at 7 days postoperatively for both groups.

Conclusion: The ProTaper Ultimate files' effect on postoperative pain is equivalent to that of the ProTaper Gold files.

Clinical relevance: The ProTaper Ultimate files' effect on postoperative pain is equivalent to that of the ProTaper Gold files. ProTaper Ultimate and ProTaper Gold rotary file systems can be equally and safely used in single-visit root canal treatment.

Trial registration: ClinicalTrials.gov identifier: NCT05747183.

Background: In childhood, assessing the history of headaches in children can be challenging due to their age and the reliance on parental reports, which may sometimes lead to under/over-reporting of symptoms. This study utilized the ID Migraine questionnaire to evaluate the presence of headaches in a sample of children and examined the correlation between the children's responses and those of their mothers.

Methods: A cohort of children aged 10-12 years and their mothers administered the ID Migraine questionnaire separately, which included questions about the children's headaches.

Results: The cohort comprised 68 children (35 females and 33 males) aged 10-12 years. Within the last 3 months, 24/68 (35.3%) reported experiencing a history of headache episodes. Headache was reported by 16/35 females (45.7%) and 8/33 males (24.2%). Of the total, only 2/68 (2.95%) met two of the three criteria for potential migraine classification, 11/68 (16.1%) met at least one criterion, and 11 reported headaches but did not meet any criteria. Discrepancies between the children's and mother's responses occurred in 23/68 cases (33.8%), of which 14 (about 61%) disagreed about the occurrence of headaches in the past 3 months and 9 (about 49%) had inconsistencies in their responses to the Migraine ID items.

Conclusions: These results highlight the challenges of collecting headache data in children under 12 years of age. Notably, there is a discrepancy between children's and mothers' reports, with underreporting headaches reported by the other in nearly 60% of the conflicting cases. Additionally, the incidence of migraine observed in this sample was lower than what is commonly suggested in the literature.

Background: This study aims to identify sociodemographic factors associated with cannabis use for chronic pain management before and after COVID-19 was declared a pandemic. Furthermore, it seeks to compare cannabis use patterns in adults with and without chronic pain.

Methods: We analyzed US-based responses from the COVID-19 Cannabis Health Study, a cross-sectional online survey administered via REDCap between March 2020 and March 2022. All respondents were cannabis consumers in the past year. Cannabis use patterns and chronic pain were self-reported via the COVID-19 Cannabis Health Questionnaire. Statistical analysis included Chi-square tests, Fisher's exact tests, t-tests, and multivariable logistic regression with a two-tailed alpha of 0.05 for significance.

Results: Among 2243 participants, 50.3% consumed cannabis to manage chronic pain. Younger age (< 40 years; aOR: 3.20, 95% CI: 2.59-3.96), Hispanic/Latino ethnicity (aOR: 2.20, 95% CI: 1.56-3.05), and higher income levels (> $100,000 annually; aOR: 1.69, 95% CI: 1.25-2.29) were associated with higher odds of consuming cannabis to manage chronic pain. Participants using cannabis for chronic pain were more likely to use a CBD/THC ratio. The pandemic led to increased dosages and changes in consumption methods: 40.5% increased their cannabis dose, smoking as the primary method declined from 62.2% before the pandemic to 34.5% afterward, while edibles rose from 7.9% to 30.9%, and tinctures from 3.2% to 8.6%. Route changes varied with chronic pain status.

Conclusion: There was a shift from smoking to nonsmoking methods to manage chronic pain. Those who were younger and those of Hispanic/Latino ethnicity had higher odds of using cannabis for chronic pain.

Background: Active physiotherapy utilizes patient-centered, sensorimotor-integrated interventions to modulate central nervous system function. This randomized controlled trial (RCT) compared the efficacy of multimodal active physiotherapy (MAP) versus multimodal passive physiotherapy (MPP) in improving physical and mental health in chronic nonspecific neck pain (CNNP) patients.

Methods: This single-blind, stratified parallel-group RCT included 54 patients with CNNP. Participants were randomly assigned to the MAP or MPP group, both receiving 16 treatment sessions (60 min/session) over 8 weeks. Primary outcomes were pain intensity (Numeric Pain Rating Scale) and emotional status (Hospital Anxiety and Depression Scale). Secondary outcomes included patient-perceived change, pain modulation, insomnia symptoms, kinesiophobia, neck function, and mental health-related quality of life (QoL). Intention-to-treat analyses were performed.

Results: Postintervention, there were no significant group-time interactions in the primary outcomes (pain intensity, anxiety, and depression; all p > 0.05), despite significant within-group improvements from baseline (all p < 0.01). Analyses adjusted for covariates confirmed no between-group differences. For secondary outcomes, the MAP group demonstrated superior improvements compared to the MPP group in conditioned pain modulation, kinesiophobia, and mental health-related QoL; no other significant differences were observed between the groups.

Conclusion: In patients with CNNP, MAP and MPP result in comparable improvements in pain and emotional status; however, MAP demonstrates superior benefits relative to MPP in pain modulation, movement-related fear, and mental health-related QoL.

Trial registration: Chinese Registry of Clinical Trials: ChiCTR2500104619.

Background: Electroacupuncture (EA) has been widely applied in treating dysmenorrhea and autonomic dysfunction. Low-level laser acupuncture (LLLA), a noninvasive acupuncture, has been used clinically, but efficacy is uncertain. This study aimed to explore the efficacy of LLLA, EA, and sham-controlled LLLA on pain, heart rate variability (HRV) activity, and symptom improvement in dysmenorrhea with autonomic imbalance.

Method: In a randomized, controlled design, a total of 114 women with dysmenorrhea and autonomic imbalance were randomly allocated to three groups: sham LLLA, LLLA, and EA. The primary outcomes are pain (VAS), and HRV parameters, and the secondary outcomes are symptom assessment (verbal multidimensional scoring system), prostaglandin E, progesterone levels, and the SF-12 quality-of-life assessment.

Results: Contrast to the sham acupuncture, LLLA and EA effectively reconciled the pain and sympathetic/parasympathetic tone significantly, no matter the vagus or sympathetic deviated status (low or high LF/HF group). LLLA was superior to EA in terms of SDNN, RMMSD, and PNN50 (p < 0.001) in the low LF/HF group in intergroup analysis. For all participants' analysis, the effects of LLLA and EA were similar for pain assessment (VAS) and quality of life (SF-12) (p < 0.05). In proinflammatory cytokine measurement, EA showed a significant decrease in prostaglandin E2 (PGE2) levels (p = 0.022).

Conclusion: This pilot study showed both LLLA and EA effectively relieve dysmenorrhea without a placebo effect, LLLA is noninferior to EA in autonomic dysfunction, and the effect is even more prominent in low LF/HF status (a relatively lower energy status). Given its noninvasiveness, LLLA could be an alternative treatment and warrants further large-scale study.

Trial registration: ClinicalTrials.gov identifier: NCT04178226.

Radiofrequency and cryoneurolysis are promising options for managing chronic and acute pain. These minimally invasive techniques target nerve structures to alleviate pain in various conditions. This narrative review aims to provide an overview of the historical development, current techniques, applications, and existing evidence for radiofrequency and cryoneurolysis in pain management. While research is ongoing, evidence suggests their effectiveness in treating conditions like postmastectomy pain, phantom limb pain, radicular pain, and trigeminal neuralgia. However, their adoption in clinical guidelines varies, and they carry potential risks. Healthcare professionals should carefully consider the benefits, risks, and current evidence base when making treatment decisions.

Objectives: Calcaneal spur is an important cause of chronic pain that is resistant to conservative treatments and reduces quality of life. Nerve ablation techniques are widely used in chronic pain. This study aimed to investigate the short- and long-term effects of radiofrequency thermocoagulation (RFT) and intralesional cryoablation (CA) on pain management, functional limitation, and ankle function in patients with calcaneal spurs.

Materials and methods: This study included 71 patients aged between 28 and 52 years (body mass index, 22.3-31.1) who were receiving chronic pain treatment. The patients were evaluated pre- and postoperatively using the visual analog scale, functional limitation, activity limitation, and American Orthopedic Foot and Ankle Society score.

Results: VAS was measured as 1.2 ± 0.1 in the RFT group and 1.3 ± 0.2 in the CA group at 6 months. RFT yielded faster and more effective results in pain management and short-term functional improvement (p=0.00002), whereas CA was superior to the former in terms of ankle function in the long term (p=0.0001).

Conclusion: RFT and CA have different advantages. Thus, personalized treatment should be provided to each patient. Although our study was conducted retrospectively, prospective studies are needed to support our findings.

Background: Coccyx morphologic features have been found to be associated with coccydynia, while coccygeal anatomical data of patients with coccydynia is scarce. The purpose of this study is to evaluate the morphological and morphometric parameters of the sacrococcyx in patients experiencing coccydynia.

Methods: Radiographic examinations of the pelvis were conducted on a cohort of 244 patients diagnosed with coccydynia. Sacrococcygeal morphological features and morphometric parameters were documented and measured.

Results: The most prevalent coccyx type was Type II (33.1%), followed by Type III (28.1%), Type IV (21.5%), Type I (12%), and Type V (5.4%), respectively. Coccygeal sacralization was present approximately one-third of cases. Around a quarter of the subjects exhibited subluxation. Bony spicule was present in 22.3% individuals. Lateral deviation of the coccyx was present in roughly one-fifth of the patients. Sacral curvature index and sacrococcygeal angles were greater in males with coccydynia than in females, while the coccygeal curvature index was smaller in males. The straight length of the coccyx, coccygeal curved index, and sacrolumbar angle all showed an increase with age.

Conclusion: Patients with coccydynia usually showed a more ventrally curved coccyx. Bony spicule, coccygeal sacralization, and lateral deviation of the coccyx were common among coccydynia patients. Coccyx alignment tended to become straighter, and the sacrolumbar angle tended to increase with age. Individuals presenting with these aforementioned anatomical features appear to be predisposed to coccydynia.

Background: Empathy for pain is a complex psychological process that enables us to understand the feelings of others experiencing pain. Personal pain experiences may shape our empathetic responses, though the precise relationship between empathy for pain and pain perception is not fully understood.

Objective: This study investigates how firsthand pain experiences influence brain responses related to empathy for pain.

Methods: We recruited 26 participants who underwent either painful or nonpainful electrical stimulation. They were then shown static pictures of hands in painful and nonpainful situations and asked to report their subjective ratings of pain empathy. Electroencephalograph activity was recorded to analyze the neural basis of their experiences.

Results: Participants who experienced painful stimulation reported higher empathy levels when viewing painful images. Electroencephalograph data revealed that painful stimulation elicited larger N1 and P2 amplitudes at the Cz electrode compared to nonpainful stimulation. It also enhanced N2 amplitudes in the frontal-central region when viewing painful pictures. Nonpainful stimulation reduced the discriminatory ability of N2 for subsequent painful and nonpainful images. Correlation analysis showed that individuals with higher pain sensitivity had greater variation in P2 responses to painful and nonpainful stimuli but less variation in N2 responses related to pain empathy.

Conclusions: These findings suggest that experiencing pain directly may enhance brain responses to others' pain, thereby increasing levels of pain empathy. This enhancement may be influenced by individual pain sensitivity and is less pronounced in those with high pain sensitivity.

Background: Mitochondria play a crucial role in various cellular processes, and their dysfunction has been increasingly recognized as a significant factor in the pathophysiology of chronic pain. Despite growing interest in this area, a comprehensive bibliometric analysis of the research trends, key themes, and influential contributions in the study of mitochondria and pain has not been conducted. This study aims to fill this gap by providing a detailed overview of the research landscape from 2004 to 2024.

Methods: A comprehensive literature search was performed using the Web of Science Core Collection database to identify relevant studies published between January 1, 2004, and June 24, 2024. A total of 1995 articles were identified and included in the analysis. Bibliometric tools, including CiteSpace, VOSviewer, and RStudio, were employed to analyze and visualize data related to cocitation networks, keyword co-occurrence, and clustering patterns. The analysis focused on identifying research trends, key authors, influential journals, and emerging themes within the field.

Results: The analysis revealed a significant increase in research activity on mitochondria and pain, particularly after 2011, with the number of publications rising from 74 in 2015 to 171 in 2020, representing a 131% growth during this period. Key themes identified include mitochondrial dysfunction, oxidative stress, neuroinflammation, autophagy, and mitochondrial biogenesis. The United States, China, Germany, and the United Kingdom emerged as leading contributors to the field, with prominent institutions such as Harvard University and the University of California playing central roles in collaborative networks. Influential authors and foundational studies were identified through cocitation analysis, highlighting the interdisciplinary nature of the research.

Conclusion: This bibliometric analysis provides a comprehensive overview of the evolving research landscape in mitochondria and pain, highlighting key trends, influential contributions, and emerging research directions. The findings underscore the growing recognition of mitochondrial dysfunction as a critical factor in pain mechanisms and suggest that future research should focus on translating basic findings into clinical practice while expanding global collaborations.