Pain Research & Management最新文献

Background: Tension-type headache (TTH), a prevalent form of primary headache, has been linked to alterations in spinal biomechanics.

Objective: This study aimed to compare spinal posture, mobility, and muscle endurance between women with and without TTH.

Methods: This case-control study included 68 women aged 18-55 years with (n = 34, age = 20.51 ± 1.73 years, BMI = 22.03 ± 2.90 kg/m²) and without (n = 34, age = 19.91 ± 0.99 years, BMI = 21.38 ± 2.99 kg/ m²) TTH. Posture (craniovertebral angle) and mobility (range of motion) of the cervical region were evaluated with a goniometer and posture and mobility of the thoracic and lumbar and sacral regions in the sagittal plane were evaluated with the Spinal Mouse device (IDIAG M360, Fehraltorf, Switzerland), cervical region muscle endurance was evaluated with cervical flexion and extension endurance tests and the craniocervical flexion test, and trunk muscle endurance was evaluated with McGill's trunk muscle endurance tests and the Sahrmann test.

Results: Cervical flexion (95% CI: -1.38 to -0.40, d = 0.90, p ≤ 0.001) and extension (95% CI: -2.02 to -0.97, d = 1.50, p ≤ 0.001) mobility and cervical flexor (95% CI: -1.49 to -0.49, d = 0.99, p ≤ 0.001) and deep neck flexor muscle endurance (95% CI: -1.64 to -0.61, d = 1.13, p ≤ 0.001) scores were lower in women with TTH compared to the healthy controls. It was also observed that the thoracic angle (95% CI: 0.11 to 1.08, d = 0.60, p = 0.015) was higher in the sagittal plane and trunk flexor (95% CI: -1.33 to -0.35, d = 0.84, p = 0.001) and trunk right/left lateral flexor muscle endurance (95% CI: -1.75 to -0.73, d = 1.24, p ≤ 0.001)/(95% CI: -1.76 to -0.73, d = 1.25, p ≤ 0.001) and trunk core stability (p = 0.003) scores were lower.

Conclusion: Cervical mobility was less and cervical muscle endurance was lower in women with TTH, but their cervical postures were similar. It was also observed that thoracic angle was higher in sagittal plane and trunk muscle endurance was lower.

Advanced cancer continues to pose a substantial global challenge, with complex symptom burdens and limited therapeutic options. Traditional Chinese Medicine (TCM), grounded in holistic theory and the principles of syndrome differentiation, employs interventions such as herbal medicine, acupuncture, moxibustion, and acupoint-based therapies to address both the malignancy and the patient's overall functional status. Emerging evidence indicates that TCM may alleviate symptom clusters associated with advanced cancer, enhance quality of life, and potentially contribute to improved survival outcomes. This review synthesizes findings from the past decade on the role of TCM in advanced cancer care, with a focus on herbal decoctions, Chinese herbal injections, acupuncture-either alone or in combination with herbal therapy-moxibustion with adjuvant medication, and other external TCM modalities. Evidence is examined regarding their effects on cancer-related pain, fatigue, gastrointestinal dysfunction, chemotherapy- and radiotherapy-induced toxicities, and immune modulation. By consolidating current clinical and mechanistic insights, this review aims to inform future research and support the integration of evidence-based TCM approaches into contemporary oncology practice.

Objective: Trigeminal neuralgia (TN) is a debilitating disorder characterized by severe facial pain. While percutaneous balloon compression (PBC) is an effective surgical treatment for TN, recurrence remains a significant concern, with varying reported rates. The identification of factors that contribute to recurrence after PBC is critical for improving treatment outcomes. However, existing predictive models for recurrence have limitations in accuracy and generalizability. This study aims to explore the influencing factors of TN recurrence after PBC and to construct a TN recurrence risk prediction model.

Methods: The clinical data of 448 TN patients treated for PBC were retrospectively analyzed and divided into a modeling group (n = 317) and a validation group (n = 131) in a ratio of 7:3. Patients were divided into two groups based on whether they experienced recurrence or not. Risk prediction models were constructed using three machine learning methods: logistic regression, random forest, and XGBoost. The area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, and specificity were used to evaluate the model performance.

Results: Multivariate analysis showed that the duration of disease, pain type, balloon shape, compression time, and delayed disappearance of pain were influencing factors for TN recurrence after PBC, while facial numbness was a protective factor. All three predictive models exhibit high accuracy. In the modeling group, the AUC values for the logistic regression, random forest, and XGBoost models are 0.810, 0.824, and 0.816, respectively. Furthermore, the random forest model outperforms the other two models in terms of accuracy, sensitivity, and specificity. Additionally, external validation also demonstrates that the random forest model has good predictive value for TN after PBC (AUC = 0.835).

Conclusion: The random forest model showed excellent performance in predicting TN recurrence after PBC, providing a powerful reference for clinical prevention.

[This corrects the article DOI: 10.1155/prm/7873155.].

Disorders of the musculoskeletal system cover a broad spectrum of conditions that impact the muscles, skeletal structure, joints, tendons, and ligaments, leading to discomfort, swelling, and limited movement. Bee venom acupuncture (BVA), a practice commonly used in Asian countries, has been employed for a considerable time in traditional medicine systems to treat these disorders by utilizing bee venom and its main constituent, melittin. The purpose of this extensive evaluation on is to offer a detailed examination of the healing capabilities, modes of operation medical uses, and safety records of melittin and BVA in the treatment of different musculoskeletal disorders.

Purpose: This study aims to detect influential works and authors, collaboration patterns, the developmental trajectory, current hotspots, and research gaps by multiple-perspective bibliometric analyses on publications related to temporomandibular disorders in children and adolescents from 2000 to 2024.

Methods: All documents were obtained from the Web of Science Core Collection (WoSCC). Excel, VOSviewer, Pajek, SCImago Graphica, and CiteSpace software were utilized for visualized analyses of research trends, co-authorship (including authors, institutions, and countries), journals, keywords, and cited references.

Results: A total of 2208 articles and reviews were retrieved and extracted. Both annual publications and citations exhibited the trend of significant increases. Pedersen TK was the most productive author, while List T was the most cited. The co-author networks represented by Yang C exhibited independent activities and emerging trends. Aarhus University was the most productive institution. Malmo University was influential with the most citations. The United States of America was leading and majorly collaborative in this field. Most Asian countries demonstrated a lack of cooperation but growingly engaged. Journal of Oral Rehabilitation was the core journal. The keywords "diagnostic criteria" and "cone-beam computed tomography" were high in burst strength recently. The largest cluster of cited references was "juvenile idiopathic arthritis" (JIA).

Conclusions: Burst keywords and references showed that prevalences, the diagnostic criteria for temporomandibular disorders, temporomandibular joint involvement in JIA, contrast-enhanced magnetic resonance imaging, and psychosocial factors were hotspots in recent years. It is hoped that this study will favor both clinicians and researchers by recommending valuable works, guiding their future work priorities, and inspiring their potential collaborations.

Background: The aim of this review was to evaluate studies concerned with substances which can be used as biochemical biomarkers of migraine (MH). Current MH diagnosis is based on the clinical criteria provided by International Headache Society (IHS) in the third edition of International Classification of Headache Disorders from 2018. Biochemical biomarkers could be useful in more precise and differential diagnosis which is important for proper choice of treatment.

Methods: Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines (PRISMA) were applied. MEDLINE (via PubMed), Web of Science, and Embase databases were searched in the recent 5 years. Studies exclusively focused on MH and biochemical biomarkers in adults and children, which can be applied as diagnostic tools, were conducted.

Results: Finally, 31 researchers were assessed and discussed. Most of the presented studies were focused on calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase-activating peptide (PACAP), pentraxin 3 (PTX3), cytokines, and markers related to mitochondrial metabolism, making CGRP and PACAP possible diagnostic biomarkers. However, other agents have promising value.

Conclusion: Based on the available studies, there are no specific substances which could be proposed as potential, practical, and useful biomarkers in HD. However, a few agents could be promising. The standardization of methodology would help in further investigations. Panels of biomarkers, easily obtained from blood but also from saliva and urine, could be interesting purposes for research in future.

Objectives: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a refractory chronic pelvic pain disorder. In patients presenting with perineal pain, quality of life is severely compromised due to the lack of effective analgesic interventions. This study aimed to evaluate the efficacy and safety of pudendal nerve pulsed radiofrequency (PRF) for managing perineal pain in IC/BPS patients.

Methods: We conducted a retrospective analysis of 51 female IC/BPS patients who underwent pudendal nerve PRF treatment at Peking University People's Hospital between January 2020 and May 2024. Therapeutic outcomes were evaluated using validated metrics including the visual analog scale (VAS), interstitial cystitis problem index (ICPI) and symptom index (ICSI), hospital anxiety and depression scale (anxiety: HADS-A and depression: HADS-D), and pain catastrophizing scale (PCS) to comprehensively assess treatment efficacy on perineal pain and associated psychosocial comorbidities.

Results: The VAS score decreased from 8.0 (7.0, 9.0) preoperatively to 4.0 (2.0, 6.0) at 6 months postoperatively (p < 0.0001). Both ICPI and ICSI scores decreased from 14.0 (12.0, 15.5) and 15.0 (12.0, 18.0) preoperatively to 8.0 (5.5, 11.0) and 8.0 (6.0, 13.0) at 6 months postoperatively, respectively (p < 0.0001). HADS-A and HADS-D scores decreased from 8.0 (4.5, 12) and 7.0 (4.5, 11.5) preoperatively to 5 (2.5, 9) and 3.0 (1.5, 7.0) at 6 months postoperatively, respectively (p < 0.05). The PCS score decreased from 36.58 ± 10.93 preoperatively to 13.46 ± 6.80 at 6 months postoperatively (p < 0.0001). The outcomes of pudendal nerve diagnostic blocks showed positive correlations with postoperative improvements in VAS, ICPI, and ICSI at 6 months. A small number of patients experienced transient buttock puncture site pain and acute urinary retention postoperatively, all of which resolved spontaneously without serious adverse reactions.

Conclusions: Pudendal nerve PRF demonstrates significant therapeutic efficacy in managing perineal pain among patients with IC/BPS. The outcomes of pudendal nerve diagnostic blocks exhibit predictive value for the effectiveness of pudendal nerve PRF in alleviating IC/BPS-associated perineal pain.

Background: Rebound pain (RP) is an acute, burning, or dull-aching type of pain that occurs following the resolution of regional anesthesia. It is a common but understudied problem in orthopedic patients undergoing surgery under regional anesthesia. This study aimed to determine the prevalence and predictors of RP severity in patients undergoing orthopedic surgeries.

Methods: A cross-sectional study was conducted involving 364 patients who underwent orthopedic surgery and received regional anesthesia. To determine factors associated with the severity of RP, bivariable and multivariable ordinal logistic regression analyses were conducted. Both crude and adjusted odds ratios with their corresponding 95% confidence interval were calculated to determine the strength of association.

Result: The prevalence of RP after resolution of regional anesthesia was 70.9% (95% CI: 65.9-75.5). Among all participants, 30.2% experienced mild RP, 19.2% had moderate pain, and 21.4% reported severe RP. Age less than 60 years (AOR: 2.34, 95% CI: 1.38-3.95, and p :  0.001), ASA physical status III or above (AOR: 5.84, 95% CI: 2.17-15.69, and p < 0.001), and having moderate (AOR: 2.86, 95% CI: 1.21-6.78, and p : 0.017) and severe (AOR: 7.48, 95% CI: 4.09-13.68, and p < 0.001) preoperative pain were significantly associated with increased odds of RP. In contrast, premedication with intravenous dexamethasone (AOR: 0.24, 95% CI: 0.14-0.43, and p < 0.001) and using local anesthetic adjuvants (AOR: 0.05, 95% CI: 0.02-0.11, and p < 0.001) were significantly associated with reduced odds of severe RP.

Conclusion: Our study found a high incidence of RP following the resolution of regional anesthesia in patients undergoing orthopedic surgery. To reduce its incidence and severity, it is essential to effectively manage and alleviate preoperative pain, incorporate local anesthetic adjuvants into nerve block solutions, utilize intravenous dexamethasone, and incorporate multimodal analgesia before the resolution of regional anesthesia.

Background: Given the increasing volume of scientific research on orthodontic-related discomfort and pain (ORDP) in recent years and the scarcity of related quantitative analyses, this study aims to analyze the research hotspots and emerging trends of ORDP with the bibliometric method.

Materials and methods: A systematic search within the Web of Science Core Collection database was conducted on 30th April 2024. After manually screening and removing duplicate or irrelevant publications, we collected relevant studies for comprehensive bibliometric analysis, encompassing analyses of countries, institutions, authors, journals, documents, and keywords, which were performed using VOSviewer 1.6.19 and CiteSpace 5.7R5.

Results: A total of 970 publications were included in the bibliometric analysis. A significant upward trend in the annual publication output was observed, peaking in 2020. China (n = 120) has the highest publication output, representing 12.9% of the documents, while the United States has the highest citation count (2778). Sichuan University (n = 47), contributing 5.08% of all publications, accounts for the largest volume of literature in the ORDP research field. The American Journal of Orthodontics and Dentofacial Orthopedics (n = 91) was identified as the most productive journal in this domain. Furthermore, a comprehensive keyword analysis revealed five clusters for ORDP research and provided insights into the hotspots and trends. ORDP associated with invisible orthodontics, laser therapy to manage ORDP, and ORDP related to accelerated orthodontic tooth movement surgery are burgeoning areas of research interest.

Conclusion: This study reveals the global research distribution in the field of ORDP over time and across regions, highlighting key contributors across various dimensions. The field of ORDP has experienced significant growth, with emerging interests in invisible orthodontics, laser therapy for ORDP management, and accelerated orthodontic techniques. Further high-quality research is needed to explore personalized appliance selection, optimize innovative orthodontic technique processes, and establish specific protocols for promising management strategies such as low-level laser therapy.