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Epidemiology of respiratory syncytial virus within a New South Wales-based multi-centre health district between 2018 and 2024 in Australia 2018年至2024年澳大利亚新南威尔士州多中心卫生区内呼吸道合胞病毒的流行病学研究

IF 3 3区医学 Q1 PATHOLOGY

Pathology

Pub Date : 2025-08-29 DOI: 10.1016/j.pathol.2025.06.011

Zubair Akhtar , Adriana Notaras , Essa Tawfiq , Mohana Kunasekaran , C. Raina MacIntyre , William Rawlinson , Gregory J. Walker

Respiratory syncytial virus (RSV) epidemiology in Australia is unclear given recent advances in diagnostic testing, COVID-19 interventions, and under-recognition in older adults. Data are needed to inform new RSV vaccine use. We analysed laboratory data from all viral respiratory reverse transcription quantitative polymerase chain reaction (RT-qPCR) diagnostic tests conducted at New South Wales (NSW) Health Pathology in the South Eastern Sydney and Illawarra Health Service from 2018 to 2024. Panel and descriptive analyses were used to report annual RSV testing and detection by age group, care setting, and co-infection with other respiratory viruses using Stata v.18. Of 370,126 unique episodes tested for RSV, there were 13,293 (3.6%) detections. Public health measures for COVID-19 significantly impacted RSV circulation in 2020, with detections nearly absent in the winter season (June–August) and an off-season epidemic occurring in the summer. Annual testing and detection peaked in 2022 and was considerably higher than in pre-pandemic years (testing 6.3-fold and detection 3.4-fold higher than in 2019, respectively). Across the study period, incidence was highest in children aged <5 years (1,613 per 100,000 population). Among older adults (≥60 years of age), prevalence was 125 per 100,000. Testing was primarily performed in outpatients (71%), of which emergency departments were the most frequent care setting (49%). Of all detections, 2,713 (20.4%) had co-infections, with the most commonly co-detected viruses being rhinovirus (37%) and bocavirus (17%). RSV testing increased from 2022 due to expanded respiratory screening, RSV becoming a notifiable disease, and COVID-19 epidemics. Multiplex RT-qPCR testing increased RSV detection, but testing bias exists, with children tested more than adults. Continued surveillance across age groups is essential to assess the impact of new immunisation strategies.

鉴于最近在诊断检测、COVID-19干预措施和老年人认知不足方面取得的进展，澳大利亚呼吸道合胞病毒（RSV）的流行病学尚不清楚。需要数据来为新的RSV疫苗使用提供信息。我们分析了2018年至2024年在悉尼东南部新南威尔士州（NSW）健康病理学和伊拉瓦拉健康服务中心进行的所有病毒呼吸逆转录定量聚合酶链反应（RT-qPCR）诊断测试的实验室数据。使用Stata v.18进行小组分析和描述性分析，报告按年龄组、护理环境和合并感染其他呼吸道病毒进行年度RSV检测和检测。在37万126例RSV检测中，有13万293例（3.6%）被检测到。针对COVID-19的公共卫生措施在2020年显著影响了RSV的传播，冬季（6月至8月）几乎没有检测到RSV，而夏季出现了淡季流行。年度检测和检出率在2022年达到峰值，远高于大流行前的年份（检测率和检出率分别比2019年高6.3倍和3.4倍）。在整个研究期间，老年儿童的发病率最高

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引用次数: 0

A case of macro-aspartate aminotransferase after chemotherapy for locally advanced colorectal cancer 局部晚期结直肠癌化疗后大天冬氨酸转氨酶1例。

IF 3 3区医学 Q1 PATHOLOGY

Pathology

Pub Date : 2025-08-13 DOI: 10.1016/j.pathol.2025.06.006

Georgia Zeng , Sandhya Ramakrishna , Maria Charan , David Sullivan , Sarah Sutherland , Ken Liu

引用次数: 0

Rat bite fever diagnosed with clinical metagenomics 临床宏基因组学诊断鼠咬热。

IF 3 3区医学 Q1 PATHOLOGY

Pathology

Pub Date : 2025-08-13 DOI: 10.1016/j.pathol.2025.06.008

Sanmarié Schlebusch , Rikki M.A. Graham , Susan Moss , Amy V. Jennison , Stephen Boyle , Nathan Milne

引用次数: 0

Distribution of common clinical chemistry measurands in a healthy population: a resource for indirect reference interval studies 健康人群中常见临床化学指标的分布：间接参考区间研究的资源。

IF 3 3区医学 Q1 PATHOLOGY

Pathology

Pub Date : 2025-08-11 DOI: 10.1016/j.pathol.2025.06.007

Christopher-John L. Farrell , Gus Koerbin , Julia M. Potter , Peter E. Hickman

引用次数: 0

Primary lung ameloblastic carcinoma: an unreported primary lung tumour 原发性肺成釉细胞癌：一种未报道的原发性肺肿瘤。

IF 3 3区医学 Q1 PATHOLOGY

Pathology

Pub Date : 2025-08-06 DOI: 10.1016/j.pathol.2025.05.017

Mingfang Sun , Hongjiu Ren , Lin Fu , Jian Wang , Ping Yu , Hongtao Xu , Xuyong Lin

引用次数: 0

A challenging case of an epithelioid haemangioma of bone with novel FOS::ANKRD28 gene fusion 具有新的FOS::ANKRD28基因融合的骨上皮样血管瘤的一个具有挑战性的病例。

IF 3 3区医学 Q1 PATHOLOGY

Pathology

Pub Date : 2025-08-05 DOI: 10.1016/j.pathol.2025.06.005

Fleur Cordier , Liesbeth Ferdinande , Siebe Loontiens , Joni Van der Meulen , Jo Van Dorpe , David Creytens

引用次数: 0

A case of primary intestinal T-follicular helper cell lymphoma 原发性肠道t滤泡辅助细胞淋巴瘤1例。

IF 3 3区医学 Q1 PATHOLOGY

Pathology

Pub Date : 2025-07-29 DOI: 10.1016/j.pathol.2025.05.012

Reiji Muto , Hiroaki Miyoshi , Seiya Kato , Takahiro Mizutani , Noriyuki Saito , Koichi Ohshima

引用次数: 0

Micronodular perivascular epithelioid cell tumour of the appendix 阑尾小结节性血管周围上皮样细胞瘤。

IF 3 3区医学 Q1 PATHOLOGY

Pathology

Pub Date : 2025-07-29 DOI: 10.1016/j.pathol.2025.05.016

Yueh Lee , Meng-Fang Li , Po-Yen Kuo , Yueh-Hung Chou

引用次数: 0

T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is extensively expressed in the microenvironment of nodular lymphocyte-predominant Hodgkin lymphoma and T-cell-/histiocyte-rich large B-cell lymphoma 具有Ig和ITIM结构域的t细胞免疫受体（TIGIT）在结节性淋巴细胞为主的霍奇金淋巴瘤和富含t细胞/组织细胞的大b细胞淋巴瘤的微环境中广泛表达。

IF 3 3区医学 Q1 PATHOLOGY

Pathology

Pub Date : 2025-07-29 DOI: 10.1016/j.pathol.2025.05.013

Georgia Karpathiou , Somaia Chokoud , Mousa Mobarki , Michel Péoc'h

T-cell immunoreceptor with immunoglobulin (Ig) and immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT) is a molecule involved in the immune escape of tumour cells and is a target of immunotherapy. Recently, TIGIT has gained attention as a crucial player in the tumour microenvironment (TME) of lymphomas. TIGIT immunohistochemical expression has not been thoroughly studied in nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) and T-cell-/histiocyte-rich large B-cell lymphoma (THRLBCL). We studied TIGIT's immunohistochemical expression in 27 whole-lymph-node sections from 19 patients diagnosed with NLPHL and eight patients diagnosed with THRLBCL. TIGIT was consistently expressed in the TME of all lymphomas, exhibiting strong membranous staining. The TME expression ranged from 40% to 90% (median 70%). Rosettes around tumour cells were common in 23 (85.1%) cases. TIGIT was expressed by tumour cells in four cases (14.8%). NLPHL and THRLBCL harbour extensive TIGIT expression in their microenvironment, often in the form of peritumoural rosettes; some express TIGIT in tumor cells. Despite a small cohort, our results suggest that patients may benefit from TIGIT inhibition.

具有免疫球蛋白（Ig）和酪氨酸基抑制基序（ITIM）结构域（TIGIT）的t细胞免疫受体是参与肿瘤细胞免疫逃逸的分子，是免疫治疗的靶点。最近，TIGIT作为淋巴瘤肿瘤微环境（TME）的重要参与者而受到关注。TIGIT在结节淋巴细胞为主的霍奇金淋巴瘤（NLPHL）和富含t细胞/组织细胞的大b细胞淋巴瘤（THRLBCL）中的免疫组织化学表达尚未得到充分研究。我们研究了19例NLPHL患者和8例THRLBCL患者的27个全淋巴结切片中TIGIT的免疫组织化学表达。TIGIT在所有淋巴瘤的TME中一致表达，呈现强烈的膜性染色。TME的表达范围为40% ~ 90%（中位数为70%）。23例（85.1%）肿瘤细胞周围常见玫瑰花结。4例（14.8%）肿瘤细胞表达TIGIT。NLPHL和THRLBCL在其微环境中广泛表达TIGIT，通常以肿瘤周围玫瑰花的形式表达；一些在肿瘤细胞中表达TIGIT。尽管是一个小队列，我们的结果表明患者可能受益于TIGIT抑制。

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引用次数: 0

Signet-ring pleomorphic plasma cells: a potential diagnostic pitfall in multiple myeloma 印戒多形性浆细胞：多发性骨髓瘤的一个潜在诊断缺陷。

IF 3 3区医学 Q1 PATHOLOGY

Pathology

Pub Date : 2025-07-29 DOI: 10.1016/j.pathol.2025.05.014

Badr AbdullGaffar , Mohamed Burney

引用次数: 0

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