Pub Date : 2025-02-01DOI: 10.1016/j.pathol.2024.12.038
Dhamidhu Eratne , Cherie Chang , Kruti Patel , Jeff Smith , Qiao-Xin Li , Colin Masters , Dennis Velakoulis
{"title":"Biomarkers in neuropsychiatric disorders: neurofilament light and other simple blood tests to improve timely and accurate diagnosis of dementia and distinction from primary psychiatric disorders?","authors":"Dhamidhu Eratne , Cherie Chang , Kruti Patel , Jeff Smith , Qiao-Xin Li , Colin Masters , Dennis Velakoulis","doi":"10.1016/j.pathol.2024.12.038","DOIUrl":"10.1016/j.pathol.2024.12.038","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 ","pages":"Pages S8-S9"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.pathol.2024.12.409
Tony Huynh
{"title":"Dynamic endocrine testing in children – can any laboratory be involved?","authors":"Tony Huynh","doi":"10.1016/j.pathol.2024.12.409","DOIUrl":"10.1016/j.pathol.2024.12.409","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 ","pages":"Page S9"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01Epub Date: 2024-09-25DOI: 10.1016/j.pathol.2024.07.005
Yanyan Chen, Shuyuan Xiao, Qiu Zhao
Behçet disease (BD), enterocolic lymphocytic phlebitis (ELP), idiopathic myointimal hyperplasia of mesenteric veins (IMHMV), and mesenteric arteriovenous dysplasia/vasculopathy (MAVD/V) are rare vascular diseases (VDs) that cause bowel ischaemia, often presenting with a histological pattern resembling chronic enteritis, leading to diagnostic confusion with Crohn disease (CD). In this retrospective study, we compared the clinical and pathological characteristics of these VDs with those of CD. The study cohort comprised 13 patients misdiagnosed with CD but later identified as having VDs, including five, three, two, and three patients with BD, ELP, IMHMV, and MAVD/V, respectively. Moreover, 15 patients diagnosed with CD served as the control group. Data on disease history, patient demographics, symptoms and signs, endoscopic findings, clinical diagnosis, and follow-up status were collected, and the histological features of VDs were compared with those of CD. Despite substantial overlap in clinical and pathological characteristics between VDs and CD, several histological features were helpful in differentiating the two conditions. Intestinal stenosis, multisegmental disease, transmural inflammation, inflammatory polyps, submucosal lymphangiectasia, intramural abscesses, and epithelioid granulomas were significantly more frequent in patients with CD (p<0.001). In contrast, toxic ischaemic changes and vascular lesions were significantly more frequent in patients with VDs (p<0.001). The location of diseased vessels varied widely in patients with VDs, whereas vascular changes were limited to areas with more severe inflammation in those with CD. Furthermore, inflammatory cells within diseased vessels exhibited a polarised distribution in cases of CD, manifesting in two distinct patterns: pattern 1, where the inflammatory cells are densely populated in the outer layer of the vessel wall and sparsely populated in the inner layer; pattern 2, where the inflammatory cells are densely populated on the side with the ulcer and sparsely populated on the opposite side. Vascular occlusion, which was observed in all patients with VDs, was rare in those with CD. In summary, VDs and CD can be distinguished through careful histological analysis, particularly focusing on characteristics of vascular changes, in combination with medical history.
贝赫切特病（BD）、肠结肠淋巴细胞性静脉炎（ELP）、特发性肠系膜静脉肌层增生症（IMHMV）和肠系膜动静脉发育不良/血管病变（MAVD/V）是导致肠缺血的罕见血管疾病（VD），通常表现为类似慢性肠炎的组织学模式，导致与克罗恩病（CD）的诊断混淆。在这项回顾性研究中，我们比较了这些血管性疾病与克罗恩病的临床和病理特征。研究队列中包括 13 名被误诊为 CD 但后来被确认为 VD 的患者，其中包括分别患有 BD、ELP、IMHMV 和 MAVD/V 的 5 名、3 名、2 名和 3 名患者。此外，15 名确诊为 CD 的患者作为对照组。研究人员收集了有关病史、患者人口统计学特征、症状和体征、内窥镜检查结果、临床诊断和随访情况的数据，并将VD的组织学特征与CD的组织学特征进行了比较。尽管VDs和CD在临床和病理特征上有大量重叠，但有几个组织学特征有助于区分这两种疾病。肠道狭窄、多节段疾病、跨壁炎症、炎性息肉、粘膜下淋巴管扩张、壁内脓肿和上皮样肉芽肿在 CD 患者中的发病率明显更高（P＜0.05）。
{"title":"Intestinal vascular diseases misdiagnosed as Crohn disease: analysis of 13 cases.","authors":"Yanyan Chen, Shuyuan Xiao, Qiu Zhao","doi":"10.1016/j.pathol.2024.07.005","DOIUrl":"10.1016/j.pathol.2024.07.005","url":null,"abstract":"<p><p>Behçet disease (BD), enterocolic lymphocytic phlebitis (ELP), idiopathic myointimal hyperplasia of mesenteric veins (IMHMV), and mesenteric arteriovenous dysplasia/vasculopathy (MAVD/V) are rare vascular diseases (VDs) that cause bowel ischaemia, often presenting with a histological pattern resembling chronic enteritis, leading to diagnostic confusion with Crohn disease (CD). In this retrospective study, we compared the clinical and pathological characteristics of these VDs with those of CD. The study cohort comprised 13 patients misdiagnosed with CD but later identified as having VDs, including five, three, two, and three patients with BD, ELP, IMHMV, and MAVD/V, respectively. Moreover, 15 patients diagnosed with CD served as the control group. Data on disease history, patient demographics, symptoms and signs, endoscopic findings, clinical diagnosis, and follow-up status were collected, and the histological features of VDs were compared with those of CD. Despite substantial overlap in clinical and pathological characteristics between VDs and CD, several histological features were helpful in differentiating the two conditions. Intestinal stenosis, multisegmental disease, transmural inflammation, inflammatory polyps, submucosal lymphangiectasia, intramural abscesses, and epithelioid granulomas were significantly more frequent in patients with CD (p<0.001). In contrast, toxic ischaemic changes and vascular lesions were significantly more frequent in patients with VDs (p<0.001). The location of diseased vessels varied widely in patients with VDs, whereas vascular changes were limited to areas with more severe inflammation in those with CD. Furthermore, inflammatory cells within diseased vessels exhibited a polarised distribution in cases of CD, manifesting in two distinct patterns: pattern 1, where the inflammatory cells are densely populated in the outer layer of the vessel wall and sparsely populated in the inner layer; pattern 2, where the inflammatory cells are densely populated on the side with the ulcer and sparsely populated on the opposite side. Vascular occlusion, which was observed in all patients with VDs, was rare in those with CD. In summary, VDs and CD can be distinguished through careful histological analysis, particularly focusing on characteristics of vascular changes, in combination with medical history.</p>","PeriodicalId":19915,"journal":{"name":"Pathology","volume":" ","pages":"57-64"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01Epub Date: 2024-09-30DOI: 10.1016/j.pathol.2024.07.007
Timothy Wade, Pranav Dorwal, Richard J Harvey, Jonathan Williamson, Tina Baillie, Alexandra Allende
{"title":"Recurrent DEK::AFF2 fusion squamous cell carcinoma: prompts for diagnosis of this emerging distinct entity.","authors":"Timothy Wade, Pranav Dorwal, Richard J Harvey, Jonathan Williamson, Tina Baillie, Alexandra Allende","doi":"10.1016/j.pathol.2024.07.007","DOIUrl":"10.1016/j.pathol.2024.07.007","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":" ","pages":"131-134"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01Epub Date: 2024-10-15DOI: 10.1016/j.pathol.2024.08.006
David Patton, Andrew Carr, Winnie W Y Tong, Fiona Maclean, Julia P Low
{"title":"Epstein-Barr virus-associated smooth muscle tumour following immunosuppression for systemic lupus erythematosus.","authors":"David Patton, Andrew Carr, Winnie W Y Tong, Fiona Maclean, Julia P Low","doi":"10.1016/j.pathol.2024.08.006","DOIUrl":"10.1016/j.pathol.2024.08.006","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":" ","pages":"126-128"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.pathol.2024.12.104
Emily Powley , Steven Lane , Cyriac Abraham
{"title":"De novo AML in the setting of treatment naïve CLL","authors":"Emily Powley , Steven Lane , Cyriac Abraham","doi":"10.1016/j.pathol.2024.12.104","DOIUrl":"10.1016/j.pathol.2024.12.104","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 ","pages":"Page S21"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.pathol.2024.12.023
Melinda Lerwill
{"title":"Papillary neoplasms of the breast","authors":"Melinda Lerwill","doi":"10.1016/j.pathol.2024.12.023","DOIUrl":"10.1016/j.pathol.2024.12.023","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 ","pages":"Page S5"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143093006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.pathol.2024.12.052
Maaike Moller
{"title":"Forensic medical responses to sexual violence as international crimes","authors":"Maaike Moller","doi":"10.1016/j.pathol.2024.12.052","DOIUrl":"10.1016/j.pathol.2024.12.052","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 ","pages":"Page S11"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143093033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.pathol.2024.12.083
Jessica M. Clarke , Melanie Galea , Luke Hesson
{"title":"Investigation of atypical profiles on a targeted CFTR assay can expand diagnostic yield","authors":"Jessica M. Clarke , Melanie Galea , Luke Hesson","doi":"10.1016/j.pathol.2024.12.083","DOIUrl":"10.1016/j.pathol.2024.12.083","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 ","pages":"Page S16"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.pathol.2024.12.097
Ilias Goranitis
{"title":"Valuation in translation of genomic medicine technologies","authors":"Ilias Goranitis","doi":"10.1016/j.pathol.2024.12.097","DOIUrl":"10.1016/j.pathol.2024.12.097","url":null,"abstract":"","PeriodicalId":19915,"journal":{"name":"Pathology","volume":"57 ","pages":"Page S19"},"PeriodicalIF":3.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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