Catastrophic outburst floods from natural-dam failures are among Earth's most powerful landscape-sculpting agents, yet their long-term frequency and relationship with orbital-scale climate cycles remain poorly constrained. The Yarlung Tsangpo River in the eastern Himalaya provides an unparalleled setting to resolve this, but research has largely focused on Holocene events. Here, we extend this record into the deep past, presenting a comprehensive geomorphological and geochronological reconstruction of outburst floods extending back to ∼259 ka. We identify at least six distinct, high-magnitude outburst flood episodes based on field evidence of giant bars. Hydraulic modeling shows these events had colossal peak discharges ranging from 0.2 to 2.1 × 106 m3/s. Robust single-grain post-infrared infrared stimulated luminescence (pIRIR) dating establishes a chronology securely linked to distinct clusters: an early series associated with Marine Isotope Stage (MIS) 8 and its termination (∼259 ka, <242 ka, and ∼ 232 ka), followed by major events at ∼115 ka (MIS 5d), ∼18 ka (MIS 2), and ∼ 11 ka (Latest Pleistocene). Crucially, the stratigraphic tight coupling of flood deposits with immediately overlying paleosols provides physical evidence that these catastrophic failures were synchronous with rapid climatic transitions. This confirms a systematic causal mechanism: the advance of valley glaciers during cold stages (e.g., MIS 8, MIS 6, MIS 2) repeatedly dammed the river at the Gyaca Gorge, with catastrophic failure triggered during subsequent periods of climatic amelioration. Our findings reveal that glacial-interglacial climate cyclicity has exerted a first-order control on the pacing of the most extreme geomorphic events, fundamentally shaping the long-term landscape evolution of the world's highest mountain range.
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