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Survey of socio-demographic prevalence, risk factors and clinical characterization of tuberculosis in Nishtar Hospital Multan. 木尔坦Nishtar医院结核病的社会人口患病率、危险因素和临床特征调查。
Pub Date : 2016-01-27 DOI: 10.22200/PJPR.201618-14
Sana Sharif, N. M. Ranjha, A. Majeed, G. Abbas, Muhammad Ajmal, S. Hassan, Basma Aftab, Musaddique Hussain, R. Rehman
Tuberculosis is a worldwide health problem affecting one third of world’s population and Pakistan is no exception. In this study, we used a structured and close-ended questionnaire to collect data about socio-demographic prevalence of tuberculosis, its risk factors, multiple drug resistance tuberculosis and clinical characterization of tuberculosis from Nishtar Hospital Multan, Pakistan. Tuberculosis is an infectious disease, affecting young people and females more commonly in Pakistan. Urbanization, illiteracy, poverty, family history of TB, associated immunosuppressive disorders, smoking and alcohol consumption are major drivers of tuberculosis. Multiple drug resistance tuberculosis is also an emerging problem.
结核病是一个影响世界三分之一人口的全球性健康问题,巴基斯坦也不例外。在这项研究中,我们使用结构化和封闭式问卷来收集有关巴基斯坦木尔坦Nishtar医院结核病的社会人口患病率、危险因素、多重耐药结核病和结核病临床特征的数据。结核病是一种传染病,在巴基斯坦更常见于年轻人和女性。城市化、文盲、贫困、结核病家族史、相关免疫抑制疾病、吸烟和饮酒是结核病的主要驱动因素。耐多药结核病也是一个新出现的问题。
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引用次数: 4
Screening of hepatoprotective effect of methanolic extract of Solanum nigrum against paracetamol 龙葵甲醇提取物对扑热息痛的保肝作用筛选
Pub Date : 2015-06-01 DOI: 10.22200/PJPR.2015270-77
A. Mumtaz, Muhammad Zabta Ch., Syed Nisar Hussain Shah
Solanum nigrum (SN) commonly known as “Makoo” frequently available in most of the areas of Pakistan, is well reputed in the indigenous system of medicine for its medicinal use in liver disorders. The present study was aimed to evaluate its traditional use in liver diseases using in-vivo model of rabbits. The crude methanolic extract of the aerial parts of the Solanum nigrum  (SN.CEA) was investigated for its hepatocurative and hepatoprotective activities in paracetamol intoxicated (2g/Kg) rabbits. Rabbits were divided into three groups, normal control (saline treated) hepatotoxic control (paracetamol treated) and remaining one was hepatotoxic treated with the SN.CEA (400 mg/kg) for 6-12 days. Similarly, for hepatoprotective effect rabbits were divided in 3 groups; one serving as control another as hepatotoxic and last one as treated with SN.CAE. Group 2 nd and 3 rd were intoxicated with paracetamol at 6 th day of the treatment with SN.CEA. Increased serum transaminases (sGOT and sGPT) and alkaline phosphatase (ALP) levels along with raised sleeping span and blood clotting time were observed in hepatotoxic rabbits. In both cases (hepatocuration and hepatoprotection) SN.CEA caused significantly reduction in all the above serum markers for liver functioning and caused significant reduction in the sleeping time of treated rabbits vs hepatotoxic untreated group. These data suggests that the presence of hepatocurative and hepatoprotective constituents in Solanum nigrium rationalizes its medicinal use in liver dysfunction
黑茄(Solanum nigrum, SN)俗称“Makoo”,在巴基斯坦大部分地区都能买到,在当地医学体系中因其治疗肝脏疾病而享有良好声誉。本研究旨在通过兔体内模型评价其在肝脏疾病中的传统应用。以对乙酰氨基酚(2g/Kg)中毒家兔为研究对象,研究了茄油(sna . cea)气相部位粗甲醇提取物对肝脏的保护作用。将家兔分为正常对照组(生理盐水组)、肝毒性对照组(扑热息痛组)和肝毒性对照组(SN组)。CEA (400 mg/kg), 6-12天。同样,为观察其肝保护作用,将家兔分为3组;一组作为对照,另一组作为肝毒性,最后一组作为SN.CAE治疗。第2组和第3组在SN.CEA治疗第6天给予扑热息痛。肝毒性家兔血清转氨酶(sGOT、sGPT)和碱性磷酸酶(ALP)水平升高,睡眠时间和凝血时间延长。在这两种情况下(肝闭合和肝保护)。与肝毒性未处理组相比,CEA显著降低了上述血清肝功能指标,并显著减少了治疗兔的睡眠时间。这些数据表明,茄草中存在的肝治疗和肝保护成分使其在肝功能障碍中的药用合理化
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引用次数: 4
Comparison of Flurbiprofen Tablets Available In Pakistani Market and Their Absorption Studies 巴基斯坦市场上氟比洛芬片的比较及吸收研究
Pub Date : 2015-06-01 DOI: 10.22200/PJPR.2015262-69
Muhammad Hanif, V. Chaurasiya, Muqeet Wahid, M. Basharat, S. Naz, S. Mirza, Qurat-ul-ain Aslam, M. Tariq, A. Butt
Abstract The aim of this present work was to compare different parameters of various brands of flurbiprofen tablets collected from different retail pharmacies in the local market of Pakistan. Four brands A, B, C and D were tested for weight variation, hardness, friability, disintegration dissolution, HPLC assay and in vitro absorption studies in rabbit skin, stomach and intestine by using the prepacked Column RT 250-4.6 Purospher® STAR RP-18 end capped (5 µm) and acetonitrile, phosphate buffer (pH 3.7) as mobile phase in the ratio of 1:1. Flurbiprofen was detected at 265 nm at the flow rate of 1 ml/min. Brand B was considered as reference. Similarity factor ( f 2 ) of brand B and C and brand B & D was found to be 61 and 51 and dissimilarity factors ( f 1 ) values were 5 and 9 respectively in same dissolution medium. Model dependent methods First order, Hixon crowell and Weibull model were used. The method was found to be sensitive and linear in the range of 10 to 700 ppm with 0.999 coefficient of correlation. Everted sac absorption studies of selected formulation showed 50% of drug absorption from stomach in first 3 hours, 21% through intestine and very negligible through skin .
摘要本研究的目的是比较巴基斯坦当地不同零售药店收集的不同品牌氟比洛芬片的不同参数。采用预包装柱RT 250-4.6 Purospher®STAR RP-18端帽(5µm),以乙腈、磷酸缓冲液(pH 3.7)为流动相,以1:1的比例,测定A、B、C、D四个品牌在兔皮肤、胃和肠中的重量变化、硬度、脆性、崩解度、HPLC测定和体外吸收研究。氟比洛芬在265 nm检测,流速为1 ml/min。B品牌作为参考。在同一溶出介质中,B、C和B、D的相似因子(f2)分别为61和51,不同因子(f1)分别为5和9。模型依赖方法采用一阶Hixon crowell和Weibull模型。结果表明,该方法在10 ~ 700 ppm范围内具有良好的灵敏度和线性关系,相关系数为0.999。所选制剂的外翻囊吸收研究表明,前3小时药物从胃吸收50%,通过肠道吸收21%,通过皮肤吸收几乎可以忽略。
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引用次数: 0
A Review of Frequency and Pattern of Diseases among Patients in Pakistan 巴基斯坦患者疾病的频率和模式综述
Pub Date : 2015-06-01 DOI: 10.22200/PJPR.2015292-94
Saima Khanum, Hafsa Hina, Muhammad Hanif
An important aspect of human life is a sound health. The chance of illness reduces with better health. It is proved that level of mortality, morbidity and infertility lowers with healthy life style. In healthy population the rate of diseases is minimum. Better health also improves school children attendance due to fewer leaves as comparative in illness.  For better development of human resource investment should be done on health departments of the country (World Bank, 1993). In Pakistan health care system has been improved by view of physical infrastructure and manpower growth in both public and private setup. However, health care delivery system is not fulfilling the needs of fast growing population of the country. Maternal and infants mortality rate is still high as compared to its other neighboring countries. The conditions would be better by increasing budget allocation to the health sector.
人类生活的一个重要方面是健康。健康状况越好,患病的机会就越少。事实证明,健康的生活方式降低了死亡率、发病率和不孕症水平。在健康人群中,发病率最低。健康状况的改善也提高了学生的出勤率,因为与疾病相比,请假的人数减少了。为了更好地发展人力资源,应对该国的卫生部门进行投资(世界银行,1993年)。在巴基斯坦,由于公共和私营机构的物质基础设施和人力增长,医疗保健系统得到了改善。然而,卫生保健提供系统不能满足该国快速增长的人口的需求。与其他邻国相比,产妇和婴儿死亡率仍然很高。如果增加对卫生部门的预算拨款,情况将会好转。
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引用次数: 0
Phytochemical screening of different extracts of Kalanchoe laciniata 龙葵不同提取物的植物化学筛选
Pub Date : 2015-06-01 DOI: 10.22200/PJPR.2015258-61
M. Manan, Liaqat Hussain, H. Ijaz, Bushra Nawaz, M. Hanif
Alkaloids, tannins, saponins, steroids, terpenoids and flavonoids distribution in n-hexane and aqueous-methanolicextract of kalanchoelaciniata was assessed and compared. The present study was carried out to study the phytochemical constituents of Kalanchoe laciniata . Aqueous-methanol and n-hexane were the solvents used for the extraction of the plant. Phytochemical analysis was carried out on both of these extracts, indicated that n-hexane extract constitutes tannins, terpenoids on the other hand aqueous-methanolic extract contains saponins, tannins, terpenoids, flavonoids, glycosides  and anthraquinones.
比较了水甲醇浸提液和正己烷浸提液中生物碱、单宁、皂苷、甾体、萜类和黄酮类化合物的分布。本研究主要研究了白桦的植物化学成分。以水-甲醇和正己烷为萃取溶剂。对两种提取物进行了植物化学分析,表明正己烷提取物主要由单宁、萜类组成,而水甲醇提取物主要由皂苷、单宁、萜类、黄酮类、苷类和蒽醌类组成。
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引用次数: 2
Phytochemical and pharmacological studies of Leptadenia pyrotechnica 火蕨的植物化学和药理研究
Pub Date : 2015-06-01 DOI: 10.22200/PJPR.2015278-85
Fahim Ullah, M. Uzair, B. Chaudhry, Z. Zafar
Traditional healing systems which mainly rely on plants, herbs and shrubs always played a vital role in the global health system. As the natural products are usually less toxic, have less side effects and easily available so the demand for plant base drugs is increasing. This ultimately provides a base for the drug research. Leptadenia pyrotechnica is a shrub found in desert areas belonging to the family Asclepiadaceae. It is an important medicinal plant and all parts of the plant are used in folk medicines. The present article is having a detail about phytochemistry, pharmacological activities of the plant and isolated constituents with their structures. The updated information included in this article will be helpful for the researchers.
主要依靠植物、草药和灌木的传统治疗系统在全球卫生系统中一直发挥着至关重要的作用。由于天然产物通常毒性较小,副作用较小且易于获得,因此对植物基药物的需求正在增加。这最终为药物研究提供了基础。火蕨是一种发现于沙漠地区的灌木,属于火蕨科。它是一种重要的药用植物,它的所有部分都被用于民间药物。本文详细介绍了该植物的植物化学、药理活性、分离成分及其结构。本文所包含的最新信息将对研究人员有所帮助。
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引用次数: 5
Diffusion coefficient, porosity measurement, dynamic and equilibrium swelling studies of Acrylic acid/Polyvinyl alcohol (AA/PVA) hydrogels 丙烯酸/聚乙烯醇(AA/PVA)水凝胶的扩散系数、孔隙率测量、动态和平衡膨胀研究
Pub Date : 2015-06-01 DOI: 10.22200/PJPR.2015248-57
N. M. Ranjha, Muhammad Hanif, Zunaira Afzal, Ghulam Abbas
Objective of the present work was to synthesize hydrogels of acrylic acid/polyvinyl alcohol (AA/PVA) by free radical polymerization by using glutaradehyde (GA) as crosslinkers. The hydrogels were evaluated for swelling, diffusion coefficient and network parameters like the average molecular weight between crosslink’s, polymer volume fraction in swollen state, number of repeating units between crosslinks and crosslinking density by using Flory-Huggins theory. It was found that the degree of swelling of AA/PVA hydrogels increases greatly within the pH range 5-7. The gel fraction and porosity increased by increasing the concentration of AA or PVA. Increase in degree of crosslinking, decreased the porosity and inverse was observed in gel fraction. Selected samples were loaded with metoprolol tartrate. Drug release was studied in USP hydrochloric acid solution of pH 1.2 and phosphate buffer solutions of pH 5.5 and 7.5. Various kinetics models like zero order, first order, Higuchi and Peppas model were used for in vitro kinetic studies. The results showed that the drug release followed concentration dependent effect (First order kinetics) with non-Fickian diffusion. FTIR and SEM used to study the structure, crystallinity, compatibility, thermal stability and morphology of prepared and drug loaded hydrogels respectively.
以戊二醛为交联剂,采用自由基聚合法制备丙烯酸/聚乙烯醇(AA/PVA)水凝胶。采用Flory-Huggins理论对水凝胶的溶胀、扩散系数、交联平均分子量、膨胀态聚合物体积分数、交联重复单元数、交联密度等网络参数进行评价。结果表明,在pH值为5 ~ 7的范围内,AA/PVA水凝胶的溶胀程度大大增加。随着AA和PVA浓度的增加,凝胶分数和孔隙率均有所增加。交联度增加,孔隙度降低,凝胶分数相反。所选样品以酒石酸美托洛尔装药。在pH为1.2的USP盐酸溶液和pH为5.5和7.5的磷酸盐缓冲溶液中研究药物释放。采用零阶、一阶、Higuchi、Peppas等动力学模型进行体外动力学研究。结果表明,药物释放具有浓度依赖效应(一级动力学),具有非菲克扩散。利用FTIR和SEM分别研究了制备的水凝胶和载药水凝胶的结构、结晶度、相容性、热稳定性和形貌。
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引用次数: 9
Advances in the Management of Cerebral Vascular Disease 脑血管病的治疗进展
Pub Date : 2015-06-01 DOI: 10.22200/PJPR.2015286-91
M. Qadir, H. Kanwal
A cerebral vascular disease occurred with the arteries of brain due to the less supply of blood.  Stroke is mostly caused by cerebral vascular disease and it is also a common cause of vascular dementia due to reduced oxygen supply and blood flow to the brain. In industrialized countries, neurologic disability is most frequently caused by cerebeovascular disease. Individuals with cardiovascular disease, diabetes and high blood pressure etc are at higher possibility for cerebral vascular disease. After malignancy and heart disease, cerebral vascular disease is the third leading of death and estimated that an average 500,000 new stroke occurred in each year. Advance techniques such as Carotid Endarterectomy, Magnetic resonance imaging, Angiography and Single photon emission computed tomography etc are used for management of cerebral vascular disease.
脑动脉因供血不足而发生脑血管疾病。中风主要是由脑血管疾病引起的,由于大脑供氧和血流量减少,中风也是血管性痴呆的常见原因。在工业化国家,神经系统残疾最常由脑血管疾病引起。患有心血管疾病、糖尿病、高血压等的人患脑血管疾病的可能性较高。继恶性肿瘤和心脏病之后,脑血管疾病是第三大死亡原因,据估计,每年平均有50万例新发中风。颈动脉内膜切除术、磁共振成像、血管造影和单光子发射计算机断层扫描等先进技术被用于脑血管疾病的治疗。
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引用次数: 0
Microspheres a potential carrier for drugs 微球是药物的潜在载体
Pub Date : 2015-01-01 DOI: 10.22200/PJPR.2015119-24
A. Majeed, Muhammad Rizwan Khan, N. M. Ranjha, Muhammad Hanif, Syed Hussain, Muqeet Wahid, Faisal Usman
Microparticles are one of the recent controlled release dosage form, compressed in the form of tablets or filled in capsules. In this review different methods of preparations and their effects on physical properties i.e. Size, shape and porosity which can be controlled by ingredients used or process variables and characterization will be discussed. Future dimensions of these dosage forms are numerous when it comes to its application in drug delivery and to overcome issues associated with new drug molecule in drug discovery process.
微颗粒是最近的控释剂型之一,可压缩成片剂或胶囊。在这篇综述中,将讨论不同的制备方法及其对物理性质的影响,即尺寸、形状和孔隙度,这些可以由所用的成分或工艺变量控制。这些剂型在药物传递中的应用以及在药物发现过程中克服与新药物分子相关的问题时,未来的维度是众多的。
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引用次数: 1
Awareness about Homoeopathy among University students 大学生对顺势疗法的认知
Pub Date : 2015-01-01 DOI: 10.22200/PJPR.2015138-40
M. Qadir, F. Hussain, Muahammad Hanif, Muqeet Wahid
Homoeopathy is an alternative medical treatment developed in Germany by Dr. Samuel Hahnemann. He proposed two theories about homoeopathy: “Like cures Like” and the “Law of Minimum Dose”. The objective for this study was to evaluate the level of awareness about homoeopathic medical treatment among university students. A Questionnaire was developed containing five basic questions related to homeopathic medical sciences. 500 students from Bahauddin Zakariya University, Multan, Pakistan were selected for this study. The only 5% university students used homoeopathic medicines in their live. From our research, it was concluded that awareness about homoeopathy among students is not up to the mark. While, homoeopathy awareness may make the world a healthier, and happier place.
顺势疗法是由塞缪尔·哈内曼博士在德国开发的一种替代疗法。他提出了两种顺势疗法理论:“以毒攻毒”和“最小剂量定律”。本研究的目的是评估大学生对顺势疗法医疗的认知水平。一份调查问卷包含五个与顺势疗法医学科学相关的基本问题。本研究选取了来自巴基斯坦木尔坦Bahauddin Zakariya大学的500名学生。只有5%的大学生在他们的生活中使用顺势疗法药物。从我们的研究中得出结论,学生对顺势疗法的认识还没有达到标准。然而,顺势疗法的意识可能会让世界变得更健康、更快乐。
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引用次数: 0
期刊
Pakistan Journal of Pharmaceutical Research
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