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Patenting trends by Mexican pharmaceutical companies. 墨西哥制药公司的专利申请趋势。
IF 1.3 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2023-11-01 Epub Date: 2024-01-10 DOI: 10.4155/ppa-2023-0029
Luis Villafaña-Diaz, Juan C Perez-Garcia, Diana Barron-Villaverde, Martin Perez-Santos

Aim: the activity of patent claims by Mexican pharmaceutical companies is unknown. Objective: analyse the trend in patents of Mexican pharmaceutical companies. Method: a search for patents was carried out in the patent database of the Mexican Institute of Industrial Property, using the list of Mexican pharmaceutical companies belonging to the Mexican Association of Pharmaceutical Research Industries, and the codes A61K, A61P and C07 of the International Patent Classification. Results: the leading companies in patent applications were Liomont, Senosiain and RIMSA; however, Mexican pharmaceutical companies claim very few patents, only 266 patent applications in the period 2000-2020, with a technological factor with a value of zero, and a commercial factor of little value. Conclusion: Mexican pharmaceutical companies lack a robust patent system, without growth, and with a low percentage of patents with high commercial value.

目的:墨西哥制药公司的专利申请活动尚不为人知。目的:分析墨西哥制药公司的专利趋势。方法:在墨西哥工业产权局的专利数据库中,利用墨西哥制药研究工业协会所属的墨西哥制药公司名单和国际专利分类代码 A61K、A61P 和 C07 进行专利检索。结果:专利申请量最大的公司是利奥蒙德、塞诺西亚因和 RIMSA;然而,墨西哥制药公司申请的专利很少,2000-2020 年间仅有 266 项专利申请,技术因素值为零,商业因素值很小。结论:墨西哥制药公司缺乏健全的专利制度,没有增长,商业价值高的专利比例低。
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引用次数: 0
Lipid-based mesoporous silica nanoparticles: a paradigm shift in management of pancreatic cancer. 基于脂质的介孔二氧化硅纳米粒子:胰腺癌治疗模式的转变。
IF 1.3 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2023-11-01 Epub Date: 2024-01-12 DOI: 10.4155/ppa-2023-0024
Kiran Kumar Bellapu, Ramesh Joga, Bharthi R Kannan, Sravani Yerram, Priya Varpe, Tejaswini Mergu, Pavan Y Vasu, Saurabh Srivastava, Sandeep Kumar

Pancreatic adenocarcinoma, a devastating disease, has the worst cancer prognosis in humans. It often develops resistance to common chemotherapy medications, such as gemcitabine, taxol and 5-fluorouracil. The dense stroma limits therapeutic efficacy in treating this disease. Low or limited drug loading capacity is another problem with current chemotherapeutic agents. There is a need to develop novel approaches to overcome these issues. Hence, an innovative approach has been proposed to co-deliver both hydrophilic (Gemcitabine) and hydrophobic (Paclitaxel) drugs in a single carrier using lipid bilayer-mesoporous silica nanoparticles (LB-MSNP). MSNPs offer effective drug delivery due to their superior bioavailability and physicochemical properties. Further, in order to achieve clinical translation and regulatory approval, toxicity and biodegradability of MSNPs must be resolved.

胰腺腺癌是一种毁灭性疾病,是人类预后最差的癌症。它常常对吉西他滨、紫杉醇和 5-氟尿嘧啶等常见化疗药物产生抗药性。致密的基质限制了治疗这种疾病的疗效。药物负荷能力低或有限是目前化疗药物的另一个问题。需要开发新的方法来克服这些问题。因此,有人提出了一种创新方法,利用脂质双分子层-介孔二氧化硅纳米颗粒(LB-MSNP)在单一载体中同时递送亲水性药物(吉西他滨)和疏水性药物(紫杉醇)。MSNP 具有优异的生物利用度和理化特性,可提供有效的药物输送。此外,为了实现临床转化和监管审批,必须解决 MSNP 的毒性和生物降解性问题。
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引用次数: 0
Prominence of bioresponsive DNA nanococoons in tackling post-surgery cancer recurrence. 生物反应性DNA纳米茧在治疗术后癌症复发中的突出作用。
IF 1.3 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2023-09-01 Epub Date: 2023-11-20 DOI: 10.4155/ppa-2023-0013
Sravani Yerram, Ramesh Joga, Pooja Shende, Priya Varpe, Kiran Kumar Bellapu, Sandeep Kumar

Post-surgery cancer recurrence is one of the reasons for increased cancer cases. The effective usage of the enhanced permeability and retention effect of a nanocarrier infused with the bioresponsive release mechanism of checkpoint inhibitors (aPD1 and aCTLA4) can become a boon to mankind. DNA nanococoons (DNCs) comprising cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG-ODNs) with potent immunostimulatory effects can significantly enhance anti-cancer activity. Triglycerylmonostearate (TGMS) with enzymatic cleavage potential at the wound sites of tumor resection, upon caging with restriction enzyme (HhaI) followed by attaching to DNCs, makes the immunotherapy bioresponsive. Hhal-TGMS-DNCs-aPD1 triggered by the inflammation at the wound site undergoes enzymatic cleavage, releases the restriction enzyme, converts DNCs to CpG ODNs sequentially and with sustained aPD1 release exerts an appreciable anti-cancer effect.

术后癌症复发是癌症病例增加的原因之一。有效利用注入检查点抑制剂(aPD1和aCTLA4)生物反应性释放机制的纳米载体的增强渗透性和滞留效应,可以成为人类的福音。含有胞嘧啶-硫代磷酸酯-鸟嘌呤寡聚脱氧核苷酸(CpG-ODNs)的DNA纳米cocoons (dnc)具有较强的免疫刺激作用,可以显著增强抗癌活性。甘油三酯单硬脂酸酯(TGMS)在肿瘤切除的伤口部位具有酶切电位,在用限制性内切酶(HhaI)笼化后附着在dnc上,使免疫治疗具有生物反应性。伤口部位炎症触发的hhal - tgms - dnc -aPD1经过酶裂解,释放限制性内切酶,将dnc依次转化为CpG ODNs,并持续释放aPD1,具有明显的抗癌作用。
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引用次数: 0
Steroid sulfatase inhibitors and sulfated C19 steroids for proteotoxicity-related diseases: a patent spotlight. 类固醇磺化酶抑制剂和硫酸C19类固醇治疗蛋白质毒性相关疾病:专利焦点
IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2023-09-01 Epub Date: 2023-11-20 DOI: 10.4155/ppa-2023-0010
Rami A Al-Horani

Aging and proteotoxicity go hand in hand. Inhibiting proteotoxicity has been proposed to extend lifespan. This invention describes a new strategy to limit proteotoxicity and to extend the lifespan. Loss of function of sul-2, the Caenorhabditis elegans steroid sulfatase, elevates the pool of sulfated steroid hormones, increases longevity and ameliorates protein aggregation diseases. The present invention provides a group of molecules for use in the prevention of aging-associated proteotoxicity caused by protein aggregation diseases and/or to increase the lifespan of a eukaryotic organism. These molecules are either steroid sulfatase inhibitors or sulfated C19 steroids, both of which reproduce the phenotype of sul-2 mutants. One particular representative example is STX-64. Potential applications of the claims have been demonstrated in animal models of Parkinson's disease, Huntington's disease and Alzheimer's disease.

衰老和蛋白质毒性是密切相关的。抑制蛋白质毒性被认为可以延长寿命。本发明描述了一种限制蛋白质毒性和延长寿命的新策略。秀丽隐杆线虫类固醇硫酸酯酶sul2功能的丧失,增加了硫酸类固醇激素的数量,延长了寿命,改善了蛋白质聚集性疾病。本发明提供了一组分子,用于预防由蛋白质聚集疾病引起的与衰老相关的蛋白质毒性和/或增加真核生物的寿命。这些分子要么是类固醇硫酸酯酶抑制剂,要么是硫酸C19类固醇,两者都能产生硫-2突变体的表型。一个典型的例子是STX-64。这些说法的潜在应用已经在帕金森病、亨廷顿病和阿尔茨海默病的动物模型中得到证实。
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引用次数: 0
Recent patents in the treatment and prevention of leishmaniasis. 治疗和预防利什曼病的最新专利。
IF 1.3 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2023-09-01 Epub Date: 2023-12-08 DOI: 10.4155/ppa-2023-0022
Sukhbir K Shahid

Leishmaniasis, a neglected tropical disease, is caused by protozoal parasites of the genus Leishmania. Clinical manifestations vary from asymptomatic to lethal grade depending on the type of the disease. The currently available antileishmanial drugs suffer from considerable limitations. There is a dire need for better and safer drugs and/or vaccines to eradicate this disease. There are enormous developments ongoing in this field. Newer combinations of existing drugs and newer drugs targeting these intracellular parasites as well as their vectors are being tried to control the disease. Attempts to develop vaccines to enhance the immunity of the patient have shown some promise. This article is a peep into the recent patent developments in this field.

利什曼病是一种被忽视的热带疾病,由利什曼属原生动物寄生虫引起。临床表现因疾病类型而异,从无症状到致命程度不等。目前可用的抗利什曼病药物存在相当大的局限性。我们迫切需要更好、更安全的药物和/或疫苗来根除这种疾病。这一领域正在取得巨大进展。人们正在尝试将现有药物和针对这些细胞内寄生虫及其载体的新药组合起来,以控制这种疾病。开发疫苗以增强患者免疫力的尝试也已初见成效。本文将对这一领域的最新专利进展进行介绍。
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引用次数: 0
Patent highlights February-March 2023. 专利亮点2023年2月至3月。
IF 1.3 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2023-09-01 Epub Date: 2023-11-20 DOI: 10.4155/ppa-2023-0023
Hermann Am Mucke

A snapshot of noteworthy recent developments in the patent literature of relevance to pharmaceutical and medical research and development.

与制药和医学研究与开发相关的专利文献中值得注意的最新发展概况。
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引用次数: 0
Drug repurposing of rimantadine for treatment of cancer. 金刚乙胺治疗癌症的药物再利用。
IF 1.3 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2023-09-01 Epub Date: 2023-11-20 DOI: 10.4155/ppa-2023-0019
Nemesio Villa-Ruano, Vianey Marin-Cevada, Gabriela Sanchez-Esgua, Luis Villafaña-Diaz, Martin Perez-Santos

Repurposing of approved drugs allows strong savings in time and investment. Rimantadine is an FDA-approved drug for prevention and treatment of influenza A infection. Patent US2021330605 describes the use of rimantadine, an adamantane derivative, for the treatment of melanoma, breast cancer and head and neck squamous cell carcinoma. Rimantadine inhibited proliferation of cell lines of melanoma, breast cancer, and head and neck squamous cell carcinoma, increased the survival of mice injected with cancer cell lines and restores the expression of MHC class I. Rimantadine has the potential to be used successfully in the treatment of head and neck squamous cell carcinoma.

重新利用已批准的药物可以大大节省时间和投资。金刚乙胺是fda批准的预防和治疗甲型流感感染的药物。专利US2021330605描述了金刚烷衍生物金刚乙胺用于治疗黑色素瘤、乳腺癌和头颈部鳞状细胞癌的用途。金刚乙胺抑制黑色素瘤、乳腺癌和头颈部鳞状细胞癌细胞系的增殖,增加注射癌细胞的小鼠的存活率,恢复MHC i类的表达。金刚乙胺有可能成功用于头颈部鳞状细胞癌的治疗。
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引用次数: 0
Patent highlights December 2022-January 2023. 专利亮点2022年12月至2023年1月。
IF 1.3 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2023-07-01 Epub Date: 2023-10-06 DOI: 10.4155/ppa-2023-0016
Hermann Am Mucke
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引用次数: 0
Recent patent-based review on the role of three-dimensional printing technology in pharmaceutical and biomedical applications. 关于三维打印技术在制药和生物医学应用中的作用的最新专利综述。
IF 1.3 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2023-07-01 Epub Date: 2023-10-26 DOI: 10.4155/ppa-2023-0018
Palak Rani, Vikas Yadav, Parijat Pandey, Kiran Yadav

Three-dimensional printing (3DP) is emerging as an innovative manufacturing technology for biomedical and pharmaceutical applications, since the US FDA approval of Spritam as a 3D-printed drug. In the present review, we have highlighted the potential benefits of 3DP technology in healthcare, such as the ability to create patient-specific medical devices and implants, as well as the possibility of on-demand production of drugs and personalized dosage forms. We have further discussed future research to optimize 3DP processes and materials for pharmaceutical and biomedical applications. Cohesively, we have put forward the current state of active patents and applications related to 3DP technology in the healthcare and pharmaceutical industries including hearing aids, prostheses, medical devices and drug-delivery systems.

自从美国食品药品监督管理局批准Spritam作为3D打印药物以来,三维打印(3DP)正成为生物医学和制药应用的一种创新制造技术。在本综述中,我们强调了3DP技术在医疗保健中的潜在优势,例如创建患者专用医疗设备和植入物的能力,以及按需生产药物和个性化剂型的可能性。我们进一步讨论了未来优化3DP工艺和材料用于制药和生物医学应用的研究。我们共同提出了3DP技术在医疗保健和制药行业的活跃专利和应用现状,包括助听器、假肢、医疗器械和药物输送系统。
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引用次数: 0
Therapeutic charisma of imidazo [2,1-b] [1,3,4]-thiadiazole analogues: a patent review. 咪唑 [2,1-b] [1,3,4]- 噻二唑类似物的治疗魅力:专利回顾。
IF 1.3 Q3 PHARMACOLOGY & PHARMACY Pub Date : 2023-07-01 Epub Date: 2023-09-06 DOI: 10.4155/ppa-2023-0006
Anuradha Mehra, Rekha Sangwan, Aryan Mehra, Shivani Sharma, Pankaj Wadhwa, Amit Mittal

Imidazothiadiazole was discovered around the 1950s era, containing an imidazole ring fused to a thiadiazole ring. Imidazothiadiazole exhibit versatile pharmacological properties including anticonvulsant, cardiotonic, anti-inflammatory, diuretic, antifungal, antibacterial and anticancer. Despite of the being discovered in 1950s, the imidazothiadiazole derivatives are unable to being processed to clinical trials because of lack of bioavailability, efficacy and cytotoxicity. The recent patent literature focused on structural modification of imidazothiadiazole core to overcome these problems. This review limelight a disease-centric perspective on patented imidazothiadiazole from 2015-2023 and to understand their mechanism of action in related diseases. The relevant granted patent applications were located using patent databases, Google Patents, USPTO, EPO, WIPO, Espacenet and Lens.

咪唑噻二唑是在 20 世纪 50 年代左右发现的,含有一个咪唑环和一个噻二唑环。咪唑噻二唑具有抗惊厥、强心、消炎、利尿、抗真菌、抗菌和抗癌等多种药理特性。尽管咪唑噻二唑衍生物早在 20 世纪 50 年代就已被发现,但由于缺乏生物利用度、药效和细胞毒性,一直未能进入临床试验阶段。最近的专利文献主要集中在对咪唑噻二唑核心进行结构改造,以克服这些问题。本综述从疾病为中心的角度对2015-2023年的咪唑噻二唑专利进行分析,并了解其在相关疾病中的作用机制。相关已授权专利申请是通过专利数据库、谷歌专利、美国专利商标局、欧洲专利局、世界知识产权组织、Espacenet 和 Lens 查找的。
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引用次数: 0
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Pharmaceutical patent analyst
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