Pub Date : 2025-01-17DOI: 10.1542/peds.2024-068028
Elena Dingle,Jonathan H Pelletier,Michael L Forbes,Prabi Rajbhandari
OBJECTIVEThe 2021 American Academy of Pediatrics clinical practice guideline (CPG) for well-appearing febrile infants aims to promote evidence-based care, reduce practice variability, enhance care quality, and optimize cost. We aimed to examine the trends in resource utilization and cost associated with the evaluation and management of febrile infants aged 8 to 60 days before and after the CPG's publication.METHODSWe performed a retrospective cross-sectional study using the Pediatric Health Information Systems Database, covering the periods of August 2019 to July 2021 (pre-CPG) and August 2021 to July 2023 (post-CPG). We analyzed the use of antibiotics, acyclovir, laboratory studies, lumbar punctures (LPs), and hospitalizations before and after the CPG publication.RESULTSWe identified 33 736 encounters (12 220 pre-CPG and 21 516 post-CPG). After the CPG, there was a decrease in hospitalization (42.6% vs 34.7%, -7.9% [-9.0% to -6.8%]), antibiotic and acyclovir administration (41.9% vs 33.1%, -8.8% [-9.9% to -7.7%]; 9.7% vs 7.3%, -2.4% [-3.1% to -1.8%]), and LP (31.7% vs 21.8%, -9.9% [-10.9% to -8.9%]). Conversely, the use of C-reactive protein (23.7% vs 32.3%, 8.6% [7.6% to 9.5%]) and procalcitonin (40.1% vs 64.5%, 24.4% [23.3% to 25.5%]) increased. Cost remained unchanged. Age-stratified analysis revealed a significant reduction in hospitalization, antibiotic use, and LP in infants aged older than 22 days, whereas infants younger than 28 days experienced a slight increase in delayed diagnosis of bacteremia and sepsis after the CPG.CONCLUSIONSAfter the CPG, hospitalization, antimicrobial use, and LPs decreased in infants aged older than 22 days, indicating that the CPG may be effective in reducing resource utilization. There was a slight increase in delayed diagnosis of bacteremia and sepsis in infants younger than 28 days.
目的2021 年美国儿科学会针对表现良好的发热婴儿的临床实践指南(CPG)旨在促进循证护理、减少实践变异、提高护理质量并优化成本。我们旨在研究 CPG 发布前后,与 8 到 60 天发热婴儿评估和管理相关的资源利用和成本趋势。方法 我们利用儿科健康信息系统数据库进行了一项回顾性横断面研究,研究时间跨度为 2019 年 8 月到 2021 年 7 月(CPG 发布前)和 2021 年 8 月到 2023 年 7 月(CPG 发布后)。我们分析了 CPG 发布前后抗生素、阿昔洛韦、实验室检查、腰椎穿刺 (LP) 和住院的使用情况。CPG 发布后,住院率(42.6% vs 34.7%,-7.9% [-9.0% to -6.8%])、抗生素和阿昔洛韦用药率(41.9% vs 33.1%,-8.8% [-9.9% to -7.7%];9.7% vs 7.3%,-2.4% [-3.1% to -1.8%] )和 LP(31.7% vs 21.8%,-9.9% [-10.9% to -8.9%])均有所下降。相反,C 反应蛋白(23.7% 对 32.3%,8.6% [7.6% 至 9.5%])和降钙素原(40.1% 对 64.5%,24.4% [23.3% 至 25.5%])的使用率则有所上升。费用保持不变。年龄分层分析表明,采用 CPG 后,22 天以上婴儿的住院率、抗生素使用率和 LP 显著下降,而 28 天以下婴儿的菌血症和败血症延迟诊断率略有上升。28 天以下婴儿的菌血症和败血症延迟诊断率略有上升。
{"title":"Resource Utilization and Cost in Management of Febrile Infants After the 2021 Clinical Guideline.","authors":"Elena Dingle,Jonathan H Pelletier,Michael L Forbes,Prabi Rajbhandari","doi":"10.1542/peds.2024-068028","DOIUrl":"https://doi.org/10.1542/peds.2024-068028","url":null,"abstract":"OBJECTIVEThe 2021 American Academy of Pediatrics clinical practice guideline (CPG) for well-appearing febrile infants aims to promote evidence-based care, reduce practice variability, enhance care quality, and optimize cost. We aimed to examine the trends in resource utilization and cost associated with the evaluation and management of febrile infants aged 8 to 60 days before and after the CPG's publication.METHODSWe performed a retrospective cross-sectional study using the Pediatric Health Information Systems Database, covering the periods of August 2019 to July 2021 (pre-CPG) and August 2021 to July 2023 (post-CPG). We analyzed the use of antibiotics, acyclovir, laboratory studies, lumbar punctures (LPs), and hospitalizations before and after the CPG publication.RESULTSWe identified 33 736 encounters (12 220 pre-CPG and 21 516 post-CPG). After the CPG, there was a decrease in hospitalization (42.6% vs 34.7%, -7.9% [-9.0% to -6.8%]), antibiotic and acyclovir administration (41.9% vs 33.1%, -8.8% [-9.9% to -7.7%]; 9.7% vs 7.3%, -2.4% [-3.1% to -1.8%]), and LP (31.7% vs 21.8%, -9.9% [-10.9% to -8.9%]). Conversely, the use of C-reactive protein (23.7% vs 32.3%, 8.6% [7.6% to 9.5%]) and procalcitonin (40.1% vs 64.5%, 24.4% [23.3% to 25.5%]) increased. Cost remained unchanged. Age-stratified analysis revealed a significant reduction in hospitalization, antibiotic use, and LP in infants aged older than 22 days, whereas infants younger than 28 days experienced a slight increase in delayed diagnosis of bacteremia and sepsis after the CPG.CONCLUSIONSAfter the CPG, hospitalization, antimicrobial use, and LPs decreased in infants aged older than 22 days, indicating that the CPG may be effective in reducing resource utilization. There was a slight increase in delayed diagnosis of bacteremia and sepsis in infants younger than 28 days.","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":"55 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-17DOI: 10.1542/peds.2024-068699
Sarah Friebert,Eduardo A Trujillo Rivera,Justin N Baker,Jessica D Thompkins,Daniel Grossoehme,Jennifer Needle,Maureen E Lyon
BACKGROUND AND OBJECTIVETo evaluate the efficacy of Family-Centered Advance Care Planning for Teens With Cancer (FACE-TC) on adolescents' quality of life.METHODSA clinical trial randomized adolescent-family dyads at a 2:1 ratio to either FACE-TC or control. FACE-TC dyads received 3 weekly 60-minute sessions: Lyon Pediatric Advance Care Planning Survey; Next Steps: Respecting Choices; and Five Wishes. Generalized mixed-effect models evaluated efficacy at 3, 6, and 12 months after intervention measured by FACIT-SP-Ex-V4 (meaning/peace, faith) and PROMIS pediatric (anxiety; depressive symptoms; pain interference, fatigue). Fisher exact tests assessed decisional support and preparedness.RESULTSAdolescents (n = 126) were mean age 17 years, 57% female, and 79% white. No significant differences were found between groups for faith or meaning/peace. At 12 months after intervention compared to control, FACE-TC increased anxiety (mean ratio 1.14; CI 1.04-1.25), depressive symptoms (mean ratio 1.12; CI 1.02-1.22), and pain interference (mean ratio 1.10; CI 1.00-1.20), but not at 3 or 6 months. FACE-TC increased fatigue at 3 months (mean ratio 1.13; CI 1.02-1.26), but not at 6 or 12 months. Compared to control, adolescents participating in FACE-TC agreed that "I feel prepared for the future" (76% vs 94%) and "I feel we are now on the same page" (76% vs 94%) at 3 months, but not at 12 months.CONCLUSIONSThere were no significant differences in quality of life between groups until 1 year, except for fatigue. FACE-TC had late effects, increasing adolescents' anxiety, depressive symptoms, and pain interference. Reassessment at 1 year is clinically important.
{"title":"Pediatric Advance Care Planning and Adolescent Preparedness and Quality of Life: An RCT.","authors":"Sarah Friebert,Eduardo A Trujillo Rivera,Justin N Baker,Jessica D Thompkins,Daniel Grossoehme,Jennifer Needle,Maureen E Lyon","doi":"10.1542/peds.2024-068699","DOIUrl":"https://doi.org/10.1542/peds.2024-068699","url":null,"abstract":"BACKGROUND AND OBJECTIVETo evaluate the efficacy of Family-Centered Advance Care Planning for Teens With Cancer (FACE-TC) on adolescents' quality of life.METHODSA clinical trial randomized adolescent-family dyads at a 2:1 ratio to either FACE-TC or control. FACE-TC dyads received 3 weekly 60-minute sessions: Lyon Pediatric Advance Care Planning Survey; Next Steps: Respecting Choices; and Five Wishes. Generalized mixed-effect models evaluated efficacy at 3, 6, and 12 months after intervention measured by FACIT-SP-Ex-V4 (meaning/peace, faith) and PROMIS pediatric (anxiety; depressive symptoms; pain interference, fatigue). Fisher exact tests assessed decisional support and preparedness.RESULTSAdolescents (n = 126) were mean age 17 years, 57% female, and 79% white. No significant differences were found between groups for faith or meaning/peace. At 12 months after intervention compared to control, FACE-TC increased anxiety (mean ratio 1.14; CI 1.04-1.25), depressive symptoms (mean ratio 1.12; CI 1.02-1.22), and pain interference (mean ratio 1.10; CI 1.00-1.20), but not at 3 or 6 months. FACE-TC increased fatigue at 3 months (mean ratio 1.13; CI 1.02-1.26), but not at 6 or 12 months. Compared to control, adolescents participating in FACE-TC agreed that \"I feel prepared for the future\" (76% vs 94%) and \"I feel we are now on the same page\" (76% vs 94%) at 3 months, but not at 12 months.CONCLUSIONSThere were no significant differences in quality of life between groups until 1 year, except for fatigue. FACE-TC had late effects, increasing adolescents' anxiety, depressive symptoms, and pain interference. Reassessment at 1 year is clinically important.","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":"7 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CONTEXTExtubation failure (EF) is common in preterm neonates and may be associated with adverse outcomes.OBJECTIVETo systematically review and meta-analyze the existing literature on predictors and outcomes of EF in preterm neonates.DATA SOURCESMEDLINE, Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Embase (OvidSP), CINAHL (EBSCOHost), and Cochrane Library (Wiley) from 1995 onward. The search strategy was developed by a reference librarian.STUDY SELECTIONExperimental or observational studies reporting on predictors and/or outcomes related to EF (defined as reintubation within 7 days) in preterm neonates less than 37 weeks were eligible. Predictors included machine learning (ML) algorithms and lung ultrasound (LUS). Main outcome of interest was association of EF with mortality and/or bronchopulmonary dysplasia (BPD).DATA EXTRACTIONStudies identified by the search strategy were screened based on title and abstract. Data from included studies were extracted independently by 2 authors, along with adjudication of risk of bias. RevMan Web was used to conduct meta-analyses.RESULTSOut of 8336 studies screened, 120 were included. Neonates with lower gestational age at birth, birthweight, postmenstrual age, and weight at extubation were more likely to experience EF. Higher level of pre-extubation respiratory support, indicated by lower pre-extubation pH and higher pre-extubation mean airway pressure, fraction of inspired oxygen, and Pco2 were associated with EF risk. ML models showed variable accuracy and lower external validity. LUS may be a promising predictor, though scoring systems varied. EF was associated with higher odds of mortality and/or BPD (pooled odds ratio [OR], 4.7; 95% CI, 2.84-7.76) as well as the individual components of the composite: mortality (pooled OR, 3.87; 95% CI, 2.35-6.36) and BPD (pooled OR, 3.27; 95% CI, 2.54-4.21).LIMITATIONSAssociations were derived from unadjusted data, precluding a definitive causal relationship between EF and predictors/outcomes.CONCLUSIONSLower gestational and chronological age and higher levels of pre-extubation ventilation support were associated with EF. ML models and LUS scores require further validation in larger studies. EF was associated with mortality and/or BPD.
{"title":"Predictors and Outcomes of Extubation Failure in Preterm Neonates: A Systematic Review.","authors":"Lisiane Hoff Calegari,Medha Goyal,Sourabh Dutta,Amit Mukerji","doi":"10.1542/peds.2024-068677","DOIUrl":"https://doi.org/10.1542/peds.2024-068677","url":null,"abstract":"CONTEXTExtubation failure (EF) is common in preterm neonates and may be associated with adverse outcomes.OBJECTIVETo systematically review and meta-analyze the existing literature on predictors and outcomes of EF in preterm neonates.DATA SOURCESMEDLINE, Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Embase (OvidSP), CINAHL (EBSCOHost), and Cochrane Library (Wiley) from 1995 onward. The search strategy was developed by a reference librarian.STUDY SELECTIONExperimental or observational studies reporting on predictors and/or outcomes related to EF (defined as reintubation within 7 days) in preterm neonates less than 37 weeks were eligible. Predictors included machine learning (ML) algorithms and lung ultrasound (LUS). Main outcome of interest was association of EF with mortality and/or bronchopulmonary dysplasia (BPD).DATA EXTRACTIONStudies identified by the search strategy were screened based on title and abstract. Data from included studies were extracted independently by 2 authors, along with adjudication of risk of bias. RevMan Web was used to conduct meta-analyses.RESULTSOut of 8336 studies screened, 120 were included. Neonates with lower gestational age at birth, birthweight, postmenstrual age, and weight at extubation were more likely to experience EF. Higher level of pre-extubation respiratory support, indicated by lower pre-extubation pH and higher pre-extubation mean airway pressure, fraction of inspired oxygen, and Pco2 were associated with EF risk. ML models showed variable accuracy and lower external validity. LUS may be a promising predictor, though scoring systems varied. EF was associated with higher odds of mortality and/or BPD (pooled odds ratio [OR], 4.7; 95% CI, 2.84-7.76) as well as the individual components of the composite: mortality (pooled OR, 3.87; 95% CI, 2.35-6.36) and BPD (pooled OR, 3.27; 95% CI, 2.54-4.21).LIMITATIONSAssociations were derived from unadjusted data, precluding a definitive causal relationship between EF and predictors/outcomes.CONCLUSIONSLower gestational and chronological age and higher levels of pre-extubation ventilation support were associated with EF. ML models and LUS scores require further validation in larger studies. EF was associated with mortality and/or BPD.","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":"9 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-16DOI: 10.1542/peds.2024-067552
Fabio Antonio Venancio,Maria Eulina Quilião,Sanny Cerqueira de Oliveira Gabeira,Amanda Torrentes de Carvalho,Silvia Helena Dos Santos Leite,Sheila Maria Barbosa de Lima,Nathalia Dos Santos Alves,Luma da Cruz Moura,Waleska Dias Schwarcz,Adriana de Souza Azevedo,Luiz Henrique Ferraz Demarchi,Marina Castilhos Souza Umaki Zardin,Gislene Garcia de Castro Lichs,Deborah Ledesma Taira,Wagner de Souza Fernandes,Natália Oliveira Alves,Aline Etelvina Casaril Arrua,Ana Isabel do Nascimento,Lisany Krug Mareto,Micael Viana de Azevedo,Camila Guadeluppe Maciel,Márcio José de Medeiros,Moreno Magalhães de Souza Rodrigues,Zilton Vasconcelos,Karin Nielsen-Saines,Rivaldo Venâncio da Cunha,Cláudia Du Bocage Santos-Pinto,Everton Falcão de Oliveira
BACKGROUNDZika virus (ZIKV) infection during pregnancy can lead to congenital Zika syndrome (CZS) and may result in neurodevelopmental alterations in exposed children, with and without CZS. This study aimed to evaluate ZIKV infection during pregnancy as a risk factor for early and long-term adverse outcomes.METHODSThis retrospective-prospective, matched cohort study was conducted in Mato Grosso do Sul, Brazil. Mother-infant pairs exposed and unexposed to ZIKV during pregnancy were enrolled in the study from 2018 to 2022. Clinical and epidemiological data from the gestational period and neonatal evaluations were obtained from the Brazilian health surveillance system. Children were assessed for early (congenital anomalies) and long-term adverse outcomes (neurodevelopmental delay). Incidence risk ratio (IRR) and crude odds ratio (OR) were used to assess associations.RESULTSThe risk of adverse outcomes in exposed children was nearly 3-fold higher (IRR, 2.7; 95% CI, 1.4-5.1) compared with the control group. The risk of motor (IRR, 3.4; 95% CI, 1.2-9.6) and cognitive delay (IRR, 4.7; 95% CI, 1.7-13.0) was significantly higher in exposed children. In 44% of pregnancies wherein maternal infection occurred in the first trimester, at least 1 adverse event was identified in the child, with 11.2-fold greater odds of adverse outcomes (OR, 11.2; 95% CI, 3.6-35.0) compared with children of mothers infected in the third trimester.CONCLUSIONSChildren exposed to ZIKV in utero, even without CZS, demonstrate a greater risk for neurodevelopmental delay in early childhood, with the timing of maternal infection being a significant predictive risk factor.
{"title":"Early and Long-Term Adverse Outcomes of In Utero Zika Exposure.","authors":"Fabio Antonio Venancio,Maria Eulina Quilião,Sanny Cerqueira de Oliveira Gabeira,Amanda Torrentes de Carvalho,Silvia Helena Dos Santos Leite,Sheila Maria Barbosa de Lima,Nathalia Dos Santos Alves,Luma da Cruz Moura,Waleska Dias Schwarcz,Adriana de Souza Azevedo,Luiz Henrique Ferraz Demarchi,Marina Castilhos Souza Umaki Zardin,Gislene Garcia de Castro Lichs,Deborah Ledesma Taira,Wagner de Souza Fernandes,Natália Oliveira Alves,Aline Etelvina Casaril Arrua,Ana Isabel do Nascimento,Lisany Krug Mareto,Micael Viana de Azevedo,Camila Guadeluppe Maciel,Márcio José de Medeiros,Moreno Magalhães de Souza Rodrigues,Zilton Vasconcelos,Karin Nielsen-Saines,Rivaldo Venâncio da Cunha,Cláudia Du Bocage Santos-Pinto,Everton Falcão de Oliveira","doi":"10.1542/peds.2024-067552","DOIUrl":"https://doi.org/10.1542/peds.2024-067552","url":null,"abstract":"BACKGROUNDZika virus (ZIKV) infection during pregnancy can lead to congenital Zika syndrome (CZS) and may result in neurodevelopmental alterations in exposed children, with and without CZS. This study aimed to evaluate ZIKV infection during pregnancy as a risk factor for early and long-term adverse outcomes.METHODSThis retrospective-prospective, matched cohort study was conducted in Mato Grosso do Sul, Brazil. Mother-infant pairs exposed and unexposed to ZIKV during pregnancy were enrolled in the study from 2018 to 2022. Clinical and epidemiological data from the gestational period and neonatal evaluations were obtained from the Brazilian health surveillance system. Children were assessed for early (congenital anomalies) and long-term adverse outcomes (neurodevelopmental delay). Incidence risk ratio (IRR) and crude odds ratio (OR) were used to assess associations.RESULTSThe risk of adverse outcomes in exposed children was nearly 3-fold higher (IRR, 2.7; 95% CI, 1.4-5.1) compared with the control group. The risk of motor (IRR, 3.4; 95% CI, 1.2-9.6) and cognitive delay (IRR, 4.7; 95% CI, 1.7-13.0) was significantly higher in exposed children. In 44% of pregnancies wherein maternal infection occurred in the first trimester, at least 1 adverse event was identified in the child, with 11.2-fold greater odds of adverse outcomes (OR, 11.2; 95% CI, 3.6-35.0) compared with children of mothers infected in the third trimester.CONCLUSIONSChildren exposed to ZIKV in utero, even without CZS, demonstrate a greater risk for neurodevelopmental delay in early childhood, with the timing of maternal infection being a significant predictive risk factor.","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":"99 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-15DOI: 10.1542/peds.2024-067035
Katelynn E Boerner,Danya A Fox,Levi Du,Daniel L Metzger,Sheila Marshall,Eva M Moore,Pam Narang,Marie-Noelle Wharton,Tim F Oberlander
BACKGROUNDAlthough sex differences in pain are well documented, little is known regarding the relationship between gender and pain. Gender-diverse youth experience unique pain risk factors, including minority stress exposure, but are underrepresented in research.OBJECTIVEElicit experiences of gender-diverse youth who live with chronic pain.METHODSSemistructured interviews were conducted with youth virtually using Zoom. Youth were recruited from a Canadian tertiary care pediatric hospital, community-based clinics, and the general population. Interviews were recorded, transcribed, and analyzed with a patient partner using reflexive thematic analysis, integrating relevant existing theoretical and empirical models for understanding gender and pain, identity development, minority stress, and intersectionality.RESULTSThe final sample included 19 youth who represented a variety of gender identities and pain conditions and reported accessing a range of types and levels of care. Three themes were identified through qualitative analysis: (1) the fight to legitimize both their pain and gender, (2) the tension between affirming gender and managing pain and the role of gender euphoria as a buffer against pain, and (3) the role of intersecting (eg, neurodiversity and race) identities in understanding gender-diverse youths' pain experiences.CONCLUSIONSIn a diverse sample of gender-diverse youth who live with chronic pain, experiences of invalidation and difficulty managing pain were experienced in the context of unique stressors and sources of joy in living as a gender-diverse individual. These results point to the need for more intersectional and affirming pain research and integration of findings into clinical practice.
{"title":"Experiences of Gender-Diverse Youth Living With Chronic Pain.","authors":"Katelynn E Boerner,Danya A Fox,Levi Du,Daniel L Metzger,Sheila Marshall,Eva M Moore,Pam Narang,Marie-Noelle Wharton,Tim F Oberlander","doi":"10.1542/peds.2024-067035","DOIUrl":"https://doi.org/10.1542/peds.2024-067035","url":null,"abstract":"BACKGROUNDAlthough sex differences in pain are well documented, little is known regarding the relationship between gender and pain. Gender-diverse youth experience unique pain risk factors, including minority stress exposure, but are underrepresented in research.OBJECTIVEElicit experiences of gender-diverse youth who live with chronic pain.METHODSSemistructured interviews were conducted with youth virtually using Zoom. Youth were recruited from a Canadian tertiary care pediatric hospital, community-based clinics, and the general population. Interviews were recorded, transcribed, and analyzed with a patient partner using reflexive thematic analysis, integrating relevant existing theoretical and empirical models for understanding gender and pain, identity development, minority stress, and intersectionality.RESULTSThe final sample included 19 youth who represented a variety of gender identities and pain conditions and reported accessing a range of types and levels of care. Three themes were identified through qualitative analysis: (1) the fight to legitimize both their pain and gender, (2) the tension between affirming gender and managing pain and the role of gender euphoria as a buffer against pain, and (3) the role of intersecting (eg, neurodiversity and race) identities in understanding gender-diverse youths' pain experiences.CONCLUSIONSIn a diverse sample of gender-diverse youth who live with chronic pain, experiences of invalidation and difficulty managing pain were experienced in the context of unique stressors and sources of joy in living as a gender-diverse individual. These results point to the need for more intersectional and affirming pain research and integration of findings into clinical practice.","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":"30 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We present the case of a child born with hypoplastic left heart syndrome. After developing multiple complications following the first surgical stage (Norwood procedure), her parents decide not to proceed with the second stage (Glenn operation). Cardiac surgeons, pediatric intensivists, a psychologist, and a bioethicist analyze whether further surgical intervention is ethically obligatory. A cardiac surgeon believes that after getting beyond the difficulties of the first stage, the patient seems to be a reasonable candidate for the next procedure. He considers the intervention to be ethically permissible edging on ethically obligatory. The psychologist describes the emotional impact of traumatic experiences like the one experienced by this family. She analyses whether their decision is likely to be aligned with their values and explains the possible mechanisms that justify a decision not to continue with surgery. Physicians, a surgeon, and a bioethicist analyze the parents' perception of excessive suffering based on severe complications that were far worse than expected. They believe that, even if proceding with the Glenn operation is in the child's best interest, state intervention to require the surgery over the parents' objection is not justified.
{"title":"A Controversial Clinical Case of a Child With Hypoplastic Left Heart Syndrome.","authors":"Agustín Silberberg,Thomas Iolster,Christian Pizarro,Adrienne Borschuk,Josefina Castro Méndez,Christian Kreutzer,Armand H Matheny Antommaria","doi":"10.1542/peds.2024-065655","DOIUrl":"https://doi.org/10.1542/peds.2024-065655","url":null,"abstract":"We present the case of a child born with hypoplastic left heart syndrome. After developing multiple complications following the first surgical stage (Norwood procedure), her parents decide not to proceed with the second stage (Glenn operation). Cardiac surgeons, pediatric intensivists, a psychologist, and a bioethicist analyze whether further surgical intervention is ethically obligatory. A cardiac surgeon believes that after getting beyond the difficulties of the first stage, the patient seems to be a reasonable candidate for the next procedure. He considers the intervention to be ethically permissible edging on ethically obligatory. The psychologist describes the emotional impact of traumatic experiences like the one experienced by this family. She analyses whether their decision is likely to be aligned with their values and explains the possible mechanisms that justify a decision not to continue with surgery. Physicians, a surgeon, and a bioethicist analyze the parents' perception of excessive suffering based on severe complications that were far worse than expected. They believe that, even if proceding with the Glenn operation is in the child's best interest, state intervention to require the surgery over the parents' objection is not justified.","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":"30 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Context: Exposure to adverse childhood experiences (ACEs) is associated with adverse impacts on subsequent generations. The extent to which caregiver ACEs are associated with their child's ACE score is unclear.
Objective: To meta-analytically examine the association between caregiver and child ACE score. Potential moderators of this association were explored.
Data sources: Systematic searches were conducted using MEDLINE, Embase, PsycINFO, and CINHAL from 1998, the year the ACEs questionnaire was published, to February 19, 2024.
Study selection: Inclusion criteria were that the ACEs questionnaire was completed for both caregiver and child, an effect size was available, and the study was published in English.
Data extraction: Variables extracted included sample size and magnitude of association between caregiver ACEs and child ACEs, mean caregiver and child age, sex (% female), race and ethnicity, and informant of ACEs.
Results: Seventeen samples (4872 caregiver-child dyads) met inclusion criterion. Results revealed a large pooled-effect size between caregiver and child ACEs (r = 0.33; 95% CI, 0.25-0.41; P < .001), such that higher caregiver ACEs score was associated with higher child ACEs score. This association was stronger among studies with younger caregivers and studies that utilized caregiver-report compared with child self-report of ACEs.
Limitations: Many studies were conducted in North America with female caregiver samples, limiting generalizability beyond these populations.
Conclusions: Caregiver ACEs were strongly associated with child ACEs. Prevention and intervention efforts for caregivers should be trauma informed and focused on bolstering protective factors that may break cycles of intergenerational risk.
{"title":"Caregiver and Child Adverse Childhood Experiences: A Meta-Analysis.","authors":"Jenney Zhu, Audrey-Ann Deneault, Jessica Turgeon, Sheri Madigan","doi":"10.1542/peds.2024-068578","DOIUrl":"https://doi.org/10.1542/peds.2024-068578","url":null,"abstract":"<p><strong>Context: </strong>Exposure to adverse childhood experiences (ACEs) is associated with adverse impacts on subsequent generations. The extent to which caregiver ACEs are associated with their child's ACE score is unclear.</p><p><strong>Objective: </strong>To meta-analytically examine the association between caregiver and child ACE score. Potential moderators of this association were explored.</p><p><strong>Data sources: </strong>Systematic searches were conducted using MEDLINE, Embase, PsycINFO, and CINHAL from 1998, the year the ACEs questionnaire was published, to February 19, 2024.</p><p><strong>Study selection: </strong>Inclusion criteria were that the ACEs questionnaire was completed for both caregiver and child, an effect size was available, and the study was published in English.</p><p><strong>Data extraction: </strong>Variables extracted included sample size and magnitude of association between caregiver ACEs and child ACEs, mean caregiver and child age, sex (% female), race and ethnicity, and informant of ACEs.</p><p><strong>Results: </strong>Seventeen samples (4872 caregiver-child dyads) met inclusion criterion. Results revealed a large pooled-effect size between caregiver and child ACEs (r = 0.33; 95% CI, 0.25-0.41; P < .001), such that higher caregiver ACEs score was associated with higher child ACEs score. This association was stronger among studies with younger caregivers and studies that utilized caregiver-report compared with child self-report of ACEs.</p><p><strong>Limitations: </strong>Many studies were conducted in North America with female caregiver samples, limiting generalizability beyond these populations.</p><p><strong>Conclusions: </strong>Caregiver ACEs were strongly associated with child ACEs. Prevention and intervention efforts for caregivers should be trauma informed and focused on bolstering protective factors that may break cycles of intergenerational risk.</p>","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-14DOI: 10.1542/peds.2024-067966
Carolyn Foster, Elaine Lin, James A Feinstein, Rebecca Seltzer, Robert J Graham, Cara Coleman, Erin Ward, Ryan J Coller, Sarah Sobotka, Jay G Berry
Pediatric home health care represents a vital system of care for children with disability and medical complexity, encompassing services provided by family caregivers and nonfamily home health care providers and the use of durable medical equipment and supplies. Home health care is medically necessary for the physiologic health of children with disability and medical complexity and for their participation and function within home, school, and community settings. While the study of pediatric home health care in the United States has increased in the last decade, its research remains primarily methodologically limited to observational studies. Dedicated funding and research efforts are needed to transform American home health care research to address multifaceted outcomes valued by families and providers as well as payers and government programs. In this paper, we review the recent literature in pediatric home health care and then propose an actional agenda that could address its missing evidence base. We posit that pediatricians should partner with family caregiving experts and patients to advance knowledge about child and family health outcomes, home health care use, new models of care, and optimal approaches to education and training while also considering meaningful approaches to address disparities. The creation of an American pediatric home health care data-sharing consortium, patient registry, and reproducible access and quality measures is also needed. Most importantly, efforts should center on patient- and family-centered health priorities, with the goal of ensuring equitable outcomes for every child and family.
{"title":"Home Health Care Research for Children With Disability and Medical Complexity.","authors":"Carolyn Foster, Elaine Lin, James A Feinstein, Rebecca Seltzer, Robert J Graham, Cara Coleman, Erin Ward, Ryan J Coller, Sarah Sobotka, Jay G Berry","doi":"10.1542/peds.2024-067966","DOIUrl":"https://doi.org/10.1542/peds.2024-067966","url":null,"abstract":"<p><p>Pediatric home health care represents a vital system of care for children with disability and medical complexity, encompassing services provided by family caregivers and nonfamily home health care providers and the use of durable medical equipment and supplies. Home health care is medically necessary for the physiologic health of children with disability and medical complexity and for their participation and function within home, school, and community settings. While the study of pediatric home health care in the United States has increased in the last decade, its research remains primarily methodologically limited to observational studies. Dedicated funding and research efforts are needed to transform American home health care research to address multifaceted outcomes valued by families and providers as well as payers and government programs. In this paper, we review the recent literature in pediatric home health care and then propose an actional agenda that could address its missing evidence base. We posit that pediatricians should partner with family caregiving experts and patients to advance knowledge about child and family health outcomes, home health care use, new models of care, and optimal approaches to education and training while also considering meaningful approaches to address disparities. The creation of an American pediatric home health care data-sharing consortium, patient registry, and reproducible access and quality measures is also needed. Most importantly, efforts should center on patient- and family-centered health priorities, with the goal of ensuring equitable outcomes for every child and family.</p>","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-13DOI: 10.1542/peds.2024-069242
Lori Feldman-Winter, Ann Kellams
{"title":"Opportunities to Address Safe Infant Sleep and Breastfeeding.","authors":"Lori Feldman-Winter, Ann Kellams","doi":"10.1542/peds.2024-069242","DOIUrl":"https://doi.org/10.1542/peds.2024-069242","url":null,"abstract":"","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-13DOI: 10.1542/peds.2024-067659
Caryn M Decker, Elizabeth Dunlevey, Lien Nguyen, Kathy Jo Stence, Erin McCarty, Tamala Gondwe Jean-Charles, Tara Trego, Zhen-Qiang Ma
Objectives: To assess whether exposure to an infant safe sleep initiative was associated with maternal report of infant safe sleep practice at home and to identify other predictive factors.
Methods: After linking Pennsylvania data on infant safe sleep initiative implementation at 27 hospitals to birth certificate and Pregnancy Risk Assessment Monitoring System (PRAMS) data from 2017 to 2021, we generated descriptive statistics to compare infant safe sleep practice and other characteristics between respondents exposed to the initiative and all other PRAMS respondents with a hospital birth. Using multivariable logistic regression, we modeled the association between exposure to the initiative and maternal self-report of placing their infant to sleep on their back, on a separate surface, without soft objects, or room sharing without bed sharing.
Results: PRAMS respondents who gave birth in a hospital that had implemented the infant safe sleep initiative were more likely to report placing their infant on their back to sleep, on a separate sleep surface, or without soft objects compared with those who were not exposed to the initiative after adjusting for maternal characteristics and birth parameters. No significant effect was observed on room sharing without bed sharing. When the overall number of reported infant safe sleep practices reported by respondents was considered as an outcome, the association with exposure to the safe sleep initiative persisted.
Conclusion: This study demonstrates the association between exposure to a hospital-based infant safe sleep initiative and subsequent safe sleep practice at home. Additional study on the equity of such initiatives may be warranted.
{"title":"A Hospital-Based Initiative for Infant Safe Sleep Practice.","authors":"Caryn M Decker, Elizabeth Dunlevey, Lien Nguyen, Kathy Jo Stence, Erin McCarty, Tamala Gondwe Jean-Charles, Tara Trego, Zhen-Qiang Ma","doi":"10.1542/peds.2024-067659","DOIUrl":"https://doi.org/10.1542/peds.2024-067659","url":null,"abstract":"<p><strong>Objectives: </strong>To assess whether exposure to an infant safe sleep initiative was associated with maternal report of infant safe sleep practice at home and to identify other predictive factors.</p><p><strong>Methods: </strong>After linking Pennsylvania data on infant safe sleep initiative implementation at 27 hospitals to birth certificate and Pregnancy Risk Assessment Monitoring System (PRAMS) data from 2017 to 2021, we generated descriptive statistics to compare infant safe sleep practice and other characteristics between respondents exposed to the initiative and all other PRAMS respondents with a hospital birth. Using multivariable logistic regression, we modeled the association between exposure to the initiative and maternal self-report of placing their infant to sleep on their back, on a separate surface, without soft objects, or room sharing without bed sharing.</p><p><strong>Results: </strong>PRAMS respondents who gave birth in a hospital that had implemented the infant safe sleep initiative were more likely to report placing their infant on their back to sleep, on a separate sleep surface, or without soft objects compared with those who were not exposed to the initiative after adjusting for maternal characteristics and birth parameters. No significant effect was observed on room sharing without bed sharing. When the overall number of reported infant safe sleep practices reported by respondents was considered as an outcome, the association with exposure to the safe sleep initiative persisted.</p><p><strong>Conclusion: </strong>This study demonstrates the association between exposure to a hospital-based infant safe sleep initiative and subsequent safe sleep practice at home. Additional study on the equity of such initiatives may be warranted.</p>","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}