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Resource Utilization and Cost in Management of Febrile Infants After the 2021 Clinical Guideline. 2021年临床指南实施后发热婴儿管理的资源利用与成本
IF 8 2区 医学 Q1 PEDIATRICS Pub Date : 2025-01-17 DOI: 10.1542/peds.2024-068028
Elena Dingle,Jonathan H Pelletier,Michael L Forbes,Prabi Rajbhandari
OBJECTIVEThe 2021 American Academy of Pediatrics clinical practice guideline (CPG) for well-appearing febrile infants aims to promote evidence-based care, reduce practice variability, enhance care quality, and optimize cost. We aimed to examine the trends in resource utilization and cost associated with the evaluation and management of febrile infants aged 8 to 60 days before and after the CPG's publication.METHODSWe performed a retrospective cross-sectional study using the Pediatric Health Information Systems Database, covering the periods of August 2019 to July 2021 (pre-CPG) and August 2021 to July 2023 (post-CPG). We analyzed the use of antibiotics, acyclovir, laboratory studies, lumbar punctures (LPs), and hospitalizations before and after the CPG publication.RESULTSWe identified 33 736 encounters (12 220 pre-CPG and 21 516 post-CPG). After the CPG, there was a decrease in hospitalization (42.6% vs 34.7%, -7.9% [-9.0% to -6.8%]), antibiotic and acyclovir administration (41.9% vs 33.1%, -8.8% [-9.9% to -7.7%]; 9.7% vs 7.3%, -2.4% [-3.1% to -1.8%]), and LP (31.7% vs 21.8%, -9.9% [-10.9% to -8.9%]). Conversely, the use of C-reactive protein (23.7% vs 32.3%, 8.6% [7.6% to 9.5%]) and procalcitonin (40.1% vs 64.5%, 24.4% [23.3% to 25.5%]) increased. Cost remained unchanged. Age-stratified analysis revealed a significant reduction in hospitalization, antibiotic use, and LP in infants aged older than 22 days, whereas infants younger than 28 days experienced a slight increase in delayed diagnosis of bacteremia and sepsis after the CPG.CONCLUSIONSAfter the CPG, hospitalization, antimicrobial use, and LPs decreased in infants aged older than 22 days, indicating that the CPG may be effective in reducing resource utilization. There was a slight increase in delayed diagnosis of bacteremia and sepsis in infants younger than 28 days.
目的2021 年美国儿科学会针对表现良好的发热婴儿的临床实践指南(CPG)旨在促进循证护理、减少实践变异、提高护理质量并优化成本。我们旨在研究 CPG 发布前后,与 8 到 60 天发热婴儿评估和管理相关的资源利用和成本趋势。方法 我们利用儿科健康信息系统数据库进行了一项回顾性横断面研究,研究时间跨度为 2019 年 8 月到 2021 年 7 月(CPG 发布前)和 2021 年 8 月到 2023 年 7 月(CPG 发布后)。我们分析了 CPG 发布前后抗生素、阿昔洛韦、实验室检查、腰椎穿刺 (LP) 和住院的使用情况。CPG 发布后,住院率(42.6% vs 34.7%,-7.9% [-9.0% to -6.8%])、抗生素和阿昔洛韦用药率(41.9% vs 33.1%,-8.8% [-9.9% to -7.7%];9.7% vs 7.3%,-2.4% [-3.1% to -1.8%] )和 LP(31.7% vs 21.8%,-9.9% [-10.9% to -8.9%])均有所下降。相反,C 反应蛋白(23.7% 对 32.3%,8.6% [7.6% 至 9.5%])和降钙素原(40.1% 对 64.5%,24.4% [23.3% 至 25.5%])的使用率则有所上升。费用保持不变。年龄分层分析表明,采用 CPG 后,22 天以上婴儿的住院率、抗生素使用率和 LP 显著下降,而 28 天以下婴儿的菌血症和败血症延迟诊断率略有上升。28 天以下婴儿的菌血症和败血症延迟诊断率略有上升。
{"title":"Resource Utilization and Cost in Management of Febrile Infants After the 2021 Clinical Guideline.","authors":"Elena Dingle,Jonathan H Pelletier,Michael L Forbes,Prabi Rajbhandari","doi":"10.1542/peds.2024-068028","DOIUrl":"https://doi.org/10.1542/peds.2024-068028","url":null,"abstract":"OBJECTIVEThe 2021 American Academy of Pediatrics clinical practice guideline (CPG) for well-appearing febrile infants aims to promote evidence-based care, reduce practice variability, enhance care quality, and optimize cost. We aimed to examine the trends in resource utilization and cost associated with the evaluation and management of febrile infants aged 8 to 60 days before and after the CPG's publication.METHODSWe performed a retrospective cross-sectional study using the Pediatric Health Information Systems Database, covering the periods of August 2019 to July 2021 (pre-CPG) and August 2021 to July 2023 (post-CPG). We analyzed the use of antibiotics, acyclovir, laboratory studies, lumbar punctures (LPs), and hospitalizations before and after the CPG publication.RESULTSWe identified 33 736 encounters (12 220 pre-CPG and 21 516 post-CPG). After the CPG, there was a decrease in hospitalization (42.6% vs 34.7%, -7.9% [-9.0% to -6.8%]), antibiotic and acyclovir administration (41.9% vs 33.1%, -8.8% [-9.9% to -7.7%]; 9.7% vs 7.3%, -2.4% [-3.1% to -1.8%]), and LP (31.7% vs 21.8%, -9.9% [-10.9% to -8.9%]). Conversely, the use of C-reactive protein (23.7% vs 32.3%, 8.6% [7.6% to 9.5%]) and procalcitonin (40.1% vs 64.5%, 24.4% [23.3% to 25.5%]) increased. Cost remained unchanged. Age-stratified analysis revealed a significant reduction in hospitalization, antibiotic use, and LP in infants aged older than 22 days, whereas infants younger than 28 days experienced a slight increase in delayed diagnosis of bacteremia and sepsis after the CPG.CONCLUSIONSAfter the CPG, hospitalization, antimicrobial use, and LPs decreased in infants aged older than 22 days, indicating that the CPG may be effective in reducing resource utilization. There was a slight increase in delayed diagnosis of bacteremia and sepsis in infants younger than 28 days.","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":"55 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric Advance Care Planning and Adolescent Preparedness and Quality of Life: An RCT. 儿科预先护理计划与青少年的准备程度和生活质量:一项 RCT。
IF 8 2区 医学 Q1 PEDIATRICS Pub Date : 2025-01-17 DOI: 10.1542/peds.2024-068699
Sarah Friebert,Eduardo A Trujillo Rivera,Justin N Baker,Jessica D Thompkins,Daniel Grossoehme,Jennifer Needle,Maureen E Lyon
BACKGROUND AND OBJECTIVETo evaluate the efficacy of Family-Centered Advance Care Planning for Teens With Cancer (FACE-TC) on adolescents' quality of life.METHODSA clinical trial randomized adolescent-family dyads at a 2:1 ratio to either FACE-TC or control. FACE-TC dyads received 3 weekly 60-minute sessions: Lyon Pediatric Advance Care Planning Survey; Next Steps: Respecting Choices; and Five Wishes. Generalized mixed-effect models evaluated efficacy at 3, 6, and 12 months after intervention measured by FACIT-SP-Ex-V4 (meaning/peace, faith) and PROMIS pediatric (anxiety; depressive symptoms; pain interference, fatigue). Fisher exact tests assessed decisional support and preparedness.RESULTSAdolescents (n = 126) were mean age 17 years, 57% female, and 79% white. No significant differences were found between groups for faith or meaning/peace. At 12 months after intervention compared to control, FACE-TC increased anxiety (mean ratio 1.14; CI 1.04-1.25), depressive symptoms (mean ratio 1.12; CI 1.02-1.22), and pain interference (mean ratio 1.10; CI 1.00-1.20), but not at 3 or 6 months. FACE-TC increased fatigue at 3 months (mean ratio 1.13; CI 1.02-1.26), but not at 6 or 12 months. Compared to control, adolescents participating in FACE-TC agreed that "I feel prepared for the future" (76% vs 94%) and "I feel we are now on the same page" (76% vs 94%) at 3 months, but not at 12 months.CONCLUSIONSThere were no significant differences in quality of life between groups until 1 year, except for fatigue. FACE-TC had late effects, increasing adolescents' anxiety, depressive symptoms, and pain interference. Reassessment at 1 year is clinically important.
背景和目标评估以家庭为中心的青少年癌症患者预先护理计划(FACE-TC)对青少年生活质量的影响。方法临床试验将青少年-家庭组合按 2:1 的比例随机分配到 FACE-TC 或对照组中。FACE-TC 组合每周接受 3 次 60 分钟的治疗:里昂儿科预先护理规划调查;下一步:尊重选择 "和 "五个愿望"。广义混合效应模型通过 FACIT-SP-Ex-V4(意义/平和、信仰)和 PROMIS 儿科(焦虑、抑郁症状、疼痛干扰、疲劳)评估了干预后 3、6 和 12 个月的疗效。结果青少年(126 人)平均年龄为 17 岁,57% 为女性,79% 为白人。各组之间在信仰或意义/和平方面没有发现明显差异。与对照组相比,在干预后 12 个月,FACE-TC 增加了焦虑(平均比率为 1.14;CI 为 1.04-1.25)、抑郁症状(平均比率为 1.12;CI 为 1.02-1.22)和疼痛干扰(平均比率为 1.10;CI 为 1.00-1.20),但在 3 个月或 6 个月时没有增加。FACE-TC 在 3 个月时增加了疲劳感(平均比率为 1.13;CI 为 1.02-1.26),但在 6 个月或 12 个月时没有增加。与对照组相比,参加 FACE-TC 的青少年在 3 个月时同意 "我觉得自己为未来做好了准备"(76% 对 94%),在 12 个月时不同意 "我觉得我们现在在同一起跑线上"(76% 对 94%)。FACE-TC 具有后期效应,会增加青少年的焦虑、抑郁症状和疼痛干扰。一年后的重新评估在临床上非常重要。
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引用次数: 0
Predictors and Outcomes of Extubation Failure in Preterm Neonates: A Systematic Review. 早产儿拔管失败的预测因素和结果:一项系统综述。
IF 8 2区 医学 Q1 PEDIATRICS Pub Date : 2025-01-16 DOI: 10.1542/peds.2024-068677
Lisiane Hoff Calegari,Medha Goyal,Sourabh Dutta,Amit Mukerji
CONTEXTExtubation failure (EF) is common in preterm neonates and may be associated with adverse outcomes.OBJECTIVETo systematically review and meta-analyze the existing literature on predictors and outcomes of EF in preterm neonates.DATA SOURCESMEDLINE, Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Embase (OvidSP), CINAHL (EBSCOHost), and Cochrane Library (Wiley) from 1995 onward. The search strategy was developed by a reference librarian.STUDY SELECTIONExperimental or observational studies reporting on predictors and/or outcomes related to EF (defined as reintubation within 7 days) in preterm neonates less than 37 weeks were eligible. Predictors included machine learning (ML) algorithms and lung ultrasound (LUS). Main outcome of interest was association of EF with mortality and/or bronchopulmonary dysplasia (BPD).DATA EXTRACTIONStudies identified by the search strategy were screened based on title and abstract. Data from included studies were extracted independently by 2 authors, along with adjudication of risk of bias. RevMan Web was used to conduct meta-analyses.RESULTSOut of 8336 studies screened, 120 were included. Neonates with lower gestational age at birth, birthweight, postmenstrual age, and weight at extubation were more likely to experience EF. Higher level of pre-extubation respiratory support, indicated by lower pre-extubation pH and higher pre-extubation mean airway pressure, fraction of inspired oxygen, and Pco2 were associated with EF risk. ML models showed variable accuracy and lower external validity. LUS may be a promising predictor, though scoring systems varied. EF was associated with higher odds of mortality and/or BPD (pooled odds ratio [OR], 4.7; 95% CI, 2.84-7.76) as well as the individual components of the composite: mortality (pooled OR, 3.87; 95% CI, 2.35-6.36) and BPD (pooled OR, 3.27; 95% CI, 2.54-4.21).LIMITATIONSAssociations were derived from unadjusted data, precluding a definitive causal relationship between EF and predictors/outcomes.CONCLUSIONSLower gestational and chronological age and higher levels of pre-extubation ventilation support were associated with EF. ML models and LUS scores require further validation in larger studies. EF was associated with mortality and/or BPD.
背景:插管失败(EF)在早产儿中很常见,并可能与不良后果相关。目的系统回顾和荟萃分析早产儿EF的预测因素和预后。数据来源medline, Epub Ahead of Print, In-Process & Other Non-Indexed citation, Embase (OvidSP), CINAHL (EBSCOHost), Cochrane Library (Wiley)自1995年起。这个搜索策略是由一位参考图书管理员制定的。研究选择:报告少于37周的早产儿EF(定义为7天内再插管)相关预测因素和/或结果的实验或观察性研究符合条件。预测指标包括机器学习(ML)算法和肺超声(LUS)。主要结局是EF与死亡率和/或支气管肺发育不良(BPD)的关系。数据提取通过检索策略识别的研究根据标题和摘要进行筛选。纳入研究的数据由两位作者独立提取,并对偏倚风险进行了判定。采用RevMan Web进行meta分析。结果在筛选的8336项研究中,纳入120项。出生时胎龄、出生体重、经后年龄和拔管时体重较低的新生儿更容易发生EF。较高水平的拔管前呼吸支持,即较低的拔管前pH值和较高的拔管前平均气道压力、吸入氧气分数和二氧化碳分压与EF风险相关。ML模型的准确性不稳定,外部效度较低。LUS可能是一个很有希望的预测指标,尽管评分系统各不相同。EF与较高的死亡率和/或BPD相关(合并优势比[or], 4.7;95% CI, 2.84-7.76)以及组合的单个组成部分:死亡率(合并OR, 3.87;95% CI, 2.35-6.36)和BPD(合并OR, 3.27;95% ci, 2.54-4.21)。局限性:关联来源于未经调整的数据,排除了EF和预测因子/结果之间明确的因果关系。结论较低的胎龄和实足年龄以及较高的拔管前通气支持水平与EF相关。ML模型和LUS评分需要在更大规模的研究中进一步验证。EF与死亡率和/或BPD相关。
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引用次数: 0
Early and Long-Term Adverse Outcomes of In Utero Zika Exposure. 子宫内寨卡病毒暴露的早期和长期不良后果。
IF 8 2区 医学 Q1 PEDIATRICS Pub Date : 2025-01-16 DOI: 10.1542/peds.2024-067552
Fabio Antonio Venancio,Maria Eulina Quilião,Sanny Cerqueira de Oliveira Gabeira,Amanda Torrentes de Carvalho,Silvia Helena Dos Santos Leite,Sheila Maria Barbosa de Lima,Nathalia Dos Santos Alves,Luma da Cruz Moura,Waleska Dias Schwarcz,Adriana de Souza Azevedo,Luiz Henrique Ferraz Demarchi,Marina Castilhos Souza Umaki Zardin,Gislene Garcia de Castro Lichs,Deborah Ledesma Taira,Wagner de Souza Fernandes,Natália Oliveira Alves,Aline Etelvina Casaril Arrua,Ana Isabel do Nascimento,Lisany Krug Mareto,Micael Viana de Azevedo,Camila Guadeluppe Maciel,Márcio José de Medeiros,Moreno Magalhães de Souza Rodrigues,Zilton Vasconcelos,Karin Nielsen-Saines,Rivaldo Venâncio da Cunha,Cláudia Du Bocage Santos-Pinto,Everton Falcão de Oliveira
BACKGROUNDZika virus (ZIKV) infection during pregnancy can lead to congenital Zika syndrome (CZS) and may result in neurodevelopmental alterations in exposed children, with and without CZS. This study aimed to evaluate ZIKV infection during pregnancy as a risk factor for early and long-term adverse outcomes.METHODSThis retrospective-prospective, matched cohort study was conducted in Mato Grosso do Sul, Brazil. Mother-infant pairs exposed and unexposed to ZIKV during pregnancy were enrolled in the study from 2018 to 2022. Clinical and epidemiological data from the gestational period and neonatal evaluations were obtained from the Brazilian health surveillance system. Children were assessed for early (congenital anomalies) and long-term adverse outcomes (neurodevelopmental delay). Incidence risk ratio (IRR) and crude odds ratio (OR) were used to assess associations.RESULTSThe risk of adverse outcomes in exposed children was nearly 3-fold higher (IRR, 2.7; 95% CI, 1.4-5.1) compared with the control group. The risk of motor (IRR, 3.4; 95% CI, 1.2-9.6) and cognitive delay (IRR, 4.7; 95% CI, 1.7-13.0) was significantly higher in exposed children. In 44% of pregnancies wherein maternal infection occurred in the first trimester, at least 1 adverse event was identified in the child, with 11.2-fold greater odds of adverse outcomes (OR, 11.2; 95% CI, 3.6-35.0) compared with children of mothers infected in the third trimester.CONCLUSIONSChildren exposed to ZIKV in utero, even without CZS, demonstrate a greater risk for neurodevelopmental delay in early childhood, with the timing of maternal infection being a significant predictive risk factor.
背景妊娠期感染寨卡病毒(ZIKV)可导致先天性寨卡综合征(CZS),并可能导致受感染儿童的神经发育改变,无论是否患有寨卡综合征。本研究旨在评估妊娠期 ZIKV 感染作为早期和长期不良后果风险因素的影响。从 2018 年到 2022 年,在孕期暴露于和未暴露于 ZIKV 的母婴配对被纳入研究。妊娠期的临床和流行病学数据以及新生儿评估数据均来自巴西卫生监督系统。对儿童的早期(先天性畸形)和长期不良后果(神经发育迟缓)进行了评估。结果与对照组相比,暴露儿童出现不良后果的风险高出近 3 倍(IRR,2.7;95% CI,1.4-5.1)。暴露组儿童的运动风险(IRR,3.4;95% CI,1.2-9.6)和认知延迟风险(IRR,4.7;95% CI,1.7-13.0)显著高于对照组。44%的孕妇在妊娠头三个月感染了ZIKV,其子女至少发生了1例不良事件,与母亲在妊娠第三个月感染的子女相比,发生不良后果的几率高出11.2倍(OR,11.2;95% CI,3.6-35.0)。
{"title":"Early and Long-Term Adverse Outcomes of In Utero Zika Exposure.","authors":"Fabio Antonio Venancio,Maria Eulina Quilião,Sanny Cerqueira de Oliveira Gabeira,Amanda Torrentes de Carvalho,Silvia Helena Dos Santos Leite,Sheila Maria Barbosa de Lima,Nathalia Dos Santos Alves,Luma da Cruz Moura,Waleska Dias Schwarcz,Adriana de Souza Azevedo,Luiz Henrique Ferraz Demarchi,Marina Castilhos Souza Umaki Zardin,Gislene Garcia de Castro Lichs,Deborah Ledesma Taira,Wagner de Souza Fernandes,Natália Oliveira Alves,Aline Etelvina Casaril Arrua,Ana Isabel do Nascimento,Lisany Krug Mareto,Micael Viana de Azevedo,Camila Guadeluppe Maciel,Márcio José de Medeiros,Moreno Magalhães de Souza Rodrigues,Zilton Vasconcelos,Karin Nielsen-Saines,Rivaldo Venâncio da Cunha,Cláudia Du Bocage Santos-Pinto,Everton Falcão de Oliveira","doi":"10.1542/peds.2024-067552","DOIUrl":"https://doi.org/10.1542/peds.2024-067552","url":null,"abstract":"BACKGROUNDZika virus (ZIKV) infection during pregnancy can lead to congenital Zika syndrome (CZS) and may result in neurodevelopmental alterations in exposed children, with and without CZS. This study aimed to evaluate ZIKV infection during pregnancy as a risk factor for early and long-term adverse outcomes.METHODSThis retrospective-prospective, matched cohort study was conducted in Mato Grosso do Sul, Brazil. Mother-infant pairs exposed and unexposed to ZIKV during pregnancy were enrolled in the study from 2018 to 2022. Clinical and epidemiological data from the gestational period and neonatal evaluations were obtained from the Brazilian health surveillance system. Children were assessed for early (congenital anomalies) and long-term adverse outcomes (neurodevelopmental delay). Incidence risk ratio (IRR) and crude odds ratio (OR) were used to assess associations.RESULTSThe risk of adverse outcomes in exposed children was nearly 3-fold higher (IRR, 2.7; 95% CI, 1.4-5.1) compared with the control group. The risk of motor (IRR, 3.4; 95% CI, 1.2-9.6) and cognitive delay (IRR, 4.7; 95% CI, 1.7-13.0) was significantly higher in exposed children. In 44% of pregnancies wherein maternal infection occurred in the first trimester, at least 1 adverse event was identified in the child, with 11.2-fold greater odds of adverse outcomes (OR, 11.2; 95% CI, 3.6-35.0) compared with children of mothers infected in the third trimester.CONCLUSIONSChildren exposed to ZIKV in utero, even without CZS, demonstrate a greater risk for neurodevelopmental delay in early childhood, with the timing of maternal infection being a significant predictive risk factor.","PeriodicalId":20028,"journal":{"name":"Pediatrics","volume":"99 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experiences of Gender-Diverse Youth Living With Chronic Pain. 患有慢性疼痛的不同性别青年的经历。
IF 8 2区 医学 Q1 PEDIATRICS Pub Date : 2025-01-15 DOI: 10.1542/peds.2024-067035
Katelynn E Boerner,Danya A Fox,Levi Du,Daniel L Metzger,Sheila Marshall,Eva M Moore,Pam Narang,Marie-Noelle Wharton,Tim F Oberlander
BACKGROUNDAlthough sex differences in pain are well documented, little is known regarding the relationship between gender and pain. Gender-diverse youth experience unique pain risk factors, including minority stress exposure, but are underrepresented in research.OBJECTIVEElicit experiences of gender-diverse youth who live with chronic pain.METHODSSemistructured interviews were conducted with youth virtually using Zoom. Youth were recruited from a Canadian tertiary care pediatric hospital, community-based clinics, and the general population. Interviews were recorded, transcribed, and analyzed with a patient partner using reflexive thematic analysis, integrating relevant existing theoretical and empirical models for understanding gender and pain, identity development, minority stress, and intersectionality.RESULTSThe final sample included 19 youth who represented a variety of gender identities and pain conditions and reported accessing a range of types and levels of care. Three themes were identified through qualitative analysis: (1) the fight to legitimize both their pain and gender, (2) the tension between affirming gender and managing pain and the role of gender euphoria as a buffer against pain, and (3) the role of intersecting (eg, neurodiversity and race) identities in understanding gender-diverse youths' pain experiences.CONCLUSIONSIn a diverse sample of gender-diverse youth who live with chronic pain, experiences of invalidation and difficulty managing pain were experienced in the context of unique stressors and sources of joy in living as a gender-diverse individual. These results point to the need for more intersectional and affirming pain research and integration of findings into clinical practice.
背景:尽管疼痛的性别差异已被充分记录,但性别与疼痛之间的关系尚不清楚。性别多样化的青年经历独特的疼痛风险因素,包括少数民族压力暴露,但在研究中代表性不足。目的引出不同性别的慢性疼痛青年的经历。方法使用Zoom虚拟工具对青少年进行半结构化访谈。从加拿大三级儿科医院、社区诊所和普通人群中招募青少年。访谈记录、转录并与患者合作伙伴使用反身性主题分析进行分析,整合相关的现有理论和经验模型,以理解性别和疼痛、身份发展、少数民族压力和交叉性。结果最后的样本包括19名青年,他们代表了不同的性别认同和疼痛状况,并报告获得了一系列类型和级别的护理。通过定性分析确定了三个主题:(1)使他们的疼痛和性别合法化的斗争;(2)确认性别和管理疼痛之间的紧张关系以及性别欣欣作为疼痛缓冲的作用;(3)交叉(例如,神经多样性和种族)身份在理解性别多样化青年疼痛体验中的作用。结论在一组不同性别的慢性疼痛青年中,作为一个不同性别的个体,他们在不同的压力源和快乐来源的背景下经历了无效感和疼痛管理困难。这些结果表明,需要更多的交叉和肯定的疼痛研究和研究结果整合到临床实践。
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引用次数: 0
A Controversial Clinical Case of a Child With Hypoplastic Left Heart Syndrome. 儿童左心发育不全综合征的争议性临床病例。
IF 8 2区 医学 Q1 PEDIATRICS Pub Date : 2025-01-15 DOI: 10.1542/peds.2024-065655
Agustín Silberberg,Thomas Iolster,Christian Pizarro,Adrienne Borschuk,Josefina Castro Méndez,Christian Kreutzer,Armand H Matheny Antommaria
We present the case of a child born with hypoplastic left heart syndrome. After developing multiple complications following the first surgical stage (Norwood procedure), her parents decide not to proceed with the second stage (Glenn operation). Cardiac surgeons, pediatric intensivists, a psychologist, and a bioethicist analyze whether further surgical intervention is ethically obligatory. A cardiac surgeon believes that after getting beyond the difficulties of the first stage, the patient seems to be a reasonable candidate for the next procedure. He considers the intervention to be ethically permissible edging on ethically obligatory. The psychologist describes the emotional impact of traumatic experiences like the one experienced by this family. She analyses whether their decision is likely to be aligned with their values and explains the possible mechanisms that justify a decision not to continue with surgery. Physicians, a surgeon, and a bioethicist analyze the parents' perception of excessive suffering based on severe complications that were far worse than expected. They believe that, even if proceding with the Glenn operation is in the child's best interest, state intervention to require the surgery over the parents' objection is not justified.
我们提出的情况下,一个孩子出生与发育不良的左心综合征。在第一阶段手术(诺伍德手术)后出现了多种并发症,她的父母决定不进行第二阶段手术(格伦手术)。心脏外科医生、儿科重症医师、一位心理学家和一位生物伦理学家分析进一步的手术干预是否在伦理上是必须的。一位心脏外科医生认为,在克服了第一阶段的困难之后,病人似乎是下一阶段手术的合理候选者。他认为这种干预在道德上是允许的,在道德上是必须的。心理学家描述了像这个家庭所经历的创伤经历对情感的影响。她分析了他们的决定是否可能与他们的价值观一致,并解释了决定不继续手术的可能机制。内科医生、一名外科医生和一名生物伦理学家分析了父母对严重并发症的过度痛苦的看法,这些并发症远比预期的严重得多。他们认为,即使格伦的手术符合孩子的最大利益,政府不顾孩子父母的反对强行进行手术也是不合理的。
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引用次数: 0
Caregiver and Child Adverse Childhood Experiences: A Meta-Analysis. 照顾者与儿童不良童年经历:荟萃分析。
IF 6.2 2区 医学 Q1 PEDIATRICS Pub Date : 2025-01-14 DOI: 10.1542/peds.2024-068578
Jenney Zhu, Audrey-Ann Deneault, Jessica Turgeon, Sheri Madigan

Context: Exposure to adverse childhood experiences (ACEs) is associated with adverse impacts on subsequent generations. The extent to which caregiver ACEs are associated with their child's ACE score is unclear.

Objective: To meta-analytically examine the association between caregiver and child ACE score. Potential moderators of this association were explored.

Data sources: Systematic searches were conducted using MEDLINE, Embase, PsycINFO, and CINHAL from 1998, the year the ACEs questionnaire was published, to February 19, 2024.

Study selection: Inclusion criteria were that the ACEs questionnaire was completed for both caregiver and child, an effect size was available, and the study was published in English.

Data extraction: Variables extracted included sample size and magnitude of association between caregiver ACEs and child ACEs, mean caregiver and child age, sex (% female), race and ethnicity, and informant of ACEs.

Results: Seventeen samples (4872 caregiver-child dyads) met inclusion criterion. Results revealed a large pooled-effect size between caregiver and child ACEs (r = 0.33; 95% CI, 0.25-0.41; P < .001), such that higher caregiver ACEs score was associated with higher child ACEs score. This association was stronger among studies with younger caregivers and studies that utilized caregiver-report compared with child self-report of ACEs.

Limitations: Many studies were conducted in North America with female caregiver samples, limiting generalizability beyond these populations.

Conclusions: Caregiver ACEs were strongly associated with child ACEs. Prevention and intervention efforts for caregivers should be trauma informed and focused on bolstering protective factors that may break cycles of intergenerational risk.

背景:童年不良经历(ace)的暴露与对后代的不良影响有关。照料者的ACE分数与孩子的ACE分数之间的关联程度尚不清楚。目的:对照顾者与儿童ACE评分的关系进行meta分析。对这种关联的潜在调节因素进行了探讨。数据来源:使用MEDLINE、Embase、PsycINFO和CINHAL进行系统检索,检索时间为1998年ace问卷发布之年至2024年2月19日。研究选择:纳入标准为:照顾者和儿童均完成了ace问卷,有效应量,研究以英文发表。数据提取:提取的变量包括样本量和照顾者ace与儿童ace之间的关联程度、照顾者和儿童的平均年龄、性别(女性占比)、种族和民族以及ace的知情者。结果:17份样本(4872对)符合纳入标准。结果显示,照顾者和儿童ace之间存在较大的合并效应(r = 0.33;95% ci, 0.25-0.41;P局限性:许多研究是在北美以女性护理人员为样本进行的,限制了这些人群之外的推广。结论:照顾者ace与儿童ace密切相关。护理人员的预防和干预工作应了解创伤,并侧重于加强可能打破代际风险循环的保护因素。
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引用次数: 0
Home Health Care Research for Children With Disability and Medical Complexity. 针对残疾儿童和医疗复杂性儿童的家庭医疗保健研究。
IF 6.2 2区 医学 Q1 PEDIATRICS Pub Date : 2025-01-14 DOI: 10.1542/peds.2024-067966
Carolyn Foster, Elaine Lin, James A Feinstein, Rebecca Seltzer, Robert J Graham, Cara Coleman, Erin Ward, Ryan J Coller, Sarah Sobotka, Jay G Berry

Pediatric home health care represents a vital system of care for children with disability and medical complexity, encompassing services provided by family caregivers and nonfamily home health care providers and the use of durable medical equipment and supplies. Home health care is medically necessary for the physiologic health of children with disability and medical complexity and for their participation and function within home, school, and community settings. While the study of pediatric home health care in the United States has increased in the last decade, its research remains primarily methodologically limited to observational studies. Dedicated funding and research efforts are needed to transform American home health care research to address multifaceted outcomes valued by families and providers as well as payers and government programs. In this paper, we review the recent literature in pediatric home health care and then propose an actional agenda that could address its missing evidence base. We posit that pediatricians should partner with family caregiving experts and patients to advance knowledge about child and family health outcomes, home health care use, new models of care, and optimal approaches to education and training while also considering meaningful approaches to address disparities. The creation of an American pediatric home health care data-sharing consortium, patient registry, and reproducible access and quality measures is also needed. Most importantly, efforts should center on patient- and family-centered health priorities, with the goal of ensuring equitable outcomes for every child and family.

儿科家庭保健是残疾儿童和医疗复杂儿童的重要保健系统,包括由家庭照顾者和非家庭家庭保健提供者提供的服务,以及使用耐用的医疗设备和用品。家庭保健在医学上对于残疾儿童的生理健康和医疗复杂性以及他们在家庭、学校和社区环境中的参与和功能是必要的。虽然在过去十年中,美国对儿科家庭保健的研究有所增加,但其研究在方法学上仍主要局限于观察性研究。需要专门的资金和研究工作来改变美国家庭医疗保健研究,以解决家庭和提供者以及付款人和政府项目所重视的多方面结果。在本文中,我们回顾了儿科家庭保健的最新文献,然后提出了一个行动议程,可以解决其缺失的证据基础。我们认为,儿科医生应该与家庭护理专家和患者合作,提高对儿童和家庭健康结果、家庭保健使用、新的护理模式和最佳教育和培训方法的认识,同时也考虑有意义的方法来解决差距。还需要建立一个美国儿科家庭卫生保健数据共享联盟、患者登记、可重复访问和质量测量。最重要的是,努力应以病人和家庭为中心的卫生优先事项为中心,目标是确保每个儿童和家庭获得公平的结果。
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引用次数: 0
Opportunities to Address Safe Infant Sleep and Breastfeeding. 解决婴儿安全睡眠和母乳喂养问题的机会。
IF 6.2 2区 医学 Q1 PEDIATRICS Pub Date : 2025-01-13 DOI: 10.1542/peds.2024-069242
Lori Feldman-Winter, Ann Kellams
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引用次数: 0
A Hospital-Based Initiative for Infant Safe Sleep Practice. 以医院为基础的婴儿安全睡眠实践倡议。
IF 6.2 2区 医学 Q1 PEDIATRICS Pub Date : 2025-01-13 DOI: 10.1542/peds.2024-067659
Caryn M Decker, Elizabeth Dunlevey, Lien Nguyen, Kathy Jo Stence, Erin McCarty, Tamala Gondwe Jean-Charles, Tara Trego, Zhen-Qiang Ma

Objectives: To assess whether exposure to an infant safe sleep initiative was associated with maternal report of infant safe sleep practice at home and to identify other predictive factors.

Methods: After linking Pennsylvania data on infant safe sleep initiative implementation at 27 hospitals to birth certificate and Pregnancy Risk Assessment Monitoring System (PRAMS) data from 2017 to 2021, we generated descriptive statistics to compare infant safe sleep practice and other characteristics between respondents exposed to the initiative and all other PRAMS respondents with a hospital birth. Using multivariable logistic regression, we modeled the association between exposure to the initiative and maternal self-report of placing their infant to sleep on their back, on a separate surface, without soft objects, or room sharing without bed sharing.

Results: PRAMS respondents who gave birth in a hospital that had implemented the infant safe sleep initiative were more likely to report placing their infant on their back to sleep, on a separate sleep surface, or without soft objects compared with those who were not exposed to the initiative after adjusting for maternal characteristics and birth parameters. No significant effect was observed on room sharing without bed sharing. When the overall number of reported infant safe sleep practices reported by respondents was considered as an outcome, the association with exposure to the safe sleep initiative persisted.

Conclusion: This study demonstrates the association between exposure to a hospital-based infant safe sleep initiative and subsequent safe sleep practice at home. Additional study on the equity of such initiatives may be warranted.

目的:评估是否暴露于婴儿安全睡眠倡议与母亲报告的婴儿在家安全睡眠实践有关,并确定其他预测因素。方法:将宾夕法尼亚州27家医院实施婴儿安全睡眠倡议的数据与2017年至2021年出生证明和妊娠风险评估监测系统(PRAMS)的数据联系起来,生成描述性统计数据,比较参与该倡议的受访者与所有其他医院分娩的PRAMS受访者的婴儿安全睡眠实践和其他特征。使用多变量逻辑回归,我们模拟了暴露于主动性和母亲自我报告之间的关联,这些报告包括让婴儿躺在自己的背上,在单独的表面上,没有柔软的物体,或者在没有床的情况下共用房间。结果:在实施婴儿安全睡眠倡议的医院分娩的PRAMS受访者在调整了母亲特征和分娩参数后,与没有接触该倡议的受访者相比,更有可能报告将婴儿平躺在床上睡觉,在单独的睡眠表面上睡觉,或者没有柔软的物体。在不共用床的情况下,共用房间没有显著的影响。当被调查者报告的婴儿安全睡眠实践的总数被视为一个结果时,与安全睡眠倡议的接触的关联仍然存在。结论:本研究证明了接受医院婴儿安全睡眠倡议与随后在家安全睡眠实践之间的联系。可能有必要进一步研究这些倡议的公平性。
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引用次数: 0
期刊
Pediatrics
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