DFT calculations were carried-out for some of novel designed structures with basicity and superbasicity potentials. In this research, two series of cyclic phosphorus-containing compound were designed inspiring from 1,3,5,7-tetraazaadamantane and 1,4-diazabicyclo[2,2,2]octane. The proton affinity (PA) in the gas phase was calculated for each of the structures 1–14. Most of the designed structures were found to have higher basicity than that of 1,8-bis(dimethylamino) naphthalene (DMAN) as the threshold of superbasicity (3, 4, 7, 10–14). The effect of heteroatom and substituents type in the ring as well as of internal bond angles on the proton affinity were evaluated. It was found that the structure 14 possesses highest PA value of 1198.27 kJ mol−1 in the gas phase. According to the obtained results, the PA values were significantly amplified by substitution with electron releasing groups on the molecular framework. Also, the limitations created by the ring for the electron donation of the substitutents in the neighborhood of the main phosphazene group are discussed.
{"title":"Basicity characterization of novel designed phosphorus containing cyclic structures by a computational approach","authors":"Nastaran Bormanzadeh , Morteza Rouhani , Bahareh Sadeghi","doi":"10.1080/10426507.2024.2424276","DOIUrl":"10.1080/10426507.2024.2424276","url":null,"abstract":"<div><div>DFT calculations were carried-out for some of novel designed structures with basicity and superbasicity potentials. In this research, two series of cyclic phosphorus-containing compound were designed inspiring from 1,3,5,7-tetraazaadamantane and 1,4-diazabicyclo[2,2,2]octane. The proton affinity (PA) in the gas phase was calculated for each of the structures <strong>1–14</strong>. Most of the designed structures were found to have higher basicity than that of 1,8-bis(dimethylamino) naphthalene (DMAN) as the threshold of superbasicity (<strong>3</strong>, <strong>4</strong>, <strong>7</strong>, <strong>10–14</strong>). The effect of heteroatom and substituents type in the ring as well as of internal bond angles on the proton affinity were evaluated. It was found that the structure <strong>14</strong> possesses highest PA value of 1198.27 kJ mol<sup>−1</sup> in the gas phase. According to the obtained results, the PA values were significantly amplified by substitution with electron releasing groups on the molecular framework. Also, the limitations created by the ring for the electron donation of the substitutents in the neighborhood of the main phosphazene group are discussed.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"199 10","pages":"Pages 856-863"},"PeriodicalIF":1.4,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143144528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-03DOI: 10.1080/10426507.2024.2430544
Xiao Zhang , Fangfang Luo , Le Wang , Mengxia Liu , Wenwen Sun , Yuwei Zhang , Yi Qu
Thiophenol and its derivatives pose a significant threat to the environment and biological systems due to their toxic nature. The imperative need for their detection prompted the development of a "turn-on" fluorescent probe, NI-TPA-1, incorporating 1,8-naphthalimide-triphenylamine as the emission groups and 2,4-dinitrobenzene as the reactive site. Upon introducing 4-methoxythiophenol (MTP), the fluorescence intensity of NI-TPA-1 exhibited a remarkable 18-fold increase, achieving detection limits as low as 20 nM in aqueous solutions. The photo-induced electron transfer (PET) response mechanism was elucidated through density functional theory (DFT) calculations, providing valuable insights into the sensing mechanism of the probe. Furthermore, the practical applicability of NI-TPA-1 was demonstrated through its successful detection of thiophenol in real water samples. The versatility of the probe was further showcased in living cells imaging, highlighting its potential for in vivo applications. This research not only presents a robust solution for the sensitive and selective detection of thiophenol but also underscores the broader significance of NI-TPA-1 in environmental and biomedical contexts.
{"title":"A 1,8-naphthalimide-triphenylamine based fluorescent turn-on probe for thiophenol detection in water samples and living cells","authors":"Xiao Zhang , Fangfang Luo , Le Wang , Mengxia Liu , Wenwen Sun , Yuwei Zhang , Yi Qu","doi":"10.1080/10426507.2024.2430544","DOIUrl":"10.1080/10426507.2024.2430544","url":null,"abstract":"<div><div>Thiophenol and its derivatives pose a significant threat to the environment and biological systems due to their toxic nature. The imperative need for their detection prompted the development of a \"turn-on\" fluorescent probe, NI-TPA-1, incorporating 1,8-naphthalimide-triphenylamine as the emission groups and 2,4-dinitrobenzene as the reactive site. Upon introducing 4-methoxythiophenol (MTP), the fluorescence intensity of NI-TPA-1 exhibited a remarkable 18-fold increase, achieving detection limits as low as 20 nM in aqueous solutions. The photo-induced electron transfer (PET) response mechanism was elucidated through density functional theory (DFT) calculations, providing valuable insights into the sensing mechanism of the probe. Furthermore, the practical applicability of NI-TPA-1 was demonstrated through its successful detection of thiophenol in real water samples. The versatility of the probe was further showcased in living cells imaging, highlighting its potential for <em>in vivo</em> applications. This research not only presents a robust solution for the sensitive and selective detection of thiophenol but also underscores the broader significance of NI-TPA-1 in environmental and biomedical contexts.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"199 10","pages":"Pages 898-906"},"PeriodicalIF":1.4,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The incidence of neurodegenerative Alzheimer’s and Parkinson’s diseases is increasing worldwide every day, and treatment options are currently very limited. There is no definitive cure for these diseases, and the drugs available in clinical practice only provide symptomatic relief without halting the progression of neurodegeneration. One commonly employed strategy in the treatment of Alzheimer’s and Parkinson’s diseases is to return neurotransmitter levels by inhibiting enzymes like cholinesterase (ChE) and monoamine oxidase (MAO). In this research, we focused on investigating the therapeutic potential of 2-[2-(substituted benzylidene)hydrazinyl]-4-(substituted phenyl)thiazole derivatives (2a–2h) by incorporating hydrazine, known for its inhibitory effects on monoamine oxidases, into the structure of molecules that inhibit acetylcholinesterase. Thiazole ring was included in these derivatives due to its reported inhibitory activity against both cholinesterases and monoamine oxidase enzymes. When the enzyme inhibition activities were evaluated, it was determined that compounds 2c, 2d, and 2h showed the highest inhibitory activity against AChE, while compounds 2f and 2h expressed the highest activity against MAO-B. It was determined that compound 2h had the highest inhibitory activity on both AChE (0.030 ± 0.001 μM) and MAO-B (0.048 ± 0.002 μM) and compound 2h was the only compound with conspicuous dual inhibitory activity. Furthermore, molecular docking calculations and molecular dynamics simulations were found to agree with experimental results.
{"title":"New 2-hydrazinothiazole derivatives as potential MAO-A, MAO-B, AChE, and BChE inhibitors","authors":"Beyzanur Tutuş , Asaf Evrim Evren , Begüm Nurpelin Sağlik Özkan , Leyla Yurttaş","doi":"10.1080/10426507.2024.2427148","DOIUrl":"10.1080/10426507.2024.2427148","url":null,"abstract":"<div><div>The incidence of neurodegenerative Alzheimer’s and Parkinson’s diseases is increasing worldwide every day, and treatment options are currently very limited. There is no definitive cure for these diseases, and the drugs available in clinical practice only provide symptomatic relief without halting the progression of neurodegeneration. One commonly employed strategy in the treatment of Alzheimer’s and Parkinson’s diseases is to return neurotransmitter levels by inhibiting enzymes like cholinesterase (ChE) and monoamine oxidase (MAO). In this research, we focused on investigating the therapeutic potential of 2-[2-(substituted benzylidene)hydrazinyl]-4-(substituted phenyl)thiazole derivatives (<strong>2a</strong>–<strong>2h</strong>) by incorporating hydrazine, known for its inhibitory effects on monoamine oxidases, into the structure of molecules that inhibit acetylcholinesterase. Thiazole ring was included in these derivatives due to its reported inhibitory activity against both cholinesterases and monoamine oxidase enzymes. When the enzyme inhibition activities were evaluated, it was determined that compounds <strong>2c</strong>, <strong>2d</strong>, and <strong>2h</strong> showed the highest inhibitory activity against AChE, while compounds <strong>2f</strong> and <strong>2h</strong> expressed the highest activity against MAO-B. It was determined that compound <strong>2h</strong> had the highest inhibitory activity on both AChE (0.030 ± 0.001 μM) and MAO-B (0.048 ± 0.002 μM) and compound <strong>2h</strong> was the only compound with conspicuous dual inhibitory activity. Furthermore, molecular docking calculations and molecular dynamics simulations were found to agree with experimental results.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"199 10","pages":"Pages 864-875"},"PeriodicalIF":1.4,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-03DOI: 10.1080/10426507.2024.2433480
Wansong Zhang , Fujun Cao , Ping Yin , Zhenglong Yang , Yanbin Xu , Feng Wang , Ying Wang , Honglan Cai
Two novel highly efficient polymer composite adsorbents based on 3-chloropropyltriethoxysilane-grafted waste para-aramid (PPTA-CP-AT and PPTA-CP-L, PPTA=poly-p-phenylene terephthamide; CP = 3-chloropropyltriethoxysilane; AT=amino trimethylene phosphonic acid; L=L-proline) have been successfully prepared and characterized. The new adsorbents were synthesized by functionalizing 3-chloropropyltriethoxysilane-grafted waste para-aramid with amino trimethylene phosphonic acid and L-proline, respectively. They have been employed to adsorb gold ions from aqueous solution, and the relevant adsorption behaviors have been investigated in detail. The adsorption isotherms of PPTA-CP-AT and PPTA-CP-L were consistent with the Langmuir isotherm model, and the corresponding kinetics could be best described by the pseudo-second-order kinetic model. In particular, the adsorption capacity of PPTA-CP-L was much higher than the values reported in the literature. In addition, the effect of pH on the gold ions adsorption and the thermodynamic parameters of the adsorption procedure were assessed. The research results indicated that PPTA-CP-AT and PPTA-CP-L are two novel adsorbents with high efficiency in wastewater treatment and recovery of precious gold. In particular PPTA-CP-L, which was obtained through facile esterification synthesis at low temperature, showed an excellent adsorption performance and could be used as potentially excellent adsorbent for gold uptake.
{"title":"Exploration of two novel highly efficient polymer composite materials based on 3-chloropropyltriethoxysilane-grafted waste para-aramid functionalized by organo-phosphonic acid/L-proline and their excellent adsorption performance for gold ions","authors":"Wansong Zhang , Fujun Cao , Ping Yin , Zhenglong Yang , Yanbin Xu , Feng Wang , Ying Wang , Honglan Cai","doi":"10.1080/10426507.2024.2433480","DOIUrl":"10.1080/10426507.2024.2433480","url":null,"abstract":"<div><div>Two novel highly efficient polymer composite adsorbents based on 3-chloropropyltriethoxysilane-grafted waste para-aramid (PPTA-CP-AT and PPTA-CP-L, PPTA=poly-<em>p</em>-phenylene terephthamide; CP = 3-chloropropyltriethoxysilane; AT=amino trimethylene phosphonic acid; L=<em>L</em>-proline) have been successfully prepared and characterized. The new adsorbents were synthesized by functionalizing 3-chloropropyltriethoxysilane-grafted waste para-aramid with amino trimethylene phosphonic acid and <em>L</em>-proline, respectively. They have been employed to adsorb gold ions from aqueous solution, and the relevant adsorption behaviors have been investigated in detail. The adsorption isotherms of PPTA-CP-AT and PPTA-CP-L were consistent with the Langmuir isotherm model, and the corresponding kinetics could be best described by the pseudo-second-order kinetic model. In particular, the adsorption capacity of PPTA-CP-L was much higher than the values reported in the literature. In addition, the effect of pH on the gold ions adsorption and the thermodynamic parameters of the adsorption procedure were assessed. The research results indicated that PPTA-CP-AT and PPTA-CP-L are two novel adsorbents with high efficiency in wastewater treatment and recovery of precious gold. In particular PPTA-CP-L, which was obtained through facile esterification synthesis at low temperature, showed an excellent adsorption performance and could be used as potentially excellent adsorbent for gold uptake.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"199 10","pages":"Pages 907-919"},"PeriodicalIF":1.4,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A number of heterocyclic synthons of biologically active compounds were resolved into enantiomers by enzymatic kinetically controlled deracemization in organic media. High enantioselectivities (>98% ee) and good chemical yields were obtained for all substrates using the corresponding lipases. Among the lipases tested, Candida Antarctica B and Burkholderia cepacia were the most efficient enzymes for resoluting these substrates into enantiomers. These compounds were proposed as starting reactants for important bioactive drug preparation that are of interest to many chemists and pharmacologists. 1-Heteroaroethanols are structural fragments of a number of important medical drugs A method was developed that provided high enantiomeric purity of thiochromanols and 4-hydroxythiochromane 1,1-dioxides. The enantiomeric purity of the compounds was determined by derivatization with Mosher acid, as well as NMR in chiral solvating mediums. Absolute configurations were determined using X-ray diffraction analysis and chiral HPLC.
{"title":"Enzymatic resolution of heterocyclic intermediates for biologically active compound preparation","authors":"Anastasy Kolodiazhna , Dmitry Prysiazhnuk , Oleg Kolodiazhnyi","doi":"10.1080/10426507.2024.2367033","DOIUrl":"10.1080/10426507.2024.2367033","url":null,"abstract":"<div><div>A number of heterocyclic synthons of biologically active compounds were resolved into enantiomers by enzymatic kinetically controlled deracemization in organic media. High enantioselectivities (>98% <em>ee</em>) and good chemical yields were obtained for all substrates using the corresponding lipases. Among the lipases tested, <em>Candida Antarctica</em> B and <em>Burkholderia cepacia</em> were the most efficient enzymes for resoluting these substrates into enantiomers. These compounds were proposed as starting reactants for important bioactive drug preparation that are of interest to many chemists and pharmacologists. 1-Heteroaroethanols are structural fragments of a number of important medical drugs A method was developed that provided high enantiomeric purity of thiochromanols and 4-hydroxythiochromane 1,1-dioxides. The enantiomeric purity of the compounds was determined by derivatization with Mosher acid, as well as NMR in chiral solvating mediums. Absolute configurations were determined using X-ray diffraction analysis and chiral HPLC.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"199 10","pages":"Pages 843-855"},"PeriodicalIF":1.4,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142225246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-03DOI: 10.1080/10426507.2024.2430539
Hit Kardani , Hasit Vaghani , Prachi Patel
In recent years, the study of chemical synthesis has seen a transformation, with an emphasis on increasing efficiency and introducing novel approaches. This article ventures into the field of ultrasound-assisted multicomponent reactions (MCRs), presenting them as a unique method for synthesizing chemicals with physiological applications. Ultrasound technology is employed in these reactions to accelerate reaction kinetics, increase overall efficiency, and create novel molecular assembly paths. The study covers a wide range of applications, from drug discovery to material science, and emphasizes the pioneering significance of ultrasound-assisted MCRs in the quest for bioactive compounds. The study highlights the synergistic relationship between ultrasound technology and multicomponent chemistry by reviewing major research and methodology, as well as providing insights into their practical applications and fundamental principles. The review also underlines the significance of lowering solvent consumption and waste creation. As the field of synthesis evolves, this review stimulates additional research into ultrasound-assisted MCRs, resulting in a new era of creativity in the development of therapeutically useful molecules.
{"title":"Green waves in medicinal chemistry: ultrasound driven multicomponent reactions for sustainable synthesis of biologically active molecules","authors":"Hit Kardani , Hasit Vaghani , Prachi Patel","doi":"10.1080/10426507.2024.2430539","DOIUrl":"10.1080/10426507.2024.2430539","url":null,"abstract":"<div><div>In recent years, the study of chemical synthesis has seen a transformation, with an emphasis on increasing efficiency and introducing novel approaches. This article ventures into the field of ultrasound-assisted multicomponent reactions (MCRs), presenting them as a unique method for synthesizing chemicals with physiological applications. Ultrasound technology is employed in these reactions to accelerate reaction kinetics, increase overall efficiency, and create novel molecular assembly paths. The study covers a wide range of applications, from drug discovery to material science, and emphasizes the pioneering significance of ultrasound-assisted MCRs in the quest for bioactive compounds. The study highlights the synergistic relationship between ultrasound technology and multicomponent chemistry by reviewing major research and methodology, as well as providing insights into their practical applications and fundamental principles. The review also underlines the significance of lowering solvent consumption and waste creation. As the field of synthesis evolves, this review stimulates additional research into ultrasound-assisted MCRs, resulting in a new era of creativity in the development of therapeutically useful molecules.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"199 10","pages":"Pages 876-897"},"PeriodicalIF":1.4,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-02DOI: 10.1080/10426507.2024.2424268
Samaneh Mohamadian , Ghasem Aghapour
Tandem and efficient conversion of alcohols, tetrahydropyranyl (THP) and trimethylsilyl (TMS) ethers as protected alcohols to oximes is described using a catalytic amount of nano Fe3O4 as a highly magnetic and nontoxic catalyst, tert-butyl hydroperoxide (TBHP) and hydroxylamine hydrochloride. The nanocatalyst is easily separated from the reaction medium using an external magnet and can be reused for several times without any considerable loss of its catalytic power. Also, it was found that it is possible to perform these oxidative conversions efficiently even in the presence of epoxides, carboxylic acids and esters, phenols, sulfides and pyridine rings with excellent chemoselectivity. The tandem and catalytic nature, catalyst reusability, high yields, and easy work up can be considered as the main advantages of the present environmentally friendly method.
{"title":"Nano Fe3O4 catalyzed selective, tandem, and oxidative conversion of alcohols, tetrahydropyranyl and trimethylsilyl ethers to oximes","authors":"Samaneh Mohamadian , Ghasem Aghapour","doi":"10.1080/10426507.2024.2424268","DOIUrl":"10.1080/10426507.2024.2424268","url":null,"abstract":"<div><div>Tandem and efficient conversion of alcohols, tetrahydropyranyl (THP) and trimethylsilyl (TMS) ethers as protected alcohols to oximes is described using a catalytic amount of nano Fe<sub>3</sub>O<sub>4</sub> as a highly magnetic and nontoxic catalyst, <em>tert</em>-butyl hydroperoxide (TBHP) and hydroxylamine hydrochloride. The nanocatalyst is easily separated from the reaction medium using an external magnet and can be reused for several times without any considerable loss of its catalytic power. Also, it was found that it is possible to perform these oxidative conversions efficiently even in the presence of epoxides, carboxylic acids and esters, phenols, sulfides and pyridine rings with excellent chemoselectivity. The tandem and catalytic nature, catalyst reusability, high yields, and easy work up can be considered as the main advantages of the present environmentally friendly method.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"199 7","pages":"Pages 783-794"},"PeriodicalIF":1.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143144712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-02DOI: 10.1080/10426507.2024.2419630
Forough Cheldavi , Mohammad Bakherad , Ali Keivanloo , Mohsen Nikpour
A mild and efficient synthesis of 1,4-disubstituted 1,2,3-triazole linked pyrimidines is reported using click reactions. These compounds were prepared by the reaction of 4-propargyl substituted 5-iodo-6-methyl-2(methylthio) pyrimidine with aryl and benzyl azides via copper-catalyzed azide-alkyne cycloaddition reactions in the presence of sodium ascorbate, as a reducing agent. Furthermore, the synthesized compounds were screened against the two bacterial strains pseudomonas aeruginosa and saphylococcus aureus.
{"title":"Synthesis of new 1,2,3-triazole-linked pyrimidines by click reaction","authors":"Forough Cheldavi , Mohammad Bakherad , Ali Keivanloo , Mohsen Nikpour","doi":"10.1080/10426507.2024.2419630","DOIUrl":"10.1080/10426507.2024.2419630","url":null,"abstract":"<div><div>A mild and efficient synthesis of 1,4-disubstituted 1,2,3-triazole linked pyrimidines is reported using click reactions. These compounds were prepared by the reaction of 4-propargyl substituted 5-iodo-6-methyl-2(methylthio) pyrimidine with aryl and benzyl azides <em>via</em> copper-catalyzed azide-alkyne cycloaddition reactions in the presence of sodium ascorbate, as a reducing agent. Furthermore, the synthesized compounds were screened against the two bacterial strains <em>pseudomonas aeruginosa</em> and <em>saphylococcus aureus</em>.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"199 7","pages":"Pages 725-731"},"PeriodicalIF":1.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143144709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-02DOI: 10.1080/10426507.2024.2408768
R. M. Eugin Nirmala , R. Racil Jeya Geetha
In this study Ag-doped ZnS nanostructures for antibacterial activity were prepared by means of a facile wet-chemical method. XRD study reveals a decrease in the intensity of XRD peaks and the presence of an additional peak for silver which further affirms the incorporation of silver ions in ZnS matrix. The synthesized 1% Ag-doped ZnS nanostructures have the average particle size distribution of 16.45 ± 0.13 nm based on the TEM image. The antimicrobial activity of pure ZnS and Ag-doped ZnS were evaluated against Staphylococcus aureus and Escherichia coli. The results show that the bacterial inhibition was enhanced due to the doping of Ag into ZnS matrix in contrast to ZnS. This results obtained from the antibacterial study could be capitalized to be administered as a potent antibacterial drug for biomedical application.
{"title":"Effect of Ag doping on the structural, morphological, optical and antibacterial activity of ZnS nanoparticles","authors":"R. M. Eugin Nirmala , R. Racil Jeya Geetha","doi":"10.1080/10426507.2024.2408768","DOIUrl":"10.1080/10426507.2024.2408768","url":null,"abstract":"<div><div>In this study Ag-doped ZnS nanostructures for antibacterial activity were prepared by means of a facile wet-chemical method. XRD study reveals a decrease in the intensity of XRD peaks and the presence of an additional peak for silver which further affirms the incorporation of silver ions in ZnS matrix. The synthesized 1% Ag-doped ZnS nanostructures have the average particle size distribution of 16.45 ± 0.13 nm based on the TEM image. The antimicrobial activity of pure ZnS and Ag-doped ZnS were evaluated against <em>Staphylococcus aureus</em> and <em>Escherichia coli</em>. The results show that the bacterial inhibition was enhanced due to the doping of Ag into ZnS matrix in contrast to ZnS. This results obtained from the antibacterial study could be capitalized to be administered as a potent antibacterial drug for biomedical application.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"199 7","pages":"Pages 577-585"},"PeriodicalIF":1.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143144735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-02DOI: 10.1080/10426507.2024.2424287
Yanyu Sun , Shendan Xia , Yuyan Xu , Yanmin Liu , Shuo Zhang , Zhiwei Chen
An efficient electrochemical transformation of alkynoates into 3-sulfonated coumarins under transition metal- and oxidant-free conditions at room temperature is reported. The reaction proceeded via a radical-triggered domino aryl sulfonylation/5-exo cyclization/ester migration process and allowed the synthesis of 3-sulfonylated coumarins with good functional group tolerance. The reaction can be extended to the synthesis of quinolinones by capturing the sulfonyl radical with alkyne amides in good yields.
{"title":"Electrochemical-mediated cascading radical cyclization of activated alkynes: creation of 3-sulfonated coumarins and quinolinones","authors":"Yanyu Sun , Shendan Xia , Yuyan Xu , Yanmin Liu , Shuo Zhang , Zhiwei Chen","doi":"10.1080/10426507.2024.2424287","DOIUrl":"10.1080/10426507.2024.2424287","url":null,"abstract":"<div><div>An efficient electrochemical transformation of alkynoates into 3-sulfonated coumarins under transition metal- and oxidant-free conditions at room temperature is reported. The reaction proceeded <em>via</em> a radical-triggered domino aryl sulfonylation/5-exo cyclization/ester migration process and allowed the synthesis of 3-sulfonylated coumarins with good functional group tolerance. The reaction can be extended to the synthesis of quinolinones by capturing the sulfonyl radical with alkyne amides in good yields.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"199 7","pages":"Pages 824-835"},"PeriodicalIF":1.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143144824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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