Phosphorus, Sulfur, and Silicon and the Related Elements最新文献_第2页

Investigating the impact of the fluorescence and anticancer activities of N-alkyl and alkyl-hydroxy methylphthalimide dithiocarbamates 研究n -烷基和烷基-羟基甲基邻苯二胺二硫代氨基甲酸酯对荧光和抗癌活性的影响

IF 1.6 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Phosphorus, Sulfur, and Silicon and the Related Elements

Pub Date : 2025-10-16 DOI: 10.1080/10426507.2025.2576130

Rupali Rastogi (Conceptualization Data curation Formal analysis Funding acquisition Investigation Methodology Project administration Resources Supervision Visualization Writing – original draft Writing – review & editing) , Neelam Tia (Data curation Writing – review & editing) , R. J. Butcher (Data curation Formal analysis Resources Software)

A simple and reliable spectroscopic technique has been established for determining the N-Alkyl and Alkyl-hydroxy methylphthalimide dithiocarbamate moiety using elemental analysis, ESI mass, IR,¹H, ¹³C NMR, DTA, and TGA analysis. The approach is based on the interaction between N-chloro-methylphthalimide and Alkyl and Alkyl-hydroxy dithiocarbamate moiety to produce stable colorless dithiocarbamate molecules L¹–L³. All three ligands exhibited fluorescence properties. The ligands L¹ C₁₃ H₁₄ N₂ O₃ S₂ and L² C₁₈H₂₄N₂O₂S₂ were characterized using the SC-XRD technique. L¹ crystallizes in the monoclinic space group P 21/c, with unit cell parameters a = 7.212(5) Å, b = 23.852(5) Å, c = 8.147(5) Å, α = 90.000(5)°, β = 94.365(5)°, γ = 90.000(5)°, and Z = 4. The ligand L² C₁₈H₂₄N₂O₂S₂ crystallizes in monoclinic space group P 21/c with unit cell parameters a = 17.8094(7) Å, b = 7.8671(3) Å, c = 13.6819(5) Å, α = 90°, β = 103.688(4)°, γ = 90°, Z = 4. β angle of L¹ is 94.365(5)°, lesser than that of L² which is 103.688(4)° due to the presence of two carbon atom in L¹ while L² it is having six carbon atoms which has resulted in stretching in bond angle. Bond angle of L¹ of N(2)-C(10)-S(1) formed at 113.23(13) whereas in L² bond angle of N(2)-C(10)-S(1) formed at 124.09(11). For L², there was disorder in the ethyl substituent, which was modeled with two equivalent conformations with occupancies of 0.561(2)/0.439(2). Anticancer activity of L¹–L³ was also tested in cell lines of Prostate PC-3, Lung HOP-62, Lung NCI-H226, and Lung A549.

采用元素分析、ESI质量、IR、1H、13C NMR、DTA和TGA分析，建立了一种简单可靠的测定n -烷基和烷基羟基甲基邻苯二酰亚胺二硫代氨基甲酸酯部分的光谱技术。该方法是基于n -氯甲基邻苯二胺与烷基和烷基羟基二硫氨基甲酸酯部分的相互作用，生成稳定的无色二硫氨基甲酸酯分子L1-L3。这三种配体均表现出荧光性质。用SC-XRD技术对配体L1 C13 H14 N2 O3 S2和L2 C18H24N2O2S2进行了表征。L1结晶的单斜晶体的空间群P 21 / c,晶胞参数= 7.212 (5),b = 23.852 (5) a, c = 8.147(5),α= 90.000(5)°,β= 94.365(5)°,γ= 90.000(5)°,Z = 4。配体L2 C18H24N2O2S2在单斜空间群p21 /c中结晶，晶胞参数a = 17.8094(7) Å， b = 7.8671(3) Å， c = 13.6819(5) Å， α = 90°，β = 103.688(4)°，γ = 90°，Z = 4。L1的β角为94.365(5)°，小于L2的103.688(4)°，这是由于L1中有2个碳原子，而L2中有6个碳原子，导致键角拉伸。N(2)-C(10)-S(1)的L1键角形成于113.23(13)，而N(2)-C(10)-S(1)的L2键角形成于124.09（11）。对于L2，乙基取代基存在无序性，用占位率为0.561(2)/0.439(2)的两个等效构象来模拟。在前列腺PC-3、肺HOP-62、肺NCI-H226和肺A549细胞系中也检测了L1-L3的抗癌活性。

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引用次数: 0

The deposition of highly oriented films of bismuth and single crystalline bismuth spheres from the OMCVD precursor tribenzyl bismuth (Bn3Bi) OMCVD前驱体三苄基铋（Bn3Bi）沉积高取向铋膜和单晶铋球

IF 1.6 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Phosphorus, Sulfur, and Silicon and the Related Elements

Pub Date : 2025-10-15 DOI: 10.1080/10426507.2025.2576131

Michael P. Remington, Jr (Conceptualization Data curation Formal analysis Investigation Methodology Validation Writing – original draft Writing – review & editing) , Philip Boudjouk (Funding acquisition Project administration Resources Supervision)

The low-pressure CVD (LPCVD) of bismuth films on glass substrates from tribenzyl bismuth (Bn₃Bi), where Bn = CH₂C₆H₅, is described. The films produced were generally continuous in nature and uniform in thickness with the continuity and thickness decreasing with distance of the substrate from that of the precursor. The films displayed preferred orientation dominated by the {012} reflections. Deposition on Si(100) leads to the formation of single crystalline bismuth spheres. The spherical, equiaxed grains are single crystalline in nature with only the {012} reflections giving rise to diffraction and accounting for 99.8% of the total diffraction intensity. This study represents the first example of Bi(012) heteroepitaxy by CVD methods.

介绍了以三苄基铋（Bn3Bi）为原料，Bn = CH2C6H5，在玻璃衬底上低压气相沉积（LPCVD）制备铋薄膜的方法。制备的薄膜本质上是连续的，厚度均匀，随着衬底与前驱体的距离的增加，薄膜的连续性和厚度逐渐减小。薄膜显示出以{012}反射为主的优先取向。在Si（100）上沉积可形成单晶铋球。球形等轴晶粒本质上是单晶，只有{012}反射产生衍射，占总衍射强度的99.8%。本研究是第一个用CVD方法制备Bi（012）异质外延的例子。

引用次数: 0

New synthesis of substituted benzo-sulfonyl-amidine derivatives via C-N cross-coupling reactions of carbodiimides, sodium arylsulfinates, and aryl halides 碳二亚胺、芳基亚磺酸钠和芳基卤化物C-N交叉偶联反应合成取代苯磺酰脒衍生物

IF 1.6 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Phosphorus, Sulfur, and Silicon and the Related Elements

Pub Date : 2025-10-13 DOI: 10.1080/10426507.2025.2574321

Manijeh Nematpour (Data curation Formal analysis Methodology Supervision Writing – original draft Writing – review & editing)

In this contribution, a direct and speedy approach for the synthesis of a series of novel functionalized benzo-sulfonyl-amidine derivatives via copper-catalyzed, one-pot, three-component, C-N cross-coupling reaction of various aryl halides, carbodiimides, and sulfinate salts has been developed. The reaction proceeds in DMF at room temperature with no need for any ligand. The use of simple and readily available starting materials, mild copper-catalytic reaction conditions, no column chromatography, the synthesis of 12 new compounds, and good yields (72–90%) are remarkable specifications of this protocol.

在这篇贡献中，通过铜催化，一锅，三组分，C-N交叉偶联反应，各种芳基卤化物，碳二亚胺和亚硫酸盐盐合成一系列新的功能化苯磺酰脒衍生物的直接和快速的方法。反应在室温下在DMF中进行，不需要任何配体。使用简单易得的原料，温和的铜催化反应条件，无需柱层析，合成了12个新化合物，收率高（72-90%），是该方案的显著特点。

引用次数: 0

Synthesis, X-ray crystal structures, spectroscopic characterization, DFT calculations, and molecular docking study of new N-(4-chlorobutanoyl)-N’-(2-, 3-, and 4-methoxyphenyl)thiourea derivatives 新型N-（4-氯丁醇基）-N ' -（2-、3-和4-甲氧基苯基）硫脲衍生物的合成、x射线晶体结构、光谱表征、DFT计算和分子对接研究

IF 1.6 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Phosphorus, Sulfur, and Silicon and the Related Elements

Pub Date : 2025-10-13 DOI: 10.1080/10426507.2025.2574290

Hamza M. Abosadiya (Conceptualization Data curation Formal analysis Investigation Methodology Project administration Resources Software Validation Visualization Writing – original draft Writing – review & editing) , El Hassane Anouar (Formal analysis Funding acquisition Investigation Methodology Resources Software Validation Visualization Writing – original draft Writing – review & editing) , Bohari M. Yamin (Conceptualization Investigation Supervision Validation Visualization Writing – original draft)

Herein, a series of new thiourea derivatives namely N-(4-chlorobutanoyl)-N’-(2-methoxy phenyl)thiourea (1a), N-(4-chlorobutanoyl)-N’-(3-methoxyphenyl)thiourea (1b) and N-(4-chloro butanoyl)-N’-(4-methoxyphenyl)thiourea(1c) have been synthesized and characterized by FT-IR,¹H and ¹³C NMR spectroscopic techniques. Single-crystal X-ray diffraction analysis revealed that 1a is monoclinic with P2₁/n space group, and 1b and 1c are triclinic with Pī space group. The isomerization effects of the methoxy groups in 1a-1c were significantly observed in crystal packing, the centrosymmetric dimer formed by a pair of N—H…S intermolecular hydrogen bonds in 1a and 1b isomers, while, in the 1c isomer, its crystal packing is linked by both N—H…O and N—H…S intermolecular hydrogen bonding interactions formed one-dimensional chains. DFT calculations have been implemented at the B3LYP/6-311++G(d,p) level of theory. The optimized geometrical parameters were compared with the experimental ones in the solid phase. NBO analysis reveals that the strongest donor-acceptor interactions correspond to electron donation between the lone pair (LP) on the thiourea nitrogen and the antibonding orbital π*_C=S in 1a-1c with energies in the range 56–90 kcal/mol. The molecular docking investigation is carried out to determine the inhibitory effect of the synthesized thiourea isomers against the COVID-19 coronavirus. The estimated binding energies between the 6LU7-main protease and 1a, 1b, and 1c isomers are −6.59, −6.87, and −6.74 kcal/mol, respectively.

本文合成了一系列新的硫脲衍生物N-（4-氯丁基）-N′-（2-甲氧基苯基）硫脲（1a）、N-（4-氯丁基）-N′-（3-甲氧基苯基）硫脲（1b）和N-（4-氯丁基）-N′-（4-甲氧基苯基）硫脲（1c），并通过FT-IR、1H和13C NMR技术对其进行了表征。单晶x射线衍射分析表明，1a为单斜晶，具有P21/n空间群；1b和1c为三斜晶，具有P21/n空间群。在1a和1b异构体中，中心对称二聚体由一对N-H…S分子间氢键形成，而在1c异构体中，其晶体填充由N-H…O和N-H…S分子间氢键相互作用形成一维链。DFT计算已在B3LYP/6-311++G（d,p）理论水平上实现。将优化后的几何参数与固相实验参数进行了比较。NBO分析表明，最强的供体-受体相互作用对应于硫脲氮上的孤对（LP）与1a-1c中的反键轨道π*C=S之间的电子捐赠，能量范围在56 ~ 90 kcal/mol之间。进行分子对接研究，确定合成的硫脲异构体对COVID-19冠状病毒的抑制作用。6lu7主蛋白酶与1a、1b和1c异构体的结合能分别为- 6.59、- 6.87和- 6.74 kcal/mol。

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引用次数: 0

Sodium sulfide promoted synthesis of highly substituted pyridines 硫化钠促进了高取代吡啶的合成

IF 1.6 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Phosphorus, Sulfur, and Silicon and the Related Elements

Pub Date : 2025-10-13 DOI: 10.1080/10426507.2025.2571645

Samira Darbidi (Data curation Investigation Methodology) , Bagher Mohammadi (Conceptualization Investigation Methodology Project administration Writing – original draft) , Ali Ramazani (Resources Supervision Validation) , Oskar Kaszubowski (Data curation Formal analysis) , Katarzyna Ślepokura (Data curation Formal analysis Software)

This study presents a straightforward and effective method for the synthesis of 2-amino-6-alkoxy-4-arylpyridine-3,5-dicarbonitrile derivatives. These multi-substituted pyridine compounds are prepared through a convenient pseudo three-component reaction involving arylaldehydes malononitrile, alcohols, and sodium sulfide in an aqueous medium. Key benefits of this approach include its environmentally friendly nature, high product yields, rapid reaction times, cost-effectiveness, and easy accessibility of starting materials, mild reaction conditions, and a simple purification process.

本研究提出了一种简单有效的合成2-氨基-6-烷氧基-4-芳基吡啶-3,5-二腈衍生物的方法。这些多取代吡啶化合物是通过在水介质中涉及芳醛、丙二腈、醇和硫化钠的方便的伪三组分反应制备的。该方法的主要优点包括其环保性，高产品收率，快速反应时间，成本效益，起始材料易于获取，反应条件温和，纯化过程简单。

引用次数: 0

Novel synthesis and anticancer screening of indole substituted thiosemicarbazone against HeLa, HCT-15 and U87-MG 吲哚取代硫代氨基脲的新合成及抗HeLa、HCT-15和U87-MG的抗癌筛选

IF 1.6 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Phosphorus, Sulfur, and Silicon and the Related Elements

Pub Date : 2025-10-10 DOI: 10.1080/10426507.2025.2571649

Salunke Kalidas Sopan (Data curation Investigation) , Abhishek Srivastava (Formal analysis) , Sachin Srivastava (Validation) , Ram Kishore (Methodology Supervision) , Nitin Srivastava (Writing – review & editing)

A novel series of indole thiosemicarbazone was designed, synthesized and screened for anticancer activities against cervical (HeLa), colon (HCT-15) and glioblastoma (U87-MG) cancer cells. Among the synthesized compounds, the compound 7h [(Z)-1-((1-(2-(trifluoromethoxy)benzyl)-1H-indol-3-yl)methylene)-4-tert-butyl-thiosemicarbazide] exhibited potential anticancer activities to all considered cell lines owing to its structural advantages, which were related to the electron-donating groups in the benzene rings. The compound 7h possessed the highest anticancer activities toward HeLa (IC₅₀=15.4 µM), HCT-15 (IC₅₀=36.8 µM) and U87-MG (IC₅₀=10.2 µM) with high specificity and lower toxicity to the normal cell line L929 (IC₅₀=225.8 µM), which is comparable to the standard anticancer drug Cisplatin. The compound 7h induced both intrinsic and extrinsic apoptosis in the cancer cells, which was confirmed by the cleavage of PARP, caspase 3 and caspase 9.

设计、合成了一系列新的吲哚硫代氨基脲酮，并对宫颈癌（HeLa）、结肠癌（HCT-15）和胶质母细胞瘤（U87-MG）癌细胞进行了抑癌活性筛选。在所合成的化合物中，化合物7h [(Z)-1-（（1-（2-（三氟甲氧基）苄基）- 1h -吲哚-3-基）亚甲基）-4-叔丁基硫代氨基脲]由于其结构优势，对所有考虑的细胞系都表现出潜在的抗癌活性，这与苯环上的给电子基团有关。化合物7h对HeLa （IC50=15.4µM）、HCT-15 （IC50=36.8µM）和U87-MG （IC50=10.2µM）具有最高的抗癌活性，对正常细胞系L929 （IC50=225.8µM）具有高特异性和低毒性，与标准抗癌药物顺铂相当。化合物7h可诱导肿瘤细胞内、外源性凋亡，通过裂解PARP、caspase 3和caspase 9证实。

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引用次数: 0

Synthesis, characterization, DFT, and molecular docking of 1,2,3,4-tetrahydro-isoquinoline/4-phenylpiperazine-sulfonyl benzamide derivatives as possible antidiabetic agents 1,2,3,4-四氢异喹啉/4-苯基哌嗪-磺酰基苯酰胺衍生物的合成、表征、DFT和分子对接

IF 1.6 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Phosphorus, Sulfur, and Silicon and the Related Elements

Pub Date : 2025-10-10 DOI: 10.1080/10426507.2025.2571644

Chafika Bougheloum (Conceptualization Formal analysis Investigation Methodology Software Supervision Validation Visualization Writing – original draft Writing – review & editing) , Soumaya Bouskia (Conceptualization Formal analysis Investigation Methodology Software Writing – original draft) , Samia Guezane Lakoud (Investigation Supervision Visualization Writing – original draft Writing – review & editing)

In this work, a straightforward and eco-friendly process has been adopted for the preparation of novel sulfonyl benzamides incorporating 1,2,3,4-tetrahydroisoquinoline and 4-phenylpiperazine moieties. The synthesis was efficiently carried out in a one-pot reaction using Preyssler heteropolyacid H₁₄[NaP₅W₃₀O₁₁₀] as a green, heterogeneous catalyst. This method afforded the target compounds in good yields of up to 88% by coupling selected benzoylating agents with sulfonamides under mild conditions. The structures of the synthesized products were confirmed by standard spectroscopic data (¹H NMR,¹³C NMR, and MS) and elemental analysis. Additionally, DFT calculations at the B3LYP/6–311G (d,p) level were employed to explore the electronic properties, reactivity, and stability of the compounds based on HOMO and LUMO energy values. In silico molecular docking studies were conducted to assess the binding interactions between the synthesized sulfonyl benzamide-heterocyclic compounds and the human glucokinase protein (PDB ID: 3IMX). All compounds demonstrated favorable binding affinities, with docking scores reaching up to −10.8 kcal/mol at the active site of 3IMX. These results suggest that the newly developed sulfonyl benzamide derivatives hold promise as potential antidiabetic agents. Furthermore, their pharmacokinetic properties were assessed through ADME/T predictions, providing additional insight into their drug-likeness and therapeutic potential.

在这项工作中，采用一种简单、环保的方法制备了含有1,2,3,4-四氢异喹啉和4-苯基哌嗪的新型磺酰苯酰胺。以Preyssler杂多酸H14[NaP5W30O110]为绿色非均相催化剂，在一锅反应中高效地进行了合成。该方法通过选择苯甲酰化剂与磺胺类化合物在温和条件下偶联，可获得收率高达88%的目标化合物。合成产物的结构通过标准波谱（1H NMR、13C NMR和MS）和元素分析得到证实。此外，利用B3LYP/ 6-311G （d,p）能级的DFT计算，基于HOMO和LUMO能值来探索化合物的电子性质、反应性和稳定性。在硅分子对接研究中，评估了合成的磺酰苯酰胺杂环化合物与人葡萄糖激酶蛋白（PDB ID: 3IMX）之间的结合相互作用。所有化合物均表现出良好的结合亲和性，在3IMX活性位点的对接分数高达−10.8 kcal/mol。这些结果表明，新开发的磺酰苯甲酰胺衍生物有望成为潜在的抗糖尿病药物。此外，通过ADME/T预测评估了它们的药代动力学特性，为它们的药物相似性和治疗潜力提供了额外的见解。

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引用次数: 0

Synthesis and biological assessment of Schiff base metal complexes: In vitro anticancer activity and computational insights 希夫贱金属配合物的合成和生物学评价：体外抗癌活性和计算见解

IF 1.6 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Phosphorus, Sulfur, and Silicon and the Related Elements

Pub Date : 2025-10-06 DOI: 10.1080/10426507.2025.2571651

Manu M. B. (Writing – original draft) , Deepika P. (Software) , Srikantamurthy N. (Methodology) , Vinusha H. M. (Methodology) , Madan S. M. (Software) , Shiva Prasad K. (Resources) , Chandan S. (Methodology) , K. B. Umesha (Supervision)

This study investigates the synthesis and characterization of a novel Schiff base ligand, (PCTA), derived from 2-Amino-4-chlorobenzothiazole and Pyrrole-2-carboxaldehyde, and its transition metal complexes with Cu(II), Co(II), Ni(II), Mn(II), and Zn(II) forming a monomeric complex of the type [Cu(L)₂]. Structural characterization of the ligand and its metal complexes was carried out using FT-IR, UV-Visible, LC-MS,¹H NMR, ESR, and thermal analysis (TG/DTG), confirming the formation of stable coordination compounds. Molecular docking studies revealed strong binding interactions with key cancer-related target proteins, with binding affinities ranging from −5.5 to −9.1 kcal/mol, where the free ligand showed a binding affinity of −5.5 kcal/mol, while the Copper(II) complex exhibited the highest affinity at −9.1 kcal/mol, highlighting its potential for therapeutic development. Using Swiss-ADME and pkCSM tools, ADMET profiling predicted favorable pharmacokinetic properties, with oral bioavailability over 60% and the ability to cross the blood-brain barrier, crucial for cancer treatment. The biological activity of the complexes was further predicted using the PASS program, with promising results suggesting significant pharmacological potential. In vitro cytotoxicity tests, using the sulforhodamine-B (SRB) assay, demonstrated a significant reduction in cell viability, highlighting the compounds’ strong anticancer potential. The Cu(II) complex had the highest cytotoxicity activity among the tested compounds against human colorectal adenocarcinoma cell line (HT-29) and Human breast adenocarcinoma cell line (MDA-MB-231) with IC₅₀ values of 0.26 and 0.06 µg/mL respectively. These findings underscore the therapeutic promise of the synthesized complexes.

本研究研究了一种新型希夫碱配体（PCTA）的合成和表征，该配体由2-氨基-4-氯苯并噻唑和吡咯-2-甲醛衍生而来，其过渡金属配合物与Cu(II), Co(II), Ni(II), Mn（II）和Zn（II）形成单体配合物[Cu(L)2]。利用FT-IR、UV-Visible、LC-MS、1H NMR、ESR和热分析（TG/DTG）对配体及其金属配合物进行了结构表征，证实了其形成了稳定的配位化合物。分子对接研究显示，与关键的癌症相关靶蛋白具有强的结合相互作用，结合亲和力范围为- 5.5至- 9.1 kcal/mol，其中自由配体的结合亲和力为- 5.5 kcal/mol，而铜（II）复合物的亲和力最高，为- 9.1 kcal/mol，突出了其治疗开发的潜力。使用Swiss-ADME和pkCSM工具，ADMET分析预测了良好的药代动力学特性，口服生物利用度超过60%，能够穿过血脑屏障，这对癌症治疗至关重要。利用PASS程序进一步预测了复合物的生物活性，结果表明具有重要的药理潜力。体外细胞毒性试验，使用硫代磺胺- b （SRB）测定，显示细胞活力显著降低，突出化合物的强大抗癌潜力。其中Cu（II）复合物对人结直肠癌腺细胞株HT-29和人乳腺腺细胞株MDA-MB-231的细胞毒活性最高，IC50值分别为0.26和0.06µg/mL。这些发现强调了合成复合物的治疗前景。

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引用次数: 0

Exploring the therapeutic potential of diorganotin(IV) complexes derived from hydrazone ligands: synthesis, characterization, DFT study, and biological evaluation 探索由腙配体衍生的双有机锡（IV）配合物的治疗潜力：合成、表征、DFT研究和生物学评价

IF 1.6 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Phosphorus, Sulfur, and Silicon and the Related Elements

Pub Date : 2025-10-03 DOI: 10.1080/10426507.2025.2568493

Shikha Poonia (Conceptualization Data curation Formal analysis Investigation Methodology Validation Writing – original draft) , Sonika Asija (Formal analysis Supervision Validation) , Kashmiri Lal (Formal analysis Validation) , Yogesh Deswal (Software) , Jagat Singh Kirar (Software) , Pinki Barwa (Formal analysis) , Anju Ragshaniya (Formal analysis)

With the aim to explore potential drugs against tuberculosis and microbial infections, eight diorganotin(IV) complexes were synthesized from 4-nitro-3-methylbenzhydrazide. Various techniques, including NMR, FT-IR, and mass spectrometry, were used to fully characterize the compounds (1–10). Further, DFT studies were conducted with the help of Gaussian 09 software for compounds to get an insight for their biological potential by employing quantum mechanical principles. The evaluation of anti-tuberculosis results revealed that compounds 6 and 10 exhibited the highest potential to inhibit TB infections, having minimum inhibition concentration (MIC) values of 0.0194 ± 0.0004 and 0.0195 ± 0.0005 µmol/mL, respectively. Results of anti-microbial analysis revealed that compound 6 showed the highest efficacy against tested microbes with MIC values around 0.0194 ± 0.0048 µmol/mL.

以4-硝基-3-甲基苯并肼为原料，合成了8种双有机锡配合物，以探索抗结核和微生物感染的潜在药物。各种技术，包括NMR， FT-IR和质谱，被用来全面表征化合物（1-10）。此外，利用Gaussian 09软件对化合物进行DFT研究，利用量子力学原理了解其生物潜力。抗结核评价结果显示，化合物6和10的最低抑制浓度（MIC）分别为0.0194±0.0004和0.0195±0.0005µmol/mL，抑制结核感染的潜力最大。抗菌分析结果显示，化合物6的MIC值在0.0194±0.0048µmol/mL左右，抗菌效果最好。

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引用次数: 0

The synthesis of InSb powders and deposition of InSb films from the new organometallic CVD (OMCVD) precursors tribenzyl indium (Bn3In) and tribenzyl antimony (Bn3Sb) 新型有机金属CVD （OMCVD）前驱体三苄基铟（Bn3In）和三苄基锑（Bn3Sb）制备InSb粉末及InSb薄膜

IF 1.6 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Phosphorus, Sulfur, and Silicon and the Related Elements

Pub Date : 2025-10-03 DOI: 10.1080/10426507.2025.2568490

Michael P. Remington (Conceptualization Data curation Formal analysis Investigation Methodology Validation Writing – original draft Writing – review & editing) , Philip Boudjouk (Funding acquisition Project administration Resources Supervision)

The condensed phase pyrolysis between tribenzyl indium (Bn₃In) and tribenzyl antimony (Bn₃Sb) at 350 °C and 1 atmosphere of N₂ in a 1:1 molar ratio produces highly crystalline InSb powders. These powders contain Sb, In and In₂O₃ as crystalline impurities. The reaction likely proceeds by way of adduct formation between the two compounds, followed by loss of 1,2-diphenyl ethane (bibenzyl). Low-pressure CVD (LPCVD) experiments on glass substrates lead to the formation of polycrystalline InSb films with low carbon contamination at 300 °C. This growth temperature nearly matches the lowest growth temperature obtained with any antimony precursor.

三苄基铟（Bn3In）和三苄基锑（Bn3Sb）在350℃和1个气氛的N2中以1:1的摩尔比进行凝聚态热解，得到高结晶的InSb粉末。这些粉末含有Sb、In和In2O3等晶体杂质。反应可能是通过两种化合物之间的加合物形成进行的，然后是1,2-二苯乙烷（联苯）的损失。在300°C下，在玻璃衬底上进行低压CVD （LPCVD）实验，形成了低碳污染的多晶InSb薄膜。这个生长温度几乎与任何锑前驱体的最低生长温度相匹配。

引用次数: 0