Pub Date : 2024-09-02DOI: 10.1080/10426507.2024.2420011
Manchikanti M. Chandrasekhar , D. S. Ramakrishna , Priyanka Behera , Bhujanga Rao Chitturi
The present work reports the synthesis of 2-vinylpyridine in multigram synthetic approach as it has tremendous application in pharmaceutical science as well as in material science and industries. This present method emphasizes the usage of commercially available inexpensive raw materials and bio renewable solvents. Nontoxic TCCA was used as green chlorinating reagent and its corresponding bi-product obtained in the course of the reaction is biodegradable in nature. This entire three step procedure does not require any chromatographic techniques and the product is obtained in 95% yield with > 98% purity.
{"title":"Multigram synthesis of 2-vinylpyridine using bio-renewable 2-methyl tetrahydrofuran solvent","authors":"Manchikanti M. Chandrasekhar , D. S. Ramakrishna , Priyanka Behera , Bhujanga Rao Chitturi","doi":"10.1080/10426507.2024.2420011","DOIUrl":"10.1080/10426507.2024.2420011","url":null,"abstract":"<div><div>The present work reports the synthesis of 2-vinylpyridine in multigram synthetic approach as it has tremendous application in pharmaceutical science as well as in material science and industries. This present method emphasizes the usage of commercially available inexpensive raw materials and bio renewable solvents. Nontoxic TCCA was used as green chlorinating reagent and its corresponding bi-product obtained in the course of the reaction is biodegradable in nature. This entire three step procedure does not require any chromatographic techniques and the product is obtained in 95% yield with > 98% purity.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"199 7","pages":"Pages 767-770"},"PeriodicalIF":1.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143144234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-02DOI: 10.1080/10426507.2024.2408774
Manokari Mani , Mohammad Faisal , Abdulrahman A. Alatar , Mahipal S. Shekhawat
Silicon nanoparticles (SiNPs) improve plant growth and yield by enhancing nutrient uptake and stress tolerance. These nanoparticles boost plant defense mechanisms against pathogens and environmental challenges. In this study, seedlings-derived explants of white-fleshed dragon fruit (Selenicereus undatus) were used for differentiation and high-frequency shoot regeneration on Murashige and Skoog (MS) medium with 6-benzylaminopurine (BAP, 0.5 mg L−1) and α-naphthalene acetic acid (NAA, 0.25 mg L−1). The complementation of 3.0 mg L−1 SiNPs in the optimized nutrient medium enhanced the shoot multiplication rate to 23.0 cladodes per explants. The regenerated cladodes were structurally well-suited with thick cuticles, well-developed epidermis, hypodermis, aquiferous cortex, and collateral vascular bundles compared to the control and other concentrations of SiNPs tested. SiNPs promoted the development of 3-5 aerial and adventitious roots per cladode enabling preferred direct hardening of cloned plants on soilrite ex vitro. The morphological transformations improved by SiNPs, including the formation of robust cladode and spines, played a pivotal role in achieving a high rate of acclimatization success (96%) in the field. The incorporation of SiNPs in vitro at the shoot amplification stage of micropropagation of S. undatus induced morphogenesis and structural changes, and promoted qualitative and quantitative improvements in the regenerated cladodes which helped in enhanced survival of plants in vivo.
{"title":"Silicon nanoparticle(s) induced morpho-anatomical traits and improved micropropagation of white fleshed dragon fruit [Selenicereus undatus (Haworth)]","authors":"Manokari Mani , Mohammad Faisal , Abdulrahman A. Alatar , Mahipal S. Shekhawat","doi":"10.1080/10426507.2024.2408774","DOIUrl":"10.1080/10426507.2024.2408774","url":null,"abstract":"<div><div>Silicon nanoparticles (SiNPs) improve plant growth and yield by enhancing nutrient uptake and stress tolerance. These nanoparticles boost plant defense mechanisms against pathogens and environmental challenges. In this study, seedlings-derived explants of white-fleshed dragon fruit (<em>Selenicereus undatus</em>) were used for differentiation and high-frequency shoot regeneration on Murashige and Skoog (MS) medium with 6-benzylaminopurine (BAP, 0.5 mg L<sup>−1</sup>) and α-naphthalene acetic acid (NAA, 0.25 mg L<sup>−1</sup>). The complementation of 3.0 mg L<sup>−1</sup> SiNPs in the optimized nutrient medium enhanced the shoot multiplication rate to 23.0 cladodes per explants. The regenerated cladodes were structurally well-suited with thick cuticles, well-developed epidermis, hypodermis, aquiferous cortex, and collateral vascular bundles compared to the control and other concentrations of SiNPs tested. SiNPs promoted the development of 3-5 aerial and adventitious roots per cladode enabling preferred direct hardening of cloned plants on soilrite <em>ex vitro</em>. The morphological transformations improved by SiNPs, including the formation of robust cladode and spines, played a pivotal role in achieving a high rate of acclimatization success (96%) in the field. The incorporation of SiNPs <em>in vitro</em> at the shoot amplification stage of micropropagation of <em>S. undatus</em> induced morphogenesis and structural changes, and promoted qualitative and quantitative improvements in the regenerated cladodes which helped in enhanced survival of plants <em>in vivo</em>.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"199 7","pages":"Pages 598-606"},"PeriodicalIF":1.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143144710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-02DOI: 10.1080/10426507.2024.2410867
Cemre Avşar , Suna Ertunç
Phosphogypsum (PG), a by-product of phosphate fertilizer industry, is chemically impure gypsum (CaSO4 · 2 H2O) containing phosphate residues. Provided by the calcium and phosphorus content, PG can be considered as a precursor for synthetic hydroxyapatite (s-HAp) production. This study proposes a two-step alkali route for s-HAp production from PG. Resulting samples were characterized by ICP-OES, SEM, XRD and FT-IR analyses in comparison with bone ash (BA) sample. Ca/P ratio (wt%) was determined as 2.46 and 2.78 for s-HAp and BA samples, respectively. SEM analysis showed the uniform distribution of spherical shaped particles in BA samples; however s-HAp particles showed irregular distribution of nearly spherical-like particles agglomerated as platelets on the surface. XRD analysis indicated that s-HAp particles possessed low crystallinity and ICDD references showed the appearance of apatite-CaOH phases. FT-IR spectrum showed the vibration bands of PO43− bands in the range of 1018–601 cm−1. According to characterization analyses, s-HAp samples show lower Ca/P ratio, irregular morphology, and low crystallinity due to possible impurities. Thus, further downstream operations regarding to impurity removal should be employed to develop a promising route to synthetic HAp production and employ a CE approach on industrial scale to evaluate s-HAp samples as a commercial substitute to BA.
{"title":"A novel process approach of a circular economy practice in the production of hydroxyapatite from phosphogypsum","authors":"Cemre Avşar , Suna Ertunç","doi":"10.1080/10426507.2024.2410867","DOIUrl":"10.1080/10426507.2024.2410867","url":null,"abstract":"<div><div>Phosphogypsum (PG), a by-product of phosphate fertilizer industry, is chemically impure gypsum (CaSO<sub>4</sub> · 2 H<sub>2</sub>O) containing phosphate residues. Provided by the calcium and phosphorus content, PG can be considered as a precursor for synthetic hydroxyapatite (s-HAp) production. This study proposes a two-step alkali route for s-HAp production from PG. Resulting samples were characterized by ICP-OES, SEM, XRD and FT-IR analyses in comparison with bone ash (BA) sample. Ca/P ratio (wt%) was determined as 2.46 and 2.78 for s-HAp and BA samples, respectively. SEM analysis showed the uniform distribution of spherical shaped particles in BA samples; however s-HAp particles showed irregular distribution of nearly spherical-like particles agglomerated as platelets on the surface. XRD analysis indicated that s-HAp particles possessed low crystallinity and ICDD references showed the appearance of apatite-CaOH phases. FT-IR spectrum showed the vibration bands of PO<sub>4</sub><sup>3−</sup> bands in the range of 1018–601 cm<sup>−1</sup>. According to characterization analyses, s-HAp samples show lower Ca/P ratio, irregular morphology, and low crystallinity due to possible impurities. Thus, further downstream operations regarding to impurity removal should be employed to develop a promising route to synthetic HAp production and employ a CE approach on industrial scale to evaluate s-HAp samples as a commercial substitute to BA.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"199 7","pages":"Pages 628-634"},"PeriodicalIF":1.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143144730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-02DOI: 10.1080/10426507.2024.2416211
Soumaya Bouskia , Chafika Bougheloum
An adequate method is described for the synthesis of new substituted benzamides containing a sulfonamide moiety using Preyssler heteropolyacid H14[NaP5W30O110] as an efficient catalyst. This method proceeds in one-step, including deprotection and benzoylation of N-(tert-butoxycarbonyl) sulfonamides to give the target compounds good yields (up to 92%). A molecular docking was performed to study the interactions between the synthesized benzamides and human carbonic anhydrases II. It was concluded that all compounds demonstrated good binding score values (up to −9.4 kcal/mol) for the active site of all selected proteins when compared with the reference drug Acetazolamide (−6.3 kcal/mol). In addition, the ADME/T analyses show that all synthesized molecules exhibited good pharmacokinetics and bioavailability. The theoretical calculations for all compounds were performed using the DFT/B3LYP/6–31G (d,p) level of theory. The study yielded optimized structural parameters, global reactivity descriptors, and Frontier Molecular Orbitals (FMO’s).
{"title":"Preyssler heteropolyacid-mediated direct deprotection/N-benzoylation of N-Boc-protected sulfonamides: synthesis, molecular docking, DFT study and in-silico ADME evaluation of novel benzamides bearing the sulfonamide moiety as possible inhibitors of human carbonic anhydrase II","authors":"Soumaya Bouskia , Chafika Bougheloum","doi":"10.1080/10426507.2024.2416211","DOIUrl":"10.1080/10426507.2024.2416211","url":null,"abstract":"<div><div>An adequate method is described for the synthesis of new substituted benzamides containing a sulfonamide moiety using Preyssler heteropolyacid H<sub>14</sub>[NaP<sub>5</sub>W<sub>30</sub>O<sub>110</sub>] as an efficient catalyst. This method proceeds in one-step, including deprotection and benzoylation of <em>N</em>-(tert-butoxycarbonyl) sulfonamides to give the target compounds good yields (up to 92%). A molecular docking was performed to study the interactions between the synthesized benzamides and human carbonic anhydrases II. It was concluded that all compounds demonstrated good binding score values (up to −9.4 kcal/mol) for the active site of all selected proteins when compared with the reference drug Acetazolamide (−6.3 kcal/mol). In addition, the ADME/T analyses show that all synthesized molecules exhibited good pharmacokinetics and bioavailability. The theoretical calculations for all compounds were performed using the DFT/B3LYP/6–31G (d,p) level of theory. The study yielded optimized structural parameters, global reactivity descriptors, and Frontier Molecular Orbitals (FMO’s).</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"199 7","pages":"Pages 683-697"},"PeriodicalIF":1.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143144838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-02DOI: 10.1080/10426507.2024.2410864
Cheng-lu Zhang , Jing-hao Guo , Yang Zhang , Lu Zhang , Chang Liu , Shi-ru Nie
A novel fluorescent probe (BPQ-1) with large conjugated system (phenothiazine was conjugated with quinazolinone) was synthesized. BPQ-1 showed a remarkable ratiometric fluorescence response to ClO− within 10 s, and achieved large stokes shift (168 nm), high sensitivity (LOD = 16.7 nM) and excellent selectivity. Among the analytes to be detected, there is a significant change from bright yellow fluorescence to cyan fluorescence only when ClO− is added to BPQ-1. Through density functional theory calculation and mass spectrometry experiments, the fluorescence response mechanisms of the BPQ-1 are given. In addition, BPQ-1 has been successfully applied to the detection of ClO− in real water samples and test strips for detecting ClO− with different concentrations have been prepared. In particular, the probe has been successfully applied to the fluorescence imaging of exogenous ClO− in living cells.
{"title":"A ratiometric fluorescent probe based on phenothiazine and quinazolinone for rapid detection of ClO− and its application","authors":"Cheng-lu Zhang , Jing-hao Guo , Yang Zhang , Lu Zhang , Chang Liu , Shi-ru Nie","doi":"10.1080/10426507.2024.2410864","DOIUrl":"10.1080/10426507.2024.2410864","url":null,"abstract":"<div><div>A novel fluorescent probe (<strong>BPQ-1</strong>) with large conjugated system (phenothiazine was conjugated with quinazolinone) was synthesized. <strong>BPQ-1</strong> showed a remarkable ratiometric fluorescence response to ClO<sup>−</sup> within 10 s, and achieved large stokes shift (168 nm), high sensitivity (LOD = 16.7 nM) and excellent selectivity. Among the analytes to be detected, there is a significant change from bright yellow fluorescence to cyan fluorescence only when ClO<sup>−</sup> is added to <strong>BPQ-1</strong>. Through density functional theory calculation and mass spectrometry experiments, the fluorescence response mechanisms of the <strong>BPQ-1</strong> are given. In addition, <strong>BPQ-1</strong> has been successfully applied to the detection of ClO<sup>−</sup> in real water samples and test strips for detecting ClO<sup>−</sup> with different concentrations have been prepared. In particular, the probe has been successfully applied to the fluorescence imaging of exogenous ClO<sup>−</sup> in living cells.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"199 7","pages":"Pages 619-627"},"PeriodicalIF":1.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143144731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-02DOI: 10.1080/10426507.2024.2410870
Wenhe Yu , Xiaowen Wu , Dingyi Zhang , Ruiyu Mi , Minghao Fang , Xin Min , Zhaohui Huang
In this work, single-phase ZSM-5 zeolite was synthesized using solid waste coal fly ash (CFA) as raw material, providing a potential alternative for creating high-value-added products from this waste. X-ray diffraction (XRD), scanning electron microscopy, X-ray fluorescence, Fourier transform infrared spectroscopy, N2 physisorption, and other techniques were used to evaluate the crystallization and morphology of the ZSM-5 obtained. The results indicated that ZSM-5 can be synthesized by the simple method of mixing, stirring, and heating. A well-defined hexagonal shape of ZSM-5 with a specific surface area of 162 m2/g and mesoporous structure was obtained at the temperature of 160 °C during hydrothermal treatment for 72 h. Theoretically, the mechanism of crystal growth of ZSM-5, i.e. the liquid phase nucleation and step growth models, was clarified. These results open the possibility of exploring the crystallization of ZSM-5 and the utilization of CFA. Simultaneously, the critical roles of silicon in framework formation and crystallization control during the formation and growth of zeolites were elucidated.
{"title":"Role of silicon in the growth of ZSM-5 synthesized with coal fly ash as raw materials","authors":"Wenhe Yu , Xiaowen Wu , Dingyi Zhang , Ruiyu Mi , Minghao Fang , Xin Min , Zhaohui Huang","doi":"10.1080/10426507.2024.2410870","DOIUrl":"10.1080/10426507.2024.2410870","url":null,"abstract":"<div><div>In this work, single-phase ZSM-5 zeolite was synthesized using solid waste coal fly ash (CFA) as raw material, providing a potential alternative for creating high-value-added products from this waste. X-ray diffraction (XRD), scanning electron microscopy, X-ray fluorescence, Fourier transform infrared spectroscopy, N<sub>2</sub> physisorption, and other techniques were used to evaluate the crystallization and morphology of the ZSM-5 obtained. The results indicated that ZSM-5 can be synthesized by the simple method of mixing, stirring, and heating. A well-defined hexagonal shape of ZSM-5 with a specific surface area of 162 m<sup>2</sup>/g and mesoporous structure was obtained at the temperature of 160 °C during hydrothermal treatment for 72 h. Theoretically, the mechanism of crystal growth of ZSM-5, i.e. the liquid phase nucleation and step growth models, was clarified. These results open the possibility of exploring the crystallization of ZSM-5 and the utilization of CFA. Simultaneously, the critical roles of silicon in framework formation and crystallization control during the formation and growth of zeolites were elucidated.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"199 7","pages":"Pages 647-653"},"PeriodicalIF":1.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143144738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-02DOI: 10.1080/10426507.2024.2420006
Farinaz Kamali , Mohammad Abdollahi Alibeik , Zeinab Hamidi
Herein, the synthesis of 2-amino-3,5-dicyano-6-sulfanyl pyridine derivatives has been studied due to wide applications of highly substituted pyridines. At first, Hydrotalcite (HT) with various loading amounts of lanthanum (HT-La) was synthesized. Then, their catalytic activities were investigated for the condensation reaction of benzaldehyde, malononitrile, and thiophenol under reflux condition as a model reaction. The prepared HT nanocatalyst with 10 mol% of La showed the best performance in this multicomponent reaction. In addition, the reusability of the nanocatalyst was studied and the results showed, that the prepared nanocatalyst could be reused several times with an only moderate decrease in activity. Subsequently, HT-La (10 mol%) efficiently catalyzed the one-pot condensation reaction for the synthesis of highly substituted pyridines under reflux conditions. The products were produced with excellent yields, short reaction times, and easy recyclability of the nanocatalyst.
{"title":"Multicomponent one pot synthesis of substituted pyridines with a highly active and recyclable hydrotalcite-lanthanum nanocatalyst","authors":"Farinaz Kamali , Mohammad Abdollahi Alibeik , Zeinab Hamidi","doi":"10.1080/10426507.2024.2420006","DOIUrl":"10.1080/10426507.2024.2420006","url":null,"abstract":"<div><div>Herein, the synthesis of 2-amino-3,5-dicyano-6-sulfanyl pyridine derivatives has been studied due to wide applications of highly substituted pyridines. At first, Hydrotalcite (HT) with various loading amounts of lanthanum (HT-La) was synthesized. Then, their catalytic activities were investigated for the condensation reaction of benzaldehyde, malononitrile, and thiophenol under reflux condition as a model reaction. The prepared HT nanocatalyst with 10 mol% of La showed the best performance in this multicomponent reaction. In addition, the reusability of the nanocatalyst was studied and the results showed, that the prepared nanocatalyst could be reused several times with an only moderate decrease in activity. Subsequently, HT-La (10 mol%) efficiently catalyzed the one-pot condensation reaction for the synthesis of highly substituted pyridines under reflux conditions. The products were produced with excellent yields, short reaction times, and easy recyclability of the nanocatalyst.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"199 7","pages":"Pages 746-755"},"PeriodicalIF":1.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143144233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-02DOI: 10.1080/10426507.2024.2416215
Abdoul Razak Halidou Dougourikoye , Mina Hariri , Jean-Noël Volle , Amadou Tidjani Ilagouma , Moussa Idrissa , Fatemeh Darvish , Jean Luc Pirat , David Virieux
Functionalized ionic liquids, commonly referred to as task-specific ionic liquids (TSILs), represent a distinct subset within the realm of ILs. They stand out by having a functional group covalently bonded to either the cationic or the anionic counterpart of the ionic liquid. These tailored modifications confer specific properties to TSILs, making them well-suited for various applications, including catalysis, liquid–liquid extraction, and synthesis. Notably, they also find relevance in the field of nanomaterials. In this paper, we delineate the synthetic pathway for TSILs featuring imidazolinium or pyridinium cores functionalized with a bisphosphonate unit. Furthermore, we provide detailed insights into the green synthesis of imidazolinium salts constituted by a bisphosphonate moiety as the counterion. These innovative TSILs, characterized by a bisphosphonate group, pave the way for a new avenue in the selective complexation of strategic metals and the development of new drugs.1 This underscores their potential utility in strategic metal recovery by extraction and related endeavors.
{"title":"Bisphosphonate salts as covalent and non-covalent task-specific ionic liquid synthesis","authors":"Abdoul Razak Halidou Dougourikoye , Mina Hariri , Jean-Noël Volle , Amadou Tidjani Ilagouma , Moussa Idrissa , Fatemeh Darvish , Jean Luc Pirat , David Virieux","doi":"10.1080/10426507.2024.2416215","DOIUrl":"10.1080/10426507.2024.2416215","url":null,"abstract":"<div><div>Functionalized ionic liquids, commonly referred to as task-specific ionic liquids (TSILs), represent a distinct subset within the realm of ILs. They stand out by having a functional group covalently bonded to either the cationic or the anionic counterpart of the ionic liquid. These tailored modifications confer specific properties to TSILs, making them well-suited for various applications, including catalysis, liquid–liquid extraction, and synthesis. Notably, they also find relevance in the field of nanomaterials. In this paper, we delineate the synthetic pathway for TSILs featuring imidazolinium or pyridinium cores functionalized with a bisphosphonate unit. Furthermore, we provide detailed insights into the green synthesis of imidazolinium salts constituted by a bisphosphonate moiety as the counterion. These innovative TSILs, characterized by a bisphosphonate group, pave the way for a new avenue in the selective complexation of strategic metals and the development of new drugs.<span><span><sup>1</sup></span></span> This underscores their potential utility in strategic metal recovery by extraction and related endeavors.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"199 7","pages":"Pages 698-703"},"PeriodicalIF":1.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143144839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Researchers have shown that sulfur-based heterocyclic frameworks form the backbone of a wide variety of synthetic analogues with a wide variety of medicinal actions. In this study, Passerini 3-component condensation reaction (P-3-CCR) approach has been used for the design strategy for imparting sulfur-based starting material, synthesis and antioxidant potential of sulfur containing pyrimidine (α-acyloxy amide) derivatives. The thorough assessment of antioxidant activities with a reference drug allows a proficient assessment of the structure–activity relationships (SARs) of the diversely synthesized molecules of the series. Compounds 4f with 3,4-(OMe)2 [17.35 ± 0.14 µM] and 4h with 4-NO2 [19.21 ± 0.14 µM] functionalities were identified as lead scaffolds with minimum IC50 values. A molecular docking investigation was also performed to compute the binding free energy of 4h and 4f to 1F9G. The results revealed a strong binding affinity (-7.1 kcal/mol) of both compounds as compared to that of ascorbic acid (-6.2 kcal/mol). A design strategy though molecular docking followed by MCRs approach to identify new α-acyloxy amides provided an outstanding approximation and shedded light on the sites of binding for their better use in medicinal field.
{"title":"Design, synthesis and antioxidant studies of thiopyrimidine-based Passerini reaction: sulfur linked derivatives","authors":"Mahesh Rupapara , Jignesh Kamdar , Jyoti Kuchhadiya , Mehul Chauhan , Abdullah Alarifi , Khushal Kapadiya","doi":"10.1080/10426507.2024.2419619","DOIUrl":"10.1080/10426507.2024.2419619","url":null,"abstract":"<div><div>Researchers have shown that sulfur-based heterocyclic frameworks form the backbone of a wide variety of synthetic analogues with a wide variety of medicinal actions. In this study, Passerini 3-component condensation reaction (P-3-CCR) approach has been used for the design strategy for imparting sulfur-based starting material, synthesis and antioxidant potential of sulfur containing pyrimidine (α-acyloxy amide) derivatives. The thorough assessment of antioxidant activities with a reference drug allows a proficient assessment of the structure–activity relationships (SARs) of the diversely synthesized molecules of the series. Compounds <strong>4f</strong> with 3,4-(OMe)<sub>2</sub> [17.35 ± 0.14 µM] and <strong>4h</strong> with 4-NO<sub>2</sub> [19.21 ± 0.14 µM] functionalities were identified as lead scaffolds with minimum IC<sub>50</sub> values. A molecular docking investigation was also performed to compute the binding free energy of <strong>4h</strong> and <strong>4f</strong> to <strong>1F9G</strong>. The results revealed a strong binding affinity (-7.1 kcal/mol) of both compounds as compared to that of ascorbic acid (-6.2 kcal/mol). A design strategy though molecular docking followed by MCRs approach to identify new α-acyloxy amides provided an outstanding approximation and shedded light on the sites of binding for their better use in medicinal field.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"199 7","pages":"Pages 704-711"},"PeriodicalIF":1.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143144823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-02DOI: 10.1080/10426507.2024.2402722
Fereshteh Khorasani , Mohammad Reza Islami , Hojatollah Khabazzadeh , Moj Khaleghi
A straightforward and efficient method for synthesizing 1,8-dioxo-decahydroacridine derivatives is presented, utilizing a one-pot, three-component condensation reaction involving dimedone, sulfamethoxazole, and aromatic aldehydes. The primary objective of this synthesis is to incorporate the sulfamethoxazole ring into the acridine family structure and examine the antibacterial effects and fluorescence properties of the compounds. The antibacterial activity of the synthesized compounds was evaluated against various gram-positive and gram-negative microorganisms, as well as a fungal strain, using the disk diffusion method, minimum inhibitory concentration determination, and bactericidal assays. Notably, five compounds exhibited potent antibacterial activity against both strains of Bacillus cereus. Furthermore, the influence of pH on the fluorescence emission intensity and absorption spectrum of the synthesized compounds was investigated, revealing that all products displayed fluorescence radiation.
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