Pub Date : 2025-07-03DOI: 10.1080/10426507.2025.2524191
Tarek Mohamed Fayez Ahmed , Sameh Ahmed Said Negem , Wesam Ahmed Mohamed Zeyara , Emhemmad Jumha Emhemmad , Abdelkhader Ali Abobaker Omar
In this research, the radiation shielding coefficients for gamma rays were studied resulting from the addition of iron oxide (Fe2O3), antimony oxide (Sb2O3), and bismuth oxide (Bi2O3) to lead sodium aluminum silicate glass using the PHY-X/PSD simulation program at different energies (0.248, 0.347, 0.662, 0.826, 1.17, 1.33, 2.51 MeV) for four experimental compositions according to weight ratios: S1: 60 Pb3O4 − 32 SiO2 − 3 Al2O3 − 5 Na2SO4, S2: 60 Pb3O4 − 29 SiO2 − 3 Fe2O3 − 3 Al2O3 − 5 Na2SO4, S3: 60 Pb3O4 − 29 SiO2 − 3 Sb2O3 − 3 Al2O3 −5 Na2SO4, S4: 60 Pb3O4 − 29 SiO2 − 3 Bi2O3 − 3 Al2O3 − 5 Na2SO4. The results of PHY-X/PSD showed that sample S4 containing bismuth oxide had the best attenuation coefficients at all energies as compared to the other samples, followed by samples S2 and S3 containing iron oxide and antimony oxide, respectively, with approximately the same values of radiation shielding coefficients, and finally sample S1 without additives came. The X-COM results also showed that the photoelectric effect was effective at low energies, represented by the two values 0.248 and 0.347 MeV, while the Compton effect works strongly at medium energies, represented by the values of 0.662, 0.826, and 1.17 MeV, while the effect of pair production begins to appear at approximately 1.33 MeV, and its effect continues to increase as the energy value increases.
{"title":"Effect of replacing SiO2 with Sb2O3, Bi2O3, and Fe2O3 on the radiation shielding properties of lead sodium aluminum silicate glass","authors":"Tarek Mohamed Fayez Ahmed , Sameh Ahmed Said Negem , Wesam Ahmed Mohamed Zeyara , Emhemmad Jumha Emhemmad , Abdelkhader Ali Abobaker Omar","doi":"10.1080/10426507.2025.2524191","DOIUrl":"10.1080/10426507.2025.2524191","url":null,"abstract":"<div><div>In this research, the radiation shielding coefficients for gamma rays were studied resulting from the addition of iron oxide (Fe<sub>2</sub>O<sub>3</sub>), antimony oxide (Sb<sub>2</sub>O<sub>3</sub>), and bismuth oxide (Bi<sub>2</sub>O<sub>3</sub>) to lead sodium aluminum silicate glass using the PHY-X/PSD simulation program at different energies (0.248, 0.347, 0.662, 0.826, 1.17, 1.33, 2.51 MeV) for four experimental compositions according to weight ratios: S1: 60 Pb<sub>3</sub>O<sub>4</sub> − 32 SiO<sub>2</sub> − 3 Al<sub>2</sub>O<sub>3</sub> − 5 Na<sub>2</sub>SO<sub>4</sub>, S2: 60 Pb<sub>3</sub>O<sub>4</sub> − 29 SiO<sub>2</sub> − 3 Fe<sub>2</sub>O<sub>3</sub> − 3 Al<sub>2</sub>O<sub>3</sub> − 5 Na<sub>2</sub>SO<sub>4</sub>, S3: 60 Pb<sub>3</sub>O<sub>4</sub> − 29 SiO<sub>2</sub> − 3 Sb<sub>2</sub>O<sub>3</sub> − 3 Al<sub>2</sub>O<sub>3</sub> −5 Na<sub>2</sub>SO<sub>4</sub>, S4: 60 Pb<sub>3</sub>O<sub>4</sub> − 29 SiO<sub>2</sub> − 3 Bi<sub>2</sub>O<sub>3</sub> − 3 Al<sub>2</sub>O<sub>3</sub> − 5 Na<sub>2</sub>SO<sub>4</sub>. The results of PHY-X/PSD showed that sample S4 containing bismuth oxide had the best attenuation coefficients at all energies as compared to the other samples, followed by samples S2 and S3 containing iron oxide and antimony oxide, respectively, with approximately the same values of radiation shielding coefficients, and finally sample S1 without additives came. The X-COM results also showed that the photoelectric effect was effective at low energies, represented by the two values 0.248 and 0.347 MeV, while the Compton effect works strongly at medium energies, represented by the values of 0.662, 0.826, and 1.17 MeV, while the effect of pair production begins to appear at approximately 1.33 MeV, and its effect continues to increase as the energy value increases.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 7","pages":"Pages 588-595"},"PeriodicalIF":1.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-03DOI: 10.1080/10426507.2025.2515872
Xuan Ke (Data curation Formal analysis Investigation Methodology Validation Visualization Writing – original draft) , Chuangchuang Xu (Data curation Formal analysis Investigation Methodology) , Jiaxi Xu (Conceptualization Data curation Funding acquisition Investigation Methodology Resources Supervision Validation Visualization Writing – original draft Writing – review & editing)
N-Alkyldiazo(nitro)acetanilides generate both isoindigoes and isatins under the catalysis of Cu(MeCN)4PF6 in most cases and show obvious steric effect of both N-alkyl groups and substituents on anilines. Diazo(nitro)acetanilides with less bulky substituents generally favor formation of isoindigoes, while although those with more steric substituents generally disfavor the generation of isoindigoes, the yields of the corresponding isatins do not increase. The copper-catalyzed reaction of N-alkyldiazonitroacetanilides exhibits different chemoselectivity from other diazoacetanilides with α-electron-withdrawing substituents. The reactions were performed under both thermal and photo irradiation conditions, showing similar results.
n -烷基重偶氮（硝基）乙酰苯胺在Cu(MeCN)4PF6的催化作用下多数生成异靛蓝和异靛素，并在苯胺上表现出明显的n -烷基和取代基的立体效应。取代基较少的重氮（硝基）乙酰苯胺通常有利于异靛蓝的生成，而取代基较多的重氮（硝基）乙酰苯胺通常不利于异靛蓝的生成，但相应的异靛蓝的产率不增加。铜催化的n-烷基重氮硝基乙酰苯胺的化学选择性不同于其他具有α-吸电子取代基的重氮乙酰苯胺。在热和光照射条件下进行了反应，得到了相似的结果。
{"title":"Copper-catalyzed synthesis of isoindigoes and isatins from diazo(nitro)acetanilides","authors":"Xuan Ke (Data curation Formal analysis Investigation Methodology Validation Visualization Writing – original draft) , Chuangchuang Xu (Data curation Formal analysis Investigation Methodology) , Jiaxi Xu (Conceptualization Data curation Funding acquisition Investigation Methodology Resources Supervision Validation Visualization Writing – original draft Writing – review & editing)","doi":"10.1080/10426507.2025.2515872","DOIUrl":"10.1080/10426507.2025.2515872","url":null,"abstract":"<div><div><em>N</em>-Alkyldiazo(nitro)acetanilides generate both isoindigoes and isatins under the catalysis of Cu(MeCN)<sub>4</sub>PF<sub>6</sub> in most cases and show obvious steric effect of both <em>N</em>-alkyl groups and substituents on anilines. Diazo(nitro)acetanilides with less bulky substituents generally favor formation of isoindigoes, while although those with more steric substituents generally disfavor the generation of isoindigoes, the yields of the corresponding isatins do not increase. The copper-catalyzed reaction of <em>N</em>-alkyldiazonitroacetanilides exhibits different chemoselectivity from other diazoacetanilides with α-electron-withdrawing substituents. The reactions were performed under both thermal and photo irradiation conditions, showing similar results.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 7","pages":"Pages 539-551"},"PeriodicalIF":1.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-03DOI: 10.1080/10426507.2025.2507021
Manohar D. Suryawanshi (Conceptualization Resources Writing – original draft Writing – review & editing) , Nitin M. Thorat (Methodology) , Vilas A. Sudrik (Investigation) , Ganesh D. Suryawanshi (Conceptualization Methodology) , Pravin C. Mhaske (Project administration Supervision) , Shamrao P. Lawande (Supervision)
Synthesis of multiheterocyclic compounds enhances the bioactivity of core moieties. The number of heteroatoms present in the molecule provides good binding nature as well as lyophilic nature. New and efficient method has been developed for one-pot synthesis of 6-(benzyloxy)-5-(2-(2-((3-aryl-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazinyl)-thiazol-4-yl)quinolin-2(1H)-one derivatives. The reaction between 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehyde and thiosemicarbazide followed by cyclocondensation reaction with 6-benzyloxy-5-(2-bromo-acetyl)-1H-quinolin-2-one in ethanol under microwave or ultra-sonication condition affords the desired compounds. The described method of synthesis is time saving and contains efficient protocols.
{"title":"An efficient one pot synthesis of 6-(benzyloxy)-5-(2-(2-((3-aryl-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazinyl)thiazol-4-yl)quinolin-2(1H)-ones","authors":"Manohar D. Suryawanshi (Conceptualization Resources Writing – original draft Writing – review & editing) , Nitin M. Thorat (Methodology) , Vilas A. Sudrik (Investigation) , Ganesh D. Suryawanshi (Conceptualization Methodology) , Pravin C. Mhaske (Project administration Supervision) , Shamrao P. Lawande (Supervision)","doi":"10.1080/10426507.2025.2507021","DOIUrl":"10.1080/10426507.2025.2507021","url":null,"abstract":"<div><div>Synthesis of multiheterocyclic compounds enhances the bioactivity of core moieties. The number of heteroatoms present in the molecule provides good binding nature as well as lyophilic nature. New and efficient method has been developed for one-pot synthesis of 6-(benzyloxy)-5-(2-(2-((3-aryl-1-phenyl-1<em>H</em>-pyrazol-4-yl)methylene)hydrazinyl)-thiazol-4-yl)quinolin-2(1<em>H</em>)-one derivatives. The reaction between 3-aryl-1-phenyl-1<em>H</em>-pyrazole-4-carbaldehyde and thiosemicarbazide followed by cyclocondensation reaction with 6-benzyloxy-5-(2-bromo-acetyl)-1<em>H</em>-quinolin-2-one in ethanol under microwave or ultra-sonication condition affords the desired compounds. The described method of synthesis is time saving and contains efficient protocols.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 6","pages":"Pages 489-498"},"PeriodicalIF":1.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-03DOI: 10.1080/10426507.2025.2507020
Lu Yin (Conceptualization Data curation Formal analysis Investigation Methodology Resources Software Validation Visualization Writing – original draft) , Shengyang Ding (Supervision) , Tao Zhang (Supervision) , Li Lv (Supervision) , Wenxiang Tang (Supervision) , Yubao Liu (Supervision) , Shengwei Tang (Funding acquisition Project administration Supervision Writing – review & editing)
Phosphate tailings, a solid waste generated during phosphate processing, pose environmental pollution risks. Phosphate concentrate and dicalcium phosphate monohydrate Ca(H2PO4)2 · H2O were successfully prepared from phosphate tailings through a selective leaching of dilute H3PO4 solution followed by evaporation, concentration, and cooling crystallization. The process conditions were optimized using the response surface methodology (RSM). Reaction temperature was identified as the most significant factor during acid leaching. Raising temperatures increased the phosphate grade of the residue. Leaching conditions were optimized as 16 P2O5 wt% H3PO4 concentration, 75 °C, and 30 min. Under these conditions, the P2O5 content of the concentrate reached 27.1%. During crystallization, the seed dosage was the key factor affecting the yield. Increasing the seed dosage significantly improved crystallization yield. Under optimal conditions, the yield of Ca(H2PO4)2 · H2O was 22.7%.
{"title":"Response surface analyzing the leaching process and crystallization process in the preparation of phosphate concentrate and Ca(H2PO4)2 ∙ H2O from phosphate tailing","authors":"Lu Yin (Conceptualization Data curation Formal analysis Investigation Methodology Resources Software Validation Visualization Writing – original draft) , Shengyang Ding (Supervision) , Tao Zhang (Supervision) , Li Lv (Supervision) , Wenxiang Tang (Supervision) , Yubao Liu (Supervision) , Shengwei Tang (Funding acquisition Project administration Supervision Writing – review & editing)","doi":"10.1080/10426507.2025.2507020","DOIUrl":"10.1080/10426507.2025.2507020","url":null,"abstract":"<div><div>Phosphate tailings, a solid waste generated during phosphate processing, pose environmental pollution risks. Phosphate concentrate and dicalcium phosphate monohydrate Ca(H<sub>2</sub>PO<sub>4</sub>)<sub>2</sub> · H<sub>2</sub>O were successfully prepared from phosphate tailings through a selective leaching of dilute H<sub>3</sub>PO<sub>4</sub> solution followed by evaporation, concentration, and cooling crystallization. The process conditions were optimized using the response surface methodology (RSM). Reaction temperature was identified as the most significant factor during acid leaching. Raising temperatures increased the phosphate grade of the residue. Leaching conditions were optimized as 16 P<sub>2</sub>O<sub>5</sub> wt% H<sub>3</sub>PO<sub>4</sub> concentration, 75 °C, and 30 min. Under these conditions, the P<sub>2</sub>O<sub>5</sub> content of the concentrate reached 27.1%. During crystallization, the seed dosage was the key factor affecting the yield. Increasing the seed dosage significantly improved crystallization yield. Under optimal conditions, the yield of Ca(H<sub>2</sub>PO<sub>4</sub>)<sub>2</sub> · H<sub>2</sub>O was 22.7%.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 6","pages":"Pages 515-527"},"PeriodicalIF":1.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-03DOI: 10.1080/10426507.2025.2509703
Emine Kutlu (Conceptualization Investigation Methodology Writing – original draft) , Fatih Mehmet Emen (Conceptualization Data curation Formal analysis Funding acquisition Investigation Methodology Project administration Supervision Writing – original draft Writing – review & editing) , Muhammad Asim Ali (Conceptualization Formal analysis Investigation Methodology) , Ali Ihsan Karacolak (Conceptualization Formal analysis Investigation Methodology) , Tuncay Yesilkaynak (Conceptualization Formal analysis Investigation Methodology Writing – original draft) , Kübra Yıldırım (Conceptualization Formal analysis Investigation Methodology) , Cemilenur Ataş (Conceptualization Formal analysis Investigation Methodology) , Ece Şimşek (Conceptualization Formal analysis Investigation Methodology) , Ahmet Yılmaz Çoban (Conceptualization Formal analysis Investigation Methodology Writing – original draft Writing – review & editing)
In this study, N-([1,1′-biphenyl]-2-ylcarbamothioyl)-2-chlorobenzamide (L1), N-([1,1′-biphenyl]-2-ylcarbamothioyl)furan-2-carboxamide (L2), N-((5-chloropyridin-2-yl)carbamothioyl)thiophene-2-carboxamide (L3) were synthesized and their structural characterizations were performed with FT-IR,1H-NMR and 13C-NMR techniques. The crystal structure analysis of L3 was performed by single crystal X-ray diffraction method. Hirshfeld surface analyses and HOMO–LUMO energy level analyses were carried out for the L1 and L3. The HOMO energies were calculated to be −0.21010 and −0.25281 eV, and the LUMO energies were −0.07204 and −0.17947 eV. Ionization and electron affinity values were also calculated. Newly synthesized thiourea derivatives were evaluated by nitrate reduction assay for anti-tuberculosis activity against 5 ATCC reference strains and 3 isolates of Mycobacterium tuberculosis with different resistance profiles. Among the synthesized derivatives, L3 did not show any anti-TB activity, while L1 showed only low activity against ATCC 35837. Only the L2 compound showed potent anti-TB activity against all M. tuberculosis strains tested. The L2 compound has the potential to be a promising active agent against drug-resistant M. tuberculosis.
{"title":"Novel aroylthioureas against Mycobacterium tuberculosis","authors":"Emine Kutlu (Conceptualization Investigation Methodology Writing – original draft) , Fatih Mehmet Emen (Conceptualization Data curation Formal analysis Funding acquisition Investigation Methodology Project administration Supervision Writing – original draft Writing – review & editing) , Muhammad Asim Ali (Conceptualization Formal analysis Investigation Methodology) , Ali Ihsan Karacolak (Conceptualization Formal analysis Investigation Methodology) , Tuncay Yesilkaynak (Conceptualization Formal analysis Investigation Methodology Writing – original draft) , Kübra Yıldırım (Conceptualization Formal analysis Investigation Methodology) , Cemilenur Ataş (Conceptualization Formal analysis Investigation Methodology) , Ece Şimşek (Conceptualization Formal analysis Investigation Methodology) , Ahmet Yılmaz Çoban (Conceptualization Formal analysis Investigation Methodology Writing – original draft Writing – review & editing)","doi":"10.1080/10426507.2025.2509703","DOIUrl":"10.1080/10426507.2025.2509703","url":null,"abstract":"<div><div>In this study, <em>N</em>-([1,1′-biphenyl]-2-ylcarbamothioyl)-2-chlorobenzamide (L<sup>1</sup>), <em>N</em>-([1,1′-biphenyl]-2-ylcarbamothioyl)furan-2-carboxamide (L<sup>2</sup>), <em>N</em>-((5-chloropyridin-2-yl)carbamothioyl)thiophene-2-carboxamide (L<sup>3</sup>) were synthesized and their structural characterizations were performed with FT-IR,<sup>1</sup>H-NMR and <sup>13</sup>C-NMR techniques. The crystal structure analysis of L<sup>3</sup> was performed by single crystal X-ray diffraction method. Hirshfeld surface analyses and HOMO–LUMO energy level analyses were carried out for the L<sup>1</sup> and L<sup>3</sup>. The HOMO energies were calculated to be −0.21010 and −0.25281 eV, and the LUMO energies were −0.07204 and −0.17947 eV. Ionization and electron affinity values were also calculated. Newly synthesized thiourea derivatives were evaluated by nitrate reduction assay for anti-tuberculosis activity against 5 ATCC reference strains and 3 isolates of <em>Mycobacterium tuberculosis</em> with different resistance profiles. Among the synthesized derivatives, L<sup>3</sup> did not show any anti-TB activity, while L<sup>1</sup> showed only low activity against ATCC 35837. Only the L<sup>2</sup> compound showed potent anti-TB activity against all <em>M. tuberculosis strains</em> tested. The L<sup>2</sup> compound has the potential to be a promising active agent against drug-resistant <em>M. tuberculosis</em>.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 6","pages":"Pages 528-537"},"PeriodicalIF":1.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-03DOI: 10.1080/10426507.2025.2508322
Abdüllatif Karakaya (Methodology Resources Writing – original draft) , Betül Kaya (Methodology Writing – original draft Writing – review & editing) , Mehmet Taha Yıldız (Methodology Writing – original draft Writing – review & editing) , Tuğba Erçetin (Methodology Writing – original draft) , Ulviye Acar Çevik (Methodology Writing – original draft Writing – review & editing Supervision)
This study aimed to synthesize 11 new potential anti-Alzheimer agents via cholinesterase inhibition and antioxidant activity. In order to obtain new thiazole derivatives, first the reaction of thiosemicarbazide with 5-methyl-thiophene-2-carbaldehyde was performed, then the cyclization of the obtained compounds with 2-bromoacetophenone derivatives was performed and the target compounds (2a–2k) were obtained. The acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzyme inhibitory effects and antioxidant properties of newly synthesized thiazole derivatives were evaluated. According to cholinesterase inhibition assay, all synthesized compounds were weak inhibitors of AChE and BuChE. Generally, compounds were more effective against AChE than BuChE. Among the compounds, compound 2e has the highest AChE inhibition with a percentage inhibition value of 27.73 ± 0.008 μM. According to DPPH radical scavenging activity assay, compounds 2d and 2 g were most potent antioxidant agents with IC50 values of 29.12 ± 0.008 μM and 25.14 ± 0.003 μM, while that of gallic acid was found 29.48 ± 0.014 µM.
{"title":"Design, synthesis and evaluation of thiazole derivatives as cholinesterase inhibitors and antioxidant agents","authors":"Abdüllatif Karakaya (Methodology Resources Writing – original draft) , Betül Kaya (Methodology Writing – original draft Writing – review & editing) , Mehmet Taha Yıldız (Methodology Writing – original draft Writing – review & editing) , Tuğba Erçetin (Methodology Writing – original draft) , Ulviye Acar Çevik (Methodology Writing – original draft Writing – review & editing Supervision)","doi":"10.1080/10426507.2025.2508322","DOIUrl":"10.1080/10426507.2025.2508322","url":null,"abstract":"<div><div>This study aimed to synthesize 11 new potential anti-Alzheimer agents <em>via</em> cholinesterase inhibition and antioxidant activity. In order to obtain new thiazole derivatives, first the reaction of thiosemicarbazide with 5-methyl-thiophene-2-carbaldehyde was performed, then the cyclization of the obtained compounds with 2-bromoacetophenone derivatives was performed and the target compounds <strong>(2a–2k)</strong> were obtained. The acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzyme inhibitory effects and antioxidant properties of newly synthesized thiazole derivatives were evaluated. According to cholinesterase inhibition assay, all synthesized compounds were weak inhibitors of AChE and BuChE. Generally, compounds were more effective against AChE than BuChE. Among the compounds, compound <strong>2e</strong> has the highest AChE inhibition with a percentage inhibition value of 27.73 ± 0.008 μM. According to DPPH radical scavenging activity assay, compounds <strong>2d</strong> and <strong>2 g</strong> were most potent antioxidant agents with IC<sub>50</sub> values of 29.12 ± 0.008 μM and 25.14 ± 0.003 μM, while that of gallic acid was found 29.48 ± 0.014 µM.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 6","pages":"Pages 499-508"},"PeriodicalIF":1.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-03DOI: 10.1080/10426507.2025.2509727
Anchal Dabas (Investigation Methodology Writing – original draft) , Ram Singh (Conceptualization Supervision Writing – review & editing)
Eco-friendly strategies prioritize the use of renewable resources for organic synthesis. The developed method is a facile, sustainable, and efficient procedure to synthesize 2-amino-1,3-thiazole derivatives in the presence of aqueous waste leaves extract of Neem (Azadirachta indica) plant. The products were obtained in 45 min at room temperature in 90–96% yields without additional purification. The acidic nature of the aqueous extract polarizes the thiourea and carbonyl carbon. The established protocol includes principles of green chemistry.
{"title":"A facile and sustainable synthesis of 2-amino-1,3-thiazole derivatives using aqueous extract of waste neem leaves","authors":"Anchal Dabas (Investigation Methodology Writing – original draft) , Ram Singh (Conceptualization Supervision Writing – review & editing)","doi":"10.1080/10426507.2025.2509727","DOIUrl":"10.1080/10426507.2025.2509727","url":null,"abstract":"<div><div>Eco-friendly strategies prioritize the use of renewable resources for organic synthesis. The developed method is a facile, sustainable, and efficient procedure to synthesize 2-amino-1,3-thiazole derivatives in the presence of aqueous waste leaves extract of Neem (<em>Azadirachta indica</em>) plant. The products were obtained in 45 min at room temperature in 90–96% yields without additional purification. The acidic nature of the aqueous extract polarizes the thiourea and carbonyl carbon. The established protocol includes principles of green chemistry.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 6","pages":"Pages 509-514"},"PeriodicalIF":1.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The electrolytic oxidation of H2S is a promising energy conversion technology for hydrogen production and the removal of this environmental pollutant. Additionally, the anode oxidation reactions offer the added advantage of obtaining valuable chemicals. Here, a series of alkaline ionic liquids ([DBNH]IM, [DBUH]IM, [DBNH][1,2,4-triaz], [NH4Cl][MEA], and [ChCl][MEA]) aqueous solutions were used as absorbents and anolytes for absorption-electrolysis cycles with pristine carbon cloth to enhance H2S absorption and electrolysis, coupling with efficient HER. [DBNH]IM-based electrolyte exhibited higher H2S trapping capacity primarily due to its ability in H2S absorption and modulation effect. Under constant potential electrolysis at 1.2 V vs RHE applied for 12 h, the maximum hydrogen production rate reached 1150 μmol h−1. Even after three cycles, the hydrogen production rate in [DBNH]IM-based system remained at approximately 185 μmol h−1. The anodic sulfur product can be separated from the electrolyte by bubbling CO2; solid product was confirmed to be α-sulfur as high as 99.207%. In summary, the obtained electrolyte demonstrates effective decomposition of H2S while simultaneously producing clean hydrogen and sulfur in a sustainable way.
电解氧化H2S是一种很有前途的制氢和脱除环境污染物的能量转换技术。此外，阳极氧化反应提供了获得有价值的化学物质的额外优势。本研究采用碱性离子液体（[DBNH]IM、[DBUH]IM、[DBNH][1,2,4-三az]、[NH4Cl][MEA]和[ChCl][MEA]）水溶液作为吸附剂和电解质，与原始碳布进行吸附-电解循环，以增强H2S的吸收和电解，并结合高效HER。[DBNH] im基电解质具有较高的H2S捕获能力，主要是由于其对H2S的吸收和调制作用。在1.2 V vs RHE等电位条件下电解12 h，产氢率最高可达1150 μmol h−1。经过3次循环后，[DBNH] im体系的产氢速率仍保持在185 μmol h−1左右。通过鼓泡CO2可以将阳极硫产物从电解质中分离出来；固体产物α-硫含量高达99.207%。综上所述，所获得的电解质能够有效分解H2S，同时以可持续的方式产生清洁的氢和硫。
{"title":"An integrated absorption and electrolysis process to H2S treatment using alkaline ionic liquids aqueous solution","authors":"Qianqian Peng (Investigation Methodology Writing – original draft) , Longmei Shi (Investigation Methodology Writing – review & editing) , Chengxuan Zhou (Investigation Methodology Writing – review & editing) , Anshuang Wu (Investigation) , Shengyun Xu (Investigation) , Shucan Qin (Writing – review & editing) , Weizhen Kong (Investigation) , Lihua Zang (Formal analysis) , Yunqian Ma (Conceptualization Data curation Funding acquisition Supervision Writing – review & editing)","doi":"10.1080/10426507.2025.2498438","DOIUrl":"10.1080/10426507.2025.2498438","url":null,"abstract":"<div><div>The electrolytic oxidation of H<sub>2</sub>S is a promising energy conversion technology for hydrogen production and the removal of this environmental pollutant. Additionally, the anode oxidation reactions offer the added advantage of obtaining valuable chemicals. Here, a series of alkaline ionic liquids ([DBNH]IM, [DBUH]IM, [DBNH][1,2,4-triaz], [NH<sub>4</sub>Cl][MEA], and [ChCl][MEA]) aqueous solutions were used as absorbents and anolytes for absorption-electrolysis cycles with pristine carbon cloth to enhance H<sub>2</sub>S absorption and electrolysis, coupling with efficient HER. [DBNH]IM-based electrolyte exhibited higher H<sub>2</sub>S trapping capacity primarily due to its ability in H<sub>2</sub>S absorption and modulation effect. Under constant potential electrolysis at 1.2 V vs RHE applied for 12 h, the maximum hydrogen production rate reached 1150 μmol h<sup>−1</sup>. Even after three cycles, the hydrogen production rate in [DBNH]IM-based system remained at approximately 185 μmol h<sup>−1</sup>. The anodic sulfur product can be separated from the electrolyte by bubbling CO<sub>2</sub>; solid product was confirmed to be α-sulfur as high as 99.207%. In summary, the obtained electrolyte demonstrates effective decomposition of H<sub>2</sub>S while simultaneously producing clean hydrogen and sulfur in a sustainable way.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 5","pages":"Pages 450-459"},"PeriodicalIF":1.4,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The reactivity of phosphorus pentasulfide (P2S5) in the presence of a series of phosphoryl chloride derivatives has been investigated using the M06-2X and B3LYP functionals in conjunction with the 6-311 + G(d,p) basis set. Our computations indicate that both the regioselectivity of P2S5 and the physical nature of the interaction in P2S5 complexes can be rationalized using conceptual DFT reactivity indices, natural bond orbitals (NBO) and symmetry-adapted perturbation theory (SAPT2 + dMP2). The molecular electrostatic potential (MEP) of P2S5 exhibits σ- and π-hole regions around the P = S bond: one hole is carried by the S atom and located along the P-S bond, while two others are found at both sides of the P atom. Unlike the P4S10 dimer whose reaction is obstructed by a huge activation energy, its monomeric form (P2S5) successfully yields a product following a reaction path with a low activation energy and involving metastable complex intermediates. The adducts formed along the P = S unit are less stable than those attacking the P = S bond perpendicularly. The process involves the concomitant weakening of the P···S bond of P2S5 and reinforcement of the P=O bond, turning P2S5 into P2S4O.
{"title":"Understanding the reactivity of phosphorus pentasulfide with a series of phosphoryl chloride derivatives: Interplay between σ-hole, π-hole and H-bonding interactions","authors":"Pierre Osomba Lohohola , Bienfait Kabuyaya Isamura , Thierry Mawete Dani , Blaise Mbala Mavinga , Jules Tshishimbi Muya","doi":"10.1080/10426507.2025.2496517","DOIUrl":"10.1080/10426507.2025.2496517","url":null,"abstract":"<div><div>The reactivity of phosphorus pentasulfide (P<sub>2</sub>S<sub>5</sub>) in the presence of a series of phosphoryl chloride derivatives has been investigated using the M06-2X and B3LYP functionals in conjunction with the 6-311 + G(d,p) basis set. Our computations indicate that both the regioselectivity of P<sub>2</sub>S<sub>5</sub> and the physical nature of the interaction in P<sub>2</sub>S<sub>5</sub> complexes can be rationalized using conceptual DFT reactivity indices, natural bond orbitals (NBO) and symmetry-adapted perturbation theory (SAPT2 + dMP2). The molecular electrostatic potential (MEP) of P<sub>2</sub>S<sub>5</sub> exhibits σ- and π-hole regions around the P = S bond: one hole is carried by the S atom and located along the P-S bond, while two others are found at both sides of the P atom. Unlike the P<sub>4</sub>S<sub>10</sub> dimer whose reaction is obstructed by a huge activation energy, its monomeric form (P<sub>2</sub>S<sub>5</sub>) successfully yields a product following a reaction path with a low activation energy and involving metastable complex intermediates. The adducts formed along the P = S unit are less stable than those attacking the P = S bond perpendicularly. The process involves the concomitant weakening of the P···S bond of P<sub>2</sub>S<sub>5</sub> and reinforcement of the P=O bond, turning P<sub>2</sub>S<sub>5</sub> into P<sub>2</sub>S<sub>4</sub>O.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 5","pages":"Pages 460-469"},"PeriodicalIF":1.4,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-04DOI: 10.1080/10426507.2025.2498441
Zelong Liu , Peihang Shen , Chunlai Liu , Na Wang , Jianglei Hu , Yibo Zhang
In this work, Ti-Mesoporous silica (Ti@SBA15)-supported phosphomolybdic acid (HPMo) composites, HPMo/Ti@SBA15, were synthesized by a one-pot hydrothermal method. The physical and chemical properties of the composites were characterized by XRD, N2 adsorption-desorption, FT-IR spectroscopy, TEM, SEM, and XPS. The results showed that the pores and surface of SBA-15 were loaded with HPMo and Ti(IV), and the dual active sites were well dispersed without agglomeration. The HPMo/Ti@SBA15 composite exhibited better performance than the single active site catalysts, HPMo@SBA15 and TiO2@SBA15, with high catalytic activity and stable reusability during oxidative desulfurization. The dispersion of the dual active components within the SBA-15 cages and synergistic catalytic effects between the two gave the composites catalytic activity and stability in the desulfurization experiments with different sulfur-containing substrates.
{"title":"Dual-active-site composite of Ti-mesoporous silica-supported phosphomolybdic acid as an oxidative desulfurization catalyst","authors":"Zelong Liu , Peihang Shen , Chunlai Liu , Na Wang , Jianglei Hu , Yibo Zhang","doi":"10.1080/10426507.2025.2498441","DOIUrl":"10.1080/10426507.2025.2498441","url":null,"abstract":"<div><div>In this work, Ti-Mesoporous silica (Ti@SBA15)-supported phosphomolybdic acid (HPMo) composites, HPMo/Ti@SBA15, were synthesized by a one-pot hydrothermal method. The physical and chemical properties of the composites were characterized by XRD, N<sub>2</sub> adsorption-desorption, FT-IR spectroscopy, TEM, SEM, and XPS. The results showed that the pores and surface of SBA-15 were loaded with HPMo and Ti(IV), and the dual active sites were well dispersed without agglomeration. The HPMo/Ti@SBA15 composite exhibited better performance than the single active site catalysts, HPMo@SBA15 and TiO<sub>2</sub>@SBA15, with high catalytic activity and stable reusability during oxidative desulfurization. The dispersion of the dual active components within the SBA-15 cages and synergistic catalytic effects between the two gave the composites catalytic activity and stability in the desulfurization experiments with different sulfur-containing substrates.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 5","pages":"Pages 470-478"},"PeriodicalIF":1.4,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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