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Characterizing the nonmonotonic behavior of mutual information along biochemical reaction cascades 表征生化反应级联中互信息的非单调行为
IF 2.4 3区 物理与天体物理 Q1 Mathematics Pub Date : 2024-09-10 DOI: 10.1103/physreve.110.034309
Raymond Fan, Andreas Hilfinger
Cells sense environmental signals and transmit information intracellularly through changes in the abundance of molecular components. Such molecular abundances can be measured in single cells and exhibit significant heterogeneity in clonal populations even in identical environments. Experimentally observed joint probability distributions can then be used to quantify the covariability and mutual information between molecular abundances along signaling cascades. However, because stationary state abundances along stochastic biochemical reaction cascades are not conditionally independent, their mutual information is not constrained by the data-processing inequality. Here, we report the conditions under which the mutual information between stationary state abundances increases along a cascade of biochemical reactions. This nonmonotonic behavior can be intuitively understood in terms of noise propagation and time-averaging stochastic fluctuations that are short-lived compared to an extrinsic signal. Our results reemphasize that mutual information measurements of stationary state distributions of cellular components may be of limited utility for characterizing cellular signaling processes because they do not measure information transfer.
细胞通过分子成分丰度的变化来感知环境信号并在细胞内传递信息。这种分子丰度可以在单细胞中测量,即使在相同的环境中,在克隆群体中也会表现出显著的异质性。实验观察到的联合概率分布可用于量化信号级联分子丰度之间的共变性和互信息。然而,由于随机生化反应级联的静止态丰度不是条件独立的,它们的互信息不受数据处理不等式的限制。在这里,我们报告了在什么条件下,生化反应级联上的静止态丰度之间的互信息会增加。这种非单调行为可以直观地从噪声传播和时间平均随机波动的角度来理解,与外在信号相比,随机波动的持续时间很短。我们的研究结果再次强调,细胞成分静止状态分布的互信息测量对于描述细胞信号传导过程可能作用有限,因为它们不能测量信息传递。
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引用次数: 0
Nonsymmetrical thermal conductivity along the director field in ferroelectric nematic liquid crystals 铁电向列液晶中沿导演场的非对称热导率
IF 2.4 3区 物理与天体物理 Q1 Mathematics Pub Date : 2024-09-09 DOI: 10.1103/physreve.110.034703
Lidiane Maria de Souza, Junaid Sofi, Erms Pereira
The synthesis of ferroelectric nematic liquid crystals (FNLCs) concludes the long wait for their existence and potential usage in multiple liquid crystal based applications. In FNLCs, electric polarization in the nematic phase significantly decreases the switching time of in-on display pixels. In this article, we report the occurrence of translation symmetry breaking for heat propagation along the director field n̂ in the ferroelectric nematic phase. Due to the CV symmetry of such a phase and close similarity to the bent-core polar liquid crystal phase, a rank-3 tensor describes its scalar order parameter and algebraic deductions. The finite element simulations show the occurrence of the nonsymmetrical thermal conductivity along n̂. The preferential heat transport in FNLCs can allow them to work as an all-thermal monophase non-nanostructured single-material thermal rectifier. We expect that this study will contribute towards the FNLCs application as functional layers and inks.
铁电向列型液晶(FNLC)的合成结束了人们对其存在的漫长等待,以及其在多种液晶应用中的潜在用途。在 FNLC 中,向列相中的电极化可显著缩短导通显示像素的开关时间。在本文中,我们报告了铁电向列相中热量沿导演场 n ̂ 传播时发生平移对称性破坏的情况。由于这种相具有 C∞V 对称性,且与弯芯极性液晶相十分相似,因此用等级-3 张量来描述其标量阶参数和代数推导。有限元模拟显示了沿 n ̂方向的非对称热导率。FNLC 中的优先热传输可使其成为全热单相非纳米结构单一材料热整流器。我们希望这项研究能为 FNLCs 作为功能层和油墨的应用做出贡献。
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引用次数: 0
Infection fronts in randomly varying transmission-rate media 随机变化传输速率介质中的感染前沿
IF 2.4 3区 物理与天体物理 Q1 Mathematics Pub Date : 2024-09-09 DOI: 10.1103/physreve.110.034308
Renzo Zagarra, Karina Laneri, Alejandro B. Kolton
We numerically investigate the geometry and transport properties of infection fronts within the spatial SIR model in two dimensions. The model incorporates short-range correlated quenched random transmission rates. Our findings reveal that the critical average transmission rate for the steady-state propagation of the infection is overestimated by the naive mean-field homogenization. Furthermore, we observe that the velocity, profile, and harmfulness of the fronts, given a specific average transmission, are sensitive to the details of randomness. In particular, we find that the harmfulness of the front is larger the more uniform the transmission rate is, suggesting potential optimization in vaccination strategies under constraints like fixed average-transmission rates or limited vaccine resources. The large-scale geometry of the advancing fronts presents nevertheless robust universal features and, for a statistically isotropic and short-range correlated disorder, we get a roughness exponent α0.42±0.10 and a dynamical exponent z1.6±0.10, which are roughly compatible with the one-dimensional Kardar-Parisi-Zhang (KPZ) universality class. We find that the KPZ term and the disorder-induced effective noise are present and have a kinematic origin.
我们在二维空间 SIR 模型中对感染前沿的几何形状和传输特性进行了数值研究。该模型包含短程相关淬火随机传播率。我们的研究结果表明,感染稳态传播的临界平均传播率被天真的平均场均质化所高估。此外,我们还发现,在特定的平均传播率下,前沿的速度、轮廓和有害程度对随机性的细节非常敏感。特别是,我们发现传播率越均匀,前沿的危害性就越大,这表明在固定的平均传播率或有限的疫苗资源等约束条件下,疫苗接种策略有可能得到优化。对于统计上各向同性和短程相关的无序状态,我们得到了粗糙度指数α≈0.42±0.10和动态指数z≈1.6±0.10,这与一维卡达尔-帕里什-张(KPZ)普遍性类基本一致。我们发现 KPZ 项和无序诱导的有效噪声是存在的,并且具有运动学起源。
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引用次数: 0
Reservoir computing with logistic map 利用逻辑地图进行水库计算
IF 2.4 3区 物理与天体物理 Q1 Mathematics Pub Date : 2024-09-09 DOI: 10.1103/physreve.110.034204
R. Arun, M. Sathish Aravindh, A. Venkatesan, M. Lakshmanan
Recent studies on reservoir computing essentially involve a high-dimensional dynamical system as the reservoir, which transforms and stores the input as a higher-dimensional state for temporal and nontemporal data processing. We demonstrate here a method to predict temporal and nontemporal tasks by constructing virtual nodes as constituting a reservoir in reservoir computing using a nonlinear map, namely, the logistic map, and a simple finite trigonometric series. We predict three nonlinear systems, namely, Lorenz, Rössler, and Hindmarsh-Rose, for temporal tasks and a seventh-order polynomial for nontemporal tasks with great accuracy. Also, the prediction is made in the presence of noise and found to closely agree with the target. Remarkably, the logistic map performs well and predicts close to the actual or target values. The low values of the root mean square error confirm the accuracy of this method in terms of efficiency. Our approach removes the necessity of continuous dynamical systems for constructing the reservoir in reservoir computing. Moreover, the accurate prediction for the three different nonlinear systems suggests that this method can be considered a general one and can be applied to predict many systems. Finally, we show that the method also accurately anticipates the time series of the all the three variable of Rössler system for the future (self-prediction).
最近关于蓄水池计算的研究主要涉及一个高维动态系统作为蓄水池,它将输入转换并存储为更高维的状态,用于时态和非时态数据处理。我们在此展示了一种预测时空任务的方法,即利用非线性映射(即逻辑映射)和简单的有限三角级数,通过构建虚拟节点来构成水库计算中的水库。我们为时间任务预测了三个非线性系统,即洛伦兹系统、罗斯勒系统和辛德马什-罗斯系统,并为非时间任务预测了一个七阶多项式,预测结果非常准确。此外,在有噪声的情况下也能进行预测,并发现预测结果与目标非常吻合。值得注意的是,逻辑图表现出色,预测值接近实际值或目标值。较低的均方根误差值证实了这种方法在效率方面的准确性。我们的方法消除了储层计算中构建储层的连续动力系统的必要性。此外,对三种不同非线性系统的精确预测表明,这种方法可被视为一种通用方法,可用于预测许多系统。最后,我们证明了该方法还能准确预测罗斯勒系统所有三个变量的未来时间序列(自我预测)。
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引用次数: 0
Effective phase diffusion for spin phase evolution under random nonlinear magnetic field 随机非线性磁场下自旋相演化的有效相扩散
IF 2.4 3区 物理与天体物理 Q1 Mathematics Pub Date : 2024-09-09 DOI: 10.1103/physreve.110.034119
Guoxing Lin
The general theoretical description of spin self-diffusion under a nonlinear gradient magnetic field is proposed, which extends the effective phase diffusion method for a linear gradient field. Based on the phase diffusion, the proposed method reveals the general features of phase evolutions in nonlinear gradient fields. There are three types of phase evolutions: phase diffusion, float phase evolution, and shift evolution based on the starting position. For spin diffusion near the origin of the nonlinear field, these three phase evolutions significantly affect the nuclear magnetic resonance (NMR) signal. The traditional methods have difficulties in handling these three-phase evolutions. Notably, the phase from float phase evolution is missed or misplaced in traditional methods, which leads to incorrect NMR signal attenuation or phase shift. The method here shows that the diffusing and float phase evolutions come from the first and second derivatives of the gradient field. Based on these three phase evolutions, the phase variance and corresponding NMR signal attenuation are obtained, as demonstrated by calculating the phase diffusions under both parabolic and cubic fields. The results indicate that signal attenuation obeys Gaussian attenuation for a short time, then changes to follow Lorentzian or Mittag-Leffler function attenuations as time increases, significantly different from Gaussian attenuation. For spins starting diffusion far away from the origin of the field gradient, the signal attenuation is Gaussian, but the float phase still has an important effect on the total phase shift of even-order gradient fields, which could be used to measure the diffusion coefficient directly. Random walk simulations were performed, which support the obtained theoretical results. General theoretical expressions are obtained, which can handle random order nonlinear gradient fields. The results could help develop advanced experimental techniques based on a nonlinear gradient field in NMR and magnetic resonance imaging.
提出了非线性梯度磁场下自旋自扩散的一般理论描述,扩展了线性梯度磁场的有效相扩散方法。基于相扩散,提出的方法揭示了非线性梯度磁场中相演化的一般特征。相位演化有三种类型:相位扩散、浮动相位演化和基于起始位置的位移演化。对于非线性场原点附近的自旋扩散,这三种相位演化会显著影响核磁共振(NMR)信号。传统方法很难处理这些三相演变。值得注意的是,在传统方法中,浮动相演变的相位会被遗漏或错位,从而导致不正确的核磁共振信号衰减或相移。本文的方法表明,扩散和浮动相位演化来自梯度场的一阶和二阶导数。根据这三种相位演化,可以得到相位方差和相应的 NMR 信号衰减,这一点通过计算抛物线场和立方场下的相位扩散得到了证明。结果表明,信号衰减在短时间内遵从高斯衰减,然后随着时间的增加而改变为遵从洛伦兹函数或米塔格-勒弗勒函数衰减,这与高斯衰减有很大不同。对于远离场梯度原点开始扩散的自旋来说,信号衰减是高斯衰减,但浮动相位对偶阶梯度场的总相移仍有重要影响,可用于直接测量扩散系数。我们进行了随机漫步模拟,这支持了所获得的理论结果。得到的一般理论表达式可以处理随机阶非线性梯度场。这些结果有助于在核磁共振和磁共振成像中开发基于非线性梯度场的先进实验技术。
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引用次数: 0
Ballistic to diffusive transition for swimmers in a periodic vortex array 周期性旋涡阵列中游泳者从弹道到扩散的转变
IF 2.4 3区 物理与天体物理 Q1 Mathematics Pub Date : 2024-09-09 DOI: 10.1103/physreve.110.034203
Taylor J. Whitney, Kevin A. Mitchell
We study the transport of rigid ellipsoidal swimmers in a periodic vortex array via numerical simulation and dynamical systems analysis. Via ensemble simulations, we show the counterintuitive result that slower swimming speeds can generate fast ballistic transport, while faster swimming speeds generate chaotic and diffusive transport, which is inherently slower in the long run. To explain this, we use the symmetry of the flow to construct a time-reversible Poincaré return map on a two-dimensional surface of section in phase space. For sufficiently small swimming speeds, we find stable periodic orbits on the surface of section surrounded by invariant tori, similar to Kolmogorov-Arnold-Moser curves. Trajectories within these tori are ballistic. As the swimming speed is increased, the periodic orbits undergo a sequence of period-doubling bifurcations that destroys the ballistic tori. These bifurcations exactly match the ballistic to diffusive transition from the ensemble simulations. Additional ensemble simulations are used to test the robustness of these results to noise. The ballistic behavior is destroyed as the strength of rotational diffusion increases. However, we estimate that the ballistic tori might still be seen in experiments.
我们通过数值模拟和动力系统分析,研究了刚性椭球形游泳体在周期性涡流阵列中的传输问题。通过集合模拟,我们展示了一个与直觉相反的结果:较慢的游动速度可以产生快速的弹道传输,而较快的游动速度则会产生混沌和扩散传输,从长远来看,这种传输本质上是较慢的。为了解释这一现象,我们利用水流的对称性,在相空间的二维截面表面上构建了一个时间可逆的波恩卡莱回归图。在游泳速度足够小的情况下,我们在截面表面上发现了稳定的周期轨道,其周围环绕着与科尔莫戈罗夫-阿诺德-莫泽曲线类似的不变环。这些环内的轨迹是弹道轨迹。随着游泳速度的增加,周期轨道会发生一系列周期加倍的分岔,从而破坏弹道环。这些分岔与集合模拟中从弹道到扩散的转变完全吻合。我们还使用了额外的集合模拟来测试这些结果对噪声的稳健性。随着旋转扩散强度的增加,弹道行为被破坏。不过,我们估计在实验中仍可能看到弹道环。
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引用次数: 0
Observation of Le Sage gravity analog in complex plasma 在复杂等离子体中观测勒萨奇引力模拟物
IF 2.4 3区 物理与天体物理 Q1 Mathematics Pub Date : 2024-09-09 DOI: 10.1103/physreve.110.035203
Andrey V. Zobnin, Andrey M. Lipaev, Roman A. Syrovatka, Alexandr D. Usachev, Vadim N. Naumkin, Oleg F. Petrov, Markus H. Thoma, Oleg V. Novitsky, Sergey N. Ryzhikov
Fragmentation of a suspension of micron-sized plastic microparticles and their contraction into dense globules was experimentally obtained in a gas discharge plasma, when the plasma density was deliberately and abruptly increased. The globules took up spherical shapes 0.14–1.1 mm in diameters and contained from tens to thousands microparticles. The fragmentation and globule formation appears to be similar to the development of gravitational instability. This process is attributed to the Le Sage's like attraction among microparticles in a dense plasma due to the plasma losses inside a globule hypothesized theoretically in the middle of the 1990s. The key role of plasma flows in the attraction was prominently demonstrated in the same experiment by the distinctly visible disintegration of the globules when we reduced the density of the surrounding plasma to the initial one. Also molecular dynamics simulations of fragmentation of microparticle clouds and globules formation qualitatively resemble typical patterns of the fragmentation and collapse of interstellar nebulae.
在气体放电等离子体中,当等离子体密度被有意地突然增加时,微米级塑料微粒悬浮液碎裂并收缩成致密的球状。球体呈球形,直径为 0.14-1.1 毫米,包含数以万计的微颗粒。碎裂和球状物的形成似乎与引力不稳定性的发展相似。这一过程归因于 20 世纪 90 年代中期理论上假设的球体内等离子体损耗导致的稠密等离子体中微粒子之间类似勒萨奇的吸引力。在同一实验中,当我们将周围等离子体的密度降低到初始密度时,球状微粒会发生明显可见的解体,这充分证明了等离子体流在吸引力中的关键作用。此外,微粒子云的碎裂和球状物形成的分子动力学模拟与星际星云碎裂和坍缩的典型模式非常相似。
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引用次数: 0
Statistical physical view of statistical inference in Bayesian linear regression model 贝叶斯线性回归模型中统计推断的统计物理视角
IF 2.4 3区 物理与天体物理 Q1 Mathematics Pub Date : 2024-09-09 DOI: 10.1103/physreve.110.034118
Kazuaki Murayama
This paper considers similarities between statistical physics and Bayes inference through the Bayesian linear regression model. Some similarities have been discussed previously, such as the analogy between the marginal likelihood in Bayes inference and the partition function in statistical mechanics. In particular, this paper considers the proposal to associate discrete sample size with inverse temperature [C. H. LaMont and P. A. Wiggins, Phys. Rev. E 99, 052140 (2019)]. The previous study suggested that incorporating this similarity motivates the derivation of analogs of thermodynamic functions such as energy and entropy. The study also anticipated that those analogous functions have potential to describe Bayes estimation from physical points of view and to provide physical insights into mechanisms of estimation. This paper incorporates a macroscopic perspective as an asymptotics similar to the thermodynamic limit into the previous suggestion. Its motivation stems from the statistical mechanical concept of deriving thermodynamic functions that characterize macroscopic properties of macroscopic systems. This incorporation not only allows analogs of macroscopic thermodynamic functions to be considered but also suggests a candidate for an analog of inverse temperature with continuity, which is partly consistent with the previous proposal to associate the discrete sample size with inverse temperature. On the basis of this suggestion, we analyze analogs of macroscopic thermodynamic functions for a Bayesian linear regression model which is the basis of various machine learning models. We further investigate, through the behavior of these functions, how Bayes estimation is described from the perspective of physics and what kind of physical insight is obtained. As a result, the estimation of regression coefficients, which is the primary task of regression, appears to be described by the physical picture of balance between decreasing energy and increasing entropy as in equilibrium states of thermodynamic systems. More specifically we observe the physical view of Bayes inference as follows: the estimation succeeds where the effect of decreasing energy is dominant at low temperature. On the other hand, the estimation fails where the effect of increasing entropy is dominant at high temperature.
本文通过贝叶斯线性回归模型,探讨了统计物理学与贝叶斯推理之间的相似之处。有些相似之处之前已经讨论过,如贝叶斯推理中的边际似然与统计力学中的分区函数之间的类比。本文特别考虑了将离散样本大小与逆温度相关联的提议[C. H. LaMont and P. A. Wiggins, Phys. Rev. E 99, 052140 (2019)]。之前的研究表明,结合这种相似性可以推导出热力学函数的类似物,如能量和熵。该研究还预计,这些类似函数有可能从物理角度描述贝叶斯估计,并为估计机制提供物理见解。本文将宏观视角作为与热力学极限类似的渐近线纳入了前述建议。其动机源于统计力学概念,即导出表征宏观系统宏观特性的热力学函数。这种纳入不仅允许考虑宏观热力学函数的类似物,而且还提出了具有连续性的逆温度类似物的候选方案,这与之前提出的将离散样本大小与逆温度联系起来的建议在一定程度上是一致的。根据这一建议,我们分析了贝叶斯线性回归模型的宏观热力学函数类似物,该模型是各种机器学习模型的基础。通过这些函数的行为,我们进一步研究了如何从物理学的角度描述贝叶斯估计,以及获得了什么样的物理启示。结果发现,回归的主要任务--回归系数的估计,似乎可以用热力学系统平衡状态下能量递减和熵增加之间平衡的物理图景来描述。更具体地说,我们观察到贝叶斯推理的物理观点如下:在低温时,当能量递减效应占主导地位时,估计就会成功。另一方面,当高温时熵增效应占主导地位时,估计就会失败。
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引用次数: 0
Stability of pairwise social dilemma games: Destructive agents, constructive agents, and their joint effects 成对社会两难博弈的稳定性:破坏性代理、建设性代理及其联合效应
IF 2.4 3区 物理与天体物理 Q1 Mathematics Pub Date : 2024-09-09 DOI: 10.1103/physreve.110.034307
Khadija Khatun, Chen Shen, Lei Shi, Jun Tanimoto
Destructive agents, who opt out of the game and indiscriminately harm others, paradoxically foster cooperation, representing an intriguing variant of the voluntary participation strategy. Yet, their impact on cooperation remains inadequately understood, particularly in the context of pairwise social dilemma games and in comparison to their counterparts, constructive agents, who opt out of the game but indiscriminately benefit others. Furthermore, little is known about the combined effects of both agent types on cooperation dynamics. Using replicator dynamics in infinite and well-mixed populations, we find that contrary to their role in facilitating cooperation in multiplayer games, destructive agents fail to encourage cooperation in pairwise social dilemmas. Instead, they replace defection in the prisoners' dilemma and stag-hunt games. Similarly, in the chicken game, they can destabilize or replace the mixed equilibrium of cooperation and defection, undermining cooperation in the harmony (trivial) game. Conversely, constructive agents, when their payoffs exceed their contributions to opponents, can exhibit effects similar to destructive agents. However, if their payoffs are lower, while they destabilize defection in prisoners' dilemma and stag-hunt games, they do not disrupt the cooperation equilibrium in harmony games and have a negligible impact on the coexistence of cooperation in chicken games. The combination of destructive and constructive agents does not facilitate cooperation, but instead generates complex evolutionary dynamics, including bistable, tristable, and quadstable states, with outcomes contingent on their relative payoffs and game types. These results, taken together, enhance our understanding of the impact of the voluntary participation mechanism on cooperation, contributing to a more comprehensive understanding of its influence.
选择退出博弈并不分青红皂白地伤害他人的破坏性行为主体,自相矛盾地促进了合作,是自愿参与策略的一个有趣变体。然而,人们对它们对合作的影响仍然了解不足,尤其是在成对社会两难博弈的背景下,以及与选择退出博弈但不分青红皂白地使他人受益的建设性代理人相比。此外,人们对这两种代理类型对合作动态的综合影响知之甚少。通过在无限且混合良好的种群中使用复制器动力学,我们发现,与破坏性代理在多人游戏中促进合作的作用相反,破坏性代理在成对社会困境中并不能鼓励合作。相反,它们在囚徒困境和猎鹿游戏中取代了叛逃。同样,在吃鸡游戏中,破坏性代理可以破坏或取代合作与叛逃的混合平衡,破坏和谐(琐碎)游戏中的合作。相反,当建设性博弈者的回报超过他们对对手的贡献时,他们会表现出与破坏性博弈者类似的效果。然而,如果他们的报酬较低,虽然他们会破坏囚徒困境和猎鹿博弈中的叛逃,却不会破坏和谐博弈中的合作均衡,而且对吃鸡博弈中的合作共存影响微乎其微。破坏性代理和建设性代理的结合不会促进合作,反而会产生复杂的演化动态,包括双稳态、三稳态和四稳态,其结果取决于它们的相对回报和博弈类型。这些结果合在一起,加深了我们对自愿参与机制对合作的影响的理解,有助于我们更全面地认识自愿参与机制的影响。
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引用次数: 0
Emergence of vertical diversity under disturbance 干扰下垂直多样性的出现
IF 2.4 3区 物理与天体物理 Q1 Mathematics Pub Date : 2024-09-06 DOI: 10.1103/physreve.110.034114
Yuya Shishikura, Hiroki Ohta
We propose a statistical physics model of a neutral community, where each agent can represent identical plant species growing in the vertical direction with sunlight in the form of rich-get-richer competition. Disturbance added to this ecosystem, which makes an agent restart from the lowest growth level, is realized as a stochastic resetting. We show that in this model for sufficiently strong competition, vertical diversity characterized by a family of Hill numbers robustly emerges as a local maximum at intermediate disturbance.
我们提出了一个中性群落的统计物理模型,其中每个代理可以代表垂直方向上生长的相同植物物种,它们在阳光下以 "富者愈富 "的竞争形式生长。在这个生态系统中加入的干扰会使一个代理从最低的生长水平重新开始,这种干扰是以随机重置的形式实现的。我们的研究表明,在这个竞争足够激烈的模型中,以希尔数家族为特征的垂直多样性会在中间干扰时稳健地出现局部最大值。
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引用次数: 0
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