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Harnessing hemostasis to transform surgical scars into CAR-T immunological niches. 利用止血将手术疤痕转化为CAR-T免疫龛。
IF 9.1 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-10 Epub Date: 2026-02-02 DOI: 10.1073/pnas.2535463123
Xiao Cheng, Ke Cheng
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引用次数: 0
Correction for Vierock et al., Multicolor photoreactions of the red light-activated channelrhodopsin Chrimson. 校正Vierock等人,红光激活通道视紫红质的多色光反应。
IF 9.1 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-10 Epub Date: 2026-02-02 DOI: 10.1073/pnas.2600938123
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引用次数: 0
Correction for Curtis et al., Fragmentation signatures in cancer patients resemble those of patients with vascular or autoimmune diseases. 对Curtis等人的更正,癌症患者的碎片特征类似于血管或自身免疫性疾病患者。
IF 9.1 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-10 Epub Date: 2026-02-02 DOI: 10.1073/pnas.2538063123
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引用次数: 0
Flagellar rotation comes full circle. 鞭毛的旋转是完整的。
IF 9.1 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-10 Epub Date: 2026-02-02 DOI: 10.1073/pnas.2533096123
Michael D Manson
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引用次数: 0
Correction Paschou et al., Dysregulated proteostasis in p.A53T-α-Synuclein astrocytes aggravates Lewy-like neuropathology in a Parkinson's disease iPSC model. Paschou等,帕金森氏病iPSC模型中p.A53T-α-突触核蛋白星形细胞的蛋白平衡失调加重了路易样神经病理。
IF 9.1 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-10 Epub Date: 2026-02-06 DOI: 10.1073/pnas.2601834123
{"title":"Correction Paschou et al., Dysregulated proteostasis in p.A53T-α-Synuclein astrocytes aggravates Lewy-like neuropathology in a Parkinson's disease iPSC model.","authors":"","doi":"10.1073/pnas.2601834123","DOIUrl":"https://doi.org/10.1073/pnas.2601834123","url":null,"abstract":"","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"123 6","pages":"e2601834123"},"PeriodicalIF":9.1,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146132987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to Compton et al.: Another paradoxical misunderstanding. 回复康普顿等人:另一个矛盾的误解。
IF 9.1 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-10 Epub Date: 2026-02-02 DOI: 10.1073/pnas.2536185123
George Butler, Joanna Baker, Sarah R Amend, Kenneth J Pienta, Chris Venditti
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引用次数: 0
Rapid evolution reveals long-range spread of SARS-CoV-2. 快速进化揭示了SARS-CoV-2的长期传播。
IF 9.1 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-10 Epub Date: 2026-02-03 DOI: 10.1073/pnas.2533093123
Daniel B Weissman
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引用次数: 0
Genuine learning biases persist after accounting for temporally decreasing learning rates: Insight from fitting six datasets. 真正的学习偏差在考虑暂时降低的学习率后仍然存在:来自拟合六个数据集的见解。
IF 9.1 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-10 Epub Date: 2026-02-03 DOI: 10.1073/pnas.2534141123
Romane Cecchi, Stefano Palminteri
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引用次数: 0
Reply to Cecchi and Palminteri: On the need to model temporal variation in learning rates. 回复Cecchi和Palminteri:关于对学习率的时间变化建模的必要性。
IF 9.1 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-10 Epub Date: 2026-02-03 DOI: 10.1073/pnas.2535857123
Prakhar Godara
{"title":"Reply to Cecchi and Palminteri: On the need to model temporal variation in learning rates.","authors":"Prakhar Godara","doi":"10.1073/pnas.2535857123","DOIUrl":"https://doi.org/10.1073/pnas.2535857123","url":null,"abstract":"","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"123 6","pages":"e2535857123"},"PeriodicalIF":9.1,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Climate-driven reduction in biomass production of the Eurasian steppe coincides with nomadic migration during the first millennium CE 气候导致的欧亚草原生物量减少与公元第一个千年的游牧人口迁移相吻合
IF 11.1 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-09 DOI: 10.1073/pnas.2513573123
Feng Chen, Xiaoen Zhao, Weipeng Yue, Shijie Wang, Yong Zhang, Youping Chen, Mao Hu, Jan Esper, Ulf Büntgen, Fredrik Charpentier Ljungqvist, Amy E. Hessl, Max C. A. Torbenson, Yujiang Yuan, Martín A. Hadad, Fidel A. Roig, Honghua Cao, Heli Zhang, Yaqun Liang, Fahu Chen
Although it is generally accepted today that climate and other environmental factors affected past human societies at different spatiotemporal scales, direct linkages are difficult to determine, and correlation should not be confused with causation. Here, we use a tree-ring width network of multimillennial chronologies from inner Eurasia to reconstruct annual changes in Net Primary Productivity (NPP) back to 200 BCE. Our findings reveal that episodes of reduced NPP around the 70s–100s, 360s–380s, and 470s–560s CE likely contributed to the westward and southward migration of nomadic people from their homelands in northwestern China and Mongolia. Although prolonged multidecadal periods of climate-induced low NPP served as tipping points for agricultural and pastoral subsistence systems, the inherent mobility of nomadic communities not only enabled them to adapt to adverse environmental conditions but also facilitated a widespread dispersal of ethnic groups.
尽管气候和其他环境因子在不同时空尺度上影响了过去的人类社会,但直接联系难以确定,相关性不应与因果关系相混淆。在这里,我们使用欧亚大陆内部千年年表的树轮宽度网络来重建净初级生产力(NPP)的年变化,可追溯到公元前200年。我们的研究结果表明,大约在公元70 - 100年代、360 - 380年代和470 - 560年代,NPP的减少可能导致了游牧民族从中国西北和蒙古的家乡向西和向南迁移。虽然气候导致的长期低NPP是农业和游牧生存系统的引爆点,但游牧社区固有的流动性不仅使他们能够适应不利的环境条件,而且还促进了族群的广泛分散。
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引用次数: 0
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Proceedings of the National Academy of Sciences of the United States of America
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