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Survival analysis of Portuguese SMEs: A preliminary approach 葡萄牙中小企业的生存分析:初步探讨
Ana Borges, M. Machado, F. Duarte
A high rate of corporate bankruptcy can be devastating to economic and entrepreneurial ecosystem, especially among countries with a high concentration of Micro, Small and Medium Sized Enterprises (SMEs). Most bankruptcy studies focus on large companies, ignoring the fact that SMEs play a key role in achieving the objectives of job creation and economic growth, which are particularly relevant in the peripheral countries of the European Union. Considering the relevance of these companies to the Portuguese economy and the scarcity of empirical studies, in this paper we offer a preliminary study about the determinants of survival of SMEs operating in Portugal. Unlike to the traditional models (i.e., static models tending to ignore the longitudinal factor of time to predict corporate bankruptcy) this study applies the Cox proportional risk model in order to predict, based on historical data taken from SABI, the probability whether a SME will be in financial distress. Using data between 2008-18 and controlling for spatial effect (Region), Size and Activity Sector, we found evidences on the negative relation between ownership concentration and financial distress.
企业破产率高可能对经济和创业生态系统造成破坏性影响,特别是在微型、小型和中型企业高度集中的国家。大多数破产研究集中在大公司,忽视了中小企业在实现创造就业和经济增长目标方面发挥关键作用的事实,这在欧盟外围国家尤为重要。考虑到这些公司与葡萄牙经济的相关性以及实证研究的稀缺性,在本文中,我们对在葡萄牙经营的中小企业的生存决定因素进行了初步研究。与传统模型(即静态模型倾向于忽略时间的纵向因素来预测企业破产)不同,本研究采用Cox比例风险模型,以SABI的历史数据为基础,预测中小企业是否陷入财务困境的概率。利用2008- 2018年的数据,在控制空间效应(地区)、规模和活动部门的情况下,我们发现了股权集中度与财务困境之间存在负相关关系的证据。
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引用次数: 1
Molecular dynamics simulation of myopathy-related mutant FHL1 in water and analysis of structure stabilization 肌病相关突变体FHL1在水中的分子动力学模拟及结构稳定性分析
H. Takeuchi, H. Okajima, H. Itoga, K. Nobuoka, Hironao Yamada, T. Miyakawa, R. Morikawa, Y. Hayashi, M. Takasu
Mutations in the FHL1 gene can cause X-linked hereditary myopathy, which causes one of the rarest intractable diseases. The age of the disease onset is quite variable from early infancy to adulthood, and the patients show progressive muscle weakness and atrophy. The FHL1 protein is constituted by four and a half LIM domains. Each LIM domain contains two zinc fingers, which contribute to the structural stability of the LIM domain. A change in the cysteine or histidine residues in the 2nd LIM domain (LIM2) is closely associated with the disease severity. Therefore, LIM2 is suggested to have an essential role in maintaining the structure of FHL1. In this study, molecular dynamics simulation was performed on molecular models consisting of LIM1 and LIM2 of wild and mutant FHL1. We calculated the extent of distortion of zinc finger structure and measured the distance between zinc atom and Cα atom of zinc-coordinated residues. Our analysis showed that the correlation between these two quantities is larger in the mutants associated with severe myopathy.Mutations in the FHL1 gene can cause X-linked hereditary myopathy, which causes one of the rarest intractable diseases. The age of the disease onset is quite variable from early infancy to adulthood, and the patients show progressive muscle weakness and atrophy. The FHL1 protein is constituted by four and a half LIM domains. Each LIM domain contains two zinc fingers, which contribute to the structural stability of the LIM domain. A change in the cysteine or histidine residues in the 2nd LIM domain (LIM2) is closely associated with the disease severity. Therefore, LIM2 is suggested to have an essential role in maintaining the structure of FHL1. In this study, molecular dynamics simulation was performed on molecular models consisting of LIM1 and LIM2 of wild and mutant FHL1. We calculated the extent of distortion of zinc finger structure and measured the distance between zinc atom and Cα atom of zinc-coordinated residues. Our analysis showed that the correlation between these two quantities is larger in the...
FHL1基因的突变可引起x连锁遗传性肌病,这是一种罕见的顽固性疾病。从婴儿期早期到成年期,发病年龄变化很大,患者表现为进行性肌肉无力和萎缩。FHL1蛋白由四个半LIM结构域组成。每个LIM结构域包含两个锌指,这有助于LIM结构域的结构稳定性。第二LIM结构域(LIM2)中半胱氨酸或组氨酸残基的改变与疾病严重程度密切相关。因此,我们认为LIM2在维持FHL1的结构中起着重要的作用。本研究对野生型和突变型FHL1的LIM1和LIM2组成的分子模型进行了分子动力学模拟。计算了锌指结构的变形程度,测量了锌配位残基中锌原子与Cα原子之间的距离。我们的分析表明,在与严重肌病相关的突变体中,这两个数量之间的相关性更大。FHL1基因的突变可引起x连锁遗传性肌病,这是一种罕见的顽固性疾病。从婴儿期早期到成年期,发病年龄变化很大,患者表现为进行性肌肉无力和萎缩。FHL1蛋白由四个半LIM结构域组成。每个LIM结构域包含两个锌指,这有助于LIM结构域的结构稳定性。第二LIM结构域(LIM2)中半胱氨酸或组氨酸残基的改变与疾病严重程度密切相关。因此,我们认为LIM2在维持FHL1的结构中起着重要的作用。本研究对野生型和突变型FHL1的LIM1和LIM2组成的分子模型进行了分子动力学模拟。计算了锌指结构的变形程度,测量了锌配位残基中锌原子与Cα原子之间的距离。我们的分析表明,这两个量之间的相关性在…
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引用次数: 0
Piecewise constant control approximations in the problem on effective resource consumption 有效资源消耗问题的分段常数控制逼近
A. Tarasyev, A. Usova
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引用次数: 1
Parametric analysis on the seismic response of masonry bell towers 砌体钟楼地震反应参数分析
A. Formisano, F. Fabbrocino, G. Vaiano
The Italy is a country rich of historical buildings, often made up of bricks, which were seriously damaged or suffered collapse after recent devastating earthquakes. In this framework the current work shows the results of instrumental researches and structural analysis aiming at the description of the seismic behaviour of masonry belfries or bell towers. Forty case studies belonging to thirteen Italian regions, so to be representative of the different seismic areas of the country, have been herein examined. A global modelling approach based on macro-elements models able to reproduce the seismic behaviour of bell towers with the support of the equivalent frame technique has been implemented through the 3MURI software. This numerical approach has allowed to reproduce the sequence of the main damage mechanisms of structures as horizontal forces increase. Therefore, a parametric analysis has been performed to evaluate the seismic response of investigated structures by changing their geometrical parameters. From the achieved results the individuation of the bell towers most at risk placed in different parts of Italy (North, Centre and South) has been faced. Finally, a new third order polynomial formula is proposed to calculate the principal vibration period of light squared stone towers as a function of their slenderness.The Italy is a country rich of historical buildings, often made up of bricks, which were seriously damaged or suffered collapse after recent devastating earthquakes. In this framework the current work shows the results of instrumental researches and structural analysis aiming at the description of the seismic behaviour of masonry belfries or bell towers. Forty case studies belonging to thirteen Italian regions, so to be representative of the different seismic areas of the country, have been herein examined. A global modelling approach based on macro-elements models able to reproduce the seismic behaviour of bell towers with the support of the equivalent frame technique has been implemented through the 3MURI software. This numerical approach has allowed to reproduce the sequence of the main damage mechanisms of structures as horizontal forces increase. Therefore, a parametric analysis has been performed to evaluate the seismic response of investigated structures by changing their geometrical parameters. Fr...
意大利是一个拥有许多历史建筑的国家,这些建筑通常是由砖块构成的,在最近的毁灭性地震后严重受损或倒塌。在这个框架下,目前的工作显示了旨在描述砌体钟楼或钟楼抗震性能的仪器研究和结构分析的结果。本文研究了来自意大利13个地区的40个案例,以代表意大利不同的地震区。在等效框架技术的支持下,通过3MURI软件实现了一种基于宏观元素模型的全球建模方法,能够再现钟楼的地震行为。这种数值方法可以重现结构在水平力增加时的主要损伤机制序列。因此,通过改变结构的几何参数,对结构的地震反应进行了参数化分析。从已取得的成果来看,意大利不同地区(北部、中部和南部)最危险的钟楼的个性化已经面临。最后,提出了一个新的三阶多项式公式来计算轻方石塔的主振动周期作为其长细的函数。意大利是一个拥有许多历史建筑的国家,这些建筑通常是由砖块构成的,在最近的毁灭性地震后严重受损或倒塌。在这个框架下,目前的工作显示了旨在描述砌体钟楼或钟楼抗震性能的仪器研究和结构分析的结果。本文研究了来自意大利13个地区的40个案例,以代表意大利不同的地震区。在等效框架技术的支持下,通过3MURI软件实现了一种基于宏观元素模型的全球建模方法,能够再现钟楼的地震行为。这种数值方法可以重现结构在水平力增加时的主要损伤机制序列。因此,通过改变结构的几何参数,对结构的地震反应进行了参数化分析。Fr……
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引用次数: 3
Kinetics of hemolysis induced by thioridazine 硫硝嗪诱导溶血动力学
Bilyana Tacheva, B. Paarvanova, Stanislav Bozhikov, I. Ivanov, M. Karabaliev
The process of hemolysis of erythrocyte suspension induced by thioridazine (TDZ) was investigated by measuring the UV-Vis absorbance spectrum in the range 200 nm - 700 nm. The time needed to obtain the spectrum in this range was 12.5 s, so the spectrum was measured each 15 s. This permitted to follow the changes in absorbance at different wavelengths of the spectra during hemolysis. It was found that at most of the wavelengths measured the absorbance decreased which was related to the decrease of the light-scattering by the intact erythrocytes. In contrast, the absorbance peak of the hemoglobin (Hb) at 416 nm increased significantly during hemolysis. This was attributed to smaller light absorption by Hb when the erythrocytes were still intact and the Hb is still inside the erythrocytes. This phenomenon was due to the forward-scattered light that did not penetrate the erythrocytes and did not interact with Hb. When Hb was released from erythrocytes it could already interact with the light, resulting in increase of the absorption peaks of Hb and especially of the peak at 416 nm. The kinetics of the decrease of light-scattering at 700 nm and 500 nm and the increase of Hb absorption at 416 nm were compared and it was found that they are directly related. The kinetics of hemolysis induced by different concentrations of TDZ were measured. It was found that the time for hemolysis depended on the TDZ concentration as power function with power factor of minus 5.The process of hemolysis of erythrocyte suspension induced by thioridazine (TDZ) was investigated by measuring the UV-Vis absorbance spectrum in the range 200 nm - 700 nm. The time needed to obtain the spectrum in this range was 12.5 s, so the spectrum was measured each 15 s. This permitted to follow the changes in absorbance at different wavelengths of the spectra during hemolysis. It was found that at most of the wavelengths measured the absorbance decreased which was related to the decrease of the light-scattering by the intact erythrocytes. In contrast, the absorbance peak of the hemoglobin (Hb) at 416 nm increased significantly during hemolysis. This was attributed to smaller light absorption by Hb when the erythrocytes were still intact and the Hb is still inside the erythrocytes. This phenomenon was due to the forward-scattered light that did not penetrate the erythrocytes and did not interact with Hb. When Hb was released from erythrocytes it could already interact with the light, resulting in inc...
采用紫外-可见光谱法在200 ~ 700 nm范围内研究了噻嗪(TDZ)对红细胞悬浮液的溶血作用。获得该范围内的光谱所需时间为12.5 s,因此每15 s测量一次光谱。这样可以跟踪溶血过程中光谱不同波长处吸光度的变化。结果表明,在大多数波长处,吸光度都有所下降,这与完整红细胞的光散射减少有关。血红蛋白(Hb)在416 nm处的吸光度峰在溶血过程中显著升高。这是由于当红细胞仍完整且Hb仍在红细胞内时,Hb对光的吸收较小。这种现象是由于前向散射光没有穿透红细胞,也没有与血红蛋白相互作用。当Hb从红细胞中释放出来时,它已经可以与光相互作用,导致Hb的吸收峰增加,特别是在416 nm处的吸收峰。比较了在700 nm和500 nm处光散射降低和在416 nm处Hb吸收增加的动力学,发现两者有直接关系。测定了不同浓度TDZ诱导溶血的动力学。结果表明,溶血时间与TDZ浓度呈幂函数关系,幂因子为- 5。采用紫外-可见光谱法在200 ~ 700 nm范围内研究了噻嗪(TDZ)对红细胞悬浮液的溶血作用。获得该范围内的光谱所需时间为12.5 s,因此每15 s测量一次光谱。这样可以跟踪溶血过程中光谱不同波长处吸光度的变化。结果表明,在大多数波长处,吸光度都有所下降,这与完整红细胞的光散射减少有关。血红蛋白(Hb)在416 nm处的吸光度峰在溶血过程中显著升高。这是由于当红细胞仍完整且Hb仍在红细胞内时,Hb对光的吸收较小。这种现象是由于前向散射光没有穿透红细胞,也没有与血红蛋白相互作用。当血红蛋白从红细胞中释放出来时,它已经可以与光相互作用,从而导致…
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引用次数: 3
Proton conducting mechanism in perovskite metal oxides from viewpoints of local structural relaxation and local chemical bonding change 从局部结构弛豫和局部化学键变化的角度看钙钛矿金属氧化物中的质子传导机理
T. Onishi
From our previous molecular orbital calculations using hybrid density functional theory for proton-conducting perovskite metal oxides, it was found that proton pumping effect is combined during proton-conduction, and covalent bonding change occurs in a diagonal line. It is known that pure perovskite metal oxides are regarded as boundary system. It is because they consist of the same unit structures. However, during proton-conduction, both local structural relaxation and local chemical bonding change must be taken into consideration. In this paper, the proton-conducting mechanism is explained from the different viewpoints of local structural relaxation and local chemical bonding change.From our previous molecular orbital calculations using hybrid density functional theory for proton-conducting perovskite metal oxides, it was found that proton pumping effect is combined during proton-conduction, and covalent bonding change occurs in a diagonal line. It is known that pure perovskite metal oxides are regarded as boundary system. It is because they consist of the same unit structures. However, during proton-conduction, both local structural relaxation and local chemical bonding change must be taken into consideration. In this paper, the proton-conducting mechanism is explained from the different viewpoints of local structural relaxation and local chemical bonding change.
我们利用杂化密度泛函理论计算质子传导钙钛矿金属氧化物的分子轨道,发现质子传导过程中质子泵送效应结合在一起,共价键变化以对角线形式发生。已知纯钙钛矿金属氧化物被视为边界体系。这是因为它们由相同的单位结构组成。然而,在质子传导过程中,必须同时考虑到局部结构弛豫和局部化学键的变化。本文从局域结构弛豫和局域化学键变化的不同角度解释了质子的传导机理。我们利用杂化密度泛函理论计算质子传导钙钛矿金属氧化物的分子轨道,发现质子传导过程中质子泵送效应结合在一起,共价键变化以对角线形式发生。已知纯钙钛矿金属氧化物被视为边界体系。这是因为它们由相同的单位结构组成。然而,在质子传导过程中,必须同时考虑到局部结构弛豫和局部化学键的变化。本文从局域结构弛豫和局域化学键变化的不同角度解释了质子的传导机理。
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引用次数: 0
A statistical contribution on the film tourism. A case study 对电影旅游的统计贡献。案例研究
H. Sol, L. Grilo, J. P. Coelho
The evaluation of the impact that the images perceived by the spectators have in the destination choices they make as tourists is a growing research field, not only in Tourism and Marketing Management but also among the Behavioural Sciences. Based on a questionnaire previously developed on a Film Tourism sub-project, with qualitative variables in nominal and ordinal scale, a survey was conducted during a number of film screenings hosted by Tomar’s (a medium-sized city in Portugal) Film Society. After the characterization of the random sample with the sociodemographic variables, the nonparametric test Pearson chi-square was applied to test the null hypothesis of independence between the variable “Gender” and the variables “Have you ever visited a place by influence of a film?” or “Destination-dream by strong influence of a film”. Given that the null hypothesis is not rejected, there is no statistical evidence to consider a dependence/relationship between these variables. Other finding is statistically significant Spearman correlations between some variables, such as “Education level” and “The average number of activities of Film Tourism”.The evaluation of the impact that the images perceived by the spectators have in the destination choices they make as tourists is a growing research field, not only in Tourism and Marketing Management but also among the Behavioural Sciences. Based on a questionnaire previously developed on a Film Tourism sub-project, with qualitative variables in nominal and ordinal scale, a survey was conducted during a number of film screenings hosted by Tomar’s (a medium-sized city in Portugal) Film Society. After the characterization of the random sample with the sociodemographic variables, the nonparametric test Pearson chi-square was applied to test the null hypothesis of independence between the variable “Gender” and the variables “Have you ever visited a place by influence of a film?” or “Destination-dream by strong influence of a film”. Given that the null hypothesis is not rejected, there is no statistical evidence to consider a dependence/relationship between these variables. Other finding is statistically sign...
评估观众所感知的图像对他们作为游客所做的目的地选择的影响是一个不断发展的研究领域,不仅在旅游和营销管理领域,而且在行为科学领域。基于先前在电影旅游子项目上开发的问卷调查,在名义和有序尺度上的定性变量,在托马尔(葡萄牙的一个中等城市)电影协会主办的一些电影放映期间进行了一项调查。在用社会人口学变量对随机样本进行表征后,应用非参数检验皮尔逊卡方检验变量“性别”与变量“您是否曾受电影影响去过某个地方?”或“受电影强烈影响的目的地梦”。鉴于零假设没有被拒绝,没有统计证据可以考虑这些变量之间的依赖/关系。另一个发现是统计上显著的Spearman相关性在一些变量之间,如“教育水平”和“电影旅游活动的平均数量”。评估观众所感知的图像对他们作为游客所做的目的地选择的影响是一个不断发展的研究领域,不仅在旅游和营销管理领域,而且在行为科学领域。基于先前在电影旅游子项目上开发的问卷调查,在名义和有序尺度上的定性变量,在托马尔(葡萄牙的一个中等城市)电影协会主办的一些电影放映期间进行了一项调查。在用社会人口学变量对随机样本进行表征后,应用非参数检验皮尔逊卡方检验变量“性别”与变量“您是否曾受电影影响去过某个地方?”或“受电影强烈影响的目的地梦”。鉴于零假设没有被拒绝,没有统计证据可以考虑这些变量之间的依赖/关系。其他发现是统计学上的迹象……
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引用次数: 0
Contribution to individualized environmental education 对个性化环境教育的贡献
Aspasia Karagiannopoulou, F. Batzias, O. Kopsidas
In this work, we modify the Holland’ s methodology for the categorization of human personalities by including queries (in the corresponding questionnaire that serves as an evaluation tool) investigating its responders attitude as regards his/her willingness to be professionally engaged with the natural or/and anthropogenic environment. The population used as representative sample consisted of 250 students following courses at high school and university level. The quantitative methods used were descriptive statistics, parametric and non-parametric statistics hypothesis (on causal relations) testing, categorical semantics, ontological mapping fuzzy sets and interval algebra. The results obtained showed relative significant internal consistency at macro-level for almost half of the interviewees, but the dependence of answers to environmental queries on the rest responds to the rest queries was insignificant, indicating lack of specific knowledge and clarification of the corresponding concepts at micro-level.In this work, we modify the Holland’ s methodology for the categorization of human personalities by including queries (in the corresponding questionnaire that serves as an evaluation tool) investigating its responders attitude as regards his/her willingness to be professionally engaged with the natural or/and anthropogenic environment. The population used as representative sample consisted of 250 students following courses at high school and university level. The quantitative methods used were descriptive statistics, parametric and non-parametric statistics hypothesis (on causal relations) testing, categorical semantics, ontological mapping fuzzy sets and interval algebra. The results obtained showed relative significant internal consistency at macro-level for almost half of the interviewees, but the dependence of answers to environmental queries on the rest responds to the rest queries was insignificant, indicating lack of specific knowledge and clarification of the corresponding concepts at micro-level.
在这项工作中,我们修改了荷兰的人格分类方法,包括询问(在作为评估工具的相应问卷中)调查其响应者的态度,以及他/她是否愿意专业地参与自然或/和人为环境。作为代表性样本的人口包括250名在高中和大学学习课程的学生。定量方法包括描述性统计、参数统计和非参数统计假设(因果关系)检验、范畴语义、本体映射模糊集和区间代数。结果显示,几乎一半的受访者在宏观层面上具有相对显著的内部一致性,但对环境问题的回答对其他问题的回答的依赖性不显著,表明在微观层面上缺乏相应的具体知识和概念的澄清。在这项工作中,我们修改了荷兰的人格分类方法,包括询问(在作为评估工具的相应问卷中)调查其响应者的态度,以及他/她是否愿意专业地参与自然或/和人为环境。作为代表性样本的人口包括250名在高中和大学学习课程的学生。定量方法包括描述性统计、参数统计和非参数统计假设(因果关系)检验、范畴语义、本体映射模糊集和区间代数。结果显示,几乎一半的受访者在宏观层面上具有相对显著的内部一致性,但对环境问题的回答对其他问题的回答的依赖性不显著,表明在微观层面上缺乏相应的具体知识和概念的澄清。
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引用次数: 0
Preface of the Session: ‘Allometry and Scaling in Medicine, Biophysics and Ecology’ 会议序言:“医学、生物物理学和生态学中的异速生长和标度”
A. Atanasov
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引用次数: 0
The numerical studies of the multi-stage damage behavior of an explosively-driven HR2 cylinder 爆炸驱动HR2气缸多级损伤行为的数值研究
Jia Yuxi, Jian Songqing, L. Wentao, Xiong Jun
The damage in the metallic thick-walled cylinder expanded by explosive load is highly complicated and is particularly important to the design of munitions and armaments. A serial of experiments with different strain rate in steel have been done to explore the fracture behavior in the metallic cylinder [1] ∼ [8]. Figure 1 shows the sketch of the experimental specimen and the field [8]. The experimental results in the Fig. 2 revealed that the shear fracture was dominant while the cylinder deformed at a high strain rate [1], [3]. As the Fig.3, the recovered fragments showed the damage in the cylinder contained many fracture mechanisms such as spallation, tensional fraction and adiabatic shear band [3].The damage in the metallic thick-walled cylinder expanded by explosive load is highly complicated and is particularly important to the design of munitions and armaments. A serial of experiments with different strain rate in steel have been done to explore the fracture behavior in the metallic cylinder [1] ∼ [8]. Figure 1 shows the sketch of the experimental specimen and the field [8]. The experimental results in the Fig. 2 revealed that the shear fracture was dominant while the cylinder deformed at a high strain rate [1], [3]. As the Fig.3, the recovered fragments showed the damage in the cylinder contained many fracture mechanisms such as spallation, tensional fraction and adiabatic shear band [3].
金属厚壁圆筒在爆炸载荷作用下的损伤是一个非常复杂的问题,对弹药和武器装备的设计具有重要意义。为了研究金属圆柱体在不同应变速率下的断裂行为,进行了一系列试验[1]~[8]。图1为实验试件及现场示意图[8]。从图2的实验结果可以看出,在高应变速率下圆筒变形以剪切断裂为主[1],[3]。从图3中可以看出,圆柱体内部的损伤包含了多种断裂机制,如散裂、张拉分数和绝热剪切带等[3]。金属厚壁圆筒在爆炸载荷作用下的损伤是一个非常复杂的问题,对弹药和武器装备的设计具有重要意义。为了研究金属圆柱体在不同应变速率下的断裂行为,进行了一系列试验[1]~[8]。图1为实验试件及现场示意图[8]。从图2的实验结果可以看出,在高应变速率下圆筒变形以剪切断裂为主[1],[3]。从图3中可以看出,圆柱体内部的损伤包含了多种断裂机制,如散裂、张拉分数和绝热剪切带等[3]。
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引用次数: 0
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PROCEEDINGS OF THE INTERNATIONAL CONFERENCE OF COMPUTATIONAL METHODS IN SCIENCES AND ENGINEERING 2019 (ICCMSE-2019)
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