Pub Date : 2023-09-01DOI: 10.29235/1814-6023-2023-20-3-191-204
А.Г. Кадушкин, А. Д. Таганович, Л. В. Мовчан, М. М. Зафранская, Т. В. Шман, A. Kadushkin, A. Tahanovich, L. Movchan, Marina M. Zafranskaya, T. Shman
The inflammatory process specific for chronic obstructive pulmonary disease (COPD) is accompanied by T lymphocyte migration from peripheral blood to the respiratory tract. Suppression of T cell chemotaxis by drugs may attenuate the inflammatory response in patients with COPD.The aim of this study was to determine the ability of azithromycin in combination with glucocorticoids to affect the migration of blood T cells in patients with COPD.The percentage of T lymphocytes expressing chemokine receptors CCR5, CCR6, CCR7, CXCR3, CXCR4, CXCR6 was analyzed by flow cytometry in the peripheral blood of 54 smokers with COPD, 21 healthy smokers, and 20 healthy non-smokers, as well as in bronchoalveolar lavage (BAL) of 7 smokers with COPD and 7 healthy smokers. Additionally, we determined the effect of azithromycin (10 μg/ml) and budesonide (10 nM) on the migration of peripheral blood T helper cells and cytotoxic T lymphocytes from patients with COPD (n = 8) to chemokines RANTES (10 nM) and IP-10 (10 nM).The percentage of T lymphocytes expressing chemokine receptors CXCR3 and CCR5 increased in the peripheral blood of COPD smokers compared with healthy smokers and healthy non-smokers, as well as in the BAL of COPD smokers compared with healthy smokers. The proportion of T cells expressing chemokine receptors CXCR4, CXCR6, CCR6, and CCR7 did not differ in the peripheral blood and the BAL between COPD patients and healthy controls. Budesonide only inhibited the migration of cytotoxic T lymphocytes to RANTES. Azithromycin, alone and combined with budesonide, inhibited the migration of T helper cells and cytotoxic T lymphocytes to both RANTES and IP-10. Moreover, the inhibitory effect of azithromycin, in combination with budesonide and without it, on the T cell migration was significantly greater than the effect of budesonide alone.Our results suggest a role for CXCR3 and CCR5 in T cell recruitment into the lungs of COPD patients and demonstrate the ability of azithromycin to inhibit T lymphocyte migration.
{"title":"Impact of azithromycin on the migration of peripheral blood T lymphocytes from patients with chronic obstructive pulmonary disease to RANTES and IP-10","authors":"А.Г. Кадушкин, А. Д. Таганович, Л. В. Мовчан, М. М. Зафранская, Т. В. Шман, A. Kadushkin, A. Tahanovich, L. Movchan, Marina M. Zafranskaya, T. Shman","doi":"10.29235/1814-6023-2023-20-3-191-204","DOIUrl":"https://doi.org/10.29235/1814-6023-2023-20-3-191-204","url":null,"abstract":"The inflammatory process specific for chronic obstructive pulmonary disease (COPD) is accompanied by T lymphocyte migration from peripheral blood to the respiratory tract. Suppression of T cell chemotaxis by drugs may attenuate the inflammatory response in patients with COPD.The aim of this study was to determine the ability of azithromycin in combination with glucocorticoids to affect the migration of blood T cells in patients with COPD.The percentage of T lymphocytes expressing chemokine receptors CCR5, CCR6, CCR7, CXCR3, CXCR4, CXCR6 was analyzed by flow cytometry in the peripheral blood of 54 smokers with COPD, 21 healthy smokers, and 20 healthy non-smokers, as well as in bronchoalveolar lavage (BAL) of 7 smokers with COPD and 7 healthy smokers. Additionally, we determined the effect of azithromycin (10 μg/ml) and budesonide (10 nM) on the migration of peripheral blood T helper cells and cytotoxic T lymphocytes from patients with COPD (n = 8) to chemokines RANTES (10 nM) and IP-10 (10 nM).The percentage of T lymphocytes expressing chemokine receptors CXCR3 and CCR5 increased in the peripheral blood of COPD smokers compared with healthy smokers and healthy non-smokers, as well as in the BAL of COPD smokers compared with healthy smokers. The proportion of T cells expressing chemokine receptors CXCR4, CXCR6, CCR6, and CCR7 did not differ in the peripheral blood and the BAL between COPD patients and healthy controls. Budesonide only inhibited the migration of cytotoxic T lymphocytes to RANTES. Azithromycin, alone and combined with budesonide, inhibited the migration of T helper cells and cytotoxic T lymphocytes to both RANTES and IP-10. Moreover, the inhibitory effect of azithromycin, in combination with budesonide and without it, on the T cell migration was significantly greater than the effect of budesonide alone.Our results suggest a role for CXCR3 and CCR5 in T cell recruitment into the lungs of COPD patients and demonstrate the ability of azithromycin to inhibit T lymphocyte migration.","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83546780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.29235/1814-6023-2023-20-3-216-225
С. Г. Пашкевич, С. П. Рубникович, Т. Е. Кузнецова, Е. В. Кузьменко, Г. П. Миронова, О. Г. Тихонович, Ж. А. Гладкова, К. Н. Жогаль, Н. С. Сердюченко, А. С. Грищенков, S. Pashkevich, Sergey P . Rubnikovich, Tatyana E . Kuznetsova, Elena V . Kuzmenko, Galina P . Mironova, Olga G . Tikhonovich, Zhanna A. Gladkova, Kseniya N . Zhogal, N. S. Serdyuchenko, Arseny S . Grishchenkov
The article presents the results of structural and functional transformations in cerebellum, trigeminal nuclei, and hippocampus of male Wistar rats against the background of injection of mesenchymal stem cells (MSCs) into Meckel’s space in the temporomandibular joint (TMJ) inflammation model.The aim of the study was to clarify the effect of MSCs injections into Meckel’s space on the morphostructural features of cerebellum, trigeminal nuclei, and hippocampus in the TMJ inflammation model.Injecting the mesenchymal stem cells into Meckel’s space in an inflammatory model of the right lower temporomandibular joint promotes the structure restoration of the ganglionic layer of the cerebellum, the spinal nuclei of the trigeminal nerve, and the hippocampus of rats by the 28th day. This is manifested in increasing the neuronal density, decreasing the neurodegeneration index, and in activating glia elements.
{"title":"Morphostructural changes in the brain of experimental animals after using mesenchymal stem cells in the temporomandibular joint inflammation model","authors":"С. Г. Пашкевич, С. П. Рубникович, Т. Е. Кузнецова, Е. В. Кузьменко, Г. П. Миронова, О. Г. Тихонович, Ж. А. Гладкова, К. Н. Жогаль, Н. С. Сердюченко, А. С. Грищенков, S. Pashkevich, Sergey P . Rubnikovich, Tatyana E . Kuznetsova, Elena V . Kuzmenko, Galina P . Mironova, Olga G . Tikhonovich, Zhanna A. Gladkova, Kseniya N . Zhogal, N. S. Serdyuchenko, Arseny S . Grishchenkov","doi":"10.29235/1814-6023-2023-20-3-216-225","DOIUrl":"https://doi.org/10.29235/1814-6023-2023-20-3-216-225","url":null,"abstract":"The article presents the results of structural and functional transformations in cerebellum, trigeminal nuclei, and hippocampus of male Wistar rats against the background of injection of mesenchymal stem cells (MSCs) into Meckel’s space in the temporomandibular joint (TMJ) inflammation model.The aim of the study was to clarify the effect of MSCs injections into Meckel’s space on the morphostructural features of cerebellum, trigeminal nuclei, and hippocampus in the TMJ inflammation model.Injecting the mesenchymal stem cells into Meckel’s space in an inflammatory model of the right lower temporomandibular joint promotes the structure restoration of the ganglionic layer of the cerebellum, the spinal nuclei of the trigeminal nerve, and the hippocampus of rats by the 28th day. This is manifested in increasing the neuronal density, decreasing the neurodegeneration index, and in activating glia elements.","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85680334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.29235/1814-6023-2023-20-3-226-235
Евгения Александровна Полякова, М.В. Стёганцева, И. Е. Гурьянова, Д.В. Луцкович, Е.Я. Скоповец, А.В. Любушкин, Т. П. Володащик, В. И. Казак, Ю. В. Скибо, М.В. Белевцев, E. A. Polyakova, M. Stegantseva, I. Guryanova, Dmitry V. Lutskovich, K. Skapavets, A. Liubushkin, T. Volodashchik, Victoria I. Kazak, Yulia V. Skibo, M. V. Belevtsev
Inborn immunity errors such as primary immunodeficiencies in children represent a significant problem for public health, and it is undeniably important to improve the laboratory diagnosis of this pathology by creating new, effective methods for early detection of disorders involving immune mechanisms.The ROC analysis was used to evaluate the diagnostic significance of determining the copy number of T- and B-cell receptor DNA circle fragments (TREC/KREC) by multiplex real-time PCR in patients with a genetically determined diagnosis of primary immunodeficiency.Peripheral blood DNA samples of healthy children (n = 98) aged 0.0 (0-15.0) years, who constituted the control group, and of patients with genetically confirmed primary immunodeficiency (n = 95) aged 7.2 (0.1-18.0) years were examined.It has been established that determining the number of T and B cell receptor rearrangement products (TREC and KREC) has a high diagnostic significance in severe combined immunodeficiency, chromosomal instability syndromes such as ataxiateleangioectasia and Niimegen syndrome, diseases associated with immune dysregulation, agammoglobulinemia. Determining TREC and KREC is not informative in immunodeficiencies with non-lymphoid cell dysfunction or disorders that do not affect T- and B-cell receptor gene rearrangement such as the Wiskott-Aldrich syndrome and the chronic granulomatous disease.Determining TREC, KREC has a high diagnostic significance and can be applied in diagnosis of congenital immunity errors associated with T- and B-cell lymphopenia.
{"title":"Diagnostic significance of determining TREC and KREC T- and B-cell receptor rearrangement products in patients with inborn immune errors","authors":"Евгения Александровна Полякова, М.В. Стёганцева, И. Е. Гурьянова, Д.В. Луцкович, Е.Я. Скоповец, А.В. Любушкин, Т. П. Володащик, В. И. Казак, Ю. В. Скибо, М.В. Белевцев, E. A. Polyakova, M. Stegantseva, I. Guryanova, Dmitry V. Lutskovich, K. Skapavets, A. Liubushkin, T. Volodashchik, Victoria I. Kazak, Yulia V. Skibo, M. V. Belevtsev","doi":"10.29235/1814-6023-2023-20-3-226-235","DOIUrl":"https://doi.org/10.29235/1814-6023-2023-20-3-226-235","url":null,"abstract":"Inborn immunity errors such as primary immunodeficiencies in children represent a significant problem for public health, and it is undeniably important to improve the laboratory diagnosis of this pathology by creating new, effective methods for early detection of disorders involving immune mechanisms.The ROC analysis was used to evaluate the diagnostic significance of determining the copy number of T- and B-cell receptor DNA circle fragments (TREC/KREC) by multiplex real-time PCR in patients with a genetically determined diagnosis of primary immunodeficiency.Peripheral blood DNA samples of healthy children (n = 98) aged 0.0 (0-15.0) years, who constituted the control group, and of patients with genetically confirmed primary immunodeficiency (n = 95) aged 7.2 (0.1-18.0) years were examined.It has been established that determining the number of T and B cell receptor rearrangement products (TREC and KREC) has a high diagnostic significance in severe combined immunodeficiency, chromosomal instability syndromes such as ataxiateleangioectasia and Niimegen syndrome, diseases associated with immune dysregulation, agammoglobulinemia. Determining TREC and KREC is not informative in immunodeficiencies with non-lymphoid cell dysfunction or disorders that do not affect T- and B-cell receptor gene rearrangement such as the Wiskott-Aldrich syndrome and the chronic granulomatous disease.Determining TREC, KREC has a high diagnostic significance and can be applied in diagnosis of congenital immunity errors associated with T- and B-cell lymphopenia.","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"183 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74353666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.29235/1814-6023-2023-20-3-256-264
E. V. Kravchenko, L. M. Olgomets, O. N. Savanets, K. V. Borodina, E. S. Pustyulga, V. Golubovich, R. D. Zilberman, N. Bizunok, B. Dubovik
The effect of proline-containing oligopeptides N-Ac-DSer-Pro-DArg-Gly-NH2 (B-4), N-Ac-Trp-Pro-Arg-Gly-NH2 (B-5), N-Ac-Tyr-Pro-Arg-Gly-NH2 (B-7), and Pro-Gly on the behavior of male ICR mice in the Forced Swim Test was studied. N-Ac-DSer-Pro-DArg-Gly-NH2 (1.0 mcg/kg, i.n) increased the intensity of active swimming, most pronounced – during the last 2 minutes of testing (maximum fatigue period), i.e., it prevented the behavior of “despair”.
{"title":"Effect of proline-containing oligopeptides on the behavior of outbred ICR mice in the Forced Swim Test","authors":"E. V. Kravchenko, L. M. Olgomets, O. N. Savanets, K. V. Borodina, E. S. Pustyulga, V. Golubovich, R. D. Zilberman, N. Bizunok, B. Dubovik","doi":"10.29235/1814-6023-2023-20-3-256-264","DOIUrl":"https://doi.org/10.29235/1814-6023-2023-20-3-256-264","url":null,"abstract":"The effect of proline-containing oligopeptides N-Ac-DSer-Pro-DArg-Gly-NH2 (B-4), N-Ac-Trp-Pro-Arg-Gly-NH2 (B-5), N-Ac-Tyr-Pro-Arg-Gly-NH2 (B-7), and Pro-Gly on the behavior of male ICR mice in the Forced Swim Test was studied. N-Ac-DSer-Pro-DArg-Gly-NH2 (1.0 mcg/kg, i.n) increased the intensity of active swimming, most pronounced – during the last 2 minutes of testing (maximum fatigue period), i.e., it prevented the behavior of “despair”.","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84486314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.29235/1814-6023-2023-20-3-183-190
А. С. Доронькина, И. П. Жаворонок, В. Г. Богдан, A. S. Doronkina, I. P. Zhavoronok, Vasily G. Bogdan
The effect of fatty acid amides during the blockade of membrane orphan GPR18, GPR55 and nuclear PPARα receptors on the level of pro- and anti-inflammatory cytokines in rats with experimental peripheral neuropathy was studied. It has been proven that the anti-inflammatory action of PEA and SEA in experimental animals with neuropathy is carried out through nuclear PPARα receptors. However, PGlyA has no anti-inflamatory effects in a rat model of peripheral neuropathy.
{"title":"Profile of pro- and anti-inflammatory cytokines during injection of fatty acid amides with ethanolamine and glycine in modeling peripheral neuropathy","authors":"А. С. Доронькина, И. П. Жаворонок, В. Г. Богдан, A. S. Doronkina, I. P. Zhavoronok, Vasily G. Bogdan","doi":"10.29235/1814-6023-2023-20-3-183-190","DOIUrl":"https://doi.org/10.29235/1814-6023-2023-20-3-183-190","url":null,"abstract":"The effect of fatty acid amides during the blockade of membrane orphan GPR18, GPR55 and nuclear PPARα receptors on the level of pro- and anti-inflammatory cytokines in rats with experimental peripheral neuropathy was studied. It has been proven that the anti-inflammatory action of PEA and SEA in experimental animals with neuropathy is carried out through nuclear PPARα receptors. However, PGlyA has no anti-inflamatory effects in a rat model of peripheral neuropathy.","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"109 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79418844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.29235/1814-6023-2023-20-3-205-215
А.Н. Батян, В. Н. Волонцевич, Е. В. Гончарова, П. Д. Демешко, В.О. Лемешевский, Anatoly N. Batyan, Vitali N. Valantsevich, K. V. Hancharova, Pavel D. Dziameshka, Viktar O. Lemiasheuski
Despite the fact that head and neck tumors are very sensitive to radiation treatment, patients who have completed a course of radiation therapy have a high rate of recurrence and mortality from the underlying disease.The aim of the study was to analyze the event-free survival of patients who completed a course of radiation therapy for stage I-III head and neck cancer according to a radical program under the influence of a number of independent factors such as age, gender, total focal dose, disease stage, duration of a break in a split course of radiation therapy.The effect of the duration of interruption on survival was assessed by analyzing the treatment regimens for patients who received radiation treatment for stage I-III head and neck cancer according to a radical program from 2016 to 2018 at the Brest Regional Oncological Dispensary. Statistical processing of the obtained data included the analysis by the Cox regression method. Data were analyzed using the Kaplan-Meier method to evaluate the outcome.In the multivariate analysis, it was found that the disease stage has the greatest relationship with event-free survival (p < 0.01). The same trend is observed for the duration of interruption in radiotherapy (p < 0.05). The cumulative survival was significantly higher in the group of patients with treatment interruption of less than 3 weeks compared to the group of patients who completed treatment more than 3 weeks apart (80.00 % vs 49.06 %). If the duration of the break is less than 3 weeks, the clinical stage (T1-T3) is not a factor influencing patient survival.Accounting for the effect of interruptions in the course of radiotherapy and the understanding the influence of controllable factors is essential for optimal treatment strategies.
尽管头颈部肿瘤对放射治疗非常敏感，但完成一个疗程放射治疗的患者有很高的复发率和潜在疾病的死亡率。本研究的目的是分析在年龄、性别、总病灶剂量、疾病分期、分割放射治疗间隔时间等独立因素的影响下，根据根治方案完成一期头颈癌放疗的患者的无事件生存率。通过分析2016年至2018年在布雷斯特地区肿瘤药房接受放射治疗的I-III期头颈癌患者的治疗方案，评估了中断时间对生存的影响。所得数据的统计处理包括Cox回归分析。数据分析采用Kaplan-Meier法评价结果。在多因素分析中，发现疾病分期与无事件生存的关系最大(p < 0.01)。放疗中断时间也有相同的趋势(p < 0.05)。治疗中断时间少于3周的患者的累积生存期明显高于间隔时间超过3周的患者(80.00 % vs 49.06%)。如果中断时间少于3周，则临床分期(T1-T3)不是影响患者生存的因素。考虑放疗过程中中断的影响和了解可控因素的影响对优化治疗策略至关重要。
{"title":"Influence of interruptions in radiation therapy on long-term results of treatment of stage I-III head and neck cancers in the absence of surgical and chemoradiotherapy","authors":"А.Н. Батян, В. Н. Волонцевич, Е. В. Гончарова, П. Д. Демешко, В.О. Лемешевский, Anatoly N. Batyan, Vitali N. Valantsevich, K. V. Hancharova, Pavel D. Dziameshka, Viktar O. Lemiasheuski","doi":"10.29235/1814-6023-2023-20-3-205-215","DOIUrl":"https://doi.org/10.29235/1814-6023-2023-20-3-205-215","url":null,"abstract":"Despite the fact that head and neck tumors are very sensitive to radiation treatment, patients who have completed a course of radiation therapy have a high rate of recurrence and mortality from the underlying disease.The aim of the study was to analyze the event-free survival of patients who completed a course of radiation therapy for stage I-III head and neck cancer according to a radical program under the influence of a number of independent factors such as age, gender, total focal dose, disease stage, duration of a break in a split course of radiation therapy.The effect of the duration of interruption on survival was assessed by analyzing the treatment regimens for patients who received radiation treatment for stage I-III head and neck cancer according to a radical program from 2016 to 2018 at the Brest Regional Oncological Dispensary. Statistical processing of the obtained data included the analysis by the Cox regression method. Data were analyzed using the Kaplan-Meier method to evaluate the outcome.In the multivariate analysis, it was found that the disease stage has the greatest relationship with event-free survival (p < 0.01). The same trend is observed for the duration of interruption in radiotherapy (p < 0.05). The cumulative survival was significantly higher in the group of patients with treatment interruption of less than 3 weeks compared to the group of patients who completed treatment more than 3 weeks apart (80.00 % vs 49.06 %). If the duration of the break is less than 3 weeks, the clinical stage (T1-T3) is not a factor influencing patient survival.Accounting for the effect of interruptions in the course of radiotherapy and the understanding the influence of controllable factors is essential for optimal treatment strategies.","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85212430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-28DOI: 10.29235/2524-2369-2023-68-3-193-202
A. V. Martyshchankava
The article discusses the results of sociological monitoring of public opinion on the use of nuclear energy in Belarus. The main part presents an analysis of the data obtained from the results of a sociological study conducted by the Institute of Sociology of the National Academy of Sciences of Belarus in 2022 on the assignment “Conduct sociological monitoring of public opinion of the population of the Republic of Belarus in order to form a positive attitude towards nuclear energy” of event 8 “Information and analytical support for the development of nuclear Energy in the Republic of Belarus” of subprogram 3 “Scientific support for the efficient and safe operation of the Belarusian nuclear power plant and promising areas for the development of nuclear energy” of the State Program “Science-intensive technologies and equipment” for 2021– 2025. The time intervals within which important events had a direct or indirect impact on public opinion about nuclear energy are characterized. A sociological method of calculation has been developed that makes it possible to trace the vector of public opinion’s response to nuclear energy (increase or decrease in the level of loyalty) to various internal or external factors. An assessment of the elasticity of public opinion about nuclear power is carried out with the construction of a typology of this elasticity. Also, self-assessments of the respondents’ formation and stability of their position regarding the implementation of the project “Belarusian NPP” were revealed. The need for systematic information and explanatory work among the population on all the main aspects of the practical use of nuclear energy is shown.
{"title":"Development of nuclear power in Belarus: a sociological analysis of the elasticity of public opinion","authors":"A. V. Martyshchankava","doi":"10.29235/2524-2369-2023-68-3-193-202","DOIUrl":"https://doi.org/10.29235/2524-2369-2023-68-3-193-202","url":null,"abstract":"The article discusses the results of sociological monitoring of public opinion on the use of nuclear energy in Belarus. The main part presents an analysis of the data obtained from the results of a sociological study conducted by the Institute of Sociology of the National Academy of Sciences of Belarus in 2022 on the assignment “Conduct sociological monitoring of public opinion of the population of the Republic of Belarus in order to form a positive attitude towards nuclear energy” of event 8 “Information and analytical support for the development of nuclear Energy in the Republic of Belarus” of subprogram 3 “Scientific support for the efficient and safe operation of the Belarusian nuclear power plant and promising areas for the development of nuclear energy” of the State Program “Science-intensive technologies and equipment” for 2021– 2025. The time intervals within which important events had a direct or indirect impact on public opinion about nuclear energy are characterized. A sociological method of calculation has been developed that makes it possible to trace the vector of public opinion’s response to nuclear energy (increase or decrease in the level of loyalty) to various internal or external factors. An assessment of the elasticity of public opinion about nuclear power is carried out with the construction of a typology of this elasticity. Also, self-assessments of the respondents’ formation and stability of their position regarding the implementation of the project “Belarusian NPP” were revealed. The need for systematic information and explanatory work among the population on all the main aspects of the practical use of nuclear energy is shown.","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82232068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-28DOI: 10.29235/2524-2369-2023-68-3-210-218
T. M. Aliferchyk
In the article the author considers some problems of modern Belarusian onomastic terminology related to the ordering of meanings and unification of onomastic terminology. It is proposed to clarify the definitions of individual terms in accordance with the current state of onomastics. Cases of unjustified congestion of the terminological system with highly specialized terms are analyzed.
{"title":"On the issue of ordering the Belarusian onomastic terminology","authors":"T. M. Aliferchyk","doi":"10.29235/2524-2369-2023-68-3-210-218","DOIUrl":"https://doi.org/10.29235/2524-2369-2023-68-3-210-218","url":null,"abstract":"In the article the author considers some problems of modern Belarusian onomastic terminology related to the ordering of meanings and unification of onomastic terminology. It is proposed to clarify the definitions of individual terms in accordance with the current state of onomastics. Cases of unjustified congestion of the terminological system with highly specialized terms are analyzed.","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"153 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72571191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-28DOI: 10.29235/2524-2369-2023-68-3-203-209
D. Mazarchuk
The author relies on the thesis that the main factor in the development of Western European diplomacy in the early Modern period was the emergence and formation of the resident diplomacy. The article proposes a periodization of the development of diplomacy, based on an understanding of the development of Western European diplomacy in the 15th –16th centuries in the context of the transformation of the medieval socio-political model.Under the conditions of permanent internal and external political pressure, the medieval hierarchical model of the socio-political structure did not fulfill the function of legitimizing the new regimes on the Apennine peninsula. The peace of Lodi in 1454 consolidated the heterarchical or polycentric model of the socio-political structure, which assumed mutual recognition of the subjects of interstate relations as a source of legitimacy.In the second half of the 15th century this model, based on a network of stable diplomatic relations, was adopted by most of the major Italian states. Italian wars of 1494–1559 influenced the spread of the new style of diplomacy with its resident envoys to the leading states of Western Europe.Despite the crisis of the second half of the 16th century the model of a resident diplomatic representation has become the basic one in the European diplomacy of Modern age.
{"title":"The main stages in the development of Western European diplomacy in the early Modern period","authors":"D. Mazarchuk","doi":"10.29235/2524-2369-2023-68-3-203-209","DOIUrl":"https://doi.org/10.29235/2524-2369-2023-68-3-203-209","url":null,"abstract":"The author relies on the thesis that the main factor in the development of Western European diplomacy in the early Modern period was the emergence and formation of the resident diplomacy. The article proposes a periodization of the development of diplomacy, based on an understanding of the development of Western European diplomacy in the 15th –16th centuries in the context of the transformation of the medieval socio-political model.Under the conditions of permanent internal and external political pressure, the medieval hierarchical model of the socio-political structure did not fulfill the function of legitimizing the new regimes on the Apennine peninsula. The peace of Lodi in 1454 consolidated the heterarchical or polycentric model of the socio-political structure, which assumed mutual recognition of the subjects of interstate relations as a source of legitimacy.In the second half of the 15th century this model, based on a network of stable diplomatic relations, was adopted by most of the major Italian states. Italian wars of 1494–1559 influenced the spread of the new style of diplomacy with its resident envoys to the leading states of Western Europe.Despite the crisis of the second half of the 16th century the model of a resident diplomatic representation has become the basic one in the European diplomacy of Modern age. ","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90798602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-28DOI: 10.29235/2524-2369-2023-68-3-229-247
E. Chesnokova
The article analyzes the stories “The Mermaid” by the Belarusian writer Ales’ Kazhadub and “The Siren” by the Italian writer Giuseppe Tomasi di Lampedusa for the purpose of revealing in them the character of the archetypal basis, distinctive genre-thematic and artistic-visual features. A comprehensive approach to the analysis of the literary works was provided by such methods as mythopoetic, hermeneutic, cultural-historical and comparative. The writers embodied the archetype of the Great Mother in the images of chthonic creatures (a siren and a mermaid). A consistent analysis of the images and plots of the stories made it possible to define a circle of universal images that made up the “archetypal core” of the given works (the Hero/the Child/the Warrior, the Shadow, the Leader/the Wise, the Lover (or one who is capable of love), the Journey, etc.), and also to clarify the features of their genres, to trace the influence of artistic methods on the character of the characters and certain development of the plot lines.
{"title":"Understanding of the stories “The Mermaid” by Ales’ Kazhadub and “The Siren” by Giuseppe Tomasi di Lampeduza from the position of the theory of archetypes","authors":"E. Chesnokova","doi":"10.29235/2524-2369-2023-68-3-229-247","DOIUrl":"https://doi.org/10.29235/2524-2369-2023-68-3-229-247","url":null,"abstract":"The article analyzes the stories “The Mermaid” by the Belarusian writer Ales’ Kazhadub and “The Siren” by the Italian writer Giuseppe Tomasi di Lampedusa for the purpose of revealing in them the character of the archetypal basis, distinctive genre-thematic and artistic-visual features. A comprehensive approach to the analysis of the literary works was provided by such methods as mythopoetic, hermeneutic, cultural-historical and comparative. The writers embodied the archetype of the Great Mother in the images of chthonic creatures (a siren and a mermaid). A consistent analysis of the images and plots of the stories made it possible to define a circle of universal images that made up the “archetypal core” of the given works (the Hero/the Child/the Warrior, the Shadow, the Leader/the Wise, the Lover (or one who is capable of love), the Journey, etc.), and also to clarify the features of their genres, to trace the influence of artistic methods on the character of the characters and certain development of the plot lines.","PeriodicalId":20584,"journal":{"name":"Proceedings of the National Academy of Sciences of Belarus, Medical series","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90640695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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