Pub Date : 2022-12-01DOI: 10.2478/prolas-2022-0097
Marika Juško, I. Ivanovs
Abstract Hiatal hernias are one of the most common types of hernia, which are found in 55–60% patients over 50 years, but only 9% are symptomatic. In most cases hiatal hernia manifests with the signs of gastroesophageal reflux disease (GERD) and is managed with lifestyle changes and proton pump inhibitors. In some cases, surgical therapy is indicated. Usually, surgical repair includes cruroplasty and fundoplication; however, the recurrence rate is up to 42%. Mesh reinforcement helps to decrease recurrence rate, but may lead to a development of visceral adhesions, erosions, mesh migration or infection. To avoid these complications, a new completely resorbable mesh PhasixTM is offered in the market. The aim of the study was to evaluate the quality of life (QoL), complications, and patient satisfaction after large hiatal hernia repair with PhasixTM mesh at 1-year follow-up. All the patients were satisfied with the surgery. The median GERD Health Related QoL index was 6.5 points, which is significantly less than before surgery — 29.5 points (p = 0.04). There were no mesh related complications and no clinical data of recurrence. Hiatal hernia repair with slowly resorbable biosynthetic mesh PhasixTM has acceptable results in terms of GERD Health Related QoL, complications and patient satisfaction at one-year follow-up.
{"title":"Quality of life after hiatal hernia repair with biosynthetic mesh PhasixTM","authors":"Marika Juško, I. Ivanovs","doi":"10.2478/prolas-2022-0097","DOIUrl":"https://doi.org/10.2478/prolas-2022-0097","url":null,"abstract":"Abstract Hiatal hernias are one of the most common types of hernia, which are found in 55–60% patients over 50 years, but only 9% are symptomatic. In most cases hiatal hernia manifests with the signs of gastroesophageal reflux disease (GERD) and is managed with lifestyle changes and proton pump inhibitors. In some cases, surgical therapy is indicated. Usually, surgical repair includes cruroplasty and fundoplication; however, the recurrence rate is up to 42%. Mesh reinforcement helps to decrease recurrence rate, but may lead to a development of visceral adhesions, erosions, mesh migration or infection. To avoid these complications, a new completely resorbable mesh PhasixTM is offered in the market. The aim of the study was to evaluate the quality of life (QoL), complications, and patient satisfaction after large hiatal hernia repair with PhasixTM mesh at 1-year follow-up. All the patients were satisfied with the surgery. The median GERD Health Related QoL index was 6.5 points, which is significantly less than before surgery — 29.5 points (p = 0.04). There were no mesh related complications and no clinical data of recurrence. Hiatal hernia repair with slowly resorbable biosynthetic mesh PhasixTM has acceptable results in terms of GERD Health Related QoL, complications and patient satisfaction at one-year follow-up.","PeriodicalId":20651,"journal":{"name":"Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80084995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.2478/prolas-2022-0089
Jekaterina Rodina, A. Derovs
Abstract Gastrointestinal mucosa forms a surface that interacts with many external factors. Beside the digestion and absorption of nutrients, it also acts as a barrier to allergens, pathogens, and toxins. Leaky gut syndrome is defined as a gut mucosal barrier dysfunction, which results in abnormally increased intestinal permeability. Research shows that leaky gut syndrome (LGS) has a pathogenetic relationship with a series of gastrointestinal and extra-intestinal disorders. This review discusses the current understanding of intestinal barrier composition and pathological contribution of LGS to various diseases. The major aim of this paper is to review different methods for diagnostics and evaluation of intestinal wall permeability, identifying their priorities and disadvantages.
{"title":"Establishing the cut-offs of leaky gut syndrome diagnostic: where are we now?","authors":"Jekaterina Rodina, A. Derovs","doi":"10.2478/prolas-2022-0089","DOIUrl":"https://doi.org/10.2478/prolas-2022-0089","url":null,"abstract":"Abstract Gastrointestinal mucosa forms a surface that interacts with many external factors. Beside the digestion and absorption of nutrients, it also acts as a barrier to allergens, pathogens, and toxins. Leaky gut syndrome is defined as a gut mucosal barrier dysfunction, which results in abnormally increased intestinal permeability. Research shows that leaky gut syndrome (LGS) has a pathogenetic relationship with a series of gastrointestinal and extra-intestinal disorders. This review discusses the current understanding of intestinal barrier composition and pathological contribution of LGS to various diseases. The major aim of this paper is to review different methods for diagnostics and evaluation of intestinal wall permeability, identifying their priorities and disadvantages.","PeriodicalId":20651,"journal":{"name":"Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90393476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.2478/prolas-2022-0099
Ilze Miklaseviča, N. Popova, S. Lapsa, A. Ozoliņš, M. Radzina
Abstract Although the risk of persistent biliary duct injury is low, cholecystectomy is one of the most commonly performed procedures worldwide. The occurrence of bile duct injury (BDI) results in complicated reconstructions, prolonged hospitalisation, repeated diagnostic examinations, and a high risk of long-term complications, leading to cost increase. A wide range of diagnostic methods are used to identify the damage and the associated complications. The aim of the study was to evaluate the impact of iatrogenic post-cholecystectomy BDI on the amount of diagnostic imaging and hospital re-admission rate. The retrospective cross-sectional study included the analysis of records of 38 patients undergoing laparoscopic cholecystectomy, referred to the Diagnostic Radiology Institute, Pauls Stradiņš Clinical University Hospital, who underwent diagnostic imaging. Among those who had iatrogenic BDI due to cholecystectomy, 57.9% (22 patients) underwent abdominal ultrasonography, 47.4% (18 patients) underwent endoscopic retrograde cholangiopancreatography, 47.4% (18 patients) underwent percutaneous transhepatic cholangiography (PTCA), 44.7% (17 patients) underwent computed tomography, 42.1% (16 patients) underwent magnetic resonance imaging, 13.2% (five patients) underwent US-guided puncture after cholecystectomy, and 15.8% (six patients) underwent fistulography. 18.4% (seven patients) were re-admitted to hospital once due to post-cholecystectomy complications, 34.2% (13 patients) twice, 15.8% (six patients) three times, 5.3% (two patients) four times, 13.2% (five patients) five times, 2.6% (one patient) seven times, 2.6% (one patient) ten times, 5.3% (two patients) eleven times and 2.6% (one patient) was re-admitted twenty-five times. Statistically significant strong correlation between hospital re-admission rate and PTCA (rs = 0.682, p < 0.001) was found. Iatrogenic post-cholecystectomy BDI significantly affects repeated diagnostic imaging and the hospital re-admission rate and, therefore, negatively affects hospital economics and patient welfare.
尽管持续胆管损伤的风险很低，但胆囊切除术是世界范围内最常用的手术之一。胆管损伤(BDI)的发生导致复杂的重建、长期住院、反复诊断检查和长期并发症的高风险，导致费用增加。广泛的诊断方法用于识别损伤和相关并发症。本研究的目的是评估医源性胆囊切除术后BDI对诊断影像量和再入院率的影响。这项回顾性横断面研究包括对38名接受腹腔镜胆囊切除术的患者的记录进行分析，这些患者被转到保罗斯Stradiņš临床大学医院诊断放射学研究所，接受了诊断成像。在胆囊切除术后发生医源性BDI的患者中，行腹部超声检查的占57.9%(22例)，行内镜逆行胆管造影的占47.4%(18例)，行经皮经肝胆管造影(PTCA)的占47.4%(18例)，行计算机断层扫描的占44.7%(17例)，行磁共振成像的占42.1%(16例)，行超声穿刺的占13.2%(5例)。15.8%(6例)行瘘管造影。因胆囊切除术后并发症再次住院1次的占18.4%(7例)，2次占34.2%(13例)，3次占15.8%(6例)，4次占5.3%(2例)，5次占13.2%(5例)，7次占2.6%(1例)，10次占2.6%(1例)，11次占5.3%(2例)，25次占2.6%(1例)。再入院率与PTCA有显著相关性(rs = 0.682, p < 0.001)。医源性胆囊切除术后BDI显著影响重复诊断成像和再入院率，因此对医院经济和患者福利产生负面影响。
{"title":"Impact of iatrogenic post-cholecystectomy biliary duct injury on quantity of diagnostic imaging and hospital re-admission","authors":"Ilze Miklaseviča, N. Popova, S. Lapsa, A. Ozoliņš, M. Radzina","doi":"10.2478/prolas-2022-0099","DOIUrl":"https://doi.org/10.2478/prolas-2022-0099","url":null,"abstract":"Abstract Although the risk of persistent biliary duct injury is low, cholecystectomy is one of the most commonly performed procedures worldwide. The occurrence of bile duct injury (BDI) results in complicated reconstructions, prolonged hospitalisation, repeated diagnostic examinations, and a high risk of long-term complications, leading to cost increase. A wide range of diagnostic methods are used to identify the damage and the associated complications. The aim of the study was to evaluate the impact of iatrogenic post-cholecystectomy BDI on the amount of diagnostic imaging and hospital re-admission rate. The retrospective cross-sectional study included the analysis of records of 38 patients undergoing laparoscopic cholecystectomy, referred to the Diagnostic Radiology Institute, Pauls Stradiņš Clinical University Hospital, who underwent diagnostic imaging. Among those who had iatrogenic BDI due to cholecystectomy, 57.9% (22 patients) underwent abdominal ultrasonography, 47.4% (18 patients) underwent endoscopic retrograde cholangiopancreatography, 47.4% (18 patients) underwent percutaneous transhepatic cholangiography (PTCA), 44.7% (17 patients) underwent computed tomography, 42.1% (16 patients) underwent magnetic resonance imaging, 13.2% (five patients) underwent US-guided puncture after cholecystectomy, and 15.8% (six patients) underwent fistulography. 18.4% (seven patients) were re-admitted to hospital once due to post-cholecystectomy complications, 34.2% (13 patients) twice, 15.8% (six patients) three times, 5.3% (two patients) four times, 13.2% (five patients) five times, 2.6% (one patient) seven times, 2.6% (one patient) ten times, 5.3% (two patients) eleven times and 2.6% (one patient) was re-admitted twenty-five times. Statistically significant strong correlation between hospital re-admission rate and PTCA (rs = 0.682, p < 0.001) was found. Iatrogenic post-cholecystectomy BDI significantly affects repeated diagnostic imaging and the hospital re-admission rate and, therefore, negatively affects hospital economics and patient welfare.","PeriodicalId":20651,"journal":{"name":"Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76737067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.2478/prolas-2022-0094
Irēna Teterina, V. Mokricka, E. Petrošina, J. Pokrotnieks
Abstract Inflammatory bowel diseases (IBD) are frequently accompanied by extraintestinal manifestations (EIMs) due to systemic autoimmune processes, which are important in the management of IBD patients and their long-term outcomes. The aim of the study was to determine the occurrence of EIMs comorbidities and their burden in IBD patients, based on the Latvian nationwide reimbursed prescription database from 2012 till 2019. Incident Crohn’s disease (CD) and ulcerative colitis (UC) patients between 2014 and 2018 were matched on age and sex with non-treated IBD controls and followed up until 2019. EIMs were selected based on a previously used methodology and grouped into organ systems. The cohort was tested for differences in the timing and occurrence of EIMs, as well as overall cumulating disease burden. The study population included 187 CD and 1137 UC patients. Higher prevalence of EIMs was observed in untreated IBD patients, whereas in the treated IBD patient group prevalence remained numerically similar. Among treated patients, the most common EIMs affected cardiovascular, hepatopancreatobiliary, endocrine, musculoskeletal, respiratory, and the skin and intestinal tract systems, where 28.4–79.9% of IBD patients experienced these EIMs for the first time before their IBD diagnosis. The treated female IBD patients tended to have higher frequency of EIMs compared to male patients. The overall comorbidity burden trend increased with time. The study provides evidence that treated IBD patients have lower risk for EIMs/comorbidities compared to untreated IBD patients.
{"title":"Burden of extraintestinal manifestations and comorbidities in treated and untreated ulcerative colitis and Crohn’s disease: a Latvian nationwide prescription database study 2014–2019","authors":"Irēna Teterina, V. Mokricka, E. Petrošina, J. Pokrotnieks","doi":"10.2478/prolas-2022-0094","DOIUrl":"https://doi.org/10.2478/prolas-2022-0094","url":null,"abstract":"Abstract Inflammatory bowel diseases (IBD) are frequently accompanied by extraintestinal manifestations (EIMs) due to systemic autoimmune processes, which are important in the management of IBD patients and their long-term outcomes. The aim of the study was to determine the occurrence of EIMs comorbidities and their burden in IBD patients, based on the Latvian nationwide reimbursed prescription database from 2012 till 2019. Incident Crohn’s disease (CD) and ulcerative colitis (UC) patients between 2014 and 2018 were matched on age and sex with non-treated IBD controls and followed up until 2019. EIMs were selected based on a previously used methodology and grouped into organ systems. The cohort was tested for differences in the timing and occurrence of EIMs, as well as overall cumulating disease burden. The study population included 187 CD and 1137 UC patients. Higher prevalence of EIMs was observed in untreated IBD patients, whereas in the treated IBD patient group prevalence remained numerically similar. Among treated patients, the most common EIMs affected cardiovascular, hepatopancreatobiliary, endocrine, musculoskeletal, respiratory, and the skin and intestinal tract systems, where 28.4–79.9% of IBD patients experienced these EIMs for the first time before their IBD diagnosis. The treated female IBD patients tended to have higher frequency of EIMs compared to male patients. The overall comorbidity burden trend increased with time. The study provides evidence that treated IBD patients have lower risk for EIMs/comorbidities compared to untreated IBD patients.","PeriodicalId":20651,"journal":{"name":"Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82496600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.2478/prolas-2022-0093
A. Lescinska, I. Ivanovs
Abstract Achalasia is a primary defect of esophageal motility of unknown aetiology, characterised by peristaltic dysfunction of the esophagus and impaired relaxation of the lower esophageal sphincter. The most common symptoms are dysphagia, regurgitation, weight loss, and chest burning. There are various treatment options for achalasia: botulinum toxin injections, pneumatic dilatation, Heller myotomy, and peroral endoscopic myotomy. The aim of the study was to access the efficacy and quality of life of patients with achalasia after surgical treatment — laparoscopic Heller myotomy and Dor fundoplication. All of the patients after surgery had a high gastrointestinal quality of life index. For all patients, during the follow-up period (median 2.4 years), the intensity of clinical symptoms after the procedure declined. Laparoscopic Heller myotomy with Dor fundoplication is a safe and effective method of treating achalasia and can reduce clinical symptoms and improve patients' quality of life.
{"title":"Surgical treatment of achalasia: results and quality of life","authors":"A. Lescinska, I. Ivanovs","doi":"10.2478/prolas-2022-0093","DOIUrl":"https://doi.org/10.2478/prolas-2022-0093","url":null,"abstract":"Abstract Achalasia is a primary defect of esophageal motility of unknown aetiology, characterised by peristaltic dysfunction of the esophagus and impaired relaxation of the lower esophageal sphincter. The most common symptoms are dysphagia, regurgitation, weight loss, and chest burning. There are various treatment options for achalasia: botulinum toxin injections, pneumatic dilatation, Heller myotomy, and peroral endoscopic myotomy. The aim of the study was to access the efficacy and quality of life of patients with achalasia after surgical treatment — laparoscopic Heller myotomy and Dor fundoplication. All of the patients after surgery had a high gastrointestinal quality of life index. For all patients, during the follow-up period (median 2.4 years), the intensity of clinical symptoms after the procedure declined. Laparoscopic Heller myotomy with Dor fundoplication is a safe and effective method of treating achalasia and can reduce clinical symptoms and improve patients' quality of life.","PeriodicalId":20651,"journal":{"name":"Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76364558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.2478/prolas-2022-0106
A. Derovs, J. Derova, J. Pokrotnieks
Abstract The X Anniversary Latvian Gastroenterology Congress with International Participation has been held for the first time for a two-day period (3–4 December, 2021). The first day was devoted to international and local satellite symposia, with a total number of ten, which corresponded to the number of Congresses held. The second day of the Congress was devoted to the plenary session. Due to the severe COVID-19 epidemiology situation in Latvia, for the first time in its history since 2003, it was decided to hold the Congress not in person but remotely from the Rīga Stradiņš University Great Hall stage, with live video broadcasting. Despite the fact that the Congress was virtual, the two days attracted a significant number of participants — 753 registered colleagues. The invited guests included foreign lecturers from the United States, Israel, Germany, Croatia, UK, Italy, and other countries and the discussion panel was led by field leaders from around the world. We continued our tradition of preparing published reports of the congress in a special issue of Proceedings of the Latvian Academy of Sciences, Section B, in collaboration with the Latvian Academy of Sciences.
{"title":"On the X Anniversary Latvian Gastroenterology Congress with International Participation","authors":"A. Derovs, J. Derova, J. Pokrotnieks","doi":"10.2478/prolas-2022-0106","DOIUrl":"https://doi.org/10.2478/prolas-2022-0106","url":null,"abstract":"Abstract The X Anniversary Latvian Gastroenterology Congress with International Participation has been held for the first time for a two-day period (3–4 December, 2021). The first day was devoted to international and local satellite symposia, with a total number of ten, which corresponded to the number of Congresses held. The second day of the Congress was devoted to the plenary session. Due to the severe COVID-19 epidemiology situation in Latvia, for the first time in its history since 2003, it was decided to hold the Congress not in person but remotely from the Rīga Stradiņš University Great Hall stage, with live video broadcasting. Despite the fact that the Congress was virtual, the two days attracted a significant number of participants — 753 registered colleagues. The invited guests included foreign lecturers from the United States, Israel, Germany, Croatia, UK, Italy, and other countries and the discussion panel was led by field leaders from around the world. We continued our tradition of preparing published reports of the congress in a special issue of Proceedings of the Latvian Academy of Sciences, Section B, in collaboration with the Latvian Academy of Sciences.","PeriodicalId":20651,"journal":{"name":"Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89678634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.2478/prolas-2022-0102
Madara Dzudzilo, I. Čēma, R. Kleina, Š. Svirskis, G. Selga
Abstract Dysregulation of the cell cycle is an important factor in a potentially malignant oral disorder. There have not been many studies on the role of the cell cycle regulator p27 in oral non-homogenous leukoplakia. The aim of our study was to characterise the p27 protein in homogenous and non-homogenous oral leukoplakias (OL), in comparison with healthy mucosa and squamous cell carcinoma tissues. The current study included 25 patients with OL, 15 cases with oral squamous cell carcinoma, and 15 samples of healthy oral mucosa, both as comparison groups. Immunohistochemical p27 antigen expression was determined by a standard EnView imaging system. The expression level of p27 in nodular and verrucous leukoplakia was lower than in homogenous OL but higher than in erythroleukoplakia. There was a statistically significant difference (p < 0.05) between the expression of p27 in healthy mucosa and homogenous OL. There was a significantly lower amount of p27 positive cells in oral cancer than in OL (p < 0.0001); however, its intracytoplasmic presence was diagnosed. Our study proved the instability of p27 protein and its dual nature in non-homogenous OL and OSCC, and therefore, it can be used as a predictive marker for the clinical course of these conditions.
{"title":"Characteristics of the dual nature of the p27 protein in oral leukoplakias and cancer","authors":"Madara Dzudzilo, I. Čēma, R. Kleina, Š. Svirskis, G. Selga","doi":"10.2478/prolas-2022-0102","DOIUrl":"https://doi.org/10.2478/prolas-2022-0102","url":null,"abstract":"Abstract Dysregulation of the cell cycle is an important factor in a potentially malignant oral disorder. There have not been many studies on the role of the cell cycle regulator p27 in oral non-homogenous leukoplakia. The aim of our study was to characterise the p27 protein in homogenous and non-homogenous oral leukoplakias (OL), in comparison with healthy mucosa and squamous cell carcinoma tissues. The current study included 25 patients with OL, 15 cases with oral squamous cell carcinoma, and 15 samples of healthy oral mucosa, both as comparison groups. Immunohistochemical p27 antigen expression was determined by a standard EnView imaging system. The expression level of p27 in nodular and verrucous leukoplakia was lower than in homogenous OL but higher than in erythroleukoplakia. There was a statistically significant difference (p < 0.05) between the expression of p27 in healthy mucosa and homogenous OL. There was a significantly lower amount of p27 positive cells in oral cancer than in OL (p < 0.0001); however, its intracytoplasmic presence was diagnosed. Our study proved the instability of p27 protein and its dual nature in non-homogenous OL and OSCC, and therefore, it can be used as a predictive marker for the clinical course of these conditions.","PeriodicalId":20651,"journal":{"name":"Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82789735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.2478/prolas-2022-0095
O. Knyazev, A. Kagramanova, A. Parfenov
Abstract We investigated the efficacy of combination therapy using bone marrow-derived mesenchymal stromal cells (MSC) and Infliximab (IFX) to achieve “deep remission” in patients with luminal Crohn disease (CD). Our study included 72 patients (age 19–62 years) (Ме = 29) with luminal CD. Patients in the 1st group (n = 21) received standard 5-aminosalicylic acid (5-ASA) and glucocorticosteroid therapy in combination with MSC. Patients in the 2nd group (n = 32) were prescribed anti-cytokine therapy IFX. Patients in the 3rd group (n = 19) received MSC and IFX. Clinical and immunobiological (C-reactive protein-CRP and faecal calprotectin-FCP) showed a more significant decrease of local and systemic inflammation activity in the 3rd group of patients. During a 5-year follow-up we observed longer duration of remission in patients who received MSC and IFX compared to the 1st (р = 0,04) and 2nd groups of patients (р = 0.038). Combination therapy of bone marrow-derived MSC and IFL provides “deep remission” in patients with luminal CD and has higher prognostic value for duration of CD remission period.
{"title":"Mesenchymal stem cell therapy in patients with Crohn’s disease — 5 year follow-up","authors":"O. Knyazev, A. Kagramanova, A. Parfenov","doi":"10.2478/prolas-2022-0095","DOIUrl":"https://doi.org/10.2478/prolas-2022-0095","url":null,"abstract":"Abstract We investigated the efficacy of combination therapy using bone marrow-derived mesenchymal stromal cells (MSC) and Infliximab (IFX) to achieve “deep remission” in patients with luminal Crohn disease (CD). Our study included 72 patients (age 19–62 years) (Ме = 29) with luminal CD. Patients in the 1st group (n = 21) received standard 5-aminosalicylic acid (5-ASA) and glucocorticosteroid therapy in combination with MSC. Patients in the 2nd group (n = 32) were prescribed anti-cytokine therapy IFX. Patients in the 3rd group (n = 19) received MSC and IFX. Clinical and immunobiological (C-reactive protein-CRP and faecal calprotectin-FCP) showed a more significant decrease of local and systemic inflammation activity in the 3rd group of patients. During a 5-year follow-up we observed longer duration of remission in patients who received MSC and IFX compared to the 1st (р = 0,04) and 2nd groups of patients (р = 0.038). Combination therapy of bone marrow-derived MSC and IFL provides “deep remission” in patients with luminal CD and has higher prognostic value for duration of CD remission period.","PeriodicalId":20651,"journal":{"name":"Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85065109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.2478/prolas-2022-0103
S. Laivacuma, I. Zeltiņa, A. Derovs, A. Norko, S. Isajevs, Karīna Makejeva, J. Drenth
Abstract Epithelioid haemangioendothelioma (EHE) is a rare vascular soft tissue malignant tumour with unknown etiology; the estimated prevalence of EHE is less than one in 1 million. A 56-year-old man was admitted in our department due to pain in the right side of the abdomen lasting for two years and weight loss up to 10 kg. Since 2012, the patient underwent lung and abdominal CT scanning as well as biopsy, however the diagnosis was challenging. In 2015, repeated abdominal CT scanning and a liver core biopsy was performed. The epithelioid haemangioendothelioma was diagnosed based by histopathological examination with subsequent radiological and clinical correlation. Therefore, accurate histopathological examination with radiological and clinical correlation is essential in the diagnosis of epithelioid haemangioendothelioma.
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Pub Date : 2022-12-01DOI: 10.2478/prolas-2022-0104
Marie Lindholm, Ivanda Franckeviča, A. Derovs, A. Dabužinskienė, R. Kleina
Abstract Delayed diagnosis of stomach, intestines, pancreas, and gallbladder diseases plays a significant role in the complicated non-traumatic peritonitis. The aim of the study was to analyse the causes of fatal peritonitis, and contributing factors to mortality and diagnostic discrepancies. A retrospective study of 52 peritonitis cases from selected 1350 autopsy records in three years was done. We analysed age, sex, length of hospital stays, clinical and pathological diagnosis, complications, comorbidities, laboratory values and diagnostic discrepancies. The results were statistically assessed by Excel and IBM SPSS® Statistics version 26. The most common causes of fatal peritonitis were non-oncological gastrointestinal pathologies (26%), malignancies (23%), pancreas and gallbladder (16%), HIV related (10%), vascular (7%) and other diseases (18%). Mean age of patients at death was 65 years. 61. 4% were males. Median hospitalisation time was two days. Six patients died outside the hospital. In 17.4% cases misdiagnoses were found. Common situations when misdiagnoses had occurred were intestinal ischaemia, malignancies of various origins and perforation of peptic ulcer. Fatal peritonitis was determined by the patient’s delayed hospitalisation with untreated oncological and non-oncological diseases of organs of the abdominal cavity and multiple concomitant diseases. Other contributing factors included not visiting general practitioners and lack of adherence to patients themselves.
摘要胃、肠、胰、胆囊疾病的延迟诊断在并发非外伤性腹膜炎中具有重要意义。该研究的目的是分析致死性腹膜炎的原因，以及导致死亡率和诊断差异的因素。回顾性分析了近三年来1350例尸检记录中52例腹膜炎的病例。我们分析了年龄、性别、住院时间、临床和病理诊断、并发症、合并症、实验室值和诊断差异。采用Excel和IBM SPSS®Statistics version 26对结果进行统计评估。致死性腹膜炎最常见的原因是非肿瘤性胃肠道疾病(26%)、恶性肿瘤(23%)、胰腺和胆囊(16%)、HIV相关(10%)、血管(7%)和其他疾病(18%)。患者平均死亡年龄为65岁。61. 4%为男性。中位住院时间为2天。6名病人在医院外死亡。误诊率为17.4%。常见的误诊情况是肠缺血、各种来源的恶性肿瘤和消化性溃疡穿孔。致死性腹膜炎是由患者因未经治疗的腹腔器官肿瘤和非肿瘤疾病以及多种伴随疾病而延迟住院决定的。其他影响因素包括不去看全科医生，以及患者自身缺乏依从性。
{"title":"Fatal peritonitis — causes, contributing factors and diagnostic challenges: an autopsy cases study","authors":"Marie Lindholm, Ivanda Franckeviča, A. Derovs, A. Dabužinskienė, R. Kleina","doi":"10.2478/prolas-2022-0104","DOIUrl":"https://doi.org/10.2478/prolas-2022-0104","url":null,"abstract":"Abstract Delayed diagnosis of stomach, intestines, pancreas, and gallbladder diseases plays a significant role in the complicated non-traumatic peritonitis. The aim of the study was to analyse the causes of fatal peritonitis, and contributing factors to mortality and diagnostic discrepancies. A retrospective study of 52 peritonitis cases from selected 1350 autopsy records in three years was done. We analysed age, sex, length of hospital stays, clinical and pathological diagnosis, complications, comorbidities, laboratory values and diagnostic discrepancies. The results were statistically assessed by Excel and IBM SPSS® Statistics version 26. The most common causes of fatal peritonitis were non-oncological gastrointestinal pathologies (26%), malignancies (23%), pancreas and gallbladder (16%), HIV related (10%), vascular (7%) and other diseases (18%). Mean age of patients at death was 65 years. 61. 4% were males. Median hospitalisation time was two days. Six patients died outside the hospital. In 17.4% cases misdiagnoses were found. Common situations when misdiagnoses had occurred were intestinal ischaemia, malignancies of various origins and perforation of peptic ulcer. Fatal peritonitis was determined by the patient’s delayed hospitalisation with untreated oncological and non-oncological diseases of organs of the abdominal cavity and multiple concomitant diseases. Other contributing factors included not visiting general practitioners and lack of adherence to patients themselves.","PeriodicalId":20651,"journal":{"name":"Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91096366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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