Pub Date : 2012-08-06DOI: 10.3724/SP.J.1206.2011.00618
Y. Zhong, Yannan Qin, Shisheng Sun, Wentian Chen, Zheng Li
{"title":"New Progress of Glycan as Receptors for Influenza Virus*: New Progress of Glycan as Receptors for Influenza Virus*","authors":"Y. Zhong, Yannan Qin, Shisheng Sun, Wentian Chen, Zheng Li","doi":"10.3724/SP.J.1206.2011.00618","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00618","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"26 1","pages":"605-612"},"PeriodicalIF":0.3,"publicationDate":"2012-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84224931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-08-06DOI: 10.3724/SP.J.1206.2012.00199
N. Deng, Yi Ao, Zhen-He Guan, Yue Su
{"title":"Prospect of Building The Strategic Alliances of Technical Innovation in China Biomedical Industry: Prospect of Building The Strategic Alliances of Technical Innovation in China Biomedical Industry","authors":"N. Deng, Yi Ao, Zhen-He Guan, Yue Su","doi":"10.3724/SP.J.1206.2012.00199","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00199","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"161 1","pages":"631-639"},"PeriodicalIF":0.3,"publicationDate":"2012-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77369408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-08-06DOI: 10.3724/SP.J.1206.2011.00536
Jian Huang, Yan-ping Zhao, Qian Li, Junxian Zhang, Y. Wang, Bei Zhang
{"title":"Association of Single Nucleotide Polymorphisms of NBS1 Gene With Genetic Susceptibility to Primary Liver Cancer in a Chinese Han Population*: Association of Single Nucleotide Polymorphisms of NBS1 Gene With Genetic Susceptibility to Primary Liver Cancer in a Chinese Han Population*","authors":"Jian Huang, Yan-ping Zhao, Qian Li, Junxian Zhang, Y. Wang, Bei Zhang","doi":"10.3724/SP.J.1206.2011.00536","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00536","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"52 1","pages":"678-686"},"PeriodicalIF":0.3,"publicationDate":"2012-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76899699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-08-01DOI: 10.3724/SP.J.1206.2012.00211
Zhu Li, 朱笠, Liu Jianghong, Wu Ying
Post-transcriptional regulation plays a central role in the development and maintenance of the nervous system.Defects in post-transcriptional regulation lead to neurodegenerative diseases.Mounting evidence suggests that the impaired post-transcriptional regulation of associated genes contribute to the neurodegenerative process,such as Alzheimer's disease(AD).This review discusses the role of disruption of alternative splicing regulation of the human tau gene(MAPT) and alterations of microRNA expression in the pathogenesis of neurodegeneration including AD.A brief overview is provided for the role and the mechanism of post-transcriptional regulation in AD pathogenesis.
{"title":"Impaired Post-transcriptional Regulation in Alzheimer′s Disease","authors":"Zhu Li, 朱笠, Liu Jianghong, Wu Ying","doi":"10.3724/SP.J.1206.2012.00211","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00211","url":null,"abstract":"Post-transcriptional regulation plays a central role in the development and maintenance of the nervous system.Defects in post-transcriptional regulation lead to neurodegenerative diseases.Mounting evidence suggests that the impaired post-transcriptional regulation of associated genes contribute to the neurodegenerative process,such as Alzheimer's disease(AD).This review discusses the role of disruption of alternative splicing regulation of the human tau gene(MAPT) and alterations of microRNA expression in the pathogenesis of neurodegeneration including AD.A brief overview is provided for the role and the mechanism of post-transcriptional regulation in AD pathogenesis.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"105 1","pages":"703-708"},"PeriodicalIF":0.3,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79411362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-07-30DOI: 10.3724/SP.J.1206.2012.00237
A. Li, H. Gong
{"title":"Progress on Whole Brain Imaging Methods at The Level of Optical Microscopy*: Progress on Whole Brain Imaging Methods at The Level of Optical Microscopy*","authors":"A. Li, H. Gong","doi":"10.3724/SP.J.1206.2012.00237","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00237","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"40 1","pages":"498-504"},"PeriodicalIF":0.3,"publicationDate":"2012-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78451731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-07-30DOI: 10.3724/SP.J.1206.2011.00484
Dawu Wang, Zhenming Hu, J. Hao, Bin He, Qiang Gan, Xiao-ming Zhong, Jieliang Shen, Ji Fang
{"title":"Sirtuin 1 Maitains Survival via PKB Signaling in Degenerative Human Disc Nucleus Pulposus Cells*: Sirtuin 1 Maitains Survival via PKB Signaling in Degenerative Human Disc Nucleus Pulposus Cells*","authors":"Dawu Wang, Zhenming Hu, J. Hao, Bin He, Qiang Gan, Xiao-ming Zhong, Jieliang Shen, Ji Fang","doi":"10.3724/SP.J.1206.2011.00484","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00484","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"86 1","pages":"563-573"},"PeriodicalIF":0.3,"publicationDate":"2012-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88515826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-07-30DOI: 10.3724/SP.J.1206.2012.00185
An Yunhe, Zhang Haofeng, S. Min, Z. Jun, Chen Xiuqin, Chen Dong, L. Di, F. Jing, Yang Dongling, S. Lina, Y. Xiyun, 阎锡蕴, J. Zhang
Sialyl-Tn(sTn) is a tumor-associated carbohydrate antigen overexpressed in many carcinomas.But whether it is expressed in neoplastic human endometrium is controversial.Here we screened 111 clinical samples including 82 endometrial cancers,16 atypical hyperplastic and 13 normal endometria,by immunohistochemistry using a novel anti-sTn antibody,namely 3P9.Our results showed that the expression of sTn in the endometrial carcinoma was significantly higher(76%) than that in normal tissues(31%)(P 0.01) and in atypical hyperplasia(44%)(P 0.05).Importantly,we found that sTn expression in typeⅠ carcinoma(80%) was obviously higher than that in typeⅡ(45%)(P 0.05).These results suggested that sTn may be a biomarker for endometrial carcinoma,especially for typeⅠcarcinoma.Moreover,we observed that sTn expression was increased with the decline of tumor histological grade(P 0.05),indicating that sTn was associated with a favorable prognosis in endometrial carcinoma.
{"title":"sTn is a Novel Biomarker for Type I Endometrial Carcinoma","authors":"An Yunhe, Zhang Haofeng, S. Min, Z. Jun, Chen Xiuqin, Chen Dong, L. Di, F. Jing, Yang Dongling, S. Lina, Y. Xiyun, 阎锡蕴, J. Zhang","doi":"10.3724/SP.J.1206.2012.00185","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00185","url":null,"abstract":"Sialyl-Tn(sTn) is a tumor-associated carbohydrate antigen overexpressed in many carcinomas.But whether it is expressed in neoplastic human endometrium is controversial.Here we screened 111 clinical samples including 82 endometrial cancers,16 atypical hyperplastic and 13 normal endometria,by immunohistochemistry using a novel anti-sTn antibody,namely 3P9.Our results showed that the expression of sTn in the endometrial carcinoma was significantly higher(76%) than that in normal tissues(31%)(P 0.01) and in atypical hyperplasia(44%)(P 0.05).Importantly,we found that sTn expression in typeⅠ carcinoma(80%) was obviously higher than that in typeⅡ(45%)(P 0.05).These results suggested that sTn may be a biomarker for endometrial carcinoma,especially for typeⅠcarcinoma.Moreover,we observed that sTn expression was increased with the decline of tumor histological grade(P 0.05),indicating that sTn was associated with a favorable prognosis in endometrial carcinoma.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"40 1","pages":"548-555"},"PeriodicalIF":0.3,"publicationDate":"2012-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87431486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-07-30DOI: 10.3724/SP.J.1206.2011.00311
Ming Zheng, Yanxin Huang, Wei-Lun Shen, Yi Zhong, Jianan Wu, Guixia Liu, You Zhou
{"title":"A Novel Scale-free Network Construction Method and Its Application in Gene Expression Profiles Simulation*: A Novel Scale-free Network Construction Method and Its Application in Gene Expression Profiles Simulation*","authors":"Ming Zheng, Yanxin Huang, Wei-Lun Shen, Yi Zhong, Jianan Wu, Guixia Liu, You Zhou","doi":"10.3724/SP.J.1206.2011.00311","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00311","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"14 1","pages":"581-590"},"PeriodicalIF":0.3,"publicationDate":"2012-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77725629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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