Przeglad dermatologiczny最新文献

Dermatological examination was done and patch tests were performed in 393 workers employed in contact with waste volatile ashes in electric power stations, and workers employed in construction material industry producing prefabricated construction blocks from these ashes. All studied workers were exposed also additionally to mineral oils. Eczema was found in 17.8% of cases, and oil acne in 8.1%. Chromium hypersensitivity was noted in 21.4% of workers, cobalt hypersensitivity in 12.2% and nickel hypersensitivity in 5.3%. Using the method of atomic absorption spectrophotometry the levels were assessed of chromium, cobalt and nickel in these ashes comparing them with the levels in cement. In the ashes the content of chromium and cobalt exceeded three times their content in cement. The content of soluble chromium compounds in the ashes was lower than in cement from European countries and approached that in American cement.

Using morphological and radionuclide methods the ability of engulfing and intracellular killing of Candida albicans cells by granulocytes of patients with atopic dermatitis was tested. The patients had moderately intense lesions without secondary infections. The results obtained by the morphological method, that is the percent of phagocytizing granulocytes, the percent of C. albicans cells engulfed by the granulocytes and the percent of killed C. albicans cells in the group of 25 patients and in the group of 25 controls were not statistically significantly different. The radionuclide method with 51Cr labelling of Candida albicans failed to demonstrate differences between 15 patients and 25 controls in the intracellular killing of these cells. No significant effect of the serum of healthy subjects on the functions of the granulocytes and no effect of the serum of the patients on granulocyte functions of controls were noted.

A retrospective analysis of survival time was carried out in 29 progressive systemic sclerosis patients treated with immunosuppressive drugs and in 15 patients who underwent another mode of treatment. It was found that fatality in both groups studied was the same (case fatality rate approximately 35%), but the mean survival time of those who had died was much longer for 10 patients treated with immunosuppressive drugs than for the 5 patients who had not undergone this mode of treatment (p less than 0.05). The cumulative survival rate evaluated at 5 years from the beginning of treatment was also higher in patients treated with immunosuppressive drugs (79.3%) than in the other group under investigation (66.7%). However the difference between these results was not statistically significant.

Results of studies "in vitro" of the susceptibility of 82 strains of Candida albicans for itraconazole and ketoconazole have been report. The strains were isolated from lesions of the mucous membranes and skin. The susceptibility of Candida albicans was tested to Minimal Inhibitory Concentration (MIC) and Total Inhibition Germination Tubes (TI100). The values of MICs and TI100 of itraconazole were 0.02-35.0 micrograms/ml and 0.02-18.0 micrograms/ml, respectively. The similar values of MICs and TI100 of ketoconazole were 0.04-80.0 micrograms/ml and 0.04-20.0 micrograms/ml. It has been showed that TI100 can be used as preliminary and rapid test of Candida albicans susceptibility for these drugs.

In 85 patients with alopecia areata the frequency of thyroid disease was assessed on the basis of history data, clinical examination and determination of T3, T4, TSH and presence of antithyroid antibodies of different specificity (ATMA, ATg, AMD). Among these patients abnormalities of thyroid structure and function were significantly more frequent (78%) than in the control group (33%). In 11% of the patients autoimmune thyroid disease was present (Graves-Basdow disease, Hashimoto thyroiditis). In 86 controls no cases of autoimmune diseases were found. In some patients only a slight enlargement of the thyroid was present (grade OB, I.).

Transferrin subtypes are considered to be some of genetic markers which can correlate with the incidence of certain diseases. The present study was designed to find out whether such a correlation is true for atopic dermatitis. Transferrin C subtypes (Tf CI, Tf C2, Tf C3) in blood serum were determined by the method of isoelectric focussing in polyacrylamide gel. Examinations were made in 30 atopic dermatitis patients. The control group was made up by a Polish population sample of 728 normal persons of both sexes. The results obtained were analysed statistically by means of test chi 2. There was no correlation between Tf C and atopic dermatitis (chi 2 = 0,638, d.f. = 2, 0,750 greater than p greater than 0,500).

The activity of granulocyte pyruvate kinase and glucose-6-phospho dehydrogenase in 12 patients with severe atopic dermatitis in active stage of disease and in remission was investigated. It was found that in active stage the activity of both enzymes was not significantly different than in healthy individuals. In remission pyruvate kinase activity was significantly decreased and glucose-6-phospho dehydrogenase activity was found to be non significantly decreased.

A case of disseminated cylindroma of the scalp is reported. Big tuberous lesions were removed surgically, and small nodules were treated twice with liquid nitrogen using a UK-32 device for cryotherapy.

A rare case of sebocystomatosis is reported. The lesions were present in a man aged 21 years since birth, involving the trunk; upper extremities, neck and clavicular areas where they had a streak-like form. The disease was present in his family since two generations. Cutaneous changes were associated with spinal abnormalities and Schmorl's nodules.

Dermato-venereological outpatient clinics are health service units for patients who want to be tested for HIV-antibodies and persons who are infected and are in need of medical care. The provincial clinics are also engaged in the training of health service workers and in health education in their own districts.