Przeglad dermatologiczny最新文献

A clinical, bacteriological and serological pictures of 45 patients with chancriform pyoderma are presented, A single ulcer (92.8%), localized on genitals (91.1%) in adult males (93.3%), imitating or very similar to syphilitic primary chancre in our material was observed. A second case in the literature, of chancriform pyoderma on the dorsal surface of the tongue was recorded.

The percentages of suppressor T lymphocytes were compared in 111 patients with atopic dermatitis and 100 healthy volunteers. In the former group there was a statistically significant reduction of suppressor T cells, which was not related to IgE level. Similar decrease in T cells has been found in patients with normal IgE as well as in patients having 10-fold increase in serum IgE. Our results were compared to previously published data of other investigators.

Cathepsin D activity and type I and III collagens content in the skin of rats treated with some antiinflammatory drugs (acetylsalicylic acid, phenylbutazone, indomethacin, colchicine and prednisone) were evaluated. It was found that investigated drugs evoke increased activity of cathepsin D and decreased collagen content (mainly type I) in this tissue. The correlation between type I collagen content and proteolytic activity was noticed.

A 63-year old patient who had suffered from mild lymphomatoid papulosis with periods of relapse and spontaneous remissions is presented. After 23 years of that chronic dermatosis he developed a malignant lymphoma covering skin, lymph nodes and internal organs, which was confirmed by histopathological examination. Despite intensive chemo and X-ray therapy the patient died. The importance of continuous follow-up of usually benign lymphomatoid papulosis is stressed.

The investigations were carried out in 20 patients with severe forms of psoriasis, and in 18 healthy subjects. The generation of free superoxide radicals by polymorphonuclear leukocytes of peripheral blood was evaluated by Bellavite et al. (1983) method by use superoxide dismutase of Sigma firm. The obtained results may confirm alterations in PMNL functions in patients with psoriasis observed by many authors. It may confirm the probability of damage of membrane structures and alterations in their bactericidal functions.

In a female patient aged 68 years an extensive basal cell carcinoma with a proliferating tumour in its central part was observed. In view of the age of the patient, the extent and location of the lesion, and refusal to undergo surgical treatment combined treatment was used, with radiotherapy (5900 R, 70-45 KV, 10 mA) and compresses of 5-fluorouracil. The tumour became flat and epithelialization developed.

The results of the treatment in two groups of patients with neurosyphilis are compared. In 23 cases, i.v. infusions of crystalline penicillin were given for 10 days in daily dose of 20-24 mega U., combined with probenecid. Then it was followed by i.m. procaine penicillin in daily dose of 1.2 mega U., in total dose 12-50 mega U. The mean duration of follow-up was 7,8 months. The second group (34 cases) was treated with procaine penicillin i.m. in daily dose of 1.2 mega U., the total dose was 24-60 mega U. The mean duration of follow-up was 2.5 years. The differences between the results of the treatment in both groups were not significant. In 3 reinfected patients with early asymptomatic neurosyphilis in spite of intensive treatment with penicillin sero- and cerebro-spinal fluid-resistant syphilis developed.

The purpose of the study was evaluation of the clinical usefulness of determination of antibodies to soluble nuclear antigens. The study was carried out in 71 cases of various collagen diseases. Antibodies dsDNA (IIF method with Crithidium luciliae as substrate) were found only in patients with SLE and renal involvement. RNP antibodies (double immunodiffusion method) were demonstrated in 83.3% of cases of mixed connective tissue disease, and Sm antibodies in 8% of SLE patients. It is worth stressing that in the presented material Sm antibodies were present only in association with RNP antibodies. Antibodies Ro and/or La were present most often in the sera of patients with SCLE, while Scl 70 antibodies were a marker of systemic sclerosis, more frequent in patients with diffuse scleroderma, while their demonstration in acroscleroderma suggested a more severe course of the disease. The study showed a high diagnostic and prognostic value of antibodies to soluble nuclear antigens in collagen diseases.

The metabolism of the arachidonic acid (AA) in normal skin is presented, and the role of its metabolites (eicosanoids) in pathogenesis of psoriasis is reviewed. Beside, possibility of the treatment of psoriasis by means of fish oil and eicosapentaenoic acid (EPA) is discussed.