Przeglad dermatologiczny最新文献

A 20-year-old female patient is reported with urticaria pigmentosa and coexisting nodules (mastocytoma) resembling clinically lesions of the type of xanthoma tuberosum. An analysis of microscopic image and ultrastructural changes was carried out and modern views on treatment of cutaneous mastocytosis are discussed.

In the years 1974-1988 in the Department of Otorhinolaryngology Medical Academy in Cracow 60 patients were treated surgically for malignant tumours of the auricle. Their mean age was 61.9 years, males prevailed (82%). In 1 case the malignant lesion involved also the external auditory meatus and in 4 cases it spread to the skin near the auricle. Histological examinations demonstrated basal cell carcinoma in 22 cases (37%), spinocellular carcinoma in 31 cases (52%), basal-spinocellular carcinoma in 6 cases (10%) and malignant melanoma in 1 case. In 3 cases of spinocellular carcinoma metastases to lymph nodes were found. In 30 cases partial amputation of the auricle was done, in one of them recurrence developed after over 5 years. Advanced malignant lesions in 30 cases required extensive operation with removal of the lesion within margins of healthy tissue, removal of lymph nodes with metastases and one-step plastic operation. Recurrences developed in 2 cases. Hyperkeratotic foci near the malignant tumour were present in 64% of these patients. They made difficult preoperative qualification and required more extensive excision of the neoplasm. After tumour removal from the external meatus the resulting tissue defect must be filled with a skin graft since healing by granulation tissue development leads to obliteration of the meatus. Two out of 7 patients required additional interventions for maintenance of the patency of the meatus.

In the clinic of dermatological surgery, I Department of Dermatology Silesian Medical Academy in Katowice 328 patients were treated surgically for granuloma teleangiectodes in the years 1973-1988. Two methods were used: excision of the lesion and curettage with electrocoagulation of the base of the lesion. After excision the wound was closed by approximation of its margins or local plastic procedure (285 cases) and by covering it with a free full-thickness skin graft (3 cases). Curettage and electrocoagulation was used in 43 cases, mainly due to the location of the lesion (in 90% on fingers). After granuloma excision no recurrences were observed, while after curettage and electrocoagulation recurrences developed in 20% of cases.

From 1973 to 1988 in the Dermatological Surgery Unit of the 1st Department of Dermatology of the Silesian School of Medicine in Katowice 82 patients were treated surgically for keratoacanthoma. In 76 patients the defect was closed by simple bringing closer the edges or by local plastic surgery, in 6 patients it was covered with free full-thickness skin grafts. The preparations of the excised tumors from various places were examined histologically. In three cases the texture of carcinoma spinocellulare was found in the base of the tumor. In 98% of the patients the wounds healed by first intention.

In a clinical study on 74 patients with 102 crural ulcers levamisole 150 mg was given for 1 or 2 successive days daily during 3 to 17 weeks, besides conventional treatment. The method seems to raise the per cent of favourable therapeutic results in such cases. Drug tolerance was good and no dangerous complications were observed in any case.

In the group of 150 men with urological diseases simultaneous examinations of urethra swabs and sperm specimens were done. By culture method on McCoy cells Chlamydia trachomatis was found more frequently in semen (46.7%) than in urethra (35.3%); in 103 patients with urethritis the results were 43.6% and 33.0% respectively. Consistently positive results were obtained in 33 (26.0%) and consistently negative ones in 66 (44.05) of all examined men. In 31 (20.7%) patients, 22 with urethritis including Chlamydia trachomatis was cultured from semen alone and in 14 (9.3%) from urethra alone. The above findings suggest that human semen constitutes a valuable diagnostic material in cases suspected of infection due to Chlamydia trachomatis.

The activity of ketoconazole and itraconazole against 102 strains of Candida sp. was compared in the investigation "in vitro". The investigational material was taken from patients with different types of mycosis. The values of MICs of ketoconazole and itraconazole were 0.04-100.0 micrograms/ml and 0.02-35.0 micrograms/ml, respectively. From the data obtained it is evident that the average efficacy of itraconazole is 3 to 10 times higher in comparison with ketoconazole though 8 strains (7, 8 percent) of investigated strains have shown greater sensitivity to ketoconazole.