Przeglad dermatologiczny最新文献

NDGA is known as an inhibitor of leukotrienes and may exert some effect on psoriatic lesion formation. The aim of the study was to test the influence of this drug on appearance of psoriatic plaques. 7 day application of 0.015% NDGA on psoriatic lesions under occlusion in 23 patients, gave some flattening of lesions as compared to controls. However, after finishing of application all the changes reappeared in previous form. We have never observed permanent beneficial effect in any patient.

The NK activity of peripheral blood mononuclear cells (PBMC) was evaluated in 90 patients with various subsets of systemic scleroderma (SSc). The NK activity, as performed with K-562 as target cell, was found to be significantly lowered in patients with diffuse scleroderma, but did not differ from the healthy control in patients with acrosclerosis. The lowest values in the NK activity assay were obtained in patients with most extensive skin involvement and severe internal organ changes. The NK activity of healthy donors' PBMC was significantly decreased by addition of SSc patients PBMC (50:1) to the cytotoxicity assay, but was not influenced by the patients sera.

In a group of 100 consecutive patients with eczema all those hypersensitive to nickel had also hypersensitivity to palladium. Allergy to the latter element was never found in patients with negative tests for nickel. The clinical importance of this combined allergy is discussed.

In the skin of healthy subjects linear deposits were found of fibronectin at the dermoepidermal junction and in the walls of blood vessels, and reticular deposits in the papillary and reticular layers of the skin. In the epidermis of 12 out of 51 patients with allergic contact dermatitis fibronectin deposits were found in relation to Langerhans cells and keratinocytes. This was not observed in the epidermis in healthy subjects. The authors suggest that fibronectin on the surface of Langerhans cells and keratinocytes may play a role in antigen presentation.

In patients with allergic changes hospitalized in the years 1984-1988 in the Department a careful history was obtained for detection of correlations between the appearance of skin lesions and contact with plants. In patients with a positive history patch tests were done with a panel of routine allergens and leaves and/or flowers of certain plants. Positive tests with various plants were obtained in 14 cases. In 6 patients reporting contact with primrose positive tests were obtained with flowers and leaves of this plant, four of five tobacco planters tested who had eczematous lesions of the hands, aave also positive results of the test with tobacco leaves, and in three children reporting contact with butter-cup changes were observed resembling dermatitis pratensis bullosa. In one case allergy to parsnip was demonstrated. It is stressed that plants may give rise to contact dermatitis as well as to allergic-toxic changes.

A literature survey is presented concerning the clinical pattern of early syphilis in subjects infected with HIV. The course of syphilis infection in HIV-positive subjects differs often from the usual one, the clinical picture may be that of the so called malignant syphilis with early development of syphilitic lesions in the central nervous system and involvement of the visual system; Serological reactions differ also, they may give negative results or may appear with delay, sometimes high titres of these reactions are found.

102 Chlamydia trachomatis isolates obtained from pregnant women and 42 isolates from man-consorts of women with chlamydial infection of cervix were immunotyped using a microimmunofluorescence (micro IF) with monoclonal antibodies kit (Washington Research Foundation, Seattle, USA). In both groups of patients the most common serovars were: E (37.3%) and D (24.6%) belonging to B-complex. Additional serovars noted were: F (11.3%), J (11.3%), I' (4.5%), I (3.5%, K (3.5%), G (2.8%) and H. Ba (both 0.2%). N. gonorrhoeae and/or T. vaginalis infections were more frequent from patients with B-complex Ch. trachomatis serovars (28/75 that is 37%) than C-complex Ch. trachomatis serovars (3/25 that is 12%).

The aim of the present study was to determine the levels of lysozyme in serum and saliva in 10 patients with atopic dermatitis (AD). A significantly decreased lysozyme levels in saliva compared to controls (p less than 0.01) were showed, whereas no differences were found in lysozyme activity in serum of patients and controls. The reduced levels in saliva can hardly be explained. The decreased levels of lysozyme in external fluids may be one explanation for the well-known predisposition for AD patients to an increased susceptibility to many cutaneous infections.

A review of recently described cases with oral chronic erosive or ulcerative lesions associated with stratified epithelium specific antinuclear antibodies (SES-ANA) is presented. The lesions are refractory to local and systemic corticosteroids but may be responsive to hydroxychloroquine.

The studies were performed in 48 patients with morphea and included evaluation of 1) antinuclear antibodies 2) lymphocyte induced angiogenesis 3) natural killer (NK) cell activity and 4) T cell subpopulations in peripheral blood. The presence of antinuclear antibodies was found in 44.4% (8/18) patients with scleroderma linearis and in 21% (4/19) patients with morphea disseminata. Lymphocyte induced angiogenesis was increased in 41.5% (17/41) morphea patients, mainly in cases with pronounced vascular changes. The E rosette forming test showed a decreased percentage of active rosette forming cells (ARFC) and total rosette forming cells (TRFC) in peripheral blood and the NK cell activity was lowered in patients with morphea. These results obtained in patients with morphea show some similarities and differences in comparison to cellular immunity disturbances in patients with systemic scleroderma.