Przeglad dermatologiczny最新文献

In the years 1978-1988 a group of 2257 subjects was examined for the presence of fungal infection. In 785 cases positive results of cultures were obtained yielding 468 dermatophytes (60.1%) and 317 yeast-like fungi (39.9%). The most frequently isolated fungi were: Candida albicans (27.3%), Trichophyton mentagrophytes v. interdigitale (27.0%) and Trichophyton rubrum (20.6%). In the subgroup of dermatophytes anthropophilic fungi accounted for 87.5%.

In the years 1984-1988 in the Department of Dermatology, M. A. in Gdańsk 80 cases of microsporum mycoses were diagnosed. The cases were due to Microsporum canis. Among 80 cases of this mycosis we found 59 children aged from 2 to 15 years and 21 subjects aged over 15 years. In children the most cases were diagnosed in the age group 4-7 years. In 40 cases (50%). M. canis produced lesions of hairless skin and in 36 cases (45%) the scalp was involved.

The Chlamydiazyme Test was used in the laboratory examination of 1139 patients (716 women, 368 men, 55 children) hospitalized in the departments of urology, nephrology and gynaecology. Urethral and cervical smears were examined. In comparison with the culture method for C. trachomatis on McCoy cells the Chlamydiazyme test had a 91.6% agreement of the positive and negative results. The disagreeing results, that is only Chlamydiazyme test positive or only culture positive, accounted respectively for 2.1% and 6.2% of the results. The sensitivity of the Chlamydiazyme test was 74.6% and its specificity was 97.2%.

A case of eosinophilic pustular folliculitis is described. The patient was a man aged 28 years with typical clinical and histological findings. The disease developed after an insect sting. Evident improvement was obtained after administration of sulphones with corticosteroids.

The frequency of positive results of patch tests with nickel was analysed in 1044 patients with positive results of patch tests examined because of suspected occupational diseases in the years 1977-1988. More frequent presence of allergy to nickel was demonstrated in women (21.8%) than men (6.9%), and it was found that the allergy to this metal has increased sixfold in women in the period 1985-1988 in relation to the period 1977-1980. A particularly high increase of the allergy to nickel in women was observed in the last year (69.4%). This increase of allergy was noted not only in young women but also in middle-aged ones. In women monovalent allergy to nickel and bivalent allergy to nickel and cobalt prevailed, while in men bivalent allergy to nickel and chromium was most frequent. The problems of diagnosis and expertise in occupational diseases in women with allergy to nickel present in metal jewelry and working in contact with metals in occupation are discussed.

Akne-Mycyna, a new preparation for external treatment of acne containing 1% erythromycin, was used in 30 cases of acne: 12 cases of papulo-pustolous acne, 13 with pustulous acne, 5 with acne conglobata. The age of the patients ranged from 16 to 27 years, the mean duration of acne was 3.5 years. Selected lesions were smeared with Akne-Mycyna twice daily, mostly on one side of the face; symmetrical lesions were treated by conventional external methods. In the light of the study it is concluded that Akne-Mycyna is a very effective preparation for external treatment of papulo-pustulous acne and in milder cases of pustulous acne, with the duration of treatment at least 3 weeks. In deep forms of acne, particularly acne conglobata, Akne-Mycyna may be a valuable supplementation of systemic treatment.

Ten patients with psoriasis were treated for three days with salicylic acid ointment with vaseline vehicle. In all patients the serum concentration of salicylic acid increased systematically and the concentration depended on the amount of ointment used and on psoriasis form. Only in one case of exudative psoriasis the level of salicylic acid reached the value causing intoxication, and produced a diffuse inflammatory erythema with itching. The treatment caused no changes of biochemical indices.

In the trichological studies on the model of Wistar rats aged 4-5 weeks intraperitoneal vinblastine in doses of 0.008-0.030 mg/100 g of body weight caused initially mixed (dystrophic-telogenic) hair loss. After higher doses and longer drug administration the mechanism of hair loss was transformed to dystrophic. In both forms of hair loss signs of advanced diffuse alopecia were found.

In the last 25 years 268 (67%) patients were hospitalized for proper tuberculosis of the skin, and 132 (33%) for tuberculids. In the period 1983-1987 the prevalence of skin tuberculosis was 5.8 times lower than in the period 1963-1967. The frequency of the clinical forms of tuberculosis was as follows: tbc. luposa (57.5%), tbc. colliquativa (35.4%), tbc. verrucosa (4.5%) and tbc. ulcerosa (2.6%). Women had tbc. luposa 1.4 times, and tbc. colliquativa 1.5 times more frequently than men, while in men tbc. verrucosa was 3 times and tbc. ulcerosa 2.5 times more frequently than in women. In the whole group the male:female ratio was 1:2.05. In patients aged up to 20 years tbc colliquativa was more frequent (29.5%) than tbc. luposa (5.2%), while in the age group 61-85 years this frequency was reversed: 17.9% and 34.4% respectively. In the division into occupational groups farmers prevailed (3.6%) (t = 2.84). The number of female patients with tbc. luposa significantly less frequently (t = 4.0) got married, probably due to disfiguring changes following the disease.

Metronidazole cream 1% was applied externally for the treatment of rosacea during 2 months in 14 women and 6 men. Two patients failed to come for control examination. Out of 18 patients who completed the treatment in 5 the lesions disappeared completely and were not returning during 3 months of follow-up, in 11 cases an improvement was achieved, in 1 case no improvement occurred, and in 1 case worsening was noted. These results suggest that the cream with metronidazole is an effective treatment for rosacea.